1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	leukocytes	leukocyte	NNS	NNS	_	1	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	binding	binding	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	thrombin-stimulated	thrombin-stimulated	JJ	JJ	_	11	amod	_	_
11	platelets	platelet	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Activated	activate	VBN	VBN	_	4	amod	_	_
4	platelets	platelet	NNS	NNS	_	5	nsubj	_	_
5	tether	tether	VBP	VBP	_	1	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activate	activate	VBP	VBP	_	5	conj	_	_
8	myeloid	myeloid	JJ	JJ	_	9	amod	_	_
9	leukocytes	leukocyte	NNS	NNS	_	5	dobj	_	_
10	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	potential	potential	JJ	JJ	_	5	amod	_	_
5	relevance	relevance	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	acute	acute	JJ	JJ	_	12	amod	_	_
11	myocardial	myocardial	JJ	JJ	_	12	amod	_	_
12	infarction	infarction	NN	NN	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	AMI	ami	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	2	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	examined	examine	VBD	VBD	_	2	parataxis	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	18	dobj	_	_
21	by	by	IN	IN	_	23	case	_	_
22	leukocyte-platelet	leukocyte-platelet	JJ	JJ	_	23	amod	_	_
23	adhesion	adhesion	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	occurrence	occurrence	NN	NN	_	20	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	leukocyte-platelet	leukocyte-platelet	JJ	JJ	_	29	amod	_	_
29	conjugates	conjugate	NNS	NNS	_	26	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	patients	patient	NNS	NNS	_	18	nmod	_	_
32	with	with	IN	IN	_	33	case	_	_
33	AMI	ami	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	RESULTS	result	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	We	we	PRP	PRP	_	1	dep	_	_
6	obtained	obtain	VBD	VBD	_	1	acl	_	_
7	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
8	venous	venous	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	samples	sample	NNS	NNS	_	6	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	20	20	CD	CD	_	13	nummod	_	_
13	patients	patient	NNS	NNS	_	6	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	AMI	ami	NN	NN	_	13	nmod	_	_
16	before	before	IN	IN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	daily	daily	RB	RB	_	21	advmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	5	5	CD	CD	_	21	nummod	_	_
21	days	day	NNS	NNS	_	16	conj	_	_
22	after	after	IN	IN	_	27	case	_	_
23	direct	direct	JJ	JJ	_	27	amod	_	_
24	percutaneous	percutaneous	JJ	JJ	_	27	amod	_	_
25	transluminal	transluminal	JJ	JJ	_	27	amod	_	_
26	coronary	coronary	JJ	JJ	_	27	amod	_	_
27	angioplasty	angioplasty	NN	NN	_	21	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	PTCA	ptca	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	13	cc	_	_
32	in	in	IN	IN	_	34	case	_	_
33	20	20	CD	CD	_	34	nummod	_	_
34	patients	patient	NNS	NNS	_	13	conj	_	_
35	undergoing	undergo	VBG	VBG	_	34	acl	_	_
36	elective	elective	JJ	JJ	_	37	amod	_	_
37	PTCA	ptca	NN	NN	_	35	dobj	_	_
38	.	.	.	.	_	1	punct	_	_

1	Throughout	throughout	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	study	study	NN	NN	_	4	compound	_	_
4	period	period	NN	NN	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	CD41	cd41	NN	NN	_	7	compound	_	_
7	immunofluorescence	immunofluorescence	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	flow	flow	NN	NN	_	12	compound	_	_
12	cytometry	cytometry	NN	NN	_	7	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	revealed	reveal	VBD	VBD	_	0	root	_	_
15	increased	increase	VBN	VBN	_	17	amod	_	_
16	leukocyte-platelet	leukocyte-platelet	JJ	JJ	_	17	amod	_	_
17	adhesion	adhesion	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	AMI	ami	NN	NN	_	19	nmod	_	_
22	compared	compare	VBN	VBN	_	25	case	_	_
23	with	with	IN	IN	_	25	case	_	_
24	control	control	JJ	JJ	_	25	amod	_	_
25	patients	patient	NNS	NNS	_	17	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	mean	mean	NN	NN	_	25	dep	_	_
28	+/-	+/-	CC	CC	_	27	cc	_	_
29	SE	se	NN	NN	_	27	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	fluorescence	fluorescence	NN	NN	_	27	nmod	_	_
32	-LSB-	-lsb-	-LRB-	-LRB-	_	33	punct	_	_
33	channels	channel	NNS	NNS	_	27	appos	_	_
34	-RSB-	-rsb-	-RRB-	-RRB-	_	33	punct	_	_
35	before	before	IN	IN	_	36	case	_	_
36	PTCA	ptca	NN	NN	_	27	nmod	_	_
37	:	:	:	:	_	27	punct	_	_
38	77	77	CD	CD	_	27	dep	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	16	16	CD	CD	_	38	conj	_	_
41	versus	versus	CC	CC	_	38	cc	_	_
42	35	35	CD	CD	_	38	conj	_	_
43	+/-	+/-	CC	CC	_	42	cc	_	_
44	9	9	CD	CD	_	42	conj	_	_
45	;	;	:	:	_	27	punct	_	_
46	P	p	NN	NN	_	27	dep	_	_
47	=	=	JJ	JJ	_	46	amod	_	_
48	.003	.003	CD	CD	_	47	dep	_	_
49	)	)	-RRB-	-RRB-	_	27	punct	_	_
50	.	.	.	.	_	14	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	7	advmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	thrombin-stimulated	thrombin-stimulated	JJ	JJ	_	6	amod	_	_
5	fixed	fixed	JJ	JJ	_	6	amod	_	_
6	platelets	platelet	NNS	NNS	_	7	nsubj	_	_
7	bound	bind	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	case	_	_
9	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	monocytes	monocyte	NNS	NNS	_	9	conj	_	_
12	.	.	.	.	_	7	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	2	2	CD	CD	_	3	nummod	_	_
3	hours	hour	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	this	this	DT	DT	_	6	nsubj	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	mRNA	mrna	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	17	case	_	_
11	interleukin	interleukin	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	IL	il	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	,	,	,	,	_	17	punct	_	_
16	1	1	CD	CD	_	17	nummod	_	_
17	beta	beta	NN	NN	_	9	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	IL-8	il-8	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	monocyte	monocyte	NN	NN	_	26	compound	_	_
23	chemoattractant	chemoattractant	NN	NN	_	26	compound	_	_
24	protein	protein	NN	NN	_	26	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	MCP	mcp	NN	NN	_	17	conj	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	-1	-1	CD	CD	_	26	nummod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	unfractionated	unfractionated	JJ	JJ	_	31	amod	_	_
31	leukocytes	leukocyte	NNS	NNS	_	9	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	4	4	CD	CD	_	3	nummod	_	_
3	hours	hour	NNS	NNS	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	IL-1	il-1	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	15	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-8	il-8	NN	NN	_	6	conj	_	_
9	concentration	concentration	NN	NN	_	6	dep	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cell-free	cell-free	JJ	JJ	_	13	amod	_	_
13	supernatant	supernatant	NN	NN	_	6	nmod	_	_
14	had	have	VBD	VBD	_	15	aux	_	_
15	increased	increase	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	20	case	_	_
17	268	268	CD	CD	_	20	nummod	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	36	36	CD	CD	_	17	conj	_	_
20	%	%	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	210	210	CD	CD	_	25	nummod	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	7	7	CD	CD	_	22	conj	_	_
25	%	%	NN	NN	_	20	conj	_	_
26	,	,	,	,	_	15	punct	_	_
27	respectively	respectively	RB	RB	_	15	advmod	_	_
28	,	,	,	,	_	15	punct	_	_
29	and	and	CC	CC	_	15	cc	_	_
30	cellular	cellular	JJ	JJ	_	32	amod	_	_
31	MCP-1	mcp-1	NN	NN	_	32	compound	_	_
32	content	content	NN	NN	_	34	nsubj	_	_
33	had	have	VBD	VBD	_	34	aux	_	_
34	increased	increase	VBN	VBN	_	15	conj	_	_
35	by	by	IN	IN	_	39	case	_	_
36	170	170	CD	CD	_	39	nummod	_	_
37	+/-	+/-	CC	CC	_	36	cc	_	_
38	8	8	CD	CD	_	36	conj	_	_
39	%	%	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	15	punct	_	_

1	Addition	addition	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	activated	activate	VBN	VBN	_	4	amod	_	_
4	platelets	platelet	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	adherent	adherent	JJ	JJ	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	similar	similar	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	8	conj	_	_
15	with	with	IN	IN	_	19	case	_	_
16	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
17	factor-kappa	factor-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	binding	binding	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	7	case	_	_
5	anti-P	anti-p	JJ	JJ	_	7	amod	_	_
6	selectin	selectin	NN	NN	_	7	compound	_	_
7	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
8	reduced	reduce	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effect	effect	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	activated	activate	VBN	VBN	_	13	amod	_	_
13	platelets	platelet	NNS	NNS	_	10	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	11	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	AMI	ami	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	leukocyte-platelet	leukocyte-platelet	JJ	JJ	_	9	amod	_	_
9	adhesion	adhesion	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	increased	increase	VBN	VBN	_	1	dep	_	_
12	.	.	.	.	_	1	punct	_	_

1	Binding	binding	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	activated	activate	VBN	VBN	_	4	amod	_	_
4	platelets	platelet	NNS	NNS	_	1	nmod	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	IL-1	il-1	NN	NN	_	7	compound	_	_
7	beta	beta	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	IL-8	il-8	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	MCP-1	mcp-1	NN	NN	_	7	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	leukocyte-platelet	leukocyte-platelet	JJ	JJ	_	6	amod	_	_
6	adhesion	adhesion	NN	NN	_	7	nsubj	_	_
7	contributes	contribute	VBZ	VBZ	_	3	ccomp	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	inflammatory	inflammatory	JJ	JJ	_	13	amod	_	_
13	responses	response	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	AMI	ami	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Defective	defective	JJ	JJ	_	2	amod	_	_
2	survival	survival	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activation	activation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	thymocytes	thymocyte	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	transgenic	transgenic	JJ	JJ	_	9	amod	_	_
9	mice	mouse	NNS	NNS	_	2	nmod	_	_
10	expressing	express	VBG	VBG	_	9	acl	_	_
11	a	a	DT	DT	_	14	det	_	_
12	catalytically	catalytically	RB	RB	_	14	advmod	_	_
13	inactive	inactive	JJ	JJ	_	14	amod	_	_
14	form	form	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	Ca2+/calmodulin-dependent	ca2+/calmodulin-dependent	JJ	JJ	_	18	amod	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	kinase	kinase	NN	NN	_	14	nmod	_	_
19	IV	iv	CD	CD	_	18	nummod	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	generated	generate	VBN	VBN	_	0	root	_	_
4	transgenic	transgenic	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	3	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	express	express	VBP	VBP	_	5	acl:relcl	_	_
8	a	a	DT	DT	_	11	det	_	_
9	catalytically	catalytically	RB	RB	_	11	advmod	_	_
10	inactive	inactive	JJ	JJ	_	11	amod	_	_
11	form	form	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	Ca2+/calmodulin-dependent	ca2+/calmodulin-dependent	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	kinase	kinase	NN	NN	_	11	nmod	_	_
16	IV	iv	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	CaMKIV	camkiv	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	specifically	specifically	RB	RB	_	24	advmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	thymic	thymic	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	7	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	results	result	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	markedly	markedly	RB	RB	_	10	advmod	_	_
10	reduced	reduce	VBN	VBN	_	12	amod	_	_
11	thymic	thymic	JJ	JJ	_	12	amod	_	_
12	cellularity	cellularity	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	although	although	IN	IN	_	22	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	distribution	distribution	NN	NN	_	22	nsubj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	remaining	remain	VBG	VBG	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	normal	normal	JJ	JJ	_	6	advcl	_	_
23	based	base	VBN	VBN	_	25	case	_	_
24	on	on	IN	IN	_	25	case	_	_
25	evaluation	evaluation	NN	NN	_	22	advcl	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	dep	_	_
28	CD4	cd4	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	CD8	cd8	NN	NN	_	28	conj	_	_
31	cell	cell	NN	NN	_	33	compound	_	_
32	surface	surface	NN	NN	_	33	compound	_	_
33	antigens	antigen	NNS	NNS	_	28	dep	_	_
34	that	that	WDT	WDT	_	36	nsubjpass	_	_
35	are	be	VBP	VBP	_	36	auxpass	_	_
36	used	use	VBN	VBN	_	28	acl:relcl	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	gauge	gauge	VB	VB	_	36	xcomp	_	_
39	T	t	NN	NN	_	41	compound	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	development	development	NN	NN	_	38	dobj	_	_
42	.	.	.	.	_	6	punct	_	_

1	Isolated	isolate	VBN	VBN	_	4	amod	_	_
2	thymic	thymic	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	10	nsubj	_	_
5	from	from	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transgenic	transgenic	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	4	nmod	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	15	det	_	_
12	dramatically	dramatically	RB	RB	_	13	advmod	_	_
13	decreased	decrease	VBN	VBN	_	15	amod	_	_
14	survival	survival	NN	NN	_	15	compound	_	_
15	rate	rate	NN	NN	_	10	dobj	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	evaluated	evaluate	VBN	VBN	_	10	advcl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	culture	culture	NN	NN	_	17	nmod	_	_
20	under	under	IN	IN	_	21	case	_	_
21	conditions	condition	NNS	NNS	_	19	nmod	_	_
22	that	that	WDT	WDT	_	25	nsubj	_	_
23	do	do	VBP	VBP	_	25	aux	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	favor	favor	VB	VB	_	21	acl:relcl	_	_
26	activation	activation	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	challenged	challenge	VBN	VBN	_	23	advcl	_	_
3	with	with	IN	IN	_	6	case	_	_
4	an	a	DT	DT	_	6	det	_	_
5	activating	activate	VBG	VBG	_	6	amod	_	_
6	stimulus	stimulus	NN	NN	_	2	nmod	_	_
7	such	such	JJ	JJ	_	9	case	_	_
8	as	as	IN	IN	_	7	mwe	_	_
9	alpha-CD3	alpha-cd3	NN	NN	_	6	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	combination	combination	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	phorbol	phorbol	NN	NN	_	15	compound	_	_
15	ester	ester	NN	NN	_	12	nmod	_	_
16	plus	plus	CC	CC	_	15	cc	_	_
17	ionophore	ionophore	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	23	punct	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cells	cell	NNS	NNS	_	23	nsubjpass	_	_
21	are	be	VBP	VBP	_	23	auxpass	_	_
22	severely	severely	RB	RB	_	23	advmod	_	_
23	compromised	compromise	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	26	case	_	_
25	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
26	ability	ability	NN	NN	_	23	nmod	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	produce	produce	VB	VB	_	26	acl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	cytokine	cytokine	NN	NN	_	28	dobj	_	_
31	interleukin-2	interleukin-2	NN	NN	_	30	dep	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	IL-2	il-2	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	23	punct	_	_

1	Reduction	reduction	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-2	il-2	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	secondary	secondary	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	inability	inability	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	phosphorylate	phosphorylate	VB	VB	_	9	acl	_	_
12	the	the	DT	DT	_	17	det	_	_
13	cAMP	camp	NN	NN	_	17	compound	_	_
14	response	response	NN	NN	_	17	compound	_	_
15	element	element	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	11	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	CREB	creb	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	11	punct	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	induce	induce	VBP	VBP	_	11	conj	_	_
23	expression	expression	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	immediate	immediate	JJ	JJ	_	28	amod	_	_
27	early	early	JJ	JJ	_	28	amod	_	_
28	genes	gene	NNS	NNS	_	23	nmod	_	_
29	such	such	JJ	JJ	_	32	case	_	_
30	as	as	IN	IN	_	29	mwe	_	_
31	Fos	fos	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	28	nmod	_	_
33	that	that	WDT	WDT	_	35	nsubjpass	_	_
34	are	be	VBP	VBP	_	35	auxpass	_	_
35	required	require	VBN	VBN	_	28	acl:relcl	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	transactivate	transactivate	VB	VB	_	35	xcomp	_	_
38	the	the	DT	DT	_	40	det	_	_
39	IL-2	il-2	NN	NN	_	40	compound	_	_
40	promoter	promoter	NN	NN	_	37	dobj	_	_
41	.	.	.	.	_	6	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	transgene	transgene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	regulated	regulate	VBN	VBN	_	33	advcl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	proximal	proximal	JJ	JJ	_	9	amod	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	murine	murine	JJ	JJ	_	14	amod	_	_
13	lck	lck	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	this	this	DT	DT	_	17	det	_	_
17	promoter	promoter	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	inactivated	inactivate	VBN	VBN	_	5	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	exit	exit	VBP	VBP	_	22	acl:relcl	_	_
25	the	the	DT	DT	_	26	det	_	_
26	thymus	thymus	NN	NN	_	24	dobj	_	_
27	,	,	,	,	_	33	punct	_	_
28	the	the	DT	DT	_	30	det	_	_
29	mutant	mutant	JJ	JJ	_	30	amod	_	_
30	hCaMKIV	hcamkiv	NN	NN	_	33	nsubj	_	_
31	is	be	VBZ	VBZ	_	33	cop	_	_
32	not	not	RB	RB	_	33	neg	_	_
33	present	present	JJ	JJ	_	0	root	_	_
34	in	in	IN	IN	_	37	case	_	_
35	peripheral	peripheral	JJ	JJ	_	37	amod	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	33	punct	_	_

1	Consequently	consequently	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	11	nsubjpass	_	_
5	present	present	JJ	JJ	_	4	amod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	spleen	spleen	NN	NN	_	5	nmod	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	activated	activate	VBN	VBN	_	0	root	_	_
12	normally	normally	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	either	either	DT	DT	_	17	det	_	_
17	stimulus	stimulus	NN	NN	_	14	nmod	_	_
18	mentioned	mention	VBN	VBN	_	17	acl	_	_
19	above	above	RB	RB	_	18	advmod	_	_
20	,	,	,	,	_	11	punct	_	_
21	demonstrating	demonstrate	VBG	VBG	_	11	advcl	_	_
22	that	that	IN	IN	_	32	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	effects	effect	NNS	NNS	_	32	nsubj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	inactive	inactive	JJ	JJ	_	28	amod	_	_
28	CaMKIV	camkiv	NN	NN	_	24	nmod	_	_
29	on	on	IN	IN	_	30	case	_	_
30	activation	activation	NN	NN	_	24	nmod	_	_
31	are	be	VBP	VBP	_	32	cop	_	_
32	reversible	reversible	JJ	JJ	_	21	ccomp	_	_
33	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CaMKIV	camkiv	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	represent	represent	VB	VB	_	3	ccomp	_	_
8	a	a	DT	DT	_	12	det	_	_
9	physiologically	physiologically	RB	RB	_	10	advmod	_	_
10	relevant	relevant	JJ	JJ	_	12	amod	_	_
11	CREB	creb	NN	NN	_	12	compound	_	_
12	kinase	kinase	NN	NN	_	7	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	the	the	DT	DT	_	19	det	_	_
19	enzyme	enzyme	NN	NN	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	required	require	VBN	VBN	_	7	conj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	ensure	ensure	VB	VB	_	22	xcomp	_	_
25	normal	normal	JJ	JJ	_	26	amod	_	_
26	expansion	expansion	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	thymus	thymus	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Whereas	whereas	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	pathway	pathway	NN	NN	_	9	nsubj	_	_
4	responsible	responsible	JJ	JJ	_	3	amod	_	_
5	for	for	IN	IN	_	8	case	_	_
6	this	this	DT	DT	_	8	det	_	_
7	latter	latter	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	17	advcl	_	_
10	yet	yet	RB	RB	_	9	advmod	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	elucidated	elucidate	VBN	VBN	_	9	xcomp	_	_
14	,	,	,	,	_	17	punct	_	_
15	it	it	PRP	PRP	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	unlikely	unlikely	JJ	JJ	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	include	include	VB	VB	_	17	xcomp	_	_
20	CREB	creb	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	class	class	NN	NN	_	5	compound	_	_
3	II	ii	CD	CD	_	5	nummod	_	_
4	trans-activator	trans-activator	NN	NN	_	5	compound	_	_
5	CIITA	ciita	NN	NN	_	6	nsubj	_	_
6	interacts	interact	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	TBP-associated	tbp-associated	JJ	JJ	_	11	amod	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	TAFII32	tafii32	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	trans-activator	trans-activator	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CIITA	ciita	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	the	the	DT	DT	_	12	det	_	_
10	main	main	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	co-activator	co-activator	NN	NN	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	MHC	mhc	NN	NN	_	20	compound	_	_
18	class	class	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	proteins	protein	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Its	its	PRP$	PRP$	_	5	nmod:poss	_	_
2	N-terminal	n-terminal	JJ	JJ	_	5	amod	_	_
3	125	125	CD	CD	_	5	nummod	_	_
4	amino	amino	NN	NN	_	5	compound	_	_
5	acids	acid	NNS	NNS	_	6	nsubj	_	_
6	function	function	VBP	VBP	_	0	root	_	_
7	as	as	IN	IN	_	12	case	_	_
8	an	a	DT	DT	_	12	det	_	_
9	independent	independent	JJ	JJ	_	12	amod	_	_
10	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
11	activation	activation	NN	NN	_	12	compound	_	_
12	domain	domain	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Analyses	analysis	NNS	NNS	_	12	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	primary	primary	JJ	JJ	_	7	amod	_	_
5	amino	amino	NN	NN	_	7	compound	_	_
6	acid	acid	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	activation	activation	NN	NN	_	11	compound	_	_
11	domain	domain	NN	NN	_	7	nmod	_	_
12	predict	predict	VBP	VBP	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	three	three	CD	CD	_	17	nummod	_	_
17	alpha-helices	alpha-helix	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	each	each	DT	DT	_	12	xcomp	_	_
20	with	with	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	high	high	JJ	JJ	_	23	amod	_	_
23	proportion	proportion	NN	NN	_	19	dep	_	_
24	of	of	IN	IN	_	26	case	_	_
25	acidic	acidic	JJ	JJ	_	26	amod	_	_
26	residues	residue	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	site-directed	site-directed	JJ	JJ	_	3	amod	_	_
3	mutagenesis	mutagenesis	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	1	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	found	find	VBD	VBD	_	1	parataxis	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	two	two	CD	CD	_	14	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	these	these	DT	DT	_	12	det	_	_
11	predicted	predict	VBN	VBN	_	12	amod	_	_
12	alpha-helices	alpha-helix	NNS	NNS	_	8	nmod	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	required	require	VBN	VBN	_	6	ccomp	_	_
15	for	for	IN	IN	_	18	case	_	_
16	full	full	JJ	JJ	_	18	amod	_	_
17	transcriptional	transcriptional	JJ	JJ	_	16	dep	_	_
18	activation	activation	NN	NN	_	14	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	CIITA	ciita	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Moreover	moreover	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	CIITA	ciita	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	14	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	13	nmod	_	_
8	both	both	DT	DT	_	10	det	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	alpha-helices	alpha-helix	NNS	NNS	_	13	nsubjpass	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	deleted	delete	VBN	VBN	_	5	acl:relcl	_	_
14	displays	display	VBZ	VBZ	_	0	root	_	_
15	a	a	DT	DT	_	18	det	_	_
16	dominant	dominant	JJ	JJ	_	18	amod	_	_
17	negative	negative	JJ	JJ	_	18	amod	_	_
18	phenotype	phenotype	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	activation	activation	NN	NN	_	3	compound	_	_
3	domain	domain	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CIITA	ciita	NN	NN	_	3	nmod	_	_
6	interacts	interact	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	32	32	CD	CD	_	11	nummod	_	_
10	kDa	kda	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	general	general	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	11	nmod	_	_
17	TFIID	tfiid	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	11	punct	_	_
19	TAFII32	tafii32	NN	NN	_	11	appos	_	_
20	.	.	.	.	_	6	punct	_	_

1	Decreased	decrease	VBN	VBN	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	10	nsubjpass	_	_
4	by	by	IN	IN	_	6	case	_	_
5	N-terminal	n-terminal	JJ	JJ	_	6	amod	_	_
6	deletions	deletion	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CIITA	ciita	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	correlated	correlate	VBN	VBN	_	0	root	_	_
11	directly	directly	RB	RB	_	10	advmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
14	reduced	reduce	VBN	VBN	_	15	amod	_	_
15	binding	binding	NN	NN	_	10	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	TAFII32	tafii32	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	interactions	interaction	NNS	NNS	_	10	nsubj	_	_
5	between	between	IN	IN	_	6	case	_	_
6	TAFII32	tafii32	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CIITA	ciita	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	responsible	responsible	JJ	JJ	_	2	ccomp	_	_
11	for	for	IN	IN	_	12	case	_	_
12	activation	activation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	class	class	NN	NN	_	16	compound	_	_
15	II	ii	CD	CD	_	16	nummod	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Specific	specific	JJ	JJ	_	3	amod	_	_
2	complex	complex	NN	NN	_	3	compound	_	_
3	formation	formation	NN	NN	_	0	root	_	_
4	between	between	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	type	type	NN	NN	_	11	compound	_	_
7	II	ii	CD	CD	_	11	nummod	_	_
8	bare	bare	JJ	JJ	_	11	amod	_	_
9	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
10	syndrome-associated	syndrome-associated	JJ	JJ	_	11	amod	_	_
11	transactivators	transactivator	NNS	NNS	_	3	nmod	_	_
12	CIITA	ciita	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	RFX5	rfx5	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	25	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	defective	defective	JJ	JJ	_	1	amod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	five	five	CD	CD	_	10	nummod	_	_
9	complementation	complementation	NN	NN	_	10	compound	_	_
10	groups	group	NNS	NNS	_	5	nmod	_	_
11	identified	identify	VBN	VBN	_	1	acl	_	_
12	in	in	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	class	class	NN	NN	_	18	compound	_	_
15	II-negative	ii-negative	JJ	JJ	_	18	amod	_	_
16	bare	bare	JJ	JJ	_	18	amod	_	_
17	lymphocyte	lymphocyte	NN	NN	_	18	compound	_	_
18	syndrome	syndrome	NN	NN	_	11	nmod	_	_
19	or	or	CC	CC	_	1	cc	_	_
20	corresponding	corresponding	JJ	JJ	_	22	amod	_	_
21	laboratory	laboratory	JJ	JJ	_	22	amod	_	_
22	mutants	mutant	NNS	NNS	_	1	conj	_	_
23	have	have	VBP	VBP	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	cloned	clone	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	encodes	encode	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	protein	protein	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	RFX5	rfx5	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	that	that	WDT	WDT	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	member	member	NN	NN	_	5	acl:relcl	_	_
13	of	of	IN	IN	_	20	case	_	_
14	the	the	DT	DT	_	20	det	_	_
15	RFX	rfx	NN	NN	_	20	compound	_	_
16	family	family	NN	NN	_	20	compound	_	_
17	of	of	IN	IN	_	20	amod	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	12	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	other	other	JJ	JJ	_	6	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	CIITA	ciita	NN	NN	_	2	appos	_	_
5	,	,	,	,	_	2	punct	_	_
6	encodes	encode	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	large	large	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	6	dobj	_	_
10	with	with	IN	IN	_	16	case	_	_
11	a	a	DT	DT	_	16	det	_	_
12	defined	define	VBN	VBN	_	16	amod	_	_
13	acidic	acidic	JJ	JJ	_	16	amod	_	_
14	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	9	nmod	_	_
17	;	;	:	:	_	6	punct	_	_
18	this	this	DT	DT	_	19	det	_	_
19	protein	protein	NN	NN	_	22	nsubj	_	_
20	does	do	VBZ	VBZ	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	interact	interact	VB	VB	_	6	parataxis	_	_
23	with	with	IN	IN	_	24	case	_	_
24	DNA	dna	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	plasmids	plasmid	NNS	NNS	_	14	nsubj	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	regions	region	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	RFX5	rfx5	NN	NN	_	4	nmod	_	_
7	fused	fuse	VBN	VBN	_	4	acl	_	_
8	to	to	TO	TO	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	GAL4	gal4	NN	NN	_	13	compound	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	7	nmod	_	_
14	activated	activate	VBD	VBD	_	0	root	_	_
15	transcription	transcription	NN	NN	_	14	dobj	_	_
16	from	from	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	reporter	reporter	NN	NN	_	19	compound	_	_
19	construct	construct	NN	NN	_	14	nmod	_	_
20	containing	contain	VBG	VBG	_	19	acl	_	_
21	GAL4	gal4	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	20	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	cotransfection	cotransfection	NN	NN	_	26	compound	_	_
26	assay	assay	NN	NN	_	14	nmod	_	_
27	in	in	IN	IN	_	33	case	_	_
28	the	the	DT	DT	_	33	det	_	_
29	Raji	raji	NN	NN	_	33	compound	_	_
30	human	human	JJ	JJ	_	33	amod	_	_
31	B	b	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	line	line	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	plasmids	plasmid	NNS	NNS	_	5	nsubj	_	_
5	produced	produce	VBD	VBD	_	0	root	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	HeLa	hela	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	only	only	RB	RB	_	13	advmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	conjunction	conjunction	NN	NN	_	5	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	interferon	interferon	NN	NN	_	16	compound	_	_
16	gamma	gamma	NN	NN	_	17	compound	_	_
17	stimulation	stimulation	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	a	a	DT	DT	_	20	det	_	_
20	condition	condition	NN	NN	_	13	appos	_	_
21	in	in	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	36	nmod	_	_
23	expression	expression	NN	NN	_	36	nsubjpass	_	_
24	of	of	IN	IN	_	26	case	_	_
25	both	both	CC	CC	_	26	cc:preconj	_	_
26	CIITA	ciita	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	class	class	NN	NN	_	34	compound	_	_
29	II	ii	CD	CD	_	34	nummod	_	_
30	major	major	JJ	JJ	_	34	amod	_	_
31	histocompatibility	histocompatibility	NN	NN	_	34	compound	_	_
32	complex	complex	NN	NN	_	34	compound	_	_
33	surface	surface	NN	NN	_	34	compound	_	_
34	proteins	protein	NNS	NNS	_	26	conj	_	_
35	are	be	VBP	VBP	_	36	auxpass	_	_
36	induced.	induced.	VBN	VBN	_	20	acl:relcl	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	plasmids	plasmid	NNS	NNS	_	7	nsubj	_	_
5	were	be	VBD	VBD	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	active	active	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	RJ2.2.5	rj2.2.5	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	an	a	DT	DT	_	15	det	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	14	advmod	_	_
14	mutagenized	mutagenize	VBN	VBN	_	15	amod	_	_
15	derivative	derivative	NN	NN	_	9	appos	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Raji	raji	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	25	nmod	_	_
20	both	both	DT	DT	_	21	det	_	_
21	copies	copy	NNS	NNS	_	25	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	CIITA	ciita	NN	NN	_	21	nmod	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	defective	defective	JJ	JJ	_	15	acl:relcl	_	_
26	.	.	.	.	_	7	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	10	nsubjpass	_	_
3	by	by	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	RFX5	rfx5	NN	NN	_	7	compound	_	_
6	fusion	fusion	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	restored	restore	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	RJ2.2.5	rj2.2.5	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	cotransfection	cotransfection	NN	NN	_	10	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	CIITA	ciita	NN	NN	_	19	compound	_	_
18	expression	expression	NN	NN	_	19	compound	_	_
19	plasmid	plasmid	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Finally	finally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	11	nsubjpass	_	_
6	between	between	IN	IN	_	7	case	_	_
7	RFX5	rfx5	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	CIITA	ciita	NN	NN	_	7	conj	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	yeast	yeast	NN	NN	_	11	nmod	_	_
15	two-hybrid	two-hybrid	JJ	JJ	_	14	amod	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	far-Western	far-western	JJ	JJ	_	18	amod	_	_
18	blot	blot	NN	NN	_	14	conj	_	_
19	assays	assay	NNS	NNS	_	14	dep	_	_
20	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	RFX5	rfx5	NN	NN	_	5	nsubj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	activate	activate	VB	VB	_	0	root	_	_
6	transcription	transcription	NN	NN	_	5	dobj	_	_
7	only	only	RB	RB	_	9	advmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cooperation	cooperation	NN	NN	_	5	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	CIITA	ciita	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	RFX5	rfx5	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	CIITA	ciita	NN	NN	_	1	conj	_	_
4	associate	associate	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	form	form	VB	VB	_	4	xcomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	complex	complex	NN	NN	_	6	dobj	_	_
9	capable	capable	JJ	JJ	_	8	amod	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	activating	activate	VBG	VBG	_	9	advcl	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	from	from	IN	IN	_	19	case	_	_
14	class	class	NN	NN	_	19	compound	_	_
15	II	ii	CD	CD	_	19	nummod	_	_
16	major	major	JJ	JJ	_	19	amod	_	_
17	histocompatibility	histocompatibility	NN	NN	_	19	compound	_	_
18	complex	complex	NN	NN	_	19	compound	_	_
19	promoters	promoter	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	complex	complex	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	specificity	specificity	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	determined	determine	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	RFX5	rfx5	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	the	the	DT	DT	_	20	det	_	_
18	general	general	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	apparatus	apparatus	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	recruited	recruit	VBN	VBN	_	8	conj	_	_
23	by	by	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	acidic	acidic	JJ	JJ	_	27	amod	_	_
26	activation	activation	NN	NN	_	27	compound	_	_
27	domain	domain	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	CIITA	ciita	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	CCAAT/enhancer	ccaat/enhancer	NN	NN	_	4	compound	_	_
2	binding	binding	NN	NN	_	4	compound	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	epsilon	epsilon	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	preferentially	preferentially	RB	RB	_	7	advmod	_	_
7	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
8	during	during	IN	IN	_	10	case	_	_
9	granulocytic	granulocytic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	versatility	versatility	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	determined	determine	VBN	VBN	_	7	conj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	alternative	alternative	JJ	JJ	_	19	amod	_	_
19	use	use	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	promoters	promoter	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	differential	differential	JJ	JJ	_	24	amod	_	_
24	splicing	splicing	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	CCAAT/enhancer	ccaat/enhancer	NN	NN	_	7	compound	_	_
2	binding	binding	NN	NN	_	7	compound	_	_
3	protein	protein	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	epsilon	epsilon	NN	NN	_	12	nsubj	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	recently	recently	RB	RB	_	11	advmod	_	_
11	cloned	clone	VBN	VBN	_	12	amod	_	_
12	member	member	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	C/EBP	c/ebp	NN	NN	_	16	compound	_	_
16	family	family	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	12	conj	_	_
23	exclusively	exclusively	RB	RB	_	25	advmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	hematopoietic	hematopoietic	JJ	JJ	_	28	amod	_	_
28	origin	origin	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	C/EBPepsilon	c/ebpepsilon	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	transcribed	transcribe	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	alternative	alternative	JJ	JJ	_	10	amod	_	_
10	promoters	promoter	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	Palpha	palpha	NN	NN	_	10	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Pbeta	pbeta	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	combination	combination	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	differential	differential	JJ	JJ	_	5	amod	_	_
5	splicing	splicing	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	alternative	alternative	JJ	JJ	_	8	amod	_	_
8	use	use	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	promoters	promoter	NNS	NNS	_	8	nmod	_	_
11	generates	generate	VBZ	VBZ	_	0	root	_	_
12	four	four	CD	CD	_	14	nummod	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	isoforms	isoform	NNS	NNS	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	of	of	IN	IN	_	18	case	_	_
17	2.6	2.6	CD	CD	_	18	nummod	_	_
18	kb	kb	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	1.3-1.5	1.3-1.5	CD	CD	_	21	nummod	_	_
21	kb	kb	NN	NN	_	18	conj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	size	size	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	transcripts	transcript	NNS	NNS	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	encode	encode	VB	VB	_	0	root	_	_
5	three	three	CD	CD	_	6	nummod	_	_
6	proteins	protein	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	calculated	calculate	VBN	VBN	_	10	amod	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	mass	mass	NN	NN	_	6	nmod	_	_
11	32.2	32.2	CD	CD	_	12	nummod	_	_
12	kDa	kda	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	27.8	27.8	CD	CD	_	15	nummod	_	_
15	kDa	kda	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	14.3	14.3	CD	CD	_	19	nummod	_	_
19	kDa	kda	NN	NN	_	12	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	Accordingly	accordingly	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	Western	western	NN	NN	_	4	compound	_	_
4	blots	blot	NNS	NNS	_	20	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	antibodies	antibody	NNS	NNS	_	4	nmod	_	_
7	specific	specific	JJ	JJ	_	6	amod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	common	common	JJ	JJ	_	11	acl:relcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	all	all	DT	DT	_	18	det	_	_
18	forms	form	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	identify	identify	VBP	VBP	_	0	root	_	_
21	multiple	multiple	JJ	JJ	_	22	amod	_	_
22	proteins	protein	NNS	NNS	_	20	dobj	_	_
23	.	.	.	.	_	20	punct	_	_

1	C/EBPepsilon	c/ebpepsilon	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	greatly	greatly	RB	RB	_	5	advmod	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	during	during	IN	IN	_	10	case	_	_
7	in	in	FW	FW	_	10	amod	_	_
8	vitro	vitro	FW	FW	_	7	dep	_	_
9	granulocytic	granulocytic	JJ	JJ	_	7	dep	_	_
10	differentiation	differentiation	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	primary	primary	JJ	JJ	_	15	amod	_	_
14	CD34(+)	cd34(+)	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	3	amod	_	_
2	acid	acid	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	HL60	hl60	NN	NN	_	8	compound	_	_
6	promyelocytic	promyelocytic	JJ	JJ	_	8	amod	_	_
7	leukemia	leukemia	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	24	24	CD	CD	_	11	nummod	_	_
11	hr	hr	NN	NN	_	3	nmod	_	_
12	induced	induce	VBD	VBD	_	0	root	_	_
13	C/EBPepsilon	c/ebpepsilon	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	12	dobj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	4-fold	4-fold	RB	RB	_	12	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	while	while	IN	IN	_	23	mark	_	_
20	prolonged	prolonged	JJ	JJ	_	21	amod	_	_
21	treatment	treatment	NN	NN	_	23	nsubj	_	_
22	gradually	gradually	RB	RB	_	23	advmod	_	_
23	reduced	reduce	VBD	VBD	_	12	advcl	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	pretreatment	pretreatment	JJ	JJ	_	28	amod	_	_
28	levels	level	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	12	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	vectors	vector	NNS	NNS	_	3	nmod	_	_
7	for	for	IN	IN	_	8	case	_	_
8	two	two	CD	CD	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	isoforms	isoform	NNS	NNS	_	8	nmod	_	_
12	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	32.2-kDa	32.2-kda	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	19	nsubj	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	an	a	DT	DT	_	19	det	_	_
19	activator	activator	NN	NN	_	12	ccomp	_	_
20	of	of	IN	IN	_	21	case	_	_
21	transcription	transcription	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	granulocyte	granulocyte	NN	NN	_	27	compound	_	_
24	colony-stimulating	colony-stimulating	JJ	JJ	_	27	amod	_	_
25	factor	factor	NN	NN	_	27	compound	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	21	nmod	_	_
28	,	,	,	,	_	19	punct	_	_
29	while	while	IN	IN	_	33	mark	_	_
30	the	the	DT	DT	_	32	det	_	_
31	14.3-kDa	14.3-kda	JJ	JJ	_	32	amod	_	_
32	protein	protein	NN	NN	_	33	nsubj	_	_
33	is	be	VBZ	VBZ	_	19	advcl	_	_
34	not	not	RB	RB	_	33	neg	_	_
35	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	C/EBPepsilon	c/ebpepsilon	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	regulated	regulate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	complex	complex	JJ	JJ	_	9	amod	_	_
9	fashion	fashion	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	play	play	VB	VB	_	5	conj	_	_
13	a	a	DT	DT	_	14	det	_	_
14	role	role	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regulation	regulation	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	genes	gene	NNS	NNS	_	17	nmod	_	_
20	involved	involve	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	myeloid	myeloid	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	localization	localization	NN	NN	_	2	conj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	ETS	ets	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	2	nmod	_	_
11	Elf-1	elf-1	NN	NN	_	10	dep	_	_
12	.	.	.	.	_	2	punct	_	_

1	Elf-1	elf-1	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	lymphoid-specific	lymphoid-specific	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	belongs	belong	VBZ	VBZ	_	6	acl:relcl	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	ETS	ets	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	bind	bind	VB	VB	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	target	target	NN	NN	_	7	compound	_	_
7	sequences	sequence	NNS	NNS	_	3	nmod	_	_
8	within	within	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	variety	variety	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	Elf-1	elf-1	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	constitutively	constitutively	RB	RB	_	7	advmod	_	_
7	localized	localized	JJ	JJ	_	2	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nucleus	nucleus	NN	NN	_	7	nmod	_	_
11	which	which	WDT	WDT	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	dependent	dependent	JJ	JJ	_	10	acl:relcl	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	amino	amino	NN	NN	_	19	compound	_	_
19	acids	acid	NNS	NNS	_	16	nmod	_	_
20	86-265	86-265	CD	CD	_	19	nummod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Gal4-Elf-1	gal4-elf-1	NN	NN	_	5	compound	_	_
4	fusion	fusion	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	1	nmod	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	the	the	DT	DT	_	12	det	_	_
9	N-terminal	n-terminal	JJ	JJ	_	12	amod	_	_
10	86	86	CD	CD	_	12	nummod	_	_
11	amino	amino	NN	NN	_	12	compound	_	_
12	acids	acid	NNS	NNS	_	15	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Elf-1	elf-1	NN	NN	_	12	nmod	_	_
15	contain	contain	VBP	VBP	_	6	ccomp	_	_
16	a	a	DT	DT	_	19	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
18	activation	activation	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	15	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activity	activity	NN	NN	_	26	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	22	nmod	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	attenuated	attenuate	VBN	VBN	_	19	acl:relcl	_	_
27	by	by	IN	IN	_	31	case	_	_
28	an	a	DT	DT	_	31	det	_	_
29	internal	internal	JJ	JJ	_	31	amod	_	_
30	repression	repression	NN	NN	_	31	compound	_	_
31	domain	domain	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Elf-1	elf-1	NN	NN	_	4	nsubj	_	_
4	interacts	interact	VBZ	VBZ	_	0	root	_	_
5	specifically	specifically	RB	RB	_	10	advmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	E74	e74	NN	NN	_	10	compound	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	sequence	sequence	NN	NN	_	4	nmod	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	stimulate	stimulate	VB	VB	_	4	conj	_	_
14	transcription	transcription	NN	NN	_	13	dobj	_	_
15	driven	drive	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	E74	e74	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	15	nmod	_	_
20	independent	independent	JJ	JJ	_	19	amod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	mitogenic	mitogenic	JJ	JJ	_	23	amod	_	_
23	signaling	signaling	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Elf-1	elf-1	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	stimulate	stimulate	VB	VB	_	5	xcomp	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	which	which	WDT	WDT	_	13	nsubjpass	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	required	require	VBN	VBN	_	9	acl:relcl	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	development	development	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	activity	activity	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Histamine	histamine	NN	NN	_	2	nsubj	_	_
2	modulates	modulate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	c-fos	c-fos	NN	NN	_	4	nmod	_	_
7	through	through	IN	IN	_	10	case	_	_
8	cyclic	cyclic	JJ	JJ	_	10	amod	_	_
9	AMP	amp	NN	NN	_	10	compound	_	_
10	production	production	NN	NN	_	4	nmod	_	_
11	via	via	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	H2	h2	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	det	_	_
17	human	human	JJ	JJ	_	21	amod	_	_
18	promonocytic	promonocytic	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	line	line	NN	NN	_	21	compound	_	_
21	U937	u937	NN	NN	_	4	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	histamine	histamine	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	agonists	agonist	NNS	NNS	_	6	conj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	c-fos	c-fos	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	c-myc	c-myc	NN	NN	_	15	conj	_	_
18	proto-oncogenes	proto-oncogene	NNS	NNS	_	15	dep	_	_
19	at	at	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	transcriptional	transcriptional	JJ	JJ	_	12	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	translational	translational	JJ	JJ	_	21	conj	_	_
24	levels	level	NNS	NNS	_	21	dep	_	_
25	in	in	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	det	_	_
27	human	human	JJ	JJ	_	31	amod	_	_
28	promonocytic	promonocytic	JJ	JJ	_	31	amod	_	_
29	U937	u937	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	line	line	NN	NN	_	12	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Histamine	histamine	NN	NN	_	3	nsubj	_	_
2	transiently	transiently	RB	RB	_	3	advmod	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	cAMP	camp	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-fos	c-fos	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	conj	_	_
8	through	through	IN	IN	_	10	case	_	_
9	H2	h2	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Dibutyryl	dibutyryl	NN	NN	_	2	compound	_	_
2	cAMP	camp	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	increased	increase	VBD	VBD	_	0	root	_	_
5	c-fos	c-fos	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	protein	protein	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	levels	level	NNS	NNS	_	12	nsubj	_	_
12	remained	remain	VBD	VBD	_	4	conj	_	_
13	elevated	elevated	JJ	JJ	_	12	xcomp	_	_
14	even	even	RB	RB	_	17	advmod	_	_
15	after	after	IN	IN	_	17	case	_	_
16	12	12	CD	CD	_	17	nummod	_	_
17	hr	hr	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	treatment	treatment	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Dose-dependence	dose-dependence	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	7	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	histamine	histamine	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	dimaprit	dimaprit	NN	NN	_	4	conj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	the	the	DT	DT	_	11	det	_	_
10	EC50	ec50	NN	NN	_	11	compound	_	_
11	values	value	NNS	NNS	_	19	nsubj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	cAMP	camp	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	c-fos	c-fos	NN	NN	_	17	compound	_	_
17	increase	increase	NN	NN	_	14	conj	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	similar	similar	JJ	JJ	_	7	ccomp	_	_
20	,	,	,	,	_	7	punct	_	_
21	suggesting	suggest	VBG	VBG	_	7	xcomp	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	cAMP	camp	NN	NN	_	26	nsubjpass	_	_
24	might	might	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	involved	involve	VBN	VBN	_	21	ccomp	_	_
27	in	in	IN	IN	_	29	case	_	_
28	c-fos	c-fos	NN	NN	_	29	compound	_	_
29	induction	induction	NN	NN	_	26	nmod	_	_
30	via	via	IN	IN	_	32	case	_	_
31	H2	h2	NN	NN	_	32	compound	_	_
32	receptors	receptor	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	studies	study	NNS	NNS	_	17	nsubj	_	_
4	carried	carry	VBD	VBD	_	3	acl	_	_
5	out	out	IN	IN	_	4	compound:prt	_	_
6	using	use	VBG	VBG	_	4	xcomp	_	_
7	H7	h7	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	15	det	_	_
10	protein	protein	NN	NN	_	15	compound	_	_
11	kinase	kinase	NN	NN	_	15	compound	_	_
12	A/protein	a/protein	NN	NN	_	15	compound	_	_
13	kinase	kinase	NN	NN	_	15	compound	_	_
14	C	c	NN	NN	_	15	compound	_	_
15	inhibitor	inhibitor	NN	NN	_	7	appos	_	_
16	,	,	,	,	_	3	punct	_	_
17	blocked	block	VBD	VBD	_	0	root	_	_
18	c-fos	c-fos	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	17	dobj	_	_
20	,	,	,	,	_	17	punct	_	_
21	whereas	whereas	IN	IN	_	25	mark	_	_
22	no	no	DT	DT	_	23	neg	_	_
23	effect	effect	NN	NN	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	observed	observe	VBN	VBN	_	17	advcl	_	_
26	with	with	IN	IN	_	27	case	_	_
27	bisindolylmaleimide	bisindolylmaleimide	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	a	a	DT	DT	_	34	det	_	_
30	specific	specific	JJ	JJ	_	34	amod	_	_
31	protein	protein	NN	NN	_	33	compound	_	_
32	kinase	kinase	NN	NN	_	33	compound	_	_
33	C	c	NN	NN	_	34	compound	_	_
34	inhibitor	inhibitor	NN	NN	_	27	appos	_	_
35	.	.	.	.	_	17	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	modification	modification	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-myc	c-myc	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	on	on	IN	IN	_	10	case	_	_
10	treatment	treatment	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	histamine	histamine	NN	NN	_	10	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	analogues	analogue	NNS	NNS	_	12	conj	_	_
16	.	.	.	.	_	8	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	dibutyryl	dibutyryl	JJ	JJ	_	4	amod	_	_
4	cAMP	camp	NN	NN	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	down-regulation	down-regulation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	proto-oncogene	proto-oncogene	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	dibutyryl	dibutyryl	JJ	JJ	_	5	amod	_	_
5	cAMP	camp	NN	NN	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	growth	growth	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	dose-dependent	dose-dependent	JJ	JJ	_	12	amod	_	_
12	manner	manner	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	whereas	whereas	IN	IN	_	16	mark	_	_
15	histamine	histamine	NN	NN	_	16	nsubj	_	_
16	failed	fail	VBD	VBD	_	6	advcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	affect	affect	VB	VB	_	16	xcomp	_	_
19	proliferation	proliferation	NN	NN	_	18	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	differentiation	differentiation	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	U937	u937	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Cells	cell	NNS	NNS	_	5	nsubj	_	_
2	pretreated	pretreated	JJ	JJ	_	1	amod	_	_
3	with	with	IN	IN	_	4	case	_	_
4	dimaprit	dimaprit	NN	NN	_	2	nmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	decrease	decrease	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cAMP	camp	NN	NN	_	11	compound	_	_
11	response	response	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
14	addition	addition	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	H2	h2	NN	NN	_	17	compound	_	_
17	agonists	agonist	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	whereas	whereas	IN	IN	_	26	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	cAMP	camp	NN	NN	_	22	compound	_	_
22	response	response	NN	NN	_	26	nsubj	_	_
23	to	to	TO	TO	_	25	case	_	_
24	prostaglandin	prostaglandin	NN	NN	_	25	compound	_	_
25	E2	e2	NN	NN	_	22	nmod	_	_
26	remained	remain	VBD	VBD	_	5	advcl	_	_
27	unaltered	unaltered	JJ	JJ	_	26	xcomp	_	_
28	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	homologous	homologous	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	H2	h2	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	desensitization	desensitization	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	time	time	NN	NN	_	0	root	_	_
10	dependent	dependent	JJ	JJ	_	9	amod	_	_
11	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	histamine	histamine	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
7	several	several	JJ	JJ	_	8	amod	_	_
8	mechanisms	mechanism	NNS	NNS	_	6	dobj	_	_
9	involved	involve	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	induction	induction	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	differentiation	differentiation	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	such	such	JJ	JJ	_	18	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	cAMP	camp	NN	NN	_	8	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	c-fos	c-fos	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	18	conj	_	_
22	,	,	,	,	_	6	punct	_	_
23	but	but	CC	CC	_	6	cc	_	_
24	fails	fail	VBZ	VBZ	_	6	conj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	promote	promote	VB	VB	_	24	xcomp	_	_
27	differentiation	differentiation	NN	NN	_	26	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	U937	u937	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	,	,	,	,	_	24	punct	_	_
32	apparently	apparently	RB	RB	_	33	advmod	_	_
33	due	due	JJ	JJ	_	24	advmod	_	_
34	to	to	TO	TO	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	rapid	rapid	JJ	JJ	_	37	amod	_	_
37	desensitization	desensitization	NN	NN	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	H2	h2	NN	NN	_	40	compound	_	_
40	receptors	receptor	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	cytomegalovirus	cytomegalovirus	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	interleukin-8	interleukin-8	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	monocytic	monocytic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	THP-1	thp-1	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	3	punct	_	_
15	through	through	IN	IN	_	16	mark	_	_
16	acting	act	VBG	VBG	_	3	advcl	_	_
17	concurrently	concurrently	RB	RB	_	16	advmod	_	_
18	on	on	IN	IN	_	19	case	_	_
19	AP-1-	ap-1-	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	19	conj	_	_
22	sites	site	NNS	NNS	_	19	dep	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	interleukin-8	interleukin-8	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Cytomegalovirus	cytomegalovirus	NN	NN	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CMV	cmv	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	infection	infection	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	interleukin-8	interleukin-8	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IL-8	il-8	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	6	dobj	_	_
13	in	in	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	THP-1	thp-1	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	appos	_	_
22	,	,	,	,	_	6	punct	_	_
23	leading	lead	VBG	VBG	_	6	advcl	_	_
24	to	to	TO	TO	_	26	case	_	_
25	IL-8	il-8	NN	NN	_	26	compound	_	_
26	secretion	secretion	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-8	il-8	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	17	mark	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	AP-1-	ap-1-	NN	NN	_	17	nsubjpass	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	11	conj	_	_
14	factor-binding	factor-binding	JJ	JJ	_	13	amod	_	_
15	elements	element	NNS	NNS	_	11	dep	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	involved	involve	VBN	VBN	_	8	ccomp	_	_
18	in	in	IN	IN	_	19	mark	_	_
19	conferring	confer	VBG	VBG	_	17	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	responsiveness	responsiveness	NN	NN	_	19	dobj	_	_
22	to	to	TO	TO	_	23	case	_	_
23	CMV	cmv	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	electrophoretic	electrophoretic	JJ	JJ	_	6	amod	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	assays	assay	NNS	NNS	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	CMV	cmv	NN	NN	_	10	nsubj	_	_
10	induced	induce	VBD	VBD	_	7	ccomp	_	_
11	the	the	DT	DT	_	12	det	_	_
12	formation	formation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	AP-1	ap-1	NN	NN	_	17	compound	_	_
17	complexes	complex	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	CMV	cmv	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
7	these	these	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	resulting	result	VBG	VBG	_	6	advcl	_	_
12	in	in	IN	IN	_	15	case	_	_
13	IL-8	il-8	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Concomitant	concomitant	JJ	JJ	_	2	amod	_	_
2	downregulation	downregulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	IgH	igh	NN	NN	_	6	compound	_	_
5	3'	3'	JJ	JJ	_	6	amod	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	c-myc	c-myc	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	conj	_	_
11	in	in	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	plasmacytoma	plasmacytoma	NN	NN	_	16	compound	_	_
14	x	x	NN	NN	_	16	compound	_	_
15	fibroblast	fibroblast	NN	NN	_	16	compound	_	_
16	environment	environment	NN	NN	_	7	nmod	_	_
17	:	:	:	:	_	2	punct	_	_
18	implications	implication	NNS	NNS	_	2	dep	_	_
19	for	for	IN	IN	_	20	case	_	_
20	dysregulation	dysregulation	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	translocated	translocate	VBN	VBN	_	23	amod	_	_
23	c-myc	c-myc	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	10	case	_	_
3	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
4	heavy	heavy	JJ	JJ	_	9	amod	_	_
5	chain	chain	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	IgH	igh	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	1	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	controlled	control	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	cell-specific	cell-specific	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	intronic	intronic	JJ	JJ	_	20	amod	_	_
20	enhancer	enhancer	NN	NN	_	17	conj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	additional	additional	JJ	JJ	_	26	amod	_	_
23	B	b	NN	NN	_	26	compound	_	_
24	cell-specific	cell-specific	JJ	JJ	_	26	amod	_	_
25	enhancer	enhancer	NN	NN	_	26	compound	_	_
26	elements	element	NNS	NNS	_	17	conj	_	_
27	identified	identify	VBN	VBN	_	26	acl	_	_
28	recently	recently	RB	RB	_	27	advmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	3'	3'	JJ	JJ	_	32	amod	_	_
32	end	end	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	IgH	igh	NN	NN	_	36	compound	_	_
36	locus	locus	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	One	one	CD	CD	_	15	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	latter	latter	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	the	the	DT	DT	_	10	det	_	_
8	IgH	igh	NN	NN	_	10	compound	_	_
9	3'	3'	JJ	JJ	_	10	amod	_	_
10	enhancer	enhancer	NN	NN	_	1	appos	_	_
11	,	,	,	,	_	1	punct	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	of	of	IN	IN	_	15	case	_	_
14	particular	particular	JJ	JJ	_	15	amod	_	_
15	interest	interest	NN	NN	_	0	root	_	_
16	:	:	:	:	_	15	punct	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	1	1	LS	LS	_	23	dep	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	it	it	PRP	PRP	_	23	nsubj	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	B	b	NN	NN	_	23	nmod:npmod	_	_
23	cell-specific	cell-specific	JJ	JJ	_	15	parataxis	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	active	active	JJ	JJ	_	23	conj	_	_
26	only	only	RB	RB	_	31	advmod	_	_
27	in	in	IN	IN	_	31	case	_	_
28	late	late	JJ	JJ	_	31	amod	_	_
29	B	b	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	development	development	NN	NN	_	25	nmod	_	_
32	;	;	:	:	_	23	punct	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	2	2	LS	LS	_	48	dep	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	in	in	IN	IN	_	38	case	_	_
37	rodent	rodent	JJ	JJ	_	38	amod	_	_
38	plasmacytomas	plasmacytoma	NNS	NNS	_	48	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	in	in	IN	IN	_	45	case	_	_
41	some	some	DT	DT	_	45	det	_	_
42	human	human	JJ	JJ	_	45	amod	_	_
43	Burkitt	burkitt	NN	NN	_	45	nmod:poss	_	_
44	's	's	POS	POS	_	43	case	_	_
45	lymphomas	lymphoma	NNS	NNS	_	38	conj	_	_
46	it	it	PRP	PRP	_	48	nsubj	_	_
47	is	be	VBZ	VBZ	_	48	cop	_	_
48	part	part	NN	NN	_	23	conj	_	_
49	of	of	IN	IN	_	53	case	_	_
50	a	a	DT	DT	_	53	det	_	_
51	locus	locus	NN	NN	_	53	compound	_	_
52	control	control	NN	NN	_	53	compound	_	_
53	region	region	NN	NN	_	48	nmod	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	LCR	lcr	NN	NN	_	53	appos	_	_
56	)	)	-RRB-	-RRB-	_	55	punct	_	_
57	that	that	WDT	WDT	_	59	nsubjpass	_	_
58	is	be	VBZ	VBZ	_	59	auxpass	_	_
59	involved	involve	VBN	VBN	_	53	acl:relcl	_	_
60	in	in	IN	IN	_	61	case	_	_
61	deregulation	deregulation	NN	NN	_	59	nmod	_	_
62	of	of	IN	IN	_	65	case	_	_
63	the	the	DT	DT	_	65	det	_	_
64	c-myc	c-myc	NN	NN	_	65	compound	_	_
65	oncogene	oncogene	NN	NN	_	61	nmod	_	_
66	as	as	IN	IN	_	68	case	_	_
67	a	a	DT	DT	_	68	det	_	_
68	result	result	NN	NN	_	48	nmod	_	_
69	of	of	IN	IN	_	70	case	_	_
70	translocation	translocation	NN	NN	_	68	nmod	_	_
71	into	into	IN	IN	_	74	case	_	_
72	the	the	DT	DT	_	74	det	_	_
73	IgH	igh	NN	NN	_	74	compound	_	_
74	locus	locus	NN	NN	_	70	nmod	_	_
75	;	;	:	:	_	23	punct	_	_
76	and	and	CC	CC	_	23	cc	_	_
77	(	(	-LRB-	-LRB-	_	78	punct	_	_
78	3	3	LS	LS	_	83	dep	_	_
79	)	)	-RRB-	-RRB-	_	78	punct	_	_
80	it	it	PRP	PRP	_	83	nsubjpass	_	_
81	has	have	VBZ	VBZ	_	83	aux	_	_
82	been	be	VBN	VBN	_	83	auxpass	_	_
83	implicated	implicate	VBN	VBN	_	23	conj	_	_
84	in	in	IN	IN	_	86	case	_	_
85	the	the	DT	DT	_	86	det	_	_
86	mechanisms	mechanism	NNS	NNS	_	83	nmod	_	_
87	that	that	WDT	WDT	_	88	nsubj	_	_
88	control	control	VBP	VBP	_	86	acl:relcl	_	_
89	Ig	ig	NN	NN	_	91	compound	_	_
90	gene	gene	NN	NN	_	91	compound	_	_
91	class	class	NN	NN	_	93	compound	_	_
92	switch	switch	NN	NN	_	93	compound	_	_
93	recombination	recombination	NN	NN	_	88	dobj	_	_
94	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	somatic	somatic	JJ	JJ	_	8	amod	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	hybridization	hybridization	NN	NN	_	8	compound	_	_
8	approach	approach	NN	NN	_	3	dobj	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	genetically	genetically	RB	RB	_	11	advmod	_	_
11	analyse	analyse	VB	VB	_	3	xcomp	_	_
12	regulation	regulation	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	IgH	igh	NN	NN	_	20	compound	_	_
19	3'	3'	JJ	JJ	_	20	amod	_	_
20	enhancer	enhancer	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	17	advmod	_	_
2	mouse	mouse	NN	NN	_	5	compound	_	_
3	MPC11	mpc11	NN	NN	_	5	compound	_	_
4	plasmacytoma	plasmacytoma	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	17	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	14	nmod	_	_
9	the	the	DT	DT	_	12	det	_	_
10	IgH	igh	NN	NN	_	12	compound	_	_
11	3'	3'	JJ	JJ	_	12	amod	_	_
12	enhancer	enhancer	NN	NN	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	active	active	JJ	JJ	_	5	acl:relcl	_	_
15	,	,	,	,	_	5	punct	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	fused	fuse	VBN	VBN	_	24	advcl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	fibroblasts	fibroblast	NNS	NNS	_	17	nmod	_	_
20	,	,	,	,	_	24	punct	_	_
21	Ig	ig	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	extinguished	extinguish	VBN	VBN	_	0	root	_	_
25	at	at	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	level	level	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	transcription	transcription	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	24	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	in	in	IN	IN	_	11	case	_	_
6	a	a	DT	DT	_	11	det	_	_
7	MPC11	mpc11	NN	NN	_	11	compound	_	_
8	plasmacytoma	plasmacytoma	NN	NN	_	11	compound	_	_
9	x	x	NN	NN	_	11	compound	_	_
10	fibroblast	fibroblast	NN	NN	_	11	compound	_	_
11	environment	environment	NN	NN	_	19	nmod	_	_
12	,	,	,	,	_	19	punct	_	_
13	the	the	DT	DT	_	16	det	_	_
14	IgH	igh	NN	NN	_	16	compound	_	_
15	3'	3'	JJ	JJ	_	16	amod	_	_
16	enhancer	enhancer	NN	NN	_	19	nsubj	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	transcriptionally	transcriptionally	RB	RB	_	19	advmod	_	_
19	inactive	inactive	JJ	JJ	_	3	ccomp	_	_
20	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	22	mark	_	_
6	binding	binding	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	several	several	JJ	JJ	_	12	amod	_	_
9	B	b	NN	NN	_	12	compound	_	_
10	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	essential	essential	JJ	JJ	_	12	amod	_	_
15	for	for	IN	IN	_	19	case	_	_
16	IgH	igh	NN	NN	_	18	compound	_	_
17	3'	3'	JJ	JJ	_	18	amod	_	_
18	enhancer	enhancer	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	is	be	VBZ	VBZ	_	22	aux	_	_
22	lacking	lack	VBG	VBG	_	4	ccomp	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	explain	explain	VB	VB	_	22	ccomp	_	_
27	3'	3'	JJ	JJ	_	29	amod	_	_
28	enhancer	enhancer	NN	NN	_	29	compound	_	_
29	inactivity	inactivity	NN	NN	_	26	dobj	_	_
30	,	,	,	,	_	22	punct	_	_
31	although	although	IN	IN	_	39	mark	_	_
32	the	the	DT	DT	_	33	det	_	_
33	binding	binding	NN	NN	_	39	nsubjpass	_	_
34	of	of	IN	IN	_	35	case	_	_
35	repressors	repressor	NNS	NNS	_	33	nmod	_	_
36	can	can	MD	MD	_	39	aux	_	_
37	not	not	RB	RB	_	39	neg	_	_
38	be	be	VB	VB	_	39	auxpass	_	_
39	excluded	exclude	VBN	VBN	_	22	advcl	_	_
40	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	high	high	JJ	JJ	_	6	amod	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	level	level	NN	NN	_	22	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	c-myc	c-myc	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	characteristic	characteristic	JJ	JJ	_	6	advmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	parental	parental	JJ	JJ	_	15	amod	_	_
14	MPC11	mpc11	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	carrying	carry	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	t(12;15)	t(12;15)	NN	NN	_	19	compound	_	_
19	translocation	translocation	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	6	punct	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	hybrids	hybrid	NNS	NNS	_	22	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	that	that	DT	DT	_	22	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	unfused	unfused	JJ	JJ	_	30	amod	_	_
30	fibroblasts	fibroblast	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	22	punct	_	_

1	Therefore	therefore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	inactivation	inactivation	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	IgH	igh	NN	NN	_	8	compound	_	_
7	3'	3'	JJ	JJ	_	8	amod	_	_
8	enhancer	enhancer	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	multifactorial	multifactorial	JJ	JJ	_	12	amod	_	_
12	process	process	NN	NN	_	0	root	_	_
13	affecting	affect	VBG	VBG	_	12	acl	_	_
14	several	several	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	13	dobj	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	control	control	VBP	VBP	_	16	acl:relcl	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	cell-specific	cell-specific	JJ	JJ	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	developmental	developmental	JJ	JJ	_	20	conj	_	_
23	activity	activity	NN	NN	_	20	dep	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	enhancer	enhancer	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Construction	construction	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	biological	biological	JJ	JJ	_	4	amod	_	_
4	characterization	characterization	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	interleukin-12	interleukin-12	NN	NN	_	9	compound	_	_
8	fusion	fusion	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Flexi-12	flexi-12	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	:	:	:	:	_	1	punct	_	_
14	delivery	delivery	NN	NN	_	1	dep	_	_
15	to	to	TO	TO	_	19	case	_	_
16	acute	acute	JJ	JJ	_	19	amod	_	_
17	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
18	leukemic	leukemic	JJ	JJ	_	19	amod	_	_
19	blasts	blast	NNS	NNS	_	14	nmod	_	_
20	using	use	VBG	VBG	_	14	dep	_	_
21	adeno-associated	adeno-associated	JJ	JJ	_	22	amod	_	_
22	virus	virus	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	1	punct	_	_

1	Interleukin-12	interleukin-12	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-12	il-12	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	cytokine	cytokine	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	exhibits	exhibit	VBZ	VBZ	_	7	acl:relcl	_	_
10	pleiotropic	pleiotropic	JJ	JJ	_	11	amod	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	on	on	IN	IN	_	13	case	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	natural	natural	JJ	JJ	_	17	amod	_	_
16	killer	killer	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	conj	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	has	have	VBZ	VBZ	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	shown	show	VBN	VBN	_	9	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	have	have	VB	VB	_	21	xcomp	_	_
24	promise	promise	NN	NN	_	23	dobj	_	_
25	for	for	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	immunotherapy	immunotherapy	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	cancer	cancer	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	combination	combination	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	immune	immune	JJ	JJ	_	7	amod	_	_
6	costimulatory	costimulatory	JJ	JJ	_	7	amod	_	_
7	molecule	molecule	NN	NN	_	2	nmod	_	_
8	B7.1	b7.1	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-12	il-12	NN	NN	_	8	conj	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	shown	show	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	synergistic	synergistic	JJ	JJ	_	13	xcomp	_	_
17	for	for	IN	IN	_	20	case	_	_
18	T	t	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	transfecting	transfect	VBG	VBG	_	15	advcl	_	_
3	tumor	tumor	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	2	dobj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	IL-12	il-12	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	B7.1	b7.1	NN	NN	_	7	conj	_	_
10	cDNAs	cdna	NNS	NNS	_	7	dep	_	_
11	,	,	,	,	_	15	punct	_	_
12	it	it	PRP	PRP	_	15	nsubj	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	possible	possible	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	use	use	VB	VB	_	15	xcomp	_	_
18	these	these	DT	DT	_	20	det	_	_
19	modified	modify	VBN	VBN	_	20	amod	_	_
20	targets	target	NNS	NNS	_	17	dobj	_	_
21	as	as	IN	IN	_	22	case	_	_
22	vaccines	vaccine	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	major	major	JJ	JJ	_	3	amod	_	_
3	obstacle	obstacle	NN	NN	_	12	nsubj	_	_
4	in	in	IN	IN	_	5	mark	_	_
5	designing	design	VBG	VBG	_	3	acl	_	_
6	a	a	DT	DT	_	7	det	_	_
7	vector	vector	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	deliver	deliver	VB	VB	_	5	xcomp	_	_
10	these	these	DT	DT	_	11	det	_	_
11	genes	gene	NNS	NNS	_	9	dobj	_	_
12	results	result	VBZ	VBZ	_	0	root	_	_
13	from	from	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	structure	structure	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IL-12	il-12	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	IL-12	il-12	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	a	a	DT	DT	_	5	det	_	_
5	heterodimer	heterodimer	NN	NN	_	0	root	_	_
6	composed	compose	VBN	VBN	_	5	acl	_	_
7	of	of	IN	IN	_	10	case	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	distinct	distinct	JJ	JJ	_	10	amod	_	_
10	subunits	subunit	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	encoded	encode	VBN	VBN	_	10	acl:relcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	separate	separate	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	on	on	IN	IN	_	19	case	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	chromosomes	chromosome	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Production	production	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	functional	functional	JJ	JJ	_	4	amod	_	_
4	IL-12	il-12	NN	NN	_	1	nmod	_	_
5	requires	require	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	coordinated	coordinate	VBN	VBN	_	8	amod	_	_
8	expression	expression	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	both	both	DT	DT	_	11	det	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	presents	present	VBZ	VBZ	_	0	root	_	_
3	several	several	JJ	JJ	_	4	amod	_	_
4	problems	problem	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	vectors	vector	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	particularly	particularly	RB	RB	_	9	advmod	_	_
9	those	those	DT	DT	_	6	appos	_	_
10	in	in	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	25	nmod	_	_
12	additional	additional	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	25	nsubjpass	_	_
14	,	,	,	,	_	13	punct	_	_
15	either	either	CC	CC	_	18	cc:preconj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	co-stimulatory	co-stimulatory	JJ	JJ	_	18	amod	_	_
18	gene	gene	NN	NN	_	13	appos	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	a	a	DT	DT	_	22	det	_	_
21	selectable	selectable	JJ	JJ	_	22	amod	_	_
22	marker	marker	NN	NN	_	18	conj	_	_
23	,	,	,	,	_	13	punct	_	_
24	are	be	VBP	VBP	_	25	auxpass	_	_
25	inserted	insert	VBN	VBN	_	9	acl:relcl	_	_
26	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	constructed	construct	VBN	VBN	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	single	single	JJ	JJ	_	8	amod	_	_
8	cDNA	cdna	NN	NN	_	5	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	encodes	encode	VBZ	VBZ	_	8	acl:relcl	_	_
11	a	a	DT	DT	_	13	det	_	_
12	single-chain	single-chain	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	8	punct	_	_
15	called	call	VBN	VBN	_	8	acl	_	_
16	Flexi-12	flexi-12	NN	NN	_	15	xcomp	_	_
17	,	,	,	,	_	8	punct	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	retains	retain	VBZ	VBZ	_	8	acl:relcl	_	_
20	all	all	DT	DT	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	biological	biological	JJ	JJ	_	24	amod	_	_
24	characteristics	characteristic	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	recombinant	recombinant	JJ	JJ	_	27	amod	_	_
27	IL-12	il-12	NN	NN	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	rIL-12	ril-12	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	monomeric	monomeric	JJ	JJ	_	3	amod	_	_
3	polypeptide	polypeptide	NN	NN	_	6	nsubj	_	_
4	Flexi-12	flexi-12	NN	NN	_	3	dep	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	able	able	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	induce	induce	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	proliferation	proliferation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	phytohemagglutinin	phytohemagglutinin	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	PHA	pha	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	blasts	blast	NNS	NNS	_	10	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	induce	induce	VB	VB	_	8	conj	_	_
19	PHA	pha	NN	NN	_	20	compound	_	_
20	blasts	blast	NNS	NNS	_	18	dobj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	secrete	secrete	VB	VB	_	18	advcl	_	_
23	interferon-gamma	interferon-gamma	NN	NN	_	22	dobj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	IFN-gamma	ifn-gamma	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	and	and	CC	CC	_	8	cc	_	_
28	additionally	additionally	RB	RB	_	8	advmod	_	_
29	,	,	,	,	_	8	punct	_	_
30	by	by	IN	IN	_	31	case	_	_
31	preincubation	preincubation	NN	NN	_	8	conj	_	_
32	,	,	,	,	_	8	punct	_	_
33	enhance	enhance	VB	VB	_	8	conj	_	_
34	the	the	DT	DT	_	35	det	_	_
35	killing	killing	NN	NN	_	33	dobj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	K562	k562	NN	NN	_	38	compound	_	_
38	targets	target	NNS	NNS	_	35	nmod	_	_
39	by	by	IN	IN	_	40	case	_	_
40	PBLs	pbl	NNS	NNS	_	35	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	phenomena	phenomenon	NNS	NNS	_	8	nsubj	_	_
3	are	be	VBP	VBP	_	8	cop	_	_
4	in	in	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	dose-dependent	dose-dependent	JJ	JJ	_	7	amod	_	_
7	manner	manner	NN	NN	_	8	nmod	_	_
8	comparable	comparable	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	case	_	_
10	that	that	DT	DT	_	8	nmod	_	_
11	seen	see	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	rIL-12	ril-12	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	28	mark	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	28	nsubj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	STAT	stat	NN	NN	_	13	compound	_	_
11	4	4	CD	CD	_	13	nummod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	18	nsubjpass	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	shown	show	VBN	VBN	_	13	acl:relcl	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	unique	unique	JJ	JJ	_	18	xcomp	_	_
22	to	to	TO	TO	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	IL-12	il-12	NN	NN	_	26	compound	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	pathway	pathway	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	7	punct	_	_
28	occurs	occur	VBZ	VBZ	_	4	ccomp	_	_
29	with	with	IN	IN	_	30	case	_	_
30	Flexi-12	flexi-12	NN	NN	_	28	nmod	_	_
31	at	at	IN	IN	_	32	case	_	_
32	levels	level	NNS	NNS	_	28	nmod	_	_
33	similar	similar	JJ	JJ	_	32	amod	_	_
34	to	to	TO	TO	_	35	case	_	_
35	those	those	DT	DT	_	33	nmod	_	_
36	seen	see	VBN	VBN	_	35	acl	_	_
37	with	with	IN	IN	_	38	case	_	_
38	rIL-12	ril-12	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	packaged	package	VBN	VBN	_	0	root	_	_
4	Flexi-12	flexi-12	NN	NN	_	3	dobj	_	_
5	into	into	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	recombinant	recombinant	JJ	JJ	_	9	amod	_	_
8	adeno-associated	adeno-associated	JJ	JJ	_	9	amod	_	_
9	virus	virus	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AAV	aav	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	used	use	VBN	VBN	_	3	conj	_	_
15	this	this	DT	DT	_	16	det	_	_
16	vector	vector	NN	NN	_	14	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	infect	infect	VB	VB	_	14	advcl	_	_
19	acute	acute	JJ	JJ	_	25	amod	_	_
20	myeloid	myeloid	JJ	JJ	_	25	amod	_	_
21	leukemic	leukemic	JJ	JJ	_	25	amod	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	AML	aml	NN	NN	_	25	compound	_	_
24	)	)	-RRB-	-RRB-	_	25	punct	_	_
25	blasts	blast	NNS	NNS	_	18	dobj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Infected	infected	JJ	JJ	_	3	amod	_	_
2	AML	aml	NN	NN	_	3	compound	_	_
3	blasts	blast	NNS	NNS	_	4	nsubj	_	_
4	produced	produce	VBD	VBD	_	0	root	_	_
5	between	between	IN	IN	_	6	amod	_	_
6	2	2	CD	CD	_	9	nummod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	6	6	CD	CD	_	6	conj	_	_
9	ng	ng	NN	NN	_	4	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	IL-12/10	il-12/10	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	6	6	CD	CD	_	15	nummod	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	per	per	IN	IN	_	17	case	_	_
17	ml	ml	NN	NN	_	9	nmod	_	_
18	per	per	IN	IN	_	20	case	_	_
19	48	48	CD	CD	_	20	nummod	_	_
20	hr	hr	NN	NN	_	4	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	confirm	confirm	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	AAV	aav	NN	NN	_	11	nsubj	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	an	a	DT	DT	_	11	det	_	_
9	efficient	efficient	JJ	JJ	_	11	amod	_	_
10	delivery	delivery	NN	NN	_	11	compound	_	_
11	vehicle	vehicle	NN	NN	_	4	ccomp	_	_
12	for	for	IN	IN	_	13	case	_	_
13	cytokines	cytokine	NNS	NNS	_	11	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	modified	modify	VBN	VBN	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	acting	act	VBG	VBG	_	6	acl	_	_
8	as	as	IN	IN	_	10	case	_	_
9	tumor	tumor	NN	NN	_	10	compound	_	_
10	vaccines	vaccine	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	underway	underway	JJ	JJ	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	ETS1	ets1	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	NFkappaB	nfkappab	NN	NN	_	1	conj	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	AP1	ap1	NN	NN	_	1	conj	_	_
6	synergistically	synergistically	RB	RB	_	7	advmod	_	_
7	transactivate	transactivate	VBP	VBP	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	GM-CSF	gm-csf	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	helper	helper	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	results	result	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	coordinate	coordinate	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
15	involved	involve	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	differentiation	differentiation	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	proliferation	proliferation	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	activation	activation	NN	NN	_	17	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	haematopoietic	haematopoietic	JJ	JJ	_	25	amod	_	_
25	system	system	NN	NN	_	17	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	4	amod	_	_
2	colony	colony	NN	NN	_	4	compound	_	_
3	stimulating	stimulating	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GM-CSF	gm-csf	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	one	one	CD	CD	_	11	nummod	_	_
10	such	such	JJ	JJ	_	11	amod	_	_
11	cytokine	cytokine	NN	NN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	whose	whose	WP$	WP$	_	15	nmod:poss	_	_
14	increased	increase	VBN	VBN	_	15	amod	_	_
15	expression	expression	NN	NN	_	16	nsubj	_	_
16	results	result	VBZ	VBZ	_	11	acl:relcl	_	_
17	mostly	mostly	RB	RB	_	19	advmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	increases	increase	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	transcription	transcription	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	Cis-acting	cis-acting	JJ	JJ	_	2	amod	_	_
2	elements	element	NNS	NNS	_	13	nsubjpass	_	_
3	with	with	IN	IN	_	4	case	_	_
4	NFkappaB	nfkappab	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	AP1	ap1	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	ETS-like	ets-like	JJ	JJ	_	4	conj	_	_
9	binding	bind	VBG	VBG	_	10	amod	_	_
10	motifs	motif	NNS	NNS	_	4	dep	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	identified	identify	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	GM-CSF	gm-csf	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	important	important	JJ	JJ	_	13	conj	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	essential	essential	JJ	JJ	_	25	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	activity	activity	NN	NN	_	25	nmod	_	_
31	following	follow	VBG	VBG	_	34	case	_	_
32	T	t	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	ETS1	ets1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	ETS	ets	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	5	nmod	_	_
10	that	that	WDT	WDT	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	5	acl:relcl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	ETS1	ets1	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	transactivate	transactivate	VB	VB	_	4	ccomp	_	_
9	GM-CSF	gm-csf	NN	NN	_	8	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Jurkat	jurkat	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	but	but	CC	CC	_	8	cc	_	_
16	only	only	RB	RB	_	22	advmod	_	_
17	after	after	IN	IN	_	22	dep	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	22	dep	_	_
20	have	have	VBP	VBP	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	stimulated	stimulate	VBN	VBN	_	8	advcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	treatment	treatment	NN	NN	_	22	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	PMA	pma	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	ionomycin	ionomycin	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	agents	agent	NNS	NNS	_	26	appos	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	mimic	mimic	VBP	VBP	_	30	acl:relcl	_	_
33	T	t	NN	NN	_	35	compound	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	activation	activation	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	proposed	propose	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	ETS1	ets1	NN	NN	_	16	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	5	acl:relcl	_	_
10	constitutively	constitutively	RB	RB	_	9	advmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	Jurkat	jurkat	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	act	act	VB	VB	_	3	ccomp	_	_
17	in	in	IN	IN	_	18	case	_	_
18	concert	concert	NN	NN	_	16	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	PMA/ionomycin	pma/ionomycin	NN	NN	_	22	compound	_	_
21	inducible	inducible	JJ	JJ	_	22	amod	_	_
22	factors	factor	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	ETS1	ets1	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	transactivate	transactivate	VB	VB	_	3	ccomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	GM-CSF	gm-csf	NN	NN	_	11	compound	_	_
10	reporter	reporter	NN	NN	_	11	compound	_	_
11	construct	construct	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	unstimulated	unstimulated	JJ	JJ	_	15	amod	_	_
14	Jurkat	jurkat	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	providing	provide	VBG	VBG	_	26	case	_	_
18	that	that	IN	IN	_	26	mark	_	_
19	either	either	CC	CC	_	20	cc:preconj	_	_
20	NFkappaB	nfkappab	NN	NN	_	26	nsubjpass	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	AP1	ap1	NN	NN	_	20	conj	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	20	dep	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	supplied	supply	VBN	VBN	_	7	advcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	co-transfection	co-transfection	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	confirm	confirm	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	binding	binding	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	endogenous	endogenous	JJ	JJ	_	7	amod	_	_
7	NFkappaB	nfkappab	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	AP1	ap1	NN	NN	_	7	conj	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	2	ccomp	_	_
12	following	follow	VBG	VBG	_	14	case	_	_
13	PMA/ionomycin	pma/ionomycin	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Transactivation	transactivation	NN	NN	_	9	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	ETS1	ets1	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	NFkappaB	nfkappab	NN	NN	_	3	conj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	AP1	ap1	NN	NN	_	3	conj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	synergistic	synergistic	JJ	JJ	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	mutation	mutation	NN	NN	_	18	nsubj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	individual	individual	JJ	JJ	_	17	amod	_	_
16	binding	bind	VBG	VBG	_	17	amod	_	_
17	sites	site	NNS	NNS	_	12	nmod	_	_
18	reveals	reveal	VBZ	VBZ	_	9	conj	_	_
19	that	that	IN	IN	_	27	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activities	activity	NNS	NNS	_	27	nsubj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	factors	factor	NNS	NNS	_	22	nmod	_	_
26	are	be	VBP	VBP	_	27	cop	_	_
27	interdependent	interdependent	JJ	JJ	_	18	ccomp	_	_
28	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
6	ETS1	ets1	NN	NN	_	14	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	inducible	inducible	JJ	JJ	_	10	amod	_	_
10	NFkappaB	nfkappab	NN	NN	_	6	conj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	AP1	ap1	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	cooperate	cooperate	VBP	VBP	_	3	ccomp	_	_
15	as	as	IN	IN	_	16	case	_	_
16	part	part	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	higher	higher	JJR	JJR	_	20	amod	_	_
20	order	order	NN	NN	_	16	nmod	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	complex	complex	NN	NN	_	20	dep	_	_
23	in	in	IN	IN	_	26	case	_	_
24	activated	activate	VBN	VBN	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	20	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Relief	relief	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	cyclin	cyclin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	7	compound	_	_
5	gene	gene	NN	NN	_	7	compound	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	inhibition	inhibition	NN	NN	_	1	nmod	_	_
8	during	during	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	1	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	primary	primary	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
15	via	via	IN	IN	_	16	case	_	_
16	CD2	cd2	NN	NN	_	9	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	CD28	cd28	NN	NN	_	16	conj	_	_
19	adhesion	adhesion	NN	NN	_	20	compound	_	_
20	molecules	molecule	NNS	NNS	_	16	dep	_	_
21	.	.	.	.	_	1	punct	_	_

1	Cyclin	cyclin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	7	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	7	auxpass	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	cycle	cycle	NN	NN	_	7	nmod:npmod	_	_
7	regulated	regulated	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	induced	induce	VBN	VBN	_	7	conj	_	_
10	by	by	IN	IN	_	13	case	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	proliferative	proliferative	JJ	JJ	_	13	amod	_	_
13	signals	signal	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	underlined	underline	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	normal	normal	JJ	JJ	_	12	amod	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	have	have	VBP	VBP	_	16	aux	_	_
16	analysed	analyse	VBN	VBN	_	2	parataxis	_	_
17	in	in	FW	FW	_	20	amod	_	_
18	vivo	vivo	FW	FW	_	17	dep	_	_
19	protein-DNA	protein-dna	JJ	JJ	_	20	amod	_	_
20	interactions	interaction	NNS	NNS	_	16	dobj	_	_
21	at	at	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	Cyclin	cyclin	NN	NN	_	24	compound	_	_
24	A	a	NN	NN	_	25	compound	_	_
25	locus	locus	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	primary	primary	JJ	JJ	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	purified	purify	VBN	VBN	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	combination	combination	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	monoclonal	monoclonal	JJ	JJ	_	11	amod	_	_
11	antibodies	antibody	NNS	NNS	_	8	nmod	_	_
12	directed	direct	VBN	VBN	_	1	acl	_	_
13	at	at	IN	IN	_	14	case	_	_
14	CD2	cd2	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	CD28	cd28	NN	NN	_	14	conj	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecules	molecule	NNS	NNS	_	14	dep	_	_
19	gives	give	VBZ	VBZ	_	0	root	_	_
20	rise	rise	NN	NN	_	19	dobj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	long	long	JJ	JJ	_	24	amod	_	_
24	lasting	lasting	JJ	JJ	_	25	amod	_	_
25	proliferation	proliferation	NN	NN	_	19	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	absence	absence	NN	NN	_	19	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	accessory	accessory	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	19	punct	_	_

1	Cyclin	cyclin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	after	after	IN	IN	_	7	case	_	_
6	4	4	CD	CD	_	7	nummod	_	_
7	days	day	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	costimulation	costimulation	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	anti	anti	JJ	JJ	_	12	amod	_	_
12	CD2	cd2	NN	NN	_	9	nmod	_	_
13	+	+	CC	CC	_	12	cc	_	_
14	CD28	cd28	NN	NN	_	12	conj	_	_
15	whereas	whereas	IN	IN	_	26	mark	_	_
16	stimulation	stimulation	NN	NN	_	26	nsubj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	anti	anti	JJ	JJ	_	19	amod	_	_
19	CD2	cd2	NN	NN	_	16	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	anti	anti	JJ	JJ	_	22	amod	_	_
22	CD28	cd28	NN	NN	_	19	conj	_	_
23	alone	alone	RB	RB	_	19	advmod	_	_
24	was	be	VBD	VBD	_	26	cop	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	effective	effective	JJ	JJ	_	4	advcl	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	5	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	genomic	genomic	JJ	JJ	_	1	dep	_	_
4	DMS	dms	NN	NN	_	5	compound	_	_
5	footprinting	footprinting	NN	NN	_	6	nsubj	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	upstream	upstream	RB	RB	_	6	advmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	major	major	JJ	JJ	_	13	amod	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	initiation	initiation	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	7	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	6	dobj	_	_
17	of	of	IN	IN	_	23	case	_	_
18	at	at	IN	IN	_	19	case	_	_
19	least	least	JJS	JJS	_	20	nmod:npmod	_	_
20	three	three	CD	CD	_	23	nummod	_	_
21	protein	protein	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	16	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	two	two	CD	CD	_	30	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	which	which	WDT	WDT	_	25	nmod	_	_
28	were	be	VBD	VBD	_	30	auxpass	_	_
29	constitutively	constitutively	RB	RB	_	30	advmod	_	_
30	occupied	occupy	VBN	VBN	_	23	acl:relcl	_	_
31	.	.	.	.	_	6	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	bind	bind	VBP	VBP	_	0	root	_	_
3	in	in	FW	FW	_	4	compound	_	_
4	vitro	vitro	FW	FW	_	2	advmod	_	_
5	respectively	respectively	RB	RB	_	2	advmod	_	_
6	ATF-1	atf-1	NN	NN	_	2	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NF-Y	nf-y	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	6	conj	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	third	third	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	occupied	occupy	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	quiescent	quiescent	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	stimulated	stimulate	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	anti	anti	JJ	JJ	_	15	amod	_	_
15	CD2	cd2	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	anti	anti	JJ	JJ	_	18	amod	_	_
18	CD28	cd28	NN	NN	_	15	conj	_	_
19	alone	alone	RB	RB	_	15	advmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mitogenic	mitogenic	JJ	JJ	_	3	amod	_	_
3	combination	combination	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	anti	anti	JJ	JJ	_	6	amod	_	_
6	CD2	cd2	NN	NN	_	3	nmod	_	_
7	+	+	CC	CC	_	6	cc	_	_
8	anti	anti	JJ	JJ	_	9	amod	_	_
9	CD28	cd28	NN	NN	_	6	conj	_	_
10	released	release	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	footprint	footprint	NN	NN	_	10	dobj	_	_
13	as	as	IN	IN	_	16	mark	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	committed	commit	VBN	VBN	_	10	advcl	_	_
17	to	to	TO	TO	_	18	case	_	_
18	proliferation	proliferation	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Consistent	consistent	JJ	JJ	_	12	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	theses	theses	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	12	nsubj	_	_
8	prepared	prepare	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	11	case	_	_
10	quiescent	quiescent	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	formed	form	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	specific	specific	JJ	JJ	_	15	amod	_	_
15	complex	complex	NN	NN	_	12	dobj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	element	element	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	12	punct	_	_
20	whereas	whereas	IN	IN	_	32	mark	_	_
21	extracts	extract	NNS	NNS	_	32	nsubj	_	_
22	prepared	prepare	VBN	VBN	_	21	acl	_	_
23	from	from	IN	IN	_	24	case	_	_
24	cells	cell	NNS	NNS	_	22	nmod	_	_
25	treated	treat	VBN	VBN	_	24	acl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	anti	anti	JJ	JJ	_	28	amod	_	_
28	CD2	cd2	NN	NN	_	25	nmod	_	_
29	+	+	CC	CC	_	28	cc	_	_
30	anti	anti	JJ	JJ	_	31	amod	_	_
31	CD28	cd28	NN	NN	_	28	conj	_	_
32	failed	fail	VBD	VBD	_	12	advcl	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	do	do	VB	VB	_	32	xcomp	_	_
35	so	so	RB	RB	_	34	advmod	_	_
36	after	after	IN	IN	_	38	mark	_	_
37	cells	cell	NNS	NNS	_	38	nsubj	_	_
38	entered	enter	VBD	VBD	_	32	advcl	_	_
39	a	a	DT	DT	_	41	det	_	_
40	proliferative	proliferative	JJ	JJ	_	41	amod	_	_
41	state	state	NN	NN	_	38	dobj	_	_
42	.	.	.	.	_	12	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	cloning	cloning	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	characterization	characterization	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	cDNA	cdna	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	CHEMR1	chemr1	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	encoding	encode	VBG	VBG	_	7	acl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	chemokine	chemokine	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	11	dobj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	homology	homology	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	C-C	c-c	NN	NN	_	23	compound	_	_
22	chemokine	chemokine	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	17	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	CCR-4	ccr-4	NN	NN	_	23	appos	_	_
26	.	.	.	.	_	2	punct	_	_

1	Chemokines	chemokine	NNS	NNS	_	2	nsubj	_	_
2	refer	refer	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	rapidly	rapidly	RB	RB	_	6	advmod	_	_
6	expanding	expand	VBG	VBG	_	7	amod	_	_
7	family	family	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	small	small	JJ	JJ	_	10	amod	_	_
10	cytokines	cytokine	NNS	NNS	_	7	nmod	_	_
11	whose	whose	WP$	WP$	_	13	nmod:poss	_	_
12	primary	primary	JJ	JJ	_	13	amod	_	_
13	function	function	NN	NN	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	recruitment	recruitment	NN	NN	_	7	acl:relcl	_	_
16	of	of	IN	IN	_	17	case	_	_
17	leukocytes	leukocyte	NNS	NNS	_	15	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	inflammatory	inflammatory	JJ	JJ	_	20	amod	_	_
20	sites	site	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	bind	bind	VB	VB	_	3	xcomp	_	_
6	to	to	TO	TO	_	9	case	_	_
7	seven-transmembrane-domain	seven-transmembrane-domain	NN	NN	_	9	compound	_	_
8	containing	contain	VBG	VBG	_	9	amod	_	_
9	receptors	receptor	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	15	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	CHEMR1	chemr1	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	resembling	resemble	VBG	VBG	_	3	acl	_	_
8	the	the	DT	DT	_	12	det	_	_
9	typical	typical	JJ	JJ	_	12	amod	_	_
10	G	g	NN	NN	_	12	compound	_	_
11	protein-coupled	protein-coupled	JJ	JJ	_	12	amod	_	_
12	receptor	receptor	NN	NN	_	7	xcomp	_	_
13	,	,	,	,	_	3	punct	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	isolated	isolate	VBN	VBN	_	0	root	_	_
16	from	from	IN	IN	_	24	case	_	_
17	a	a	DT	DT	_	24	det	_	_
18	mouse	mouse	NN	NN	_	24	compound	_	_
19	cytotoxic	cytotoxic	JJ	JJ	_	24	amod	_	_
20	T-lymphocyte	t-lymphocyte	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	CTL	ctl	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	library	library	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	mouse	mouse	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	nmod	_	_
8	suggests	suggest	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	expression	expression	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	8	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	variety	variety	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	including	include	VBG	VBG	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	macrophages	macrophage	NNS	NNS	_	22	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CHEMR1	chemr1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	8	nsubj	_	_
4	Scya3r2	scya3r2	NN	NN	_	3	dep	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	single-copy	single-copy	JJ	JJ	_	8	amod	_	_
8	gene	gene	NN	NN	_	0	root	_	_
9	whose	whose	WP$	WP$	_	12	nmod:poss	_	_
10	open	open	JJ	JJ	_	12	amod	_	_
11	reading	reading	NN	NN	_	12	compound	_	_
12	frame	frame	NN	NN	_	18	nsubj	_	_
13	may	may	MD	MD	_	18	aux	_	_
14	be	be	VB	VB	_	18	cop	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	single	single	JJ	JJ	_	18	amod	_	_
18	exon	exon	NN	NN	_	8	acl:relcl	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	maps	map	VBZ	VBZ	_	18	conj	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	distal	distal	JJ	JJ	_	24	amod	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	mouse	mouse	NN	NN	_	27	compound	_	_
27	Chr	chr	NN	NN	_	24	nmod	_	_
28	9	9	CD	CD	_	27	nummod	_	_
29	where	where	WRB	WRB	_	48	advmod	_	_
30	the	the	DT	DT	_	39	det	_	_
31	mouse	mouse	NN	NN	_	39	compound	_	_
32	macrophage	macrophage	NN	NN	_	39	compound	_	_
33	inflammatory	inflammatory	JJ	JJ	_	39	amod	_	_
34	protein-1alpha	protein-1alpha	NN	NN	_	39	compound	_	_
35	(	(	-LRB-	-LRB-	_	39	punct	_	_
36	MIP-1alpha	mip-1alpha	NN	NN	_	39	compound	_	_
37	)	)	-RRB-	-RRB-	_	39	punct	_	_
38	receptor	receptor	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	48	nsubj	_	_
40	Scya3r	scya3r	NN	NN	_	39	dep	_	_
41	and	and	CC	CC	_	39	cc	_	_
42	two	two	CD	CD	_	47	nummod	_	_
43	related	related	JJ	JJ	_	47	amod	_	_
44	C-C	c-c	NN	NN	_	47	compound	_	_
45	chemokine	chemokine	NN	NN	_	47	compound	_	_
46	receptor-like	receptor-like	JJ	JJ	_	47	amod	_	_
47	genes	gene	NNS	NNS	_	39	conj	_	_
48	reside	reside	VBP	VBP	_	24	acl:relcl	_	_
49	.	.	.	.	_	8	punct	_	_

1	Amino	amino	NN	NN	_	4	compound	_	_
2	acid	acid	NN	NN	_	4	compound	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	comparison	comparison	NN	NN	_	5	nsubj	_	_
5	shows	show	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	CHEMR1	chemr1	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	84	84	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	11	nmod:npmod	_	_
11	identical	identical	JJ	JJ	_	5	ccomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	CCR-4	ccr-4	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	indicating	indicate	VBG	VBG	_	11	xcomp	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	CHEMR1	chemr1	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	likely	likely	JJ	JJ	_	16	ccomp	_	_
21	to	to	TO	TO	_	25	mark	_	_
22	be	be	VB	VB	_	25	cop	_	_
23	a	a	DT	DT	_	25	det	_	_
24	mouse	mouse	NN	NN	_	25	compound	_	_
25	CCR-4	ccr-4	NN	NN	_	20	xcomp	_	_
26	.	.	.	.	_	5	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	10	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	125I-labeled	125i-labeled	JJ	JJ	_	6	amod	_	_
5	C-C	c-c	NN	NN	_	6	compound	_	_
6	chemokines	chemokine	NNS	NNS	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	mammalian	mammalian	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	indicated	indicate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	15	mark	_	_
12	CHEMR1	chemr1	NN	NN	_	15	nsubj	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	bind	bind	VB	VB	_	10	ccomp	_	_
16	MIP-1alpha	mip-1alpha	NN	NN	_	15	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	RANTES	rantes	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	or	or	CC	CC	_	16	cc	_	_
21	MIP-1beta	mip-1beta	NN	NN	_	16	conj	_	_
22	,	,	,	,	_	15	punct	_	_
23	whereas	whereas	IN	IN	_	25	mark	_	_
24	CCR-1	ccr-1	NN	NN	_	25	nsubj	_	_
25	binds	bind	VBZ	VBZ	_	15	advcl	_	_
26	MIP-1alpha	mip-1alpha	NN	NN	_	25	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	RANTES	rantes	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	result	result	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	different	different	JJ	JJ	_	0	root	_	_
5	from	from	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	reported	report	VBN	VBN	_	8	amod	_	_
8	properties	property	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	CCR-4	ccr-4	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	CHEMR1	chemr1	NN	NN	_	8	nsubj	_	_
5	may	may	MD	MD	_	8	aux	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	a	a	DT	DT	_	8	det	_	_
8	receptor	receptor	NN	NN	_	2	ccomp	_	_
9	for	for	IN	IN	_	12	case	_	_
10	unidentified	unidentified	JJ	JJ	_	12	amod	_	_
11	C-C	c-c	NN	NN	_	12	compound	_	_
12	chemokine	chemokine	NN	NN	_	8	nmod	_	_
13	or	or	CC	CC	_	8	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	low-affinity	low-affinity	JJ	JJ	_	16	amod	_	_
16	receptor	receptor	NN	NN	_	8	conj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	MIP-1alpha	mip-1alpha	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Biphasic	biphasic	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	triggering	triggering	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	HLA-DR	hla-dr	NN	NN	_	13	compound	_	_
13	antigens	antigen	NNS	NNS	_	10	nmod	_	_
14	expressed	express	VBN	VBN	_	13	acl	_	_
15	on	on	IN	IN	_	17	case	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	2	nmod	_	_
7	following	follow	VBG	VBG	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	triggering	triggering	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HLA-DR	hla-dr	NN	NN	_	12	compound	_	_
12	antigens	antigen	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	mAb	mab	NN	NN	_	15	compound	_	_
15	L243	l243	NN	NN	_	9	nmod	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	studied	study	VBN	VBN	_	0	root	_	_
19	at	at	IN	IN	_	21	case	_	_
20	various	various	JJ	JJ	_	21	amod	_	_
21	times	time	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	Raji	raji	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	18	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	strong	strong	JJ	JJ	_	8	amod	_	_
8	increase	increase	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	8	nmod	_	_
14	after	after	IN	IN	_	15	case	_	_
15	triggering	triggering	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	HLA-DR	hla-dr	NN	NN	_	18	compound	_	_
18	antigens	antigen	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	TNF-alpha-activity	tnf-alpha-activity	NN	NN	_	4	compound	_	_
3	neutralizing	neutralizing	NN	NN	_	4	compound	_	_
4	antibodies	antibody	NNS	NNS	_	1	dobj	_	_
5	,	,	,	,	_	1	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	authors	author	NNS	NNS	_	8	nsubj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	1	parataxis	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	upregulation	upregulation	NN	NN	_	16	nsubjpass	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	found	find	VBN	VBN	_	8	ccomp	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	depend	depend	VB	VB	_	16	xcomp	_	_
19	,	,	,	,	_	18	punct	_	_
20	at	at	IN	IN	_	23	case	_	_
21	later	later	JJR	JJR	_	23	amod	_	_
22	time	time	NN	NN	_	23	compound	_	_
23	point	point	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	on	on	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	autocrine	autocrine	JJ	JJ	_	28	amod	_	_
28	effect	effect	NN	NN	_	18	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	TNF-alpha	tnf-alpha	NN	NN	_	28	nmod	_	_
31	secreted	secrete	VBN	VBN	_	30	acl	_	_
32	following	follow	VBG	VBG	_	33	case	_	_
33	triggering	triggering	NN	NN	_	31	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	HLA-DR	hla-dr	NN	NN	_	36	compound	_	_
36	antigens	antigen	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	it	it	PRP	PRP	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	be	be	VB	VB	_	10	cop	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	10	nmod:npmod	_	_
10	independent	independent	JJ	JJ	_	6	xcomp	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	early	early	JJ	JJ	_	15	amod	_	_
14	time	time	NN	NN	_	15	compound	_	_
15	point	point	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	upregulation	upregulation	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	triggering	triggering	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	selected	select	VBN	VBN	_	17	amod	_	_
17	epitopes	epitope	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	HLA-DR	hla-dr	NN	NN	_	20	compound	_	_
20	antigens	antigen	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	mAb	mab	NN	NN	_	5	compound	_	_
5	L243	l243	NN	NN	_	23	nsubj	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	5	cc	_	_
8	the	the	DT	DT	_	10	det	_	_
9	staphylococcal	staphylococcal	JJ	JJ	_	10	amod	_	_
10	superantigens	superantigen	NNS	NNS	_	5	conj	_	_
11	,	,	,	,	_	10	punct	_	_
12	staphylococcal	staphylococcal	JJ	JJ	_	17	amod	_	_
13	exotoxin	exotoxin	NN	NN	_	17	compound	_	_
14	toxic	toxic	JJ	JJ	_	17	amod	_	_
15	shock	shock	NN	NN	_	17	compound	_	_
16	syndrome	syndrome	NN	NN	_	17	compound	_	_
17	toxin-I	toxin-i	NN	NN	_	10	conj	_	_
18	or	or	CC	CC	_	10	cc	_	_
19	staphylococcal	staphylococcal	JJ	JJ	_	21	amod	_	_
20	enterotoxin	enterotoxin	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	10	conj	_	_
22	,	,	,	,	_	5	punct	_	_
23	regulate	regulate	VBP	VBP	_	0	root	_	_
24	the	the	DT	DT	_	28	det	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	23	dobj	_	_
29	.	.	.	.	_	23	punct	_	_

1	Anti-Ehrlichia	anti-ehrlichia	FW	FW	_	3	compound	_	_
2	chaffeensis	chaffeensis	FW	FW	_	3	compound	_	_
3	antibody	antibody	NN	NN	_	8	nsubj	_	_
4	complexed	complex	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	E.	e.	FW	FW	_	7	compound	_	_
7	chaffeensis	chaffeensis	FW	FW	_	4	nmod	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	potent	potent	JJ	JJ	_	13	amod	_	_
10	proinflammatory	proinflammatory	JJ	JJ	_	12	amod	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
17	through	through	IN	IN	_	19	case	_	_
18	sustained	sustained	JJ	JJ	_	19	amod	_	_
19	reduction	reduction	NN	NN	_	8	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IkappaB-alpha	ikappab-alpha	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	activation	activation	NN	NN	_	19	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Ehrlichia	ehrlichia	FW	FW	_	2	compound	_	_
2	chaffeensis	chaffeensis	FW	FW	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	an	a	DT	DT	_	7	det	_	_
5	obligatory	obligatory	JJ	JJ	_	7	amod	_	_
6	intracellular	intracellular	JJ	JJ	_	5	dep	_	_
7	bacterium	bacterium	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	infects	infect	VBZ	VBZ	_	7	acl:relcl	_	_
10	monocytes	monocyte	NNS	NNS	_	9	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	macrophages	macrophage	NNS	NNS	_	10	conj	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	the	the	DT	DT	_	17	det	_	_
16	etiologic	etiologic	JJ	JJ	_	17	amod	_	_
17	agent	agent	NN	NN	_	7	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	ehrlichiosis	ehrlichiosis	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	United	United	NNP	NNP	_	24	compound	_	_
24	States	States	NNPS	NNPS	_	17	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	exposure	exposure	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	E.	e.	FW	FW	_	13	compound	_	_
13	chaffeensis	chaffeensis	FW	FW	_	7	nmod	_	_
14	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	interleukin-1beta	interleukin-1beta	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IL-1beta	il-1beta	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	18	punct	_	_
23	IL-8	il-8	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	18	punct	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	IL-10	il-10	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	18	conj	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vitro	vitro	FW	FW	_	16	advmod	_	_
30	but	but	CC	CC	_	31	cc	_	_
31	not	not	RB	RB	_	16	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	expression	expression	NN	NN	_	16	conj	_	_
34	of	of	IN	IN	_	38	case	_	_
35	tumor	tumor	NN	NN	_	38	compound	_	_
36	necrosis	necrosis	NN	NN	_	38	compound	_	_
37	factor	factor	NN	NN	_	38	compound	_	_
38	alpha	alpha	NN	NN	_	33	nmod	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	TNF-alpha	tnf-alpha	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	IL-6	il-6	NN	NN	_	38	conj	_	_
44	mRNAs	mrna	NNS	NNS	_	38	dep	_	_
45	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	26	nmod	_	_
4	,	,	,	,	_	26	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	26	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	anti-E.	anti-e.	FW	FW	_	10	compound	_	_
9	chaffeensis	chaffeensis	FW	FW	_	10	compound	_	_
10	antibody	antibody	NN	NN	_	6	nmod	_	_
11	complexed	complex	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	E.	e.	FW	FW	_	14	compound	_	_
14	chaffeensis	chaffeensis	FW	FW	_	11	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	6	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	major	major	JJ	JJ	_	21	amod	_	_
20	proinflammatory	proinflammatory	JJ	JJ	_	21	amod	_	_
21	cytokines	cytokine	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	examined	examine	VBN	VBN	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	monocytic	monocytic	JJ	JJ	_	5	amod	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	line	line	NN	NN	_	5	compound	_	_
5	THP-1	thp-1	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	treated	treat	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	E.	e.	FW	FW	_	10	compound	_	_
10	chaffeensis	chaffeensis	FW	FW	_	7	nmod	_	_
11	which	which	WDT	WDT	_	14	nsubj	_	_
12	had	have	VBD	VBD	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	cop	_	_
14	preincubated	preincubated	JJ	JJ	_	10	acl:relcl	_	_
15	with	with	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	anti-E.	anti-e.	FW	FW	_	19	compound	_	_
18	chaffeensis	chaffeensis	FW	FW	_	19	compound	_	_
19	serum	serum	NN	NN	_	14	nmod	_	_
20	for	for	IN	IN	_	22	case	_	_
21	2	2	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	14	nmod	_	_
23	,	,	,	,	_	7	punct	_	_
24	and	and	CC	CC	_	7	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	levels	level	NNS	NNS	_	31	nsubjpass	_	_
27	of	of	IN	IN	_	29	case	_	_
28	cytokine	cytokine	NN	NN	_	29	compound	_	_
29	mRNAs	mrna	NNS	NNS	_	26	nmod	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	evaluated	evaluate	VBN	VBN	_	7	conj	_	_
32	by	by	IN	IN	_	35	case	_	_
33	competitive	competitive	JJ	JJ	_	35	amod	_	_
34	reverse	reverse	JJ	JJ	_	35	amod	_	_
35	transcription-PCR	transcription-pcr	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	Anti-E.	anti-e.	FW	FW	_	3	compound	_	_
2	chaffeensis	chaffeensis	FW	FW	_	3	compound	_	_
3	antibody	antibody	NN	NN	_	9	nsubj	_	_
4	complexed	complex	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	E.	e.	FW	FW	_	7	compound	_	_
7	chaffeensis	chaffeensis	FW	FW	_	4	nmod	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	enhanced	enhance	VBD	VBD	_	0	root	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-1beta	il-1beta	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	THP-1	thp-1	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-6	il-6	NN	NN	_	4	conj	_	_
7	mRNAs	mrna	NNS	NNS	_	4	dep	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	induced	induce	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	17	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	secreted	secrete	VBN	VBN	_	5	amod	_	_
5	IL-1beta	il-1beta	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	IL-6	il-6	NN	NN	_	5	conj	_	_
11	during	during	IN	IN	_	13	case	_	_
12	24	24	CD	CD	_	13	nummod	_	_
13	h	h	NN	NN	_	2	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	13	nmod	_	_
16	were	be	VBD	VBD	_	17	cop	_	_
17	comparable	comparable	JJ	JJ	_	0	root	_	_
18	to	to	TO	TO	_	19	case	_	_
19	those	those	DT	DT	_	17	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	Escherichia	escherichia	FW	FW	_	24	compound	_	_
23	coli	coli	FW	FW	_	24	compound	_	_
24	lipopolysaccharide	lipopolysaccharide	NN	NN	_	20	nmod	_	_
25	at	at	IN	IN	_	27	case	_	_
26	1	1	CD	CD	_	27	nummod	_	_
27	microg/ml	microg/ml	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	Fab	fab	NN	NN	_	2	compound	_	_
2	fragment	fragment	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	anti-E.	anti-e.	FW	FW	_	7	compound	_	_
5	chaffeensis	chaffeensis	FW	FW	_	7	compound	_	_
6	immunoglobulin	immunoglobulin	NN	NN	_	7	compound	_	_
7	G	g	NN	NN	_	2	nmod	_	_
8	complexed	complex	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	11	case	_	_
10	E.	e.	FW	FW	_	11	compound	_	_
11	chaffeensis	chaffeensis	FW	FW	_	8	nmod	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	induce	induce	VB	VB	_	0	root	_	_
15	any	any	DT	DT	_	14	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	these	these	DT	DT	_	19	det	_	_
18	three	three	CD	CD	_	19	nummod	_	_
19	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	indicating	indicate	VBG	VBG	_	14	advcl	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	ehrlichial	ehrlichial	JJ	JJ	_	24	amod	_	_
24	binding	binding	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	required	require	VBN	VBN	_	21	ccomp	_	_
27	for	for	IN	IN	_	30	case	_	_
28	IL-1beta	il-1beta	NN	NN	_	29	compound	_	_
29	mRNA	mrna	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	26	cc	_	_
32	that	that	IN	IN	_	44	mark	_	_
33	binding	binding	NN	NN	_	44	nsubjpass	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	immune	immune	JJ	JJ	_	37	amod	_	_
37	complex	complex	NN	NN	_	33	nmod	_	_
38	to	to	TO	TO	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	Fc	fc	NN	NN	_	42	compound	_	_
41	gamma	gamma	NN	NN	_	42	compound	_	_
42	receptor	receptor	NN	NN	_	33	nmod	_	_
43	is	be	VBZ	VBZ	_	44	auxpass	_	_
44	required	require	VBN	VBN	_	26	conj	_	_
45	for	for	IN	IN	_	46	case	_	_
46	TNF-alpha	tnf-alpha	NN	NN	_	44	nmod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	IL-6	il-6	NN	NN	_	49	compound	_	_
49	mRNA	mrna	NN	NN	_	46	conj	_	_
50	expression	expression	NN	NN	_	46	dep	_	_
51	and	and	CC	CC	_	46	cc	_	_
52	enhanced	enhance	VBD	VBD	_	55	amod	_	_
53	IL-1beta	il-1beta	NN	NN	_	54	compound	_	_
54	mRNA	mrna	NN	NN	_	55	compound	_	_
55	expression	expression	NN	NN	_	46	conj	_	_
56	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	prolonged	prolonged	JJ	JJ	_	4	amod	_	_
4	degradation	degradation	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IkappaB-alpha	ikappab-alpha	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	activation	activation	NN	NN	_	4	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	THP-1	thp-1	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	exposed	expose	VBN	VBN	_	15	acl	_	_
17	to	to	TO	TO	_	20	case	_	_
18	anti-E.	anti-e.	FW	FW	_	20	compound	_	_
19	chaffeensis	chaffeensis	FW	FW	_	20	compound	_	_
20	serum	serum	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	E.	e.	FW	FW	_	23	compound	_	_
23	chaffeensis	chaffeensis	FW	FW	_	20	conj	_	_
24	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	implies	imply	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	development	development	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	anti-E.	anti-e.	FW	FW	_	9	compound	_	_
8	chaffeensis	chaffeensis	FW	FW	_	9	compound	_	_
9	antibody	antibody	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	5	nmod	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	result	result	VB	VB	_	3	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	production	production	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	major	major	JJ	JJ	_	20	amod	_	_
19	proinflammatory	proinflammatory	JJ	JJ	_	20	amod	_	_
20	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	which	which	WDT	WDT	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	play	play	VB	VB	_	13	ccomp	_	_
25	an	a	DT	DT	_	27	det	_	_
26	important	important	JJ	JJ	_	27	amod	_	_
27	role	role	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	pathophysiology	pathophysiology	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	ehrlichiosis	ehrlichiosis	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	30	cc	_	_
34	immune	immune	JJ	JJ	_	35	amod	_	_
35	responses	response	NNS	NNS	_	30	conj	_	_
36	to	to	TO	TO	_	37	case	_	_
37	it	it	PRP	PRP	_	35	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	S-allyl	s-allyl	JJ	JJ	_	2	amod	_	_
2	cysteine	cysteine	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	activation	activation	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Reactive	reactive	JJ	JJ	_	3	amod	_	_
2	oxygen	oxygen	NN	NN	_	3	compound	_	_
3	species	species	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	involved	involve	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	signal	signal	NN	NN	_	9	compound	_	_
8	transduction	transduction	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	5	nmod	_	_
10	leading	lead	VBG	VBG	_	9	acl	_	_
11	to	to	TO	TO	_	20	case	_	_
12	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	activation	activation	NN	NN	_	10	nmod	_	_
21	which	which	WDT	WDT	_	24	nsubjpass	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	implicated	implicate	VBN	VBN	_	20	acl:relcl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	regulation	regulation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	transcription	transcription	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	garlic	garlic	JJ	JJ	_	7	amod	_	_
7	compound	compound	NN	NN	_	15	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	S-allyl	s-allyl	JJ	JJ	_	10	amod	_	_
10	cysteine	cysteine	NN	NN	_	7	appos	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SAC	sac	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	7	punct	_	_
15	protects	protect	VBZ	VBZ	_	3	ccomp	_	_
16	bovine	bovine	JJ	JJ	_	20	amod	_	_
17	pulmonary	pulmonary	JJ	JJ	_	20	amod	_	_
18	artery	artery	NN	NN	_	20	compound	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	15	dobj	_	_
21	from	from	IN	IN	_	23	case	_	_
22	oxidant	oxidant	JJ	JJ	_	23	amod	_	_
23	injury	injury	NN	NN	_	15	nmod	_	_
24	induced	induce	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	27	case	_	_
26	hydrogen	hydrogen	NN	NN	_	27	compound	_	_
27	peroxide	peroxide	NN	NN	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	H2O2	h2o2	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	determined	determine	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	SAC	sac	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	13	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	7	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	Jurkat	jurkat	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	induced	induce	VBN	VBN	_	13	acl	_	_
23	by	by	IN	IN	_	27	case	_	_
24	tumor	tumor	NN	NN	_	27	compound	_	_
25	necrosis	necrosis	NN	NN	_	27	compound	_	_
26	factor	factor	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	TNF-alpha	tnf-alpha	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	H2O2	h2o2	NN	NN	_	27	conj	_	_
33	.	.	.	.	_	5	punct	_	_

1	Activated	activate	VBN	VBN	_	3	amod	_	_
2	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	8	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	extracts	extract	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	measured	measure	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	electrophoretic	electrophoretic	JJ	JJ	_	14	amod	_	_
12	mobility	mobility	NN	NN	_	14	compound	_	_
13	shift	shift	NN	NN	_	14	compound	_	_
14	assay	assay	NN	NN	_	8	nmod	_	_
15	using	use	VBG	VBG	_	14	acl	_	_
16	32P-labeled	32p-labeled	JJ	JJ	_	17	amod	_	_
17	probe	probe	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	8	punct	_	_

1	SAC	sac	NN	NN	_	3	nsubj	_	_
2	consistently	consistently	RB	RB	_	3	advmod	_	_
3	exhibited	exhibit	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	dose-dependent	dose-dependent	JJ	JJ	_	6	amod	_	_
6	inhibition	inhibition	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	H2O2	h2o2	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Supershift	supershift	NN	NN	_	9	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	specific	specific	JJ	JJ	_	4	amod	_	_
4	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	subunits	subunit	NNS	NNS	_	1	nmod	_	_
9	confirmed	confirm	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	15	mark	_	_
11	the	the	DT	DT	_	14	det	_	_
12	inducible	inducible	JJ	JJ	_	14	amod	_	_
13	retarded	retard	VBN	VBN	_	14	amod	_	_
14	bands	band	NNS	NNS	_	15	nsubj	_	_
15	observed	observe	VBN	VBN	_	9	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	EMSA	emsa	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	p65-p50	p65-p50	NN	NN	_	21	compound	_	_
21	heterodimer	heterodimer	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B/Rel	b/rel	NN	NN	_	26	compound	_	_
26	protein	protein	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	SAC	sac	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	act	act	VB	VB	_	3	ccomp	_	_
8	via	via	IN	IN	_	10	case	_	_
9	antioxidant	antioxidant	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	block	block	VB	VB	_	7	xcomp	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	Jurkat	jurkat	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Effect	effect	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	adenovirus	adenovirus	NN	NN	_	1	nmod	_	_
4	2	2	CD	CD	_	3	nummod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	cellular	cellular	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	blood-derived	blood-derived	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	macrophages	macrophage	NNS	NNS	_	11	conj	_	_
14	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	adenovirus	adenovirus	NN	NN	_	12	compound	_	_
8	2	2	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Ad2	ad2	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	infection	infection	NN	NN	_	5	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	monocyte-derived	monocyte-derived	JJ	JJ	_	18	amod	_	_
18	macrophages	macrophage	NNS	NNS	_	15	conj	_	_
19	with	with	IN	IN	_	20	case	_	_
20	regard	regard	NN	NN	_	3	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	expression	expression	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	IL-1	il-1	NN	NN	_	27	compound	_	_
27	beta	beta	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	virus	virus	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	bound	bind	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	surface	surface	NN	NN	_	7	nmod	_	_
11	without	without	IN	IN	_	13	mark	_	_
12	being	be	VBG	VBG	_	13	auxpass	_	_
13	internalized	internalize	VBN	VBN	_	7	advcl	_	_
14	.	.	.	.	_	7	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	Ad2	ad2	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	internalized	internalize	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	virus	virus	NN	NN	_	3	compound	_	_
3	replication	replication	NN	NN	_	13	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	transcription	transcription	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	Ad2	ad2	NN	NN	_	11	compound	_	_
10	early	early	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	6	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	either	either	DT	DT	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Ad2	ad2	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	transient	transient	JJ	JJ	_	5	amod	_	_
5	increase	increase	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	5	nmod	_	_
10	for	for	IN	IN	_	11	case	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-1	il-1	NN	NN	_	14	compound	_	_
14	beta	beta	NN	NN	_	11	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	both	both	CC	CC	_	17	dep	_	_
17	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	in	in	IN	IN	_	20	case	_	_
20	macrophages	macrophage	NNS	NNS	_	17	conj	_	_
21	,	,	,	,	_	3	punct	_	_
22	although	although	IN	IN	_	30	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	kinetics	kinetics	NNS	NNS	_	30	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	transcription	transcription	NN	NN	_	24	nmod	_	_
28	was	be	VBD	VBD	_	30	cop	_	_
29	slightly	slightly	RB	RB	_	30	advmod	_	_
30	different	different	JJ	JJ	_	3	advcl	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	production	production	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	DT	DT	_	5	dep	_	_
5	cytokines	cytokine	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	measured	measure	VBN	VBN	_	2	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	ELISA	elisa	NN	NN	_	10	compound	_	_
10	tests	test	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	enhanced	enhance	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	macrophages	macrophage	NNS	NNS	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	slight	slight	JJ	JJ	_	6	amod	_	_
6	enhancement	enhancement	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	seen	see	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	whereas	whereas	IN	IN	_	18	mark	_	_
14	IL-1	il-1	NN	NN	_	15	compound	_	_
15	beta	beta	NN	NN	_	18	nsubjpass	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	detected	detect	VBN	VBN	_	11	advcl	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	9	nsubjpass	_	_
7	might	might	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	activated	activate	VBN	VBN	_	3	ccomp	_	_
10	by	by	IN	IN	_	13	case	_	_
11	Ad2	ad2	NN	NN	_	13	compound	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	infection	infection	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	nonpermissive	nonpermissive	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	where	where	WRB	WRB	_	24	advmod	_	_
18	no	no	DT	DT	_	21	neg	_	_
19	viral	viral	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	products	product	NNS	NNS	_	24	nsubjpass	_	_
22	could	could	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	detected	detect	VBN	VBN	_	16	acl:relcl	_	_
25	.	.	.	.	_	3	punct	_	_

1	AP-1	ap-1	NN	NN	_	9	nsubj	_	_
2	derived	derive	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	5	case	_	_
4	mature	mature	JJ	JJ	_	5	amod	_	_
5	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	astrocytes	astrocyte	NNS	NNS	_	5	conj	_	_
8	preferentially	preferentially	RB	RB	_	9	advmod	_	_
9	interacts	interact	VBZ	VBZ	_	0	root	_	_
10	with	with	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	HTLV-I	htlv-i	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	central	central	JJ	JJ	_	13	amod	_	_
15	21	21	CD	CD	_	17	nummod	_	_
16	bp	bp	NN	NN	_	17	compound	_	_
17	repeat	repeat	NN	NN	_	13	dep	_	_
18	.	.	.	.	_	9	punct	_	_

1	Characterization	characterization	NN	NN	_	27	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	cellular	cellular	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	1	nmod	_	_
7	interacting	interact	VBG	VBG	_	6	acl	_	_
8	with	with	IN	IN	_	22	case	_	_
9	the	the	DT	DT	_	22	det	_	_
10	human	human	JJ	JJ	_	22	amod	_	_
11	T	t	NN	NN	_	22	compound	_	_
12	cell	cell	NN	NN	_	22	compound	_	_
13	lymphotropic	lymphotropic	JJ	JJ	_	22	amod	_	_
14	virus	virus	NN	NN	_	22	compound	_	_
15	type	type	NN	NN	_	22	compound	_	_
16	I	i	CD	CD	_	22	nummod	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	HTLV-I	htlv-i	NN	NN	_	22	compound	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	long	long	JJ	JJ	_	22	amod	_	_
21	terminal	terminal	JJ	JJ	_	22	amod	_	_
22	repeat	repeat	NN	NN	_	7	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	LTR	ltr	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	essential	essential	JJ	JJ	_	0	root	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	dissecting	dissect	VBG	VBG	_	27	advcl	_	_
30	the	the	DT	DT	_	31	det	_	_
31	mechanisms	mechanism	NNS	NNS	_	29	dobj	_	_
32	involved	involve	VBN	VBN	_	31	acl	_	_
33	in	in	IN	IN	_	35	case	_	_
34	viral	viral	JJ	JJ	_	35	amod	_	_
35	transcription	transcription	NN	NN	_	32	nmod	_	_
36	that	that	WDT	WDT	_	39	nsubj	_	_
37	may	may	MD	MD	_	39	aux	_	_
38	be	be	VB	VB	_	39	cop	_	_
39	pertinent	pertinent	JJ	JJ	_	31	acl:relcl	_	_
40	to	to	TO	TO	_	42	case	_	_
41	the	the	DT	DT	_	42	dep	_	_
42	oncogenic	oncogenic	JJ	JJ	_	39	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	neuropathogenic	neuropathogenic	JJ	JJ	_	42	conj	_	_
45	processes	process	NNS	NNS	_	42	dep	_	_
46	associated	associate	VBN	VBN	_	42	acl	_	_
47	with	with	IN	IN	_	49	case	_	_
48	HTLV-I	htlv-i	NN	NN	_	49	compound	_	_
49	infection	infection	NN	NN	_	46	nmod	_	_
50	in	in	IN	IN	_	53	case	_	_
51	both	both	CC	CC	_	53	cc:preconj	_	_
52	the	the	DT	DT	_	53	dep	_	_
53	immune	immune	JJ	JJ	_	49	nmod	_	_
54	and	and	CC	CC	_	53	cc	_	_
55	nervous	nervous	JJ	JJ	_	53	conj	_	_
56	systems	system	NNS	NNS	_	53	dep	_	_
57	.	.	.	.	_	27	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	3	amod	_	_
2	mobility	mobility	NN	NN	_	3	compound	_	_
3	shift	shift	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EMS	ems	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	analyses	analysis	NNS	NNS	_	39	nsubj	_	_
8	utilizing	utilize	VBG	VBG	_	7	acl	_	_
9	oligonucleotides	oligonucleotide	NNS	NNS	_	8	dobj	_	_
10	homologous	homologous	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	each	each	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	21	21	CD	CD	_	18	nummod	_	_
16	bp	bp	NN	NN	_	18	compound	_	_
17	repeat	repeat	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	12	nmod	_	_
19	reacted	react	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	22	case	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	extracts	extract	NNS	NNS	_	19	nmod	_	_
23	derived	derive	VBN	VBN	_	22	acl	_	_
24	from	from	IN	IN	_	26	case	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	lymphocytic	lymphocytic	JJ	JJ	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	monocytic	monocytic	JJ	JJ	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	neuronal	neuronal	JJ	JJ	_	28	conj	_	_
33	,	,	,	,	_	28	punct	_	_
34	and	and	CC	CC	_	28	cc	_	_
35	glial	glial	JJ	JJ	_	28	conj	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	origin	origin	NN	NN	_	28	dep	_	_
38	have	have	VBP	VBP	_	39	aux	_	_
39	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
40	differential	differential	JJ	JJ	_	41	amod	_	_
41	binding	binding	NN	NN	_	39	dobj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	cellular	cellular	JJ	JJ	_	44	amod	_	_
44	factors	factor	NNS	NNS	_	41	nmod	_	_
45	to	to	TO	TO	_	50	case	_	_
46	the	the	DT	DT	_	50	det	_	_
47	three	three	CD	CD	_	50	nummod	_	_
48	21	21	CD	CD	_	50	nummod	_	_
49	bp	bp	NN	NN	_	50	compound	_	_
50	repeats	repeat	NNS	NNS	_	41	nmod	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	1-4	1-4	CD	CD	_	50	appos	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	.	.	.	.	_	39	punct	_	_

1	ATF/CREB	atf/creb	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Sp	sp	NN	NN	_	5	compound	_	_
4	family	family	NN	NN	_	5	compound	_	_
5	members	member	NNS	NNS	_	1	conj	_	_
6	interacted	interact	VBD	VBD	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	21	21	CD	CD	_	11	nummod	_	_
10	bp	bp	NN	NN	_	11	compound	_	_
11	repeats	repeat	NNS	NNS	_	6	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	form	form	VB	VB	_	6	xcomp	_	_
14	DNA-protein	dna-protein	JJ	JJ	_	15	amod	_	_
15	complexes	complex	NNS	NNS	_	13	dobj	_	_
16	common	common	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	all	all	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	types	type	NNS	NNS	_	16	nmod	_	_
21	examined	examine	VBN	VBN	_	20	acl	_	_
22	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	unique	unique	JJ	JJ	_	6	amod	_	_
5	DNA-protein	dna-protein	JJ	JJ	_	6	amod	_	_
6	complex	complex	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	when	when	WRB	WRB	_	17	advmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	promoter	promoter	NN	NN	_	17	nsubjpass	_	_
12	central	central	JJ	JJ	_	11	amod	_	_
13	21	21	CD	CD	_	15	nummod	_	_
14	bp	bp	NN	NN	_	15	compound	_	_
15	repeat	repeat	NN	NN	_	11	dep	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	reacted	react	VBN	VBN	_	8	advcl	_	_
18	with	with	IN	IN	_	20	case	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	extracts	extract	NNS	NNS	_	17	nmod	_	_
21	derived	derive	VBN	VBN	_	20	acl	_	_
22	from	from	IN	IN	_	29	case	_	_
23	either	either	CC	CC	_	29	cc:preconj	_	_
24	the	the	DT	DT	_	29	det	_	_
25	U-373	u-373	NN	NN	_	29	compound	_	_
26	MG	mg	NN	NN	_	29	compound	_	_
27	glioblastoma	glioblastoma	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	21	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	36	det	_	_
32	THP-1	thp-1	NN	NN	_	36	compound	_	_
33	mature	mature	JJ	JJ	_	36	amod	_	_
34	monocytic	monocytic	JJ	JJ	_	36	amod	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	line	line	NN	NN	_	29	conj	_	_
37	.	.	.	.	_	8	punct	_	_

1	Based	base	VBN	VBN	_	3	case	_	_
2	on	on	IN	IN	_	3	case	_	_
3	nucleotide	nucleotide	NN	NN	_	10	advcl	_	_
4	sequence	sequence	NN	NN	_	5	compound	_	_
5	requirements	requirement	NNS	NNS	_	3	dep	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	immunoreactivity	immunoreactivity	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	16	mark	_	_
12	this	this	DT	DT	_	14	det	_	_
13	DNA-protein	dna-protein	JJ	JJ	_	14	amod	_	_
14	complex	complex	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	comprised	comprise	VBN	VBN	_	10	ccomp	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	AP-1	ap-1	NN	NN	_	20	compound	_	_
20	components	component	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	Fos	fos	NN	NN	_	20	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Jun	jun	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	10	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	acute	acute	JJ	JJ	_	5	amod	_	_
3	myeloid	myeloid	JJ	JJ	_	5	amod	_	_
4	leukemia	leukemia	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	9	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	AML1	aml1	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	regulates	regulate	VBZ	VBZ	_	0	root	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	hemopoietic	hemopoietic	JJ	JJ	_	16	amod	_	_
14	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	differentiation	differentiation	NN	NN	_	11	conj	_	_
17	antagonistically	antagonistically	RB	RB	_	9	advmod	_	_
18	by	by	IN	IN	_	22	case	_	_
19	two	two	CD	CD	_	22	nummod	_	_
20	alternative	alternative	JJ	JJ	_	21	amod	_	_
21	spliced	spliced	JJ	JJ	_	22	amod	_	_
22	forms	form	NNS	NNS	_	9	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	AML1	aml1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	8	nsubjpass	_	_
4	on	on	IN	IN	_	5	case	_	_
5	chromosome	chromosome	NN	NN	_	3	nmod	_	_
6	21	21	CD	CD	_	5	nummod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	disrupted	disrupt	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	(8;21)(q22;q22)	(8;21)(q22;q22)	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	(3;21)(q26;q22)	(3;21)(q26;q22)	NN	NN	_	11	conj	_	_
14	translocations	translocation	NNS	NNS	_	11	dep	_	_
15	associated	associate	VBN	VBN	_	11	acl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	myelogenous	myelogenous	JJ	JJ	_	18	amod	_	_
18	leukemias	leukemia	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	encodes	encode	VBZ	VBZ	_	8	conj	_	_
21	a	a	DT	DT	_	23	det	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	8	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	AML1	aml1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	representative	representative	JJ	JJ	_	7	amod	_	_
7	forms	form	NNS	NNS	_	16	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	proteins	protein	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	AML1a	aml1a	NN	NN	_	7	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	AML1b	aml1b	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	produced	produce	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	alternative	alternative	JJ	JJ	_	20	amod	_	_
20	splicing	splicing	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	forms	form	NNS	NNS	_	3	nsubj	_	_
3	have	have	VBP	VBP	_	0	root	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	domain	domain	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	3	punct	_	_
7	but	but	CC	CC	_	3	cc	_	_
8	AML1a	aml1a	NN	NN	_	9	nsubj	_	_
9	lacks	lack	VBZ	VBZ	_	3	conj	_	_
10	a	a	DT	DT	_	14	det	_	_
11	putative	putative	JJ	JJ	_	14	amod	_	_
12	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
13	activation	activation	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	9	dobj	_	_
15	which	which	WDT	WDT	_	17	dobj	_	_
16	AML1b	aml1b	NN	NN	_	17	nsubj	_	_
17	has	have	VBZ	VBZ	_	14	acl:relcl	_	_
18	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	AML1a	aml1a	NN	NN	_	18	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	solely	solely	RB	RB	_	9	advmod	_	_
9	has	have	VBZ	VBZ	_	5	acl:relcl	_	_
10	no	no	DT	DT	_	11	neg	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	as	as	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	regulator	regulator	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	dominantly	dominantly	RB	RB	_	18	advmod	_	_
18	suppresses	suppress	VBZ	VBZ	_	3	ccomp	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	18	dobj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	AML1b	aml1b	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	18	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	that	that	IN	IN	_	27	mark	_	_
26	AML1a	aml1a	NN	NN	_	27	nsubj	_	_
27	exhibits	exhibit	VBZ	VBZ	_	18	conj	_	_
28	the	the	DT	DT	_	30	det	_	_
29	higher	higher	JJR	JJR	_	30	amod	_	_
30	affinity	affinity	NN	NN	_	27	dobj	_	_
31	for	for	IN	IN	_	32	case	_	_
32	DNA-binding	dna-binding	JJ	JJ	_	30	nmod	_	_
33	than	than	IN	IN	_	34	mark	_	_
34	AML1b	aml1b	NN	NN	_	30	dep	_	_
35	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	a	a	DT	DT	_	5	det	_	_
3	dominant	dominant	JJ	JJ	_	5	amod	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	form	form	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	AML1	aml1	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	AML1a	aml1a	NN	NN	_	5	appos	_	_
10	,	,	,	,	_	5	punct	_	_
11	totally	totally	RB	RB	_	12	advmod	_	_
12	suppressed	suppress	VBD	VBD	_	0	root	_	_
13	granulocytic	granulocytic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	12	dobj	_	_
15	otherwise	otherwise	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	14	acl	_	_
17	by	by	IN	IN	_	20	case	_	_
18	granulocyte	granulocyte	NN	NN	_	20	compound	_	_
19	colony-stimulating	colony-stimulating	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	16	nmod	_	_
21	when	when	WRB	WRB	_	24	advmod	_	_
22	AML1a	aml1a	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	overexpressed	overexpress	VBN	VBN	_	12	advcl	_	_
25	in	in	IN	IN	_	29	case	_	_
26	32Dc13	32dc13	NN	NN	_	29	compound	_	_
27	murine	murine	JJ	JJ	_	29	amod	_	_
28	myeloid	myeloid	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Such	such	JJ	JJ	_	3	amod	_	_
2	differentiation	differentiation	NN	NN	_	3	compound	_	_
3	block	block	NN	NN	_	7	nsubjpass	_	_
4	by	by	IN	IN	_	5	case	_	_
5	AML1a	aml1a	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	canceled	cancel	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	concomitant	concomitant	JJ	JJ	_	11	amod	_	_
11	overexpression	overexpression	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	AML1b	aml1b	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	a	a	DT	DT	_	9	det	_	_
7	transcriptionally	transcriptionally	RB	RB	_	8	advmod	_	_
8	active	active	JJ	JJ	_	9	advmod	_	_
9	form	form	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	AML1	aml1	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	essential	essential	JJ	JJ	_	4	ccomp	_	_
14	for	for	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	differentiation	differentiation	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	observed	observe	VBD	VBD	_	0	root	_	_
6	an	a	DT	DT	_	9	det	_	_
7	altered	altered	JJ	JJ	_	9	amod	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	level	level	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	AML1	aml1	NN	NN	_	9	nmod	_	_
12	along	along	IN	IN	_	16	case	_	_
13	with	with	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	5	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	several	several	JJ	JJ	_	21	amod	_	_
19	hemopoietic	hemopoietic	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	cases	case	NNS	NNS	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	at	at	IN	IN	_	15	advmod	_	_
6	least	least	JJS	JJS	_	5	mwe	_	_
7	,	,	,	,	_	15	punct	_	_
8	the	the	DT	DT	_	11	det	_	_
9	AML1	aml1	NN	NN	_	11	compound	_	_
10	expression	expression	NN	NN	_	11	compound	_	_
11	level	level	NN	NN	_	15	nsubj	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	potential	potential	JJ	JJ	_	15	amod	_	_
15	regulator	regulator	NN	NN	_	0	root	_	_
16	for	for	IN	IN	_	19	case	_	_
17	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Of	of	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	GATA-binding	gata-binding	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	GATA-4	gata-4	NN	NN	_	9	nsubj	_	_
8	selectively	selectively	RB	RB	_	9	advmod	_	_
9	regulates	regulate	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	14	det	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	IL-5	il-5	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	9	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	IL-5	il-5	NN	NN	_	18	compound	_	_
17	producing	producing	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	9	nmod	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	express	express	VBP	VBP	_	18	acl:relcl	_	_
21	multiple	multiple	JJ	JJ	_	23	amod	_	_
22	GATA-binding	gata-binding	JJ	JJ	_	23	amod	_	_
23	proteins	protein	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	9	punct	_	_

1	Interleukin-5	interleukin-5	NN	NN	_	6	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-5	il-5	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	produced	produce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	known	know	VBN	VBN	_	6	conj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	support	support	VB	VB	_	11	xcomp	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	growth	growth	NN	NN	_	13	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	eosinophilic	eosinophilic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	16	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	progenitor	progenitor	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	ATL-16T	atl-16t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	1	dobj	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	3	acl:relcl	_	_
6	IL-5	il-5	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	1	punct	_	_
9	we	we	PRP	PRP	_	11	nsubj	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	identified	identify	VBN	VBN	_	1	parataxis	_	_
12	a	a	DT	DT	_	13	det	_	_
13	region	region	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	within	within	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	IL-5	il-5	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	13	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	regulates	regulate	VBZ	VBZ	_	13	acl:relcl	_	_
24	IL-5	il-5	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cis-acting	cis-acting	JJ	JJ	_	3	amod	_	_
3	sequence	sequence	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	core	core	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	motif	motif	NN	NN	_	4	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	(A/T)GATA(A/G)	(a/t)gata(a/g)	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	8	punct	_	_
12	for	for	IN	IN	_	15	case	_	_
13	GATA-binding	gata-binding	NN	NN	_	15	compound	_	_
14	family	family	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	8	nmod	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	thus	thus	RB	RB	_	18	advmod	_	_
18	suggests	suggest	VBZ	VBZ	_	4	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	involvement	involvement	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	these	these	DT	DT	_	24	det	_	_
23	family	family	NN	NN	_	24	compound	_	_
24	members	member	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	describe	describe	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cloning	cloning	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	GATA-4	gata-4	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	hGATA-4	hgata-4	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	show	show	VBP	VBP	_	6	conj	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	hGATA-4	hgata-4	NN	NN	_	20	nsubj	_	_
19	selectively	selectively	RB	RB	_	20	advmod	_	_
20	interacts	interact	VBZ	VBZ	_	16	ccomp	_	_
21	with	with	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	-70	-70	CD	CD	_	25	nummod	_	_
24	GATA	gata	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	20	nmod	_	_
26	within	within	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	IL-5	il-5	NN	NN	_	31	compound	_	_
29	proximal	proximal	JJ	JJ	_	31	amod	_	_
30	promoter	promoter	NN	NN	_	31	compound	_	_
31	region	region	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	promoter	promoter	NN	NN	_	9	nmod	_	_
3	deletion	deletion	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	2	cc	_	_
5	mutation	mutation	NN	NN	_	2	conj	_	_
6	analyses	analysis	NNS	NNS	_	2	dep	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	established	establish	VBD	VBD	_	0	root	_	_
10	this	this	DT	DT	_	11	det	_	_
11	region	region	NN	NN	_	9	dobj	_	_
12	as	as	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	positive	positive	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	hGATA-4	hgata-4	NN	NN	_	11	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	PMA/A23187	pma/a23187	NN	NN	_	6	conj	_	_
9	stimulation	stimulation	NN	NN	_	6	dep	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	IL-5	il-5	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	requirement	requirement	NN	NN	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	another	another	DT	DT	_	6	det	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	element	element	NN	NN	_	2	nmod	_	_
7	called	call	VBN	VBN	_	6	acl	_	_
8	CLE0	cle0	NN	NN	_	7	xcomp	_	_
9	,	,	,	,	_	6	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	lies	lie	VBZ	VBZ	_	6	acl:relcl	_	_
12	downstream	downstream	RB	RB	_	11	advmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	-70	-70	CD	CD	_	17	nummod	_	_
16	GATA	gata	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	ATL-16T	atl-16t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	mRNA	mrna	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	three	three	CD	CD	_	8	nummod	_	_
7	GATA-binding	gata-binding	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	hGATA-2	hgata-2	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	10	punct	_	_
12	hGATA-3	hgata-3	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	hGATA-4	hgata-4	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	each	each	DT	DT	_	20	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	them	they	PRP	PRP	_	17	nmod	_	_
20	has	have	VBZ	VBZ	_	3	conj	_	_
21	a	a	DT	DT	_	22	det	_	_
22	potential	potential	NN	NN	_	20	dobj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	bind	bind	VB	VB	_	22	acl	_	_
25	to	to	TO	TO	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	consensus	consensus	NN	NN	_	29	compound	_	_
28	(A/T)GATA(G/A)	(a/t)gata(g/a)	NN	NN	_	29	compound	_	_
29	motif	motif	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	3	advmod	_	_
2	,	,	,	,	_	3	punct	_	_
3	using	use	VBG	VBG	_	0	root	_	_
4	ATL-16T	atl-16t	NN	NN	_	6	compound	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	extract	extract	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	3	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	demonstrated	demonstrate	VBD	VBD	_	3	parataxis	_	_
10	that	that	IN	IN	_	16	mark	_	_
11	GATA-4	gata-4	NN	NN	_	16	nsubj	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	the	the	DT	DT	_	16	det	_	_
14	only	only	RB	RB	_	16	advmod	_	_
15	GATA-binding	gata-binding	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	9	ccomp	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	forms	form	VBZ	VBZ	_	16	acl:relcl	_	_
19	specific	specific	JJ	JJ	_	21	amod	_	_
20	DNA-protein	dna-protein	JJ	JJ	_	21	amod	_	_
21	complex	complex	NN	NN	_	18	dobj	_	_
22	with	with	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	-70	-70	CD	CD	_	26	nummod	_	_
25	GATA	gata	NN	NN	_	26	compound	_	_
26	site	site	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	14	nsubj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	extracts	extract	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	COS	cos	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	expressing	express	VBG	VBG	_	10	acl	_	_
12	GATA-binding	gata-binding	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	11	dobj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	GATA-4	gata-4	NN	NN	_	17	nsubj	_	_
17	has	have	VBZ	VBZ	_	14	ccomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	highest	highest	JJS	JJS	_	21	amod	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	affinity	affinity	NN	NN	_	17	dobj	_	_
22	to	to	TO	TO	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	-70	-70	CD	CD	_	26	nummod	_	_
25	GATA	gata	NN	NN	_	26	compound	_	_
26	site	site	NN	NN	_	21	nmod	_	_
27	among	among	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	three	three	CD	CD	_	31	nummod	_	_
30	GATA-binding	gata-binding	JJ	JJ	_	31	amod	_	_
31	proteins	protein	NNS	NNS	_	21	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	transactivation	transactivation	NN	NN	_	4	compound	_	_
4	ability	ability	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	compared	compare	VBN	VBN	_	12	advcl	_	_
7	among	among	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	three	three	CD	CD	_	6	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	GATA-4	gata-4	NN	NN	_	12	nsubj	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	highest	highest	JJS	JJS	_	15	amod	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	selective	selective	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GATA-4	gata-4	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	regulation	regulation	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-5	il-5	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	circumstance	circumstance	NN	NN	_	12	nmod	_	_
20	where	where	WRB	WRB	_	28	advmod	_	_
21	multiple	multiple	JJ	JJ	_	22	amod	_	_
22	members	member	NNS	NNS	_	28	nsubjpass	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	GATA-binding	gata-binding	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	22	nmod	_	_
27	are	be	VBP	VBP	_	28	auxpass	_	_
28	expressed	express	VBN	VBN	_	19	acl:relcl	_	_
29	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Gs(alpha)	gs(alpha)	NN	NN	_	2	nmod	_	_
5	enhances	enhance	VBZ	VBZ	_	0	root	_	_
6	activation	activation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	adenylyl	adenylyl	NN	NN	_	10	compound	_	_
10	cyclase	cyclase	NN	NN	_	13	compound	_	_
11	signal	signal	NN	NN	_	13	compound	_	_
12	transduction	transduction	NN	NN	_	13	compound	_	_
13	cascade	cascade	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	stimulatory	stimulatory	JJ	JJ	_	6	amod	_	_
5	G	g	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	G(S)alpha	g(s)alpha	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	1	punct	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	vary	vary	VB	VB	_	0	root	_	_
12	over	over	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	3-fold	3-fold	JJ	JJ	_	15	amod	_	_
15	range	range	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	tissues	tissue	NNS	NNS	_	11	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	24	case	_	_
21	rodent	rodent	JJ	JJ	_	24	amod	_	_
22	central	central	JJ	JJ	_	24	amod	_	_
23	nervous	nervous	JJ	JJ	_	24	amod	_	_
24	system	system	NN	NN	_	18	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	offspring	offspring	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	alcoholics	alcoholic	NNS	NNS	_	5	nmod	_	_
8	have	have	VBP	VBP	_	0	root	_	_
9	higher	higher	JJR	JJR	_	10	amod	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	G(S)alpha	g(s)alpha	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	certain	certain	JJ	JJ	_	16	amod	_	_
16	tissues	tissue	NNS	NNS	_	13	nmod	_	_
17	compared	compare	VBN	VBN	_	20	case	_	_
18	with	with	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	offspring	offspring	NN	NN	_	8	advcl	_	_
21	of	of	IN	IN	_	22	case	_	_
22	nonalcoholics	nonalcoholic	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	research	research	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	test	test	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	hypothesis	hypothesis	NN	NN	_	8	dobj	_	_
11	that	that	IN	IN	_	15	mark	_	_
12	a	a	DT	DT	_	14	det	_	_
13	causal	causal	JJ	JJ	_	14	amod	_	_
14	relationship	relationship	NN	NN	_	15	nsubj	_	_
15	exists	exist	VBZ	VBZ	_	10	ccomp	_	_
16	between	between	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	level	level	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	expression	expression	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	G(S)alpha	g(s)alpha	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	induction	induction	NN	NN	_	18	conj	_	_
25	of	of	IN	IN	_	32	case	_	_
26	the	the	DT	DT	_	32	det	_	_
27	adenylyl	adenylyl	NN	NN	_	28	compound	_	_
28	cyclase	cyclase	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	AC	ac	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	cascade	cascade	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	methodology	methodology	NN	NN	_	3	nsubj	_	_
3	employed	employ	VBD	VBD	_	0	root	_	_
4	transient	transient	JJ	JJ	_	5	amod	_	_
5	transfection	transfection	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	HEK	hek	NN	NN	_	9	compound	_	_
8	293	293	CD	CD	_	9	nummod	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	cDNA	cdna	NN	NN	_	5	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	52-kDa	52-kda	JJ	JJ	_	16	amod	_	_
16	form	form	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	G(S)alpha	g(s)alpha	NN	NN	_	16	nmod	_	_
19	under	under	IN	IN	_	20	case	_	_
20	regulation	regulation	NN	NN	_	5	nmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	inducible	inducible	JJ	JJ	_	24	amod	_	_
23	metallothionein	metallothionein	NN	NN	_	24	compound	_	_
24	promoters	promoter	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Transfectants	transfectant	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	exposed	expose	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	varying	vary	VBG	VBG	_	6	amod	_	_
6	concentrations	concentration	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	0-125	0-125	CD	CD	_	9	nummod	_	_
9	microM	microm	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	of	of	IN	IN	_	13	case	_	_
12	zinc	zinc	NN	NN	_	13	compound	_	_
13	sulfate	sulfate	NN	NN	_	6	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	produced	produce	VBD	VBD	_	6	acl:relcl	_	_
16	a	a	DT	DT	_	18	det	_	_
17	3-fold	3-fold	JJ	JJ	_	18	amod	_	_
18	range	range	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	membrane	membrane	NN	NN	_	22	compound	_	_
21	G(S)alpha	g(s)alpha	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	range	range	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	G(S)alpha	g(s)alpha	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	produced	produce	VBN	VBN	_	5	acl	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	mimic	mimic	VB	VB	_	8	xcomp	_	_
11	a	a	DT	DT	_	14	det	_	_
12	physiologically	physiologically	RB	RB	_	13	advmod	_	_
13	relevant	relevant	JJ	JJ	_	14	amod	_	_
14	spectrum	spectrum	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	G(S)alpha	g(s)alpha	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	membranes	membrane	NNS	NNS	_	17	nmod	_	_
20	derived	derive	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	tissues	tissue	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	rat	rat	NN	NN	_	26	compound	_	_
26	brain	brain	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	observed	observe	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	induction	induction	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	G(S)alpha	g(s)alpha	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	increased	increase	VBD	VBD	_	3	ccomp	_	_
10	constitutive	constitutive	JJ	JJ	_	9	dobj	_	_
11	as	as	RB	RB	_	10	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	stimulated	stimulate	VBN	VBN	_	10	conj	_	_
15	cAMP	camp	NN	NN	_	16	compound	_	_
16	accumulation	accumulation	NN	NN	_	10	dep	_	_
17	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	induction	induction	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	G(S)alpha	g(s)alpha	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	events	event	NNS	NNS	_	7	dobj	_	_
9	distal	distal	JJ	JJ	_	8	amod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	accumulation	accumulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	cAMP	camp	NN	NN	_	12	nmod	_	_
15	including	include	VBG	VBG	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	phosphorylation	phosphorylation	NN	NN	_	8	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	cAMP	camp	NN	NN	_	27	compound	_	_
24	response	response	NN	NN	_	27	compound	_	_
25	element	element	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	21	appos	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	activation	activation	NN	NN	_	17	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	cAMP-dependent	camp-dependent	JJ	JJ	_	34	amod	_	_
33	reporter	reporter	NN	NN	_	34	compound	_	_
34	genes	gene	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	studies	study	NNS	NNS	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	amount	amount	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	G(S)alpha	g(s)alpha	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	has	have	VBZ	VBZ	_	6	ccomp	_	_
14	a	a	DT	DT	_	16	det	_	_
15	marked	marked	JJ	JJ	_	16	amod	_	_
16	impact	impact	NN	NN	_	13	dobj	_	_
17	on	on	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	level	level	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	activity	activity	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	AC	ac	NN	NN	_	25	compound	_	_
25	cascade	cascade	NN	NN	_	21	nmod	_	_
26	from	from	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	membrane	membrane	NN	NN	_	25	nmod	_	_
29	through	through	IN	IN	_	32	case	_	_
30	to	to	TO	TO	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	nucleus	nucleus	NN	NN	_	25	acl	_	_
33	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	hypothesized	hypothesize	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	individuals	individual	NNS	NNS	_	13	nsubj	_	_
6	who	who	WP	WP	_	7	nsubj	_	_
7	differ	differ	VBP	VBP	_	5	acl:relcl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	G(S)alpha	g(s)alpha	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	differ	differ	VB	VB	_	3	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	certain	certain	JJ	JJ	_	20	amod	_	_
19	cAMP-dependent	camp-dependent	JJ	JJ	_	20	amod	_	_
20	genes	gene	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	during	during	IN	IN	_	10	case	_	_
6	sodium	sodium	NN	NN	_	7	dep	_	_
7	phenylacetate	phenylacetate	NN	NN	_	10	amod	_	_
8	induced	induce	VBD	VBD	_	7	dep	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	K562	k562	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	15	15	CD	CD	_	3	nummod	_	_
3	days	day	NNS	NNS	_	14	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	treatment	treatment	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	K562	k562	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	phenylacetate	phenylacetate	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	observed	observe	VBD	VBD	_	0	root	_	_
15	an	a	DT	DT	_	16	det	_	_
16	increase	increase	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	cellular	cellular	JJ	JJ	_	21	amod	_	_
20	hemoglobin	hemoglobin	NN	NN	_	21	compound	_	_
21	concentration	concentration	NN	NN	_	16	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	similar	similar	JJ	JJ	_	25	amod	_	_
25	increase	increase	NN	NN	_	14	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	gamma-globin	gamma-globin	NN	NN	_	31	compound	_	_
31	mRNA	mrna	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	Morphological	morphological	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	characteristic	characteristic	JJ	JJ	_	5	amod	_	_
5	features	feature	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	maturation	maturation	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	3	punct	_	_

1	At	at	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	same	same	JJ	JJ	_	4	amod	_	_
4	time	time	NN	NN	_	6	nmod	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	change	change	NN	NN	_	6	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	level	level	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	expression	expression	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	surface	surface	NN	NN	_	18	compound	_	_
18	antigenes	antigene	NNS	NNS	_	13	nmod	_	_
19	CD33	cd33	NN	NN	_	18	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	CD34	cd34	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	CD45	cd45	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	CD71	cd71	NN	NN	_	19	conj	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	glycophorin	glycophorin	NN	NN	_	28	compound	_	_
28	A	a	NN	NN	_	19	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Likewise	likewise	RB	RB	_	31	advmod	_	_
2	,	,	,	,	_	31	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	level	level	NN	NN	_	31	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	expression	expression	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	6	nmod	_	_
12	GATA-1	gata-1	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	GATA-2	gata-2	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	NF-E2	nf-e2	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	SCL	scl	NN	NN	_	12	conj	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	RBTN2	rbtn2	NN	NN	_	12	conj	_	_
21	,	,	,	,	_	6	punct	_	_
22	all	all	DT	DT	_	6	appos	_	_
23	expressed	express	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	27	case	_	_
25	untreated	untreated	JJ	JJ	_	27	amod	_	_
26	K562	k562	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	,	,	,	,	_	4	punct	_	_
29	did	do	VBD	VBD	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	increase	increase	VB	VB	_	0	root	_	_
32	during	during	IN	IN	_	37	case	_	_
33	sodium	sodium	NN	NN	_	35	nmod:npmod	_	_
34	phenylacetate	phenylacetate	NN	NN	_	35	nmod:npmod	_	_
35	induced	induced	JJ	JJ	_	37	amod	_	_
36	erythroid	erythroid	JJ	JJ	_	37	amod	_	_
37	differentiation	differentiation	NN	NN	_	31	nmod	_	_
38	.	.	.	.	_	31	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	Evi-1	evi-1	NN	NN	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	c-myb	c-myb	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	known	know	VBN	VBN	_	6	acl	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	inhibit	inhibit	VB	VB	_	11	xcomp	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	2	punct	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	decrease	decrease	VB	VB	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	sodium	sodium	NN	NN	_	6	compound	_	_
5	phenylacetate	phenylacetate	NN	NN	_	6	compound	_	_
6	treatment	treatment	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	K562	k562	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	increases	increase	VBZ	VBZ	_	2	ccomp	_	_
11	gamma-globin	gamma-globin	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	induces	induce	VBZ	VBZ	_	10	conj	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	maturation	maturation	NN	NN	_	14	dobj	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	judged	judge	VBN	VBN	_	10	advcl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	morphology	morphology	NN	NN	_	18	nmod	_	_
21	without	without	IN	IN	_	22	mark	_	_
22	affecting	affect	VBG	VBG	_	10	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	erythroid	erythroid	JJ	JJ	_	29	amod	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factors	factor	NNS	NNS	_	24	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	some	some	DT	DT	_	35	nsubjpass	_	_
32	of	of	IN	IN	_	33	case	_	_
33	which	which	WDT	WDT	_	31	nmod	_	_
34	are	be	VBP	VBP	_	35	auxpass	_	_
35	known	know	VBN	VBN	_	29	acl:relcl	_	_
36	to	to	TO	TO	_	38	mark	_	_
37	be	be	VB	VB	_	38	auxpass	_	_
38	involved	involve	VBN	VBN	_	35	xcomp	_	_
39	in	in	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	regulation	regulation	NN	NN	_	38	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	beta-like	beta-like	JJ	JJ	_	45	amod	_	_
44	globin	globin	NN	NN	_	45	compound	_	_
45	genes	gene	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	8	case	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	relation	relation	NN	NN	_	2	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	age	age	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	to	to	TO	TO	_	16	case	_	_
15	sport	sport	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	GR	gr	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	ubiquitous	ubiquitous	JJ	JJ	_	8	amod	_	_
8	molecules	molecule	NNS	NNS	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	present	present	JJ	JJ	_	8	conj	_	_
12	also	also	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	hippocampus	hippocampus	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	in	in	IN	IN	_	20	case	_	_
18	several	several	JJ	JJ	_	20	amod	_	_
19	other	other	JJ	JJ	_	20	amod	_	_
20	nervous	nervous	JJ	JJ	_	15	conj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	immune	immune	JJ	JJ	_	20	conj	_	_
23	tissues	tissue	NNS	NNS	_	20	dep	_	_
24	.	.	.	.	_	8	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PBMCs	pbmc	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	good	good	JJ	JJ	_	11	amod	_	_
11	model	model	NN	NN	_	0	root	_	_
12	for	for	IN	IN	_	13	case	_	_
13	studies	study	NNS	NNS	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	GR	gr	NNS	NNS	_	13	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	humans	human	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	cop	_	_
3	important	important	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	5	mark	_	_
5	maintaining	maintain	VBG	VBG	_	3	advcl	_	_
6	cellular	cellular	JJ	JJ	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	humoral	humoral	JJ	JJ	_	6	conj	_	_
9	homeostasis	homeostasis	NN	NN	_	6	dep	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	key	key	JJ	JJ	_	13	amod	_	_
13	mediators	mediator	NNS	NNS	_	3	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	neuroendocrine-immune	neuroendocrine-immune	JJ	JJ	_	16	amod	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	interactions	interaction	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	cortisol	cortisol	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	immunosuppressive	immunosuppressive	JJ	JJ	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	reduces	reduce	VBZ	VBZ	_	6	conj	_	_
9	GR	gr	NNS	NNS	_	10	compound	_	_
10	concentration	concentration	NN	NN	_	8	dobj	_	_
11	both	both	CC	CC	_	13	dep	_	_
12	in	in	IN	IN	_	13	case	_	_
13	nervous	nervous	JJ	JJ	_	6	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	immune	immune	JJ	JJ	_	13	conj	_	_
16	systems	system	NNS	NNS	_	13	dep	_	_
17	.	.	.	.	_	6	punct	_	_

1	Variation	variation	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	healthy	healthy	JJ	JJ	_	7	amod	_	_
6	aged	aged	JJ	JJ	_	5	dep	_	_
7	subjects	subject	NNS	NNS	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	athletes	athlete	NNS	NNS	_	7	conj	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Prompted	prompt	VBN	VBN	_	0	root	_	_
2	by	by	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	investigated	investigate	VBN	VBN	_	1	parataxis	_	_
9	in	in	IN	IN	_	10	case	_	_
10	man	man	NN	NN	_	8	nmod	_	_
11	a	a	DT	DT	_	13	det	_	_
12	possible	possible	JJ	JJ	_	13	amod	_	_
13	relationship	relationship	NN	NN	_	8	dobj	_	_
14	between	between	IN	IN	_	17	case	_	_
15	GR	gr	NNS	NNS	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	capacity	capacity	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	PBMCs	pbmc	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	age	age	NN	NN	_	17	conj	_	_
23	,	,	,	,	_	8	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	relation	relation	NN	NN	_	8	nmod	_	_
26	also	also	RB	RB	_	25	advmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	plasma	plasma	NN	NN	_	25	nmod	_	_
29	testosterone	testosterone	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	28	cc	_	_
31	cortisol	cortisol	NN	NN	_	28	conj	_	_
32	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	same	same	JJ	JJ	_	3	amod	_	_
3	parameters	parameter	NNS	NNS	_	6	nsubjpass	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	examined	examine	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	group	group	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	soccer	soccer	NN	NN	_	12	compound	_	_
12	players	player	NNS	NNS	_	9	nmod	_	_
13	for	for	IN	IN	_	14	case	_	_
14	comparison	comparison	NN	NN	_	6	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	sedentary	sedentary	JJ	JJ	_	18	amod	_	_
18	group	group	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	GR	gr	NNS	NNS	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	capacity	capacity	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	higher	higher	JJR	JJR	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	younger	younger	JJR	JJR	_	8	amod	_	_
8	subjects	subject	NNS	NNS	_	5	nmod	_	_
9	than	than	IN	IN	_	12	case	_	_
10	in	in	IN	IN	_	12	case	_	_
11	older	older	JJR	JJR	_	12	amod	_	_
12	ones	one	NNS	NNS	_	5	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	lower	lower	JJR	JJR	_	5	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	group	group	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	athletes	athlete	NNS	NNS	_	18	nmod	_	_
21	than	than	IN	IN	_	24	case	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	younger	younger	JJR	JJR	_	15	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	older	older	JJR	JJR	_	24	conj	_	_
27	sedentary	sedentary	JJ	JJ	_	28	amod	_	_
28	subjects	subject	NNS	NNS	_	24	dep	_	_
29	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	sedentary	sedentary	JJ	JJ	_	4	amod	_	_
4	group	group	NN	NN	_	9	nmod	_	_
5	a	a	DT	DT	_	7	det	_	_
6	negative	negative	JJ	JJ	_	7	amod	_	_
7	correlation	correlation	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	present	present	JJ	JJ	_	0	root	_	_
10	between	between	IN	IN	_	13	case	_	_
11	GR	gr	NNS	NNS	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	capacity	capacity	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	age	age	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	Plasma	plasma	NN	NN	_	2	compound	_	_
2	cortisol	cortisol	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	higher	higher	JJR	JJR	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	testosterone	testosterone	NN	NN	_	7	dep	_	_
7	lower	lower	JJR	JJR	_	4	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	athletes	athlete	NNS	NNS	_	7	dep	_	_
11	;	;	:	:	_	4	punct	_	_
12	they	they	PRP	PRP	_	15	nsubjpass	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	negatively	negatively	RB	RB	_	15	advmod	_	_
15	correlated	correlate	VBN	VBN	_	4	parataxis	_	_
16	in	in	IN	IN	_	17	case	_	_
17	athletes	athlete	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	positively	positively	RB	RB	_	20	advmod	_	_
20	correlated	correlate	VBN	VBN	_	15	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	sedentary	sedentary	JJ	JJ	_	24	amod	_	_
24	subjects	subject	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	for	for	IN	IN	_	4	case	_	_
4	athletes	athlete	NNS	NNS	_	2	nmod	_	_
5	agree	agree	VBP	VBP	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
8	lower	lower	JJR	JJR	_	9	dep	_	_
9	anabolic/catabolic	anabolic/catabolic	JJ	JJ	_	10	amod	_	_
10	balance	balance	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	reduced	reduce	VBN	VBN	_	6	amod	_	_
5	GR	gr	NNS	NNS	_	6	compound	_	_
6	levels	level	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	relation	relation	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	age	age	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	sport	sport	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	conj	_	_
14	could	could	MD	MD	_	15	aux	_	_
15	involve	involve	VB	VB	_	0	root	_	_
16	a	a	DT	DT	_	17	det	_	_
17	loss	loss	NN	NN	_	15	dobj	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	an	a	DT	DT	_	20	det	_	_
20	involution	involution	NN	NN	_	17	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	synthesis	synthesis	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	However	however	RB	RB	_	25	advmod	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	possibilities	possibility	NNS	NNS	_	25	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	such	such	JJ	JJ	_	8	case	_	_
6	as	as	IN	IN	_	5	mwe	_	_
7	altered	altered	JJ	JJ	_	8	amod	_	_
8	distribution	distribution	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	subpopulations	subpopulation	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	with	with	IN	IN	_	20	case	_	_
18	different	different	JJ	JJ	_	20	amod	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	production	production	NN	NN	_	15	conj	_	_
21	,	,	,	,	_	3	punct	_	_
22	can	can	MD	MD	_	25	aux	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	excluded	exclude	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	neuroendocrine-immune	neuroendocrine-immune	JJ	JJ	_	3	amod	_	_
3	interactions	interaction	NNS	NNS	_	6	nsubj	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	responsible	responsible	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	reduced	reduce	VBN	VBN	_	10	amod	_	_
9	GR	gr	NNS	NNS	_	10	compound	_	_
10	levels	level	NNS	NNS	_	6	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	age	age	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	sport	sport	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	conj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	man	man	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Rescue	rescue	NN	NN	_	0	root	_	_
2	by	by	IN	IN	_	3	case	_	_
3	cytokines	cytokine	NNS	NNS	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	apoptotic	apoptotic	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	death	death	NN	NN	_	1	nmod	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	deprivation	deprivation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	antigen-specific	antigen-specific	JJ	JJ	_	17	amod	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	clones	clone	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	control	control	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	survival	survival	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	death	death	NN	NN	_	5	conj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	of	of	IN	IN	_	12	case	_	_
11	central	central	JJ	JJ	_	12	amod	_	_
12	importance	importance	NN	NN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	tissues	tissue	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	high	high	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	turnover	turnover	NN	NN	_	14	nmod	_	_
19	such	such	JJ	JJ	_	23	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	the	the	DT	DT	_	23	det	_	_
22	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
23	system	system	NN	NN	_	14	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	IL-2	il-2	NN	NN	_	11	compound	_	_
10	deprivation-induced	deprivation-induced	JJ	JJ	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	antigen-specific	antigen-specific	JJ	JJ	_	17	amod	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	helper	helper	NN	NN	_	17	compound	_	_
17	clones	clone	NNS	NNS	_	11	nmod	_	_
18	with	with	IN	IN	_	22	case	_	_
19	different	different	JJ	JJ	_	22	amod	_	_
20	cytokine	cytokine	NN	NN	_	22	compound	_	_
21	production	production	NN	NN	_	22	compound	_	_
22	profiles	profile	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	IL-2	il-2	NN	NN	_	13	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	interferon-alpha	interferon-alpha	NN	NN	_	4	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IFN-alpha	ifn-alpha	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	4	punct	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	IFN-beta	ifn-beta	NN	NN	_	4	conj	_	_
13	inhibited	inhibit	VBD	VBD	_	2	ccomp	_	_
14	IL-2	il-2	NN	NN	_	16	compound	_	_
15	deprivation	deprivation	NN	NN	_	16	compound	_	_
16	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	Th0	th0	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	Th1	th1	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	Th2	th2	NN	NN	_	18	conj	_	_
24	clones	clone	NNS	NNS	_	18	dep	_	_
25	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IL-2	il-2	NN	NN	_	6	nsubj	_	_
6	protects	protect	VBZ	VBZ	_	3	ccomp	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	clones	clone	NNS	NNS	_	6	dobj	_	_
10	from	from	IN	IN	_	13	case	_	_
11	IL-2	il-2	NN	NN	_	13	compound	_	_
12	deprivation	deprivation	NN	NN	_	13	compound	_	_
13	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
14	accompanying	accompany	VBG	VBG	_	6	xcomp	_	_
15	active	active	JJ	JJ	_	16	amod	_	_
16	proliferation	proliferation	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	enhanced	enhance	VBN	VBN	_	19	amod	_	_
19	expression	expression	NN	NN	_	16	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	P53	p53	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	Rb	rb	NN	NN	_	21	conj	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	Bcl-xL	bcl-xl	NN	NN	_	26	compound	_	_
26	proteins	protein	NNS	NNS	_	21	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	5	nsubj	_	_
5	rescued	rescue	VBD	VBD	_	0	root	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	clones	clone	NNS	NNS	_	5	dobj	_	_
9	from	from	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
11	without	without	IN	IN	_	13	case	_	_
12	active	active	JJ	JJ	_	13	amod	_	_
13	proliferation	proliferation	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	expression	expression	NN	NN	_	24	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	apoptosis-associated	apoptosis-associated	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	tested	test	VBN	VBN	_	19	acl	_	_
21	so	so	RB	RB	_	22	advmod	_	_
22	far	far	JJ	JJ	_	20	advmod	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	unaffected	unaffected	JJ	JJ	_	5	conj	_	_
25	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	cop	_	_
4	due	due	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	fact	fact	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	14	nsubj	_	_
11	treated	treat	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	IL-2	il-2	NN	NN	_	11	nmod	_	_
14	contained	contain	VBD	VBD	_	7	ccomp	_	_
15	those	those	DT	DT	_	14	dobj	_	_
16	located	located	JJ	JJ	_	15	amod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	S	s	NN	NN	_	21	compound	_	_
19	+	+	CC	CC	_	18	cc	_	_
20	G2/M	g2/m	NN	NN	_	18	conj	_	_
21	phases	phase	NNS	NNS	_	16	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	cycle	cycle	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	14	punct	_	_
27	whereas	whereas	IN	IN	_	38	mark	_	_
28	the	the	DT	DT	_	30	det	_	_
29	vast	vast	JJ	JJ	_	30	amod	_	_
30	majority	majority	NN	NN	_	38	nsubj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	treated	treat	VBN	VBN	_	33	acl	_	_
35	with	with	IN	IN	_	36	case	_	_
36	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	34	nmod	_	_
37	were	be	VBD	VBD	_	38	cop	_	_
38	located	located	JJ	JJ	_	14	advcl	_	_
39	in	in	IN	IN	_	41	case	_	_
40	G0/G1	g0/g1	NN	NN	_	41	compound	_	_
41	phase	phase	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	4	punct	_	_

1	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	3	nsubj	_	_
2	specifically	specifically	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	translocation	translocation	NN	NN	_	5	conj	_	_
8	into	into	IN	IN	_	9	case	_	_
9	nucleus	nucleus	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	signal	signal	NN	NN	_	12	compound	_	_
12	transducers	transducer	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	activators	activator	NNS	NNS	_	21	compound	_	_
15	of	of	IN	IN	_	21	amod	_	_
16	transcription	transcription	NN	NN	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	21	punct	_	_
18	STAT	stat	NN	NN	_	21	compound	_	_
19	)	)	-RRB-	-RRB-	_	21	punct	_	_
20	2	2	CD	CD	_	21	nummod	_	_
21	protein	protein	NN	NN	_	12	conj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	clones	clone	NNS	NNS	_	3	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	over-expression	over-expression	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STAT2	stat2	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	transfection	transfection	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cDNA	cdna	NN	NN	_	8	nmod	_	_
12	prevented	prevent	VBD	VBD	_	0	root	_	_
13	apoptosis	apoptosis	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	clones	clone	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	shows	show	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	-beta	-beta	NN	NN	_	6	conj	_	_
9	mediate	mediate	VBP	VBP	_	4	ccomp	_	_
10	anti-apoptotic	anti-apoptotic	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	9	dobj	_	_
12	through	through	IN	IN	_	14	case	_	_
13	other	other	JJ	JJ	_	14	amod	_	_
14	pathways	pathway	NNS	NNS	_	9	nmod	_	_
15	than	than	IN	IN	_	16	case	_	_
16	that	that	DT	DT	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IL-2	il-2	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	growth	growth	NN	NN	_	23	compound	_	_
21	factor	factor	NN	NN	_	23	compound	_	_
22	deprivation	deprivation	NN	NN	_	23	compound	_	_
23	apoptosis	apoptosis	NN	NN	_	9	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	tumor	tumor	NN	NN	_	8	compound	_	_
6	necrosis	necrosis	NN	NN	_	8	compound	_	_
7	factor-alpha	factor-alpha	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	by	by	IN	IN	_	3	case	_	_
3	Egr-1	egr-1	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	c-Jun	c-jun	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	3	conj	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	3	dep	_	_
11	.	.	.	.	_	1	punct	_	_

1	Biosynthesis	biosynthesis	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	tumor	tumor	NN	NN	_	5	compound	_	_
4	necrosis	necrosis	NN	NN	_	5	compound	_	_
5	factor-alpha	factor-alpha	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	predominantly	predominantly	RB	RB	_	12	advmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	0	root	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
16	lineage	lineage	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	various	various	JJ	JJ	_	10	amod	_	_
8	cis-acting	cis-acting	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	5	nmod	_	_
11	in	in	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	lipopolysaccharide	lipopolysaccharide	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	LPS	lps	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	induction	induction	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	TNF-alpha	tnf-alpha	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	cells	cell	NNS	NNS	_	17	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	monocytic	monocytic	JJ	JJ	_	27	amod	_	_
27	lineage	lineage	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
5	THP-1	thp-1	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	transfected	transfect	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	plasmids	plasmid	NNS	NNS	_	7	nmod	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	various	various	JJ	JJ	_	12	amod	_	_
12	lengths	length	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	12	nmod	_	_
16	localized	localize	VBD	VBD	_	0	root	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	region	region	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	27	punct	_	_
23	-182	-182	CD	CD	_	27	nummod	_	_
24	to	to	TO	TO	_	27	dep	_	_
25	-37	-37	CD	CD	_	27	nummod	_	_
26	base	base	NN	NN	_	27	compound	_	_
27	pairs	pair	NNS	NNS	_	21	dep	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	bp	bp	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	)	)	-RRB-	-RRB-	_	27	punct	_	_
32	that	that	WDT	WDT	_	34	nsubjpass	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	required	require	VBN	VBN	_	18	acl:relcl	_	_
35	for	for	IN	IN	_	37	case	_	_
36	optimal	optimal	JJ	JJ	_	37	amod	_	_
37	transcription	transcription	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	TNF-alpha	tnf-alpha	NN	NN	_	41	compound	_	_
41	gene	gene	NN	NN	_	37	nmod	_	_
42	in	in	IN	IN	_	43	case	_	_
43	response	response	NN	NN	_	37	nmod	_	_
44	to	to	TO	TO	_	45	case	_	_
45	LPS	lps	NN	NN	_	43	nmod	_	_
46	.	.	.	.	_	16	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	regions	region	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	:	:	:	:	_	4	punct	_	_
6	region	region	NN	NN	_	14	nsubj	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	-182	-182	CD	CD	_	12	nummod	_	_
10	to	to	TO	TO	_	12	dep	_	_
11	-162	-162	CD	CD	_	12	nummod	_	_
12	bp	bp	NN	NN	_	6	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	contained	contain	VBD	VBD	_	4	parataxis	_	_
15	an	a	DT	DT	_	18	det	_	_
16	overlapping	overlap	VBG	VBG	_	18	amod	_	_
17	Sp1/Egr-1	sp1/egr-1	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	14	dobj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	region	region	NN	NN	_	28	nsubj	_	_
22	II	ii	CD	CD	_	21	nummod	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	-119	-119	CD	CD	_	26	nummod	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	-88	-88	CD	CD	_	21	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	contained	contain	VBD	VBD	_	14	conj	_	_
29	CRE	cre	NN	NN	_	28	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	NF-kappaB	nf-kappab	NN	NN	_	36	compound	_	_
32	(	(	-LRB-	-LRB-	_	36	punct	_	_
33	designated	designate	VBN	VBN	_	36	amod	_	_
34	kappaB3	kappab3	NN	NN	_	36	compound	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	sites	site	NNS	NNS	_	29	conj	_	_
37	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	unstimulated	unstimulated	JJ	JJ	_	3	amod	_	_
3	THP-1	thp-1	NN	NN	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	CRE-binding	cre-binding	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	17	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	,	,	,	,	_	6	punct	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	lesser	lesser	JJR	JJR	_	12	amod	_	_
12	extent	extent	NN	NN	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	c-Jun	c-jun	NN	NN	_	15	compound	_	_
15	complexes	complex	NNS	NNS	_	6	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	bind	bind	VB	VB	_	17	xcomp	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	CRE	cre	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	3	nsubj	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	c-Jun-containing	c-jun-containing	JJ	JJ	_	8	amod	_	_
8	complexes	complex	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	LPS	lps	NN	NN	_	5	compound	_	_
5	stimulation	stimulation	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	binding	binding	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	cognate	cognate	JJ	JJ	_	12	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	Egr-1	egr-1	NN	NN	_	8	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	kappaB3	kappab3	NN	NN	_	15	conj	_	_
18	sites	site	NNS	NNS	_	15	dep	_	_
19	,	,	,	,	_	15	punct	_	_
20	which	which	WDT	WDT	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	identified	identify	VBN	VBN	_	15	acl:relcl	_	_
23	as	as	IN	IN	_	24	case	_	_
24	Egr-1	egr-1	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	p50/p65	p50/p65	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	respectively	respectively	RB	RB	_	22	advmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	CRE	cre	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	kappaB3	kappab3	NN	NN	_	2	conj	_	_
5	sites	site	NNS	NNS	_	2	dep	_	_
6	in	in	IN	IN	_	7	case	_	_
7	region	region	NN	NN	_	2	nmod	_	_
8	II	ii	CD	CD	_	7	nummod	_	_
9	together	together	RB	RB	_	10	advmod	_	_
10	conferred	confer	VBD	VBD	_	0	root	_	_
11	strong	strong	JJ	JJ	_	13	amod	_	_
12	LPS	lps	NN	NN	_	13	compound	_	_
13	responsiveness	responsiveness	NN	NN	_	10	dobj	_	_
14	to	to	TO	TO	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	heterologous	heterologous	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	whereas	whereas	IN	IN	_	22	mark	_	_
20	individually	individually	RB	RB	_	22	advmod	_	_
21	they	they	PRP	PRP	_	22	nsubj	_	_
22	failed	fail	VBD	VBD	_	10	advcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	provide	provide	VB	VB	_	22	xcomp	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	increasing	increase	VBG	VBG	_	14	csubj	_	_
4	the	the	DT	DT	_	5	det	_	_
5	spacing	spacing	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	CRE	cre	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	kappaB3	kappab3	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	8	conj	_	_
13	completely	completely	RB	RB	_	14	advmod	_	_
14	abolished	abolish	VBD	VBD	_	0	root	_	_
15	LPS	lps	NN	NN	_	16	compound	_	_
16	induction	induction	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	14	punct	_	_
18	suggesting	suggest	VBG	VBG	_	14	advcl	_	_
19	a	a	DT	DT	_	21	det	_	_
20	cooperative	cooperative	JJ	JJ	_	21	amod	_	_
21	interaction	interaction	NN	NN	_	18	dobj	_	_
22	between	between	IN	IN	_	24	case	_	_
23	c-Jun	c-jun	NN	NN	_	24	compound	_	_
24	complexes	complex	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	p50/p65	p50/p65	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	maximal	maximal	JJ	JJ	_	7	amod	_	_
6	LPS	lps	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	TNF-alpha	tnf-alpha	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	16	case	_	_
15	concerted	concert	VBN	VBN	_	16	amod	_	_
16	participation	participation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	24	case	_	_
18	at	at	IN	IN	_	19	case	_	_
19	least	least	JJS	JJS	_	20	nmod:npmod	_	_
20	two	two	CD	CD	_	24	nummod	_	_
21	separate	separate	JJ	JJ	_	24	amod	_	_
22	cis-acting	cis-acting	JJ	JJ	_	24	amod	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	elements	element	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Inducible	inducible	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	coactivator	coactivator	NN	NN	_	7	compound	_	_
7	BOB.1/OBF.1	bob.1/obf.1	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	-LSB-	-lsb-	-LRB-	-LRB-	_	12	punct	_	_
12	see	see	VB	VB	_	2	dep	_	_
13	comments	comment	NNS	NNS	_	12	dobj	_	_
14	-RSB-	-rsb-	-RRB-	-RRB-	_	12	punct	_	_

1	BOB.1/OBF.1	bob.1/obf.1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	coactivator	coactivator	NN	NN	_	0	root	_	_
6	that	that	WDT	WDT	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	expressed	express	VBN	VBN	_	5	acl:relcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	interacts	interact	VBZ	VBZ	_	9	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	Oct1	oct1	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	Oct2	oct2	NN	NN	_	17	conj	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	17	dep	_	_
22	.	.	.	.	_	5	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	activation	activation	NN	NN	_	23	nmod	_	_
3	of	of	IN	IN	_	6	case	_	_
4	Jurkat	jurkat	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	murine	murine	JJ	JJ	_	10	amod	_	_
10	thymocytes	thymocyte	NNS	NNS	_	6	conj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	esters	ester	NNS	NNS	_	2	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ionomycin	ionomycin	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	23	punct	_	_
17	BOB.1/OBF.1	bob.1/obf.1	NN	NN	_	23	nsubjpass	_	_
18	expression	expression	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	transactivation	transactivation	NN	NN	_	21	compound	_	_
21	function	function	NN	NN	_	17	conj	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	induced	induce	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	BOB.1/OBF.1	bob.1/obf.1	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	5	case	_	_
5	Ser184	ser184	NN	NN	_	3	nmod	_	_
6	both	both	CC	CC	_	9	cc:preconj	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vivo	vivo	FW	FW	_	9	advmod	_	_
9	and	and	CC	CC	_	3	advmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	this	this	DT	DT	_	15	det	_	_
15	modification	modification	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	3	conj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	inducible	inducible	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Mutation	mutation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Ser184	ser184	NN	NN	_	1	nmod	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	diminished	diminish	VBD	VBD	_	0	root	_	_
6	transactivation	transactivation	NN	NN	_	7	compound	_	_
7	function	function	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
13	that	that	IN	IN	_	25	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	activating	activate	VBG	VBG	_	16	amod	_	_
16	phosphorylation	phosphorylation	NN	NN	_	25	nsubj	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	inducible	inducible	JJ	JJ	_	16	acl:relcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	is	be	VBZ	VBZ	_	25	cop	_	_
24	constitutively	constitutively	RB	RB	_	25	advmod	_	_
25	present	present	JJ	JJ	_	12	ccomp	_	_
26	in	in	IN	IN	_	28	case	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	BOB.1/OBF.1	bob.1/obf.1	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	coactivator	coactivator	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	critically	critically	RB	RB	_	11	advmod	_	_
11	regulated	regulate	VBN	VBN	_	7	acl:relcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	posttranslational	posttranslational	JJ	JJ	_	14	amod	_	_
14	modifications	modification	NNS	NNS	_	11	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	mediate	mediate	VB	VB	_	11	xcomp	_	_
17	cell	cell	NN	NN	_	18	nmod:npmod	_	_
18	type-specific	type-specific	JJ	JJ	_	20	amod	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	shared	shared	JJ	JJ	_	4	amod	_	_
4	receptors	receptor	NNS	NNS	_	1	dep	_	_
5	,	,	,	,	_	4	punct	_	_
6	distinct	distinct	JJ	JJ	_	7	amod	_	_
7	functions	function	NNS	NNS	_	4	appos	_	_
8	.	.	.	.	_	1	punct	_	_

1	That	that	IN	IN	_	14	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	signal	signal	NN	NN	_	5	compound	_	_
4	transduction	transduction	NN	NN	_	5	compound	_	_
5	pathways	pathway	NNS	NNS	_	14	nsubj	_	_
6	used	use	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
10	IL-2	il-2	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-15	il-15	NN	NN	_	10	conj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	identical	identical	JJ	JJ	_	16	csubj	_	_
15	would	would	MD	MD	_	16	aux	_	_
16	suggest	suggest	VBP	VBP	_	0	root	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	these	these	DT	DT	_	19	det	_	_
19	cytokines	cytokine	NNS	NNS	_	20	nsubj	_	_
20	have	have	VBP	VBP	_	16	ccomp	_	_
21	redundant	redundant	JJ	JJ	_	22	amod	_	_
22	roles	role	NNS	NNS	_	20	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	development	development	NN	NN	_	20	nmod	_	_
26	;	;	:	:	_	16	punct	_	_
27	instead	instead	RB	RB	_	32	advmod	_	_
28	,	,	,	,	_	32	punct	_	_
29	IL-2	il-2	NN	NN	_	32	nsubj	_	_
30	is	be	VBZ	VBZ	_	32	cop	_	_
31	the	the	DT	DT	_	32	det	_	_
32	guardian	guardian	NN	NN	_	16	parataxis	_	_
33	of	of	IN	IN	_	36	case	_	_
34	thymus-derived	thymus-derived	JJ	JJ	_	36	amod	_	_
35	T-cell	t-cell	NN	NN	_	36	compound	_	_
36	homeostasis	homeostasis	NN	NN	_	32	nmod	_	_
37	,	,	,	,	_	32	punct	_	_
38	while	while	IN	IN	_	40	mark	_	_
39	interleukin-15	interleukin-15	NN	NN	_	40	nsubj	_	_
40	promotes	promote	VBZ	VBZ	_	32	advcl	_	_
41	extrathymic	extrathymic	JJ	JJ	_	42	amod	_	_
42	development	development	NN	NN	_	40	dobj	_	_
43	of	of	IN	IN	_	44	case	_	_
44	T	t	NN	NN	_	42	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	NK	nk	NN	NN	_	44	conj	_	_
47	cells	cell	NNS	NNS	_	44	dep	_	_
48	.	.	.	.	_	16	punct	_	_

1	Association	association	NN	NN	_	0	root	_	_
2	between	between	IN	IN	_	3	case	_	_
3	expression	expression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	intercellular	intercellular	JJ	JJ	_	7	amod	_	_
6	adhesion	adhesion	NN	NN	_	7	compound	_	_
7	molecule-1	molecule-1	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	integration	integration	NN	NN	_	3	conj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	T-cell-leukemia	t-cell-leukemia	JJ	JJ	_	14	amod	_	_
13	virus	virus	NN	NN	_	14	compound	_	_
14	type	type	NN	NN	_	9	nmod	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	adult	adult	JJ	JJ	_	20	amod	_	_
18	T-cell	t-cell	NN	NN	_	20	compound	_	_
19	leukemia	leukemia	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	3	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	25	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	intercellular	intercellular	JJ	JJ	_	11	amod	_	_
10	adhesion	adhesion	NN	NN	_	11	compound	_	_
11	molecule-1	molecule-1	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	ICAM-1	icam-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	23	case	_	_
16	adult	adult	JJ	JJ	_	23	amod	_	_
17	T	t	NN	NN	_	23	compound	_	_
18	cell	cell	NN	NN	_	23	compound	_	_
19	leukemia	leukemia	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	ATL	atl	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	cells	cell	NNS	NNS	_	7	nmod	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	high	high	JJ	JJ	_	3	ccomp	_	_
26	,	,	,	,	_	25	punct	_	_
27	whereas	whereas	IN	IN	_	32	mark	_	_
28	those	those	DT	DT	_	32	nsubj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	T-lymphoid	t-lymphoid	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	are	be	VBP	VBP	_	25	advcl	_	_
33	not	not	RB	RB	_	32	neg	_	_
34	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	45	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	factors	factor	NNS	NNS	_	4	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	influence	influence	VBP	VBP	_	6	acl:relcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	ICAM-1	icam-1	NN	NN	_	13	compound	_	_
13	molecules	molecule	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	45	punct	_	_
15	Northern	northern	NN	NN	_	17	compound	_	_
16	blot	blot	NN	NN	_	17	compound	_	_
17	analysis	analysis	NN	NN	_	45	nsubjpass	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	measure	measure	VB	VB	_	17	acl	_	_
20	the	the	DT	DT	_	22	det	_	_
21	expression	expression	NN	NN	_	22	compound	_	_
22	level	level	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	ICAM-1	icam-1	NN	NN	_	25	compound	_	_
25	mRNAs	mrna	NNS	NNS	_	22	nmod	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	Southern	southern	NN	NN	_	29	compound	_	_
28	blot	blot	NN	NN	_	29	compound	_	_
29	hybridization	hybridization	NN	NN	_	17	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	analyze	analyze	VB	VB	_	29	acl	_	_
32	the	the	DT	DT	_	33	det	_	_
33	integration	integration	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	43	case	_	_
35	human	human	JJ	JJ	_	38	amod	_	_
36	T-cell-leukemia	t-cell-leukemia	JJ	JJ	_	38	amod	_	_
37	virus	virus	NN	NN	_	38	compound	_	_
38	type	type	NN	NN	_	43	compound	_	_
39	1	1	CD	CD	_	38	nummod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	HTLV-1	htlv-1	NN	NN	_	38	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	provirus	provirus	NN	NN	_	33	nmod	_	_
44	were	be	VBD	VBD	_	45	auxpass	_	_
45	done	do	VBN	VBN	_	0	root	_	_
46	.	.	.	.	_	45	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	ICAM-1	icam-1	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	ATL	atl	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	generally	generally	RB	RB	_	12	advmod	_	_
12	higher	higher	JJR	JJR	_	0	root	_	_
13	than	than	IN	IN	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T-lymphoid	t-lymphoid	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	ILT-mat	ilt-mat	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	15	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	ATL16T(-)	atl16t(-)	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	conj	_	_
8	,	,	,	,	_	4	punct	_	_
9	although	although	IN	IN	_	13	mark	_	_
10	they	they	PRP	PRP	_	13	nsubj	_	_
11	were	be	VBD	VBD	_	13	cop	_	_
12	ATL	atl	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	15	dep	_	_
14	,	,	,	,	_	15	punct	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	rather	rather	RB	RB	_	17	advmod	_	_
17	low	low	JJ	JJ	_	20	amod	_	_
18	surface	surface	NN	NN	_	20	compound	_	_
19	ICAM-1	icam-1	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	15	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	ICAM-1	icam-1	NN	NN	_	23	compound	_	_
23	mRNA	mrna	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	conj	_	_
25	.	.	.	.	_	15	punct	_	_

1	Southern	southern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	hybridization	hybridization	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	two	two	CD	CD	_	12	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	four	four	CD	CD	_	7	conj	_	_
10	bands	band	NNS	NNS	_	7	dep	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	found	find	VBN	VBN	_	4	ccomp	_	_
13	in	in	IN	IN	_	14	case	_	_
14	ILT-mat	ilt-mat	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	ATL16T(-)	atl16t(-)	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	respectively	respectively	RB	RB	_	12	advmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	whereas	whereas	IN	IN	_	26	mark	_	_
22	&gt;	&gt;	JJR	JJR	_	23	advmod	_	_
23	10	10	CD	CD	_	24	nummod	_	_
24	bands	band	NNS	NNS	_	26	nsubjpass	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	detected	detect	VBN	VBN	_	12	advcl	_	_
27	in	in	IN	IN	_	30	case	_	_
28	other	other	JJ	JJ	_	30	amod	_	_
29	ATL	atl	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	monoclonal	monoclonal	JJ	JJ	_	6	amod	_	_
6	integration	integration	NN	NN	_	25	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	HTLV-1	htlv-1	NN	NN	_	9	compound	_	_
9	provirus	provirus	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	genome	genome	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cell	cell	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	especially	especially	RB	RB	_	19	advmod	_	_
18	the	the	DT	DT	_	19	det	_	_
19	number	number	NN	NN	_	6	appos	_	_
20	of	of	IN	IN	_	22	case	_	_
21	integration	integration	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	one	one	CD	CD	_	3	ccomp	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	for	for	IN	IN	_	30	case	_	_
30	induction	induction	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	ICAM-1	icam-1	NN	NN	_	33	compound	_	_
33	molecules	molecule	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	X2	x2	NN	NN	_	5	compound	_	_
5	box	box	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	activated	activate	VBN	VBN	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	1	nmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	DRA	dra	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	function	function	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	evolutionary	evolutionary	JJ	JJ	_	8	dep	_	_
8	conserved	conserve	VBN	VBN	_	10	amod	_	_
9	X2	x2	NN	NN	_	10	compound	_	_
10	box	box	NN	NN	_	4	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	promoter	promoter	NN	NN	_	4	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HLA-DRA	hla-dra	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	from	from	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	major	major	JJ	JJ	_	23	amod	_	_
22	histocompatibility	histocompatibility	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	17	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	MHC	mhc	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	28	case	_	_
28	resting	rest	VBG	VBG	_	23	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	activated	activate	VBN	VBN	_	28	conj	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	28	dep	_	_
33	.	.	.	.	_	2	punct	_	_

1	NF-X2	nf-x2	NN	NN	_	14	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	1	acl:relcl	_	_
5	members	member	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	AP-1/ATF/CREB	ap-1/atf/creb	NN	NN	_	9	compound	_	_
9	families	family	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	1	punct	_	_
14	interacts	interact	VBZ	VBZ	_	0	root	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	X2	x2	NN	NN	_	18	compound	_	_
18	box	box	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	5'-TGCGTCA-3'	5'-tgcgtca-3'	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	from	from	IN	IN	_	23	case	_	_
23	positions	position	NNS	NNS	_	18	nmod	_	_
24	-97	-97	CD	CD	_	26	compound	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	-91	-91	CD	CD	_	23	nummod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	DRA	dra	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	resting	rest	VBG	VBG	_	4	amod	_	_
3	Raji	raji	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	little	little	JJ	JJ	_	15	nsubjpass	_	_
7	to	to	TO	TO	_	8	case	_	_
8	no	no	DT	DT	_	6	nmod	_	_
9	binding	binding	NN	NN	_	8	dep	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	X2	x2	NN	NN	_	13	compound	_	_
13	box	box	NN	NN	_	6	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	observed	observe	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	sharp	sharp	JJ	JJ	_	3	amod	_	_
3	contrast	contrast	NN	NN	_	29	nmod	_	_
4	,	,	,	,	_	29	punct	_	_
5	in	in	IN	IN	_	7	case	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	29	nmod	_	_
8	treated	treat	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	phorbol	phorbol	NN	NN	_	12	compound	_	_
12	ester	ester	NN	NN	_	8	nmod	_	_
13	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	12	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TPA	tpa	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	29	punct	_	_
18	strong	strong	JJ	JJ	_	19	amod	_	_
19	interactions	interaction	NNS	NNS	_	29	nsubjpass	_	_
20	between	between	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	X2	x2	NN	NN	_	23	compound	_	_
23	box	box	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	NF-X2	nf-x2	NN	NN	_	23	conj	_	_
26	containing	contain	VBG	VBG	_	25	acl	_	_
27	c-Fos	c-fos	NN	NN	_	26	dobj	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	observed	observe	VBN	VBN	_	0	root	_	_
30	.	.	.	.	_	29	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	determined	determine	VBN	VBN	_	20	advcl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	transient	transient	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	RNA	rna	NN	NN	_	5	conj	_	_
8	analyses	analysis	NNS	NNS	_	5	dep	_	_
9	,	,	,	,	_	20	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	20	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	C	c	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PKC	pkc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	increased	increase	VBD	VBD	_	0	root	_	_
21	rates	rate	NNS	NNS	_	20	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	transcription	transcription	NN	NN	_	21	nmod	_	_
24	from	from	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	wild-type	wild-type	JJ	JJ	_	28	amod	_	_
27	DRA	dra	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	23	nmod	_	_
29	but	but	CC	CC	_	28	cc	_	_
30	not	not	RB	RB	_	34	neg	_	_
31	from	from	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	DRA	dra	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	28	conj	_	_
35	bearing	bear	VBG	VBG	_	34	acl	_	_
36	clustered	clustered	JJ	JJ	_	38	amod	_	_
37	point	point	NN	NN	_	38	compound	_	_
38	mutations	mutation	NNS	NNS	_	35	dobj	_	_
39	in	in	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	X2	x2	NN	NN	_	42	compound	_	_
42	box	box	NN	NN	_	35	nmod	_	_
43	.	.	.	.	_	20	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	co-expression	co-expression	NN	NN	_	9	nsubj	_	_
4	with	with	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	dominant	dominant	JJ	JJ	_	8	amod	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	c-Fos	c-fos	NN	NN	_	3	nmod	_	_
9	abolished	abolish	VBD	VBD	_	16	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	responsiveness	responsiveness	NN	NN	_	9	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	TPA	tpa	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	conclude	conclude	VBP	VBP	_	0	root	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	activated	activate	VBN	VBN	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	DRA	dra	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	depends	depend	VBZ	VBZ	_	16	ccomp	_	_
25	on	on	IN	IN	_	26	case	_	_
26	interactions	interaction	NNS	NNS	_	24	nmod	_	_
27	between	between	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	X2	x2	NN	NN	_	30	compound	_	_
30	box	box	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	NF-X2	nf-x2	NN	NN	_	30	conj	_	_
33	,	,	,	,	_	32	punct	_	_
34	which	which	WDT	WDT	_	35	nsubj	_	_
35	contains	contain	VBZ	VBZ	_	32	acl:relcl	_	_
36	c-Fos	c-fos	NN	NN	_	35	dobj	_	_
37	.	.	.	.	_	16	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	17	nsubj	_	_
5	downstream	downstream	JJ	JJ	_	4	advmod	_	_
6	of	of	IN	IN	_	15	case	_	_
7	the	the	DT	DT	_	15	det	_	_
8	human	human	JJ	JJ	_	15	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	15	compound	_	_
10	virus	virus	NN	NN	_	15	compound	_	_
11	type	type	NN	NN	_	15	compound	_	_
12	1	1	CD	CD	_	15	nummod	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	start	start	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	5	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	important	important	JJ	JJ	_	0	root	_	_
18	for	for	IN	IN	_	20	case	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	infectivity	infectivity	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	When	when	WRB	WRB	_	3	advmod	_	_
2	transcriptionally	transcriptionally	RB	RB	_	3	advmod	_	_
3	active	active	JJ	JJ	_	13	advcl	_	_
4	,	,	,	,	_	13	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
8	virus	virus	NN	NN	_	13	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HIV	hiv	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	promoter	promoter	NN	NN	_	8	dep	_	_
13	contains	contain	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	nucleosome-free	nucleosome-free	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	13	dobj	_	_
17	encompassing	encompass	VBG	VBG	_	16	acl	_	_
18	both	both	CC	CC	_	21	cc:preconj	_	_
19	the	the	DT	DT	_	21	det	_	_
20	promoter/enhancer	promoter/enhancer	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	17	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	a	a	DT	DT	_	25	det	_	_
24	large	large	JJ	JJ	_	25	amod	_	_
25	region	region	NN	NN	_	21	conj	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	255	255	CD	CD	_	28	nummod	_	_
28	nucleotides	nucleotide	NNS	NNS	_	25	dep	_	_
29	-LSB-	-lsb-	-LRB-	-LRB-	_	30	punct	_	_
30	nt	nt	NN	NN	_	28	appos	_	_
31	-RSB-	-rsb-	-RRB-	-RRB-	_	30	punct	_	_
32	)	)	-RRB-	-RRB-	_	28	punct	_	_
33	downstream	downstream	JJ	JJ	_	25	advmod	_	_
34	of	of	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	transcription	transcription	NN	NN	_	38	compound	_	_
37	start	start	NN	NN	_	38	compound	_	_
38	site	site	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	new	new	JJ	JJ	_	7	amod	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	sites	site	NNS	NNS	_	4	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	downstream	downstream	RB	RB	_	7	advmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	start	start	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	nt	nt	NN	NN	_	16	appos	_	_
19	465	465	CD	CD	_	18	nummod	_	_
20	to	to	TO	TO	_	18	dep	_	_
21	720	720	CD	CD	_	18	nummod	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	:	:	:	:	_	4	punct	_	_
24	three	three	CD	CD	_	26	nummod	_	_
25	AP-1	ap-1	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	4	dep	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	I	i	CD	CD	_	26	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	II	ii	CD	CD	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	III	iii	CD	CD	_	28	conj	_	_
34	)	)	-RRB-	-RRB-	_	28	punct	_	_
35	,	,	,	,	_	26	punct	_	_
36	an	a	DT	DT	_	38	det	_	_
37	AP3-like	ap3-like	JJ	JJ	_	38	amod	_	_
38	motif	motif	NN	NN	_	26	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	AP3-L	ap3-l	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	26	punct	_	_
43	a	a	DT	DT	_	50	det	_	_
44	downstream	downstream	JJ	JJ	_	50	amod	_	_
45	binding	binding	NN	NN	_	50	compound	_	_
46	factor	factor	NN	NN	_	50	compound	_	_
47	(	(	-LRB-	-LRB-	_	50	punct	_	_
48	DBF	dbf	NN	NN	_	50	compound	_	_
49	)	)	-RRB-	-RRB-	_	50	punct	_	_
50	site	site	NN	NN	_	26	conj	_	_
51	,	,	,	,	_	26	punct	_	_
52	and	and	CC	CC	_	26	cc	_	_
53	juxtaposed	juxtapose	VBN	VBN	_	55	amod	_	_
54	Sp1	sp1	NN	NN	_	55	compound	_	_
55	sites	site	NNS	NNS	_	26	conj	_	_
56	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	DBF	dbf	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	17	nsubj	_	_
9	is	be	VBZ	VBZ	_	17	cop	_	_
10	an	a	DT	DT	_	17	det	_	_
11	interferon-responsive	interferon-responsive	JJ	JJ	_	17	amod	_	_
12	factor	factor	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	IRF	irf	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	4	ccomp	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	AP3-L	ap3-l	NN	NN	_	22	compound	_	_
22	motif	motif	NN	NN	_	23	nsubj	_	_
23	binds	bind	VBZ	VBZ	_	17	conj	_	_
24	the	the	DT	DT	_	26	det	_	_
25	T-cell-specific	t-cell-specific	JJ	JJ	_	26	amod	_	_
26	factor	factor	NN	NN	_	23	dobj	_	_
27	NF-AT	nf-at	NN	NN	_	26	dep	_	_
28	.	.	.	.	_	4	punct	_	_

1	Mutations	mutation	NNS	NNS	_	14	nsubjpass	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	abolish	abolish	VBP	VBP	_	1	acl:relcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	each	each	DT	DT	_	8	det	_	_
8	factor	factor	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	cognate	cognate	JJ	JJ	_	12	amod	_	_
12	site	site	NN	NN	_	5	nmod	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	introduced	introduce	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	20	case	_	_
16	an	a	DT	DT	_	20	det	_	_
17	infectious	infectious	JJ	JJ	_	20	amod	_	_
18	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
19	molecular	molecular	JJ	JJ	_	20	amod	_	_
20	clone	clone	NN	NN	_	14	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	study	study	VB	VB	_	14	xcomp	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	effect	effect	NN	NN	_	22	dobj	_	_
25	on	on	IN	IN	_	26	case	_	_
26	HIV-1	hiv-1	NN	NN	_	24	nmod	_	_
27	transcription	transcription	NN	NN	_	26	dep	_	_
28	and	and	CC	CC	_	26	cc	_	_
29	replication	replication	NN	NN	_	26	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	Individual	individual	JJ	JJ	_	2	amod	_	_
2	mutation	mutation	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	DBF	dbf	NN	NN	_	2	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	AP3-L	ap3-l	NN	NN	_	5	conj	_	_
8	site	site	NN	NN	_	5	dep	_	_
9	as	as	RB	RB	_	2	cc	_	_
10	well	well	RB	RB	_	9	mwe	_	_
11	as	as	IN	IN	_	9	mwe	_	_
12	the	the	DT	DT	_	15	det	_	_
13	double	double	JJ	JJ	_	15	amod	_	_
14	mutation	mutation	NN	NN	_	15	compound	_	_
15	AP-1(III)/AP3-L	ap-1(iii)/ap3-l	NN	NN	_	2	conj	_	_
16	did	do	VBD	VBD	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	affect	affect	VB	VB	_	0	root	_	_
19	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
20	replication	replication	NN	NN	_	18	dobj	_	_
21	compared	compare	VBN	VBN	_	23	case	_	_
22	to	to	TO	TO	_	23	case	_	_
23	that	that	DT	DT	_	18	advcl	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	wild-type	wild-type	JJ	JJ	_	27	amod	_	_
27	virus	virus	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	proviruses	provirus	NNS	NNS	_	13	nsubj	_	_
5	carrying	carry	VBG	VBG	_	4	acl	_	_
6	mutations	mutation	NNS	NNS	_	5	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Sp1	sp1	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	5	nmod	_	_
11	were	be	VBD	VBD	_	13	cop	_	_
12	totally	totally	RB	RB	_	13	advmod	_	_
13	defective	defective	JJ	JJ	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	terms	term	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	replication	replication	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	Virus	virus	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	3	nsubj	_	_
3	occurred	occur	VBD	VBD	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	slightly	slightly	RB	RB	_	6	advmod	_	_
6	delayed	delay	VBN	VBN	_	7	amod	_	_
7	kinetics	kinetics	NNS	NNS	_	3	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	viruses	virus	NNS	NNS	_	7	nmod	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	combined	combined	JJ	JJ	_	12	amod	_	_
12	mutations	mutation	NNS	NNS	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	AP-1(III)	ap-1(iii)	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	AP3-L	ap3-l	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	DBF	dbf	NN	NN	_	21	compound	_	_
21	sites	site	NNS	NNS	_	15	conj	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	dep	_	_
25	AP3-L	ap3-l	NN	NN	_	15	conj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	DBF-sites	dbf-site	NNS	NNS	_	25	conj	_	_
28	,	,	,	,	_	3	punct	_	_
29	whereas	whereas	IN	IN	_	48	mark	_	_
30	viruses	virus	NNS	NNS	_	48	nsubj	_	_
31	mutated	mutate	VBN	VBN	_	30	acl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	dep	_	_
34	AP-1(I,II,III)	ap-1(i,ii,iii)	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	AP3-L	ap3-l	NN	NN	_	37	compound	_	_
37	sites	site	NNS	NNS	_	34	conj	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	in	in	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	dep	_	_
41	AP-1(I,II,III)	ap-1(i,ii,iii)	NN	NN	_	34	conj	_	_
42	,	,	,	,	_	41	punct	_	_
43	AP3-L	ap3-l	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	41	punct	_	_
45	and	and	CC	CC	_	41	cc	_	_
46	DBF	dbf	NN	NN	_	47	compound	_	_
47	sites	site	NNS	NNS	_	41	conj	_	_
48	exhibited	exhibit	VBD	VBD	_	3	advcl	_	_
49	a	a	DT	DT	_	53	det	_	_
50	severely	severely	RB	RB	_	51	advmod	_	_
51	defective	defective	JJ	JJ	_	53	amod	_	_
52	replicative	replicative	JJ	JJ	_	51	dep	_	_
53	phenotype	phenotype	NN	NN	_	48	dobj	_	_
54	.	.	.	.	_	3	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	RNA-packaging	rna-packaging	JJ	JJ	_	3	amod	_	_
3	defect	defect	NN	NN	_	6	nsubjpass	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	measured	measure	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	any	any	DT	DT	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	mutant	mutant	JJ	JJ	_	12	amod	_	_
12	viruses	virus	NNS	NNS	_	8	nmod	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	determined	determine	VBN	VBN	_	6	advcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	quantification	quantification	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
19	HIV	hiv	NN	NN	_	21	compound	_	_
20	genomic	genomic	JJ	JJ	_	21	amod	_	_
21	RNA	rna	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Measurement	measurement	NN	NN	_	24	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	after	after	IN	IN	_	12	case	_	_
11	transient	transient	JJ	JJ	_	12	amod	_	_
12	transfection	transfection	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
16	provirus	provirus	NN	NN	_	17	compound	_	_
17	DNA	dna	NN	NN	_	12	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	of	of	IN	IN	_	23	case	_	_
20	long	long	JJ	JJ	_	23	amod	_	_
21	terminal	terminal	JJ	JJ	_	23	amod	_	_
22	repeat-luciferase	repeat-luciferase	JJ	JJ	_	23	amod	_	_
23	constructs	construct	NNS	NNS	_	17	conj	_	_
24	showed	show	VBD	VBD	_	0	root	_	_
25	a	a	DT	DT	_	27	det	_	_
26	positive	positive	JJ	JJ	_	27	amod	_	_
27	correlation	correlation	NN	NN	_	24	dobj	_	_
28	between	between	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	transcriptional	transcriptional	JJ	JJ	_	27	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	replication	replication	NN	NN	_	30	conj	_	_
34	defects	defect	NNS	NNS	_	30	dep	_	_
35	for	for	IN	IN	_	37	case	_	_
36	most	most	JJS	JJS	_	37	amod	_	_
37	mutants	mutant	NNS	NNS	_	30	nmod	_	_
38	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	cytokine	cytokine	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	regulate	regulate	VBP	VBP	_	5	acl:relcl	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	5	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	12	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	critical	critical	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	maximal	maximal	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	many	many	JJ	JJ	_	18	amod	_	_
18	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
19	that	that	WDT	WDT	_	21	nsubjpass	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	involved	involve	VBN	VBN	_	18	acl:relcl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	pathogenesis	pathogenesis	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
27	diseases	disease	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	such	such	JJ	JJ	_	34	case	_	_
30	as	as	IN	IN	_	29	mwe	_	_
31	adult	adult	JJ	JJ	_	34	amod	_	_
32	respiratory	respiratory	JJ	JJ	_	34	amod	_	_
33	distress	distress	NN	NN	_	34	compound	_	_
34	syndrome	syndrome	NN	NN	_	27	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	ARDS	ards	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	sepsis	sepsis	NN	NN	_	40	compound	_	_
40	syndrome	syndrome	NN	NN	_	34	conj	_	_
41	.	.	.	.	_	12	punct	_	_

1	Activation	activation	NN	NN	_	9	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	regulation	regulation	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	tightly	tightly	RB	RB	_	9	advmod	_	_
9	controlled	control	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	group	group	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	inhibitory	inhibitory	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	I	i	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	15	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	sequester	sequester	VBP	VBP	_	15	acl:relcl	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	22	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	cytoplasm	cytoplasm	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	immune/inflammatory	immune/inflammatory	JJ	JJ	_	31	amod	_	_
30	effector	effector	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	signaled	signal	VBN	VBN	_	6	amod	_	_
6	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	ubiquitination	ubiquitination	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	proteolysis	proteolysis	NN	NN	_	6	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	I	i	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	6	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Liberated	liberate	VBN	VBN	_	3	amod	_	_
2	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	4	nsubj	_	_
4	migrates	migrate	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	nucleus	nucleus	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	where	where	WRB	WRB	_	11	advmod	_	_
10	it	it	PRP	PRP	_	11	nsubj	_	_
11	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	specific	specific	JJ	JJ	_	15	amod	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	activates	activate	VBZ	VBZ	_	11	conj	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	initiates	initiate	VBZ	VBZ	_	0	root	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	extracellular	extracellular	JJ	JJ	_	6	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	intracellular	intracellular	JJ	JJ	_	8	conj	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	events	event	NNS	NNS	_	8	dep	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	result	result	VBP	VBP	_	8	acl:relcl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	autoregulation	autoregulation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	inflammatory	inflammatory	JJ	JJ	_	20	amod	_	_
20	cascade	cascade	NN	NN	_	16	nmod	_	_
21	through	through	IN	IN	_	22	case	_	_
22	modulation	modulation	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Recently	recently	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	activation	activation	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	linked	link	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	ARDS	ards	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	9	conj	_	_
16	to	to	TO	TO	_	21	mark	_	_
17	be	be	VB	VB	_	21	cop	_	_
18	a	a	DT	DT	_	21	det	_	_
19	critical	critical	JJ	JJ	_	20	amod	_	_
20	proximal	proximal	JJ	JJ	_	21	amod	_	_
21	step	step	NN	NN	_	15	xcomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	initiation	initiation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	neutrophilic	neutrophilic	JJ	JJ	_	27	amod	_	_
27	inflammation	inflammation	NN	NN	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	animal	animal	NN	NN	_	30	compound	_	_
30	models	model	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Activation	activation	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vivo	vivo	FW	FW	_	7	advmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	treatment	treatment	NN	NN	_	7	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	antioxidants	antioxidant	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	corticosteroids	corticosteroid	NNS	NNS	_	13	appos	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	induction	induction	NN	NN	_	11	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	endotoxin	endotoxin	NN	NN	_	22	compound	_	_
22	tolerance	tolerance	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Identification	identification	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	more	more	RBR	RBR	_	4	advmod	_	_
4	specific	specific	JJ	JJ	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	efficacious	efficacious	JJ	JJ	_	4	conj	_	_
7	inhibitors	inhibitor	NNS	NNS	_	4	dep	_	_
8	of	of	IN	IN	_	11	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	4	nmod	_	_
12	might	might	MD	MD	_	13	aux	_	_
13	prove	prove	VB	VB	_	0	root	_	_
14	beneficial	beneficial	JJ	JJ	_	13	xcomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	treatment	treatment	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	cytokine-mediated	cytokine-mediated	JJ	JJ	_	21	amod	_	_
20	inflammatory	inflammatory	JJ	JJ	_	19	dep	_	_
21	diseases	disease	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Pancreatic	pancreatic	JJ	JJ	_	4	amod	_	_
2	islet	islet	NN	NN	_	4	compound	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	polymorphic	polymorphic	JJ	JJ	_	8	amod	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	markers	marker	NNS	NNS	_	4	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	hepatocyte	hepatocyte	NN	NN	_	12	dobj	_	_
14	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
15	factor-3alpha	factor-3alpha	NN	NN	_	13	dep	_	_
16	,	,	,	,	_	13	punct	_	_
17	-3beta	-3beta	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	-3gamma	-3gamma	NN	NN	_	13	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	-4gamma	-4gamma	NN	NN	_	13	conj	_	_
22	,	,	,	,	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	-6	-6	CD	CD	_	13	conj	_	_
25	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	genes	gene	NNS	NNS	_	13	nsubj	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	9	det	_	_
5	functionally	functionally	RB	RB	_	6	advmod	_	_
6	related	related	JJ	JJ	_	9	amod	_	_
7	hepatocyte	hepatocyte	NN	NN	_	9	compound	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	3	dobj	_	_
10	HNF-1alpha	hnf-1alpha	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	HNF-4alpha	hnf-4alpha	NN	NN	_	10	conj	_	_
13	play	play	VBP	VBP	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	critical	critical	JJ	JJ	_	16	amod	_	_
16	role	role	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	normal	normal	JJ	JJ	_	21	amod	_	_
19	pancreatic	pancreatic	JJ	JJ	_	21	amod	_	_
20	beta-cell	beta-cell	NN	NN	_	21	compound	_	_
21	function	function	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Mutations	mutation	NNS	NNS	_	7	nsubj	_	_
2	in	in	IN	IN	_	6	case	_	_
3	these	these	DT	DT	_	6	det	_	_
4	liver-enriched	liver-enriched	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	1	nmod	_	_
7	result	result	VBP	VBP	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	two	two	CD	CD	_	10	nummod	_	_
10	forms	form	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	early-onset	early-onset	JJ	JJ	_	15	amod	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	2	2	CD	CD	_	15	nummod	_	_
15	diabetes	diabetes	NNS	NNS	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	maturity-onset	maturity-onset	JJ	JJ	_	18	amod	_	_
18	diabetes	diabetes	NNS	NNS	_	10	dep	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	young	young	JJ	JJ	_	18	nmod	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
23	MODY	mody	NN	NN	_	18	appos	_	_
24	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_
25	)	)	-RRB-	-RRB-	_	18	punct	_	_
26	,	,	,	,	_	10	punct	_	_
27	MODY3	mody3	NN	NN	_	10	appos	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	MODY1	mody1	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	10	punct	_	_
31	which	which	WDT	WDT	_	33	nsubjpass	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	characterized	characterize	VBN	VBN	_	10	acl:relcl	_	_
34	by	by	IN	IN	_	38	case	_	_
35	impaired	impaired	JJ	JJ	_	36	amod	_	_
36	glucose-stimulated	glucose-stimulated	JJ	JJ	_	38	amod	_	_
37	insulin	insulin	NN	NN	_	38	compound	_	_
38	secretion	secretion	NN	NN	_	33	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	early	early	RB	RB	_	42	advmod	_	_
41	disease	disease	NN	NN	_	42	compound	_	_
42	onset	onset	NN	NN	_	38	conj	_	_
43	,	,	,	,	_	38	punct	_	_
44	and	and	CC	CC	_	38	cc	_	_
45	autosomal	autosomal	JJ	JJ	_	47	amod	_	_
46	dominant	dominant	JJ	JJ	_	47	amod	_	_
47	inheritance	inheritance	NN	NN	_	38	conj	_	_
48	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	hierarchy	hierarchy	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HNFs	hnf	NNS	NNS	_	3	nmod	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	16	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	cascade	cascade	NN	NN	_	9	nmod	_	_
14	might	might	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	responsible	responsible	JJ	JJ	_	6	ccomp	_	_
17	for	for	IN	IN	_	19	case	_	_
18	other	other	JJ	JJ	_	19	amod	_	_
19	forms	form	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	MODY	mody	NN	NN	_	19	nmod	_	_
22	and/or	and/or	CC	CC	_	19	cc	_	_
23	late-onset	late-onset	JJ	JJ	_	26	amod	_	_
24	type	type	NN	NN	_	26	compound	_	_
25	2	2	CD	CD	_	26	nummod	_	_
26	diabetes	diabetes	NNS	NNS	_	19	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	19	mark	_	_
8	HNF-3alpha	hnf-3alpha	NN	NN	_	19	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	-3beta	-3beta	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	-3gamma	-3gamma	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	-4gamma	-4gamma	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	-6	-6	CD	CD	_	8	conj	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	expressed	express	VBN	VBN	_	6	ccomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	pancreatic	pancreatic	JJ	JJ	_	22	amod	_	_
22	beta-cells	beta-cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	identification	identification	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	characterization	characterization	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	simple	simple	JJ	JJ	_	12	amod	_	_
9	tandem	tandem	JJ	JJ	_	12	amod	_	_
10	repeat	repeat	NN	NN	_	12	compound	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	polymorphisms	polymorphism	NNS	NNS	_	4	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	encoding	encode	VBG	VBG	_	15	acl	_	_
17	HNF-3alpha	hnf-3alpha	NN	NN	_	16	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	-3beta	-3beta	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	-3gamma	-3gamma	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	-4gamma	-4gamma	NN	NN	_	17	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	-6	-6	CD	CD	_	17	conj	_	_
27	and	and	CC	CC	_	4	cc	_	_
28	the	the	DT	DT	_	29	det	_	_
29	mapping	mapping	NN	NN	_	4	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	HNF-6	hnf-6	NN	NN	_	29	nmod	_	_
32	to	to	TO	TO	_	34	case	_	_
33	chromosome	chromosome	NN	NN	_	34	compound	_	_
34	bands	band	NNS	NNS	_	29	nmod	_	_
35	15q21.1-21.2	15q21.1-21.2	NN	NN	_	34	dep	_	_
36	by	by	IN	IN	_	40	case	_	_
37	fluorescence	fluorescence	NN	NN	_	40	compound	_	_
38	in	in	FW	FW	_	40	amod	_	_
39	situ	situ	FW	FW	_	38	dep	_	_
40	hybridization	hybridization	NN	NN	_	4	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	markers	marker	NNS	NNS	_	5	nsubj	_	_
3	will	will	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	cop	_	_
5	useful	useful	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	study	study	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	genetic	genetic	JJ	JJ	_	12	amod	_	_
12	variation	variation	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	pathogenesis	pathogenesis	NN	NN	_	7	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	type	type	NN	NN	_	22	compound	_	_
21	2	2	CD	CD	_	22	nummod	_	_
22	diabetes	diabetes	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	footprinting	footprinting	NN	NN	_	12	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	mutational	mutational	JJ	JJ	_	6	amod	_	_
6	analysis	analysis	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	proximal	proximal	JJ	JJ	_	11	amod	_	_
10	CD19	cd19	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	3	nmod	_	_
12	reveal	reveal	VBP	VBP	_	0	root	_	_
13	important	important	JJ	JJ	_	14	amod	_	_
14	roles	role	NNS	NNS	_	12	dobj	_	_
15	for	for	IN	IN	_	19	case	_	_
16	an	a	DT	DT	_	19	det	_	_
17	SP1/Egr-1	sp1/egr-1	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	a	a	DT	DT	_	23	det	_	_
22	novel	novel	JJ	JJ	_	23	amod	_	_
23	site	site	NN	NN	_	19	conj	_	_
24	termed	term	VBN	VBN	_	23	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	PyG	pyg	NN	NN	_	27	compound	_	_
27	box	box	NN	NN	_	24	xcomp	_	_
28	.	.	.	.	_	12	punct	_	_

1	CD19	cd19	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	begins	begin	VBZ	VBZ	_	0	root	_	_
4	at	at	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	pro-B	pro-b	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	stage	stage	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	such	such	JJ	JJ	_	4	advcl	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	serves	serve	VBZ	VBZ	_	0	root	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	good	good	JJ	JJ	_	8	amod	_	_
8	prototype	prototype	NN	NN	_	4	nmod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	8	nmod	_	_
13	whose	whose	WP$	WP$	_	14	nmod:poss	_	_
14	expression	expression	NN	NN	_	15	nsubj	_	_
15	begins	begin	VBZ	VBZ	_	12	acl:relcl	_	_
16	shortly	shortly	RB	RB	_	19	advmod	_	_
17	after	after	IN	IN	_	19	case	_	_
18	lineage	lineage	NN	NN	_	19	compound	_	_
19	commitment	commitment	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	controlling	control	VBG	VBG	_	5	acl	_	_
7	CD19	cd19	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	2	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	isolated	isolate	VBD	VBD	_	2	parataxis	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	functionally	functionally	RB	RB	_	15	advmod	_	_
15	characterized	characterize	VBD	VBD	_	12	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CD19	cd19	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	12	dobj	_	_
19	using	use	VBG	VBG	_	12	dep	_	_
20	in	in	FW	FW	_	22	amod	_	_
21	vivo	vivo	FW	FW	_	20	dep	_	_
22	footprinting	footprinting	NN	NN	_	19	dobj	_	_
23	,	,	,	,	_	22	punct	_	_
24	gel	gel	NN	NN	_	26	compound	_	_
25	shift	shift	NN	NN	_	26	compound	_	_
26	assays	assay	NNS	NNS	_	22	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	transfection	transfection	NN	NN	_	30	compound	_	_
30	studies	study	NNS	NNS	_	22	conj	_	_
31	.	.	.	.	_	2	punct	_	_

1	Reporter	reporter	NN	NN	_	2	compound	_	_
2	constructs	construct	NNS	NNS	_	8	nsubj	_	_
3	spanning	span	VBG	VBG	_	2	acl	_	_
4	portions	portion	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	promoter	promoter	NN	NN	_	4	nmod	_	_
8	identified	identify	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	region	region	NN	NN	_	8	dobj	_	_
11	between	between	IN	IN	_	10	amod	_	_
12	-85	-85	CD	CD	_	10	nummod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	-200	-200	CD	CD	_	10	conj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	produced	produce	VBD	VBD	_	10	acl:relcl	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	levels	level	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	reporter	reporter	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	footprinting	footprinting	NN	NN	_	4	nsubj	_	_
4	identified	identify	VBD	VBD	_	0	root	_	_
5	protected	protected	JJ	JJ	_	6	amod	_	_
6	regions	region	NNS	NNS	_	4	dobj	_	_
7	over	over	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	known	known	JJ	JJ	_	11	amod	_	_
10	high	high	JJ	JJ	_	11	amod	_	_
11	affinity	affinity	NN	NN	_	6	nmod	_	_
12	B	b	NN	NN	_	20	compound	_	_
13	cell	cell	NN	NN	_	20	compound	_	_
14	lineage-specific	lineage-specific	JJ	JJ	_	20	amod	_	_
15	activator	activator	NN	NN	_	20	compound	_	_
16	protein	protein	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	BSAP	bsap	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	site	site	NN	NN	_	11	dep	_	_
21	,	,	,	,	_	6	punct	_	_
22	the	the	DT	DT	_	26	det	_	_
23	low	low	JJ	JJ	_	26	amod	_	_
24	affinity	affinity	NN	NN	_	26	compound	_	_
25	BSAP	bsap	NN	NN	_	26	compound	_	_
26	site	site	NN	NN	_	6	appos	_	_
27	,	,	,	,	_	26	punct	_	_
28	a	a	DT	DT	_	30	det	_	_
29	SP1/Egr-1	sp1/egr-1	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	26	conj	_	_
31	termed	term	VBN	VBN	_	30	acl	_	_
32	the	the	DT	DT	_	35	det	_	_
33	CD19	cd19	NN	NN	_	35	compound	_	_
34	GC	gc	NN	NN	_	35	compound	_	_
35	box	box	NN	NN	_	31	xcomp	_	_
36	,	,	,	,	_	26	punct	_	_
37	and	and	CC	CC	_	26	cc	_	_
38	two	two	CD	CD	_	40	nummod	_	_
39	novel	novel	JJ	JJ	_	40	amod	_	_
40	sites	site	NNS	NNS	_	26	conj	_	_
41	named	name	VBN	VBN	_	40	acl	_	_
42	the	the	DT	DT	_	44	dep	_	_
43	AT	at	NN	NN	_	44	compound	_	_
44	box	box	NN	NN	_	41	xcomp	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	PyG	pyg	NN	NN	_	47	compound	_	_
47	box	box	NN	NN	_	44	conj	_	_
48	.	.	.	.	_	4	punct	_	_

1	Phorbol	phorbol	NN	NN	_	3	compound	_	_
2	ester	ester	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	pre-B	pre-b	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	3	nmod	_	_
9	up-regulated	up-regulate	VBD	VBD	_	0	root	_	_
10	CD19	cd19	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	,	,	,	,	_	9	punct	_	_
13	induced	induce	VBD	VBD	_	9	conj	_	_
14	Egr-1	egr-1	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	enhanced	enhance	VBD	VBD	_	9	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	footprint	footprint	NN	NN	_	17	dobj	_	_
20	over	over	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	GC	gc	NN	NN	_	23	compound	_	_
23	box	box	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	SP1	sp1	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Egr-1	egr-1	NN	NN	_	5	conj	_	_
8	binding	bind	VBG	VBG	_	4	dep	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	CD19	cd19	NN	NN	_	13	compound	_	_
12	GC	gc	NN	NN	_	13	compound	_	_
13	box	box	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	while	while	IN	IN	_	19	mark	_	_
16	unknown	unknown	JJ	JJ	_	18	amod	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	19	nsubj	_	_
19	bound	bind	VBD	VBD	_	4	advcl	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	PyG	pyg	NN	NN	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	AT	at	NN	NN	_	21	conj	_	_
24	boxes	box	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	4	punct	_	_

1	Mutations	mutation	NNS	NNS	_	13	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	AT	at	NN	NN	_	5	compound	_	_
5	box	box	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	BSAP	bsap	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	5	conj	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affect	affect	VB	VB	_	0	root	_	_
14	CD19	cd19	NN	NN	_	17	compound	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	construct	construct	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	while	while	IN	IN	_	26	mark	_	_
20	a	a	DT	DT	_	21	det	_	_
21	mutation	mutation	NN	NN	_	26	nsubj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	GC	gc	NN	NN	_	25	compound	_	_
25	box	box	NN	NN	_	21	nmod	_	_
26	reduced	reduce	VBD	VBD	_	13	advcl	_	_
27	it	it	PRP	PRP	_	26	dobj	_	_
28	modestly	modestly	RB	RB	_	27	advmod	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	a	a	DT	DT	_	34	det	_	_
32	PyG	pyg	NN	NN	_	33	compound	_	_
33	box	box	NN	NN	_	34	compound	_	_
34	mutation	mutation	NN	NN	_	35	nsubj	_	_
35	reduced	reduce	VBD	VBD	_	26	conj	_	_
36	it	it	PRP	PRP	_	35	dobj	_	_
37	dramatically	dramatically	RB	RB	_	36	advmod	_	_
38	.	.	.	.	_	13	punct	_	_

1	BSAP	bsap	NN	NN	_	2	nsubj	_	_
2	failed	fail	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	trans-activate	trans-activate	VB	VB	_	2	xcomp	_	_
5	CD19	cd19	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	non-B	non-b	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	,	,	,	,	_	2	punct	_	_
15	suggesting	suggest	VBG	VBG	_	2	xcomp	_	_
16	that	that	IN	IN	_	28	mark	_	_
17	cis	cis	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	28	nsubj	_	_
19	such	such	JJ	JJ	_	22	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	PyG	pyg	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	GC	gc	NN	NN	_	22	conj	_	_
25	boxes	box	NNS	NNS	_	22	dep	_	_
26	are	be	VBP	VBP	_	28	cop	_	_
27	also	also	RB	RB	_	28	advmod	_	_
28	necessary	necessary	JJ	JJ	_	15	ccomp	_	_
29	for	for	IN	IN	_	34	case	_	_
30	high	high	JJ	JJ	_	34	amod	_	_
31	level	level	NN	NN	_	34	compound	_	_
32	CD19	cd19	NN	NN	_	33	compound	_	_
33	promoter	promoter	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	conserved	conserve	VBN	VBN	_	4	amod	_	_
3	tissue-specific	tissue-specific	JJ	JJ	_	2	dep	_	_
4	structure	structure	NN	NN	_	0	root	_	_
5	at	at	IN	IN	_	12	case	_	_
6	a	a	DT	DT	_	12	det	_	_
7	human	human	JJ	JJ	_	12	amod	_	_
8	T-cell	t-cell	NN	NN	_	12	compound	_	_
9	receptor	receptor	NN	NN	_	12	compound	_	_
10	beta-chain	beta-chain	NN	NN	_	12	compound	_	_
11	core	core	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	T-cell	t-cell	NN	NN	_	8	compound	_	_
3	receptor	receptor	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	TCR	tcr	NN	NN	_	8	compound	_	_
6	)	)	-RRB-	-RRB-	_	8	punct	_	_
7	beta-chain	beta-chain	NN	NN	_	8	compound	_	_
8	promoters	promoter	NNS	NNS	_	11	nsubjpass	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	characterized	characterize	VBN	VBN	_	0	root	_	_
12	as	as	IN	IN	_	15	case	_	_
13	nonstructured	nonstructured	JJ	JJ	_	15	amod	_	_
14	basal	basal	JJ	JJ	_	15	amod	_	_
15	promoters	promoter	NNS	NNS	_	11	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	carry	carry	VBP	VBP	_	15	acl:relcl	_	_
18	a	a	DT	DT	_	24	det	_	_
19	single	single	JJ	JJ	_	24	amod	_	_
20	conserved	conserve	VBN	VBN	_	19	dep	_	_
21	ubiquitous	ubiquitous	JJ	JJ	_	24	amod	_	_
22	cyclic	cyclic	JJ	JJ	_	24	amod	_	_
23	AMP-responsive	amp-responsive	JJ	JJ	_	24	amod	_	_
24	element	element	NN	NN	_	17	dobj	_	_
25	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	investigation	investigation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	TCR	tcr	NN	NN	_	8	compound	_	_
7	beta	beta	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	2	nmod	_	_
9	uncovers	uncover	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	15	det	_	_
11	surprisingly	surprisingly	RB	RB	_	12	advmod	_	_
12	complex	complex	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	tissue-specific	tissue-specific	JJ	JJ	_	12	conj	_	_
15	structure	structure	NN	NN	_	9	dobj	_	_
16	at	at	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	TCR	tcr	NN	NN	_	21	compound	_	_
19	Vbeta	vbeta	NN	NN	_	21	compound	_	_
20	8.1	8.1	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	core	core	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	promoter	promoter	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	positions	position	NNS	NNS	_	2	appos	_	_
8	-42	-42	CD	CD	_	7	nummod	_	_
9	to	to	TO	TO	_	7	dep	_	_
10	+11	+11	CD	CD	_	7	nummod	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	recognized	recognize	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	lymphoid	lymphoid	JJ	JJ	_	19	amod	_	_
17	cell-specific	cell-specific	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	13	nmod	_	_
20	Ets-1	ets-1	NN	NN	_	19	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	LEF1	lef1	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	AML1	aml1	NN	NN	_	20	conj	_	_
26	as	as	RB	RB	_	19	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	by	by	IN	IN	_	30	case	_	_
30	CREB/ATF-1	creb/atf-1	NN	NN	_	19	conj	_	_
31	,	,	,	,	_	13	punct	_	_
32	as	as	IN	IN	_	34	mark	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	demonstrated	demonstrate	VBN	VBN	_	13	advcl	_	_
35	in	in	IN	IN	_	37	case	_	_
36	gel	gel	NN	NN	_	37	compound	_	_
37	shift	shift	NN	NN	_	34	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	footprinting	footprinting	NN	NN	_	37	conj	_	_
40	experiments	experiment	NNS	NNS	_	37	dep	_	_
41	.	.	.	.	_	13	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	exception	exception	NN	NN	_	9	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	LEF1	lef1	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	these	these	DT	DT	_	8	det	_	_
8	factors	factor	NNS	NNS	_	9	nsubj	_	_
9	activate	activate	VBP	VBP	_	0	root	_	_
10	transcription	transcription	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Binding	bind	VBG	VBG	_	2	amod	_	_
2	sites	site	NNS	NNS	_	7	nsubj	_	_
3	at	at	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	core	core	NN	NN	_	6	compound	_	_
6	region	region	NN	NN	_	2	nmod	_	_
7	show	show	VBP	VBP	_	0	root	_	_
8	little	little	JJ	JJ	_	9	amod	_	_
9	conservation	conservation	NN	NN	_	7	dobj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	consensus	consensus	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Nonetheless	nonetheless	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	CREB	creb	NN	NN	_	9	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	Ets-1	ets-1	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	AML1	aml1	NN	NN	_	3	conj	_	_
9	bind	bind	VBP	VBP	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	activate	activate	VBP	VBP	_	9	conj	_	_
12	cooperatively	cooperatively	RB	RB	_	13	advmod	_	_
13	and	and	CC	CC	_	11	advmod	_	_
14	very	very	RB	RB	_	15	advmod	_	_
15	efficiently	efficiently	RB	RB	_	13	advmod	_	_
16	through	through	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	nonconsensus	nonconsensus	JJ	JJ	_	20	amod	_	_
19	binding	bind	VBG	VBG	_	20	amod	_	_
20	sites	site	NNS	NNS	_	9	nmod	_	_
21	at	at	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	core	core	NN	NN	_	25	compound	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	region	region	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Moderate	moderate	JJ	JJ	_	3	amod	_	_
2	ubiquitous	ubiquitous	JJ	JJ	_	1	dep	_	_
3	activation	activation	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	further	further	RB	RB	_	6	advmod	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	CREB/ATF	creb/atf	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Sp1	sp1	NN	NN	_	8	conj	_	_
11	factors	factor	NNS	NNS	_	8	dep	_	_
12	through	through	IN	IN	_	15	case	_	_
13	proximal	proximal	JJ	JJ	_	15	amod	_	_
14	upstream	upstream	JJ	JJ	_	15	amod	_	_
15	elements	element	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	tissue-specific	tissue-specific	JJ	JJ	_	5	amod	_	_
3	core	core	NN	NN	_	5	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	structure	structure	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	apparently	apparently	RB	RB	_	8	advmod	_	_
8	conserved	conserve	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	other	other	JJ	JJ	_	13	amod	_	_
11	T-cell-specifically	t-cell-specifically	RB	RB	_	13	advmod	_	_
12	expressed	express	VBN	VBN	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	8	nmod	_	_
14	such	such	JJ	JJ	_	18	case	_	_
15	as	as	IN	IN	_	14	mwe	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CD4	cd4	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	both	both	CC	CC	_	7	cc:preconj	_	_
6	the	the	DT	DT	_	7	det	_	_
7	enhancer	enhancer	NN	NN	_	11	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	10	det	_	_
10	promoter	promoter	NN	NN	_	7	conj	_	_
11	have	have	VBP	VBP	_	3	ccomp	_	_
12	a	a	DT	DT	_	15	det	_	_
13	complex	complex	JJ	JJ	_	15	amod	_	_
14	tissue-specific	tissue-specific	JJ	JJ	_	13	dep	_	_
15	structure	structure	NN	NN	_	11	dobj	_	_
16	whose	whose	WP$	WP$	_	18	nmod:poss	_	_
17	functional	functional	JJ	JJ	_	18	amod	_	_
18	interplay	interplay	NN	NN	_	19	nsubj	_	_
19	potentiates	potentiate	VBZ	VBZ	_	15	acl:relcl	_	_
20	T-cell-specific	t-cell-specific	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Opposite	opposite	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	acute	acute	JJ	JJ	_	11	amod	_	_
6	promyelocytic	promyelocytic	JJ	JJ	_	11	amod	_	_
7	leukemia	leukemia	NN	NN	_	11	compound	_	_
8	PML-retinoic	pml-retinoic	JJ	JJ	_	11	amod	_	_
9	acid	acid	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	2	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	RAR	rar	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	PLZF-RAR	plzf-rar	NN	NN	_	20	compound	_	_
18	alpha	alpha	NN	NN	_	20	compound	_	_
19	fusion	fusion	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	11	conj	_	_
21	on	on	IN	IN	_	24	case	_	_
22	retinoic	retinoic	JJ	JJ	_	24	amod	_	_
23	acid	acid	NN	NN	_	24	compound	_	_
24	signalling	signalling	NN	NN	_	2	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	Fusion	fusion	NN	NN	_	2	compound	_	_
2	proteins	protein	NNS	NNS	_	23	nsubj	_	_
3	involving	involve	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	retinoic	retinoic	JJ	JJ	_	6	amod	_	_
6	acid	acid	NN	NN	_	3	dobj	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	RAR	rar	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	6	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	PML	pml	NN	NN	_	6	conj	_	_
16	or	or	CC	CC	_	2	cc	_	_
17	PLZF	plzf	NN	NN	_	19	compound	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	protein	protein	NN	NN	_	2	conj	_	_
20	are	be	VBP	VBP	_	23	cop	_	_
21	the	the	DT	DT	_	23	det	_	_
22	genetic	genetic	JJ	JJ	_	23	amod	_	_
23	markers	marker	NNS	NNS	_	0	root	_	_
24	of	of	IN	IN	_	27	case	_	_
25	acute	acute	JJ	JJ	_	27	amod	_	_
26	promyelocytic	promyelocytic	JJ	JJ	_	27	amod	_	_
27	leukemias	leukemia	NNS	NNS	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	APLs	apl	NNS	NNS	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	23	punct	_	_

1	APLs	apl	NNS	NNS	_	14	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	PML-RAR	pml-rar	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	11	det	_	_
8	PLZF-RAR	plzf-rar	NN	NN	_	11	compound	_	_
9	alpha	alpha	NN	NN	_	11	compound	_	_
10	fusion	fusion	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	5	conj	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	phenotypically	phenotypically	RB	RB	_	14	advmod	_	_
14	indistinguishable	indistinguishable	JJ	JJ	_	0	root	_	_
15	except	except	IN	IN	_	18	mark	_	_
16	that	that	IN	IN	_	18	mark	_	_
17	they	they	PRP	PRP	_	18	nsubj	_	_
18	differ	differ	VBP	VBP	_	14	advcl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	sensitivity	sensitivity	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	29	case	_	_
23	retinoic	retinoic	JJ	JJ	_	29	amod	_	_
24	acid	acid	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	RA	ra	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	-induced	-induced	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	21	nmod	_	_
30	:	:	:	:	_	14	punct	_	_
31	PML-RAR	pml-rar	NN	NN	_	32	compound	_	_
32	alpha	alpha	NN	NN	_	33	compound	_	_
33	blasts	blast	NNS	NNS	_	35	nsubj	_	_
34	are	be	VBP	VBP	_	35	cop	_	_
35	sensitive	sensitive	JJ	JJ	_	14	parataxis	_	_
36	to	to	TO	TO	_	37	case	_	_
37	RA	ra	NN	NN	_	35	nmod	_	_
38	and	and	CC	CC	_	35	cc	_	_
39	patients	patient	NNS	NNS	_	40	nsubj	_	_
40	enter	enter	VBP	VBP	_	35	conj	_	_
41	disease	disease	NN	NN	_	42	compound	_	_
42	remission	remission	NN	NN	_	40	dobj	_	_
43	after	after	IN	IN	_	45	case	_	_
44	RA	ra	NN	NN	_	45	compound	_	_
45	treatment	treatment	NN	NN	_	40	nmod	_	_
46	,	,	,	,	_	40	punct	_	_
47	while	while	IN	IN	_	52	mark	_	_
48	patients	patient	NNS	NNS	_	52	nsubj	_	_
49	with	with	IN	IN	_	51	case	_	_
50	PLZF-RAR	plzf-rar	NN	NN	_	51	compound	_	_
51	alpha	alpha	NN	NN	_	48	nmod	_	_
52	do	do	VBP	VBP	_	40	advcl	_	_
53	not	not	RB	RB	_	52	neg	_	_
54	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	here	here	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	i	i	LS	LS	_	16	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	like	like	IN	IN	_	11	case	_	_
9	PML-RAR	pml-rar	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	16	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	PLZF-RAR	plzf-rar	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	16	nsubj	_	_
16	blocks	block	VBZ	VBZ	_	3	ccomp	_	_
17	terminal	terminal	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	hematopoietic	hematopoietic	JJ	JJ	_	23	amod	_	_
21	precursor	precursor	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	U937	u937	NN	NN	_	23	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	HL-60	hl-60	NN	NN	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	in	in	IN	IN	_	30	case	_	_
30	response	response	NN	NN	_	16	nmod	_	_
31	to	to	TO	TO	_	33	case	_	_
32	different	different	JJ	JJ	_	33	amod	_	_
33	stimuli	stimulus	NNS	NNS	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	vitamin	vitamin	NN	NN	_	36	compound	_	_
36	D3	d3	NN	NN	_	33	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	transforming	transform	VBG	VBG	_	40	amod	_	_
39	growth	growth	NN	NN	_	40	compound	_	_
40	factor	factor	NN	NN	_	36	conj	_	_
41	beta1	beta1	NN	NN	_	40	dep	_	_
42	,	,	,	,	_	36	punct	_	_
43	and	and	CC	CC	_	36	cc	_	_
44	dimethyl	dimethyl	NN	NN	_	45	compound	_	_
45	sulfoxide	sulfoxide	NN	NN	_	36	conj	_	_
46	)	)	-RRB-	-RRB-	_	36	punct	_	_
47	;	;	:	:	_	16	punct	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	ii	ii	LS	LS	_	59	dep	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	PML-RAR	pml-rar	NN	NN	_	52	compound	_	_
52	alpha	alpha	NN	NN	_	59	nsubj	_	_
53	,	,	,	,	_	52	punct	_	_
54	but	but	CC	CC	_	55	cc	_	_
55	not	not	RB	RB	_	52	cc	_	_
56	PLZF-RAR	plzf-rar	NN	NN	_	57	compound	_	_
57	alpha	alpha	NN	NN	_	52	conj	_	_
58	,	,	,	,	_	52	punct	_	_
59	increases	increase	VBZ	VBZ	_	16	conj	_	_
60	RA	ra	NN	NN	_	61	compound	_	_
61	sensitivity	sensitivity	NN	NN	_	59	dobj	_	_
62	of	of	IN	IN	_	65	case	_	_
63	hematopoietic	hematopoietic	JJ	JJ	_	65	amod	_	_
64	precursor	precursor	NN	NN	_	65	compound	_	_
65	cells	cell	NNS	NNS	_	61	nmod	_	_
66	and	and	CC	CC	_	59	cc	_	_
67	restores	restore	VBZ	VBZ	_	59	conj	_	_
68	RA	ra	NN	NN	_	69	compound	_	_
69	sensitivity	sensitivity	NN	NN	_	67	dobj	_	_
70	of	of	IN	IN	_	73	case	_	_
71	RA-resistant	ra-resistant	JJ	JJ	_	73	amod	_	_
72	hematopoietic	hematopoietic	JJ	JJ	_	73	amod	_	_
73	cells	cell	NNS	NNS	_	69	nmod	_	_
74	;	;	:	:	_	16	punct	_	_
75	(	(	-LRB-	-LRB-	_	76	punct	_	_
76	iii	iii	LS	LS	_	83	dep	_	_
77	)	)	-RRB-	-RRB-	_	76	punct	_	_
78	PML-RAR	pml-rar	NN	NN	_	79	compound	_	_
79	alpha	alpha	NN	NN	_	83	nsubj	_	_
80	and	and	CC	CC	_	79	cc	_	_
81	PLZF-RAR	plzf-rar	NN	NN	_	82	compound	_	_
82	alpha	alpha	NN	NN	_	79	conj	_	_
83	have	have	VBP	VBP	_	16	conj	_	_
84	similar	similar	JJ	JJ	_	87	amod	_	_
85	RA	ra	NN	NN	_	87	compound	_	_
86	binding	binding	NN	NN	_	87	compound	_	_
87	affinities	affinity	NNS	NNS	_	83	dobj	_	_
88	;	;	:	:	_	16	punct	_	_
89	and	and	CC	CC	_	16	cc	_	_
90	(	(	-LRB-	-LRB-	_	91	punct	_	_
91	iv	iv	LS	LS	_	95	dep	_	_
92	)	)	-RRB-	-RRB-	_	91	punct	_	_
93	PML-RAR	pml-rar	NN	NN	_	94	compound	_	_
94	alpha	alpha	NN	NN	_	95	nsubj	_	_
95	enhances	enhance	VBZ	VBZ	_	16	conj	_	_
96	the	the	DT	DT	_	98	det	_	_
97	RA	ra	NN	NN	_	98	compound	_	_
98	response	response	NN	NN	_	95	dobj	_	_
99	of	of	IN	IN	_	102	case	_	_
100	RA	ra	NN	NN	_	102	compound	_	_
101	target	target	NN	NN	_	102	compound	_	_
102	genes	gene	NNS	NNS	_	98	nmod	_	_
103	(	(	-LRB-	-LRB-	_	104	punct	_	_
104	those	those	DT	DT	_	98	dep	_	_
105	for	for	IN	IN	_	107	case	_	_
106	RAR	rar	NN	NN	_	107	compound	_	_
107	beta	beta	NN	NN	_	104	nmod	_	_
108	,	,	,	,	_	107	punct	_	_
109	RAR	rar	NN	NN	_	110	compound	_	_
110	gamma	gamma	NN	NN	_	107	conj	_	_
111	,	,	,	,	_	107	punct	_	_
112	and	and	CC	CC	_	107	cc	_	_
113	transglutaminase	transglutaminase	NN	NN	_	114	compound	_	_
114	type	type	NN	NN	_	107	conj	_	_
115	II	ii	CD	CD	_	114	nummod	_	_
116	-LSB-	-lsb-	-LRB-	-LRB-	_	117	punct	_	_
117	TGase	tgase	NN	NN	_	114	appos	_	_
118	-RSB-	-rsb-	-RRB-	-RRB-	_	117	punct	_	_
119	)	)	-RRB-	-RRB-	_	104	punct	_	_
120	in	in	FW	FW	_	121	compound	_	_
121	vivo	vivo	FW	FW	_	95	advmod	_	_
122	,	,	,	,	_	95	punct	_	_
123	while	while	IN	IN	_	127	mark	_	_
124	PLZF-RAR	plzf-rar	NN	NN	_	125	compound	_	_
125	alpha	alpha	NN	NN	_	126	compound	_	_
126	expression	expression	NN	NN	_	127	nsubj	_	_
127	has	have	VBZ	VBZ	_	95	advcl	_	_
128	either	either	CC	CC	_	130	cc:preconj	_	_
129	no	no	DT	DT	_	130	neg	_	_
130	effect	effect	NN	NN	_	127	dobj	_	_
131	(	(	-LRB-	-LRB-	_	133	punct	_	_
132	RAR	rar	NN	NN	_	133	compound	_	_
133	beta	beta	NN	NN	_	130	appos	_	_
134	)	)	-RRB-	-RRB-	_	133	punct	_	_
135	or	or	CC	CC	_	130	cc	_	_
136	an	a	DT	DT	_	138	det	_	_
137	inhibitory	inhibitory	JJ	JJ	_	138	amod	_	_
138	activity	activity	NN	NN	_	130	conj	_	_
139	(	(	-LRB-	-LRB-	_	141	punct	_	_
140	RAR	rar	NN	NN	_	141	compound	_	_
141	gamma	gamma	NN	NN	_	138	dep	_	_
142	and	and	CC	CC	_	141	cc	_	_
143	type	type	NN	NN	_	145	compound	_	_
144	II	ii	CD	CD	_	145	nummod	_	_
145	TGase	tgase	NN	NN	_	141	conj	_	_
146	)	)	-RRB-	-RRB-	_	141	punct	_	_
147	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	PML-RAR	pml-rar	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	PLZF-RAR	plzf-rar	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	6	conj	_	_
10	have	have	VBP	VBP	_	3	ccomp	_	_
11	similar	similar	JJ	JJ	_	15	amod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	inhibitory	inhibitory	JJ	JJ	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	effects	effect	NNS	NNS	_	10	dobj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	RA-independent	ra-independent	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	opposite	opposite	JJ	JJ	_	26	amod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	stimulatory	stimulatory	JJ	JJ	_	20	dep	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	inhibitory	inhibitory	JJ	JJ	_	22	conj	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	effects	effect	NNS	NNS	_	15	conj	_	_
27	on	on	IN	IN	_	29	case	_	_
28	RA-dependent	ra-dependent	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	10	cc	_	_
31	that	that	IN	IN	_	33	mark	_	_
32	they	they	PRP	PRP	_	33	nsubj	_	_
33	behave	behave	VBP	VBP	_	10	conj	_	_
34	in	in	FW	FW	_	35	compound	_	_
35	vivo	vivo	FW	FW	_	33	advmod	_	_
36	as	as	IN	IN	_	38	case	_	_
37	RA-dependent	ra-dependent	JJ	JJ	_	38	amod	_	_
38	enhancers	enhancer	NNS	NNS	_	33	nmod	_	_
39	or	or	CC	CC	_	38	cc	_	_
40	inhibitors	inhibitor	NNS	NNS	_	38	conj	_	_
41	of	of	IN	IN	_	43	case	_	_
42	RA-responsive	ra-responsive	JJ	JJ	_	43	amod	_	_
43	genes	gene	NNS	NNS	_	40	nmod	_	_
44	,	,	,	,	_	33	punct	_	_
45	respectively	respectively	RB	RB	_	33	advmod	_	_
46	.	.	.	.	_	3	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	activities	activity	NNS	NNS	_	10	nsubj	_	_
4	on	on	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	RA	ra	NN	NN	_	8	compound	_	_
7	signalling	signalling	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	3	nmod	_	_
9	might	might	MD	MD	_	10	aux	_	_
10	underlie	underlie	VB	VB	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	different	different	JJ	JJ	_	13	amod	_	_
13	responses	response	NNS	NNS	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	PML-RAR	pml-rar	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	PLZF-RAR	plzf-rar	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	16	conj	_	_
20	APLs	apl	NNS	NNS	_	16	dep	_	_
21	to	to	TO	TO	_	23	case	_	_
22	RA	ra	NN	NN	_	23	compound	_	_
23	treatment	treatment	NN	NN	_	13	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	PLZF-RAR	plzf-rar	NN	NN	_	5	compound	_	_
3	alpha	alpha	NN	NN	_	5	compound	_	_
4	fusion	fusion	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	6	nsubj	_	_
6	contains	contain	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	11	det	_	_
8	approximately	approximately	RB	RB	_	11	advmod	_	_
9	120-amino-acid	120-amino-acid	JJ	JJ	_	11	amod	_	_
10	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
11	motif	motif	NN	NN	_	6	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	called	call	VBN	VBN	_	11	dep	_	_
14	the	the	DT	DT	_	16	det	_	_
15	POZ	poz	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	13	xcomp	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	,	,	,	,	_	11	punct	_	_
19	which	which	WDT	WDT	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	found	find	VBN	VBN	_	11	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	variety	variety	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	zinc	zinc	NN	NN	_	29	compound	_	_
28	finger	finger	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	25	nmod	_	_
30	and	and	CC	CC	_	25	cc	_	_
31	a	a	DT	DT	_	32	det	_	_
32	group	group	NN	NN	_	25	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	poxvirus	poxvirus	NN	NN	_	35	compound	_	_
35	proteins	protein	NNS	NNS	_	32	nmod	_	_
36	and	and	CC	CC	_	22	cc	_	_
37	which	which	WDT	WDT	_	38	nsubj	_	_
38	mediates	mediate	VBZ	VBZ	_	22	conj	_	_
39	protein-protein	protein-protein	JJ	JJ	_	40	amod	_	_
40	interactions	interaction	NNS	NNS	_	38	dobj	_	_
41	.	.	.	.	_	6	punct	_	_

1	Deletion	deletion	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	PLZF	plzf	NN	NN	_	6	compound	_	_
5	POZ	poz	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	1	nmod	_	_
7	partially	partially	RB	RB	_	8	advmod	_	_
8	abrogated	abrogate	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	PLZF-RAR	plzf-rar	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	RA-induced	ra-induced	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	on	on	IN	IN	_	24	case	_	_
20	RA-mediated	ra-mediated	JJ	JJ	_	24	amod	_	_
21	type	type	NN	NN	_	23	compound	_	_
22	II	ii	CD	CD	_	23	nummod	_	_
23	TGase	tgase	NN	NN	_	24	compound	_	_
24	up-regulation	up-regulation	NN	NN	_	17	conj	_	_
25	,	,	,	,	_	8	punct	_	_
26	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
27	that	that	IN	IN	_	33	mark	_	_
28	POZ-mediated	poz-mediated	JJ	JJ	_	30	amod	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	interactions	interaction	NNS	NNS	_	33	nsubj	_	_
31	might	might	MD	MD	_	33	aux	_	_
32	be	be	VB	VB	_	33	cop	_	_
33	responsible	responsible	JJ	JJ	_	26	ccomp	_	_
34	for	for	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	inhibitory	inhibitory	JJ	JJ	_	38	amod	_	_
37	transcriptional	transcriptional	JJ	JJ	_	36	dep	_	_
38	activities	activity	NNS	NNS	_	33	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	PLZF-RAR	plzf-rar	NN	NN	_	41	compound	_	_
41	alpha	alpha	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	8	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	human	human	JJ	JJ	_	8	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
5	virus	virus	NN	NN	_	8	compound	_	_
6	type	type	NN	NN	_	8	compound	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	monocytic	monocytic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	Cryptococcus	cryptococcus	FW	FW	_	14	compound	_	_
14	neoformans	neoformans	FW	FW	_	1	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	Candida	candida	FW	FW	_	17	compound	_	_
17	albicans	albicans	FW	FW	_	14	conj	_	_
18	.	.	.	.	_	1	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	candidiasis	candidiasis	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cryptococcosis	cryptococcosis	NN	NN	_	2	conj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	common	common	JJ	JJ	_	32	advcl	_	_
7	in	in	IN	IN	_	15	case	_	_
8	human	human	JJ	JJ	_	14	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	14	nmod:npmod	_	_
10	virus	virus	NN	NN	_	14	nmod:npmod	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	HIV	hiv	NN	NN	_	14	nmod:npmod	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	-infected	-infected	JJ	JJ	_	15	amod	_	_
15	persons	person	NNS	NNS	_	6	nmod	_	_
16	,	,	,	,	_	32	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	32	nsubjpass	_	_
19	of	of	IN	IN	_	21	case	_	_
20	Cryptococcus	cryptococcus	FW	FW	_	21	compound	_	_
21	neoformans	neoformans	FW	FW	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Candida	candida	FW	FW	_	24	compound	_	_
24	albicans	albicans	FW	FW	_	21	conj	_	_
25	on	on	IN	IN	_	27	case	_	_
26	HIV	hiv	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	18	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	monocytic	monocytic	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	examined	examine	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	Stimulation	stimulation	NN	NN	_	23	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	latently	latently	RB	RB	_	8	advmod	_	_
5	HIV-infected	hiv-infected	JJ	JJ	_	8	amod	_	_
6	myelomonocytic	myelomonocytic	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	1	nmod	_	_
9	OM-10.1	om-10.1	NN	NN	_	8	dep	_	_
10	with	with	IN	IN	_	12	case	_	_
11	C.	c.	FW	FW	_	12	compound	_	_
12	neoformans	neoformans	FW	FW	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	C.	c.	FW	FW	_	15	compound	_	_
15	albicans	albicans	FW	FW	_	12	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	presence	presence	NN	NN	_	1	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	pooled	pooled	JJ	JJ	_	22	amod	_	_
21	human	human	JJ	JJ	_	20	dep	_	_
22	serum	serum	NN	NN	_	18	nmod	_	_
23	caused	cause	VBD	VBD	_	0	root	_	_
24	a	a	DT	DT	_	26	det	_	_
25	ratio-dependent	ratio-dependent	JJ	JJ	_	26	amod	_	_
26	increase	increase	NN	NN	_	23	dobj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	HIV	hiv	NN	NN	_	29	compound	_	_
29	production	production	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	Induction	induction	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HIV	hiv	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	C.	c.	FW	FW	_	6	compound	_	_
6	neoformans	neoformans	FW	FW	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	enhanced	enhance	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	anti-capsular	anti-capsular	JJ	JJ	_	11	amod	_	_
11	antibody	antibody	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	while	while	IN	IN	_	19	mark	_	_
14	induction	induction	NN	NN	_	19	nsubjpass	_	_
15	by	by	IN	IN	_	17	case	_	_
16	both	both	DT	DT	_	17	det	_	_
17	organisms	organism	NNS	NNS	_	14	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	inhibited	inhibit	VBN	VBN	_	8	advcl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	anti-TNF-alpha	anti-tnf-alpha	JJ	JJ	_	22	amod	_	_
22	antibody	antibody	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	THP-1	thp-1	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	12	nmod	_	_
4	transfected	transfect	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	8	case	_	_
6	HIV	hiv	NN	NN	_	8	compound	_	_
7	plasmid	plasmid	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	both	both	DT	DT	_	11	det	_	_
11	organisms	organism	NNS	NNS	_	12	nsubj	_	_
12	induced	induce	VBD	VBD	_	0	root	_	_
13	transcription	transcription	NN	NN	_	12	dobj	_	_
14	from	from	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	HIV	hiv	NN	NN	_	19	compound	_	_
17	long	long	JJ	JJ	_	19	amod	_	_
18	terminal	terminal	JJ	JJ	_	19	amod	_	_
19	repeat	repeat	NN	NN	_	12	nmod	_	_
20	that	that	WDT	WDT	_	22	nsubj	_	_
21	was	be	VBD	VBD	_	22	cop	_	_
22	dependent	dependent	JJ	JJ	_	19	acl:relcl	_	_
23	on	on	IN	IN	_	27	case	_	_
24	intact	intact	JJ	JJ	_	27	amod	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	sequences	sequence	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	C.	c.	FW	FW	_	4	compound	_	_
4	neoformans	neoformans	FW	FW	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	C.	c.	FW	FW	_	7	compound	_	_
7	albicans	albicans	FW	FW	_	4	conj	_	_
8	enhance	enhance	VBP	VBP	_	0	root	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	through	through	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	TNF-alpha-	tnf-alpha-	NN	NN	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	16	conj	_	_
19	mechanism	mechanism	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	HIV-infected	hiv-infected	JJ	JJ	_	3	amod	_	_
3	patients	patient	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	such	such	JJ	JJ	_	6	amod	_	_
6	enhancement	enhancement	NN	NN	_	9	nsubj	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	further	further	RB	RB	_	9	advmod	_	_
9	impair	impair	VB	VB	_	0	root	_	_
10	host	host	NN	NN	_	11	compound	_	_
11	immunity	immunity	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	could	could	MD	MD	_	14	aux	_	_
14	accelerate	accelerate	VB	VB	_	9	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	course	course	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	disease	disease	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	homologue	homologue	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	Drosophila	drosophila	FW	FW	_	8	compound	_	_
7	Toll	toll	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	3	nmod	_	_
9	signals	signal	VBZ	VBZ	_	0	root	_	_
10	activation	activation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	adaptive	adaptive	JJ	JJ	_	13	amod	_	_
13	immunity	immunity	NN	NN	_	10	nmod	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	see	see	VB	VB	_	9	parataxis	_	_
16	comments	comment	NNS	NNS	_	15	dobj	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_

1	Induction	induction	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	adaptive	adaptive	JJ	JJ	_	6	amod	_	_
5	immune	immune	JJ	JJ	_	6	amod	_	_
6	response	response	NN	NN	_	1	nmod	_	_
7	depends	depend	VBZ	VBZ	_	0	root	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	co-stimulatory	co-stimulatory	JJ	JJ	_	13	amod	_	_
13	molecules	molecule	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cytokines	cytokine	NNS	NNS	_	13	conj	_	_
16	by	by	IN	IN	_	18	case	_	_
17	antigen-presenting	antigen-presenting	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	15	nsubjpass	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	control	control	VBP	VBP	_	2	acl:relcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	initial	initial	JJ	JJ	_	7	amod	_	_
7	induction	induction	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	signals	signal	NNS	NNS	_	7	nmod	_	_
11	upon	upon	IN	IN	_	12	case	_	_
12	infection	infection	NN	NN	_	7	nmod	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	poorly	poorly	RB	RB	_	15	advmod	_	_
15	understood	understand	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	proposed	propose	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	their	they	PRP$	PRP$	_	7	nmod:poss	_	_
7	expression	expression	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	controlled	control	VBN	VBN	_	4	ccomp	_	_
10	by	by	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	non-clonal	non-clonal	JJ	JJ	_	17	amod	_	_
13	,	,	,	,	_	12	punct	_	_
14	or	or	CC	CC	_	12	cc	_	_
15	innate	innate	JJ	JJ	_	12	conj	_	_
16	,	,	,	,	_	17	punct	_	_
17	component	component	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	immunity	immunity	NN	NN	_	17	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	preceded	precede	VBD	VBD	_	17	acl:relcl	_	_
22	in	in	IN	IN	_	23	case	_	_
23	evolution	evolution	NN	NN	_	21	nmod	_	_
24	the	the	DT	DT	_	25	det	_	_
25	development	development	NN	NN	_	21	dobj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	an	a	DT	DT	_	30	det	_	_
28	adaptive	adaptive	JJ	JJ	_	30	amod	_	_
29	immune	immune	JJ	JJ	_	30	amod	_	_
30	system	system	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	vertebrates	vertebrate	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	cloning	cloning	NN	NN	_	2	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	characterization	characterization	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	homologue	homologue	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	Drosophila	drosophila	FW	FW	_	16	compound	_	_
15	toll	toll	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Toll	toll	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	which	which	WDT	WDT	_	23	nsubjpass	_	_
21	has	have	VBZ	VBZ	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	shown	show	VBN	VBN	_	16	acl:relcl	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	induce	induce	VB	VB	_	23	xcomp	_	_
26	the	the	DT	DT	_	29	det	_	_
27	innate	innate	JJ	JJ	_	29	amod	_	_
28	immune	immune	JJ	JJ	_	29	amod	_	_
29	response	response	NN	NN	_	25	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	adult	adult	JJ	JJ	_	32	amod	_	_
32	Drosophila	drosophila	FW	FW	_	25	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Like	like	IN	IN	_	3	case	_	_
2	Drosophila	drosophila	FW	FW	_	3	dep	_	_
3	Toll	toll	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	Toll	toll	NN	NN	_	12	nsubj	_	_
7	is	be	VBZ	VBZ	_	12	cop	_	_
8	a	a	DT	DT	_	12	det	_	_
9	type	type	NN	NN	_	12	compound	_	_
10	I	i	CD	CD	_	12	nummod	_	_
11	transmembrane	transmembrane	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	0	root	_	_
13	with	with	IN	IN	_	16	case	_	_
14	an	a	DT	DT	_	16	det	_	_
15	extracellular	extracellular	JJ	JJ	_	16	amod	_	_
16	domain	domain	NN	NN	_	12	nmod	_	_
17	consisting	consist	VBG	VBG	_	16	acl	_	_
18	of	of	IN	IN	_	25	case	_	_
19	a	a	DT	DT	_	25	det	_	_
20	leucine-rich	leucine-rich	JJ	JJ	_	25	amod	_	_
21	repeat	repeat	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	LRR	lrr	NN	NN	_	25	compound	_	_
24	)	)	-RRB-	-RRB-	_	25	punct	_	_
25	domain	domain	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	16	punct	_	_
27	and	and	CC	CC	_	16	cc	_	_
28	a	a	DT	DT	_	30	det	_	_
29	cytoplasmic	cytoplasmic	JJ	JJ	_	30	amod	_	_
30	domain	domain	NN	NN	_	16	conj	_	_
31	homologous	homologous	JJ	JJ	_	30	amod	_	_
32	to	to	TO	TO	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	cytoplasmic	cytoplasmic	JJ	JJ	_	35	amod	_	_
35	domain	domain	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	44	case	_	_
37	the	the	DT	DT	_	44	det	_	_
38	human	human	JJ	JJ	_	44	amod	_	_
39	interleukin	interleukin	NN	NN	_	44	compound	_	_
40	(	(	-LRB-	-LRB-	_	44	punct	_	_
41	IL	il	NN	NN	_	44	compound	_	_
42	)	)	-RRB-	-RRB-	_	44	punct	_	_
43	-1	-1	CD	CD	_	44	nummod	_	_
44	receptor	receptor	NN	NN	_	35	nmod	_	_
45	.	.	.	.	_	12	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	Drosophila	drosophila	FW	FW	_	3	dep	_	_
3	Toll	toll	NN	NN	_	9	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-1	il-1	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	3	conj	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	known	know	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	signal	signal	VB	VB	_	9	xcomp	_	_
12	through	through	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
15	pathway	pathway	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	a	a	DT	DT	_	7	det	_	_
5	constitutively	constitutively	RB	RB	_	6	advmod	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	mutant	mutant	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	Toll	toll	NN	NN	_	7	nmod	_	_
11	transfected	transfect	VBN	VBN	_	7	acl	_	_
12	into	into	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	11	nmod	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	induce	induce	VB	VB	_	2	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	19	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NF-kappaB-controlled	nf-kappab-controlled	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	for	for	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	inflammatory	inflammatory	JJ	JJ	_	31	amod	_	_
31	cytokines	cytokine	NNS	NNS	_	24	nmod	_	_
32	IL-1	il-1	NN	NN	_	31	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	IL-6	il-6	NN	NN	_	32	conj	_	_
35	and	and	CC	CC	_	32	cc	_	_
36	IL-8	il-8	NN	NN	_	32	conj	_	_
37	,	,	,	,	_	19	punct	_	_
38	as	as	RB	RB	_	19	cc	_	_
39	well	well	RB	RB	_	38	mwe	_	_
40	as	as	IN	IN	_	38	mwe	_	_
41	the	the	DT	DT	_	42	det	_	_
42	expression	expression	NN	NN	_	19	conj	_	_
43	of	of	IN	IN	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	co-stimulatory	co-stimulatory	JJ	JJ	_	46	amod	_	_
46	molecule	molecule	NN	NN	_	42	nmod	_	_
47	B7.1	b7.1	NN	NN	_	46	dep	_	_
48	,	,	,	,	_	46	punct	_	_
49	which	which	WDT	WDT	_	51	nsubjpass	_	_
50	is	be	VBZ	VBZ	_	51	auxpass	_	_
51	required	require	VBN	VBN	_	46	acl:relcl	_	_
52	for	for	IN	IN	_	54	case	_	_
53	the	the	DT	DT	_	54	det	_	_
54	activation	activation	NN	NN	_	51	nmod	_	_
55	of	of	IN	IN	_	58	case	_	_
56	naive	naive	JJ	JJ	_	58	amod	_	_
57	T	t	NN	NN	_	58	compound	_	_
58	cells	cell	NNS	NNS	_	54	nmod	_	_
59	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	B-cell	b-cell	NN	NN	_	4	compound	_	_
4	commitment	commitment	NN	NN	_	1	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	plasma	plasma	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	to	to	TO	TO	_	12	case	_	_
10	memory	memory	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	conj	_	_
13	.	.	.	.	_	1	punct	_	_

1	During	during	IN	IN	_	4	case	_	_
2	humoral	humoral	JJ	JJ	_	4	amod	_	_
3	immune	immune	JJ	JJ	_	4	amod	_	_
4	responses	response	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	B-lymphocyte	b-lymphocyte	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	followed	follow	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	differentiation	differentiation	NN	NN	_	9	nmod	_	_
12	along	along	IN	IN	_	17	case	_	_
13	either	either	CC	CC	_	17	cc:preconj	_	_
14	the	the	DT	DT	_	17	det	_	_
15	plasma	plasma	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	11	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	memory	memory	NN	NN	_	22	compound	_	_
21	B-cell	b-cell	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	17	conj	_	_
23	.	.	.	.	_	9	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	CD40-CD40	cd40-cd40	JJ	JJ	_	6	amod	_	_
6	ligand	ligand	NN	NN	_	21	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	OX-OX40	ox-ox40	JJ	JJ	_	9	amod	_	_
9	ligand	ligand	NN	NN	_	6	appos	_	_
10	,	,	,	,	_	6	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	group	group	NN	NN	_	6	appos	_	_
13	of	of	IN	IN	_	14	case	_	_
14	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	factors	factor	NNS	NNS	_	14	conj	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	all	all	DT	DT	_	21	advmod	_	_
21	contribute	contribute	VB	VB	_	3	ccomp	_	_
22	to	to	TO	TO	_	25	case	_	_
23	B-lymphocyte	b-lymphocyte	NN	NN	_	25	compound	_	_
24	differentiation	differentiation	NN	NN	_	25	compound	_	_
25	control	control	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	shortened	shorten	VBN	VBN	_	4	amod	_	_
3	life	life	NN	NN	_	4	compound	_	_
4	span	span	NN	NN	_	19	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	EKLF-/-	eklf-/-	JJ	JJ	_	8	amod	_	_
7	adult	adult	JJ	JJ	_	8	amod	_	_
8	erythrocytes	erythrocyte	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	due	due	JJ	JJ	_	4	amod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	deficiency	deficiency	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	beta-globin	beta-globin	NN	NN	_	16	compound	_	_
16	chains	chain	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	ameliorated	ameliorate	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	gamma-globin	gamma-globin	NN	NN	_	23	compound	_	_
23	chains	chain	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	homologous	homologous	JJ	JJ	_	3	amod	_	_
3	recombination	recombination	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	1	punct	_	_
5	both	both	DT	DT	_	7	dep	_	_
6	EKLF	eklf	NN	NN	_	7	compound	_	_
7	alleles	allele	NNS	NNS	_	17	nsubjpass	_	_
8	in	in	IN	IN	_	15	case	_	_
9	murine	murine	JJ	JJ	_	15	amod	_	_
10	embryonic	embryonic	JJ	JJ	_	15	amod	_	_
11	stem	stem	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	ES	es	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	inactivated	inactivate	VBN	VBN	_	1	parataxis	_	_
18	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	EKLF-/-	eklf-/-	JJ	JJ	_	4	amod	_	_
3	ES	es	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	capable	capable	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	8	mark	_	_
8	undergoing	undergo	VBG	VBG	_	6	advcl	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	differentiation	differentiation	NN	NN	_	8	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	form	form	VB	VB	_	8	advcl	_	_
14	definitive	definitive	JJ	JJ	_	16	amod	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	colonies	colony	NNS	NNS	_	13	dobj	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	similar	similar	JJ	JJ	_	16	acl:relcl	_	_
20	in	in	IN	IN	_	21	case	_	_
21	size	size	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	number	number	NN	NN	_	21	conj	_	_
24	to	to	TO	TO	_	25	case	_	_
25	those	those	DT	DT	_	19	nmod	_	_
26	formed	form	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	30	case	_	_
28	wild-type	wild-type	JJ	JJ	_	30	amod	_	_
29	ES	es	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	EKLF-/-	eklf-/-	JJ	JJ	_	5	amod	_	_
5	colonies	colony	NNS	NNS	_	8	nsubjpass	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	poorly	poorly	RB	RB	_	8	advmod	_	_
8	hemoglobinized	hemoglobinize	VBN	VBN	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	enucleated	enucleate	VBN	VBN	_	11	amod	_	_
11	erythrocytes	erythrocyte	NNS	NNS	_	15	nsubj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	colonies	colony	NNS	NNS	_	11	nmod	_	_
15	contained	contain	VBD	VBD	_	8	conj	_	_
16	numerous	numerous	JJ	JJ	_	18	amod	_	_
17	Heinz	heinz	NN	NN	_	18	compound	_	_
18	bodies	body	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	8	punct	_	_

1	Reverse	reverse	JJ	JJ	_	4	amod	_	_
2	transcriptase-polymerase	transcriptase-polymerase	NN	NN	_	4	compound	_	_
3	chain	chain	NN	NN	_	4	compound	_	_
4	reaction	reaction	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	RT-PCR	rt-pcr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	analyses	analysis	NNS	NNS	_	9	nsubj	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	adult	adult	JJ	JJ	_	18	nsubjpass	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	embryonic	embryonic	JJ	JJ	_	15	amod	_	_
14	globin	globin	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	11	conj	_	_
16	were	be	VBD	VBD	_	18	auxpass	_	_
17	appropriately	appropriately	RB	RB	_	18	advmod	_	_
18	regulated	regulate	VBN	VBN	_	9	ccomp	_	_
19	,	,	,	,	_	18	punct	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	exception	exception	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	beta	beta	NN	NN	_	25	compound	_	_
25	h1-globin	h1-globin	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	continued	continue	VBD	VBD	_	25	acl:relcl	_	_
29	to	to	TO	TO	_	31	mark	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	expressed	express	VBN	VBN	_	28	xcomp	_	_
32	at	at	IN	IN	_	36	case	_	_
33	a	a	DT	DT	_	36	det	_	_
34	very	very	RB	RB	_	35	advmod	_	_
35	low	low	JJ	JJ	_	36	amod	_	_
36	level	level	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ratio	ratio	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	adult	adult	JJ	JJ	_	6	amod	_	_
5	beta-globin/alpha-globin	beta-globin/alpha-globin	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	mutant	mutant	JJ	JJ	_	11	amod	_	_
10	ES	es	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	1/15	1/15	CD	CD	_	0	root	_	_
14	of	of	IN	IN	_	15	case	_	_
15	that	that	DT	DT	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	wild-type	wild-type	JJ	JJ	_	19	amod	_	_
18	ES	es	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	EKLF-/-	eklf-/-	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	injected	inject	VBN	VBN	_	13	advcl	_	_
7	into	into	IN	IN	_	8	case	_	_
8	blastocysts	blastocyst	NNS	NNS	_	6	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	they	they	PRP	PRP	_	13	nsubj	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	contribute	contribute	VB	VB	_	0	root	_	_
14	at	at	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	detectable	detectable	JJ	JJ	_	17	amod	_	_
17	level	level	NN	NN	_	13	nmod	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	mature	mature	JJ	JJ	_	22	amod	_	_
21	erythrocyte	erythrocyte	NN	NN	_	22	compound	_	_
22	compartment	compartment	NN	NN	_	13	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	chimeric	chimeric	JJ	JJ	_	26	amod	_	_
26	animals	animal	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	13	punct	_	_
28	based	base	VBN	VBN	_	30	case	_	_
29	on	on	IN	IN	_	30	case	_	_
30	analysis	analysis	NN	NN	_	13	advcl	_	_
31	of	of	IN	IN	_	38	case	_	_
32	glucose	glucose	NN	NN	_	38	compound	_	_
33	phosphate	phosphate	NN	NN	_	38	compound	_	_
34	isomerase-1	isomerase-1	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	38	punct	_	_
36	GPI-1	gpi-1	NN	NN	_	38	compound	_	_
37	)	)	-RRB-	-RRB-	_	38	punct	_	_
38	isozymes	isozyme	NNS	NNS	_	30	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	hemoglobins	hemoglobin	NNS	NNS	_	38	conj	_	_
41	that	that	WDT	WDT	_	42	nsubj	_	_
42	distinguish	distinguish	VBP	VBP	_	38	acl:relcl	_	_
43	ES	es	NN	NN	_	45	compound	_	_
44	cell-derived	cell-derived	JJ	JJ	_	45	amod	_	_
45	erythrocytes	erythrocyte	NNS	NNS	_	42	dobj	_	_
46	from	from	IN	IN	_	47	case	_	_
47	host	host	NN	NN	_	42	nmod	_	_
48	blastocyst-derived	blastocyst-derived	JJ	JJ	_	49	amod	_	_
49	erythrocytes	erythrocyte	NNS	NNS	_	47	dep	_	_
50	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	semiquantitative	semiquantitative	JJ	JJ	_	6	amod	_	_
5	RT-PCR	rt-pcr	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	RNA	rna	NN	NN	_	6	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	reticulocytes	reticulocyte	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	same	same	JJ	JJ	_	15	amod	_	_
14	chimeric	chimeric	JJ	JJ	_	15	amod	_	_
15	animals	animal	NNS	NNS	_	10	nmod	_	_
16	suggested	suggest	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	the	the	DT	DT	_	21	det	_	_
19	ES	es	NN	NN	_	21	compound	_	_
20	cell-derived	cell-derived	JJ	JJ	_	21	amod	_	_
21	reticulocytes	reticulocyte	NNS	NNS	_	23	nsubj	_	_
22	were	be	VBD	VBD	_	23	cop	_	_
23	present	present	JJ	JJ	_	16	ccomp	_	_
24	at	at	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	level	level	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	6	6	CD	CD	_	29	nummod	_	_
29	%	%	NN	NN	_	26	nmod	_	_
30	to	to	TO	TO	_	32	case	_	_
31	8	8	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicated	indicate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	EKLF-/-	eklf-/-	JJ	JJ	_	6	amod	_	_
6	erythrocytes	erythrocyte	NNS	NNS	_	12	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	adult	adult	JJ	JJ	_	9	amod	_	_
9	animals	animal	NNS	NNS	_	6	nmod	_	_
10	must	must	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	short-lived	short-lived	JJ	JJ	_	2	ccomp	_	_
13	,	,	,	,	_	12	punct	_	_
14	apparently	apparently	RB	RB	_	15	advmod	_	_
15	due	due	JJ	JJ	_	12	advmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	imbalance	imbalance	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	beta-	beta-	NN	NN	_	18	nmod	_	_
21	versus	versus	CC	CC	_	20	cc	_	_
22	alpha-globin	alpha-globin	NN	NN	_	20	conj	_	_
23	chains	chain	NNS	NNS	_	20	dep	_	_
24	,	,	,	,	_	18	punct	_	_
25	leading	lead	VBG	VBG	_	18	dep	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	precipitation	precipitation	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	excess	excess	JJ	JJ	_	32	amod	_	_
31	alpha-globin	alpha-globin	NN	NN	_	32	compound	_	_
32	chains	chain	NNS	NNS	_	28	nmod	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	form	form	VB	VB	_	28	acl	_	_
35	Heinz	heinz	NN	NN	_	36	compound	_	_
36	bodies	body	NNS	NNS	_	34	dobj	_	_
37	.	.	.	.	_	2	punct	_	_

1	Consistent	consistent	JJ	JJ	_	11	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	the	the	DT	DT	_	9	det	_	_
7	short	short	JJ	JJ	_	9	amod	_	_
8	life	life	NN	NN	_	9	compound	_	_
9	span	span	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	ameliorated	ameliorate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	introduction	introduction	NN	NN	_	11	nmod	_	_
14	into	into	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	EKLF-/-	eklf-/-	JJ	JJ	_	18	amod	_	_
17	ES	es	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	LCR/gamma-globin	lcr/gamma-globin	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	13	nmod	_	_
24	,	,	,	,	_	11	punct	_	_
25	as	as	IN	IN	_	26	mark	_	_
26	evidenced	evidence	VBN	VBN	_	11	advcl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	presence	presence	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	ES	es	NN	NN	_	33	compound	_	_
32	cell-derived	cell-derived	JJ	JJ	_	33	amod	_	_
33	reticulocytes	reticulocyte	NNS	NNS	_	29	nmod	_	_
34	as	as	RB	RB	_	33	cc	_	_
35	well	well	RB	RB	_	34	mwe	_	_
36	as	as	IN	IN	_	34	mwe	_	_
37	mature	mature	JJ	JJ	_	38	amod	_	_
38	erythrocytes	erythrocyte	NNS	NNS	_	33	conj	_	_
39	in	in	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	blood	blood	NN	NN	_	29	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	chimeric	chimeric	JJ	JJ	_	45	amod	_	_
45	animals	animal	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	11	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B/Rel	b/rel	NN	NN	_	8	compound	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
15	by	by	IN	IN	_	20	case	_	_
16	anti-HLA	anti-hla	JJ	JJ	_	20	amod	_	_
17	class	class	NN	NN	_	20	compound	_	_
18	I	i	CD	CD	_	20	nummod	_	_
19	monoclonal	monoclonal	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Monoclonal	monoclonal	JJ	JJ	_	2	amod	_	_
2	antibodies	antibody	NNS	NNS	_	13	nsubj	_	_
3	against	against	IN	IN	_	5	case	_	_
4	either	either	CC	CC	_	5	cc:preconj	_	_
5	monomorphic	monomorphic	JJ	JJ	_	2	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	polymorphic	polymorphic	JJ	JJ	_	5	conj	_	_
8	determinants	determinant	NNS	NNS	_	5	dep	_	_
9	of	of	IN	IN	_	12	case	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	I	i	CD	CD	_	12	nummod	_	_
12	antigen	antigen	NN	NN	_	5	nmod	_	_
13	induced	induce	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	PBMC	pbmc	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	highly	highly	RB	RB	_	20	advmod	_	_
18	purified	purify	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	15	conj	_	_
21	the	the	DT	DT	_	23	det	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	13	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
26	B/Rel	b/rel	NN	NN	_	27	compound	_	_
27	complexes	complex	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	included	include	VBD	VBD	_	0	root	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	p50/p50	p50/p50	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p50/p65	p50/p65	NN	NN	_	7	compound	_	_
7	dimers	dimer	NNS	NNS	_	4	conj	_	_
8	,	,	,	,	_	4	punct	_	_
9	recognized	recognize	VBN	VBN	_	4	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	antibodies	antibody	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	EMSA	emsa	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	induced	induce	VBN	VBN	_	3	amod	_	_
3	complexes	complex	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	detectable	detectable	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	extracts	extract	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	incubated	incubate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	15	case	_	_
12	anti-class	anti-class	JJ	JJ	_	15	amod	_	_
13	I	i	CD	CD	_	15	nummod	_	_
14	monoclonal	monoclonal	JJ	JJ	_	15	amod	_	_
15	antibody	antibody	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	mAb	mab	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	for	for	IN	IN	_	21	case	_	_
20	1.5	1.5	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	10	nmod	_	_
22	;	;	:	:	_	5	punct	_	_
23	the	the	DT	DT	_	24	det	_	_
24	induction	induction	NN	NN	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	maximal	maximal	JJ	JJ	_	5	parataxis	_	_
27	at	at	IN	IN	_	29	case	_	_
28	5	5	CD	CD	_	29	nummod	_	_
29	h	h	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	26	punct	_	_
31	persistent	persistent	JJ	JJ	_	26	conj	_	_
32	at	at	IN	IN	_	34	case	_	_
33	16	16	CD	CD	_	34	nummod	_	_
34	h	h	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	26	cc	_	_
36	no	no	DT	DT	_	37	neg	_	_
37	longer	longer	JJR	JJR	_	38	advmod	_	_
38	observed	observe	VBN	VBN	_	26	conj	_	_
39	at	at	IN	IN	_	41	case	_	_
40	40	40	CD	CD	_	41	nummod	_	_
41	h	h	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mAb	mab	NN	NN	_	3	nsubj	_	_
3	failed	fail	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	induce	induce	VB	VB	_	3	xcomp	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B/Rel	b/rel	NN	NN	_	9	compound	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	incubated	incubate	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	3,4-dichloroisocoumarin	3,4-dichloroisocoumarin	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	an	a	DT	DT	_	20	det	_	_
20	inhibitor	inhibitor	NN	NN	_	17	appos	_	_
21	of	of	IN	IN	_	25	case	_	_
22	I	i	NN	NN	_	24	compound	_	_
23	kappa	kappa	NN	NN	_	24	compound	_	_
24	B-alpha	b-alpha	NN	NN	_	25	compound	_	_
25	degradation	degradation	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	class	class	NN	NN	_	9	compound	_	_
8	I	i	CD	CD	_	9	nummod	_	_
9	triggering	triggering	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	induce	induce	VB	VB	_	5	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B/Rel	b/rel	NN	NN	_	18	compound	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	13	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
21	blood	blood	NN	NN	_	23	compound	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
24	,	,	,	,	_	11	punct	_	_
25	thereby	thereby	RB	RB	_	26	advmod	_	_
26	modulating	modulate	VBG	VBG	_	11	advcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	genes	gene	NNS	NNS	_	28	nmod	_	_
31	regulated	regulate	VBN	VBN	_	30	acl	_	_
32	by	by	IN	IN	_	35	case	_	_
33	these	these	DT	DT	_	35	det	_	_
34	transcription	transcription	NN	NN	_	35	compound	_	_
35	factors	factor	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	EBF	ebf	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	E47	e47	NN	NN	_	1	conj	_	_
4	collaborate	collaborate	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	induce	induce	VB	VB	_	4	xcomp	_	_
7	expression	expression	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
11	immunoglobulin	immunoglobulin	NN	NN	_	15	compound	_	_
12	surrogate	surrogate	JJ	JJ	_	15	amod	_	_
13	light	light	JJ	JJ	_	15	amod	_	_
14	chain	chain	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Early	early	JJ	JJ	_	4	amod	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	10	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EBF	ebf	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	E47	e47	NN	NN	_	4	conj	_	_
10	participate	participate	VBP	VBP	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	control	control	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	early	early	JJ	JJ	_	19	amod	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	aim	aim	NN	NN	_	15	nmod	_	_
4	of	of	IN	IN	_	5	mark	_	_
5	identifying	identify	VBG	VBG	_	3	acl	_	_
6	genetic	genetic	JJ	JJ	_	7	amod	_	_
7	targets	target	NNS	NNS	_	5	dobj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	these	these	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	we	we	PRP	PRP	_	15	nsubj	_	_
14	stably	stably	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBD	VBD	_	0	root	_	_
16	cDNAs	cdna	NNS	NNS	_	15	dobj	_	_
17	encoding	encode	VBG	VBG	_	16	acl	_	_
18	EBF	ebf	NN	NN	_	17	dobj	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	a	a	DT	DT	_	22	det	_	_
21	covalent	covalent	JJ	JJ	_	22	amod	_	_
22	homodimer	homodimer	NN	NN	_	18	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	E47	e47	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	15	punct	_	_
26	individually	individually	RB	RB	_	27	advmod	_	_
27	or	or	CC	CC	_	15	advmod	_	_
28	together	together	RB	RB	_	27	advmod	_	_
29	,	,	,	,	_	15	punct	_	_
30	into	into	IN	IN	_	34	case	_	_
31	immature	immature	JJ	JJ	_	34	amod	_	_
32	hematopoietic	hematopoietic	JJ	JJ	_	34	amod	_	_
33	Ba/F3	ba/f3	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	15	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	which	which	WDT	WDT	_	37	nsubj	_	_
37	lack	lack	VBP	VBP	_	34	acl:relcl	_	_
38	both	both	DT	DT	_	39	det	_	_
39	factors	factor	NNS	NNS	_	37	dobj	_	_
40	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	combination	combination	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	EBF	ebf	NN	NN	_	7	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	E47	e47	NN	NN	_	4	conj	_	_
7	induce	induce	VBP	VBP	_	0	root	_	_
8	efficient	efficient	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	endogenous	endogenous	JJ	JJ	_	17	amod	_	_
13	immunoglobulin	immunoglobulin	NN	NN	_	17	compound	_	_
14	surrogate	surrogate	JJ	JJ	_	17	amod	_	_
15	light	light	JJ	JJ	_	17	amod	_	_
16	chain	chain	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	9	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	lambda5	lambda5	NN	NN	_	17	appos	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	VpreB	vpreb	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	7	punct	_	_
23	whereas	whereas	IN	IN	_	28	mark	_	_
24	other	other	JJ	JJ	_	27	amod	_	_
25	pre-B	pre-b	JJ	JJ	_	27	amod	_	_
26	cell-specific	cell-specific	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	28	nsubj	_	_
28	remain	remain	VBP	VBP	_	7	advcl	_	_
29	silent	silent	JJ	JJ	_	28	xcomp	_	_
30	.	.	.	.	_	7	punct	_	_

1	Multiple	multiple	JJ	JJ	_	2	advmod	_	_
2	functionally	functionally	RB	RB	_	3	advmod	_	_
3	important	important	JJ	JJ	_	4	amod	_	_
4	EBF	ebf	NN	NN	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	E47	e47	NN	NN	_	4	conj	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	4	dep	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	lambda5	lambda5	NN	NN	_	15	compound	_	_
14	promoter/enhancer	promoter/enhancer	NN	NN	_	15	compound	_	_
15	region	region	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	10	punct	_	_
17	indicating	indicate	VBG	VBG	_	10	advcl	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	lambda5	lambda5	NN	NN	_	24	nsubj	_	_
20	is	be	VBZ	VBZ	_	24	cop	_	_
21	a	a	DT	DT	_	24	det	_	_
22	direct	direct	JJ	JJ	_	24	amod	_	_
23	genetic	genetic	JJ	JJ	_	22	dep	_	_
24	target	target	NN	NN	_	17	ccomp	_	_
25	for	for	IN	IN	_	28	case	_	_
26	these	these	DT	DT	_	28	det	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	EBF	ebf	NN	NN	_	11	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	E47	e47	NN	NN	_	8	conj	_	_
11	synergize	synergize	VBP	VBP	_	6	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	activate	activate	VB	VB	_	11	xcomp	_	_
14	expression	expression	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	subset	subset	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	genes	gene	NNS	NNS	_	17	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	define	define	VBP	VBP	_	17	acl:relcl	_	_
22	an	a	DT	DT	_	24	det	_	_
23	early	early	JJ	JJ	_	24	amod	_	_
24	stage	stage	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lineage	lineage	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	correlate	correlate	VBP	VBP	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	syncytium-forming	syncytium-forming	JJ	JJ	_	8	amod	_	_
8	capacity	capacity	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	8e51	8e51	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	expressing	express	VBG	VBG	_	11	acl	_	_
14	a	a	DT	DT	_	17	det	_	_
15	defective	defective	JJ	JJ	_	17	amod	_	_
16	HIV	hiv	NN	NN	_	17	compound	_	_
17	virus	virus	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	double	double	JJ	JJ	_	4	amod	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	19	nsubjpass	_	_
5	identified	identify	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	LTR	ltr	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	13	compound	_	_
13	virus-1	virus-1	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HIV-1	hiv-1	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	has	have	VBZ	VBZ	_	19	aux	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	necessary	necessary	JJ	JJ	_	19	xcomp	_	_
23	for	for	IN	IN	_	26	case	_	_
24	efficient	efficient	JJ	JJ	_	26	amod	_	_
25	viral	viral	JJ	JJ	_	26	amod	_	_
26	transcription	transcription	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	present	present	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	characterisation	characterisation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	subunits	subunit	NNS	NNS	_	7	nmod	_	_
11	engaged	engage	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	13	case	_	_
13	complexes	complex	NNS	NNS	_	11	nmod	_	_
14	binding	bind	VBG	VBG	_	13	acl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	8e51	8e51	NN	NN	_	23	compound	_	_
23	T-cells	t-cell	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	harbour	harbour	VBP	VBP	_	23	acl:relcl	_	_
27	a	a	DT	DT	_	29	det	_	_
28	defective	defective	JJ	JJ	_	29	amod	_	_
29	HIV-1	hiv-1	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	5	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	least	least	JJS	JJS	_	3	nmod:npmod	_	_
3	four	four	CD	CD	_	7	nummod	_	_
4	different	different	JJ	JJ	_	7	amod	_	_
5	specific	specific	JJ	JJ	_	4	dep	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	complexes	complex	NNS	NNS	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	present	present	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	nucleus	nucleus	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	use	use	NN	NN	_	9	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	specific	specific	JJ	JJ	_	6	amod	_	_
6	antibodies	antibody	NNS	NNS	_	3	nmod	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	determined	determine	VBN	VBN	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	composition	composition	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	each	each	DT	DT	_	14	det	_	_
14	complex	complex	NN	NN	_	11	nmod	_	_
15	using	use	VBG	VBG	_	9	xcomp	_	_
16	electrophoretic	electrophoretic	JJ	JJ	_	19	amod	_	_
17	mobility	mobility	NN	NN	_	19	compound	_	_
18	shift	shift	NN	NN	_	19	compound	_	_
19	assays	assay	NNS	NNS	_	15	dobj	_	_
20	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	several	several	JJ	JJ	_	10	amod	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	members	member	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	with	with	IN	IN	_	17	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transactivating	transactivate	VBG	VBG	_	15	amod	_	_
15	RelA	rela	NN	NN	_	17	nsubjpass	_	_
16	being	be	VBG	VBG	_	17	auxpass	_	_
17	engaged	engage	VBN	VBN	_	3	advcl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	multiple	multiple	JJ	JJ	_	20	amod	_	_
20	complexes	complex	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	complexes	complex	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	viral	viral	JJ	JJ	_	8	amod	_	_
8	functions	function	NNS	NNS	_	2	nmod	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	established	establish	VBN	VBN	_	0	root	_	_
12	comparing	compare	VBG	VBG	_	11	xcomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	level	level	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
17	DNA-binding	dna-binding	JJ	JJ	_	18	amod	_	_
18	complexes	complex	NNS	NNS	_	14	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	syncytia-forming	syncytia-forming	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	12	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	8e51	8e51	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	8e51	8e51	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	14	nsubjpass	_	_
6	that	that	WDT	WDT	_	9	nsubj	_	_
7	had	have	VBD	VBD	_	9	aux	_	_
8	almost	almost	RB	RB	_	9	advmod	_	_
9	lost	lose	VBN	VBN	_	5	acl:relcl	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	syncytia-forming	syncytia-forming	JJ	JJ	_	12	amod	_	_
12	capacity	capacity	NN	NN	_	9	dobj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	contain	contain	VB	VB	_	14	xcomp	_	_
17	at	at	IN	IN	_	18	case	_	_
18	least	least	JJS	JJS	_	20	nmod:npmod	_	_
19	10	10	CD	CD	_	20	compound	_	_
20	times	time	NNS	NNS	_	22	dep	_	_
21	less	less	RBR	RBR	_	20	advmod	_	_
22	active	active	JJ	JJ	_	25	dep	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	25	compound	_	_
24	DNA-binding	dna-binding	JJ	JJ	_	25	amod	_	_
25	complex	complex	NN	NN	_	16	dobj	_	_
26	than	than	IN	IN	_	30	mark	_	_
27	the	the	DT	DT	_	30	det	_	_
28	actively	actively	RB	RB	_	30	advmod	_	_
29	fusing	fuse	VBG	VBG	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	25	dep	_	_
31	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	correlation	correlation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	specific	specific	JJ	JJ	_	0	root	_	_
5	as	as	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	level	level	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	at	at	IN	IN	_	10	case	_	_
10	least	least	JJS	JJS	_	11	nmod:npmod	_	_
11	three	three	CD	CD	_	14	nummod	_	_
12	other	other	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	7	nmod	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	change	change	VB	VB	_	4	advcl	_	_
18	.	.	.	.	_	4	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	interaction	interaction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	leukocyte-specific	leukocyte-specific	JJ	JJ	_	10	amod	_	_
9	pp52	pp52	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	2	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	B	b	NN	NN	_	2	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	T	t	NN	NN	_	12	conj	_	_
15	cells	cell	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	11	det	_	_
2	leukocyte-specific	leukocyte-specific	JJ	JJ	_	11	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	cytoskeleton-binding	cytoskeleton-binding	JJ	JJ	_	2	dep	_	_
5	pp52	pp52	NN	NN	_	11	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	LSP-1	lsp-1	NN	NN	_	5	dep	_	_
8	,	,	,	,	_	7	punct	_	_
9	WP-34	wp-34	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	7	punct	_	_
11	protein	protein	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	widely	widely	RB	RB	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	multiple	multiple	JJ	JJ	_	18	amod	_	_
17	leukocyte	leukocyte	NN	NN	_	18	compound	_	_
18	lineages	lineage	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	T	t	NN	NN	_	21	conj	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	21	dep	_	_
25	,	,	,	,	_	21	punct	_	_
26	granulocytes	granulocyte	NNS	NNS	_	21	conj	_	_
27	,	,	,	,	_	21	punct	_	_
28	and	and	CC	CC	_	21	cc	_	_
29	macrophages	macrophage	NNS	NNS	_	21	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	detected	detect	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	tissue-specific	tissue-specific	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	3	dobj	_	_
7	preceding	precede	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	exon	exon	NN	NN	_	7	dobj	_	_
10	encoding	encode	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	N	n	NN	NN	_	13	compound	_	_
13	terminus	terminus	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	pp52	pp52	NN	NN	_	18	compound	_	_
17	leukocyte	leukocyte	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	characterization	characterization	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	identification	identification	NN	NN	_	6	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	B	b	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	T	t	NN	NN	_	16	conj	_	_
19	cells	cell	NNS	NNS	_	16	dep	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	regulate	regulate	VBP	VBP	_	16	acl:relcl	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	activity	activity	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	pp52	pp52	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	6	det	_	_
6	initiator	initiator	NN	NN	_	4	dobj	_	_
7	specifying	specify	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	unique	unique	JJ	JJ	_	11	amod	_	_
10	5'	5'	JJ	JJ	_	11	amod	_	_
11	terminus	terminus	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	pp52	pp52	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	tandem	tandem	JJ	JJ	_	17	amod	_	_
17	pairs	pair	NNS	NNS	_	6	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Ets	ets	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	SP1	sp1	NN	NN	_	19	conj	_	_
22	motifs	motif	NNS	NNS	_	19	dep	_	_
23	,	,	,	,	_	6	punct	_	_
24	and	and	CC	CC	_	6	cc	_	_
25	a	a	DT	DT	_	28	det	_	_
26	lone	lone	JJ	JJ	_	28	amod	_	_
27	C/EBP	c/ebp	NN	NN	_	28	compound	_	_
28	motif	motif	NN	NN	_	6	conj	_	_
29	.	.	.	.	_	4	punct	_	_

1	All	all	PDT	PDT	_	3	det:predet	_	_
2	these	these	DT	DT	_	3	det	_	_
3	motifs	motif	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	essential	essential	JJ	JJ	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	collectively	collectively	RB	RB	_	8	advmod	_	_
8	control	control	VBP	VBP	_	5	conj	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	5	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Ab	ab	NN	NN	_	7	compound	_	_
6	supershift	supershift	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	3	conj	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	combinations	combination	NNS	NNS	_	14	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	factors	factor	NNS	NNS	_	11	nmod	_	_
14	interact	interact	VBP	VBP	_	8	ccomp	_	_
15	with	with	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	motifs	motif	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	vs	vs	CC	CC	_	20	cc	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Ets	ets	NN	NN	_	3	compound	_	_
3	motifs	motif	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	preferentially	preferentially	RB	RB	_	6	advmod	_	_
6	bound	bind	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	PU-1	pu-1	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	extracts	extract	NNS	NNS	_	6	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	all	all	DT	DT	_	15	det	_	_
15	stages	stage	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	development	development	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	whereas	whereas	IN	IN	_	25	mark	_	_
20	a	a	DT	DT	_	24	det	_	_
21	different	different	JJ	JJ	_	24	amod	_	_
22	Ets	ets	NN	NN	_	24	compound	_	_
23	family	family	NN	NN	_	24	compound	_	_
24	member	member	NN	NN	_	25	nsubj	_	_
25	reacts	react	VBZ	VBZ	_	6	advcl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	motifs	motif	NNS	NNS	_	25	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	extracts	extract	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	C/EBP	c/ebp	NN	NN	_	3	compound	_	_
3	motif	motif	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	bound	bind	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	Ig/EBP-1	ig/ebp-1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	pre-B	pre-b	JJ	JJ	_	10	amod	_	_
10	cell	cell	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cell	cell	NN	NN	_	10	conj	_	_
14	extracts	extract	NNS	NNS	_	10	dep	_	_
15	,	,	,	,	_	5	punct	_	_
16	but	but	CC	CC	_	5	cc	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	replaced	replace	VBN	VBN	_	5	conj	_	_
19	by	by	IN	IN	_	21	case	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	factor-IL-6beta	factor-il-6beta	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	a	a	DT	DT	_	26	det	_	_
24	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
25	factor-IL-6beta-Ig/EBP-1	factor-il-6beta-ig/ebp-1	NN	NN	_	26	compound	_	_
26	heterodimer	heterodimer	NN	NN	_	21	conj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	plasmacytoma	plasmacytoma	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	extracts	extract	NNS	NNS	_	18	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
3	reported	report	VBN	VBN	_	4	amod	_	_
4	role	role	NN	NN	_	13	nmod	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	regulator	regulator	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	Ig/EBP-1	ig/ebp-1	NN	NN	_	13	nsubj	_	_
13	appears	appear	VBZ	VBZ	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	exert	exert	VB	VB	_	13	xcomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	stimulatory	stimulatory	JJ	JJ	_	18	amod	_	_
18	effect	effect	NN	NN	_	15	dobj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	features	feature	NNS	NNS	_	3	dobj	_	_
6	controlling	control	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	pp52	pp52	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	B	b	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	T	t	NN	NN	_	11	conj	_	_
14	cells	cell	NNS	NNS	_	11	dep	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	provide	provide	VBP	VBP	_	3	conj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	foundation	foundation	NN	NN	_	16	dobj	_	_
19	for	for	IN	IN	_	20	mark	_	_
20	determining	determine	VBG	VBG	_	18	acl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	regulation	regulation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	promoter	promoter	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	other	other	JJ	JJ	_	29	amod	_	_
28	leukocyte	leukocyte	NN	NN	_	29	compound	_	_
29	lineages	lineage	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Synthetic	synthetic	JJ	JJ	_	2	amod	_	_
2	glucocorticoids	glucocorticoid	NNS	NNS	_	9	nsubj	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	dissociate	dissociate	VBP	VBP	_	2	acl:relcl	_	_
5	transactivation	transactivation	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	transrepression	transrepression	NN	NN	_	5	conj	_	_
9	exhibit	exhibit	VBP	VBP	_	0	root	_	_
10	antiinflammatory	antiinflammatory	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	9	advmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Some	some	DT	DT	_	12	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	potent	potent	JJ	JJ	_	9	amod	_	_
6	antiinflammatory	antiinflammatory	JJ	JJ	_	5	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	immunosuppressive	immunosuppressive	JJ	JJ	_	6	conj	_	_
9	agents	agent	NNS	NNS	_	1	nmod	_	_
10	are	be	VBP	VBP	_	12	cop	_	_
11	synthetic	synthetic	JJ	JJ	_	12	amod	_	_
12	glucocorticoids	glucocorticoid	NNS	NNS	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	major	major	JJ	JJ	_	5	amod	_	_
4	side	side	NN	NN	_	5	compound	_	_
5	effects	effect	NNS	NNS	_	7	nsubj	_	_
6	severely	severely	RB	RB	_	7	advmod	_	_
7	limit	limit	VBP	VBP	_	0	root	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	therapeutic	therapeutic	JJ	JJ	_	10	amod	_	_
10	use	use	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	development	development	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	improved	improved	JJ	JJ	_	6	amod	_	_
5	glucocorticoid-based	glucocorticoid-based	JJ	JJ	_	4	dep	_	_
6	drugs	drug	NNS	NNS	_	2	nmod	_	_
7	will	will	MD	MD	_	8	aux	_	_
8	require	require	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	separation	separation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	beneficial	beneficial	JJ	JJ	_	10	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	deleterious	deleterious	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	possibility	possibility	NN	NN	_	6	nsubj	_	_
3	toward	toward	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	goal	goal	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	try	try	VB	VB	_	6	xcomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	dissociate	dissociate	VB	VB	_	8	xcomp	_	_
11	two	two	CD	CD	_	13	nummod	_	_
12	main	main	JJ	JJ	_	13	amod	_	_
13	activities	activity	NNS	NNS	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	i.e.	i.e.	FW	FW	_	13	acl	_	_
18	transactivation	transactivation	NN	NN	_	13	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	transrepression	transrepression	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	Screening	screening	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	library	library	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	compounds	compound	NNS	NNS	_	4	nmod	_	_
7	using	use	VBG	VBG	_	1	dep	_	_
8	transactivation	transactivation	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP-1	ap-1	NN	NN	_	11	compound	_	_
11	transrepression	transrepression	NN	NN	_	8	conj	_	_
12	models	model	NNS	NNS	_	8	dep	_	_
13	in	in	IN	IN	_	16	case	_	_
14	transiently	transiently	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBN	VBN	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	7	nmod	_	_
17	identified	identify	VBD	VBD	_	0	root	_	_
18	dissociated	dissociate	VBN	VBN	_	19	amod	_	_
19	glucocorticoids	glucocorticoid	NNS	NNS	_	17	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	exert	exert	VBP	VBP	_	19	acl:relcl	_	_
23	strong	strong	JJ	JJ	_	25	amod	_	_
24	AP-1	ap-1	NN	NN	_	25	compound	_	_
25	inhibition	inhibition	NN	NN	_	22	dobj	_	_
26	but	but	CC	CC	_	25	cc	_	_
27	little	little	JJ	JJ	_	25	conj	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	no	no	DT	DT	_	27	conj	_	_
30	transactivation	transactivation	NN	NN	_	27	dep	_	_
31	.	.	.	.	_	17	punct	_	_

1	Importantly	importantly	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	despite	despite	IN	IN	_	7	case	_	_
4	high	high	JJ	JJ	_	7	amod	_	_
5	ligand	ligand	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	affinity	affinity	NN	NN	_	16	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	the	the	DT	DT	_	12	det	_	_
10	prototypic	prototypic	JJ	JJ	_	11	dep	_	_
11	dissociated	dissociate	VBN	VBN	_	12	amod	_	_
12	compound	compound	NN	NN	_	16	nsubj	_	_
13	,	,	,	,	_	12	punct	_	_
14	RU24858	ru24858	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	12	punct	_	_
16	acted	act	VBD	VBD	_	0	root	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	weak	weak	JJ	JJ	_	20	amod	_	_
20	agonist	agonist	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	did	do	VBD	VBD	_	25	aux	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	efficiently	efficiently	RB	RB	_	25	advmod	_	_
25	antagonize	antagonize	VB	VB	_	16	conj	_	_
26	dexamethasone-induced	dexamethasone-induced	JJ	JJ	_	27	amod	_	_
27	transcription	transcription	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	transfected	transfect	VBN	VBN	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	hepatic	hepatic	JJ	JJ	_	8	amod	_	_
7	HTC	htc	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	transactivation	transactivation	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	endogenous	endogenous	JJ	JJ	_	18	amod	_	_
15	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
16	amino	amino	NN	NN	_	18	compound	_	_
17	transferase	transferase	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	11	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TAT	tat	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	18	punct	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	encodes	encode	VBZ	VBZ	_	18	acl:relcl	_	_
25	one	one	CD	CD	_	24	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	enzymes	enzyme	NNS	NNS	_	25	nmod	_	_
29	involved	involve	VBN	VBN	_	28	acl	_	_
30	in	in	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	glucocorticoid-dependent	glucocorticoid-dependent	JJ	JJ	_	33	amod	_	_
33	stimulation	stimulation	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	neoglucogenesis	neoglucogenesis	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	dissociated	dissociate	VBN	VBN	_	5	amod	_	_
5	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nsubj	_	_
6	retained	retain	VBD	VBD	_	2	ccomp	_	_
7	the	the	DT	DT	_	11	det	_	_
8	antiinflammatory	antiinflammatory	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	immunosuppressive	immunosuppressive	JJ	JJ	_	8	conj	_	_
11	potential	potential	NN	NN	_	6	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	classic	classic	JJ	JJ	_	14	amod	_	_
14	glucocorticoids	glucocorticoid	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	several	several	JJ	JJ	_	17	amod	_	_
17	in	in	FW	FW	_	24	nsubjpass	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	in	in	FW	FW	_	17	conj	_	_
21	vivo	vivo	FW	FW	_	20	dep	_	_
22	models	model	NNS	NNS	_	17	dep	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	used	use	VBN	VBN	_	2	parataxis	_	_
25	.	.	.	.	_	2	punct	_	_

1	Indeed	indeed	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	secretion	secretion	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	proinflammatory	proinflammatory	JJ	JJ	_	8	amod	_	_
7	lymphokine	lymphokine	NN	NN	_	8	compound	_	_
8	interleukin-1beta	interleukin-1beta	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	severely	severely	RB	RB	_	11	advmod	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	dissociated	dissociate	VBN	VBN	_	14	amod	_	_
14	glucocorticoids	glucocorticoid	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	human	human	JJ	JJ	_	20	amod	_	_
17	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
18	THP	thp	NN	NN	_	20	compound	_	_
19	1	1	CD	CD	_	20	nummod	_	_
20	cells	cell	NNS	NNS	_	11	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	in	in	IN	IN	_	7	case	_	_
4	two	two	CD	CD	_	7	nummod	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	vivo	vivo	FW	FW	_	5	dep	_	_
7	models	model	NNS	NNS	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	these	these	DT	DT	_	10	det	_	_
10	compounds	compound	NNS	NNS	_	11	nsubj	_	_
11	exerted	exert	VBD	VBD	_	0	root	_	_
12	an	a	DT	DT	_	16	det	_	_
13	antiinflammatory	antiinflammatory	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	immunosuppressive	immunosuppressive	JJ	JJ	_	13	conj	_	_
16	activity	activity	NN	NN	_	11	dobj	_	_
17	as	as	IN	IN	_	18	dep	_	_
18	potent	potent	JJ	JJ	_	16	amod	_	_
19	as	as	IN	IN	_	20	case	_	_
20	that	that	DT	DT	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	classic	classic	JJ	JJ	_	24	amod	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	20	nmod	_	_
25	prednisolone	prednisolone	NN	NN	_	24	dep	_	_
26	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	lead	lead	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	an	a	DT	DT	_	7	det	_	_
7	improvement	improvement	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	antiinflammatory	antiinflammatory	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	immunosuppressive	immunosuppressive	JJ	JJ	_	9	conj	_	_
12	therapies	therapy	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	provide	provide	VB	VB	_	4	conj	_	_
15	a	a	DT	DT	_	17	det	_	_
16	novel	novel	JJ	JJ	_	17	amod	_	_
17	concept	concept	NN	NN	_	14	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	drug	drug	NN	NN	_	20	compound	_	_
20	discovery	discovery	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	3	compound	_	_
2	domain	domain	NN	NN	_	3	compound	_	_
3	requirements	requirement	NNS	NNS	_	0	root	_	_
4	for	for	IN	IN	_	5	case	_	_
5	disruption	disruption	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	latency	latency	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	ZEBRA	zebra	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Latent	latent	JJ	JJ	_	2	amod	_	_
2	infection	infection	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
8	virus	virus	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	EBV	ebv	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	disrupted	disrupt	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	expression	expression	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	EBV	ebv	NN	NN	_	21	compound	_	_
20	ZEBRA	zebra	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	ZEBRA	zebra	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activator	activator	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	initiates	initiate	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	EBV	ebv	NN	NN	_	11	compound	_	_
10	lytic	lytic	JJ	JJ	_	11	amod	_	_
11	cascade	cascade	NN	NN	_	7	dobj	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	activating	activate	VBG	VBG	_	7	advcl	_	_
14	viral	viral	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	7	punct	_	_

1	ZEBRA	zebra	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	indispensable	indispensable	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	viral	viral	JJ	JJ	_	7	amod	_	_
7	replication	replication	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	binds	bind	VBZ	VBZ	_	4	conj	_	_
10	directly	directly	RB	RB	_	9	advmod	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	EBV	ebv	NN	NN	_	15	compound	_	_
14	lytic	lytic	JJ	JJ	_	15	amod	_	_
15	origin	origin	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	replication	replication	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	5	nsubj	_	_
3	described	describe	VBN	VBN	_	2	acl	_	_
4	herein	herein	RB	RB	_	3	advmod	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	7	mark	_	_
7	the	the	DT	DT	_	5	dep	_	_
8	activation	activation	NN	NN	_	7	dep	_	_
9	domain	domain	NN	NN	_	7	dep	_	_
10	.	.	.	.	_	5	punct	_	_

1	ZEBRA	zebra	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	replaced	replace	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	dep	_	_
8	heterologous	heterologous	JJ	JJ	_	9	amod	_	_
9	acidic	acidic	JJ	JJ	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	proline-rich	proline-rich	JJ	JJ	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	or	or	CC	CC	_	9	cc	_	_
14	glutamine-rich	glutamine-rich	JJ	JJ	_	9	conj	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	9	dep	_	_
17	.	.	.	.	_	5	punct	_	_

1	ZEBRA	zebra	NN	NN	_	5	compound	_	_
2	activation	activation	NN	NN	_	5	compound	_	_
3	domain	domain	NN	NN	_	5	compound	_	_
4	swap	swap	NN	NN	_	5	compound	_	_
5	constructs	construct	NNS	NNS	_	6	nsubj	_	_
6	retain	retain	VBP	VBP	_	0	root	_	_
7	ZEBRA	zebra	NN	NN	_	10	nmod:poss	_	_
8	's	's	POS	POS	_	7	case	_	_
9	native	native	JJ	JJ	_	10	amod	_	_
10	abilities	ability	NNS	NNS	_	6	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	activate	activate	VB	VB	_	10	dep	_	_
13	specific	specific	JJ	JJ	_	15	amod	_	_
14	EBV	ebv	NN	NN	_	15	compound	_	_
15	promoters	promoter	NNS	NNS	_	12	dobj	_	_
16	,	,	,	,	_	12	punct	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	disrupt	disrupt	VB	VB	_	12	conj	_	_
19	EBV	ebv	NN	NN	_	20	compound	_	_
20	latency	latency	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	12	punct	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	stimulate	stimulate	VB	VB	_	12	conj	_	_
25	replication	replication	NN	NN	_	24	dobj	_	_
26	at	at	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	EBV	ebv	NN	NN	_	30	compound	_	_
29	lytic	lytic	JJ	JJ	_	30	amod	_	_
30	origin	origin	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Additional	additional	JJ	JJ	_	2	amod	_	_
2	work	work	NN	NN	_	16	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	employing	employ	VBG	VBG	_	2	acl	_	_
5	sequential	sequential	JJ	JJ	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	internal	internal	JJ	JJ	_	5	conj	_	_
8	deletions	deletion	NNS	NNS	_	5	dep	_	_
9	of	of	IN	IN	_	10	case	_	_
10	ZEBRA	zebra	NN	NN	_	5	nmod	_	_
11	's	's	POS	POS	_	10	case	_	_
12	N-terminal	n-terminal	JJ	JJ	_	14	amod	_	_
13	activation	activation	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	10	dep	_	_
15	,	,	,	,	_	2	punct	_	_
16	indicates	indicate	VBZ	VBZ	_	0	root	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	separate	separate	JJ	JJ	_	20	amod	_	_
20	activities	activity	NNS	NNS	_	23	nsubj	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	attributable	attributable	JJ	JJ	_	16	ccomp	_	_
24	to	to	TO	TO	_	26	case	_	_
25	specific	specific	JJ	JJ	_	26	amod	_	_
26	subdomains	subdomain	NNS	NNS	_	23	nmod	_	_
27	but	but	CC	CC	_	23	cc	_	_
28	are	be	VBP	VBP	_	29	auxpass	_	_
29	spread	spread	VBN	VBN	_	23	conj	_	_
30	throughout	throughout	IN	IN	_	33	case	_	_
31	its	its	PRP$	PRP$	_	33	nmod:poss	_	_
32	N	n	NN	NN	_	33	compound	_	_
33	terminus	terminus	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	therefore	therefore	RB	RB	_	39	advmod	_	_
36	can	can	MD	MD	_	39	aux	_	_
37	not	not	RB	RB	_	39	neg	_	_
38	be	be	VB	VB	_	39	auxpass	_	_
39	inactivated	inactivate	VBN	VBN	_	29	conj	_	_
40	by	by	IN	IN	_	41	mark	_	_
41	deleting	delete	VBG	VBG	_	39	advcl	_	_
42	localized	localized	JJ	JJ	_	43	amod	_	_
43	regions	region	NNS	NNS	_	41	dobj	_	_
44	.	.	.	.	_	16	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	GATA-3	gata-3	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	differentially	differentially	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	murine	murine	JJ	JJ	_	9	amod	_	_
9	Th1	th1	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Th2	th2	NN	NN	_	9	conj	_	_
12	cells	cell	NNS	NNS	_	9	dep	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	controls	control	VBZ	VBZ	_	6	conj	_	_
15	Th2-specific	th2-specific	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	interleukin-5	interleukin-5	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Interleukin-5	interleukin-5	NN	NN	_	25	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-5	il-5	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	which	which	WDT	WDT	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	produced	produce	VBN	VBN	_	1	acl:relcl	_	_
9	by	by	IN	IN	_	17	case	_	_
10	CD4(+)	cd4(+)	JJ	JJ	_	17	amod	_	_
11	T	t	NN	NN	_	17	compound	_	_
12	helper	helper	NN	NN	_	17	compound	_	_
13	2	2	CD	CD	_	17	nummod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	Th2	th2	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	cells	cell	NNS	NNS	_	8	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	but	but	CC	CC	_	17	cc	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	by	by	IN	IN	_	23	case	_	_
22	Th1	th1	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	conj	_	_
24	,	,	,	,	_	1	punct	_	_
25	plays	play	VBZ	VBZ	_	0	root	_	_
26	a	a	DT	DT	_	28	det	_	_
27	key	key	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	development	development	NN	NN	_	25	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	eosinophilia	eosinophilia	NN	NN	_	31	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	asthma	asthma	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	25	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	increasing	increase	VBG	VBG	_	3	amod	_	_
3	evidence	evidence	NN	NN	_	38	nmod	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	outcome	outcome	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	many	many	JJ	JJ	_	9	amod	_	_
9	diseases	disease	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	determined	determine	VBN	VBN	_	3	ccomp	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ratio	ratio	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	subsets	subset	NNS	NNS	_	14	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	CD4(+)	cd4(+)	JJ	JJ	_	23	amod	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	helper	helper	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	Th1	th1	NN	NN	_	18	appos	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	Th2	th2	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	38	punct	_	_
29	the	the	DT	DT	_	31	det	_	_
30	molecular	molecular	JJ	JJ	_	31	amod	_	_
31	basis	basis	NN	NN	_	38	nsubj	_	_
32	for	for	IN	IN	_	33	case	_	_
33	Th1-	th1-	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	Th2-specific	th2-specific	JJ	JJ	_	33	conj	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	expression	expression	NN	NN	_	33	dep	_	_
38	remains	remain	VBZ	VBZ	_	0	root	_	_
39	to	to	TO	TO	_	41	mark	_	_
40	be	be	VB	VB	_	41	auxpass	_	_
41	elucidated	elucidate	VBN	VBN	_	38	xcomp	_	_
42	.	.	.	.	_	38	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	established	establish	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	critical	critical	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	6	nmod	_	_
11	GATA-3	gata-3	NN	NN	_	10	dep	_	_
12	in	in	IN	IN	_	15	case	_	_
13	IL-5	il-5	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	6	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	EL-4	el-4	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	which	which	WDT	WDT	_	21	nsubj	_	_
21	express	express	VBP	VBP	_	15	acl:relcl	_	_
22	both	both	CC	CC	_	23	cc:preconj	_	_
23	Th1-	th1-	NN	NN	_	21	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Th2-type	th2-type	JJ	JJ	_	23	conj	_	_
26	cytokines	cytokine	NNS	NNS	_	23	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	5	nsubj	_	_
3	reported	report	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	GATA-3	gata-3	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	critical	critical	JJ	JJ	_	5	ccomp	_	_
10	for	for	IN	IN	_	11	case	_	_
11	expression	expression	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-5	il-5	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	bona	bona	FW	FW	_	20	compound	_	_
18	fide	fide	FW	FW	_	20	compound	_	_
19	Th2	th2	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	11	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Whereas	whereas	IN	IN	_	7	mark	_	_
2	mutations	mutation	NNS	NNS	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	GATA-3	gata-3	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	2	nmod	_	_
7	abolished	abolish	VBD	VBD	_	33	advcl	_	_
8	antigen-	antigen-	JJ	JJ	_	7	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	cAMP-stimulated	camp-stimulated	JJ	JJ	_	8	conj	_	_
11	IL-5	il-5	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	8	dep	_	_
14	in	in	IN	IN	_	16	case	_	_
15	Th2	th2	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	33	punct	_	_
18	ectopic	ectopic	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	33	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	GATA-3	gata-3	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	Th1	th1	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	in	in	IN	IN	_	32	case	_	_
27	a	a	DT	DT	_	32	det	_	_
28	non-lymphoid	non-lymphoid	JJ	JJ	_	32	amod	_	_
29	,	,	,	,	_	32	punct	_	_
30	non-IL-5-producing	non-il-5-producing	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	line	line	NN	NN	_	24	conj	_	_
33	activated	activate	VBD	VBD	_	0	root	_	_
34	the	the	DT	DT	_	36	det	_	_
35	IL-5	il-5	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	33	dobj	_	_
37	.	.	.	.	_	33	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	differentiation	differentiation	NN	NN	_	21	nmod	_	_
4	of	of	IN	IN	_	8	case	_	_
5	naive	naive	JJ	JJ	_	8	amod	_	_
6	CD4(+)	cd4(+)	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	isolated	isolate	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	15	case	_	_
11	T	t	NN	NN	_	15	compound	_	_
12	cell	cell	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	transgenic	transgenic	JJ	JJ	_	15	amod	_	_
15	mice	mouse	NNS	NNS	_	9	nmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	GATA-3	gata-3	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
22	in	in	IN	IN	_	25	case	_	_
23	developing	develop	VBG	VBG	_	25	amod	_	_
24	Th2	th2	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	but	but	CC	CC	_	21	cc	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	down-regulated	down-regulate	VBN	VBN	_	21	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	Th1	th1	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	,	,	,	,	_	21	punct	_	_
34	and	and	CC	CC	_	21	cc	_	_
35	antigen-	antigen-	NN	NN	_	39	compound	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	cAMP-activated	camp-activated	JJ	JJ	_	35	conj	_	_
38	Th2	th2	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	46	nsubj	_	_
40	(	(	-LRB-	-LRB-	_	44	punct	_	_
41	but	but	CC	CC	_	42	cc	_	_
42	not	not	RB	RB	_	44	cc	_	_
43	Th1	th1	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	39	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	expressed	express	VBD	VBD	_	21	conj	_	_
47	the	the	DT	DT	_	49	det	_	_
48	GATA-3	gata-3	NN	NN	_	49	compound	_	_
49	protein	protein	NN	NN	_	46	dobj	_	_
50	.	.	.	.	_	21	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	GATA-3	gata-3	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	play	play	VB	VB	_	0	root	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	balance	balance	NN	NN	_	5	nmod	_	_
12	between	between	IN	IN	_	13	case	_	_
13	Th1	th1	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Th2	th2	NN	NN	_	16	compound	_	_
16	subsets	subset	NNS	NNS	_	13	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	responses	response	NNS	NNS	_	5	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Inhibition	inhibition	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	GATA-3	gata-3	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	therapeutic	therapeutic	JJ	JJ	_	7	amod	_	_
7	potential	potential	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	treatment	treatment	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	asthma	asthma	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	hypereosinophilic	hypereosinophilic	JJ	JJ	_	16	amod	_	_
16	diseases	disease	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	immune-mediated	immune-mediated	JJ	JJ	_	5	amod	_	_
5	disease	disease	NN	NN	_	2	nmod	_	_
6	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	large	large	JJ	JJ	_	3	amod	_	_
3	amount	amount	NN	NN	_	24	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	detailed	detailed	JJ	JJ	_	6	amod	_	_
6	information	information	NN	NN	_	3	nmod	_	_
7	about	about	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	3	nmod	_	_
11	regulating	regulate	VBG	VBG	_	10	acl	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	14	conj	_	_
19	to	to	TO	TO	_	22	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	18	nmod	_	_
23	has	have	VBZ	VBZ	_	24	aux	_	_
24	emerged	emerge	VBN	VBN	_	0	root	_	_
25	recently	recently	RB	RB	_	24	advmod	_	_
26	.	.	.	.	_	24	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	small	small	JJ	JJ	_	3	amod	_	_
3	molecules	molecule	NNS	NNS	_	20	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	an	a	DT	DT	_	7	det	_	_
6	antisense	antisense	JJ	JJ	_	7	amod	_	_
7	oligonucleotide	oligonucleotide	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	gene	gene	NN	NN	_	12	compound	_	_
11	therapeutic	therapeutic	JJ	JJ	_	12	amod	_	_
12	agents	agent	NNS	NNS	_	3	conj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	inhibit	inhibit	VBP	VBP	_	12	acl:relcl	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	b	b	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	have	have	VBP	VBP	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	described	describe	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Despite	despite	IN	IN	_	2	case	_	_
2	this	this	DT	DT	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	are	be	VBP	VBP	_	0	root	_	_
6	still	still	RB	RB	_	5	advmod	_	_
7	significant	significant	JJ	JJ	_	8	amod	_	_
8	gaps	gap	NNS	NNS	_	5	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	our	we	PRP$	PRP$	_	11	nmod:poss	_	_
11	understanding	understanding	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	process	process	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	consequences	consequence	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	characterization	characterization	NN	NN	_	23	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	selectively	selectively	RB	RB	_	10	advmod	_	_
10	regulating	regulate	VBG	VBG	_	8	acl	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	by	by	IN	IN	_	17	case	_	_
14	CD4+	cd4+	JJ	JJ	_	17	amod	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	subsets	subset	NNS	NNS	_	12	nmod	_	_
18	is	be	VBZ	VBZ	_	23	cop	_	_
19	at	at	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	very	very	RB	RB	_	22	advmod	_	_
22	early	early	JJ	JJ	_	23	amod	_	_
23	stage	stage	NN	NN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	interacting	interact	VBG	VBG	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	7	nsubjpass	_	_
4	have	have	VBP	VBP	_	7	aux	_	_
5	recently	recently	RB	RB	_	7	advmod	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	contribute	contribute	VB	VB	_	7	xcomp	_	_
10	to	to	TO	TO	_	12	case	_	_
11	subset-restricted	subset-restricted	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-4	il-4	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	are	be	VBP	VBP	_	0	root	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	elements	element	NNS	NNS	_	2	nsubj	_	_
5	regulating	regulate	VBG	VBG	_	4	acl	_	_
6	IL-4	il-4	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	2	punct	_	_
10	however	however	RB	RB	_	2	advmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	relative	relative	JJ	JJ	_	15	amod	_	_
15	importance	importance	NN	NN	_	21	nsubj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	these	these	DT	DT	_	20	det	_	_
18	recently	recently	RB	RB	_	19	advmod	_	_
19	identified	identify	VBN	VBN	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	15	nmod	_	_
21	has	have	VBZ	VBZ	_	2	conj	_	_
22	yet	yet	RB	RB	_	25	advmod	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	determined	determine	VBN	VBN	_	21	xcomp	_	_
26	.	.	.	.	_	2	punct	_	_

1	alpha-Tocopheryl	alpha-tocopheryl	NN	NN	_	2	compound	_	_
2	succinate	succinate	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	adhesion	adhesion	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	suppressing	suppress	VBG	VBG	_	3	advcl	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	mobilization	mobilization	NN	NN	_	11	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	adherence	adherence	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	endothelium	endothelium	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	an	a	DT	DT	_	11	det	_	_
10	early	early	JJ	JJ	_	11	amod	_	_
11	event	event	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	atherogenesis	atherogenesis	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	11	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	antioxidants	antioxidant	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	considered	consider	VBN	VBN	_	13	advcl	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	of	of	IN	IN	_	10	case	_	_
9	antiatherosclerotic	antiatherosclerotic	JJ	JJ	_	10	amod	_	_
10	potential	potential	NN	NN	_	5	xcomp	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	investigated	investigate	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effects	effect	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	alpha-tocopherol	alpha-tocopherol	NN	NN	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TCP	tcp	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	acetate	acetate	NN	NN	_	17	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	succinate	succinate	NN	NN	_	23	conj	_	_
26	esters	ester	NNS	NNS	_	23	dep	_	_
27	on	on	IN	IN	_	29	case	_	_
28	monocyte	monocyte	NN	NN	_	29	compound	_	_
29	adhesion	adhesion	NN	NN	_	15	nmod	_	_
30	to	to	TO	TO	_	36	case	_	_
31	cytokine-stimulated	cytokine-stimulated	JJ	JJ	_	36	amod	_	_
32	human	human	JJ	JJ	_	36	amod	_	_
33	umbilical	umbilical	JJ	JJ	_	36	amod	_	_
34	vein	vein	NN	NN	_	36	compound	_	_
35	endothelial	endothelial	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	29	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	HUVEC	huvec	NNS	NNS	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	13	punct	_	_

1	Endothelial	endothelial	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	treated	treat	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	TCP	tcp	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	alpha-tocopherol	alpha-tocopherol	NN	NN	_	9	compound	_	_
9	acetate	acetate	NN	NN	_	6	conj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	TCP	tcp	NN	NN	_	12	compound	_	_
12	acetate	acetate	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	6	punct	_	_
15	or	or	CC	CC	_	6	cc	_	_
16	alpha-tocopheryl	alpha-tocopheryl	NN	NN	_	17	compound	_	_
17	succinate	succinate	NN	NN	_	6	conj	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	TCP	tcp	NN	NN	_	20	compound	_	_
20	succinate	succinate	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	before	before	IN	IN	_	23	case	_	_
23	stimulation	stimulation	NN	NN	_	4	nmod	_	_
24	with	with	IN	IN	_	27	case	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	necrosis	necrosis	NN	NN	_	27	compound	_	_
27	factor-alpha	factor-alpha	NN	NN	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	TNF-alpha	tnf-alpha	NN	NN	_	27	dep	_	_
30	;	;	:	:	_	29	punct	_	_
31	10	10	CD	CD	_	32	nummod	_	_
32	U/ml	u/ml	NN	NN	_	29	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	6	6	CD	CD	_	35	nummod	_	_
35	h	h	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	29	punct	_	_
37	or	or	CC	CC	_	27	cc	_	_
38	interleukin-1	interleukin-1	NN	NN	_	39	compound	_	_
39	beta	beta	NN	NN	_	27	conj	_	_
40	(	(	-LRB-	-LRB-	_	42	punct	_	_
41	IL-1	il-1	NN	NN	_	42	compound	_	_
42	beta	beta	NN	NN	_	39	dep	_	_
43	;	;	:	:	_	42	punct	_	_
44	10	10	CD	CD	_	45	nummod	_	_
45	U/ml	u/ml	NN	NN	_	42	dep	_	_
46	,	,	,	,	_	45	punct	_	_
47	6	6	CD	CD	_	48	nummod	_	_
48	h	h	NN	NN	_	45	appos	_	_
49	)	)	-RRB-	-RRB-	_	42	punct	_	_
50	.	.	.	.	_	4	punct	_	_

1	Cytokine-stimulated	cytokine-stimulated	JJ	JJ	_	4	amod	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	surface	surface	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	40	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	vascular	vascular	JJ	JJ	_	9	amod	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	adhesion	adhesion	NN	NN	_	9	compound	_	_
9	molecule-1	molecule-1	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	VCAM-1	vcam-1	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	CD106	cd106	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	E-selectin	e-selectin	NN	NN	_	9	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ELAM-1	elam-1	NN	NN	_	16	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	CD62E	cd62e	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	,	,	,	,	_	9	punct	_	_
23	but	but	CC	CC	_	9	cc	_	_
24	not	not	RB	RB	_	28	neg	_	_
25	of	of	IN	IN	_	28	case	_	_
26	intercellular	intercellular	JJ	JJ	_	28	amod	_	_
27	adhesion	adhesion	NN	NN	_	28	compound	_	_
28	molecule-1	molecule-1	NN	NN	_	9	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	ICAM-1	icam-1	NN	NN	_	28	dep	_	_
31	,	,	,	,	_	30	punct	_	_
32	CD54	cd54	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	30	punct	_	_
34	,	,	,	,	_	40	punct	_	_
35	was	be	VBD	VBD	_	40	auxpass	_	_
36	time-	time-	NN	NN	_	37	advmod	_	_
37	and	and	CC	CC	_	40	advmod	_	_
38	dose-	dose-	NN	NN	_	37	advmod	_	_
39	dependently	dependently	RB	RB	_	37	advmod	_	_
40	inhibited	inhibit	VBN	VBN	_	0	root	_	_
41	by	by	IN	IN	_	43	case	_	_
42	TCP	tcp	NN	NN	_	43	compound	_	_
43	succinate	succinate	NN	NN	_	40	nmod	_	_
44	but	but	CC	CC	_	43	cc	_	_
45	not	not	RB	RB	_	47	neg	_	_
46	by	by	IN	IN	_	47	case	_	_
47	TCP	tcp	NN	NN	_	43	conj	_	_
48	or	or	CC	CC	_	47	cc	_	_
49	TCP	tcp	NN	NN	_	50	compound	_	_
50	acetate	acetate	NN	NN	_	47	conj	_	_
51	.	.	.	.	_	40	punct	_	_

1	TCP	tcp	NN	NN	_	10	nsubj	_	_
2	succinate	succinate	JJ	JJ	_	1	amod	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	200	200	CD	CD	_	5	nummod	_	_
5	microM	microm	NN	NN	_	1	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	24	24	CD	CD	_	8	nummod	_	_
8	h	h	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	5	punct	_	_
10	reduced	reduce	VBD	VBD	_	0	root	_	_
11	TNF-induced	tnf-induced	JJ	JJ	_	12	amod	_	_
12	VCAM-1	vcam-1	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	E-selectin	e-selectin	NN	NN	_	12	conj	_	_
15	expression	expression	NN	NN	_	12	dep	_	_
16	from	from	IN	IN	_	21	case	_	_
17	a	a	DT	DT	_	21	det	_	_
18	specific	specific	JJ	JJ	_	21	amod	_	_
19	mean	mean	NN	NN	_	21	compound	_	_
20	fluorescence	fluorescence	NN	NN	_	21	compound	_	_
21	intensity	intensity	NN	NN	_	12	dep	_	_
22	of	of	IN	IN	_	23	case	_	_
23	151	151	CD	CD	_	21	nmod	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	28	28	CD	CD	_	23	conj	_	_
26	to	to	TO	TO	_	30	case	_	_
27	12	12	CD	CD	_	30	nummod	_	_
28	+/-	+/-	CC	CC	_	27	cc	_	_
29	4	4	CD	CD	_	27	conj	_	_
30	channels	channel	NNS	NNS	_	21	nmod	_	_
31	and	and	CC	CC	_	21	cc	_	_
32	from	from	IN	IN	_	33	case	_	_
33	225	225	CD	CD	_	21	conj	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	38	38	CD	CD	_	33	conj	_	_
36	to	to	TO	TO	_	40	case	_	_
37	79	79	CD	CD	_	40	nummod	_	_
38	+/-	+/-	CC	CC	_	37	cc	_	_
39	21	21	CD	CD	_	37	conj	_	_
40	channels	channel	NNS	NNS	_	33	nmod	_	_
41	,	,	,	,	_	12	punct	_	_
42	respectively	respectively	RB	RB	_	12	advmod	_	_
43	.	.	.	.	_	10	punct	_	_

1	Succinate	succinate	NN	NN	_	3	nsubj	_	_
2	alone	alone	RB	RB	_	1	advmod	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	no	no	DT	DT	_	5	neg	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	.	.	.	.	_	3	punct	_	_

1	Decreased	decrease	VBN	VBN	_	4	amod	_	_
2	adhesion	adhesion	NN	NN	_	3	compound	_	_
3	molecule	molecule	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	associated	associate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	reduction	reduction	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	adhesion	adhesion	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	TCP	tcp	NN	NN	_	2	compound	_	_
2	succinate	succinate	NN	NN	_	22	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	20	20	CD	CD	_	5	nummod	_	_
5	microM	microm	NN	NN	_	2	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	72	72	CD	CD	_	8	nummod	_	_
8	h	h	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	5	punct	_	_
10	,	,	,	,	_	2	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	2	cc	_	_
13	TCP	tcp	NN	NN	_	2	conj	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	200	200	CD	CD	_	16	nummod	_	_
16	microM	microm	NN	NN	_	13	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	72	72	CD	CD	_	19	nummod	_	_
19	h	h	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	,	,	,	,	_	2	punct	_	_
22	reduced	reduce	VBD	VBD	_	0	root	_	_
23	U-937	u-937	NN	NN	_	24	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	adhesion	adhesion	NN	NN	_	22	dobj	_	_
26	to	to	TO	TO	_	35	case	_	_
27	TNF-alpha-stimulated	tnf-alpha-stimulated	JJ	JJ	_	35	amod	_	_
28	(	(	-LRB-	-LRB-	_	35	punct	_	_
29	10	10	CD	CD	_	35	nummod	_	_
30	U/ml	u/ml	NN	NN	_	35	compound	_	_
31	,	,	,	,	_	35	punct	_	_
32	6	6	CD	CD	_	35	nummod	_	_
33	h	h	NN	NN	_	35	compound	_	_
34	)	)	-RRB-	-RRB-	_	35	punct	_	_
35	HUVEC	huvec	NNS	NNS	_	25	nmod	_	_
36	by	by	IN	IN	_	38	case	_	_
37	30	30	CD	CD	_	38	nummod	_	_
38	%	%	NN	NN	_	22	nmod	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	P	p	NN	NN	_	38	dep	_	_
41	&lt;	&lt;	JJR	JJR	_	40	amod	_	_
42	0.025	0.025	CD	CD	_	41	dep	_	_
43	)	)	-RRB-	-RRB-	_	40	punct	_	_
44	and	and	CC	CC	_	22	cc	_	_
45	to	to	TO	TO	_	48	case	_	_
46	IL-1	il-1	NN	NN	_	48	compound	_	_
47	beta-stimulated	beta-stimulated	JJ	JJ	_	48	amod	_	_
48	HUVEC	huvec	NNS	NNS	_	22	conj	_	_
49	by	by	IN	IN	_	51	case	_	_
50	56	56	CD	CD	_	51	nummod	_	_
51	%	%	NN	NN	_	48	nmod	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	P	p	NN	NN	_	51	dep	_	_
54	&lt;	&lt;	JJR	JJR	_	53	amod	_	_
55	0.010	0.010	CD	CD	_	54	dep	_	_
56	)	)	-RRB-	-RRB-	_	53	punct	_	_
57	.	.	.	.	_	22	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	3	amod	_	_
2	mobility-shift	mobility-shift	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HUVEC	huvec	NNS	NNS	_	3	nmod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	5	dep	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	decrease	decrease	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	20	case	_	_
12	TNF-alpha-stimulated	tnf-alpha-stimulated	JJ	JJ	_	15	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	factor-kappa	factor-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	activation	activation	NN	NN	_	10	nmod	_	_
21	after	after	IN	IN	_	22	case	_	_
22	pretreatment	pretreatment	NN	NN	_	10	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	HUVEC	huvec	NNS	NNS	_	22	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	TCP	tcp	NN	NN	_	27	compound	_	_
27	succinate	succinate	NN	NN	_	22	nmod	_	_
28	but	but	CC	CC	_	27	cc	_	_
29	not	not	RB	RB	_	31	neg	_	_
30	with	with	IN	IN	_	31	case	_	_
31	TCP	tcp	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	31	punct	_	_
33	TCP	tcp	NN	NN	_	34	compound	_	_
34	acetate	acetate	NN	NN	_	31	conj	_	_
35	,	,	,	,	_	31	punct	_	_
36	or	or	CC	CC	_	31	cc	_	_
37	succinate	succinate	NN	NN	_	31	conj	_	_
38	alone	alone	RB	RB	_	31	advmod	_	_
39	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	12	det	_	_
8	vitamin	vitamin	NN	NN	_	12	compound	_	_
9	E	e	NN	NN	_	12	compound	_	_
10	derivative	derivative	NN	NN	_	12	compound	_	_
11	TCP	tcp	NN	NN	_	12	compound	_	_
12	succinate	succinate	NN	NN	_	13	nsubj	_	_
13	prevents	prevent	VBZ	VBZ	_	5	ccomp	_	_
14	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	adhesion	adhesion	NN	NN	_	13	dobj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	cytokine-stimulated	cytokine-stimulated	JJ	JJ	_	20	amod	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	inhibiting	inhibit	VBG	VBG	_	13	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	activation	activation	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	13	punct	_	_
29	further	further	RB	RB	_	30	advmod	_	_
30	emphasizing	emphasize	VBG	VBG	_	13	advcl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	antiatherosclerotic	antiatherosclerotic	JJ	JJ	_	33	amod	_	_
33	potential	potential	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	lipid	lipid	NN	NN	_	37	compound	_	_
36	soluble	soluble	JJ	JJ	_	37	amod	_	_
37	antioxidants	antioxidant	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	inosine-5'-monophosphate	inosine-5'-monophosphate	NN	NN	_	5	compound	_	_
4	dehydrogenase	dehydrogenase	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	8	compound	_	_
6	II	ii	CD	CD	_	5	nummod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	8	case	_	_
3	a	a	DT	DT	_	8	det	_	_
4	novel	novel	JJ	JJ	_	8	amod	_	_
5	5'	5'	JJ	JJ	_	8	amod	_	_
6	palindromic	palindromic	JJ	JJ	_	8	amod	_	_
7	octamer	octamer	NN	NN	_	8	compound	_	_
8	sequence	sequence	NN	NN	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Expression	expression	NN	NN	_	29	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	gene	gene	NN	NN	_	1	nmod	_	_
5	encoding	encode	VBG	VBG	_	4	acl	_	_
6	human	human	JJ	JJ	_	12	amod	_	_
7	inosine-5'-monophosphate	inosine-5'-monophosphate	NN	NN	_	12	compound	_	_
8	dehydrogenase	dehydrogenase	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	IMPDH	impdh	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	type	type	NN	NN	_	5	dobj	_	_
13	II	ii	CD	CD	_	12	nummod	_	_
14	,	,	,	,	_	12	punct	_	_
15	an	a	DT	DT	_	16	det	_	_
16	enzyme	enzyme	NN	NN	_	12	appos	_	_
17	catalyzing	catalyze	VBG	VBG	_	16	acl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	rate-limiting	rate-limiting	JJ	JJ	_	20	amod	_	_
20	step	step	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	generation	generation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	guanine	guanine	NN	NN	_	26	compound	_	_
26	nucleotides	nucleotide	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	1	punct	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	increased	increase	VBN	VBN	_	0	root	_	_
30	more	more	JJR	JJR	_	29	dobj	_	_
31	than	than	IN	IN	_	30	amod	_	_
32	10-fold	10-fold	RB	RB	_	30	advmod	_	_
33	in	in	IN	IN	_	38	case	_	_
34	activated	activate	VBN	VBN	_	38	amod	_	_
35	peripheral	peripheral	JJ	JJ	_	38	amod	_	_
36	blood	blood	NN	NN	_	38	compound	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	lymphocytes	lymphocyte	NNS	NNS	_	29	nmod	_	_
39	and	and	CC	CC	_	29	cc	_	_
40	is	be	VBZ	VBZ	_	41	auxpass	_	_
41	required	require	VBN	VBN	_	29	conj	_	_
42	for	for	IN	IN	_	45	case	_	_
43	T	t	NN	NN	_	45	compound	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	activation	activation	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	29	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	5'-regulatory	5'-regulatory	JJ	JJ	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	3	dobj	_	_
7	that	that	WDT	WDT	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	important	important	JJ	JJ	_	6	acl:relcl	_	_
10	for	for	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	gene	gene	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	DNase	dnase	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	1	nummod	_	_
3	mapping	mapping	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	genomic	genomic	JJ	JJ	_	6	amod	_	_
6	DNA	dna	NN	NN	_	3	nmod	_	_
7	identified	identify	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	hypersensitive	hypersensitive	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	7	dobj	_	_
11	near	near	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	initiation	initiation	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Fine	fine	JJ	JJ	_	2	amod	_	_
2	mapping	mapping	NN	NN	_	7	nsubj	_	_
3	by	by	IN	IN	_	6	case	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	vivo	vivo	FW	FW	_	4	dep	_	_
6	footprinting	footprinting	NN	NN	_	2	nmod	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	five	five	CD	CD	_	12	nummod	_	_
9	transcription	transcription	NN	NN	_	12	compound	_	_
10	factor	factor	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	7	dobj	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	occupied	occupy	VBN	VBN	_	12	acl:relcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	resting	rest	VBG	VBG	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	activated	activate	VBN	VBN	_	24	amod	_	_
21	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
22	blood	blood	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	18	conj	_	_
25	;	;	:	:	_	7	punct	_	_
26	these	these	DT	DT	_	30	nsubj	_	_
27	are	be	VBP	VBP	_	30	cop	_	_
28	tandem	tandem	JJ	JJ	_	30	amod	_	_
29	CRE	cre	NN	NN	_	30	compound	_	_
30	motifs	motif	NNS	NNS	_	7	parataxis	_	_
31	,	,	,	,	_	30	punct	_	_
32	a	a	DT	DT	_	34	det	_	_
33	Sp1	sp1	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	30	conj	_	_
35	,	,	,	,	_	30	punct	_	_
36	an	a	DT	DT	_	39	det	_	_
37	overlapping	overlapping	JJ	JJ	_	39	amod	_	_
38	Egr-1/Sp1	egr-1/sp1	NN	NN	_	39	compound	_	_
39	site	site	NN	NN	_	30	conj	_	_
40	,	,	,	,	_	30	punct	_	_
41	and	and	CC	CC	_	30	cc	_	_
42	a	a	DT	DT	_	46	det	_	_
43	novel	novel	JJ	JJ	_	46	amod	_	_
44	palindromic	palindromic	JJ	JJ	_	46	amod	_	_
45	octamer	octamer	NN	NN	_	46	compound	_	_
46	sequence	sequence	NN	NN	_	30	conj	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	POS	pos	NN	NN	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	dep	_	_
2	tandem	tandem	JJ	JJ	_	3	amod	_	_
3	CRE	cre	NN	NN	_	11	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	POS	pos	NN	NN	_	3	conj	_	_
6	sites	site	NNS	NNS	_	3	dep	_	_
7	are	be	VBP	VBP	_	11	cop	_	_
8	of	of	IN	IN	_	11	case	_	_
9	major	major	JJ	JJ	_	11	amod	_	_
10	functional	functional	JJ	JJ	_	9	dep	_	_
11	importance	importance	NN	NN	_	0	root	_	_
12	as	as	IN	IN	_	13	mark	_	_
13	judged	judge	VBN	VBN	_	11	advcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	mutational	mutational	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	electrophoretic	electrophoretic	JJ	JJ	_	15	conj	_	_
18	mobility	mobility	NN	NN	_	20	compound	_	_
19	shift	shift	NN	NN	_	20	compound	_	_
20	analyses	analysis	NNS	NNS	_	15	dep	_	_
21	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	expression	expression	NN	NN	_	16	nsubjpass	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	IMPDH	impdh	NN	NN	_	13	compound	_	_
11	type	type	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	gene	gene	NN	NN	_	6	nmod	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	predominantly	predominantly	RB	RB	_	16	advmod	_	_
16	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
17	by	by	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	factors	factor	NNS	NNS	_	16	nmod	_	_
21	ATF-2	atf-2	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	an	a	DT	DT	_	28	det	_	_
24	as	as	RB	RB	_	25	advmod	_	_
25	yet	yet	RB	RB	_	26	advmod	_	_
26	unidentified	unidentified	JJ	JJ	_	28	amod	_	_
27	POS-binding	pos-binding	JJ	JJ	_	28	amod	_	_
28	protein	protein	NN	NN	_	20	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Additional	additional	JJ	JJ	_	4	amod	_	_
2	major	major	JJ	JJ	_	1	dep	_	_
3	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
4	interactions	interaction	NNS	NNS	_	7	nsubj	_	_
5	do	do	VBP	VBP	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	occur	occur	VB	VB	_	0	root	_	_
8	within	within	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	7	nmod	_	_
12	after	after	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	7	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	indicating	indicate	VBG	VBG	_	7	advcl	_	_
18	a	a	DT	DT	_	19	det	_	_
19	requirement	requirement	NN	NN	_	17	dobj	_	_
20	for	for	IN	IN	_	23	case	_	_
21	additional	additional	JJ	JJ	_	23	amod	_	_
22	protein-protein	protein-protein	JJ	JJ	_	23	amod	_	_
23	interactions	interaction	NNS	NNS	_	19	nmod	_	_
24	and/or	and/or	CC	CC	_	23	cc	_	_
25	post-translational	post-translational	JJ	JJ	_	26	amod	_	_
26	modifications	modification	NNS	NNS	_	23	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	pre-bound	pre-bound	JJ	JJ	_	30	amod	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	26	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	account	account	VB	VB	_	19	acl	_	_
33	for	for	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	observed	observe	VBN	VBN	_	36	amod	_	_
36	increase	increase	NN	NN	_	32	nmod	_	_
37	in	in	IN	IN	_	42	case	_	_
38	IMPDH	impdh	NN	NN	_	42	compound	_	_
39	type	type	NN	NN	_	42	compound	_	_
40	II	ii	CD	CD	_	42	nummod	_	_
41	gene	gene	NN	NN	_	42	compound	_	_
42	expression	expression	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	during	during	IN	IN	_	4	case	_	_
4	myelopoiesis	myelopoiesis	NN	NN	_	2	nmod	_	_
5	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	coordinated	coordinate	VBN	VBN	_	3	amod	_	_
3	production	production	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	all	all	DT	DT	_	7	det	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	from	from	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	common	common	JJ	JJ	_	12	amod	_	_
11	stem	stem	NN	NN	_	12	compound	_	_
12	cell	cell	NN	NN	_	3	nmod	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	a	a	DT	DT	_	17	det	_	_
15	highly	highly	RB	RB	_	16	advmod	_	_
16	regulated	regulate	VBN	VBN	_	17	amod	_	_
17	process	process	NN	NN	_	0	root	_	_
18	involving	involve	VBG	VBG	_	17	acl	_	_
19	successive	successive	JJ	JJ	_	20	amod	_	_
20	stages	stage	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	commitment	commitment	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	differentiation	differentiation	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	From	from	IN	IN	_	2	case	_	_
2	analyses	analysis	NNS	NNS	_	23	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	mice	mouse	NNS	NNS	_	2	nmod	_	_
5	deficient	deficient	JJ	JJ	_	4	amod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	from	from	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	characterizations	characterization	NNS	NNS	_	2	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	chromosome	chromosome	NN	NN	_	16	compound	_	_
16	breakpoints	breakpoint	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	leukemias	leukemia	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	it	it	PRP	PRP	_	23	nsubj	_	_
22	has	have	VBZ	VBZ	_	23	aux	_	_
23	become	become	VBN	VBN	_	0	root	_	_
24	evident	evident	JJ	JJ	_	23	xcomp	_	_
25	that	that	IN	IN	_	30	mark	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	30	nsubj	_	_
28	are	be	VBP	VBP	_	30	cop	_	_
29	important	important	JJ	JJ	_	30	amod	_	_
30	regulators	regulator	NNS	NNS	_	23	ccomp	_	_
31	of	of	IN	IN	_	32	case	_	_
32	hematopoiesis	hematopoiesis	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	23	punct	_	_

1	During	during	IN	IN	_	2	case	_	_
2	myelopoiesis	myelopoiesis	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	includes	include	VBZ	VBZ	_	2	acl:relcl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	development	development	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	granulocytic	granulocytic	JJ	JJ	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	monocytic	monocytic	JJ	JJ	_	9	conj	_	_
12	lineages	lineage	NNS	NNS	_	9	dep	_	_
13	,	,	,	,	_	20	punct	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	20	nsubj	_	_
16	from	from	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	families	family	NNS	NNS	_	15	nmod	_	_
19	are	be	VBP	VBP	_	20	cop	_	_
20	active	active	JJ	JJ	_	0	root	_	_
21	,	,	,	,	_	20	punct	_	_
22	including	include	VBG	VBG	_	24	case	_	_
23	AML1/CBF	aml1/cbf	NN	NN	_	24	compound	_	_
24	beta	beta	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	C/EBP	c/ebp	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	Ets	ets	NN	NN	_	24	conj	_	_
29	,	,	,	,	_	24	punct	_	_
30	c-Myb	c-myb	NN	NN	_	24	conj	_	_
31	,	,	,	,	_	24	punct	_	_
32	HOX	hox	NN	NN	_	24	conj	_	_
33	,	,	,	,	_	24	punct	_	_
34	and	and	CC	CC	_	24	cc	_	_
35	MZF-1	mzf-1	NN	NN	_	24	conj	_	_
36	.	.	.	.	_	20	punct	_	_

1	Few	few	JJ	JJ	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	exclusively	exclusively	RB	RB	_	10	advmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	;	;	:	:	_	6	punct	_	_
12	instead	instead	RB	RB	_	14	advmod	_	_
13	it	it	PRP	PRP	_	14	nsubj	_	_
14	appears	appear	VBZ	VBZ	_	6	parataxis	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	they	they	PRP	PRP	_	18	nsubj	_	_
17	cooperatively	cooperatively	RB	RB	_	18	advmod	_	_
18	regulate	regulate	VBP	VBP	_	14	ccomp	_	_
19	transcription	transcription	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	myeloid-specific	myeloid-specific	JJ	JJ	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	discuss	discuss	VBP	VBP	_	0	root	_	_
4	recent	recent	JJ	JJ	_	5	amod	_	_
5	advances	advance	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	during	during	IN	IN	_	10	case	_	_
10	myelopoiesis	myelopoiesis	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	Egr-1	egr-1	NN	NN	_	2	dep	_	_
4	activity	activity	NN	NN	_	5	nsubj	_	_
5	down-regulates	down-regulate	VBZ	VBZ	_	0	root	_	_
6	Fas	fas	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CD23	cd23	NN	NN	_	6	conj	_	_
9	expression	expression	NN	NN	_	6	dep	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	mature	mature	JJ	JJ	_	5	amod	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	via	via	IN	IN	_	9	case	_	_
7	Ag	ag	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	cross-linking	cross-linking	NN	NN	_	1	nmod	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	transient	transient	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	12	nmod	_	_
17	Egr-1	egr-1	NN	NN	_	16	dep	_	_
18	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	11	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	activating	activate	VBG	VBG	_	4	amod	_	_
4	signals	signal	NNS	NNS	_	11	nsubjpass	_	_
5	leading	lead	VBG	VBG	_	4	acl	_	_
6	to	to	TO	TO	_	8	case	_	_
7	Egr-1	egr-1	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	5	nmod	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	studied	study	VBN	VBN	_	16	advcl	_	_
12	extensively	extensively	RB	RB	_	11	advmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	little	little	JJ	JJ	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	known	know	VBN	VBN	_	0	root	_	_
17	about	about	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	that	that	WDT	WDT	_	22	nsubjpass	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	placed	place	VBN	VBN	_	19	acl:relcl	_	_
23	further	further	RBR	RBR	_	24	advmod	_	_
24	downstream	downstream	RB	RB	_	22	advmod	_	_
25	within	within	IN	IN	_	28	case	_	_
26	this	this	DT	DT	_	28	det	_	_
27	activation	activation	NN	NN	_	28	compound	_	_
28	cascade	cascade	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	that	that	WDT	WDT	_	33	nsubjpass	_	_
31	are	be	VBP	VBP	_	33	auxpass	_	_
32	transcriptionally	transcriptionally	RB	RB	_	33	advmod	_	_
33	regulated	regulate	VBN	VBN	_	22	conj	_	_
34	by	by	IN	IN	_	35	case	_	_
35	Egr-1	egr-1	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	such	such	JJ	JJ	_	5	amod	_	_
4	target	target	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	established	establish	VBD	VBD	_	2	parataxis	_	_
9	Egr-1-overexpressing	egr-1-overexpressing	JJ	JJ	_	10	amod	_	_
10	transfectants	transfectant	NNS	NNS	_	8	dobj	_	_
11	from	from	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	murine	murine	JJ	JJ	_	17	amod	_	_
14	B	b	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	line	line	NN	NN	_	17	compound	_	_
17	K46	k46	NN	NN	_	8	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	from	from	IN	IN	_	23	case	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	Ramos	ramos	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	clones	clone	NNS	NNS	_	8	nsubj	_	_
3	derived	derive	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	7	case	_	_
5	K46	k46	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CD44	cd44	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Most	most	RBS	RBS	_	2	advmod	_	_
2	interestingly	interestingly	RB	RB	_	14	advmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	expression	expression	NN	NN	_	14	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CD95	cd95	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Fas/Apo-1	fas/apo-1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CD23	cd23	NN	NN	_	6	conj	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	all	all	DT	DT	_	18	det	_	_
17	K46	k46	NN	NN	_	18	compound	_	_
18	transfectants	transfectant	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	consequence	consequence	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	they	they	PRP	PRP	_	6	nsubj	_	_
6	became	become	VBD	VBD	_	0	root	_	_
7	resistant	resistant	JJ	JJ	_	6	xcomp	_	_
8	to	to	TO	TO	_	9	case	_	_
9	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
10	induced	induce	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	anti-CD95	anti-cd95	JJ	JJ	_	13	amod	_	_
13	Ab	ab	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Similarly	similarly	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	Egr-1-expressing	egr-1-expressing	JJ	JJ	_	6	amod	_	_
5	Ramos	ramos	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	reduced	reduce	VBN	VBN	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	CD95	cd95	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Egr-1	egr-1	NN	NN	_	4	nsubj	_	_
4	seems	seem	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	control	control	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	downstream	downstream	JJ	JJ	_	12	amod	_	_
11	target	target	NN	NN	_	12	compound	_	_
12	genes	gene	NNS	NNS	_	8	nmod	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	only	only	RB	RB	_	18	cc:preconj	_	_
15	as	as	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activator	activator	NN	NN	_	6	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	but	but	CC	CC	_	18	cc	_	_
21	also	also	RB	RB	_	25	advmod	_	_
22	as	as	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	repressor	repressor	NN	NN	_	25	compound	_	_
25	molecule	molecule	NN	NN	_	18	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	Egr-1	egr-1	NN	NN	_	7	nsubj	_	_
6	therefore	therefore	RB	RB	_	7	advmod	_	_
7	plays	play	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	critical	critical	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	integrating	integrate	VBG	VBG	_	7	advcl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	short-lived	short-lived	JJ	JJ	_	15	amod	_	_
15	signal	signal	NN	NN	_	12	dobj	_	_
16	delivered	deliver	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	triggering	triggering	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	Ag	ag	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	18	nmod	_	_
23	into	into	IN	IN	_	25	case	_	_
24	phenotypic	phenotypic	JJ	JJ	_	25	amod	_	_
25	changes	change	NNS	NNS	_	12	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	including	include	VBG	VBG	_	28	case	_	_
28	repression	repression	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	CD95	cd95	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	CD23	cd23	NN	NN	_	33	compound	_	_
33	transcription	transcription	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	7	punct	_	_

1	Genomic	genomic	JJ	JJ	_	2	amod	_	_
2	organization	organization	NN	NN	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	sequence	sequence	NN	NN	_	2	appos	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	eotaxin	eotaxin	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Eotaxin	eotaxin	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	eosinophil	eosinophil	NN	NN	_	6	compound	_	_
5	specific	specific	JJ	JJ	_	6	amod	_	_
6	beta-chemokine	beta-chemokine	NN	NN	_	0	root	_	_
7	assumed	assume	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	7	xcomp	_	_
11	in	in	IN	IN	_	14	case	_	_
12	eosinophilic	eosinophilic	JJ	JJ	_	14	amod	_	_
13	inflammatory	inflammatory	JJ	JJ	_	12	dep	_	_
14	diseases	disease	NNS	NNS	_	10	nmod	_	_
15	such	such	JJ	JJ	_	18	case	_	_
16	as	as	IN	IN	_	15	mwe	_	_
17	atopic	atopic	JJ	JJ	_	18	amod	_	_
18	dermatitis	dermatitis	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	allergic	allergic	JJ	JJ	_	21	amod	_	_
21	rhinitis	rhinitis	NN	NN	_	18	conj	_	_
22	,	,	,	,	_	18	punct	_	_
23	asthma	asthma	NN	NN	_	18	conj	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	parasitic	parasitic	JJ	JJ	_	26	amod	_	_
26	infections	infection	NNS	NNS	_	18	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	expression	expression	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	stimulus-	stimulus-	NN	NN	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cell-specific	cell-specific	JJ	JJ	_	4	conj	_	_
7	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	here	here	RB	RB	_	3	advmod	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	dep	_	_
5	genomic	genomic	JJ	JJ	_	6	amod	_	_
6	organisation	organisation	NN	NN	_	3	dobj	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	3	3	CD	CD	_	9	nummod	_	_
9	exons	exon	NNS	NNS	_	6	dep	_	_
10	of	of	IN	IN	_	11	case	_	_
11	132	132	CD	CD	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	112	112	CD	CD	_	11	conj	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	542	542	CD	CD	_	11	conj	_	_
16	bp	bp	NN	NN	_	11	dep	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	2	2	CD	CD	_	19	nummod	_	_
19	introns	intron	NNS	NNS	_	9	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	1211	1211	CD	CD	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	378	378	CD	CD	_	21	conj	_	_
24	bp	bp	NN	NN	_	21	dep	_	_
25	)	)	-RRB-	-RRB-	_	9	punct	_	_
26	and	and	CC	CC	_	6	cc	_	_
27	sequence	sequence	NN	NN	_	6	conj	_	_
28	including	include	VBG	VBG	_	30	case	_	_
29	3	3	CD	CD	_	30	nummod	_	_
30	kb	kb	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	DNA	dna	NN	NN	_	30	nmod	_	_
33	from	from	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	immediate	immediate	JJ	JJ	_	38	amod	_	_
36	5'	5'	JJ	JJ	_	38	amod	_	_
37	upstream	upstream	JJ	JJ	_	38	amod	_	_
38	region	region	NN	NN	_	30	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	the	the	DT	DT	_	43	det	_	_
41	human	human	JJ	JJ	_	43	amod	_	_
42	eotaxin	eotaxin	NN	NN	_	43	compound	_	_
43	gene	gene	NN	NN	_	38	nmod	_	_
44	.	.	.	.	_	3	punct	_	_

1	Among	among	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	elements	element	NNS	NNS	_	19	nmod	_	_
6	potentially	potentially	RB	RB	_	7	advmod	_	_
7	regulating	regulate	VBG	VBG	_	5	dep	_	_
8	eotaxin	eotaxin	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	and/or	and/or	CC	CC	_	7	cc	_	_
12	mediating	mediate	VBG	VBG	_	7	conj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effects	effect	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	anti-inflammatory	anti-inflammatory	JJ	JJ	_	17	amod	_	_
17	drugs	drug	NNS	NNS	_	14	nmod	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	identified	identify	VBD	VBD	_	0	root	_	_
20	consensus	consensus	NN	NN	_	21	compound	_	_
21	sequences	sequence	NNS	NNS	_	19	dobj	_	_
22	known	know	VBN	VBN	_	21	acl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	interact	interact	VB	VB	_	22	xcomp	_	_
25	with	with	IN	IN	_	27	case	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	like	like	IN	IN	_	29	case	_	_
29	NF-IL6	nf-il6	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	AP-1	ap-1	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	a	a	DT	DT	_	37	det	_	_
34	NF-kappa-B	nf-kappa-b	NN	NN	_	37	compound	_	_
35	like	like	JJ	JJ	_	37	amod	_	_
36	consensus	consensus	NN	NN	_	37	compound	_	_
37	sequence	sequence	NN	NN	_	29	conj	_	_
38	and	and	CC	CC	_	29	cc	_	_
39	gamma-interferon-	gamma-interferon-	NN	NN	_	29	conj	_	_
40	as	as	RB	RB	_	39	cc	_	_
41	well	well	RB	RB	_	40	mwe	_	_
42	as	as	IN	IN	_	40	mwe	_	_
43	glucocorticoid	glucocorticoid	NN	NN	_	39	conj	_	_
44	response	response	NN	NN	_	45	compound	_	_
45	elements	element	NNS	NNS	_	39	dep	_	_
46	.	.	.	.	_	19	punct	_	_

1	Vitamin	vitamin	NN	NN	_	3	compound	_	_
2	D	d	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	evidence	evidence	NN	NN	_	3	dep	_	_
7	for	for	IN	IN	_	10	case	_	_
8	allele-specific	allele-specific	JJ	JJ	_	10	amod	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	stability	stability	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	heterozygous	heterozygous	JJ	JJ	_	12	acl:relcl	_	_
16	for	for	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	Taq	taq	NN	NN	_	21	compound	_	_
19	I	i	NN	NN	_	21	compound	_	_
20	restriction	restriction	NN	NN	_	21	compound	_	_
21	enzyme	enzyme	NN	NN	_	22	compound	_	_
22	polymorphism	polymorphism	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Allelic	allelic	JJ	JJ	_	2	amod	_	_
2	variations	variation	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	vitamin	vitamin	NN	NN	_	11	compound	_	_
6	D	d	NN	NN	_	11	compound	_	_
7	receptor	receptor	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	VDR	vdr	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	gene	gene	NN	NN	_	2	nmod	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	risk	risk	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	developing	develop	VBG	VBG	_	17	acl	_	_
20	prostate	prostate	NN	NN	_	21	compound	_	_
21	cancer	cancer	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	men	man	NNS	NNS	_	21	nmod	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	osteoporosis	osteoporosis	NN	NN	_	19	conj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	postmenopausal	postmenopausal	JJ	JJ	_	28	amod	_	_
28	women	woman	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	Three	three	CD	CD	_	2	nummod	_	_
2	RFLPs	rflp	NNS	NNS	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	TaqI	taqi	NN	NN	_	2	dep	_	_
5	,	,	,	,	_	4	punct	_	_
6	ApaI	apai	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	BsmI	bsmi	NN	NN	_	4	appos	_	_
9	)	)	-RRB-	-RRB-	_	4	punct	_	_
10	define	define	VBP	VBP	_	0	root	_	_
11	two	two	CD	CD	_	13	nummod	_	_
12	common	common	JJ	JJ	_	13	amod	_	_
13	haplotypes	haplotype	NNS	NNS	_	10	dobj	_	_
14	:	:	:	:	_	10	punct	_	_
15	BAt	bat	NN	NN	_	10	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	baT	bat	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	10	punct	_	_

1	None	none	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	polymorphisms	polymorphism	NNS	NNS	_	1	nmod	_	_
5	change	change	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	translated	translate	VBN	VBN	_	8	amod	_	_
8	protein	protein	NN	NN	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	Since	since	IN	IN	_	12	mark	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	variations	variation	NNS	NNS	_	12	nsubjpass	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	3'	3'	JJ	JJ	_	7	amod	_	_
7	UTR	utr	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	VDR	vdr	NN	NN	_	7	nmod	_	_
10	have	have	VBP	VBP	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	linked	link	VBN	VBN	_	20	advcl	_	_
13	to	to	TO	TO	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	different	different	JJ	JJ	_	16	amod	_	_
16	haplotypes	haplotype	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	investigators	investigator	NNS	NNS	_	20	nsubj	_	_
19	have	have	VBP	VBP	_	20	aux	_	_
20	proposed	propose	VBN	VBN	_	0	root	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	the	the	DT	DT	_	23	det	_	_
23	stability	stability	NN	NN	_	28	nsubjpass	_	_
24	of	of	IN	IN	_	26	case	_	_
25	VDR	vdr	NN	NN	_	26	compound	_	_
26	mRNA	mrna	NN	NN	_	23	nmod	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	influenced	influence	VBN	VBN	_	20	ccomp	_	_
29	by	by	IN	IN	_	31	case	_	_
30	allelic	allelic	JJ	JJ	_	31	amod	_	_
31	variations	variation	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	20	punct	_	_

1	Indirect	indirect	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	allele	allele	NN	NN	_	6	compound	_	_
6	T	t	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	less	less	RBR	RBR	_	9	advmod	_	_
9	stable	stable	JJ	JJ	_	3	ccomp	_	_
10	than	than	IN	IN	_	12	case	_	_
11	allele	allele	NN	NN	_	12	compound	_	_
12	t	t	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	used	use	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	RT-PCR	rt-pcr	NN	NN	_	10	compound	_	_
9	based	based	JJ	JJ	_	10	amod	_	_
10	approach	approach	NN	NN	_	6	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	compare	compare	VB	VB	_	6	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	stability	stability	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	dep	_	_
17	big	big	JJ	JJ	_	18	amod	_	_
18	T	t	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	small	small	JJ	JJ	_	21	amod	_	_
21	t	t	NN	NN	_	18	conj	_	_
22	allele	allele	NN	NN	_	18	dep	_	_
23	in	in	IN	IN	_	26	case	_	_
24	normal	normal	JJ	JJ	_	26	amod	_	_
25	heterozygous	heterozygous	JJ	JJ	_	26	amod	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	the	the	DT	DT	_	31	det	_	_
29	heterozygous	heterozygous	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	lines	line	NNS	NNS	_	26	conj	_	_
32	NB4	nb4	NN	NN	_	31	dep	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	myeloid	myeloid	JJ	JJ	_	35	amod	_	_
35	leukemia	leukemia	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	and	and	CC	CC	_	32	cc	_	_
38	PC-3	pc-3	NN	NN	_	32	conj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	DU	du	NN	NN	_	38	conj	_	_
41	145	145	CD	CD	_	40	nummod	_	_
42	(	(	-LRB-	-LRB-	_	44	punct	_	_
43	prostate	prostate	NN	NN	_	44	compound	_	_
44	cancers	cancer	NNS	NNS	_	38	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	all	all	DT	DT	_	4	det	_	_
3	three	three	CD	CD	_	4	nummod	_	_
4	cases	case	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	we	we	PRP	PRP	_	9	nsubj	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	find	find	VB	VB	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	significant	significant	JJ	JJ	_	12	amod	_	_
12	difference	difference	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	stability	stability	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Interestingly	interestingly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	consistently	consistently	RB	RB	_	5	advmod	_	_
5	observed	observe	VBD	VBD	_	0	root	_	_
6	30	30	CD	CD	_	7	nummod	_	_
7	%	%	NN	NN	_	8	nmod:npmod	_	_
8	less	less	JJR	JJR	_	10	amod	_	_
9	RT-PCR	rt-pcr	NN	NN	_	10	compound	_	_
10	product	product	NN	NN	_	5	dobj	_	_
11	derived	derive	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	small	small	JJ	JJ	_	17	amod	_	_
15	t	t	NN	NN	_	17	compound	_	_
16	allele	allele	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	11	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	steady	steady	JJ	JJ	_	20	amod	_	_
20	state	state	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	a	a	DT	DT	_	23	det	_	_
23	finding	finding	NN	NN	_	5	dep	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	speaks	speak	VBZ	VBZ	_	23	acl:relcl	_	_
27	against	against	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	higher	higher	JJR	JJR	_	30	amod	_	_
30	stability	stability	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	small	small	JJ	JJ	_	36	amod	_	_
34	t	t	NN	NN	_	36	compound	_	_
35	allele	allele	NN	NN	_	36	compound	_	_
36	mRNA	mrna	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	variation	variation	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	rather	rather	RB	RB	_	5	cc	_	_
10	than	than	IN	IN	_	9	mwe	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	stability	stability	NN	NN	_	5	conj	_	_
13	between	between	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	alleles	allele	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesize	hypothesize	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	an	a	DT	DT	_	6	det	_	_
5	unknown	unknown	JJ	JJ	_	6	amod	_	_
6	gene	gene	NN	NN	_	14	nsubj	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	genes	gene	NNS	NNS	_	6	conj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	linkage	linkage	NN	NN	_	6	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	polymorphisms	polymorphism	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	2	ccomp	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	are	be	VBP	VBP	_	14	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	responsible	responsible	JJ	JJ	_	14	xcomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	relationship	relationship	NN	NN	_	18	nmod	_	_
22	between	between	IN	IN	_	23	case	_	_
23	risk	risk	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	prostate	prostate	NN	NN	_	26	compound	_	_
26	cancer	cancer	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	VDR	vdr	NN	NN	_	23	conj	_	_
29	polymorphisms	polymorphism	NNS	NNS	_	28	dep	_	_
30	.	.	.	.	_	2	punct	_	_

1	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	0	root	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	2	dep	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	control	control	NN	NN	_	2	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	process	process	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	eliminate	eliminate	VB	VB	_	6	xcomp	_	_
9	unwanted	unwanted	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	8	dobj	_	_
11	from	from	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	wide	wide	JJ	JJ	_	14	amod	_	_
14	variety	variety	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	organisms	organism	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Various	various	JJ	JJ	_	3	amod	_	_
2	extracellular	extracellular	JJ	JJ	_	3	amod	_	_
3	signals	signal	NNS	NNS	_	13	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	often	often	RB	RB	_	6	advmod	_	_
6	converging	converge	VBG	VBG	_	3	acl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	common	common	JJ	JJ	_	10	amod	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	pathways	pathway	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	induce	induce	VB	VB	_	0	root	_	_
14	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	cell-type-specific	cell-type-specific	JJ	JJ	_	18	amod	_	_
18	fashion	fashion	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	work	work	NN	NN	_	7	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	several	several	JJ	JJ	_	5	amod	_	_
5	laboratories	laboratory	NNS	NNS	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	7	aux	_	_
7	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	13	nsubj	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	10	dep	_	_
13	regulate	regulate	VBP	VBP	_	7	ccomp	_	_
14	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	many	many	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	most	most	JJS	JJS	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	9	nsubj	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	6	dep	_	_
9	appear	appear	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	mediate	mediate	VB	VB	_	9	xcomp	_	_
12	survival	survival	JJ	JJ	_	13	amod	_	_
13	signals	signal	NNS	NNS	_	11	dobj	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	protect	protect	VBP	VBP	_	13	acl:relcl	_	_
16	cells	cell	NNS	NNS	_	15	dobj	_	_
17	from	from	IN	IN	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	15	nmod	_	_
19	;	;	:	:	_	9	punct	_	_
20	however	however	RB	RB	_	32	advmod	_	_
21	,	,	,	,	_	32	punct	_	_
22	under	under	IN	IN	_	24	case	_	_
23	some	some	DT	DT	_	24	det	_	_
24	circumstances	circumstance	NNS	NNS	_	32	nmod	_	_
25	,	,	,	,	_	32	punct	_	_
26	activation	activation	NN	NN	_	32	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	these	these	DT	DT	_	29	det	_	_
29	factors	factor	NNS	NNS	_	26	nmod	_	_
30	may	may	MD	MD	_	32	aux	_	_
31	also	also	RB	RB	_	32	advmod	_	_
32	promote	promote	VB	VB	_	9	parataxis	_	_
33	apoptosis	apoptosis	NN	NN	_	32	dobj	_	_
34	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	viral	viral	JJ	JJ	_	9	amod	_	_
9	oncogenesis	oncogenesis	NN	NN	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	regulation	regulation	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	viral	viral	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	ubiquitous	ubiquitous	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	consists	consist	VBZ	VBZ	_	7	acl:relcl	_	_
10	of	of	IN	IN	_	13	case	_	_
11	multiple	multiple	JJ	JJ	_	13	amod	_	_
12	polypeptide	polypeptide	NN	NN	_	13	compound	_	_
13	subunits	subunit	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	subject	subject	JJ	JJ	_	7	conj	_	_
18	to	to	TO	TO	_	21	case	_	_
19	complex	complex	JJ	JJ	_	21	amod	_	_
20	regulatory	regulatory	JJ	JJ	_	21	amod	_	_
21	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	involve	involve	VBP	VBP	_	21	acl:relcl	_	_
24	protein-protein	protein-protein	JJ	JJ	_	25	amod	_	_
25	interactions	interaction	NNS	NNS	_	23	dobj	_	_
26	,	,	,	,	_	25	punct	_	_
27	phosphorylation	phosphorylation	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	ubiquitination	ubiquitination	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	proteolytic	proteolytic	JJ	JJ	_	32	amod	_	_
32	degradation	degradation	NN	NN	_	25	conj	_	_
33	,	,	,	,	_	25	punct	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	nucleocytoplasmic	nucleocytoplasmic	JJ	JJ	_	36	amod	_	_
36	translocation	translocation	NN	NN	_	25	conj	_	_
37	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	sophisticated	sophisticated	JJ	JJ	_	3	amod	_	_
3	control	control	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	surprising	surprising	JJ	JJ	_	0	root	_	_
11	since	since	IN	IN	_	16	mark	_	_
12	this	this	DT	DT	_	14	det	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	10	advcl	_	_
17	in	in	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	wide	wide	JJ	JJ	_	20	amod	_	_
20	array	array	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	cellular	cellular	JJ	JJ	_	23	amod	_	_
23	responses	response	NNS	NNS	_	20	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	extracellular	extracellular	JJ	JJ	_	26	amod	_	_
26	cues	cue	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	associated	associate	VBN	VBN	_	20	acl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	growth	growth	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	development	development	NN	NN	_	30	conj	_	_
33	,	,	,	,	_	30	punct	_	_
34	apoptosis	apoptosis	NN	NN	_	30	conj	_	_
35	,	,	,	,	_	30	punct	_	_
36	and	and	CC	CC	_	30	cc	_	_
37	pathogen	pathogen	NN	NN	_	38	compound	_	_
38	invasion	invasion	NN	NN	_	30	conj	_	_
39	.	.	.	.	_	10	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	unexpected	unexpected	JJ	JJ	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	this	this	DT	DT	_	12	det	_	_
9	versatile	versatile	JJ	JJ	_	12	amod	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	homeostatic	homeostatic	JJ	JJ	_	9	dep	_	_
12	switch	switch	NN	NN	_	15	nsubjpass	_	_
13	would	would	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	affected	affect	VBN	VBN	_	6	ccomp	_	_
16	by	by	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	variety	variety	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	viral	viral	JJ	JJ	_	21	amod	_	_
21	pathogens	pathogen	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	which	which	WDT	WDT	_	25	nsubj	_	_
24	have	have	VBP	VBP	_	25	aux	_	_
25	evolved	evolve	VBN	VBN	_	21	acl:relcl	_	_
26	mechanisms	mechanism	NNS	NNS	_	25	dobj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	utilize	utilize	VB	VB	_	26	acl	_	_
29	various	various	JJ	JJ	_	30	amod	_	_
30	aspects	aspect	NNS	NNS	_	28	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	activity	activity	NN	NN	_	30	nmod	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	facilitate	facilitate	VB	VB	_	25	xcomp	_	_
37	their	they	PRP$	PRP$	_	38	nmod:poss	_	_
38	replication	replication	NN	NN	_	36	dobj	_	_
39	,	,	,	,	_	38	punct	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	survival	survival	NN	NN	_	38	conj	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	possibly	possibly	RB	RB	_	44	advmod	_	_
44	evasion	evasion	NN	NN	_	38	conj	_	_
45	of	of	IN	IN	_	47	case	_	_
46	immune	immune	JJ	JJ	_	47	amod	_	_
47	responses	response	NNS	NNS	_	44	nmod	_	_
48	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	4	nsubj	_	_
3	will	will	MD	MD	_	4	aux	_	_
4	cover	cover	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
8	that	that	WDT	WDT	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	utilized	utilize	VBN	VBN	_	7	acl:relcl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	mammalian	mammalian	JJ	JJ	_	14	amod	_	_
13	oncogenic	oncogenic	JJ	JJ	_	14	amod	_	_
14	viruses	virus	NNS	NNS	_	10	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	affect	affect	VB	VB	_	10	xcomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	21	dep	_	_
24	and	and	CC	CC	_	7	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	role	role	NN	NN	_	7	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	regulation	regulation	NN	NN	_	26	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	viral	viral	JJ	JJ	_	35	amod	_	_
35	gene	gene	NN	NN	_	32	nmod	_	_
36	expression	expression	NN	NN	_	35	dep	_	_
37	and	and	CC	CC	_	35	cc	_	_
38	replication	replication	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	4	punct	_	_

1	Mutations	mutation	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TSC2	tsc2	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	:	:	:	:	_	1	punct	_	_
7	analysis	analysis	NN	NN	_	1	dep	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	complete	complete	JJ	JJ	_	12	amod	_	_
11	coding	code	VBG	VBG	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	7	nmod	_	_
13	using	use	VBG	VBG	_	7	acl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	truncation	truncation	NN	NN	_	17	compound	_	_
17	test	test	NN	NN	_	13	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PTT	ptt	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	1	punct	_	_

1	Mutations	mutation	NNS	NNS	_	10	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TSC2	tsc2	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	chromosome	chromosome	NN	NN	_	8	compound	_	_
8	16p13.3	16p13.3	NN	NN	_	5	nmod	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	responsible	responsible	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	approximately	approximately	RB	RB	_	13	advmod	_	_
13	50	50	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	familial	familial	JJ	JJ	_	18	amod	_	_
17	tuberous	tuberous	JJ	JJ	_	18	amod	_	_
18	sclerosis	sclerosis	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TSC	tsc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	41	41	CD	CD	_	6	nummod	_	_
5	small	small	JJ	JJ	_	6	amod	_	_
6	exons	exon	NNS	NNS	_	3	dobj	_	_
7	spanning	span	VBG	VBG	_	6	dep	_	_
8	45	45	CD	CD	_	9	nummod	_	_
9	kb	kb	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	9	case	_	_
11	genomic	genomic	JJ	JJ	_	12	amod	_	_
12	DNA	dna	NN	NN	_	9	dep	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	encoding	encode	VBG	VBG	_	7	conj	_	_
15	a	a	DT	DT	_	18	det	_	_
16	5.5	5.5	CD	CD	_	18	nummod	_	_
17	kb	kb	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	3	punct	_	_

1	Large	large	JJ	JJ	_	3	amod	_	_
2	germline	germline	NN	NN	_	3	compound	_	_
3	deletions	deletion	NNS	NNS	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	TSC2	tsc2	NN	NN	_	3	nmod	_	_
6	occur	occur	VBP	VBP	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	&lt;	&lt;	JJR	JJR	_	9	advmod	_	_
9	5	5	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	cases	case	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	a	a	DT	DT	_	16	det	_	_
16	number	number	NN	NN	_	23	nsubjpass	_	_
17	of	of	IN	IN	_	20	case	_	_
18	small	small	JJ	JJ	_	20	amod	_	_
19	intragenic	intragenic	JJ	JJ	_	20	amod	_	_
20	mutations	mutation	NNS	NNS	_	16	nmod	_	_
21	have	have	VBP	VBP	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	described	describe	VBN	VBN	_	6	conj	_	_
24	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analysed	analyse	VBD	VBD	_	0	root	_	_
3	mRNA	mrna	NN	NN	_	2	dobj	_	_
4	from	from	IN	IN	_	7	case	_	_
5	18	18	CD	CD	_	7	nummod	_	_
6	unrelated	unrelated	JJ	JJ	_	7	amod	_	_
7	cases	case	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TSC	tsc	NN	NN	_	7	nmod	_	_
10	for	for	IN	IN	_	12	case	_	_
11	TSC2	tsc2	NN	NN	_	12	compound	_	_
12	mutations	mutation	NNS	NNS	_	2	nmod	_	_
13	using	use	VBG	VBG	_	2	xcomp	_	_
14	the	the	DT	DT	_	17	det	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	truncation	truncation	NN	NN	_	17	compound	_	_
17	test	test	NN	NN	_	13	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PTT	ptt	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	2	punct	_	_

1	Three	three	CD	CD	_	2	nummod	_	_
2	cases	case	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	predicted	predict	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	TSC2	tsc2	NN	NN	_	8	compound	_	_
8	mutations	mutation	NNS	NNS	_	4	xcomp	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	basis	basis	NN	NN	_	8	dep	_	_
12	of	of	IN	IN	_	14	case	_	_
13	linkage	linkage	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	11	nmod	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	because	because	IN	IN	_	22	mark	_	_
17	a	a	DT	DT	_	18	det	_	_
18	hamartoma	hamartoma	NN	NN	_	22	nsubj	_	_
19	from	from	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	patient	patient	NN	NN	_	18	nmod	_	_
22	showed	show	VBD	VBD	_	11	conj	_	_
23	loss	loss	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	heterozygosity	heterozygosity	NN	NN	_	23	nmod	_	_
26	for	for	IN	IN	_	28	case	_	_
27	16p13.3	16p13.3	NN	NN	_	28	compound	_	_
28	markers	marker	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Three	three	CD	CD	_	4	nummod	_	_
2	overlapping	overlap	VBG	VBG	_	4	amod	_	_
3	PCR	pcr	NN	NN	_	4	compound	_	_
4	products	product	NNS	NNS	_	15	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	covering	cover	VBG	VBG	_	4	acl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	complete	complete	JJ	JJ	_	10	amod	_	_
9	coding	code	VBG	VBG	_	10	amod	_	_
10	sequence	sequence	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	mRNA	mrna	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	generated	generate	VBN	VBN	_	0	root	_	_
16	from	from	IN	IN	_	19	case	_	_
17	lymphoblastoid	lymphoblastoid	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	translated	translate	VBN	VBN	_	15	conj	_	_
22	into	into	IN	IN	_	25	case	_	_
23	35S-methionine	35s-methionine	NN	NN	_	25	compound	_	_
24	labelled	labelled	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	15	punct	_	_
27	and	and	CC	CC	_	15	cc	_	_
28	analysed	analyse	VBN	VBN	_	15	conj	_	_
29	by	by	IN	IN	_	30	case	_	_
30	SDS-PAGE	sds-page	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	PCR	pcr	NN	NN	_	2	compound	_	_
2	products	product	NNS	NNS	_	8	nsubjpass	_	_
3	showing	show	VBG	VBG	_	2	acl	_	_
4	PTT	ptt	NN	NN	_	5	compound	_	_
5	shifts	shift	NNS	NNS	_	3	dobj	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	directly	directly	RB	RB	_	8	advmod	_	_
8	sequenced	sequence	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	mutations	mutation	NNS	NNS	_	12	nsubj	_	_
12	confirmed	confirm	VBN	VBN	_	8	conj	_	_
13	by	by	IN	IN	_	16	case	_	_
14	restriction	restriction	NN	NN	_	16	compound	_	_
15	enzyme	enzyme	NN	NN	_	16	compound	_	_
16	digestion	digestion	NN	NN	_	12	nmod	_	_
17	where	where	WRB	WRB	_	18	advmod	_	_
18	possible	possible	JJ	JJ	_	12	advcl	_	_
19	.	.	.	.	_	8	punct	_	_

1	Six	six	CD	CD	_	3	nummod	_	_
2	PTT	ptt	NN	NN	_	3	compound	_	_
3	shifts	shift	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	.	.	.	.	_	5	punct	_	_

1	Five	five	CD	CD	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	caused	cause	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	mutations	mutation	NNS	NNS	_	5	nmod	_	_
8	predicted	predict	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	produce	produce	VB	VB	_	8	xcomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	truncated	truncate	VBN	VBN	_	13	amod	_	_
13	protein	protein	NN	NN	_	10	dobj	_	_
14	:	:	:	:	_	5	punct	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	i	i	LS	LS	_	21	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	sporadic	sporadic	JJ	JJ	_	20	amod	_	_
20	case	case	NN	NN	_	21	nsubj	_	_
21	showed	show	VBD	VBD	_	5	parataxis	_	_
22	a	a	DT	DT	_	25	det	_	_
23	32	32	CD	CD	_	25	nummod	_	_
24	bp	bp	NN	NN	_	25	compound	_	_
25	deletion	deletion	NN	NN	_	21	dobj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	exon	exon	NN	NN	_	25	nmod	_	_
28	11	11	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	21	punct	_	_
30	and	and	CC	CC	_	21	cc	_	_
31	a	a	DT	DT	_	33	det	_	_
32	mutant	mutant	JJ	JJ	_	33	amod	_	_
33	mRNA	mrna	NN	NN	_	38	nsubjpass	_	_
34	without	without	IN	IN	_	35	case	_	_
35	exon	exon	NN	NN	_	33	nmod	_	_
36	11	11	CD	CD	_	35	nummod	_	_
37	was	be	VBD	VBD	_	38	auxpass	_	_
38	produced	produce	VBN	VBN	_	21	conj	_	_
39	;	;	:	:	_	21	punct	_	_
40	the	the	DT	DT	_	42	det	_	_
41	normal	normal	JJ	JJ	_	42	amod	_	_
42	exon	exon	NN	NN	_	46	nsubjpass	_	_
43	10	10	CD	CD	_	42	nummod	_	_
44	was	be	VBD	VBD	_	46	auxpass	_	_
45	also	also	RB	RB	_	46	advmod	_	_
46	spliced	splice	VBN	VBN	_	21	parataxis	_	_
47	out	out	RP	RP	_	46	compound:prt	_	_
48	;	;	:	:	_	21	punct	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	ii	ii	LS	LS	_	55	dep	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	a	a	DT	DT	_	54	det	_	_
53	sporadic	sporadic	JJ	JJ	_	54	amod	_	_
54	case	case	NN	NN	_	55	nsubj	_	_
55	had	have	VBD	VBD	_	21	parataxis	_	_
56	a	a	DT	DT	_	59	det	_	_
57	1	1	CD	CD	_	59	nummod	_	_
58	bp	bp	NN	NN	_	59	compound	_	_
59	deletion	deletion	NN	NN	_	55	dobj	_	_
60	in	in	IN	IN	_	61	case	_	_
61	exon	exon	NN	NN	_	59	nmod	_	_
62	12	12	CD	CD	_	61	nummod	_	_
63	(	(	-LRB-	-LRB-	_	64	punct	_	_
64	1634delT	1634delt	NN	NN	_	59	appos	_	_
65	)	)	-RRB-	-RRB-	_	64	punct	_	_
66	;	;	:	:	_	21	punct	_	_
67	(	(	-LRB-	-LRB-	_	68	punct	_	_
68	iii	iii	LS	LS	_	76	dep	_	_
69	)	)	-RRB-	-RRB-	_	68	punct	_	_
70	a	a	DT	DT	_	72	det	_	_
71	TSC2-linked	tsc2-linked	JJ	JJ	_	72	amod	_	_
72	mother	mother	NN	NN	_	76	nsubj	_	_
73	and	and	CC	CC	_	72	cc	_	_
74	daughter	daughter	NN	NN	_	75	compound	_	_
75	pair	pair	NN	NN	_	72	conj	_	_
76	had	have	VBD	VBD	_	21	parataxis	_	_
77	a	a	DT	DT	_	81	det	_	_
78	G	g	NN	NN	_	81	compound	_	_
79	--&gt;	--&gt;	TO	TO	_	81	dep	_	_
80	T	t	NN	NN	_	81	compound	_	_
81	transversion	transversion	NN	NN	_	76	dobj	_	_
82	in	in	IN	IN	_	83	case	_	_
83	exon	exon	NN	NN	_	81	nmod	_	_
84	23	23	CD	CD	_	83	nummod	_	_
85	(	(	-LRB-	-LRB-	_	86	punct	_	_
86	G2715T	g2715t	NN	NN	_	81	appos	_	_
87	)	)	-RRB-	-RRB-	_	86	punct	_	_
88	introducing	introduce	VBG	VBG	_	81	acl	_	_
89	a	a	DT	DT	_	92	det	_	_
90	cryptic	cryptic	JJ	JJ	_	92	amod	_	_
91	splice	splice	NN	NN	_	92	compound	_	_
92	site	site	NN	NN	_	88	dobj	_	_
93	causing	cause	VBG	VBG	_	92	acl	_	_
94	a	a	DT	DT	_	97	det	_	_
95	29	29	CD	CD	_	97	nummod	_	_
96	bp	bp	NN	NN	_	97	compound	_	_
97	truncation	truncation	NN	NN	_	93	dobj	_	_
98	of	of	IN	IN	_	99	case	_	_
99	mRNA	mrna	NN	NN	_	97	nmod	_	_
100	from	from	IN	IN	_	101	case	_	_
101	exon	exon	NN	NN	_	97	nmod	_	_
102	23	23	CD	CD	_	101	nummod	_	_
103	;	;	:	:	_	21	punct	_	_
104	(	(	-LRB-	-LRB-	_	105	punct	_	_
105	iv	iv	LS	LS	_	110	dep	_	_
106	)	)	-RRB-	-RRB-	_	105	punct	_	_
107	a	a	DT	DT	_	109	det	_	_
108	sporadic	sporadic	JJ	JJ	_	109	amod	_	_
109	case	case	NN	NN	_	110	nsubj	_	_
110	showed	show	VBD	VBD	_	21	parataxis	_	_
111	a	a	DT	DT	_	114	det	_	_
112	2	2	CD	CD	_	114	nummod	_	_
113	bp	bp	NN	NN	_	114	compound	_	_
114	deletion	deletion	NN	NN	_	110	dobj	_	_
115	in	in	IN	IN	_	116	case	_	_
116	exon	exon	NN	NN	_	114	nmod	_	_
117	36	36	CD	CD	_	116	nummod	_	_
118	;	;	:	:	_	21	punct	_	_
119	(	(	-LRB-	-LRB-	_	120	punct	_	_
120	v	v	LS	LS	_	125	dep	_	_
121	)	)	-RRB-	-RRB-	_	120	punct	_	_
122	a	a	DT	DT	_	124	det	_	_
123	sporadic	sporadic	JJ	JJ	_	124	amod	_	_
124	case	case	NN	NN	_	125	nsubj	_	_
125	showed	show	VBD	VBD	_	21	parataxis	_	_
126	a	a	DT	DT	_	129	det	_	_
127	1	1	CD	CD	_	129	nummod	_	_
128	bp	bp	NN	NN	_	129	compound	_	_
129	insertion	insertion	NN	NN	_	125	dobj	_	_
130	disrupting	disrupt	VBG	VBG	_	129	acl	_	_
131	the	the	DT	DT	_	134	det	_	_
132	donor	donor	NN	NN	_	134	compound	_	_
133	splice	splice	NN	NN	_	134	compound	_	_
134	site	site	NN	NN	_	130	dobj	_	_
135	of	of	IN	IN	_	136	case	_	_
136	exon	exon	NN	NN	_	134	nmod	_	_
137	37	37	CD	CD	_	136	nummod	_	_
138	(	(	-LRB-	-LRB-	_	139	punct	_	_
139	5007+2insA	5007+2insa	NN	NN	_	129	appos	_	_
140	)	)	-RRB-	-RRB-	_	139	punct	_	_
141	,	,	,	,	_	125	punct	_	_
142	resulting	result	VBG	VBG	_	125	advcl	_	_
143	in	in	IN	IN	_	145	case	_	_
144	the	the	DT	DT	_	145	det	_	_
145	use	use	NN	NN	_	142	nmod	_	_
146	of	of	IN	IN	_	152	case	_	_
147	an	a	DT	DT	_	152	det	_	_
148	upstream	upstream	JJ	JJ	_	152	amod	_	_
149	exonic	exonic	JJ	JJ	_	152	amod	_	_
150	cryptic	cryptic	JJ	JJ	_	152	amod	_	_
151	splice	splice	NN	NN	_	152	compound	_	_
152	site	site	NN	NN	_	145	nmod	_	_
153	to	to	TO	TO	_	154	mark	_	_
154	cause	cause	VB	VB	_	142	xcomp	_	_
155	a	a	DT	DT	_	158	det	_	_
156	29	29	CD	CD	_	158	nummod	_	_
157	bp	bp	NN	NN	_	158	compound	_	_
158	truncation	truncation	NN	NN	_	154	dobj	_	_
159	of	of	IN	IN	_	160	case	_	_
160	mRNA	mrna	NN	NN	_	158	nmod	_	_
161	from	from	IN	IN	_	162	case	_	_
162	exon	exon	NN	NN	_	158	nmod	_	_
163	37	37	CD	CD	_	162	nummod	_	_
164	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	one	one	CD	CD	_	3	nummod	_	_
3	case	case	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	PTT	ptt	NN	NN	_	7	compound	_	_
7	shift	shift	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	explained	explain	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	in-frame	in-frame	JJ	JJ	_	12	amod	_	_
12	splicing	splicing	NN	NN	_	9	nmod	_	_
13	out	out	RP	RP	_	15	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	exon	exon	NN	NN	_	12	nmod	_	_
16	10	10	CD	CD	_	15	nummod	_	_
17	,	,	,	,	_	12	punct	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	presence	presence	NN	NN	_	12	nmod	_	_
21	of	of	IN	IN	_	27	case	_	_
22	a	a	DT	DT	_	27	det	_	_
23	normal	normal	JJ	JJ	_	27	amod	_	_
24	exon	exon	NN	NN	_	27	compound	_	_
25	10	10	CD	CD	_	27	nummod	_	_
26	genomic	genomic	JJ	JJ	_	27	amod	_	_
27	sequence	sequence	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Alternative	alternative	JJ	JJ	_	2	amod	_	_
2	splicing	splicing	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	exon	exon	NN	NN	_	2	nmod	_	_
5	10	10	CD	CD	_	4	nummod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	TSC2	tsc2	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	2	nmod	_	_
10	may	may	MD	MD	_	14	aux	_	_
11	be	be	VB	VB	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	normal	normal	JJ	JJ	_	14	amod	_	_
14	variant	variant	NN	NN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Three	three	CD	CD	_	5	nummod	_	_
2	3rd	3rd	JJ	JJ	_	5	amod	_	_
3	base	base	NN	NN	_	5	compound	_	_
4	substitution	substitution	NN	NN	_	5	compound	_	_
5	polymorphisms	polymorphism	NNS	NNS	_	8	nsubjpass	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	during	during	IN	IN	_	11	case	_	_
10	direct	direct	JJ	JJ	_	11	amod	_	_
11	sequencing	sequencing	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	PCR	pcr	NN	NN	_	14	compound	_	_
14	products	product	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Confirmed	confirm	VBN	VBN	_	2	amod	_	_
2	mutations	mutation	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	28	28	CD	CD	_	7	nummod	_	_
7	%	%	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	families	family	NNS	NNS	_	7	nmod	_	_
11	studied	study	VBN	VBN	_	10	acl	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	assumption	assumption	NN	NN	_	37	nmod	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	half	half	NN	NN	_	23	nsubj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	sporadic	sporadic	JJ	JJ	_	21	amod	_	_
21	cases	case	NNS	NNS	_	17	nmod	_	_
22	should	should	MD	MD	_	23	aux	_	_
23	have	have	VB	VB	_	15	ccomp	_	_
24	TSC2	tsc2	NN	NN	_	25	compound	_	_
25	mutations	mutation	NNS	NNS	_	23	dobj	_	_
26	,	,	,	,	_	37	punct	_	_
27	a	a	DT	DT	_	29	det	_	_
28	crude	crude	JJ	JJ	_	29	amod	_	_
29	estimate	estimate	NN	NN	_	37	nsubj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	detection	detection	NN	NN	_	33	compound	_	_
33	rate	rate	NN	NN	_	29	nmod	_	_
34	would	would	MD	MD	_	37	aux	_	_
35	be	be	VB	VB	_	37	cop	_	_
36	60	60	CD	CD	_	37	nummod	_	_
37	%	%	NN	NN	_	4	conj	_	_
38	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	compares	compare	VBZ	VBZ	_	0	root	_	_
3	favourably	favourably	RB	RB	_	2	advmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	other	other	JJ	JJ	_	7	amod	_	_
6	screening	screening	NN	NN	_	7	compound	_	_
7	methods	method	NNS	NNS	_	2	nmod	_	_
8	used	use	VBN	VBN	_	7	acl	_	_
9	for	for	IN	IN	_	10	case	_	_
10	TSC2	tsc2	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	notably	notably	RB	RB	_	13	advmod	_	_
13	SSCP	sscp	NN	NN	_	10	appos	_	_
14	,	,	,	,	_	2	punct	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	since	since	IN	IN	_	18	mark	_	_
17	PTT	ptt	NN	NN	_	18	nsubj	_	_
18	involves	involve	VBZ	VBZ	_	26	advcl	_	_
19	much	much	RB	RB	_	20	advmod	_	_
20	less	less	JJR	JJR	_	21	amod	_	_
21	work	work	NN	NN	_	18	dobj	_	_
22	it	it	PRP	PRP	_	26	nsubj	_	_
23	may	may	MD	MD	_	26	aux	_	_
24	be	be	VB	VB	_	26	cop	_	_
25	the	the	DT	DT	_	26	det	_	_
26	method	method	NN	NN	_	2	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	choice	choice	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Selection	selection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	down-regulated	down-regulate	VBN	VBN	_	4	amod	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	along	along	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	leukemic	leukemic	JJ	JJ	_	12	amod	_	_
11	HL60	hl60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	dissect	dissect	VB	VB	_	13	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	nmod	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	developed	develop	VBN	VBN	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	subtractive	subtractive	JJ	JJ	_	17	amod	_	_
16	hybridisation	hybridisation	NN	NN	_	17	compound	_	_
17	method	method	NN	NN	_	13	dobj	_	_
18	based	base	VBN	VBN	_	25	case	_	_
19	on	on	IN	IN	_	25	case	_	_
20	a	a	DT	DT	_	25	det	_	_
21	simplified	simplified	JJ	JJ	_	25	amod	_	_
22	'	'	``	``	_	25	punct	_	_
23	representational	representational	JJ	JJ	_	25	amod	_	_
24	difference	difference	NN	NN	_	25	compound	_	_
25	analysis	analysis	NN	NN	_	13	advcl	_	_
26	'	'	''	''	_	25	punct	_	_
27	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	selected	select	VBN	VBN	_	0	root	_	_
4	16	16	CD	CD	_	5	nummod	_	_
5	sequences	sequence	NNS	NNS	_	3	dobj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	confirmed	confirm	VBN	VBN	_	3	conj	_	_
8	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
9	down-regulation	down-regulation	NN	NN	_	7	dobj	_	_
10	along	along	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	TPA-induced	tpa-induced	JJ	JJ	_	14	amod	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HL60	hl60	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Among	among	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	sequences	sequence	NNS	NNS	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	alpha-tubulin	alpha-tubulin	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	TaxREB	taxreb	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	appos	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	two	two	CD	CD	_	17	nummod	_	_
15	ribosomal	ribosomal	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	sequences	sequence	NNS	NNS	_	8	conj	_	_
18	which	which	WDT	WDT	_	23	nsubjpass	_	_
19	had	have	VBD	VBD	_	23	aux	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	been	be	VBN	VBN	_	23	auxpass	_	_
22	previously	previously	RB	RB	_	23	advmod	_	_
23	described	describe	VBN	VBN	_	17	acl:relcl	_	_
24	as	as	IN	IN	_	26	mark	_	_
25	differentially	differentially	RB	RB	_	26	advmod	_	_
26	expressed	express	VBN	VBN	_	23	advcl	_	_
27	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	add	add	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	knowledge	knowledge	NN	NN	_	3	nmod	_	_
7	about	about	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	molecules	molecule	NNS	NNS	_	6	nmod	_	_
10	implicated	implicate	VBN	VBN	_	9	acl	_	_
11	along	along	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	growth	growth	NN	NN	_	17	compound	_	_
17	arrest	arrest	NN	NN	_	14	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	leukemic	leukemic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	and	and	CC	CC	_	3	cc	_	_
22	provide	provide	VBP	VBP	_	3	conj	_	_
23	a	a	DT	DT	_	25	det	_	_
24	first	first	JJ	JJ	_	25	amod	_	_
25	step	step	NN	NN	_	22	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	study	study	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	their	they	PRP$	PRP$	_	32	nmod:poss	_	_
31	respective	respective	JJ	JJ	_	32	amod	_	_
32	roles	role	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	novel	novel	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	3q21	3q21	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	1	cc	_	_
9	identification	identification	NN	NN	_	1	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	intergenic	intergenic	JJ	JJ	_	13	amod	_	_
12	fusion	fusion	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	9	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	ecotropic	ecotropic	JJ	JJ	_	18	amod	_	_
16	viral	viral	JJ	JJ	_	18	amod	_	_
17	insertion	insertion	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	13	nmod	_	_
19	I	i	CD	CD	_	18	nummod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	leukemia	leukemia	NN	NN	_	1	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	gene	gene	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	GR6	gr6	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	located	located	JJ	JJ	_	6	amod	_	_
11	within	within	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	leukemia	leukemia	NN	NN	_	15	compound	_	_
14	breakpoint	breakpoint	NN	NN	_	15	compound	_	_
15	region	region	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	3q21	3q21	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	that	that	WDT	WDT	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	normally	normally	RB	RB	_	22	advmod	_	_
22	expressed	express	VBN	VBN	_	6	acl:relcl	_	_
23	in	in	IN	IN	_	26	case	_	_
24	early	early	JJ	JJ	_	26	amod	_	_
25	fetal	fetal	JJ	JJ	_	26	amod	_	_
26	development	development	NN	NN	_	22	nmod	_	_
27	but	but	CC	CC	_	26	cc	_	_
28	not	not	RB	RB	_	32	neg	_	_
29	in	in	IN	IN	_	32	case	_	_
30	adult	adult	JJ	JJ	_	32	amod	_	_
31	peripheral	peripheral	JJ	JJ	_	32	amod	_	_
32	blood	blood	NN	NN	_	26	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	GR6	gr6	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	activated	activate	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	UCSD-AML1	ucsd-aml1	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	in	in	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	leukemic	leukemic	JJ	JJ	_	13	amod	_	_
13	sample	sample	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	3	punct	_	_
15	both	both	DT	DT	_	18	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	15	nmod	_	_
18	carry	carry	VBP	VBP	_	3	ccomp	_	_
19	a	a	DT	DT	_	20	det	_	_
20	t(3;3)(q21;q26)	t(3;3)(q21;q26)	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	UCSD-AML1	ucsd-aml1	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	we	we	PRP	PRP	_	7	nsubj	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	fusion	fusion	NN	NN	_	9	compound	_	_
9	transcripts	transcript	NNS	NNS	_	7	dobj	_	_
10	between	between	IN	IN	_	20	case	_	_
11	the	the	DT	DT	_	20	det	_	_
12	ecotropic	ecotropic	JJ	JJ	_	20	amod	_	_
13	viral	viral	JJ	JJ	_	20	amod	_	_
14	insertion	insertion	NN	NN	_	20	compound	_	_
15	site	site	NN	NN	_	20	compound	_	_
16	I	i	CD	CD	_	20	nummod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	EVI1	evi1	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	gene	gene	NN	NN	_	7	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	3q26	3q26	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	GR6	gr6	NN	NN	_	20	conj	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	between	between	IN	IN	_	27	case	_	_
27	EVI1	evi1	NN	NN	_	20	conj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	Ribophorin	ribophorin	NN	NN	_	30	compound	_	_
30	I	i	NN	NN	_	27	conj	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	maps	map	VBZ	VBZ	_	30	acl:relcl	_	_
33	30	30	CD	CD	_	35	nummod	_	_
34	kb	kb	NN	NN	_	35	compound	_	_
35	telomeric	telomeric	NN	NN	_	32	dobj	_	_
36	to	to	TO	TO	_	37	case	_	_
37	GR6	gr6	NN	NN	_	32	nmod	_	_
38	in	in	IN	IN	_	39	case	_	_
39	3q21	3q21	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	7	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	fusions	fusion	NNS	NNS	_	3	nsubj	_	_
3	splice	splice	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	5'	5'	JJ	JJ	_	6	amod	_	_
6	ends	end	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	3q21	3q21	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	into	into	IN	IN	_	12	case	_	_
12	exon	exon	NN	NN	_	3	nmod	_	_
13	2	2	CD	CD	_	12	nummod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	EVI1	evi1	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	an	a	DT	DT	_	20	det	_	_
20	event	event	NN	NN	_	3	dep	_	_
21	that	that	WDT	WDT	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	similar	similar	JJ	JJ	_	20	acl:relcl	_	_
24	to	to	TO	TO	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	normal	normal	JJ	JJ	_	28	amod	_	_
27	intergenic	intergenic	JJ	JJ	_	28	amod	_	_
28	splicing	splicing	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	MDS1-EVI1	mds1-evi1	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	to	to	TO	TO	_	33	case	_	_
33	those	those	DT	DT	_	28	conj	_	_
34	previously	previously	RB	RB	_	35	advmod	_	_
35	documented	document	VBN	VBN	_	33	acl	_	_
36	in	in	IN	IN	_	37	case	_	_
37	leukemias	leukemia	NNS	NNS	_	35	nmod	_	_
38	with	with	IN	IN	_	39	case	_	_
39	t(3;21)	t(3;21)	NN	NN	_	37	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	t(3;12)	t(3;12)	NN	NN	_	39	conj	_	_
42	,	,	,	,	_	20	punct	_	_
43	in	in	IN	IN	_	44	case	_	_
44	which	which	WDT	WDT	_	56	nmod	_	_
45	acute	acute	JJ	JJ	_	49	amod	_	_
46	myelogenous	myelogenous	JJ	JJ	_	49	amod	_	_
47	leukemia	leukemia	NN	NN	_	49	compound	_	_
48	1-EVI1	1-evi1	NN	NN	_	49	compound	_	_
49	fusions	fusion	NNS	NNS	_	56	nsubj	_	_
50	and	and	CC	CC	_	49	cc	_	_
51	ETV6-EVI1	etv6-evi1	JJ	JJ	_	52	amod	_	_
52	fusions	fusion	NNS	NNS	_	49	conj	_	_
53	,	,	,	,	_	49	punct	_	_
54	respectively	respectively	RB	RB	_	56	advmod	_	_
55	,	,	,	,	_	56	punct	_	_
56	occur	occur	VBP	VBP	_	20	acl:relcl	_	_
57	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Ribophorin	ribophorin	NN	NN	_	4	compound	_	_
3	I-EVI1	i-evi1	NN	NN	_	4	compound	_	_
4	fusion	fusion	NN	NN	_	11	nsubj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	particular	particular	JJ	JJ	_	11	nmod	_	_
7	may	may	MD	MD	_	11	aux	_	_
8	be	be	VB	VB	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	common	common	JJ	JJ	_	11	amod	_	_
11	occurrence	occurrence	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	t(3;3)	t(3;3)	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	11	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	cycle	cycle	NN	NN	_	6	compound	_	_
6	progression	progression	NN	NN	_	2	conj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	humans	human	NNS	NNS	_	2	nmod	_	_
9	exposed	expose	VBN	VBN	_	8	acl	_	_
10	to	to	TO	TO	_	17	case	_	_
11	methyl	methyl	NN	NN	_	13	compound	_	_
12	tertiary-butyl	tertiary-butyl	NN	NN	_	13	compound	_	_
13	ether	ether	NN	NN	_	16	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	benzene	benzene	NN	NN	_	13	conj	_	_
16	contaminating	contaminating	NN	NN	_	17	amod	_	_
17	water	water	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	1	1	CD	CD	_	7	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	In	in	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	7	nmod	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	22	mark	_	_
9	in	in	IN	IN	_	10	case	_	_
10	individuals	individual	NNS	NNS	_	22	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	certain	certain	JJ	JJ	_	14	amod	_	_
13	genetic	genetic	JJ	JJ	_	14	amod	_	_
14	makeup	makeup	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	22	punct	_	_
16	MTBE	mtbe	NN	NN	_	22	nsubj	_	_
17	,	,	,	,	_	16	punct	_	_
18	benzene	benzene	NN	NN	_	16	conj	_	_
19	or	or	CC	CC	_	16	cc	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	metabolites	metabolite	NNS	NNS	_	16	conj	_	_
22	act	act	VBP	VBP	_	7	ccomp	_	_
23	as	as	IN	IN	_	24	case	_	_
24	adducts	adduct	NNS	NNS	_	22	nmod	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	induce	induce	VB	VB	_	22	conj	_	_
28	programmed	program	VBN	VBN	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	death	death	NN	NN	_	27	dobj	_	_
31	.	.	.	.	_	7	punct	_	_

1	2	2	CD	CD	_	5	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	study	study	NN	NN	_	5	nsubj	_	_
5	involved	involve	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	group	group	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	60	60	CD	CD	_	13	nummod	_	_
10	male	male	NN	NN	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	female	female	JJ	JJ	_	10	conj	_	_
13	subjects	subject	NNS	NNS	_	7	nmod	_	_
14	who	who	WP	WP	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	exposed	expose	VBN	VBN	_	7	acl:relcl	_	_
17	to	to	TO	TO	_	21	case	_	_
18	MTBE	mtbe	NN	NN	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	benzene-contaminated	benzene-contaminated	JJ	JJ	_	18	conj	_	_
21	water	water	NN	NN	_	16	nmod	_	_
22	concentrations	concentration	NNS	NNS	_	21	dep	_	_
23	up	up	IN	IN	_	25	dep	_	_
24	to	to	TO	TO	_	23	mwe	_	_
25	76	76	CD	CD	_	26	nummod	_	_
26	PPB	ppb	NN	NN	_	22	dep	_	_
27	for	for	IN	IN	_	28	case	_	_
28	MTBE	mtbe	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	14	14	CD	CD	_	31	nummod	_	_
31	PPB	ppb	NN	NN	_	26	conj	_	_
32	for	for	IN	IN	_	33	case	_	_
33	benzene	benzene	NN	NN	_	31	nmod	_	_
34	,	,	,	,	_	16	punct	_	_
35	for	for	IN	IN	_	37	case	_	_
36	a	a	DT	DT	_	37	det	_	_
37	period	period	NN	NN	_	16	nmod	_	_
38	of	of	IN	IN	_	42	case	_	_
39	5	5	CD	CD	_	41	compound	_	_
40	to	to	TO	TO	_	41	dep	_	_
41	8	8	CD	CD	_	42	nummod	_	_
42	years	year	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	5	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	recruited	recruit	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	control	control	NN	NN	_	8	compound	_	_
8	group	group	NN	NN	_	5	dobj	_	_
9	consisting	consist	VBG	VBG	_	8	acl	_	_
10	of	of	IN	IN	_	13	case	_	_
11	32	32	CD	CD	_	13	nummod	_	_
12	healthy	healthy	JJ	JJ	_	13	amod	_	_
13	males	male	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	females	female	NNS	NNS	_	13	conj	_	_
16	with	with	IN	IN	_	19	case	_	_
17	similar	similar	JJ	JJ	_	19	amod	_	_
18	age	age	NN	NN	_	19	compound	_	_
19	distribution	distribution	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	without	without	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	history	history	NN	NN	_	19	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	exposure	exposure	NN	NN	_	23	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	MTBE	mtbe	NN	NN	_	25	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	benzene	benzene	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	5	punct	_	_

1	3	3	CD	CD	_	13	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Peripheral	peripheral	JJ	JJ	_	5	amod	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	13	nsubjpass	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PBL	pbl	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	dep	_	_
11	groups	group	NNS	NNS	_	5	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	tested	test	VBN	VBN	_	0	root	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	percentage	percentage	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	apoptotic	apoptotic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	cycle	cycle	NN	NN	_	23	compound	_	_
23	progression	progression	NN	NN	_	16	conj	_	_
24	using	use	VBG	VBG	_	13	xcomp	_	_
25	flow	flow	NN	NN	_	26	compound	_	_
26	cytometry	cytometry	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	13	punct	_	_

1	4	4	LS	LS	_	26	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	When	when	WRB	WRB	_	10	advmod	_	_
4	apoptotic	apoptotic	JJ	JJ	_	5	amod	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	10	nsubjpass	_	_
6	from	from	IN	IN	_	8	case	_	_
7	exposed	expose	VBN	VBN	_	8	amod	_	_
8	individuals	individual	NNS	NNS	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	compared	compare	VBN	VBN	_	26	advcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	apoptotic	apoptotic	JJ	JJ	_	13	amod	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	from	from	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	control	control	JJ	JJ	_	17	amod	_	_
17	group	group	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	26	punct	_	_
19	statistically-significant	statistically-significant	JJ	JJ	_	20	amod	_	_
20	differences	difference	NNS	NNS	_	26	nsubjpass	_	_
21	between	between	IN	IN	_	24	case	_	_
22	each	each	DT	DT	_	24	det	_	_
23	mean	mean	NN	NN	_	24	compound	_	_
24	group	group	NN	NN	_	20	nmod	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	detected	detect	VBN	VBN	_	0	root	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	26.4	26.4	CD	CD	_	26	dep	_	_
29	+/-	+/-	CC	CC	_	28	cc	_	_
30	1.8	1.8	CD	CD	_	28	conj	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	12.1	12.1	CD	CD	_	28	conj	_	_
33	+/-	+/-	CC	CC	_	32	cc	_	_
34	1.3	1.3	CD	CD	_	32	conj	_	_
35	,	,	,	,	_	28	punct	_	_
36	respectively	respectively	RB	RB	_	28	advmod	_	_
37	)	)	-RRB-	-RRB-	_	28	punct	_	_
38	,	,	,	,	_	26	punct	_	_
39	indicating	indicate	VBG	VBG	_	26	dep	_	_
40	an	a	DT	DT	_	42	det	_	_
41	increased	increase	VBN	VBN	_	42	amod	_	_
42	rate	rate	NN	NN	_	39	dobj	_	_
43	of	of	IN	IN	_	44	case	_	_
44	apoptosis	apoptosis	NN	NN	_	42	nmod	_	_
45	in	in	IN	IN	_	47	case	_	_
46	80.5	80.5	CD	CD	_	47	nummod	_	_
47	%	%	NN	NN	_	42	nmod	_	_
48	of	of	IN	IN	_	50	case	_	_
49	exposed	expose	VBN	VBN	_	50	amod	_	_
50	individuals	individual	NNS	NNS	_	47	nmod	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	P	p	NN	NN	_	42	dep	_	_
53	&lt;	&lt;	JJR	JJR	_	52	amod	_	_
54	0.0001	0.0001	CD	CD	_	53	dep	_	_
55	,	,	,	,	_	52	punct	_	_
56	Mann-Whitney	mann-whitney	JJ	JJ	_	57	amod	_	_
57	U-Test	u-test	NN	NN	_	52	appos	_	_
58	)	)	-RRB-	-RRB-	_	52	punct	_	_
59	.	.	.	.	_	26	punct	_	_

1	MTBE	mtbe	NN	NN	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	benzene-induced	benzene-induced	JJ	JJ	_	1	conj	_	_
4	apoptosis	apoptosis	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	attributed	attribute	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	discrete	discrete	JJ	JJ	_	10	amod	_	_
10	block	block	NN	NN	_	6	nmod	_	_
11	within	within	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	cycle	cycle	NN	NN	_	15	compound	_	_
15	progression	progression	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	cycle	cycle	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	in	in	IN	IN	_	8	case	_	_
8	PBL	pbl	NNS	NNS	_	19	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	chemically-exposed	chemically-exposed	JJ	JJ	_	11	amod	_	_
11	individuals	individual	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	19	punct	_	_
13	between	between	IN	IN	_	14	advmod	_	_
14	20-50	20-50	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	19	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	cells	cell	NNS	NNS	_	15	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	accumulated	accumulate	VBN	VBN	_	5	ccomp	_	_
20	at	at	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	S-G2/M	s-g2/m	JJ	JJ	_	23	amod	_	_
23	boundaries	boundary	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	5	5	CD	CD	_	16	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	One	one	CD	CD	_	16	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	signaling	signal	VBG	VBG	_	7	amod	_	_
7	molecules	molecule	NNS	NNS	_	3	nmod	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	mediates	mediate	VBZ	VBZ	_	3	acl:relcl	_	_
10	programmed	program	VBN	VBN	_	9	dep	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	death	death	NN	NN	_	10	dobj	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	factor	factor	NN	NN	_	16	compound	_	_
16	Kappa-B	kappa-b	NN	NN	_	0	root	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	16	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	as	as	IN	IN	_	6	case	_	_
6	one	one	CD	CD	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	many	many	JJ	JJ	_	11	amod	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	6	nmod	_	_
12	for	for	IN	IN	_	13	mark	_	_
13	mediating	mediate	VBG	VBG	_	11	acl	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	death	death	NN	NN	_	13	dobj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	MTBE	mtbe	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	benzene	benzene	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	Indeed	indeed	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	addition	addition	NN	NN	_	24	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	inhibitors	inhibitor	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	pyrrolidine	pyrrolidine	NN	NN	_	11	compound	_	_
11	dithiocarbamate	dithiocarbamate	NN	NN	_	5	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PDTC	pdtc	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	3	punct	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	chemically-exposed	chemically-exposed	JJ	JJ	_	22	amod	_	_
22	group	group	NN	NN	_	18	nmod	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	capable	capable	JJ	JJ	_	0	root	_	_
25	of	of	IN	IN	_	26	mark	_	_
26	inhibiting	inhibit	VBG	VBG	_	24	advcl	_	_
27	programmed	program	VBN	VBN	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	death	death	NN	NN	_	26	dobj	_	_
30	by	by	IN	IN	_	32	case	_	_
31	40	40	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	24	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	reversal	reversal	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	almost	almost	RB	RB	_	9	advmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	control	control	NN	NN	_	9	compound	_	_
9	level	level	NN	NN	_	2	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	inhibitor	inhibitor	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	indicate	indicate	VB	VB	_	0	root	_	_
18	involvement	involvement	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	this	this	DT	DT	_	22	det	_	_
21	signaling	signal	VBG	VBG	_	22	amod	_	_
22	molecule	molecule	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	MTBE	mtbe	NN	NN	_	18	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	benzene	benzene	NN	NN	_	24	conj	_	_
27	induction	induction	NN	NN	_	24	dep	_	_
28	of	of	IN	IN	_	31	case	_	_
29	programmed	program	VBN	VBN	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	death	death	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	17	punct	_	_

1	Alcohol-induced	alcohol-induced	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
6	factor-kappa	factor-kappa	NN	NN	_	7	compound	_	_
7	beta	beta	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	ethanol	ethanol	NN	NN	_	3	compound	_	_
3	exposure	exposure	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	capacity	capacity	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	modulate	modulate	VB	VB	_	6	dep	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	functions	function	NNS	NNS	_	8	dobj	_	_
11	,	,	,	,	_	8	punct	_	_
12	particularly	particularly	RB	RB	_	16	advmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	down	down	RP	RP	_	16	dep	_	_
16	regulate	regulate	VB	VB	_	8	dep	_	_
17	monocyte	monocyte	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	inflammatory	inflammatory	JJ	JJ	_	21	amod	_	_
21	cytokines	cytokine	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	11	nsubj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	effects	effect	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	ethanol	ethanol	NN	NN	_	8	nmod	_	_
11	are	be	VBP	VBP	_	0	root	_	_
12	yet	yet	RB	RB	_	11	advmod	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	understood	understand	VBN	VBN	_	11	xcomp	_	_
16	.	.	.	.	_	11	punct	_	_

1	Considering	consider	VBG	VBG	_	16	case	_	_
2	that	that	IN	IN	_	16	mark	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	16	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	11	punct	_	_
8	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
9	B	b	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	/Rel	/rel	NN	NN	_	6	dep	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	a	a	DT	DT	_	16	det	_	_
14	common	common	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	30	advcl	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	region	region	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	inflammatory	inflammatory	JJ	JJ	_	25	amod	_	_
24	cytokine	cytokine	NN	NN	_	25	compound	_	_
25	genes	gene	NNS	NNS	_	20	nmod	_	_
26	,	,	,	,	_	30	punct	_	_
27	herein	herein	RB	RB	_	30	advmod	_	_
28	,	,	,	,	_	30	punct	_	_
29	we	we	PRP	PRP	_	30	nsubj	_	_
30	tested	test	VBD	VBD	_	0	root	_	_
31	the	the	DT	DT	_	32	det	_	_
32	hypothesis	hypothesis	NN	NN	_	30	dobj	_	_
33	that	that	IN	IN	_	36	mark	_	_
34	acute	acute	JJ	JJ	_	35	amod	_	_
35	ethanol	ethanol	NN	NN	_	36	nsubj	_	_
36	affects	affect	VBZ	VBZ	_	32	ccomp	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	39	compound	_	_
39	activation	activation	NN	NN	_	36	dobj	_	_
40	in	in	IN	IN	_	42	case	_	_
41	human	human	JJ	JJ	_	42	amod	_	_
42	monocytes	monocyte	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	30	punct	_	_

1	Adherence-isolated	adherence-isolated	JJ	JJ	_	2	amod	_	_
2	monocytes	monocyte	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	clinically	clinically	RB	RB	_	3	advmod	_	_
3	relevant	relevant	JJ	JJ	_	4	amod	_	_
4	dose	dose	NN	NN	_	15	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	25	25	CD	CD	_	7	nummod	_	_
7	mM	mm	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	12	case	_	_
10	acute	acute	JJ	JJ	_	12	amod	_	_
11	ethanol	ethanol	NN	NN	_	12	compound	_	_
12	treatment	treatment	NN	NN	_	4	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	4	advmod	_	_
15	increased	increase	VBD	VBD	_	0	root	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	15	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	preferential	preferential	JJ	JJ	_	25	amod	_	_
25	induction	induction	NN	NN	_	15	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	inhibitory	inhibitory	JJ	JJ	_	25	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	p50/p50	p50/p50	NN	NN	_	28	appos	_	_
31	,	,	,	,	_	28	punct	_	_
32	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
33	B/Rel	b/rel	NN	NN	_	34	compound	_	_
34	homodimer	homodimer	NN	NN	_	28	appos	_	_
35	,	,	,	,	_	15	punct	_	_
36	and	and	CC	CC	_	15	cc	_	_
37	resulted	result	VBD	VBD	_	15	conj	_	_
38	in	in	IN	IN	_	40	case	_	_
39	no	no	DT	DT	_	40	neg	_	_
40	induction	induction	NN	NN	_	37	nmod	_	_
41	of	of	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	p65/p50	p65/p50	NN	NN	_	44	compound	_	_
44	heterodimer	heterodimer	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	compound	_	_
5	stimulation	stimulation	NN	NN	_	7	nsubj	_	_
6	primarily	primarily	RB	RB	_	7	advmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	p65/p50	p65/p50	NN	NN	_	10	compound	_	_
10	heterodimer	heterodimer	NN	NN	_	7	dobj	_	_
11	that	that	WDT	WDT	_	14	nsubjpass	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	10	acl:relcl	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	result	result	VB	VB	_	14	xcomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	such	such	JJ	JJ	_	4	amod	_	_
4	unique	unique	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	inhibitory	inhibitory	JJ	JJ	_	10	amod	_	_
9	p50/p50	p50/p50	NN	NN	_	10	compound	_	_
10	homodimer	homodimer	NN	NN	_	5	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	acute	acute	JJ	JJ	_	14	amod	_	_
13	ethanol	ethanol	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	5	nmod	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	result	result	VB	VB	_	0	root	_	_
17	in	in	IN	IN	_	18	case	_	_
18	inhibition	inhibition	NN	NN	_	16	nmod	_	_
19	rather	rather	RB	RB	_	18	cc	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	activation	activation	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	27	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
24	B-regulated	b-regulated	JJ	JJ	_	27	amod	_	_
25	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
26	cytokine	cytokine	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	18	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	Consequently	consequently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	physiologically	physiologically	RB	RB	_	8	advmod	_	_
8	relevant	relevant	JJ	JJ	_	9	amod	_	_
9	concentrations	concentration	NNS	NNS	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	ethanol	ethanol	NN	NN	_	9	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	affect	affect	VB	VB	_	5	ccomp	_	_
14	production	production	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	cytokines	cytokine	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	such	such	JJ	JJ	_	23	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	tumor	tumor	NN	NN	_	23	compound	_	_
22	necrosis	necrosis	NN	NN	_	23	compound	_	_
23	factor-alpha	factor-alpha	NN	NN	_	17	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	interleukin-1	interleukin-1	NN	NN	_	26	compound	_	_
26	beta	beta	NN	NN	_	23	conj	_	_
27	,	,	,	,	_	23	punct	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	interleukin-6	interleukin-6	NN	NN	_	23	conj	_	_
30	by	by	IN	IN	_	31	mark	_	_
31	disrupting	disrupt	VBG	VBG	_	13	advcl	_	_
32	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	signaling	signaling	NN	NN	_	31	dobj	_	_
35	in	in	IN	IN	_	36	case	_	_
36	monocytes	monocyte	NNS	NNS	_	34	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BHRF1	bhrf1	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	2	acl	_	_
7	apoptosis	apoptosis	NN	NN	_	6	dobj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	dependent	dependent	JJ	JJ	_	0	root	_	_
10	on	on	IN	IN	_	11	case	_	_
11	stimulus	stimulus	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	type	type	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	development	development	NN	NN	_	30	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	resistance	resistance	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	host	host	NN	NN	_	8	compound	_	_
7	defense	defense	NN	NN	_	8	compound	_	_
8	mechanisms	mechanism	NNS	NNS	_	4	nmod	_	_
9	such	such	JJ	JJ	_	13	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	tumor	tumor	NN	NN	_	13	compound	_	_
12	necrosis	necrosis	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TNF	tnf	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	-	-	:	:	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	Fas-mediated	fas-mediated	JJ	JJ	_	13	conj	_	_
20	apoptosis	apoptosis	NN	NN	_	13	dep	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transformed	transform	VBN	VBN	_	13	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	virus-infected	virus-infected	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	conj	_	_
26	may	may	MD	MD	_	30	aux	_	_
27	be	be	VB	VB	_	30	cop	_	_
28	a	a	DT	DT	_	30	det	_	_
29	critical	critical	JJ	JJ	_	30	amod	_	_
30	component	component	NN	NN	_	0	root	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	development	development	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	disease	disease	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	30	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	find	find	VB	VB	_	0	root	_	_
3	genes	gene	NNS	NNS	_	2	dobj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	protect	protect	VBP	VBP	_	3	acl:relcl	_	_
6	cells	cell	NNS	NNS	_	5	dobj	_	_
7	from	from	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	used	use	VBD	VBD	_	2	parataxis	_	_
12	an	a	DT	DT	_	15	det	_	_
13	expression	expression	NN	NN	_	15	compound	_	_
14	cloning	cloning	NN	NN	_	15	compound	_	_
15	strategy	strategy	NN	NN	_	11	dobj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	identified	identify	VBD	VBD	_	11	conj	_	_
18	BHRF1	bhrf1	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	an	a	DT	DT	_	27	det	_	_
21	Epstein-Barr	epstein-barr	JJ	JJ	_	27	amod	_	_
22	virus	virus	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	EBV	ebv	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	27	punct	_	_
26	early-lytic-cycle	early-lytic-cycle	JJ	JJ	_	27	amod	_	_
27	protein	protein	NN	NN	_	18	appos	_	_
28	with	with	IN	IN	_	30	case	_	_
29	distant	distant	JJ	JJ	_	30	amod	_	_
30	homology	homology	NN	NN	_	27	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	Bcl-2	bcl-2	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	17	punct	_	_
34	as	as	IN	IN	_	37	case	_	_
35	an	a	DT	DT	_	37	det	_	_
36	anti-apoptosis	anti-apoptosis	JJ	JJ	_	37	amod	_	_
37	protein	protein	NN	NN	_	17	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	BHRF1	bhrf1	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	MCF-Fas	mcf-fas	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	conferred	confer	VBD	VBD	_	0	root	_	_
8	nearly	nearly	RB	RB	_	9	advmod	_	_
9	complete	complete	JJ	JJ	_	10	amod	_	_
10	resistance	resistance	NN	NN	_	7	dobj	_	_
11	against	against	IN	IN	_	14	case	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	anti-Fas	anti-fas	JJ	JJ	_	14	amod	_	_
14	antibody	antibody	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	TNF-mediated	tnf-mediated	JJ	JJ	_	17	amod	_	_
17	apoptosis	apoptosis	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	BHRF1	bhrf1	NN	NN	_	5	nsubj	_	_
5	protected	protect	VBD	VBD	_	0	root	_	_
6	these	these	DT	DT	_	7	det	_	_
7	cells	cell	NNS	NNS	_	5	dobj	_	_
8	from	from	IN	IN	_	10	case	_	_
9	monocyte-mediated	monocyte-mediated	JJ	JJ	_	10	amod	_	_
10	killing	killing	NN	NN	_	5	nmod	_	_
11	but	but	CC	CC	_	5	cc	_	_
12	failed	fail	VBD	VBD	_	5	conj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	protect	protect	VB	VB	_	12	xcomp	_	_
15	them	they	PRP	PRP	_	14	dobj	_	_
16	from	from	IN	IN	_	17	case	_	_
17	killing	killing	NN	NN	_	14	nmod	_	_
18	mediated	mediate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	22	case	_	_
20	lymphokine-activated	lymphokine-activated	JJ	JJ	_	22	amod	_	_
21	killer	killer	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BHRF1	bhrf1	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	protect	protect	VB	VB	_	2	acl	_	_
7	MCF-Fas	mcf-fas	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	6	dobj	_	_
9	from	from	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	various	various	JJ	JJ	_	14	amod	_	_
14	stimuli	stimulus	NNS	NNS	_	11	nmod	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	identical	identical	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Bcl-2	bcl-2	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Bcl-xL	bcl-xl	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	16	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	action	action	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	BHRF1	bhrf1	NN	NN	_	6	nmod	_	_
9	resembled	resemble	VBD	VBD	_	0	root	_	_
10	that	that	DT	DT	_	9	xcomp	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Bcl-2	bcl-2	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Bcl-xL	bcl-xl	NN	NN	_	12	conj	_	_
15	as	as	IN	IN	_	17	mark	_	_
16	it	it	PRP	PRP	_	17	nsubj	_	_
17	inhibited	inhibit	VBD	VBD	_	9	advcl	_	_
18	TNF-	tnf-	NN	NN	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	anti-Fas-induced	anti-fas-induced	JJ	JJ	_	18	conj	_	_
21	activation	activation	NN	NN	_	18	dep	_	_
22	of	of	IN	IN	_	24	case	_	_
23	two	two	CD	CD	_	24	nummod	_	_
24	enzymes	enzyme	NNS	NNS	_	18	nmod	_	_
25	participating	participate	VBG	VBG	_	24	acl	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	apoptosis	apoptosis	NN	NN	_	29	compound	_	_
29	pathway	pathway	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	24	punct	_	_
31	cytosolic	cytosolic	JJ	JJ	_	33	amod	_	_
32	phospholipase	phospholipase	NN	NN	_	33	compound	_	_
33	A2	a2	NN	NN	_	24	appos	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	caspase-3/CPP32	caspase-3/cpp32	NN	NN	_	33	conj	_	_
36	,	,	,	,	_	17	punct	_	_
37	but	but	CC	CC	_	17	cc	_	_
38	did	do	VBD	VBD	_	40	aux	_	_
39	not	not	RB	RB	_	40	neg	_	_
40	interfere	interfere	VB	VB	_	17	conj	_	_
41	with	with	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	activation	activation	NN	NN	_	40	nmod	_	_
44	of	of	IN	IN	_	47	case	_	_
45	NF-kappaB-like	nf-kappab-like	JJ	JJ	_	47	amod	_	_
46	transcription	transcription	NN	NN	_	47	compound	_	_
47	factors	factor	NNS	NNS	_	43	nmod	_	_
48	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	putative	putative	JJ	JJ	_	3	amod	_	_
3	function	function	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	BHRF1	bhrf1	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	EBV-infected	ebv-infected	JJ	JJ	_	9	amod	_	_
8	epithelial	epithelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	be	be	VB	VB	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	protect	protect	VB	VB	_	11	xcomp	_	_
14	virus-infected	virus-infected	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	13	dobj	_	_
16	from	from	IN	IN	_	17	case	_	_
17	TNF-	tnf-	NN	NN	_	13	nmod	_	_
18	and/or	and/or	CC	CC	_	17	cc	_	_
19	anti-Fas-induced	anti-fas-induced	JJ	JJ	_	17	conj	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	death	death	NN	NN	_	17	dep	_	_
22	in	in	IN	IN	_	25	mark	_	_
23	order	order	NN	NN	_	22	mwe	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	maximize	maximize	VB	VB	_	13	advcl	_	_
26	virus	virus	NN	NN	_	27	compound	_	_
27	production	production	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	11	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	expression	expression	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	neither	neither	CC	CC	_	6	cc:preconj	_	_
6	BHRF1	bhrf1	NN	NN	_	3	nmod	_	_
7	nor	nor	CC	CC	_	6	cc	_	_
8	Bcl-2	bcl-2	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	3	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	BJAB	bjab	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	3	punct	_	_
16	protected	protect	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	16	dobj	_	_
19	from	from	IN	IN	_	21	case	_	_
20	anti-Fas-mediated	anti-fas-mediated	JJ	JJ	_	21	amod	_	_
21	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
22	even	even	RB	RB	_	25	advmod	_	_
23	though	though	IN	IN	_	25	mark	_	_
24	they	they	PRP	PRP	_	25	nsubj	_	_
25	increased	increase	VBD	VBD	_	16	advcl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	survival	survival	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	serum-starved	serum-starved	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	protective	protective	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	BHRF1	bhrf1	NN	NN	_	5	nmod	_	_
8	against	against	IN	IN	_	9	case	_	_
9	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
10	resembles	resemble	VBZ	VBZ	_	0	root	_	_
11	that	that	DT	DT	_	10	xcomp	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Bcl-2	bcl-2	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	18	mark	_	_
15	being	be	VBG	VBG	_	18	cop	_	_
16	cell	cell	NN	NN	_	18	nmod:npmod	_	_
17	type	type	NN	NN	_	18	nmod:npmod	_	_
18	specific	specific	JJ	JJ	_	10	advcl	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	dependent	dependent	JJ	JJ	_	18	conj	_	_
21	on	on	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	apoptotic	apoptotic	JJ	JJ	_	24	amod	_	_
24	stimulus	stimulus	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	bcl-6	bcl-6	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	skin	skin	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	epidermal	epidermal	JJ	JJ	_	10	amod	_	_
10	neoplasms	neoplasm	NNS	NNS	_	7	conj	_	_
11	.	.	.	.	_	1	punct	_	_

1	Bcl-6	bcl-6	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	9	nsubj	_	_
3	is	be	VBZ	VBZ	_	9	cop	_	_
4	a	a	DT	DT	_	9	det	_	_
5	recently	recently	RB	RB	_	6	advmod	_	_
6	identified	identify	VBN	VBN	_	9	amod	_	_
7	novel	novel	JJ	JJ	_	6	dep	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	0	root	_	_
10	whose	whose	WP$	WP$	_	12	nmod:poss	_	_
11	deregulated	deregulate	VBN	VBN	_	12	amod	_	_
12	expression	expression	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	9	acl:relcl	_	_
15	with	with	IN	IN	_	20	case	_	_
16	diffuse	diffuse	JJ	JJ	_	17	amod	_	_
17	large	large	JJ	JJ	_	20	amod	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lymphomas	lymphoma	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	us	we	PRP	PRP	_	4	nmod	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	protein	protein	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	located	located	JJ	JJ	_	4	ccomp	_	_
12	in	in	IN	IN	_	16	case	_	_
13	germinal	germinal	JJ	JJ	_	16	amod	_	_
14	center	center	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
19	neoplastic	neoplastic	JJ	JJ	_	20	amod	_	_
20	counterparts	counterpart	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	35	nmod	_	_
5	,	,	,	,	_	35	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	35	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	bcl-6	bcl-6	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	7	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	normal	normal	JJ	JJ	_	13	amod	_	_
13	epidermis	epidermis	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	benign	benign	JJ	JJ	_	13	conj	_	_
16	,	,	,	,	_	15	punct	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	malignant	malignant	JJ	JJ	_	15	conj	_	_
19	tumors	tumor	NNS	NNS	_	15	dep	_	_
20	originating	originate	VBG	VBG	_	15	acl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	epidermal	epidermal	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	and	and	CC	CC	_	13	cc	_	_
26	squamous	squamous	JJ	JJ	_	33	amod	_	_
27	cell	cell	NN	NN	_	33	compound	_	_
28	carcinoma	carcinoma	NN	NN	_	33	compound	_	_
29	(	(	-LRB-	-LRB-	_	33	punct	_	_
30	SCC	scc	NN	NN	_	33	compound	_	_
31	)	)	-RRB-	-RRB-	_	33	punct	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	13	conj	_	_
34	are	be	VBP	VBP	_	35	auxpass	_	_
35	investigated	investigate	VBN	VBN	_	0	root	_	_
36	.	.	.	.	_	35	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	use	use	NN	NN	_	10	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	immunohistochemistry	immunohistochemistry	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	bcl-6	bcl-6	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	stain	stain	VB	VB	_	10	xcomp	_	_
13	intensely	intensely	RB	RB	_	19	advmod	_	_
14	on	on	IN	IN	_	17	case	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	prickle	prickle	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	19	nmod	_	_
18	,	,	,	,	_	19	punct	_	_
19	but	but	CC	CC	_	12	advmod	_	_
20	none	none	NN	NN	_	19	advmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	only	only	RB	RB	_	23	advmod	_	_
23	slightly	slightly	RB	RB	_	20	advcl	_	_
24	on	on	IN	IN	_	27	case	_	_
25	epidermal	epidermal	JJ	JJ	_	27	amod	_	_
26	basal	basal	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	19	conj	_	_
28	.	.	.	.	_	10	punct	_	_

1	Papillomas	papilloma	NNS	NNS	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	keratoacanthomas	keratoacanthoma	NNS	NNS	_	1	conj	_	_
4	copied	copy	VBD	VBD	_	0	root	_	_
5	their	they	PRP$	PRP$	_	7	nmod:poss	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	counterparts	counterpart	NNS	NNS	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	mode	mode	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Various	various	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	expression	expression	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	on	on	IN	IN	_	9	case	_	_
8	seborrheic	seborrheic	JJ	JJ	_	9	amod	_	_
9	keratoses	keratose	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	while	while	IN	IN	_	20	mark	_	_
12	the	the	DT	DT	_	14	det	_	_
13	expression	expression	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	20	nsubj	_	_
15	on	on	IN	IN	_	18	case	_	_
16	basal	basal	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	epitheliomas	epithelioma	NNS	NNS	_	14	nmod	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	low	low	JJ	JJ	_	6	advcl	_	_
21	.	.	.	.	_	6	punct	_	_

1	Peculiarly	peculiarly	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	eccrine	eccrine	JJ	JJ	_	4	amod	_	_
4	poromas	poroma	NNS	NNS	_	13	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	undifferentiated	undifferentiated	JJ	JJ	_	10	amod	_	_
7	spindle-shaped	spindle-shaped	JJ	JJ	_	6	dep	_	_
8	basal	basal	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	epitheliomas	epithelioma	NNS	NNS	_	4	conj	_	_
11	were	be	VBD	VBD	_	13	cop	_	_
12	totally	totally	RB	RB	_	13	advmod	_	_
13	unstained	unstained	JJ	JJ	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Squamous	squamous	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	carcinomas	carcinoma	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	variety	variety	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	while	while	IN	IN	_	22	mark	_	_
12	two	two	CD	CD	_	15	nummod	_	_
13	undifferentiated	undifferentiated	JJ	JJ	_	15	amod	_	_
14	spindle-shaped	spindle-shaped	JJ	JJ	_	13	dep	_	_
15	carcinomas	carcinoma	NNS	NNS	_	22	nsubj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	one	one	CD	CD	_	21	nummod	_	_
18	undifferentiated	undifferentiated	JJ	JJ	_	21	amod	_	_
19	SCC	scc	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	15	conj	_	_
22	remained	remain	VBD	VBD	_	4	advcl	_	_
23	unstained	unstained	JJ	JJ	_	22	xcomp	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	bcl-6	bcl-6	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	3	ccomp	_	_
13	with	with	IN	IN	_	15	case	_	_
14	morphological	morphological	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	normal	normal	JJ	JJ	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	neoplastic	neoplastic	JJ	JJ	_	21	amod	_	_
20	epidermal	epidermal	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Tissue	tissue	NN	NN	_	2	nmod:npmod	_	_
2	transglutaminase-dependent	transglutaminase-dependent	JJ	JJ	_	4	amod	_	_
3	posttranslational	posttranslational	JJ	JJ	_	2	dep	_	_
4	modification	modification	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	retinoblastoma	retinoblastoma	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	product	product	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	promonocytic	promonocytic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	undergoing	undergo	VBG	VBG	_	12	acl	_	_
14	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	retinoblastoma	retinoblastoma	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	pRB	prb	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	plays	play	VBZ	VBZ	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	controlling	control	VBG	VBG	_	8	advcl	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	release	release	NN	NN	_	13	dobj	_	_
17	from	from	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	G1	g1	NN	NN	_	20	compound	_	_
20	phase	phase	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	apoptosis	apoptosis	NN	NN	_	16	conj	_	_
23	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	early	early	JJ	JJ	_	8	amod	_	_
8	phases	phase	NNS	NNS	_	15	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	15	punct	_	_
12	pRB	prb	NN	NN	_	15	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	posttranslationally	posttranslationally	RB	RB	_	15	advmod	_	_
15	modified	modify	VBN	VBN	_	2	ccomp	_	_
16	by	by	IN	IN	_	24	case	_	_
17	a	a	DT	DT	_	24	det	_	_
18	tissue	tissue	NN	NN	_	24	compound	_	_
19	transglutaminase	transglutaminase	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	tTG	ttg	NN	NN	_	24	compound	_	_
22	)	)	-RRB-	-RRB-	_	24	punct	_	_
23	-catalyzed	-catalyzed	JJ	JJ	_	24	amod	_	_
24	reaction	reaction	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	by	by	IN	IN	_	5	mark	_	_
5	employing	employ	VBG	VBG	_	23	advcl	_	_
6	a	a	DT	DT	_	11	det	_	_
7	novel	novel	JJ	JJ	_	11	amod	_	_
8	haptenized	haptenize	VBN	VBN	_	11	amod	_	_
9	lysis	lysis	NN	NN	_	11	compound	_	_
10	synthetic	synthetic	JJ	JJ	_	11	amod	_	_
11	substrate	substrate	NN	NN	_	5	dobj	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	allows	allow	VBZ	VBZ	_	11	acl:relcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	isolation	isolation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	glutaminyl-tTG	glutaminyl-ttg	JJ	JJ	_	18	amod	_	_
18	substrates	substrate	NNS	NNS	_	15	nmod	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vivo	vivo	FW	FW	_	15	advmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	identified	identify	VBD	VBD	_	0	root	_	_
24	pRB	prb	NN	NN	_	23	dobj	_	_
25	as	as	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	potential	potential	JJ	JJ	_	29	amod	_	_
28	tTG	ttg	NN	NN	_	29	compound	_	_
29	substrate	substrate	NN	NN	_	23	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	U937	u937	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	undergoing	undergo	VBG	VBG	_	32	acl	_	_
34	apoptosis	apoptosis	NN	NN	_	33	dobj	_	_
35	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	2	mark	_	_
2	keeping	keep	VBG	VBG	_	8	advcl	_	_
3	with	with	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	finding	finding	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	apoptosis	apoptosis	NN	NN	_	15	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	U937	u937	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	characterized	characterize	VBN	VBN	_	8	ccomp	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	rapid	rapid	JJ	JJ	_	19	amod	_	_
19	disappearance	disappearance	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	105,000-	105,000-	CD	CD	_	24	compound	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	110,000-molecular-weight	110,000-molecular-weight	JJ	JJ	_	26	amod	_	_
25	pRB	prb	NN	NN	_	26	compound	_	_
26	forms	form	NNS	NNS	_	19	nmod	_	_
27	concomitantly	concomitantly	RB	RB	_	19	advmod	_	_
28	with	with	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	appearance	appearance	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	a	a	DT	DT	_	33	det	_	_
33	smear	smear	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	immunoreactive	immunoreactive	JJ	JJ	_	36	amod	_	_
36	products	product	NNS	NNS	_	33	nmod	_	_
37	with	with	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	molecular	molecular	JJ	JJ	_	40	amod	_	_
40	weight	weight	NN	NN	_	36	nmod	_	_
41	of	of	IN	IN	_	44	case	_	_
42	greater	greater	JJR	JJR	_	44	advmod	_	_
43	than	than	IN	IN	_	44	advmod	_	_
44	250,000	250,000	CD	CD	_	40	nmod	_	_
45	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	shift	shift	NN	NN	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	pRB	prb	NN	NN	_	6	compound	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	weight	weight	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	reproduced	reproduce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	adding	add	VBG	VBG	_	8	advcl	_	_
11	exogenous	exogenous	JJ	JJ	_	13	amod	_	_
12	purified	purify	VBN	VBN	_	13	amod	_	_
13	tTG	ttg	NN	NN	_	10	dobj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	extracts	extract	NNS	NNS	_	10	nmod	_	_
16	obtained	obtain	VBN	VBN	_	15	acl	_	_
17	from	from	IN	IN	_	20	case	_	_
18	viable	viable	JJ	JJ	_	20	amod	_	_
19	U937	u937	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	8	cc	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	prevented	prevent	VBN	VBN	_	8	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	dansylcadaverine	dansylcadaverine	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	a	a	DT	DT	_	30	det	_	_
28	potent	potent	JJ	JJ	_	30	amod	_	_
29	enzyme	enzyme	NN	NN	_	30	compound	_	_
30	inhibitor	inhibitor	NN	NN	_	25	appos	_	_
31	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	pRB	prb	NN	NN	_	7	compound	_	_
6	posttranslational	posttranslational	JJ	JJ	_	7	amod	_	_
7	modification	modification	NN	NN	_	2	nmod	_	_
8	during	during	IN	IN	_	9	case	_	_
9	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	investigated	investigate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	determining	determine	VBG	VBG	_	11	dep	_	_
14	the	the	DT	DT	_	16	det	_	_
15	E2F-1	e2f-1	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	13	dobj	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	isolating	isolate	VBG	VBG	_	13	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	characterizing	characterize	VBG	VBG	_	19	conj	_	_
22	pRB-null	prb-null	JJ	JJ	_	23	amod	_	_
23	clones	clone	NNS	NNS	_	19	dobj	_	_
24	from	from	IN	IN	_	26	case	_	_
25	U937	u937	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	Notably	notably	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	lack	lack	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	pRB	prb	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	these	these	DT	DT	_	10	det	_	_
9	U937-derived	u937-derived	JJ	JJ	_	10	amod	_	_
10	clones	clone	NNS	NNS	_	4	nmod	_	_
11	renders	render	VBZ	VBZ	_	0	root	_	_
12	these	these	DT	DT	_	14	det	_	_
13	p53-null	p53-null	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	16	nsubj	_	_
15	highly	highly	RB	RB	_	16	advmod	_	_
16	resistant	resistant	JJ	JJ	_	11	xcomp	_	_
17	to	to	TO	TO	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
19	induced	induce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	serum	serum	NN	NN	_	22	compound	_	_
22	withdrawal	withdrawal	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	calphostin	calphostin	NN	NN	_	25	compound	_	_
25	C	c	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	ceramide	ceramide	NN	NN	_	22	conj	_	_
29	.	.	.	.	_	11	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	tTG	ttg	NN	NN	_	17	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	acting	act	VBG	VBG	_	8	acl	_	_
11	on	on	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	pRB	prb	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	might	might	MD	MD	_	17	aux	_	_
17	play	play	VB	VB	_	6	ccomp	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	progression	progression	NN	NN	_	17	nmod	_	_
25	through	through	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	death	death	NN	NN	_	28	compound	_	_
28	program	program	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	1	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	that	that	IN	IN	_	5	mark	_	_
3	calcineurin	calcineurin	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	rate-limiting	rate-limiting	JJ	JJ	_	1	ccomp	_	_
6	for	for	IN	IN	_	10	case	_	_
7	primary	primary	JJ	JJ	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Cyclosporine	cyclosporine	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CsA	csa	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	both	both	CC	CC	_	10	cc:preconj	_	_
7	a	a	DT	DT	_	10	det	_	_
8	clinical	clinical	JJ	JJ	_	10	amod	_	_
9	immunosuppressive	immunosuppressive	JJ	JJ	_	8	dep	_	_
10	drug	drug	NN	NN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	a	a	DT	DT	_	13	det	_	_
13	probe	probe	NN	NN	_	10	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	dissect	dissect	VB	VB	_	13	acl	_	_
16	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathways	pathway	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	10	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	5	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	CsA	csa	NN	NN	_	5	nsubj	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	dobj	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	inhibiting	inhibit	VBG	VBG	_	5	advcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	phosphatase	phosphatase	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	calcineurin	calcineurin	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CN	cn	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	use	use	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	CsA	csa	NN	NN	_	6	compound	_	_
6	treatment	treatment	NN	NN	_	7	nsubj	_	_
7	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
8	50-75	50-75	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	CN	cn	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	circulating	circulate	VBG	VBG	_	15	amod	_	_
15	leukocytes	leukocyte	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	modeled	model	VBD	VBD	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	degree	degree	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	CN	cn	NN	NN	_	7	compound	_	_
7	inhibition	inhibition	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	2	advmod	_	_
14	in	in	IN	IN	_	17	mark	_	_
15	order	order	NN	NN	_	14	mwe	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	study	study	VB	VB	_	2	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	effect	effect	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	partial	partial	JJ	JJ	_	23	amod	_	_
22	CN	cn	NN	NN	_	23	compound	_	_
23	inhibition	inhibition	NN	NN	_	19	nmod	_	_
24	on	on	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	downstream	downstream	JJ	JJ	_	28	amod	_	_
27	signaling	signaling	NN	NN	_	28	compound	_	_
28	events	event	NNS	NNS	_	19	nmod	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	lead	lead	VBP	VBP	_	28	acl:relcl	_	_
31	to	to	TO	TO	_	33	case	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	CsA-treated	csa-treated	JJ	JJ	_	3	amod	_	_
3	leukocytes	leukocyte	NNS	NNS	_	17	nmod	_	_
4	stimulated	stimulate	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	calcium	calcium	NN	NN	_	7	compound	_	_
7	ionophore	ionophore	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	17	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	degree	degree	NN	NN	_	17	nsubjpass	_	_
11	of	of	IN	IN	_	12	case	_	_
12	reduction	reduction	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	CN	cn	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	accompanied	accompany	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	similar	similar	JJ	JJ	_	21	amod	_	_
21	degree	degree	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	inhibition	inhibition	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	each	each	DT	DT	_	26	det	_	_
26	event	event	NN	NN	_	23	nmod	_	_
27	tested	test	VBN	VBN	_	26	acl	_	_
28	:	:	:	:	_	17	punct	_	_
29	dephosphorylation	dephosphorylation	NN	NN	_	17	dep	_	_
30	of	of	IN	IN	_	37	case	_	_
31	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
32	factor	factor	NN	NN	_	37	compound	_	_
33	of	of	IN	IN	_	37	amod	_	_
34	activated	activate	VBN	VBN	_	37	amod	_	_
35	T	t	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	proteins	protein	NNS	NNS	_	29	nmod	_	_
38	,	,	,	,	_	29	punct	_	_
39	nuclear	nuclear	JJ	JJ	_	41	amod	_	_
40	DNA	dna	NN	NN	_	41	compound	_	_
41	binding	binding	NN	NN	_	29	conj	_	_
42	,	,	,	,	_	29	punct	_	_
43	activation	activation	NN	NN	_	29	conj	_	_
44	of	of	IN	IN	_	49	case	_	_
45	a	a	DT	DT	_	49	det	_	_
46	transfected	transfect	VBN	VBN	_	49	amod	_	_
47	reporter	reporter	NN	NN	_	49	compound	_	_
48	gene	gene	NN	NN	_	49	compound	_	_
49	construct	construct	NN	NN	_	43	nmod	_	_
50	,	,	,	,	_	29	punct	_	_
51	IFN-gamma	ifn-gamma	NN	NN	_	29	conj	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	IL-2	il-2	NN	NN	_	54	compound	_	_
54	mRNA	mrna	NN	NN	_	51	conj	_	_
55	accumulation	accumulation	NN	NN	_	51	dep	_	_
56	,	,	,	,	_	29	punct	_	_
57	and	and	CC	CC	_	29	cc	_	_
58	IFN-gamma	ifn-gamma	NN	NN	_	59	compound	_	_
59	production	production	NN	NN	_	29	conj	_	_
60	.	.	.	.	_	17	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	degree	degree	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	CN	cn	NN	NN	_	7	compound	_	_
7	inhibition	inhibition	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	reflected	reflect	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	similar	similar	JJ	JJ	_	13	amod	_	_
13	degree	degree	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	reduction	reduction	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	lymphocyte	lymphocyte	NN	NN	_	18	compound	_	_
18	proliferation	proliferation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	18	conj	_	_
22	in	in	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	allogeneic	allogeneic	JJ	JJ	_	27	amod	_	_
25	mixed	mixed	JJ	JJ	_	27	amod	_	_
26	lymphocyte	lymphocyte	NN	NN	_	27	compound	_	_
27	cultures	culture	NNS	NNS	_	18	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	conclusion	conclusion	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	CN	cn	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	rate-limiting	rate-limiting	JJ	JJ	_	5	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	primary	primary	JJ	JJ	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	reduction	reduction	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	CN	cn	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	observed	observe	VBN	VBN	_	4	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	CsA-treated	csa-treated	JJ	JJ	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	accompanied	accompany	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	similar	similar	JJ	JJ	_	17	amod	_	_
17	degree	degree	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	reduction	reduction	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	lymphocyte	lymphocyte	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	and	and	CC	CC	_	13	cc	_	_
26	accounts	account	VBZ	VBZ	_	13	conj	_	_
27	for	for	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	immunosuppression	immunosuppression	NN	NN	_	26	nmod	_	_
30	observed	observe	VBN	VBN	_	29	acl	_	_
31	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	domain	domain	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	A-MYB	a-myb	NN	NN	_	4	nmod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	7	dep	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	responsible	responsible	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	16	case	_	_
13	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell-specific	cell-specific	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	binds	bind	VBZ	VBZ	_	11	conj	_	_
19	to	to	TO	TO	_	25	case	_	_
20	a	a	DT	DT	_	25	det	_	_
21	B	b	NN	NN	_	25	compound	_	_
22	cell	cell	NN	NN	_	25	compound	_	_
23	110-kDa	110-kda	JJ	JJ	_	25	amod	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	12	nsubj	_	_
3	as	as	RB	RB	_	2	cc	_	_
4	well	well	RB	RB	_	3	mwe	_	_
5	as	as	IN	IN	_	3	mwe	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	2	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	transgenic	transgenic	JJ	JJ	_	10	amod	_	_
10	animals	animal	NNS	NNS	_	7	nmod	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	the	the	DT	DT	_	15	det	_	_
15	A-MYB	a-myb	NN	NN	_	18	nsubj	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	15	dep	_	_
18	plays	play	VBZ	VBZ	_	12	ccomp	_	_
19	central	central	JJ	JJ	_	22	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	specific	specific	JJ	JJ	_	19	conj	_	_
22	role	role	NN	NN	_	18	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	regulation	regulation	NN	NN	_	18	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	mature	mature	JJ	JJ	_	29	amod	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	cell	cell	NN	NN	_	25	nmod	_	_
30	proliferation	proliferation	NN	NN	_	29	dep	_	_
31	and/or	and/or	CC	CC	_	29	cc	_	_
32	differentiation	differentiation	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	highly	highly	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	Burkitt	burkitt	NN	NN	_	11	nmod:poss	_	_
9	's	's	POS	POS	_	11	case	_	_
10	lymphoma	lymphoma	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	participate	participate	VB	VB	_	6	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	pathogenesis	pathogenesis	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	disease	disease	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	A-MYB	a-myb	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	regulation	regulation	NN	NN	_	7	conj	_	_
13	in	in	IN	IN	_	18	case	_	_
14	several	several	JJ	JJ	_	18	amod	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	7	nmod	_	_
19	using	use	VBG	VBG	_	4	xcomp	_	_
20	co-transfection	co-transfection	NN	NN	_	21	compound	_	_
21	assays	assay	NNS	NNS	_	19	dobj	_	_
22	and	and	CC	CC	_	4	cc	_	_
23	show	show	VBP	VBP	_	4	conj	_	_
24	that	that	IN	IN	_	28	mark	_	_
25	A-MYB	a-myb	NN	NN	_	28	nsubj	_	_
26	is	be	VBZ	VBZ	_	28	cop	_	_
27	transcriptionally	transcriptionally	RB	RB	_	28	advmod	_	_
28	active	active	JJ	JJ	_	23	ccomp	_	_
29	in	in	IN	IN	_	34	case	_	_
30	all	all	PDT	PDT	_	34	dep	_	_
31	the	the	DT	DT	_	34	det	_	_
32	B	b	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	lines	line	NNS	NNS	_	28	nmod	_	_
35	studied	study	VBN	VBN	_	34	acl	_	_
36	,	,	,	,	_	34	punct	_	_
37	but	but	CC	CC	_	34	cc	_	_
38	not	not	RB	RB	_	41	neg	_	_
39	in	in	IN	IN	_	41	case	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	34	conj	_	_
42	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	14	nmod	_	_
3	the	the	DT	DT	_	7	det	_	_
4	best	best	JJS	JJS	_	7	amod	_	_
5	responder	responder	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	14	nsubj	_	_
8	was	be	VBD	VBD	_	14	cop	_	_
9	the	the	DT	DT	_	14	det	_	_
10	Burkitt	burkitt	NN	NN	_	14	nmod:poss	_	_
11	's	's	POS	POS	_	14	case	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	line	line	NN	NN	_	14	compound	_	_
14	Namalwa	namalwa	NN	NN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	A-MYB	a-myb	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	T	t	NN	NN	_	6	conj	_	_
10	cells	cell	NNS	NNS	_	6	dep	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	when	when	WRB	WRB	_	23	advmod	_	_
14	either	either	CC	CC	_	17	cc:preconj	_	_
15	an	a	DT	DT	_	17	det	_	_
16	artificial	artificial	JJ	JJ	_	17	amod	_	_
17	construct	construct	NN	NN	_	23	nsubjpass	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	21	det	_	_
20	c-MYC	c-myc	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	conj	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	used	use	VBN	VBN	_	12	advcl	_	_
24	as	as	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	reporter	reporter	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	domains	domain	NNS	NNS	_	25	nsubjpass	_	_
6	responsible	responsible	JJ	JJ	_	5	amod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	transactivation	transactivation	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	negative	negative	JJ	JJ	_	15	amod	_	_
15	regulation	regulation	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	previously	previously	RB	RB	_	18	advmod	_	_
18	characterized	characterize	VBN	VBN	_	5	acl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	fibroblast	fibroblast	NN	NN	_	22	compound	_	_
22	context	context	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	5	punct	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	found	find	VBN	VBN	_	0	root	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	have	have	VB	VB	_	25	xcomp	_	_
28	similar	similar	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	A-MYB	a-myb	NN	NN	_	2	nmod	_	_
5	responsible	responsible	JJ	JJ	_	2	amod	_	_
6	for	for	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	B	b	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	5	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	defined	define	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	20	mark	_	_
15	be	be	VB	VB	_	20	cop	_	_
16	the	the	DT	DT	_	20	det	_	_
17	N-terminal	n-terminal	JJ	JJ	_	20	amod	_	_
18	218	218	CD	CD	_	20	nummod	_	_
19	amino	amino	NN	NN	_	20	compound	_	_
20	acids	acid	NNS	NNS	_	13	xcomp	_	_
21	containing	contain	VBG	VBG	_	20	acl	_	_
22	the	the	DT	DT	_	25	det	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	domain	domain	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	13	punct	_	_

1	Finally	finally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	110-kDa	110-kda	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	nuclei	nucleus	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	all	all	PDT	PDT	_	15	dep	_	_
14	the	the	DT	DT	_	15	det	_	_
15	B	b	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	15	cc	_	_
19	T	t	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	15	conj	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	specifically	specifically	RB	RB	_	25	advmod	_	_
25	binds	bind	VBZ	VBZ	_	8	dep	_	_
26	to	to	TO	TO	_	30	case	_	_
27	this	this	DT	DT	_	30	det	_	_
28	A-MYB	a-myb	NN	NN	_	30	compound	_	_
29	N-terminal	n-terminal	JJ	JJ	_	30	amod	_	_
30	domain	domain	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesize	hypothesize	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	this	this	DT	DT	_	6	det	_	_
5	110-kDa	110-kda	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	14	nsubj	_	_
7	may	may	MD	MD	_	14	aux	_	_
8	be	be	VB	VB	_	14	cop	_	_
9	a	a	DT	DT	_	14	det	_	_
10	functionally	functionally	RB	RB	_	11	advmod	_	_
11	important	important	JJ	JJ	_	14	amod	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	cell-specific	cell-specific	JJ	JJ	_	14	amod	_	_
14	co-activator	co-activator	NN	NN	_	2	ccomp	_	_
15	of	of	IN	IN	_	16	case	_	_
16	A-MYB	a-myb	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	A-myb	a-myb	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	neoplastic	neoplastic	JJ	JJ	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	normal	normal	JJ	JJ	_	6	conj	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	dep	_	_
11	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	myb	myb	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	has	have	VBZ	VBZ	_	10	aux	_	_
8	been	be	VBN	VBN	_	10	auxpass	_	_
9	strongly	strongly	RB	RB	_	10	advmod	_	_
10	implicated	implicate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cell	cell	NN	NN	_	13	nmod	_	_
16	growth	growth	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	differentiation	differentiation	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	haematopoietic	haematopoietic	JJ	JJ	_	22	amod	_	_
22	system	system	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	v-myb	v-myb	NN	NN	_	3	compound	_	_
3	oncogene	oncogene	NN	NN	_	11	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	carried	carry	VBN	VBN	_	3	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	avian	avian	JJ	JJ	_	9	amod	_	_
8	defective	defective	JJ	JJ	_	9	amod	_	_
9	retroviruses	retrovirus	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	causes	cause	VBZ	VBZ	_	0	root	_	_
12	leukaemias	leukaemia	NNS	NNS	_	11	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	chicken	chicken	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	transforms	transform	VBZ	VBZ	_	11	conj	_	_
18	haematopoietic	haematopoietic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	17	dobj	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vitro	vitro	FW	FW	_	17	advmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	Its	its	PRP$	PRP$	_	4	nmod:poss	_	_
2	normal	normal	JJ	JJ	_	4	amod	_	_
3	cellular	cellular	JJ	JJ	_	4	amod	_	_
4	equivalent	equivalent	JJ	JJ	_	9	nsubjpass	_	_
5	c-myb	c-myb	NN	NN	_	4	dep	_	_
6	,	,	,	,	_	4	punct	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	promote	promote	VB	VB	_	9	xcomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	proliferation	proliferation	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	block	block	VB	VB	_	11	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	differentiation	differentiation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	haematopoietic	haematopoietic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	several	several	JJ	JJ	_	24	amod	_	_
23	experimental	experimental	JJ	JJ	_	24	amod	_	_
24	models	model	NNS	NNS	_	11	nmod	_	_
25	and	and	CC	CC	_	9	cc	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	required	require	VBN	VBN	_	9	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	fetal	fetal	JJ	JJ	_	30	amod	_	_
30	haematopoiesis	haematopoiesis	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	members	member	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	family	family	NN	NN	_	3	nmod	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	cloned	clone	VBN	VBN	_	0	root	_	_
10	more	more	RBR	RBR	_	11	advmod	_	_
11	recently	recently	RB	RB	_	9	advmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	A-myb	a-myb	NN	NN	_	9	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	B-myb	b-myb	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	show	show	VBP	VBP	_	13	acl:relcl	_	_
19	sequence	sequence	NN	NN	_	20	compound	_	_
20	homology	homology	NN	NN	_	18	dobj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	c-myb	c-myb	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	several	several	JJ	JJ	_	25	amod	_	_
25	domains	domain	NNS	NNS	_	18	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	of	of	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	32	nmod	_	_
29	the	the	DT	DT	_	32	det	_	_
30	DNA	dna	NN	NN	_	32	compound	_	_
31	binding	binding	NN	NN	_	32	compound	_	_
32	domain	domain	NN	NN	_	25	acl:relcl	_	_
33	as	as	RB	RB	_	32	cc	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	as	as	IN	IN	_	33	mwe	_	_
36	other	other	JJ	JJ	_	38	amod	_	_
37	regulatory	regulatory	JJ	JJ	_	38	amod	_	_
38	domains	domain	NNS	NNS	_	32	conj	_	_
39	.	.	.	.	_	9	punct	_	_

1	Both	both	DT	DT	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	xcomp	_	_
9	.	.	.	.	_	4	punct	_	_

1	B-myb	b-myb	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	involved	involve	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	control	control	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	proliferation	proliferation	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	differentiation	differentiation	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	4	punct	_	_
13	but	but	CC	CC	_	4	cc	_	_
14	,	,	,	,	_	4	punct	_	_
15	unlike	unlike	IN	IN	_	16	case	_	_
16	c-myb	c-myb	NN	NN	_	20	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	it	it	PRP	PRP	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	expressed	express	VBN	VBN	_	4	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	many	many	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	types	type	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	third	third	JJ	JJ	_	3	amod	_	_
3	member	member	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	family	family	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	A-myb	a-myb	NN	NN	_	3	appos	_	_
9	,	,	,	,	_	3	punct	_	_
10	shows	show	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	most	most	RBS	RBS	_	13	advmod	_	_
13	restricted	restricted	JJ	JJ	_	14	amod	_	_
14	pattern	pattern	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	expression	expression	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
19	a	a	DT	DT	_	22	det	_	_
20	very	very	RB	RB	_	21	advmod	_	_
21	specific	specific	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	18	dobj	_	_
23	for	for	IN	IN	_	26	case	_	_
24	this	this	DT	DT	_	26	det	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factor	factor	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	A-myb	a-myb	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subpopulation	subpopulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	normal	normal	JJ	JJ	_	10	amod	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	activated	activate	VBN	VBN	_	6	dep	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	11	advmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	localised	localised	JJ	JJ	_	11	conj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	germinal	germinal	JJ	JJ	_	19	amod	_	_
19	center	center	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
22	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
23	organs	organ	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	3	cc	_	_
25	is	be	VBZ	VBZ	_	27	auxpass	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	detected	detect	VBN	VBN	_	3	conj	_	_
28	at	at	IN	IN	_	30	case	_	_
29	significant	significant	JJ	JJ	_	30	amod	_	_
30	levels	level	NNS	NNS	_	27	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	all	all	DT	DT	_	34	dep	_	_
33	other	other	JJ	JJ	_	34	amod	_	_
34	mature	mature	JJ	JJ	_	27	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	immature	immature	JJ	JJ	_	38	amod	_	_
37	haematopoietic	haematopoietic	JJ	JJ	_	38	amod	_	_
38	populations	population	NNS	NNS	_	34	conj	_	_
39	studied	study	VBN	VBN	_	34	acl	_	_
40	,	,	,	,	_	34	punct	_	_
41	including	include	VBG	VBG	_	44	case	_	_
42	bone	bone	NN	NN	_	44	compound	_	_
43	marrow	marrow	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	34	nmod	_	_
45	,	,	,	,	_	44	punct	_	_
46	T	t	NN	NN	_	47	compound	_	_
47	lymphocytes	lymphocyte	NNS	NNS	_	44	appos	_	_
48	,	,	,	,	_	44	punct	_	_
49	granulocytes	granulocyte	NNS	NNS	_	44	appos	_	_
50	,	,	,	,	_	44	punct	_	_
51	monocytes	monocyte	NNS	NNS	_	44	appos	_	_
52	,	,	,	,	_	34	punct	_	_
53	either	either	CC	CC	_	55	cc:preconj	_	_
54	at	at	IN	IN	_	55	case	_	_
55	rest	rest	NN	NN	_	34	nmod	_	_
56	or	or	CC	CC	_	55	cc	_	_
57	after	after	RB	RB	_	60	advmod	_	_
58	in	in	FW	FW	_	60	amod	_	_
59	vitro	vitro	FW	FW	_	58	dep	_	_
60	activation	activation	NN	NN	_	55	conj	_	_
61	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	A-myb	a-myb	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	during	during	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	narrow	narrow	JJ	JJ	_	12	amod	_	_
12	window	window	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	normal	normal	JJ	JJ	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	differentiation	differentiation	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	A-myb	a-myb	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	6	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	6	aux	_	_
4	also	also	RB	RB	_	6	advmod	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	studied	study	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	wide	wide	JJ	JJ	_	10	amod	_	_
10	range	range	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	neoplastic	neoplastic	JJ	JJ	_	14	amod	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	representing	represent	VBG	VBG	_	10	acl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	whole	whole	JJ	JJ	_	19	amod	_	_
19	spectrum	spectrum	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	B	b	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	A-myb	a-myb	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	Burkitt	burkitt	NN	NN	_	8	nmod:poss	_	_
7	's	's	POS	POS	_	8	case	_	_
8	lymphomas	lymphoma	NNS	NNS	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	BL	bl	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	slg+	slg+	JJ	JJ	_	16	amod	_	_
14	B-acute	b-acute	JJ	JJ	_	16	amod	_	_
15	lymphoblastic	lymphoblastic	JJ	JJ	_	16	amod	_	_
16	leukaemias	leukaemia	NNS	NNS	_	8	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	B-ALL	b-all	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	not	not	RB	RB	_	25	neg	_	_
22	in	in	IN	IN	_	25	case	_	_
23	all	all	DT	DT	_	25	det	_	_
24	other	other	JJ	JJ	_	25	amod	_	_
25	leukaemias/lymphomas	leukaemias/lymphomas	NNS	NNS	_	8	conj	_	_
26	tested	test	VBN	VBN	_	25	acl	_	_
27	,	,	,	,	_	4	punct	_	_
28	with	with	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	exception	exception	NN	NN	_	4	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	a	a	DT	DT	_	33	det	_	_
33	subset	subset	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	CLL	cll	NN	NN	_	33	nmod	_	_
36	(	(	-LRB-	-LRB-	_	39	punct	_	_
37	about	about	RB	RB	_	38	advmod	_	_
38	25	25	CD	CD	_	39	nummod	_	_
39	%	%	NN	NN	_	30	dep	_	_
40	of	of	IN	IN	_	41	case	_	_
41	cases	case	NNS	NNS	_	39	nmod	_	_
42	)	)	-RRB-	-RRB-	_	39	punct	_	_
43	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	intriguing	intriguing	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	A-myb	a-myb	NN	NN	_	7	compound	_	_
7	genome	genome	NN	NN	_	10	nsubj	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	cop	_	_
10	localised	localised	JJ	JJ	_	3	ccomp	_	_
11	relatively	relatively	RB	RB	_	12	advmod	_	_
12	close	close	RB	RB	_	16	dep	_	_
13	to	to	TO	TO	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	c-myc	c-myc	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	10	nmod	_	_
17	on	on	IN	IN	_	18	case	_	_
18	chromosome	chromosome	NN	NN	_	16	nmod	_	_
19	8	8	CD	CD	_	18	nummod	_	_
20	,	,	,	,	_	3	punct	_	_
21	suggesting	suggest	VBG	VBG	_	3	xcomp	_	_
22	that	that	IN	IN	_	31	mark	_	_
23	the	the	DT	DT	_	25	det	_	_
24	c-myc	c-myc	NN	NN	_	25	compound	_	_
25	translocation	translocation	NN	NN	_	31	nsubj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	BL	bl	NNS	NNS	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	B-ALL	b-all	NNS	NNS	_	27	conj	_	_
30	may	may	MD	MD	_	31	aux	_	_
31	affect	affect	VB	VB	_	21	ccomp	_	_
32	A-myb	a-myb	NN	NN	_	33	compound	_	_
33	transcription	transcription	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	3	punct	_	_

1	Studies	study	NNS	NNS	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	in	in	IN	IN	_	4	case	_	_
4	progress	progress	NN	NN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	investigate	investigate	VB	VB	_	4	dep	_	_
7	the	the	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	relationship	relationship	NN	NN	_	6	dobj	_	_
10	between	between	IN	IN	_	11	case	_	_
11	A-myb	a-myb	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	c-myc	c-myc	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	9	punct	_	_
15	particularly	particularly	RB	RB	_	18	advmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	context	context	NN	NN	_	9	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	BL	bl	NNS	NNS	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	6	cc	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	determine	determine	VB	VB	_	6	conj	_	_
25	whether	whether	IN	IN	_	28	mark	_	_
26	A-myb	a-myb	NN	NN	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	deregulated	deregulate	VBN	VBN	_	24	ccomp	_	_
29	in	in	IN	IN	_	31	case	_	_
30	these	these	DT	DT	_	31	det	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	neutrophils	neutrophil	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	GH-N	gh-n	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcripts	transcript	NNS	NNS	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	11	det	_	_
9	pituitary	pituitary	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	conj	_	_
12	Pit-1b	pit-1b	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	3	mark	_	_
2	GH	gh	NN	NN	_	3	nsubj	_	_
3	stimulates	stimulate	VBZ	VBZ	_	12	advcl	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	development	development	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	function	function	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	granulocytes	granulocyte	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	investigated	investigate	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	GH	gh	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	granulocyte	granulocyte	JJ	JJ	_	19	amod	_	_
19	subsets	subset	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	immunocytochemistry	immunocytochemistry	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	25	25	CD	CD	_	7	nummod	_	_
5	+/-	+/-	CC	CC	_	4	cc	_	_
6	7	7	CD	CD	_	4	conj	_	_
7	%	%	NN	NN	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	shown	show	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	express	express	VB	VB	_	13	xcomp	_	_
16	immunoreactive	immunoreactive	JJ	JJ	_	17	amod	_	_
17	GH	gh	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	whereas	whereas	IN	IN	_	22	mark	_	_
20	eosinophils	eosinophil	NNS	NNS	_	22	nsubj	_	_
21	were	be	VBD	VBD	_	22	cop	_	_
22	negative	negative	JJ	JJ	_	13	advcl	_	_
23	.	.	.	.	_	13	punct	_	_

1	Reversed	reverse	VBN	VBN	_	7	amod	_	_
2	transcription	transcription	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	RT	rt	NN	NN	_	7	compound	_	_
5	)	)	-RRB-	-RRB-	_	7	punct	_	_
6	-PCR	-pcr	JJ	JJ	_	7	amod	_	_
7	analysis	analysis	NN	NN	_	8	nsubj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	GH	gh	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	neutrophils	neutrophil	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Restriction	restriction	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	neutrophils	neutrophil	NNS	NNS	_	6	nsubj	_	_
6	express	express	VBP	VBP	_	3	ccomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	GH-N	gh-n	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	6	dobj	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GH-V	gh-v	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	western	western	NN	NN	_	8	compound	_	_
7	blot	blot	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	4	nmod	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	neutrophils	neutrophil	NNS	NNS	_	11	nsubj	_	_
11	express	express	VBP	VBP	_	4	ccomp	_	_
12	an	a	DT	DT	_	15	det	_	_
13	alternatively	alternatively	RB	RB	_	14	advmod	_	_
14	spliced	splice	VBN	VBN	_	15	amod	_	_
15	variant	variant	NN	NN	_	11	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	pituitary	pituitary	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	15	nmod	_	_
21	Pit-1	pit-1	NN	NN	_	20	dep	_	_
22	,	,	,	,	_	15	punct	_	_
23	designated	designate	VBN	VBN	_	15	acl	_	_
24	Pit-1b	pit-1b	NN	NN	_	23	xcomp	_	_
25	.	.	.	.	_	4	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	myeloid-associated	myeloid-associated	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	hematopoietic	hematopoietic	JJ	JJ	_	9	amod	_	_
8	progenitor	progenitor	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	distribution	distribution	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	myeloid	myeloid	JJ	JJ	_	7	amod	_	_
5	lineage-associated	lineage-associated	JJ	JJ	_	7	amod	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	lysosomal	lysosomal	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	7	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	analyzed	analyze	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	22	case	_	_
14	human	human	JJ	JJ	_	22	amod	_	_
15	CD34+	cd34+	JJ	JJ	_	22	amod	_	_
16	cord	cord	NN	NN	_	22	compound	_	_
17	blood	blood	NN	NN	_	22	compound	_	_
18	cell	cell	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	CB	cb	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	subsets	subset	NNS	NNS	_	12	nmod	_	_
23	at	at	IN	IN	_	25	case	_	_
24	different	different	JJ	JJ	_	25	amod	_	_
25	stages	stage	NNS	NNS	_	12	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	myeloid	myeloid	JJ	JJ	_	28	amod	_	_
28	commitment	commitment	NN	NN	_	25	nmod	_	_
29	by	by	IN	IN	_	33	case	_	_
30	reverse-transcriptase	reverse-transcriptase	NN	NN	_	33	compound	_	_
31	polymerase	polymerase	NN	NN	_	33	compound	_	_
32	chain	chain	NN	NN	_	33	compound	_	_
33	reaction	reaction	NN	NN	_	12	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	RT-PCR	rt-pcr	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	highly	highly	RB	RB	_	3	advmod	_	_
3	specific	specific	JJ	JJ	_	6	amod	_	_
4	granulomonocyte-associated	granulomonocyte-associated	JJ	JJ	_	6	amod	_	_
5	lysosomal	lysosomal	JJ	JJ	_	6	amod	_	_
6	proteins	protein	NNS	NNS	_	27	nsubj	_	_
7	myeloperoxidase	myeloperoxidase	NN	NN	_	6	dep	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MPO	mpo	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	lysozyme	lysozyme	NN	NN	_	7	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LZ	lz	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	6	punct	_	_
17	as	as	RB	RB	_	6	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	6	conj	_	_
23	PU.1	pu.1	NN	NN	_	22	dep	_	_
24	,	,	,	,	_	6	punct	_	_
25	were	be	VBD	VBD	_	27	cop	_	_
26	already	already	RB	RB	_	27	advmod	_	_
27	detectable	detectable	JJ	JJ	_	0	root	_	_
28	in	in	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	most	most	RBS	RBS	_	31	advmod	_	_
31	immature	immature	JJ	JJ	_	33	amod	_	_
32	CD34+Thy-1+	cd34+thy-1+	JJ	JJ	_	33	amod	_	_
33	subset	subset	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	27	punct	_	_

1	Messenger	messenger	NN	NN	_	2	compound	_	_
2	RNA	rna	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	mRNA	mrna	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	levels	level	NNS	NNS	_	44	nsubjpass	_	_
7	for	for	IN	IN	_	15	case	_	_
8	the	the	DT	DT	_	15	det	_	_
9	granulocyte-colony	granulocyte-colony	NN	NN	_	15	compound	_	_
10	stimulating	stimulating	NN	NN	_	15	compound	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	G-CSF	g-csf	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	receptor	receptor	NN	NN	_	6	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	24	amod	_	_
18	(	(	-LRB-	-LRB-	_	24	punct	_	_
19	GM	gm	NN	NN	_	24	compound	_	_
20	)	)	-RRB-	-RRB-	_	24	punct	_	_
21	-CSF	-csf	NN	NN	_	24	compound	_	_
22	receptor	receptor	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	subunit	subunit	NN	NN	_	15	conj	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	tumor	tumor	NN	NN	_	28	compound	_	_
27	necrosis	necrosis	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TNF	tnf	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	receptors	receptor	NNS	NNS	_	15	conj	_	_
33	I	i	CD	CD	_	32	dep	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	p55	p55	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	and	and	CC	CC	_	32	cc	_	_
38	II	ii	CD	CD	_	32	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	p75	p75	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	were	be	VBD	VBD	_	44	auxpass	_	_
43	also	also	RB	RB	_	44	advmod	_	_
44	detected	detect	VBN	VBN	_	0	root	_	_
45	in	in	IN	IN	_	47	case	_	_
46	this	this	DT	DT	_	47	det	_	_
47	subset	subset	NN	NN	_	44	nmod	_	_
48	in	in	IN	IN	_	49	case	_	_
49	addition	addition	NN	NN	_	44	nmod	_	_
50	to	to	TO	TO	_	51	case	_	_
51	c-kit	c-kit	NN	NN	_	49	nmod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	flt-3	flt-3	NN	NN	_	51	conj	_	_
54	,	,	,	,	_	51	punct	_	_
55	receptors	receptor	NNS	NNS	_	51	appos	_	_
56	known	know	VBN	VBN	_	55	acl	_	_
57	to	to	TO	TO	_	59	mark	_	_
58	be	be	VB	VB	_	59	auxpass	_	_
59	expressed	express	VBN	VBN	_	56	xcomp	_	_
60	on	on	IN	IN	_	62	case	_	_
61	progenitor	progenitor	NN	NN	_	62	compound	_	_
62	cells	cell	NNS	NNS	_	59	nmod	_	_
63	.	.	.	.	_	44	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	the	the	DT	DT	_	12	det	_	_
5	monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	12	amod	_	_
6	colony	colony	NN	NN	_	12	compound	_	_
7	stimulating	stimulating	NN	NN	_	12	compound	_	_
8	factor	factor	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	M-CSF	m-csf	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	receptor	receptor	NN	NN	_	15	nsubj	_	_
13	was	be	VBD	VBD	_	15	cop	_	_
14	largely	largely	RB	RB	_	15	advmod	_	_
15	absent	absent	JJ	JJ	_	0	root	_	_
16	at	at	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	stage	stage	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	CD34+Thy-1-CD45RA-	cd34+thy-1-cd45ra-	JJ	JJ	_	23	amod	_	_
23	subsets	subset	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	M-CSF	m-csf	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	first	first	RB	RB	_	6	advmod	_	_
6	detectable	detectable	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	myeloid-committed	myeloid-committed	JJ	JJ	_	11	amod	_	_
10	CD34+Thy-l-CD45RA+	cd34+thy-l-cd45ra+	JJ	JJ	_	11	amod	_	_
11	subset	subset	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	molecules	molecule	NNS	NNS	_	6	nsubjpass	_	_
4	studied	study	VBN	VBN	_	3	acl	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	6	xcomp	_	_
10	at	at	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	stage	stage	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	differentiation	differentiation	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Different	different	JJ	JJ	_	2	amod	_	_
2	cocktails	cocktail	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	identified	identify	VBN	VBN	_	6	amod	_	_
6	ligands	ligand	NNS	NNS	_	2	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	added	add	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	13	case	_	_
10	sorted	sort	VBN	VBN	_	13	amod	_	_
11	CD34+Thy-1+	cd34+thy-1+	JJ	JJ	_	13	amod	_	_
12	single	single	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Low	low	JJ	JJ	_	3	amod	_	_
2	proliferative	proliferative	JJ	JJ	_	1	dep	_	_
3	capacity	capacity	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	after	after	IN	IN	_	8	case	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	week	week	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	culture	culture	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	stem	stem	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	SCF	scf	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	+	+	JJ	JJ	_	17	amod	_	_
22	Flt-3	flt-3	NN	NN	_	23	compound	_	_
23	ligand	ligand	NN	NN	_	17	dep	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	FL	fl	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	+	+	JJ	JJ	_	17	amod	_	_
28	G-CSF	g-csf	NN	NN	_	17	dep	_	_
29	.	.	.	.	_	5	punct	_	_

1	Addition	addition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	GM-CSF	gm-csf	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	this	this	DT	DT	_	7	det	_	_
6	basic	basic	JJ	JJ	_	7	amod	_	_
7	cocktail	cocktail	NN	NN	_	1	nmod	_	_
8	consistently	consistently	RB	RB	_	9	advmod	_	_
9	increased	increase	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	clonogenic	clonogenic	JJ	JJ	_	12	amod	_	_
12	capacity	capacity	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	single	single	JJ	JJ	_	16	amod	_	_
15	CD34+Thy-1+	cd34+thy-1+	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	this	this	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	23	nsubjpass	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	further	further	RB	RB	_	23	advmod	_	_
23	enhanced	enhance	VBN	VBN	_	9	conj	_	_
24	(	(	-LRB-	-LRB-	_	30	punct	_	_
25	up	up	RB	RB	_	27	advmod	_	_
26	to	to	TO	TO	_	27	dep	_	_
27	72.3	72.3	CD	CD	_	30	nummod	_	_
28	+/-	+/-	CC	CC	_	27	cc	_	_
29	4.3	4.3	CD	CD	_	27	conj	_	_
30	%	%	NN	NN	_	23	dep	_	_
31	on	on	IN	IN	_	30	case	_	_
32	day	day	NN	NN	_	30	dep	_	_
33	7	7	CD	CD	_	32	nummod	_	_
34	)	)	-RRB-	-RRB-	_	30	punct	_	_
35	by	by	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	inclusion	inclusion	NN	NN	_	23	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	TNF-alpha	tnf-alpha	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	18	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	myeloid-associated	myeloid-associated	JJ	JJ	_	11	amod	_	_
8	growth	growth	NN	NN	_	11	compound	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	transcripts	transcript	NNS	NNS	_	5	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	CD34+	cd34+	JJ	JJ	_	15	amod	_	_
14	CB	cb	NN	NN	_	15	compound	_	_
15	subsets	subset	NNS	NNS	_	5	nmod	_	_
16	does	do	VBZ	VBZ	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	discriminate	discriminate	VB	VB	_	0	root	_	_
19	the	the	DT	DT	_	21	det	_	_
20	various	various	JJ	JJ	_	21	amod	_	_
21	stages	stage	NNS	NNS	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	differentiation	differentiation	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	with	with	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	exception	exception	NN	NN	_	18	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	M-CSF	m-csf	NN	NN	_	31	compound	_	_
31	receptor	receptor	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	12	nsubj	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	potent	potent	JJ	JJ	_	12	amod	_	_
11	costimulatory	costimulatory	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	5	ccomp	_	_
13	of	of	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	very	very	RB	RB	_	19	advmod	_	_
16	immature	immature	JJ	JJ	_	19	amod	_	_
17	CD34+Thy-1+	cd34+thy-1+	JJ	JJ	_	19	amod	_	_
18	CB	cb	NN	NN	_	19	compound	_	_
19	subset	subset	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	5	det	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	function	function	NN	NN	_	1	conj	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	infection	infection	NN	NN	_	1	nmod	_	_
12	:	:	:	:	_	1	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	study	study	NN	NN	_	1	dep	_	_
15	in	in	IN	IN	_	16	case	_	_
16	hypercortisolemic	hypercortisolemic	JJ	JJ	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	cortisol-resistant	cortisol-resistant	JJ	JJ	_	16	conj	_	_
19	patients	patient	NNS	NNS	_	16	dep	_	_
20	.	.	.	.	_	1	punct	_	_

1	Immunological	immunological	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	12	nsubj	_	_
3	in	in	IN	IN	_	11	case	_	_
4	human	human	JJ	JJ	_	11	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
6	virus	virus	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	11	punct	_	_
8	HIV	hiv	NN	NN	_	11	compound	_	_
9	)	)	-RRB-	-RRB-	_	11	punct	_	_
10	-positive	-positive	JJ	JJ	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	2	nmod	_	_
12	suggest	suggest	VBP	VBP	_	0	root	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	disease	disease	NN	NN	_	16	compound	_	_
16	progression	progression	NN	NN	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	accompanied	accompany	VBN	VBN	_	12	ccomp	_	_
19	by	by	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	defective	defective	JJ	JJ	_	22	amod	_	_
22	production	production	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	type	type	NN	NN	_	22	nmod	_	_
25	1	1	CD	CD	_	26	nummod	_	_
26	cytokines	cytokine	NNS	NNS	_	24	dep	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	interleukin-2	interleukin-2	NN	NN	_	24	dep	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	IL-2	il-2	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	IL-12	il-12	NN	NN	_	28	conj	_	_
34	-RSB-	-rsb-	-RRB-	-RRB-	_	28	punct	_	_
35	,	,	,	,	_	22	punct	_	_
36	an	a	DT	DT	_	38	det	_	_
37	increased	increase	VBN	VBN	_	38	amod	_	_
38	production	production	NN	NN	_	22	conj	_	_
39	of	of	IN	IN	_	42	case	_	_
40	type	type	NN	NN	_	42	compound	_	_
41	2	2	CD	CD	_	42	nummod	_	_
42	cytokines	cytokine	NNS	NNS	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	IL-4	il-4	NN	NN	_	42	dep	_	_
45	,	,	,	,	_	44	punct	_	_
46	IL-6	il-6	NN	NN	_	44	conj	_	_
47	,	,	,	,	_	44	punct	_	_
48	and	and	CC	CC	_	44	cc	_	_
49	IL-10	il-10	NN	NN	_	44	conj	_	_
50	)	)	-RRB-	-RRB-	_	44	punct	_	_
51	,	,	,	,	_	22	punct	_	_
52	and	and	CC	CC	_	22	cc	_	_
53	an	a	DT	DT	_	55	det	_	_
54	increased	increase	VBN	VBN	_	55	amod	_	_
55	production	production	NN	NN	_	22	conj	_	_
56	of	of	IN	IN	_	57	case	_	_
57	IgE	ige	NN	NN	_	55	nmod	_	_
58	.	.	.	.	_	12	punct	_	_

1	HIV	hiv	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	activation	activation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	hypothalamo-pituitary-adrenal	hypothalamo-pituitary-adrenal	JJ	JJ	_	12	amod	_	_
11	axis	axis	NN	NN	_	12	compound	_	_
12	function	function	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	increased	increase	VBD	VBD	_	15	amod	_	_
15	plasma	plasma	NN	NN	_	7	conj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	urinary	urinary	JJ	JJ	_	15	conj	_	_
18	cortisol	cortisol	NN	NN	_	19	compound	_	_
19	concentrations	concentration	NNS	NNS	_	15	dep	_	_
20	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	4	mark	_	_
2	cortisol	cortisol	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	involved	involve	VBN	VBN	_	15	advcl	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	physiological	physiological	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
11	,	,	,	,	_	15	punct	_	_
12	a	a	DT	DT	_	13	det	_	_
13	study	study	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	conducted	conduct	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	examine	examine	VB	VB	_	15	dep	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	patterns	pattern	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	two	two	CD	CD	_	22	nummod	_	_
22	groups	group	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	hypercortisolemic	hypercortisolemic	JJ	JJ	_	25	amod	_	_
25	patients	patient	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	22	punct	_	_
27	one	one	CD	CD	_	22	appos	_	_
28	with	with	IN	IN	_	30	case	_	_
29	normal	normal	JJ	JJ	_	30	amod	_	_
30	sensitivity	sensitivity	NN	NN	_	27	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	glucocorticoids	glucocorticoid	NNS	NNS	_	30	nmod	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	the	the	DT	DT	_	35	det	_	_
35	other	other	JJ	JJ	_	27	conj	_	_
36	with	with	IN	IN	_	38	case	_	_
37	glucocorticoid	glucocorticoid	NN	NN	_	38	compound	_	_
38	resistance	resistance	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	15	punct	_	_

1	Ten	ten	CD	CD	_	3	nummod	_	_
2	HIV-infected	hiv-infected	JJ	JJ	_	3	amod	_	_
3	patients	patient	NNS	NNS	_	32	nsubjpass	_	_
4	with	with	IN	IN	_	7	case	_	_
5	normal	normal	JJ	JJ	_	7	amod	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	affinity	affinity	NN	NN	_	3	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AIDS-C	aids-c	NN	NN	_	3	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	3	punct	_	_
14	10	10	CD	CD	_	16	nummod	_	_
15	HIV-infected	hiv-infected	JJ	JJ	_	16	amod	_	_
16	patients	patient	NNS	NNS	_	3	conj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	low	low	JJ	JJ	_	20	amod	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	affinity	affinity	NN	NN	_	16	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	glucocorticoids	glucocorticoid	NNS	NNS	_	20	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	AIDS-GR	aids-gr	NN	NN	_	16	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	3	punct	_	_
27	and	and	CC	CC	_	3	cc	_	_
28	20	20	CD	CD	_	30	nummod	_	_
29	healthy	healthy	JJ	JJ	_	30	amod	_	_
30	subjects	subject	NNS	NNS	_	3	conj	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	studied	study	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	Receptor	receptor	NN	NN	_	2	compound	_	_
2	characteristics	characteristic	NNS	NNS	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	evaluated	evaluate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Serum	serum	NN	NN	_	2	compound	_	_
2	cortisol	cortisol	NN	NN	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	urinary	urinary	JJ	JJ	_	6	amod	_	_
5	free	free	JJ	JJ	_	6	amod	_	_
6	cortisol	cortisol	NN	NN	_	2	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	measured	measure	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	RIA	ria	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	Serum	serum	NN	NN	_	6	nsubjpass	_	_
2	ACTH	acth	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	IgE	ige	NN	NN	_	1	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	measured	measure	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	immunoradiometric	immunoradiometric	JJ	JJ	_	9	amod	_	_
9	assay	assay	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	IL-2	il-2	NN	NN	_	22	nsubjpass	_	_
13	,	,	,	,	_	12	punct	_	_
14	IL-4	il-4	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	IL-10	il-10	NN	NN	_	12	conj	_	_
18	cytokines	cytokine	NNS	NNS	_	12	dep	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	interferon-gamma	interferon-gamma	NN	NN	_	12	conj	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	measured	measure	VBN	VBN	_	6	conj	_	_
23	by	by	IN	IN	_	26	case	_	_
24	enzyme-linked	enzyme-linked	JJ	JJ	_	26	amod	_	_
25	immunosorbent	immunosorbent	JJ	JJ	_	24	dep	_	_
26	assay	assay	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	AIDS-C	aids-c	NN	NN	_	2	compound	_	_
2	patients	patient	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	low	low	JJ	JJ	_	5	amod	_	_
5	IL-2	il-2	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	IL-4	il-4	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	8	punct	_	_
10	IL-10	il-10	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	IgE	ige	NN	NN	_	8	conj	_	_
14	concentratios	concentratio	NNS	NNS	_	5	dep	_	_
15	;	;	:	:	_	3	punct	_	_
16	conversely	conversely	RB	RB	_	20	advmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	AIDS-GR	aids-gr	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	20	nsubj	_	_
20	showed	show	VBD	VBD	_	3	parataxis	_	_
21	high	high	JJ	JJ	_	22	amod	_	_
22	IL-2	il-2	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	low	low	JJ	JJ	_	25	amod	_	_
25	IL-4	il-4	NN	NN	_	22	conj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	IgE	ige	NN	NN	_	25	conj	_	_
28	concentrations	concentration	NNS	NNS	_	25	dep	_	_
29	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	HIV	hiv	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	elevated	elevated	JJ	JJ	_	9	amod	_	_
8	cortisol	cortisol	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	10	nsubj	_	_
10	suppress	suppress	VBP	VBP	_	0	root	_	_
11	cell-mediated	cell-mediated	JJ	JJ	_	12	amod	_	_
12	immunity	immunity	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	stimulate	stimulate	VBP	VBP	_	10	conj	_	_
15	humoral	humoral	JJ	JJ	_	16	amod	_	_
16	immunity	immunity	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	10	punct	_	_
18	whereas	whereas	IN	IN	_	23	mark	_	_
19	this	this	DT	DT	_	20	det	_	_
20	response	response	NN	NN	_	23	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	detected	detect	VBN	VBN	_	10	advcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	cortisol-resistant	cortisol-resistant	JJ	JJ	_	26	amod	_	_
26	patients	patient	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	cortisol	cortisol	NN	NN	_	11	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	receptors	receptor	NNS	NNS	_	5	conj	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	critically	critically	RB	RB	_	11	advmod	_	_
11	involved	involve	VBN	VBN	_	3	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	function	function	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	HIV	hiv	NN	NN	_	20	compound	_	_
20	infection	infection	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Dominant	dominant	JJ	JJ	_	5	amod	_	_
2	cytotoxic	cytotoxic	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	response	response	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	immediate-early	immediate-early	JJ	JJ	_	10	amod	_	_
9	trans-activator	trans-activator	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	BZLF1	bzlf1	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	5	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	persistent	persistent	JJ	JJ	_	16	amod	_	_
16	type	type	NN	NN	_	5	nmod	_	_
17	A	a	NN	NN	_	16	dep	_	_
18	or	or	CC	CC	_	16	cc	_	_
19	B	b	NN	NN	_	16	conj	_	_
20	Epstein-Barr	epstein-barr	JJ	JJ	_	22	amod	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	infection	infection	NN	NN	_	16	dep	_	_
23	.	.	.	.	_	5	punct	_	_

1	Five	five	CD	CD	_	11	nummod	_	_
2	healthy	healthy	JJ	JJ	_	11	amod	_	_
3	human	human	JJ	JJ	_	11	amod	_	_
4	leukocyte	leukocyte	NN	NN	_	11	compound	_	_
5	antigen-B8	antigen-b8	NN	NN	_	11	compound	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	HLA-B8	hla-b8	NN	NN	_	11	compound	_	_
8	)	)	-RRB-	-RRB-	_	11	punct	_	_
9	-positive	-positive	JJ	JJ	_	11	amod	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	carriers	carrier	NNS	NNS	_	13	nsubjpass	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	studied	study	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	investigate	investigate	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	20	det	_	_
17	CD8+	cd8+	JJ	JJ	_	20	amod	_	_
18	cytotoxic	cytotoxic	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocyte	lymphocyte	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	CTL	ctl	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	response	response	NN	NN	_	15	dobj	_	_
25	to	to	TO	TO	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	HLA-B8-restricted	hla-b8-restricted	JJ	JJ	_	28	amod	_	_
28	peptide	peptide	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	RAKFKQLLQ	rakfkqllq	NN	NN	_	28	appos	_	_
31	,	,	,	,	_	28	punct	_	_
32	located	located	JJ	JJ	_	28	amod	_	_
33	in	in	IN	IN	_	42	case	_	_
34	the	the	DT	DT	_	42	det	_	_
35	Epstein-Barr	epstein-barr	JJ	JJ	_	42	amod	_	_
36	virus	virus	NN	NN	_	42	compound	_	_
37	(	(	-LRB-	-LRB-	_	42	punct	_	_
38	EBV	ebv	NN	NN	_	42	compound	_	_
39	)	)	-RRB-	-RRB-	_	42	punct	_	_
40	immediate-early	immediate-early	JJ	JJ	_	42	amod	_	_
41	trans-activator	trans-activator	NN	NN	_	42	compound	_	_
42	protein	protein	NN	NN	_	32	nmod	_	_
43	,	,	,	,	_	42	punct	_	_
44	BZLF1	bzlf1	NN	NN	_	42	appos	_	_
45	.	.	.	.	_	13	punct	_	_

1	Of	of	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	5	5	CD	CD	_	5	nummod	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	carriers	carrier	NNS	NNS	_	9	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	4	4	CD	CD	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	infected	infect	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	type	type	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	1	1	CD	CD	_	9	conj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	type	type	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	EBV	ebv	NN	NN	_	14	dep	_	_
19	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	limiting-dilution	limiting-dilution	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	a	a	DT	DT	_	15	det	_	_
11	high	high	JJ	JJ	_	15	amod	_	_
12	RAKFKQLLQ-specific	rakfkqllq-specific	JJ	JJ	_	11	dep	_	_
13	CTL	ctl	NN	NN	_	15	compound	_	_
14	precursor	precursor	NN	NN	_	15	compound	_	_
15	frequency	frequency	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	demonstrated	demonstrate	VBN	VBN	_	1	parataxis	_	_
18	after	after	IN	IN	_	20	case	_	_
19	specific	specific	JJ	JJ	_	20	amod	_	_
20	peptide	peptide	NN	NN	_	17	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	autologous	autologous	JJ	JJ	_	25	amod	_	_
23	lymphoblastoid	lymphoblastoid	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	20	conj	_	_
26	stimulation	stimulation	NN	NN	_	20	dep	_	_
27	in	in	IN	IN	_	30	case	_	_
28	both	both	CC	CC	_	30	cc:preconj	_	_
29	type	type	NN	NN	_	30	compound	_	_
30	A	a	NN	NN	_	20	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	type	type	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	30	conj	_	_
34	EBV	ebv	NN	NN	_	35	compound	_	_
35	carriers	carrier	NNS	NNS	_	30	dep	_	_
36	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	RAKFKQLLQ-specific	rakfkqllq-specific	JJ	JJ	_	5	amod	_	_
3	CTL	ctl	NN	NN	_	5	compound	_	_
4	precursor	precursor	NN	NN	_	5	compound	_	_
5	frequencies	frequency	NNS	NNS	_	14	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	all	all	DT	DT	_	9	det	_	_
8	5	5	CD	CD	_	9	nummod	_	_
9	persons	person	NNS	NNS	_	5	nmod	_	_
10	were	be	VBD	VBD	_	14	cop	_	_
11	at	at	IN	IN	_	12	case	_	_
12	least	least	JJS	JJS	_	14	advmod	_	_
13	as	as	RB	RB	_	14	advmod	_	_
14	dominant	dominant	JJ	JJ	_	0	root	_	_
15	as	as	IN	IN	_	16	case	_	_
16	those	those	DT	DT	_	14	nmod	_	_
17	observed	observe	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	25	case	_	_
19	two	two	CD	CD	_	25	nummod	_	_
20	other	other	JJ	JJ	_	25	amod	_	_
21	EBV-associated	ebv-associated	JJ	JJ	_	25	amod	_	_
22	,	,	,	,	_	25	punct	_	_
23	HLA-B8-restricted	hla-b8-restricted	JJ	JJ	_	25	amod	_	_
24	latent	latent	JJ	JJ	_	25	amod	_	_
25	epitopes	epitope	NNS	NNS	_	17	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	FLRGRAYGL	flrgraygl	NN	NN	_	25	appos	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	QAKWRLQTL	qakwrlqtl	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	healthy	healthy	JJ	JJ	_	7	amod	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	carriers	carrier	NNS	NNS	_	8	nsubj	_	_
8	maintain	maintain	VBP	VBP	_	3	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	high	high	JJ	JJ	_	11	amod	_	_
11	frequency	frequency	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	BZLF1-specific	bzlf1-specific	JJ	JJ	_	16	amod	_	_
14	memory	memory	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	potentially	potentially	RB	RB	_	20	advmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	control	control	VB	VB	_	8	advcl	_	_
21	virus	virus	NN	NN	_	20	dobj	_	_
22	spread	spread	VBN	VBN	_	21	amod	_	_
23	from	from	IN	IN	_	26	case	_	_
24	lytically	lytically	RB	RB	_	26	advmod	_	_
25	infected	infected	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	characterization	characterization	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	pattern	pattern	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	tissue	tissue	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	gene	gene	NN	NN	_	7	nmod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	neutrophil	neutrophil	NN	NN	_	14	compound	_	_
13	gelatinase-associated	gelatinase-associated	JJ	JJ	_	14	amod	_	_
14	lipocalin	lipocalin	NN	NN	_	2	nmod	_	_
15	from	from	IN	IN	_	16	case	_	_
16	humans	human	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Neutrophil	neutrophil	NN	NN	_	3	compound	_	_
2	gelatinase-associated	gelatinase-associated	JJ	JJ	_	3	amod	_	_
3	lipocalin	lipocalin	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	NGAL	ngal	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	25-kDa	25-kda	JJ	JJ	_	10	amod	_	_
10	lipocalin	lipocalin	NN	NN	_	0	root	_	_
11	first	first	RB	RB	_	12	advmod	_	_
12	identified	identify	VBN	VBN	_	10	acl	_	_
13	as	as	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	protein	protein	NN	NN	_	12	nmod	_	_
16	stored	store	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	specific	specific	JJ	JJ	_	19	amod	_	_
19	granules	granule	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	neutrophil	neutrophil	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	believed	believe	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	bind	bind	VB	VB	_	4	xcomp	_	_
7	small	small	JJ	JJ	_	9	amod	_	_
8	lipophilic	lipophilic	JJ	JJ	_	9	amod	_	_
9	substances	substance	NNS	NNS	_	6	dobj	_	_
10	such	such	JJ	JJ	_	14	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	bacterial	bacterial	JJ	JJ	_	13	dep	_	_
13	derived	derive	VBN	VBN	_	14	amod	_	_
14	formylpeptides	formylpeptide	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	lipopolysaccharides	lipopolysaccharide	NNS	NNS	_	14	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	LPS	lp	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	might	might	MD	MD	_	4	conj	_	_
22	function	function	NN	NN	_	21	dobj	_	_
23	as	as	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	modulator	modulator	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	inflammation	inflammation	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NGAL	ngal	NN	NN	_	4	nmod	_	_
7	further	further	RB	RB	_	2	advmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	we	we	PRP	PRP	_	11	nsubj	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	cloned	clone	VBN	VBN	_	2	parataxis	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sequenced	sequence	VBN	VBN	_	11	conj	_	_
14	a	a	DT	DT	_	16	det	_	_
15	5869-bp	5869-bp	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	NGAL	ngal	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	including	include	VBG	VBG	_	23	case	_	_
22	1695	1695	CD	CD	_	23	nummod	_	_
23	bp	bp	NN	NN	_	16	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	5'	5'	JJ	JJ	_	28	amod	_	_
27	nontranscribed	nontranscribed	JJ	JJ	_	28	amod	_	_
28	region	region	NN	NN	_	23	nmod	_	_
29	and	and	CC	CC	_	23	cc	_	_
30	a	a	DT	DT	_	33	det	_	_
31	3696-bp	3696-bp	JJ	JJ	_	33	amod	_	_
32	coding	code	VBG	VBG	_	33	amod	_	_
33	region	region	NN	NN	_	23	conj	_	_
34	encompassing	encompass	VBG	VBG	_	33	acl	_	_
35	seven	seven	CD	CD	_	36	nummod	_	_
36	exons	exon	NNS	NNS	_	34	dobj	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	six	six	CD	CD	_	39	nummod	_	_
39	introns	intron	NNS	NNS	_	36	conj	_	_
40	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
3	start	start	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	an	a	DT	DT	_	11	det	_	_
9	RNase	rnase	NN	NN	_	11	compound	_	_
10	protection	protection	NN	NN	_	11	compound	_	_
11	assay	assay	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NGAL	ngal	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	highly	highly	RB	RB	_	6	advmod	_	_
6	homologous	homologous	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	mouse	mouse	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	24p3	24p3	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	NGAL	ngal	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	bone	bone	NN	NN	_	6	compound	_	_
6	marrow	marrow	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	in	in	IN	IN	_	9	case	_	_
9	tissues	tissue	NNS	NNS	_	6	conj	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	prone	prone	JJ	JJ	_	9	acl:relcl	_	_
13	to	to	TO	TO	_	14	case	_	_
14	exposure	exposure	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	microorganisms	microorganism	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Potential	potential	JJ	JJ	_	3	amod	_	_
2	cis-acting	cis-acting	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	region	region	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	NGAL	ngal	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	computer	computer	NN	NN	_	16	compound	_	_
16	analysis	analysis	NN	NN	_	5	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	include	include	VBP	VBP	_	5	conj	_	_
19	binding	bind	VBG	VBG	_	20	amod	_	_
20	sites	site	NNS	NNS	_	18	dobj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	CTF/CBP	ctf/cbp	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	the	the	DT	DT	_	27	det	_	_
25	hematopoietic	hematopoietic	JJ	JJ	_	27	amod	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	22	conj	_	_
28	GATA-1	gata-1	NN	NN	_	27	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	PU.1	pu.1	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	22	punct	_	_
32	and	and	CC	CC	_	22	cc	_	_
33	the	the	DT	DT	_	37	det	_	_
34	LPS-inducible	lps-inducible	JJ	JJ	_	37	amod	_	_
35	factor	factor	NN	NN	_	37	compound	_	_
36	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
37	B	b	NN	NN	_	22	conj	_	_
38	.	.	.	.	_	5	punct	_	_

1	Monocytic	monocytic	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	HL-60	hl-60	NN	NN	_	7	compound	_	_
5	promyelocytic	promyelocytic	JJ	JJ	_	7	amod	_	_
6	leukemia	leukemia	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	correlates	correlate	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Bcl-xL	bcl-xl	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Treatment	treatment	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	human	human	JJ	JJ	_	7	amod	_	_
4	promyelocytic	promyelocytic	JJ	JJ	_	7	amod	_	_
5	leukemia	leukemia	NN	NN	_	7	compound	_	_
6	HL-60	hl-60	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	phorbol	phorbol	NN	NN	_	10	compound	_	_
10	esters	ester	NNS	NNS	_	1	nmod	_	_
11	ultimately	ultimately	RB	RB	_	12	advmod	_	_
12	induces	induce	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	differentiation	differentiation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	along	along	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	monocyte/macrophage	monocyte/macrophage	NN	NN	_	21	compound	_	_
21	lineage	lineage	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	whereas	whereas	IN	IN	_	30	mark	_	_
24	treatment	treatment	NN	NN	_	30	nsubj	_	_
25	with	with	IN	IN	_	27	case	_	_
26	retinoic	retinoic	JJ	JJ	_	27	amod	_	_
27	acid	acid	NN	NN	_	24	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	DMSO	dmso	NN	NN	_	27	conj	_	_
30	induces	induce	VBZ	VBZ	_	12	advcl	_	_
31	granulocytic/neutrophillic	granulocytic/neutrophillic	JJ	JJ	_	32	amod	_	_
32	differentiation	differentiation	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	disparate	disparate	JJ	JJ	_	9	amod	_	_
9	fates	fate	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HL-60	hl-60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	treated	treat	VBN	VBN	_	12	acl	_	_
14	with	with	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	phorbol	phorbol	NN	NN	_	20	compound	_	_
17	ester	ester	NN	NN	_	20	compound	_	_
18	12,13-phorbol	12,13-phorbol	NN	NN	_	20	compound	_	_
19	dibutyric	dibutyric	JJ	JJ	_	20	amod	_	_
20	acid	acid	NN	NN	_	13	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	PDBu	pdbu	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	or	or	CC	CC	_	20	cc	_	_
25	DMSO	dmso	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	6	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	DMSO	dmso	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	HL-60	hl-60	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	8	nsubj	_	_
7	eventually	eventually	RB	RB	_	8	advmod	_	_
8	died	die	VBD	VBD	_	0	root	_	_
9	via	via	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	whereas	whereas	IN	IN	_	20	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	viability	viability	NN	NN	_	20	nsubjpass	_	_
15	of	of	IN	IN	_	17	case	_	_
16	PDBu-treated	pdbu-treated	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	was	be	VBD	VBD	_	20	auxpass	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	affected	affect	VBN	VBN	_	8	advcl	_	_
21	during	during	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	same	same	JJ	JJ	_	24	amod	_	_
24	interval	interval	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	apoptosis	apoptosis	NN	NN	_	7	compound	_	_
6	effector	effector	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	2	nmod	_	_
8	Bak	bak	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Bad	bad	NN	NN	_	8	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	enhanced	enhance	VBN	VBN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	whereas	whereas	IN	IN	_	16	mark	_	_
15	there	there	EX	EX	_	16	expl	_	_
16	was	be	VBD	VBD	_	12	advcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	slight	slight	JJ	JJ	_	19	amod	_	_
19	down-regulation	down-regulation	NN	NN	_	16	nsubj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	apoptosis	apoptosis	NN	NN	_	24	compound	_	_
23	suppressor	suppressor	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	19	nmod	_	_
25	Bcl-2	bcl-2	NN	NN	_	24	dep	_	_
26	after	after	IN	IN	_	27	case	_	_
27	treatment	treatment	NN	NN	_	16	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	with	with	IN	IN	_	32	case	_	_
32	PDBu	pdbu	NN	NN	_	27	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	DMSO	dmso	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	12	punct	_	_

1	Treatment	treatment	NN	NN	_	4	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	DMSO	dmso	NN	NN	_	1	nmod	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	elevation	elevation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	apoptosis	apoptosis	NN	NN	_	11	compound	_	_
11	effector	effector	NN	NN	_	7	nmod	_	_
12	Bax	bax	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	4	punct	_	_
14	whereas	whereas	IN	IN	_	21	mark	_	_
15	treatment	treatment	NN	NN	_	21	nsubj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	PDBu	pdbu	NN	NN	_	15	nmod	_	_
18	did	do	VBD	VBD	_	21	aux	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	significantly	significantly	RB	RB	_	21	advmod	_	_
21	alter	alter	VB	VB	_	4	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	levels	level	NNS	NNS	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	protein	protein	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	treatment	treatment	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	HL-60	hl-60	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	PDBu	pdbu	NN	NN	_	3	nmod	_	_
9	induced	induce	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	rapid	rapid	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	apoptosis	apoptosis	NN	NN	_	17	compound	_	_
16	suppressor	suppressor	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	12	nmod	_	_
18	Bcl-xL	bcl-xl	NN	NN	_	17	dep	_	_
19	,	,	,	,	_	9	punct	_	_
20	whereas	whereas	IN	IN	_	26	mark	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	26	nsubj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	protein	protein	NN	NN	_	22	nmod	_	_
26	remained	remain	VBD	VBD	_	9	advcl	_	_
27	unaltered	unaltered	JJ	JJ	_	26	xcomp	_	_
28	in	in	IN	IN	_	30	case	_	_
29	DMSO-treated	dmso-treated	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	generality	generality	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	finding	finding	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	confirmed	confirm	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Bcl-xL	bcl-xl	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
16	U-937	u-937	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	monocytes	monocyte	NNS	NNS	_	17	conj	_	_
23	exposed	expose	VBN	VBN	_	22	acl	_	_
24	to	to	TO	TO	_	26	case	_	_
25	phorbol	phorbol	NN	NN	_	26	compound	_	_
26	ester	ester	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	mouse	mouse	NN	NN	_	30	nmod:npmod	_	_
30	thioglycollate-activated	thioglycollate-activated	JJ	JJ	_	17	conj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	resident	resident	JJ	JJ	_	34	amod	_	_
33	peritoneal	peritoneal	JJ	JJ	_	34	amod	_	_
34	macrophages	macrophage	NNS	NNS	_	30	conj	_	_
35	.	.	.	.	_	7	punct	_	_

1	PDBu-treated	pdbu-treated	JJ	JJ	_	3	amod	_	_
2	HL-60	hl-60	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	remained	remain	VBD	VBD	_	0	root	_	_
5	viable	viable	JJ	JJ	_	4	xcomp	_	_
6	for	for	IN	IN	_	8	case	_	_
7	7	7	CD	CD	_	8	nummod	_	_
8	days	day	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	thereafter	thereafter	RB	RB	_	11	advmod	_	_
11	began	begin	VBD	VBD	_	4	conj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	die	die	VB	VB	_	11	xcomp	_	_
14	via	via	IN	IN	_	15	case	_	_
15	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	with	with	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	concomitant	concomitant	JJ	JJ	_	20	amod	_	_
20	down-regulation	down-regulation	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Bcl-xL	bcl-xl	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	propose	propose	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	Bcl-xL	bcl-xl	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	5	ccomp	_	_
11	with	with	IN	IN	_	12	case	_	_
12	differentiation	differentiation	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	survival	survival	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	hematopoietic	hematopoietic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	along	along	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	monocyte/macrophage	monocyte/macrophage	NN	NN	_	21	compound	_	_
21	lineage	lineage	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	spatial	spatial	JJ	JJ	_	3	amod	_	_
3	distribution	distribution	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	immunoglobulin	immunoglobulin	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	3	nmod	_	_
8	within	within	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nucleus	nucleus	NN	NN	_	3	nmod	_	_
11	:	:	:	:	_	3	punct	_	_
12	evidence	evidence	NN	NN	_	3	dep	_	_
13	for	for	IN	IN	_	15	case	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	topography	topography	NN	NN	_	12	nmod	_	_
16	independent	independent	JJ	JJ	_	15	amod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	type	type	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activity	activity	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	three-dimensional	three-dimensional	JJ	JJ	_	3	amod	_	_
3	positioning	positioning	NN	NN	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	Ig	ig	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	genes	gene	NNS	NNS	_	3	nmod	_	_
10	within	within	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	nucleus	nucleus	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	investigated	investigate	VBN	VBN	_	0	root	_	_
18	using	use	VBG	VBG	_	17	xcomp	_	_
19	in	in	FW	FW	_	21	amod	_	_
20	situ	situ	FW	FW	_	19	dep	_	_
21	hybridization	hybridization	NN	NN	_	18	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	confocal	confocal	JJ	JJ	_	24	amod	_	_
24	microscopy	microscopy	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	visualization	visualization	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	heavy	heavy	JJ	JJ	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	light	light	JJ	JJ	_	4	conj	_	_
7	chain	chain	NN	NN	_	8	compound	_	_
8	genes	gene	NNS	NNS	_	4	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B-lymphoid	b-lymphoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	22	mark	_	_
14	the	the	DT	DT	_	17	det	_	_
15	three	three	CD	CD	_	17	nummod	_	_
16	Ig	ig	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	22	nsubjpass	_	_
18	are	be	VBP	VBP	_	22	auxpass	_	_
19	differentially	differentially	RB	RB	_	20	advmod	_	_
20	and	and	CC	CC	_	22	advmod	_	_
21	nonrandomly	nonrandomly	RB	RB	_	20	advmod	_	_
22	distributed	distribute	VBN	VBN	_	12	ccomp	_	_
23	in	in	IN	IN	_	26	case	_	_
24	different	different	JJ	JJ	_	26	amod	_	_
25	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
26	subvolumes	subvolume	NNS	NNS	_	22	nmod	_	_
27	:	:	:	:	_	12	punct	_	_
28	the	the	DT	DT	_	30	det	_	_
29	kappa	kappa	NN	NN	_	30	compound	_	_
30	genes	gene	NNS	NNS	_	32	nsubjpass	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	found	find	VBN	VBN	_	12	parataxis	_	_
33	to	to	TO	TO	_	36	mark	_	_
34	be	be	VB	VB	_	36	auxpass	_	_
35	preferentially	preferentially	RB	RB	_	36	advmod	_	_
36	confined	confine	VBN	VBN	_	32	xcomp	_	_
37	to	to	TO	TO	_	41	case	_	_
38	an	a	DT	DT	_	41	det	_	_
39	outer	outer	JJ	JJ	_	41	amod	_	_
40	nuclear	nuclear	JJ	JJ	_	41	amod	_	_
41	volume	volume	NN	NN	_	36	nmod	_	_
42	,	,	,	,	_	32	punct	_	_
43	whereas	whereas	IN	IN	_	50	mark	_	_
44	the	the	DT	DT	_	45	dep	_	_
45	gamma	gamma	NN	NN	_	50	nsubj	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	lambda	lambda	NN	NN	_	45	conj	_	_
48	genes	gene	NNS	NNS	_	45	dep	_	_
49	consistently	consistently	RB	RB	_	50	advmod	_	_
50	occupied	occupy	VBD	VBD	_	32	advcl	_	_
51	more	more	RBR	RBR	_	52	advmod	_	_
52	central	central	JJ	JJ	_	53	amod	_	_
53	positions	position	NNS	NNS	_	50	dobj	_	_
54	within	within	IN	IN	_	56	case	_	_
55	the	the	DT	DT	_	56	det	_	_
56	nucleus	nucleus	NN	NN	_	53	nmod	_	_
57	,	,	,	,	_	50	punct	_	_
58	the	the	DT	DT	_	60	det	_	_
59	lambda	lambda	NN	NN	_	60	compound	_	_
60	genes	gene	NNS	NNS	_	63	nsubj	_	_
61	being	be	VBG	VBG	_	63	cop	_	_
62	more	more	RBR	RBR	_	63	advmod	_	_
63	interior	interior	JJ	JJ	_	50	advcl	_	_
64	when	when	WRB	WRB	_	65	advmod	_	_
65	compared	compare	VBN	VBN	_	63	advcl	_	_
66	with	with	IN	IN	_	69	case	_	_
67	the	the	DT	DT	_	69	det	_	_
68	gamma	gamma	NN	NN	_	69	compound	_	_
69	genes	gene	NNS	NNS	_	65	nmod	_	_
70	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	further	further	RB	RB	_	4	advmod	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	these	these	DT	DT	_	9	det	_	_
7	overall	overall	JJ	JJ	_	9	amod	_	_
8	topographical	topographical	JJ	JJ	_	7	dep	_	_
9	distributions	distribution	NNS	NNS	_	11	nsubj	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	independent	independent	JJ	JJ	_	4	ccomp	_	_
12	of	of	IN	IN	_	15	case	_	_
13	gene	gene	NN	NN	_	15	compound	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	conserved	conserve	VBN	VBN	_	11	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	different	different	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	types	type	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	subtle	subtle	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	movements	movement	NNS	NNS	_	13	nsubjpass	_	_
5	within	within	IN	IN	_	9	case	_	_
6	those	those	DT	DT	_	9	det	_	_
7	defined	define	VBN	VBN	_	9	amod	_	_
8	topographical	topographical	JJ	JJ	_	7	dep	_	_
9	regions	region	NNS	NNS	_	4	nmod	_	_
10	can	can	MD	MD	_	13	aux	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	excluded	exclude	VBN	VBN	_	20	advcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	study	study	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	the	the	DT	DT	_	19	det	_	_
19	results	result	NNS	NNS	_	20	nsubj	_	_
20	indicate	indicate	VBP	VBP	_	0	root	_	_
21	that	that	IN	IN	_	29	mark	_	_
22	tissue	tissue	NN	NN	_	23	compound	_	_
23	specificity	specificity	NN	NN	_	29	nsubjpass	_	_
24	of	of	IN	IN	_	26	case	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	accompanied	accompany	VBN	VBN	_	20	ccomp	_	_
30	by	by	IN	IN	_	32	case	_	_
31	drastic	drastic	JJ	JJ	_	32	amod	_	_
32	changes	change	NNS	NNS	_	29	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	gene	gene	NN	NN	_	36	compound	_	_
35	nuclear	nuclear	JJ	JJ	_	36	amod	_	_
36	topography	topography	NN	NN	_	32	nmod	_	_
37	,	,	,	,	_	20	punct	_	_
38	rather	rather	RB	RB	_	39	advmod	_	_
39	suggesting	suggest	VBG	VBG	_	20	xcomp	_	_
40	that	that	IN	IN	_	49	mark	_	_
41	gene	gene	NN	NN	_	42	compound	_	_
42	organization	organization	NN	NN	_	49	nsubj	_	_
43	within	within	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	nucleus	nucleus	NN	NN	_	42	nmod	_	_
46	may	may	MD	MD	_	49	aux	_	_
47	be	be	VB	VB	_	49	cop	_	_
48	primarily	primarily	RB	RB	_	49	advmod	_	_
49	dependent	dependent	JJ	JJ	_	39	ccomp	_	_
50	on	on	IN	IN	_	52	case	_	_
51	structural	structural	JJ	JJ	_	52	amod	_	_
52	constraints	constraint	NNS	NNS	_	49	nmod	_	_
53	imposed	impose	VBN	VBN	_	52	acl	_	_
54	on	on	IN	IN	_	57	case	_	_
55	the	the	DT	DT	_	57	det	_	_
56	respective	respective	JJ	JJ	_	57	amod	_	_
57	chromosomes	chromosome	NNS	NNS	_	53	nmod	_	_
58	.	.	.	.	_	20	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	4	nsubj	_	_
3	EBNA3C	ebna3c	NN	NN	_	2	dep	_	_
4	represses	repress	VBZ	VBZ	_	0	root	_	_
5	Cp	cp	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	major	major	JJ	JJ	_	9	amod	_	_
9	promoter	promoter	NN	NN	_	5	appos	_	_
10	for	for	IN	IN	_	12	case	_	_
11	EBNA	ebna	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	but	but	CC	CC	_	4	cc	_	_
15	has	have	VBZ	VBZ	_	4	conj	_	_
16	no	no	DT	DT	_	17	neg	_	_
17	effect	effect	NN	NN	_	15	dobj	_	_
18	on	on	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	promoter	promoter	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	CD21	cd21	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	EBNA3C	ebna3c	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potent	potent	JJ	JJ	_	5	amod	_	_
5	repressor	repressor	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	transcription	transcription	NN	NN	_	5	nmod	_	_
8	when	when	WRB	WRB	_	9	advmod	_	_
9	bound	bind	VBN	VBN	_	5	advcl	_	_
10	to	to	TO	TO	_	11	case	_	_
11	DNA	dna	NN	NN	_	9	nmod	_	_
12	as	as	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	fusion	fusion	NN	NN	_	9	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	DNA	dna	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	DBD	dbd	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	of	of	IN	IN	_	24	case	_	_
24	GALA	gala	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	survey	survey	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	promoters	promoter	NNS	NNS	_	2	nmod	_	_
5	has	have	VBZ	VBZ	_	6	aux	_	_
6	revealed	reveal	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	the	the	DT	DT	_	12	det	_	_
9	wild-type	wild-type	JJ	JJ	_	12	amod	_	_
10	,	,	,	,	_	12	punct	_	_
11	unfused	unfused	JJ	JJ	_	12	amod	_	_
12	EBNA3C	ebna3c	NN	NN	_	15	nsubj	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	specifically	specifically	RB	RB	_	15	advmod	_	_
15	repress	repress	VB	VB	_	6	ccomp	_	_
16	expression	expression	NN	NN	_	15	dobj	_	_
17	from	from	IN	IN	_	19	case	_	_
18	reporter	reporter	NN	NN	_	19	compound	_	_
19	plasmids	plasmid	NNS	NNS	_	16	nmod	_	_
20	containing	contain	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	Epstein-Barr	epstein-barr	JJ	JJ	_	23	amod	_	_
23	virus	virus	NN	NN	_	20	dobj	_	_
24	Cp	cp	NN	NN	_	26	compound	_	_
25	latency-associated	latency-associated	JJ	JJ	_	26	amod	_	_
26	promoter	promoter	NN	NN	_	23	dep	_	_
27	.	.	.	.	_	6	punct	_	_

1	Repression	repression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Cp	cp	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	required	require	VBD	VBD	_	0	root	_	_
6	amino	amino	NN	NN	_	7	compound	_	_
7	acids	acid	NNS	NNS	_	5	dobj	_	_
8	207	207	CD	CD	_	7	nummod	_	_
9	to	to	TO	TO	_	7	dep	_	_
10	368	368	CD	CD	_	7	nummod	_	_
11	,	,	,	,	_	7	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	encompasses	encompass	VBZ	VBZ	_	7	acl:relcl	_	_
14	a	a	DT	DT	_	15	det	_	_
15	region	region	NN	NN	_	13	dobj	_	_
16	resembling	resemble	VBG	VBG	_	15	acl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	basic	basic	JJ	JJ	_	19	amod	_	_
19	DBD	dbd	NN	NN	_	16	xcomp	_	_
20	adjacent	adjacent	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	27	case	_	_
22	a	a	DT	DT	_	27	det	_	_
23	leucine	leucine	NN	NN	_	27	compound	_	_
24	zipper	zipper	NN	NN	_	27	compound	_	_
25	DNA	dna	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	motif	motif	NN	NN	_	20	nmod	_	_
28	and	and	CC	CC	_	15	cc	_	_
29	a	a	DT	DT	_	30	det	_	_
30	site	site	NN	NN	_	15	conj	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	binds	bind	VBZ	VBZ	_	30	acl:relcl	_	_
33	to	to	TO	TO	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	cellular	cellular	JJ	JJ	_	37	amod	_	_
36	factor	factor	NN	NN	_	37	compound	_	_
37	CBF1/RBP-Jkappa	cbf1/rbp-jkappa	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	amino	amino	NN	NN	_	4	compound	_	_
4	acids	acid	NNS	NNS	_	9	nsubj	_	_
5	207	207	CD	CD	_	4	nummod	_	_
6	to	to	TO	TO	_	4	dep	_	_
7	368	368	CD	CD	_	4	nummod	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	dispensable	dispensable	JJ	JJ	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	the	the	DT	DT	_	12	det	_	_
12	protein	protein	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	bound	bind	VBN	VBN	_	9	advcl	_	_
15	to	to	TO	TO	_	16	case	_	_
16	DNA	dna	NN	NN	_	14	nmod	_	_
17	as	as	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	fusion	fusion	NN	NN	_	14	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	GAL4	gal4	NN	NN	_	19	nmod	_	_
23	DBD	dbd	NN	NN	_	22	dep	_	_
24	,	,	,	,	_	9	punct	_	_
25	thus	thus	RB	RB	_	26	advmod	_	_
26	implicating	implicate	VBG	VBG	_	9	xcomp	_	_
27	this	this	DT	DT	_	28	det	_	_
28	region	region	NN	NN	_	26	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	DNA	dna	NN	NN	_	31	compound	_	_
31	binding	binding	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	Mutation	mutation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	CBF1/RBP-Jkappa	cbf1/rbp-jkappa	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	EBNA3C	ebna3c	NN	NN	_	6	nmod	_	_
9	abrogated	abrogate	VBD	VBD	_	0	root	_	_
10	repression	repression	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	9	punct	_	_
12	strongly	strongly	RB	RB	_	13	advmod	_	_
13	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	CBF1/RBP-Jkappa	cbf1/rbp-jkappa	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	necessary	necessary	JJ	JJ	_	13	ccomp	_	_
18	for	for	IN	IN	_	19	mark	_	_
19	targeting	target	VBG	VBG	_	17	advcl	_	_
20	the	the	DT	DT	_	22	det	_	_
21	viral	viral	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	19	dobj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	Cp	cp	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Consistent	consistent	JJ	JJ	_	21	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	result	result	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	21	punct	_	_
6	mutation	mutation	NN	NN	_	21	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	EBNA2	ebna2	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	a	a	DT	DT	_	16	det	_	_
14	CBF1/RBP-Jkappa	cbf1/rbp-jkappa	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	Cp	cp	NN	NN	_	11	nmod	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	prevented	prevent	VBD	VBD	_	0	root	_	_
22	significant	significant	JJ	JJ	_	23	amod	_	_
23	repression	repression	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	27	nmod	_	_
3	,	,	,	,	_	27	punct	_	_
4	amino	amino	NN	NN	_	5	compound	_	_
5	acids	acid	NNS	NNS	_	27	nsubj	_	_
6	346	346	CD	CD	_	5	nummod	_	_
7	to	to	TO	TO	_	5	dep	_	_
8	543	543	CD	CD	_	5	nummod	_	_
9	,	,	,	,	_	5	punct	_	_
10	which	which	WDT	WDT	_	13	nsubjpass	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	previously	previously	RB	RB	_	13	advmod	_	_
13	defined	define	VBN	VBN	_	5	acl:relcl	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	important	important	JJ	JJ	_	13	advcl	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	repressor	repressor	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	GAL4-EBNA3C	gal4-ebna3c	NN	NN	_	24	compound	_	_
23	fusion	fusion	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	19	nmod	_	_
25	,	,	,	,	_	5	punct	_	_
26	also	also	RB	RB	_	27	advmod	_	_
27	appear	appear	VBP	VBP	_	0	root	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	be	be	VB	VB	_	30	cop	_	_
30	necessary	necessary	JJ	JJ	_	27	xcomp	_	_
31	for	for	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	repression	repression	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	Cp	cp	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	27	punct	_	_

1	Since	since	IN	IN	_	8	mark	_	_
2	repression	repression	NN	NN	_	8	nsubjpass	_	_
3	by	by	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	fusions	fusion	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	observed	observe	VBN	VBN	_	15	advcl	_	_
9	in	in	IN	IN	_	12	case	_	_
10	all	all	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	types	type	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	it	it	PRP	PRP	_	15	nsubj	_	_
15	seems	seem	VBZ	VBZ	_	0	root	_	_
16	likely	likely	RB	RB	_	15	xcomp	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	EBNA3C	ebna3c	NN	NN	_	20	nsubj	_	_
19	either	either	CC	CC	_	20	cc:preconj	_	_
20	depends	depend	VBZ	VBZ	_	15	ccomp	_	_
21	on	on	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	corepressor	corepressor	NN	NN	_	20	nmod	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	interact	interact	VB	VB	_	23	acl:relcl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	amino	amino	NN	NN	_	29	compound	_	_
29	acids	acid	NNS	NNS	_	26	nmod	_	_
30	346	346	CD	CD	_	29	nummod	_	_
31	to	to	TO	TO	_	29	dep	_	_
32	543	543	CD	CD	_	29	nummod	_	_
33	or	or	CC	CC	_	20	cc	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	modified	modify	VBN	VBN	_	20	conj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	cell-specific	cell-specific	JJ	JJ	_	39	amod	_	_
39	manner	manner	NN	NN	_	35	nmod	_	_
40	in	in	IN	IN	_	43	mark	_	_
41	order	order	NN	NN	_	40	mwe	_	_
42	to	to	TO	TO	_	43	mark	_	_
43	repress	repress	VB	VB	_	35	advcl	_	_
44	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	EBNA3C	ebna3c	NN	NN	_	4	nmod	_	_
7	contributing	contribute	VBG	VBG	_	6	acl	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	EBNA	ebna	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	latently	latently	RB	RB	_	18	advmod	_	_
16	infected	infected	JJ	JJ	_	18	amod	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	through	through	IN	IN	_	20	case	_	_
20	CBF1/RBP-Jkappa	cbf1/rbp-jkappa	NN	NN	_	10	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	another	another	DT	DT	_	23	det	_	_
23	factor	factor	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	4	punct	_	_
25	but	but	CC	CC	_	4	cc	_	_
26	this	this	DT	DT	_	27	nsubj	_	_
27	need	need	VBP	VBP	_	4	conj	_	_
28	not	not	RB	RB	_	30	neg	_	_
29	directly	directly	RB	RB	_	30	advmod	_	_
30	involve	involve	VB	VB	_	27	ccomp	_	_
31	EBNA2	ebna2	NN	NN	_	30	dobj	_	_
32	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	although	although	IN	IN	_	7	mark	_	_
4	it	it	PRP	PRP	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	reported	report	VBN	VBN	_	20	dep	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	EBNA3C	ebna3c	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	upregulate	upregulate	VB	VB	_	7	ccomp	_	_
12	CD21	cd21	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	some	some	DT	DT	_	16	det	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	we	we	PRP	PRP	_	20	nsubj	_	_
19	were	be	VBD	VBD	_	20	cop	_	_
20	unable	unable	JJ	JJ	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	demonstrate	demonstrate	VB	VB	_	20	xcomp	_	_
23	any	any	DT	DT	_	24	det	_	_
24	effect	effect	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	EBNA3C	ebna3c	NN	NN	_	24	nmod	_	_
27	on	on	IN	IN	_	29	case	_	_
28	reporter	reporter	NN	NN	_	29	compound	_	_
29	plasmids	plasmid	NNS	NNS	_	24	nmod	_	_
30	which	which	WDT	WDT	_	31	nsubj	_	_
31	contain	contain	VBP	VBP	_	29	acl:relcl	_	_
32	the	the	DT	DT	_	34	det	_	_
33	CD21	cd21	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	31	dobj	_	_
35	.	.	.	.	_	20	punct	_	_

1	Late	late	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	14	nsubj	_	_
4	from	from	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	BcLF1	bclf1	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	BFRF3	bfrf3	NN	NN	_	7	conj	_	_
11	promoters	promoter	NNS	NNS	_	7	dep	_	_
12	does	do	VBZ	VBZ	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	require	require	VB	VB	_	0	root	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	cis	cis	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	Late	late	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	follows	follow	VBZ	VBZ	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	dependent	dependent	JJ	JJ	_	4	conj	_	_
8	upon	upon	IN	IN	_	10	case	_	_
9	lytic	lytic	JJ	JJ	_	10	amod	_	_
10	replication	replication	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	genome	genome	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	experimental	experimental	JJ	JJ	_	3	amod	_	_
3	evidence	evidence	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	lacking	lacking	JJ	JJ	_	12	advcl	_	_
6	,	,	,	,	_	12	punct	_	_
7	lytic	lytic	JJ	JJ	_	10	amod	_	_
8	viral	viral	JJ	JJ	_	10	amod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	believed	believe	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	remove	remove	VB	VB	_	12	xcomp	_	_
15	modifications	modification	NNS	NNS	_	14	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	factors	factor	NNS	NNS	_	15	conj	_	_
19	from	from	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	genome	genome	NN	NN	_	15	nmod	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	serve	serve	VBP	VBP	_	12	dep	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	repress	repress	VB	VB	_	23	xcomp	_	_
26	late	late	JJ	JJ	_	28	amod	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	25	dobj	_	_
29	during	during	IN	IN	_	30	case	_	_
30	latency	latency	NN	NN	_	25	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	35	det	_	_
33	early	early	JJ	JJ	_	35	amod	_	_
34	lytic	lytic	JJ	JJ	_	35	amod	_	_
35	cycle	cycle	NN	NN	_	30	conj	_	_
36	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	developed	develop	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	reporter	reporter	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	begin	begin	VB	VB	_	3	xcomp	_	_
9	characterizing	characterize	VBG	VBG	_	8	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	mechanisms	mechanism	NNS	NNS	_	9	dobj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	regulate	regulate	VBP	VBP	_	11	acl:relcl	_	_
14	late	late	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	Epstein-Barr	epstein-barr	JJ	JJ	_	19	amod	_	_
19	virus	virus	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	EBV	ebv	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	model	model	NN	NN	_	4	compound	_	_
4	system	system	NN	NN	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	activities	activity	NNS	NNS	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	late	late	JJ	JJ	_	11	amod	_	_
10	promoter-reporter	promoter-reporter	JJ	JJ	_	11	amod	_	_
11	fusions	fusion	NNS	NNS	_	7	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	measured	measure	VBN	VBN	_	0	root	_	_
14	following	follow	VBG	VBG	_	16	case	_	_
15	transient	transient	JJ	JJ	_	16	amod	_	_
16	transfection	transfection	NN	NN	_	13	nmod	_	_
17	into	into	IN	IN	_	20	case	_	_
18	tissue	tissue	NN	NN	_	20	compound	_	_
19	culture	culture	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	expressing	express	VBG	VBG	_	20	acl	_	_
22	EBV	ebv	NN	NN	_	21	dobj	_	_
23	during	during	IN	IN	_	25	case	_	_
24	different	different	JJ	JJ	_	25	amod	_	_
25	stages	stage	NNS	NNS	_	21	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	lytic	lytic	JJ	JJ	_	29	amod	_	_
29	cycle	cycle	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	system	system	NN	NN	_	4	nsubj	_	_
3	faithfully	faithfully	RB	RB	_	4	advmod	_	_
4	recapitulates	recapitulate	VBZ	VBZ	_	0	root	_	_
5	late	late	JJ	JJ	_	7	amod	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	patterns	pattern	NNS	NNS	_	4	dobj	_	_
8	from	from	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	endogenous	endogenous	JJ	JJ	_	11	amod	_	_
11	virus	virus	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	implicating	implicate	VBG	VBG	_	4	advcl	_	_
14	specific	specific	JJ	JJ	_	16	amod	_	_
15	cis-active	cis-active	JJ	JJ	_	16	amod	_	_
16	sequences	sequence	NNS	NNS	_	13	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	control	control	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	late	late	JJ	JJ	_	23	amod	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	promoters	promoter	NNS	NNS	_	6	nsubj	_	_
6	respond	respond	VBP	VBP	_	0	root	_	_
7	only	only	RB	RB	_	8	advmod	_	_
8	indirectly	indirectly	RB	RB	_	6	advmod	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	viral	viral	JJ	JJ	_	13	amod	_	_
12	immediate-early	immediate-early	JJ	JJ	_	13	amod	_	_
13	transactivator	transactivator	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	ZEBRA	zebra	NN	NN	_	13	appos	_	_
16	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	indirect	indirect	JJ	JJ	_	3	amod	_	_
3	response	response	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	mediated	mediate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	other	other	JJ	JJ	_	8	amod	_	_
8	viral	viral	JJ	JJ	_	5	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	virally	virally	RB	RB	_	11	advmod	_	_
11	induced	induce	VBN	VBN	_	8	conj	_	_
12	activities	activity	NNS	NNS	_	8	dep	_	_
13	downstream	downstream	JJ	JJ	_	12	advmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	ZEBRA	zebra	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	lytic	lytic	JJ	JJ	_	19	amod	_	_
19	cascade	cascade	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	system	system	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	late	late	JJ	JJ	_	7	amod	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	sensitive	sensitive	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	inhibitors	inhibitor	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	viral	viral	JJ	JJ	_	16	amod	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	polymerase	polymerase	NN	NN	_	11	nmod	_	_
17	such	such	JJ	JJ	_	20	case	_	_
18	as	as	IN	IN	_	17	mwe	_	_
19	phosphonoacetic	phosphonoacetic	JJ	JJ	_	20	amod	_	_
20	acid	acid	NN	NN	_	11	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	although	although	IN	IN	_	25	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	reporters	reporter	NNS	NNS	_	25	nsubj	_	_
25	lack	lack	VBP	VBP	_	9	advcl	_	_
26	a	a	DT	DT	_	28	det	_	_
27	eukaryotic	eukaryotic	JJ	JJ	_	28	amod	_	_
28	origin	origin	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	replication	replication	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	are	be	VBP	VBP	_	34	auxpass	_	_
33	not	not	RB	RB	_	34	neg	_	_
34	replicated	replicate	VBN	VBN	_	25	conj	_	_
35	under	under	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	assay	assay	NN	NN	_	38	compound	_	_
38	conditions	condition	NNS	NNS	_	34	nmod	_	_
39	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	replication	replication	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	template	template	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	a	a	DT	DT	_	11	det	_	_
11	prerequisite	prerequisite	NN	NN	_	0	root	_	_
12	for	for	IN	IN	_	13	case	_	_
13	expression	expression	NN	NN	_	11	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	late	late	JJ	JJ	_	16	amod	_	_
16	kinetics	kinetics	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	a	a	DT	DT	_	19	det	_	_
19	finding	finding	NN	NN	_	11	dep	_	_
20	inconsistent	inconsistent	JJ	JJ	_	19	amod	_	_
21	with	with	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	current	current	JJ	JJ	_	24	amod	_	_
24	models	model	NNS	NNS	_	20	nmod	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	posit	posit	VBP	VBP	_	24	acl:relcl	_	_
27	a	a	DT	DT	_	29	det	_	_
28	cis-active	cis-active	JJ	JJ	_	29	amod	_	_
29	relationship	relationship	NN	NN	_	26	dobj	_	_
30	between	between	IN	IN	_	34	case	_	_
31	lytic	lytic	JJ	JJ	_	34	amod	_	_
32	EBV	ebv	NN	NN	_	34	compound	_	_
33	DNA	dna	NN	NN	_	34	compound	_	_
34	replication	replication	NN	NN	_	29	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	late	late	JJ	JJ	_	38	amod	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	34	conj	_	_
39	.	.	.	.	_	11	punct	_	_

1	Rather	rather	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	analysis	analysis	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	system	system	NN	NN	_	3	nmod	_	_
7	has	have	VBZ	VBZ	_	8	aux	_	_
8	revealed	reveal	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	trans	trans	JJ	JJ	_	11	amod	_	_
11	relationship	relationship	NN	NN	_	8	dobj	_	_
12	between	between	IN	IN	_	15	case	_	_
13	late	late	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	viral	viral	JJ	JJ	_	19	amod	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	replication	replication	NN	NN	_	15	conj	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	highlights	highlight	VBZ	VBZ	_	8	conj	_	_
22	the	the	DT	DT	_	26	det	_	_
23	indirect	indirect	JJ	JJ	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	complex	complex	JJ	JJ	_	23	conj	_	_
26	link	link	NN	NN	_	21	dobj	_	_
27	between	between	IN	IN	_	30	case	_	_
28	these	these	DT	DT	_	30	det	_	_
29	two	two	CD	CD	_	30	nummod	_	_
30	events	event	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	Purification	purification	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	SR	sr	NN	NN	_	9	compound	_	_
8	31747A-binding	31747a-binding	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	membrane	membrane	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	0	root	_	_
5	related	related	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	yeast	yeast	NN	NN	_	9	compound	_	_
8	sterol	sterol	NN	NN	_	9	compound	_	_
9	isomerase	isomerase	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	SR	sr	NN	NN	_	2	compound	_	_
2	31747A	31747a	NN	NN	_	14	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	defined	define	VBN	VBN	_	2	acl	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	sigma	sigma	NN	NN	_	8	compound	_	_
8	ligand	ligand	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	novel	novel	JJ	JJ	_	14	amod	_	_
13	immunosuppressive	immunosuppressive	JJ	JJ	_	12	dep	_	_
14	agent	agent	NN	NN	_	0	root	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	blocks	block	VBZ	VBZ	_	14	acl:relcl	_	_
17	proliferation	proliferation	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	human	human	JJ	JJ	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	mouse	mouse	NN	NN	_	19	conj	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	14	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	5	det	_	_
3	radiolabeled	radiolabeled	JJ	JJ	_	5	amod	_	_
4	chemical	chemical	JJ	JJ	_	3	dep	_	_
5	probe	probe	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	here	here	RB	RB	_	9	advmod	_	_
9	purified	purify	VBD	VBD	_	1	parataxis	_	_
10	a	a	DT	DT	_	11	det	_	_
11	target	target	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	SR	sr	NN	NN	_	14	compound	_	_
14	31747A	31747a	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	called	call	VBD	VBD	_	9	conj	_	_
17	it	it	PRP	PRP	_	20	nsubj	_	_
18	SR	sr	NN	NN	_	20	compound	_	_
19	31747A-binding	31747a-binding	JJ	JJ	_	20	amod	_	_
20	protein	protein	NN	NN	_	16	xcomp	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	SR-BP	sr-bp	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	1	punct	_	_

1	Purified	purify	VBN	VBN	_	2	amod	_	_
2	SR-BP	sr-bp	NN	NN	_	3	nsubj	_	_
3	retained	retain	VBD	VBD	_	0	root	_	_
4	its	its	PRP$	PRP$	_	6	nmod:poss	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	properties	property	NNS	NNS	_	3	dobj	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	migrated	migrate	VBD	VBD	_	3	conj	_	_
9	on	on	IN	IN	_	11	case	_	_
10	SDS-polyacrylamide	sds-polyacrylamide	JJ	JJ	_	11	amod	_	_
11	gel	gel	NN	NN	_	8	nmod	_	_
12	as	as	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	Mr	mr	NN	NN	_	16	compound	_	_
15	28,000	28,000	CD	CD	_	16	nummod	_	_
16	protein	protein	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Cloning	cloning	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cDNA	cdna	NN	NN	_	1	nmod	_	_
5	encoding	encode	VBG	VBG	_	4	acl	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	SR-BP	sr-bp	NN	NN	_	5	dobj	_	_
8	shows	show	VBZ	VBZ	_	0	root	_	_
9	an	a	DT	DT	_	12	det	_	_
10	open	open	JJ	JJ	_	12	amod	_	_
11	reading	reading	NN	NN	_	12	compound	_	_
12	frame	frame	NN	NN	_	8	dobj	_	_
13	for	for	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	223-amino	223-amino	NN	NN	_	17	compound	_	_
16	acid	acid	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	homologous	homologous	JJ	JJ	_	17	acl:relcl	_	_
22	to	to	TO	TO	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	recently	recently	RB	RB	_	25	advmod	_	_
25	cloned	clone	VBN	VBN	_	28	amod	_	_
26	sigma	sigma	NN	NN	_	28	compound	_	_
27	1	1	CD	CD	_	28	nummod	_	_
28	receptor	receptor	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	deduced	deduce	VBN	VBN	_	7	amod	_	_
5	amino	amino	NN	NN	_	7	compound	_	_
6	acid	acid	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	related	related	JJ	JJ	_	9	xcomp	_	_
13	to	to	TO	TO	_	17	case	_	_
14	fungal	fungal	JJ	JJ	_	17	amod	_	_
15	C8-C7	c8-c7	NN	NN	_	17	compound	_	_
16	sterol	sterol	NN	NN	_	17	compound	_	_
17	isomerase	isomerase	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	encoded	encode	VBN	VBN	_	17	acl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	ERG2	erg2	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	ERG2	erg2	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	recently	recently	RB	RB	_	7	advmod	_	_
9	as	as	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	molecular	molecular	JJ	JJ	_	12	amod	_	_
12	target	target	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	SR	sr	NN	NN	_	15	compound	_	_
15	31747A	31747a	NN	NN	_	12	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	mediates	mediate	VBZ	VBZ	_	15	acl:relcl	_	_
18	antiproliferative	antiproliferative	JJ	JJ	_	19	amod	_	_
19	effects	effect	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	drug	drug	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	yeast	yeast	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	SR-BP	sr-bp	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	single	single	JJ	JJ	_	11	amod	_	_
11	transcript	transcript	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	2	2	CD	CD	_	14	nummod	_	_
14	kilobases	kilobase	NNS	NNS	_	11	nmod	_	_
15	which	which	WDT	WDT	_	18	nsubjpass	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	widely	widely	RB	RB	_	18	advmod	_	_
18	expressed	express	VBN	VBN	_	11	acl:relcl	_	_
19	among	among	IN	IN	_	20	case	_	_
20	organs	organ	NNS	NNS	_	18	nmod	_	_
21	,	,	,	,	_	18	punct	_	_
22	with	with	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	highest	highest	JJS	JJS	_	25	amod	_	_
25	abundance	abundance	NN	NN	_	18	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	liver	liver	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	25	cc	_	_
29	the	the	DT	DT	_	31	det	_	_
30	lowest	lowest	JJS	JJS	_	31	amod	_	_
31	abundance	abundance	NN	NN	_	25	conj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	brain	brain	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Subcellular	subcellular	JJ	JJ	_	3	amod	_	_
2	localization	localization	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	17	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	various	various	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	using	use	VBG	VBG	_	3	acl	_	_
9	a	a	DT	DT	_	12	det	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	monoclonal	monoclonal	JJ	JJ	_	12	amod	_	_
12	antibody	antibody	NN	NN	_	8	dobj	_	_
13	raised	raise	VBN	VBN	_	12	acl	_	_
14	against	against	IN	IN	_	15	case	_	_
15	SR-BP	sr-bp	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	this	this	DT	DT	_	20	det	_	_
20	protein	protein	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	associated	associate	VBN	VBN	_	17	ccomp	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
26	envelope	envelope	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	studying	study	VBG	VBG	_	16	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	binding	binding	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	SR	sr	NN	NN	_	7	compound	_	_
7	31747A	31747a	NN	NN	_	4	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	membranes	membrane	NNS	NNS	_	7	nmod	_	_
10	from	from	IN	IN	_	11	case	_	_
11	yeast	yeast	NN	NN	_	9	nmod	_	_
12	expressing	express	VBG	VBG	_	11	acl	_	_
13	SR-BP	sr-bp	NN	NN	_	12	dobj	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	found	find	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	pharmacological	pharmacological	JJ	JJ	_	19	amod	_	_
19	profile	profile	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	sigma	sigma	NN	NN	_	23	compound	_	_
22	1	1	CD	CD	_	23	nummod	_	_
23	receptors	receptor	NNS	NNS	_	19	nmod	_	_
24	;	;	:	:	_	16	punct	_	_
25	binding	binding	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	displaced	displace	VBN	VBN	_	16	parataxis	_	_
28	by	by	IN	IN	_	29	case	_	_
29	(+)-pentazocine	(+)-pentazocine	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	haloperidol	haloperidol	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	(+)-SKF	(+)-skf	NN	NN	_	29	conj	_	_
35	10,047	10,047	CD	CD	_	34	nummod	_	_
36	,	,	,	,	_	27	punct	_	_
37	with	with	IN	IN	_	44	mark	_	_
38	(+)-SKF	(+)-skf	NN	NN	_	44	nsubj	_	_
39	10,047	10,047	CD	CD	_	38	nummod	_	_
40	being	be	VBG	VBG	_	44	cop	_	_
41	a	a	DT	DT	_	44	det	_	_
42	more	more	RBR	RBR	_	43	advmod	_	_
43	potent	potent	JJ	JJ	_	44	amod	_	_
44	competitor	competitor	NN	NN	_	27	advcl	_	_
45	than	than	IN	IN	_	46	case	_	_
46	(-)-SKF	(-)-skf	NN	NN	_	44	nmod	_	_
47	10,047	10,047	CD	CD	_	46	nummod	_	_
48	.	.	.	.	_	16	punct	_	_

1	Scatchard	scatchard	NN	NN	_	3	compound	_	_
2	plot	plot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	Kd	kd	NN	NN	_	6	compound	_	_
6	values	value	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	7.1	7.1	CD	CD	_	9	nummod	_	_
9	nM	nm	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	0.15	0.15	CD	CD	_	12	nummod	_	_
12	nM	nm	NN	NN	_	9	conj	_	_
13	for	for	IN	IN	_	14	case	_	_
14	(+)-pentazocine	(+)-pentazocine	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	SR	sr	NN	NN	_	17	compound	_	_
17	31747A	31747a	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	4	punct	_	_
19	respectively	respectively	RB	RB	_	4	advmod	_	_
20	,	,	,	,	_	4	punct	_	_
21	indicating	indicate	VBG	VBG	_	4	advcl	_	_
22	an	a	DT	DT	_	23	det	_	_
23	affinity	affinity	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	SR-BP	sr-bp	NN	NN	_	23	nmod	_	_
26	50-fold	50-fold	RB	RB	_	27	nmod:npmod	_	_
27	higher	higher	JJR	JJR	_	23	amod	_	_
28	for	for	IN	IN	_	30	case	_	_
29	SR	sr	NN	NN	_	30	compound	_	_
30	31747A	31747a	NN	NN	_	27	nmod	_	_
31	than	than	IN	IN	_	33	case	_	_
32	for	for	IN	IN	_	33	case	_	_
33	pentazocine	pentazocine	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	pentazocine	pentazocine	NN	NN	_	17	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	10	det	_	_
9	competitive	competitive	JJ	JJ	_	10	amod	_	_
10	inhibitor	inhibitor	NN	NN	_	6	appos	_	_
11	of	of	IN	IN	_	14	case	_	_
12	SR	sr	NN	NN	_	14	compound	_	_
13	31747A	31747a	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	prevents	prevent	VBZ	VBZ	_	4	ccomp	_	_
18	the	the	DT	DT	_	20	det	_	_
19	immunosuppressive	immunosuppressive	JJ	JJ	_	20	amod	_	_
20	effect	effect	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	SR	sr	NN	NN	_	23	compound	_	_
23	31747A	31747a	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	7	nsubj	_	_
6	strongly	strongly	RB	RB	_	7	advmod	_	_
7	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	SR-BP	sr-bp	NN	NN	_	10	nsubj	_	_
10	represents	represent	VBZ	VBZ	_	7	ccomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	target	target	NN	NN	_	10	dobj	_	_
14	for	for	IN	IN	_	16	case	_	_
15	SR	sr	NN	NN	_	16	compound	_	_
16	31747A	31747a	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	mammalian	mammalian	JJ	JJ	_	19	amod	_	_
19	tissues	tissue	NNS	NNS	_	10	nmod	_	_
20	,	,	,	,	_	7	punct	_	_
21	which	which	WDT	WDT	_	24	nsubj	_	_
22	could	could	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	critical	critical	JJ	JJ	_	7	dep	_	_
25	for	for	IN	IN	_	28	case	_	_
26	T	t	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	proliferation	proliferation	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	tax	tax	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	T-cell	t-cell	NN	NN	_	9	compound	_	_
7	leukemia	leukemia	NN	NN	_	9	compound	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	type	type	NN	NN	_	3	nmod	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	mediates	mediate	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	transactivation	transactivation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	c-sis/platelet-derived	c-sis/platelet-derived	JJ	JJ	_	19	amod	_	_
17	growth	growth	NN	NN	_	19	compound	_	_
18	factor-B	factor-b	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	13	nmod	_	_
20	through	through	IN	IN	_	21	case	_	_
21	interactions	interaction	NNS	NNS	_	11	nmod	_	_
22	with	with	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	zinc	zinc	NN	NN	_	27	compound	_	_
25	finger	finger	NN	NN	_	27	compound	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	21	nmod	_	_
28	Sp1	sp1	NN	NN	_	27	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	NGFI-A/Egr-1	ngfi-a/egr-1	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	11	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	up-regulation	up-regulation	NN	NN	_	25	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	c-sis/platelet-derived	c-sis/platelet-derived	JJ	JJ	_	11	amod	_	_
6	growth	growth	NN	NN	_	11	compound	_	_
7	factor-B	factor-b	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	PDGF-B	pdgf-b	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	proto-oncogene	proto-oncogene	NN	NN	_	2	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	Tax	tax	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	2	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	human	human	JJ	JJ	_	21	amod	_	_
18	T-cell	t-cell	NN	NN	_	21	compound	_	_
19	leukemia	leukemia	NN	NN	_	21	compound	_	_
20	virus	virus	NN	NN	_	21	compound	_	_
21	type	type	NN	NN	_	15	nmod	_	_
22	1	1	CD	CD	_	21	nummod	_	_
23	has	have	VBZ	VBZ	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	implicated	implicate	VBN	VBN	_	0	root	_	_
26	as	as	IN	IN	_	29	case	_	_
27	one	one	CD	CD	_	29	nummod	_	_
28	possible	possible	JJ	JJ	_	29	amod	_	_
29	mechanism	mechanism	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	cellular	cellular	JJ	JJ	_	32	amod	_	_
32	transformation	transformation	NN	NN	_	29	nmod	_	_
33	by	by	IN	IN	_	38	case	_	_
34	human	human	JJ	JJ	_	38	amod	_	_
35	T-cell	t-cell	NN	NN	_	38	compound	_	_
36	leukemia	leukemia	NN	NN	_	38	compound	_	_
37	virus	virus	NN	NN	_	38	compound	_	_
38	type	type	NN	NN	_	32	nmod	_	_
39	1	1	CD	CD	_	38	nummod	_	_
40	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	essential	essential	JJ	JJ	_	9	amod	_	_
9	site	site	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	c-sis/PDGF-B	c-sis/pdgf-b	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	Tax-responsive	tax-responsive	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	9	appos	_	_
17	1	1	CD	CD	_	16	nummod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TRE1	tre1	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	9	punct	_	_
22	necessary	necessary	JJ	JJ	_	9	amod	_	_
23	for	for	IN	IN	_	24	case	_	_
24	transactivation	transactivation	NN	NN	_	22	nmod	_	_
25	by	by	IN	IN	_	26	case	_	_
26	Tax	tax	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	Sp1	sp1	NN	NN	_	3	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	Sp3	sp3	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	NGFI-A/Egr-1	ngfi-a/egr-1	NN	NN	_	4	conj	_	_
10	as	as	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	primary	primary	JJ	JJ	_	15	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	3	nmod	_	_
16	binding	bind	VBG	VBG	_	15	acl	_	_
17	to	to	TO	TO	_	18	case	_	_
18	TRE1	tre1	NN	NN	_	16	nmod	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	mediate	mediate	VBP	VBP	_	15	acl:relcl	_	_
21	Tax	tax	NN	NN	_	22	compound	_	_
22	responsiveness	responsiveness	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	work	work	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	investigated	investigate	VBN	VBN	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	mechanism	mechanism	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	s	s	NNS	NNS	_	8	dobj	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	whereby	whereby	WRB	WRB	_	16	advmod	_	_
15	Tax	tax	NN	NN	_	16	nsubj	_	_
16	transactivates	transactivate	VBZ	VBZ	_	12	acl:relcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	c-sis/PDGF-B	c-sis/pdgf-b	NN	NN	_	19	compound	_	_
19	proto-oncogene	proto-oncogene	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	8	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	Tax	tax	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	able	able	JJ	JJ	_	5	ccomp	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	increase	increase	VB	VB	_	9	xcomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	template	template	NN	NN	_	15	nmod	_	_
19	containing	contain	VBG	VBG	_	18	acl	_	_
20	the	the	DT	DT	_	24	det	_	_
21	-257	-257	CD	CD	_	24	nummod	_	_
22	to	to	TO	TO	_	24	dep	_	_
23	+74	+74	CD	CD	_	24	nummod	_	_
24	region	region	NN	NN	_	19	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	c-sis/PDGF-B	c-sis/pdgf-b	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
2	mobility	mobility	NN	NN	_	5	compound	_	_
3	shift	shift	NN	NN	_	5	compound	_	_
4	assay	assay	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	6	nsubj	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	that	that	DT	DT	_	9	mark	_	_
8	Tax	tax	NN	NN	_	9	nsubj	_	_
9	increased	increase	VBD	VBD	_	6	ccomp	_	_
10	the	the	DT	DT	_	13	det	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	Sp1	sp1	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NGFI-A/Egr-1	ngfi-a/egr-1	NN	NN	_	16	conj	_	_
19	using	use	VBG	VBG	_	9	xcomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	TRE1	tre1	NN	NN	_	22	compound	_	_
22	probe	probe	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Analysis	analysis	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Tax	tax	NN	NN	_	4	compound	_	_
4	mutants	mutant	NNS	NNS	_	1	nmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	mutants	mutant	NNS	NNS	_	15	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	IEXC29S	iexc29s	NN	NN	_	8	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IEXL320G	iexl320g	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	unable	unable	JJ	JJ	_	5	ccomp	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	transactivate	transactivate	VB	VB	_	15	xcomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	c-sis/PDGF-B	c-sis/pdgf-b	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	co-immunoprecipitation	co-immunoprecipitation	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	Tax	tax	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	able	able	JJ	JJ	_	5	ccomp	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	stably	stably	RB	RB	_	12	advmod	_	_
12	bind	bind	VB	VB	_	9	xcomp	_	_
13	to	to	TO	TO	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	Sp1	sp1	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NGFI-A/Egr-1	ngfi-a/egr-1	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	Interestingly	interestingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	co-immunoprecipitation	co-immunoprecipitation	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	6	nsubj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	Tax	tax	NN	NN	_	9	compound	_	_
9	mutant	mutant	NN	NN	_	12	nsubj	_	_
10	IEXC29S	iexc29s	NN	NN	_	9	dep	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	unable	unable	JJ	JJ	_	6	ccomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	interact	interact	VB	VB	_	12	xcomp	_	_
15	with	with	IN	IN	_	16	case	_	_
16	NGFI-A/Egr-1	ngfi-a/egr-1	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	whereas	whereas	IN	IN	_	23	mark	_	_
19	Tax	tax	NN	NN	_	20	compound	_	_
20	mutant	mutant	NN	NN	_	23	nsubj	_	_
21	IEXL320G	iexl320g	NN	NN	_	20	dep	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	able	able	JJ	JJ	_	12	advcl	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	interact	interact	VB	VB	_	23	xcomp	_	_
26	with	with	IN	IN	_	27	case	_	_
27	NGFI-A/Egr-1	ngfi-a/egr-1	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Stable	stable	JJ	JJ	_	2	amod	_	_
2	transfection	transfection	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	U937	u937	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	sense	sense	NN	NN	_	2	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	antisense	antisense	JJ	JJ	_	11	amod	_	_
10	RXR-alpha	rxr-alpha	NN	NN	_	11	compound	_	_
11	cDNA	cdna	NN	NN	_	7	conj	_	_
12	suggests	suggest	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	role	role	NN	NN	_	12	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	RXR-alpha	rxr-alpha	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	control	control	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	monoblastic	monoblastic	JJ	JJ	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	19	nmod	_	_
23	induced	induce	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	26	case	_	_
25	retinoic	retinoic	JJ	JJ	_	26	amod	_	_
26	acid	acid	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	vitamin	vitamin	NN	NN	_	29	compound	_	_
29	D	d	NN	NN	_	26	conj	_	_
30	.	.	.	.	_	12	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	retinoic	retinoic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	RA	ra	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	known	know	VBN	VBN	_	38	advcl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	many	many	JJ	JJ	_	12	amod	_	_
12	years	year	NNS	NNS	_	17	nmod	_	_
13	to	to	TO	TO	_	17	mark	_	_
14	be	be	VB	VB	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	modulating	modulate	VBG	VBG	_	17	amod	_	_
17	agent	agent	NN	NN	_	9	xcomp	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	plays	play	VBZ	VBZ	_	17	acl:relcl	_	_
20	a	a	DT	DT	_	21	det	_	_
21	role	role	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	23	mark	_	_
23	generating	generate	VBG	VBG	_	19	advcl	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	granulocytes	granulocyte	NNS	NNS	_	23	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	monocytes	monocyte	NNS	NNS	_	25	conj	_	_
28	,	,	,	,	_	38	punct	_	_
29	the	the	DT	DT	_	31	det	_	_
30	molecular	molecular	JJ	JJ	_	31	amod	_	_
31	mechanism	mechanism	NN	NN	_	38	nsubjpass	_	_
32	underlying	underlie	VBG	VBG	_	31	acl	_	_
33	this	this	DT	DT	_	34	det	_	_
34	role	role	NN	NN	_	32	dobj	_	_
35	has	have	VBZ	VBZ	_	38	aux	_	_
36	not	not	RB	RB	_	38	neg	_	_
37	been	be	VBN	VBN	_	38	auxpass	_	_
38	defined	define	VBN	VBN	_	0	root	_	_
39	in	in	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	monoblast	monoblast	NN	NN	_	42	compound	_	_
42	lineage	lineage	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	38	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	30	nmod	_	_
3	,	,	,	,	_	30	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	part	part	NN	NN	_	30	nsubjpass	_	_
6	played	play	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	retinoid	retinoid	JJ	JJ	_	11	amod	_	_
10	X	x	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	RXRs	rxr	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	members	member	NNS	NNS	_	11	acl:relcl	_	_
19	of	of	IN	IN	_	25	case	_	_
20	the	the	DT	DT	_	25	det	_	_
21	steroid/thyroid	steroid/thyroid	NN	NN	_	25	compound	_	_
22	hormone	hormone	NN	NN	_	25	compound	_	_
23	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	family	family	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	5	punct	_	_
27	has	have	VBZ	VBZ	_	30	aux	_	_
28	not	not	RB	RB	_	30	neg	_	_
29	been	be	VBN	VBN	_	30	auxpass	_	_
30	explored	explore	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	therefore	therefore	RB	RB	_	16	advmod	_	_
6	,	,	,	,	_	16	punct	_	_
7	the	the	DT	DT	_	13	det	_	_
8	human	human	JJ	JJ	_	13	amod	_	_
9	monoblastic	monoblastic	JJ	JJ	_	13	amod	_	_
10	leukemia	leukemia	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	line	line	NN	NN	_	13	compound	_	_
13	U937	u937	NN	NN	_	16	nsubjpass	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	used	use	VBN	VBN	_	0	root	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	model	model	NN	NN	_	20	compound	_	_
20	system	system	NN	NN	_	16	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	investigate	investigate	VB	VB	_	20	acl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	role	role	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	one	one	CD	CD	_	24	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	RXRs	rxr	NNS	NNS	_	26	nmod	_	_
30	,	,	,	,	_	26	punct	_	_
31	RXR-alpha	rxr-alpha	NN	NN	_	26	appos	_	_
32	,	,	,	,	_	24	punct	_	_
33	in	in	IN	IN	_	35	case	_	_
34	monoblast	monoblast	NN	NN	_	35	compound	_	_
35	differentiation	differentiation	NN	NN	_	24	nmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	RXR-alpha	rxr-alpha	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	present	present	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	untreated	untreated	JJ	JJ	_	8	amod	_	_
7	U937	u937	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	levels	level	NNS	NNS	_	12	nsubj	_	_
12	increased	increase	VBD	VBD	_	4	conj	_	_
13	after	after	IN	IN	_	14	case	_	_
14	induction	induction	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	differentiation	differentiation	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	phorbol	phorbol	NN	NN	_	19	compound	_	_
19	ester	ester	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	same	same	JJ	JJ	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	RXR-beta	rxr-beta	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	plasmids	plasmid	NNS	NNS	_	1	dobj	_	_
3	containing	contain	VBG	VBG	_	2	acl	_	_
4	sense	sense	NN	NN	_	3	dobj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	antisense	antisense	JJ	JJ	_	8	amod	_	_
7	RXR-alpha	rxr-alpha	NN	NN	_	8	compound	_	_
8	sequences	sequence	NNS	NNS	_	4	conj	_	_
9	under	under	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	control	control	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	inducible	inducible	JJ	JJ	_	15	amod	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	1	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	generated	generate	VBD	VBD	_	1	parataxis	_	_
19	stably	stably	RB	RB	_	20	advmod	_	_
20	transfected	transfect	VBN	VBN	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	dobj	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	expressed	express	VBD	VBD	_	22	acl:relcl	_	_
25	either	either	CC	CC	_	26	cc:preconj	_	_
26	increased	increase	VBN	VBN	_	24	dobj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	decreased	decrease	VBN	VBN	_	26	conj	_	_
29	levels	level	NNS	NNS	_	26	dep	_	_
30	of	of	IN	IN	_	31	case	_	_
31	RXR-alpha	rxr-alpha	NN	NN	_	29	nmod	_	_
32	,	,	,	,	_	24	punct	_	_
33	respectively	respectively	RB	RB	_	24	advmod	_	_
34	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	sense	sense	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	16	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	U	u	NN	NN	_	8	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	S	s	NN	NN	_	4	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	clonal	clonal	JJ	JJ	_	12	amod	_	_
12	derivative	derivative	JJ	JJ	_	8	conj	_	_
13	alpha	alpha	NN	NN	_	12	dep	_	_
14	G2S	g2s	NN	NN	_	13	dep	_	_
15	)	)	-RRB-	-RRB-	_	8	punct	_	_
16	showed	show	VBD	VBD	_	0	root	_	_
17	increased	increase	VBN	VBN	_	18	amod	_	_
18	sensitivity	sensitivity	NN	NN	_	16	dobj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	RA	ra	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	while	while	IN	IN	_	38	mark	_	_
23	the	the	DT	DT	_	26	det	_	_
24	antisense	antisense	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	38	nsubj	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	U	u	NN	NN	_	30	compound	_	_
29	alpha	alpha	NN	NN	_	30	compound	_	_
30	A	a	NN	NN	_	26	dep	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
33	clonal	clonal	JJ	JJ	_	34	amod	_	_
34	derivative	derivative	JJ	JJ	_	30	conj	_	_
35	alpha	alpha	NN	NN	_	34	dep	_	_
36	B5A	b5a	NN	NN	_	35	dep	_	_
37	)	)	-RRB-	-RRB-	_	30	punct	_	_
38	showed	show	VBD	VBD	_	16	advcl	_	_
39	decreased	decrease	VBN	VBN	_	40	amod	_	_
40	sensitivity	sensitivity	NN	NN	_	38	dobj	_	_
41	to	to	TO	TO	_	42	case	_	_
42	RA	ra	NN	NN	_	40	nmod	_	_
43	,	,	,	,	_	16	punct	_	_
44	as	as	IN	IN	_	45	dep	_	_
45	demonstrated	demonstrate	VBN	VBN	_	16	advcl	_	_
46	by	by	IN	IN	_	48	case	_	_
47	growth	growth	NN	NN	_	48	compound	_	_
48	inhibition	inhibition	NN	NN	_	45	nmod	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	by	by	IN	IN	_	51	case	_	_
51	regulation	regulation	NN	NN	_	48	conj	_	_
52	of	of	IN	IN	_	56	case	_	_
53	an	a	DT	DT	_	56	det	_	_
54	RA-responsive	ra-responsive	JJ	JJ	_	56	amod	_	_
55	reporter	reporter	NN	NN	_	56	compound	_	_
56	gene	gene	NN	NN	_	51	nmod	_	_
57	.	.	.	.	_	16	punct	_	_

1	Both	both	CC	CC	_	4	cc:preconj	_	_
2	U	u	NN	NN	_	4	compound	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	9	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	alpha	alpha	NN	NN	_	4	conj	_	_
7	B5A	b5a	NN	NN	_	6	dep	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	failed	fail	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	respond	respond	VB	VB	_	9	xcomp	_	_
12	to	to	TO	TO	_	15	case	_	_
13	another	another	DT	DT	_	15	det	_	_
14	modulating	modulate	VBG	VBG	_	15	amod	_	_
15	agent	agent	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	1	1	CD	CD	_	18	nummod	_	_
18	alpha,25-dihydroxycholecalciferol	alpha,25-dihydroxycholecalciferol	NN	NN	_	15	appos	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	DHCC	dhcc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	9	punct	_	_
23	but	but	CC	CC	_	9	cc	_	_
24	only	only	RB	RB	_	27	advmod	_	_
25	U	u	NN	NN	_	27	compound	_	_
26	alpha	alpha	NN	NN	_	27	compound	_	_
27	S	s	NN	NN	_	32	nsubj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	not	not	RB	RB	_	31	neg	_	_
30	alpha	alpha	NN	NN	_	31	compound	_	_
31	G2S	g2s	NN	NN	_	27	conj	_	_
32	showed	show	VBD	VBD	_	9	conj	_	_
33	an	a	DT	DT	_	35	det	_	_
34	enhanced	enhance	VBN	VBN	_	35	amod	_	_
35	response	response	NN	NN	_	32	dobj	_	_
36	to	to	TO	TO	_	37	case	_	_
37	DHCC	dhcc	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	combination	combination	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	RA	ra	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	DHCC	dhcc	NN	NN	_	4	conj	_	_
7	together	together	RB	RB	_	8	advmod	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	growth	growth	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	sense	sense	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	antisense	antisense	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	alpha	alpha	NN	NN	_	5	compound	_	_
5	G2S	g2s	NN	NN	_	6	nsubj	_	_
6	exhibited	exhibit	VBD	VBD	_	0	root	_	_
7	increased	increase	VBN	VBN	_	8	amod	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CD11b	cd11b	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CD54	cd54	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	while	while	IN	IN	_	18	mark	_	_
15	alpha	alpha	NN	NN	_	17	compound	_	_
16	B5A	b5a	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	18	nsubj	_	_
18	showed	show	VBD	VBD	_	6	advcl	_	_
19	increased	increase	VBN	VBN	_	20	amod	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	CD102	cd102	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
25	that	that	IN	IN	_	27	mark	_	_
26	RXR-alpha	rxr-alpha	NN	NN	_	27	nsubj	_	_
27	has	have	VBZ	VBZ	_	24	ccomp	_	_
28	a	a	DT	DT	_	29	det	_	_
29	role	role	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	31	mark	_	_
31	regulating	regulate	VBG	VBG	_	27	advcl	_	_
32	expression	expression	NN	NN	_	31	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	adhesion	adhesion	NN	NN	_	36	compound	_	_
36	molecules	molecule	NNS	NNS	_	32	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	U937	u937	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	31	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	RXR-alpha	rxr-alpha	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	mediating	mediate	VBG	VBG	_	6	advcl	_	_
11	growth	growth	NN	NN	_	12	compound	_	_
12	inhibition	inhibition	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	adhesion	adhesion	NN	NN	_	12	conj	_	_
16	during	during	IN	IN	_	18	case	_	_
17	myelomonocytic	myelomonocytic	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	10	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	and	and	CC	CC	_	3	cc	_	_
21	suggest	suggest	VBP	VBP	_	3	conj	_	_
22	that	that	IN	IN	_	30	mark	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	species	species	NNS	NNS	_	30	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	heterodimers	heterodimer	NNS	NNS	_	24	nmod	_	_
27	involving	involve	VBG	VBG	_	24	acl	_	_
28	RXR-alpha	rxr-alpha	NN	NN	_	27	dobj	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	control	control	VB	VB	_	21	ccomp	_	_
31	the	the	DT	DT	_	32	det	_	_
32	acquisition	acquisition	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	different	different	JJ	JJ	_	35	amod	_	_
35	features	feature	NNS	NNS	_	32	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	mature	mature	JJ	JJ	_	39	amod	_	_
38	monocyte/macrophage	monocyte/macrophage	NN	NN	_	39	compound	_	_
39	function	function	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	B-lymphoblastoid	b-lymphoblastoid	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	0	root	_	_
4	from	from	IN	IN	_	7	case	_	_
5	multiple	multiple	JJ	JJ	_	7	amod	_	_
6	sclerosis	sclerosis	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	a	a	DT	DT	_	11	det	_	_
10	healthy	healthy	JJ	JJ	_	11	amod	_	_
11	control	control	NN	NN	_	7	conj	_	_
12	producing	produce	VBG	VBG	_	3	acl	_	_
13	a	a	DT	DT	_	17	det	_	_
14	putative	putative	JJ	JJ	_	15	amod	_	_
15	new	new	JJ	JJ	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	retrovirus	retrovirus	NN	NN	_	12	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	Epstein-Barr	epstein-barr	JJ	JJ	_	20	amod	_	_
20	virus	virus	NN	NN	_	17	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	several	several	JJ	JJ	_	3	amod	_	_
3	occasions	occasion	NNS	NNS	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	retrovirus-like	retrovirus-like	JJ	JJ	_	8	amod	_	_
8	particles	particle	NNS	NNS	_	6	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	RVLPs	rvlp	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	by	by	IN	IN	_	15	case	_	_
13	transmission	transmission	NN	NN	_	15	compound	_	_
14	electron	electron	NN	NN	_	15	compound	_	_
15	microscopy	microscopy	NN	NN	_	6	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	EM	em	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	of	of	IN	IN	_	22	case	_	_
20	cultured	culture	VBN	VBN	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	from	from	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	patient	patient	NN	NN	_	22	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	MS	ms	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Later	later	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	established	establish	VBD	VBD	_	0	root	_	_
4	spontaneously	spontaneously	RB	RB	_	5	advmod	_	_
5	formed	form	VBN	VBN	_	8	amod	_	_
6	B-lymphoblastoid	b-lymphoblastoid	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	3	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LCLs	lcl	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	from	from	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	patient	patient	NN	NN	_	3	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	MS-like	ms-like	JJ	JJ	_	18	amod	_	_
18	disease	disease	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	from	from	IN	IN	_	22	case	_	_
21	another	another	DT	DT	_	22	det	_	_
22	patient	patient	NN	NN	_	14	conj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	MS	ms	NN	NN	_	22	nmod	_	_
25	who	who	WP	WP	_	26	nsubj	_	_
26	had	have	VBD	VBD	_	22	acl:relcl	_	_
27	a	a	DT	DT	_	34	det	_	_
28	reactivated	reactivate	VBN	VBN	_	34	amod	_	_
29	Epstein-Barr	epstein-barr	JJ	JJ	_	30	amod	_	_
30	virus	virus	NN	NN	_	34	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	EBV	ebv	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	infection	infection	NN	NN	_	26	dobj	_	_
35	.	.	.	.	_	3	punct	_	_

1	Both	both	DT	DT	_	2	dep	_	_
2	LCLs	lcl	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	EM	em	NN	NN	_	8	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	produce	produce	VB	VB	_	4	xcomp	_	_
9	RVLP	rvlp	NN	NN	_	8	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	EBV	ebv	NN	NN	_	12	compound	_	_
12	particles	particle	NNS	NNS	_	9	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	Reverse	reverse	JJ	JJ	_	2	amod	_	_
2	transcriptase	transcriptase	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RT	rt	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	assays	assay	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	positive	positive	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	purified	purify	VBN	VBN	_	12	amod	_	_
11	viral	viral	JJ	JJ	_	12	amod	_	_
12	material	material	NN	NN	_	8	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	both	both	DT	DT	_	15	dep	_	_
15	LCLs	lcl	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	substantiate	substantiate	VB	VB	_	0	root	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	2	dobj	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	initiated	initiate	VBD	VBD	_	2	parataxis	_	_
7	an	a	DT	DT	_	10	det	_	_
8	intensified	intensify	VBN	VBN	_	10	amod	_	_
9	culturing	culturing	NN	NN	_	10	compound	_	_
10	procedure	procedure	NN	NN	_	6	dobj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	able	able	JJ	JJ	_	6	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	establish	establish	VB	VB	_	13	xcomp	_	_
16	LCLs	lcl	NNS	NNS	_	15	dobj	_	_
17	from	from	IN	IN	_	24	case	_	_
18	5	5	CD	CD	_	21	compound	_	_
19	out	out	RB	RB	_	21	advmod	_	_
20	of	of	IN	IN	_	21	advmod	_	_
21	21	21	CD	CD	_	24	nummod	_	_
22	consecutive	consecutive	JJ	JJ	_	24	amod	_	_
23	MS	ms	NN	NN	_	24	compound	_	_
24	patients	patient	NNS	NNS	_	15	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	1	1	CD	CD	_	29	compound	_	_
27	out	out	RB	RB	_	29	advmod	_	_
28	of	of	IN	IN	_	29	advmod	_	_
29	13	13	CD	CD	_	32	nummod	_	_
30	consecutive	consecutive	JJ	JJ	_	31	amod	_	_
31	healthy	healthy	JJ	JJ	_	32	amod	_	_
32	controls	control	NNS	NNS	_	24	conj	_	_
33	.	.	.	.	_	2	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	LCLs	lcl	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	produce	produce	VB	VB	_	4	xcomp	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	RVLP	rvlp	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	EBV	ebv	NN	NN	_	11	compound	_	_
11	particles	particle	NNS	NNS	_	8	conj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	EM	em	NN	NN	_	4	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Whether	whether	IN	IN	_	11	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	putative	putative	JJ	JJ	_	4	amod	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	retrovirus	retrovirus	NN	NN	_	11	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	es	e	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	EBV	ebv	NN	NN	_	5	conj	_	_
11	have	have	VBP	VBP	_	20	csubjpass	_	_
12	any	any	DT	DT	_	14	det	_	_
13	causal	causal	JJ	JJ	_	14	amod	_	_
14	relationship	relationship	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	MS	ms	NN	NN	_	14	nmod	_	_
17	is	be	VBZ	VBZ	_	20	auxpass	_	_
18	still	still	RB	RB	_	20	advmod	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	known	know	VBN	VBN	_	0	root	_	_
21	,	,	,	,	_	20	punct	_	_
22	but	but	CC	CC	_	20	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	findings	finding	NNS	NNS	_	25	nsubj	_	_
25	support	support	VBP	VBP	_	20	conj	_	_
26	this	this	DT	DT	_	27	det	_	_
27	possibility	possibility	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	20	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	different	different	JJ	JJ	_	5	amod	_	_
4	transduction	transduction	NN	NN	_	5	compound	_	_
5	pathways	pathway	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	several	several	JJ	JJ	_	12	amod	_	_
12	inducers	inducer	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Double-stimulation	double-stimulation	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	demonstrate	demonstrate	VB	VB	_	3	xcomp	_	_
6	that	that	IN	IN	_	25	mark	_	_
7	,	,	,	,	_	25	punct	_	_
8	in	in	IN	IN	_	13	case	_	_
9	a	a	DT	DT	_	13	det	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	lymphocytic	lymphocytic	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	25	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CEM	cem	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	25	punct	_	_
18	phorbol	phorbol	NN	NN	_	20	compound	_	_
19	myristate	myristate	NN	NN	_	20	compound	_	_
20	acetate	acetate	NN	NN	_	25	nsubj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	PMA	pma	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	rapidly	rapidly	RB	RB	_	25	advmod	_	_
25	induced	induce	VBD	VBD	_	5	ccomp	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	25	dobj	_	_
28	through	through	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	signaling	signaling	NN	NN	_	31	compound	_	_
31	pathway	pathway	NN	NN	_	25	nmod	_	_
32	which	which	WDT	WDT	_	35	nsubj	_	_
33	did	do	VBD	VBD	_	35	aux	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	involve	involve	VB	VB	_	25	dep	_	_
36	reactive	reactive	JJ	JJ	_	38	amod	_	_
37	oxygen	oxygen	NN	NN	_	38	compound	_	_
38	species	species	NNS	NNS	_	35	dobj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	ROS	ro	NNS	NNS	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	and	and	CC	CC	_	35	cc	_	_
43	was	be	VBD	VBD	_	44	cop	_	_
44	different	different	JJ	JJ	_	35	conj	_	_
45	from	from	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	activation	activation	NN	NN	_	44	nmod	_	_
48	triggered	trigger	VBN	VBN	_	47	acl	_	_
49	by	by	IN	IN	_	51	case	_	_
50	either	either	CC	CC	_	51	cc:preconj	_	_
51	H2O2	h2o2	NN	NN	_	48	nmod	_	_
52	or	or	CC	CC	_	51	cc	_	_
53	tumor	tumor	NN	NN	_	55	compound	_	_
54	necrosis	necrosis	NN	NN	_	55	compound	_	_
55	factor-alpha	factor-alpha	NN	NN	_	51	conj	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	TNF-alpha	tnf-alpha	NN	NN	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	these	these	DT	DT	_	4	det	_	_
3	latter	latter	JJ	JJ	_	4	amod	_	_
4	compounds	compound	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	19	advcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	activate	activate	VB	VB	_	6	xcomp	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	translocation	translocation	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	redox-sensitive	redox-sensitive	JJ	JJ	_	15	amod	_	_
15	way	way	NN	NN	_	8	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
20	that	that	IN	IN	_	27	mark	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	27	nsubj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	PMA	pma	NN	NN	_	23	nmod	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	resistant	resistant	JJ	JJ	_	19	ccomp	_	_
28	to	to	TO	TO	_	29	case	_	_
29	antioxidant	antioxidant	JJ	JJ	_	27	nmod	_	_
30	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	29	dep	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	NAC	nac	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	27	cc	_	_
35	sensitive	sensitive	JJ	JJ	_	27	conj	_	_
36	to	to	TO	TO	_	38	case	_	_
37	kinase	kinase	NN	NN	_	38	compound	_	_
38	inhibitors	inhibitor	NNS	NNS	_	35	nmod	_	_
39	staurosporine	staurosporine	NN	NN	_	38	dep	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	H7	h7	NN	NN	_	39	conj	_	_
42	while	while	IN	IN	_	48	mark	_	_
43	activation	activation	NN	NN	_	48	nsubj	_	_
44	by	by	IN	IN	_	45	case	_	_
45	H2O2	h2o2	NN	NN	_	43	nmod	_	_
46	or	or	CC	CC	_	45	cc	_	_
47	TNF-alpha	tnf-alpha	NN	NN	_	45	conj	_	_
48	were	be	VBD	VBD	_	27	advcl	_	_
49	not	not	RB	RB	_	48	neg	_	_
50	.	.	.	.	_	19	punct	_	_

1	Association	association	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	insensitivity	insensitivity	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	increased	increase	VBN	VBN	_	7	amod	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	beta	beta	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	many	many	JJ	JJ	_	5	amod	_	_
3	chronic	chronic	JJ	JJ	_	5	amod	_	_
4	inflammatory	inflammatory	JJ	JJ	_	5	amod	_	_
5	disorders	disorder	NNS	NNS	_	16	nmod	_	_
6	,	,	,	,	_	16	punct	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	GC	gc	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	insensitivity	insensitivity	NN	NN	_	16	nsubj	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	a	a	DT	DT	_	16	det	_	_
14	challenging	challenging	JJ	JJ	_	16	amod	_	_
15	clinical	clinical	JJ	JJ	_	14	dep	_	_
16	problem	problem	NN	NN	_	0	root	_	_
17	associated	associate	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	21	case	_	_
19	life-threatening	life-threatening	JJ	JJ	_	21	amod	_	_
20	disease	disease	NN	NN	_	21	compound	_	_
21	progression	progression	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	GC	gc	NN	NN	_	6	compound	_	_
6	insensitivity	insensitivity	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	however	however	RB	RB	_	11	advmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	unknown	unknown	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Alternative	alternative	JJ	JJ	_	2	amod	_	_
2	splicing	splicing	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	GC	gc	NN	NN	_	11	compound	_	_
6	receptor	receptor	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	11	punct	_	_
8	R	r	NN	NN	_	11	compound	_	_
9	)	)	-RRB-	-RRB-	_	11	punct	_	_
10	pre-messenger	pre-messenger	NN	NN	_	11	compound	_	_
11	RNA	rna	NN	NN	_	2	nmod	_	_
12	generates	generate	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	second	second	JJ	JJ	_	15	amod	_	_
15	GCR	gcr	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	termed	term	VBN	VBN	_	15	acl	_	_
18	GCR-beta	gcr-beta	NN	NN	_	17	xcomp	_	_
19	,	,	,	,	_	15	punct	_	_
20	which	which	WDT	WDT	_	23	nsubj	_	_
21	does	do	VBZ	VBZ	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	bind	bind	VB	VB	_	15	acl:relcl	_	_
24	GCs	gc	NNS	NNS	_	23	dobj	_	_
25	but	but	CC	CC	_	23	cc	_	_
26	antagonizes	antagonize	VBZ	VBZ	_	23	conj	_	_
27	the	the	DT	DT	_	29	det	_	_
28	transactivating	transactivating	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	26	dobj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	classic	classic	JJ	JJ	_	33	amod	_	_
33	GCR	gcr	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	termed	term	VBN	VBN	_	33	acl	_	_
36	GCR-alpha	gcr-alpha	NN	NN	_	35	xcomp	_	_
37	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	GC-insensitive	gc-insensitive	JJ	JJ	_	10	amod	_	_
10	asthma	asthma	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	7	ccomp	_	_
13	with	with	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	higher	higher	JJR	JJR	_	17	amod	_	_
17	number	number	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	GCR-beta-immunoreactive	gcr-beta-immunoreactive	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
23	blood	blood	NN	NN	_	20	nmod	_	_
24	than	than	IN	IN	_	26	mark	_	_
25	GC-sensitive	gc-sensitive	JJ	JJ	_	26	amod	_	_
26	asthmatics	asthmatic	NNS	NNS	_	17	dep	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	normal	normal	JJ	JJ	_	29	amod	_	_
29	controls	control	NNS	NNS	_	26	conj	_	_
30	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	patients	patient	NNS	NNS	_	10	nsubj	_	_
7	with	with	IN	IN	_	9	case	_	_
8	GC-insensitive	gc-insensitive	JJ	JJ	_	9	amod	_	_
9	asthma	asthma	NN	NN	_	6	nmod	_	_
10	have	have	VBP	VBP	_	4	ccomp	_	_
11	cytokine-induced	cytokine-induced	JJ	JJ	_	12	amod	_	_
12	abnormalities	abnormality	NNS	NNS	_	10	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	capability	capability	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	GCR	gcr	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	abnormalities	abnormality	NNS	NNS	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	reproduced	reproduce	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	transfection	transfection	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	7	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GCR-beta	gcr-beta	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	7	nmod	_	_
15	resulting	result	VBG	VBG	_	5	xcomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	significant	significant	JJ	JJ	_	18	amod	_	_
18	reduction	reduction	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	24	case	_	_
20	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
21	GCR-alpha	gcr-alpha	NN	NN	_	24	compound	_	_
22	DNA	dna	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	capacity	capacity	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	expression	expression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GCR-beta	gcr-beta	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	cytokine	cytokine	NN	NN	_	10	nmod:npmod	_	_
10	inducible	inducible	JJ	JJ	_	2	ccomp	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	account	account	VB	VB	_	10	conj	_	_
14	for	for	IN	IN	_	16	case	_	_
15	GC	gc	NN	NN	_	16	compound	_	_
16	insensitivity	insensitivity	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	this	this	DT	DT	_	21	det	_	_
19	common	common	JJ	JJ	_	21	amod	_	_
20	inflammatory	inflammatory	JJ	JJ	_	19	dep	_	_
21	condition	condition	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cell	cell	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	promotion	promotion	NN	NN	_	1	conj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	natural	natural	JJ	JJ	_	11	amod	_	_
9	killer	killer	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	development	development	NN	NN	_	6	nmod	_	_
12	by	by	IN	IN	_	19	case	_	_
13	the	the	DT	DT	_	19	det	_	_
14	dominant	dominant	JJ	JJ	_	19	amod	_	_
15	negative	negative	JJ	JJ	_	19	amod	_	_
16	helix	helix	NN	NN	_	19	compound	_	_
17	loop	loop	NN	NN	_	19	compound	_	_
18	helix	helix	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	1	nmod	_	_
20	Id3	id3	NN	NN	_	19	dep	_	_
21	.	.	.	.	_	1	punct	_	_

1	Bipotential	bipotential	JJ	JJ	_	8	amod	_	_
2	T/natural	t/natural	JJ	JJ	_	8	amod	_	_
3	killer	killer	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	NK	nk	NN	NN	_	8	compound	_	_
6	)	)	-RRB-	-RRB-	_	8	punct	_	_
7	progenitor	progenitor	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	10	nsubj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	present	present	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	thymus	thymus	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
3	bipotential	bipotential	JJ	JJ	_	4	amod	_	_
4	capacity	capacity	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	these	these	DT	DT	_	7	det	_	_
7	progenitors	progenitor	NNS	NNS	_	8	nsubj	_	_
8	develop	develop	VBP	VBP	_	0	root	_	_
9	predominantly	predominantly	RB	RB	_	12	advmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	thymus	thymus	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	8	nsubj	_	_
3	controlling	control	VBG	VBG	_	2	acl	_	_
4	this	this	DT	DT	_	6	det	_	_
5	developmental	developmental	JJ	JJ	_	6	amod	_	_
6	choice	choice	NN	NN	_	3	dobj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	unknown	unknown	JJ	JJ	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	present	present	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	24	mark	_	_
6	a	a	DT	DT	_	9	det	_	_
7	member	member	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	s	s	NNS	NNS	_	24	nsubj	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	family	family	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	23	case	_	_
15	basic	basic	JJ	JJ	_	23	amod	_	_
16	helix	helix	NN	NN	_	23	compound	_	_
17	loop	loop	NN	NN	_	23	compound	_	_
18	helix	helix	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	bHLH	bhlh	JJ	JJ	_	23	amod	_	_
21	)	)	-RRB-	-RRB-	_	23	punct	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	13	nmod	_	_
24	determines	determine	VBZ	VBZ	_	4	ccomp	_	_
25	lineage	lineage	NN	NN	_	26	compound	_	_
26	specification	specification	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	NK/T	nk/t	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	progenitors	progenitor	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	natural	natural	JJ	JJ	_	6	amod	_	_
3	dominant	dominant	JJ	JJ	_	6	amod	_	_
4	negative	negative	JJ	JJ	_	6	amod	_	_
5	HLH	hlh	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	22	nsubjpass	_	_
7	Id3	id3	NN	NN	_	6	dep	_	_
8	,	,	,	,	_	6	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	blocks	block	VBZ	VBZ	_	6	acl:relcl	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	number	number	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	known	known	JJ	JJ	_	19	amod	_	_
18	bHLH	bhlh	JJ	JJ	_	19	amod	_	_
19	factors	factor	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	26	case	_	_
24	CD34+	cd34+	JJ	JJ	_	26	amod	_	_
25	progenitor	progenitor	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	by	by	IN	IN	_	30	case	_	_
28	retrovirus-mediated	retrovirus-mediated	JJ	JJ	_	30	amod	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	transfer	transfer	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	22	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Id3	id3	NN	NN	_	2	nmod	_	_
5	completely	completely	RB	RB	_	6	advmod	_	_
6	blocks	block	VBZ	VBZ	_	0	root	_	_
7	development	development	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CD34+	cd34+	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	into	into	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	in	in	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	fetal	fetal	JJ	JJ	_	19	amod	_	_
17	thymic	thymic	JJ	JJ	_	19	amod	_	_
18	organ	organ	NN	NN	_	19	compound	_	_
19	culture	culture	NN	NN	_	7	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	FTOC	ftoc	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	development	development	NN	NN	_	12	nsubjpass	_	_
5	into	into	IN	IN	_	7	case	_	_
6	NK	nk	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	FTOC	ftoc	NN	NN	_	4	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	enhanced	enhance	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activity	activity	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	bHLH	bhlh	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	necessary	necessary	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	lineage	lineage	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	bipotential	bipotential	JJ	JJ	_	18	amod	_	_
18	precursors	precursor	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	absence	absence	NN	NN	_	34	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	22	nmod	_	_
25	a	a	DT	DT	_	27	det	_	_
26	default	default	NN	NN	_	27	compound	_	_
27	pathway	pathway	NN	NN	_	34	nsubjpass	_	_
28	leading	lead	VBG	VBG	_	27	acl	_	_
29	to	to	TO	TO	_	32	case	_	_
30	NK	nk	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	development	development	NN	NN	_	28	nmod	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	chosen	choose	VBN	VBN	_	18	acl:relcl	_	_
35	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	switch	switch	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	lineage	lineage	NN	NN	_	9	compound	_	_
9	specification	specification	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	early	early	JJ	JJ	_	13	amod	_	_
12	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
13	precursors	precursor	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	humans	human	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	MHC	mhc	NN	NN	_	4	compound	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	4	nummod	_	_
6	expression	expression	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	class	class	NN	NN	_	12	compound	_	_
10	II	ii	CD	CD	_	12	nummod	_	_
11	trans-activator	trans-activator	NN	NN	_	12	compound	_	_
12	constructs	construct	NNS	NNS	_	1	nmod	_	_
13	lacking	lack	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	N-terminal	n-terminal	JJ	JJ	_	16	amod	_	_
16	domain	domain	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	trans-activator	trans-activator	NN	NN	_	14	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CIITA	ciita	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	14	cop	_	_
9	a	a	DT	DT	_	14	det	_	_
10	bi-	bi-	RB	RB	_	14	compound	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	multi-functional	multi-functional	JJ	JJ	_	10	conj	_	_
13	domain	domain	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	0	root	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	plays	play	VBZ	VBZ	_	14	acl:relcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	critical	critical	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	MHC	mhc	NN	NN	_	27	compound	_	_
25	class	class	NN	NN	_	27	compound	_	_
26	II	ii	CD	CD	_	27	nummod	_	_
27	genes	gene	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	DT	DT	_	25	mark	_	_
4	removal	removal	NN	NN	_	25	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	N-terminal	n-terminal	JJ	JJ	_	10	amod	_	_
8	151	151	CD	CD	_	10	nummod	_	_
9	amino	amino	NN	NN	_	10	compound	_	_
10	acids	acid	NNS	NNS	_	4	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	encompassing	encompass	VBG	VBG	_	4	dep	_	_
13	all	all	DT	DT	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	acidic	acidic	JJ	JJ	_	17	amod	_	_
17	domain	domain	NN	NN	_	13	nmod	_	_
18	but	but	CC	CC	_	12	cc	_	_
19	leaving	leave	VBG	VBG	_	12	conj	_	_
20	intact	intact	JJ	JJ	_	19	dep	_	_
21	the	the	DT	DT	_	23	det	_	_
22	proline/serine/threonine-rich	proline/serine/threonine-rich	JJ	JJ	_	23	amod	_	_
23	domain	domain	NN	NN	_	20	dep	_	_
24	,	,	,	,	_	4	punct	_	_
25	results	result	VBZ	VBZ	_	2	ccomp	_	_
26	in	in	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	mutant	mutant	JJ	JJ	_	29	amod	_	_
29	protein	protein	NN	NN	_	25	nmod	_	_
30	with	with	IN	IN	_	33	case	_	_
31	potent	potent	JJ	JJ	_	33	amod	_	_
32	suppressive	suppressive	JJ	JJ	_	31	dep	_	_
33	properties	property	NNS	NNS	_	29	nmod	_	_
34	for	for	IN	IN	_	38	case	_	_
35	MHC	mhc	NN	NN	_	36	compound	_	_
36	class	class	NN	NN	_	38	compound	_	_
37	II	ii	CD	CD	_	36	nummod	_	_
38	expression	expression	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	HeLa	hela	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	11	nsubj	_	_
3	stably	stably	RB	RB	_	4	advmod	_	_
4	or	or	CC	CC	_	6	advmod	_	_
5	transiently	transiently	RB	RB	_	4	advmod	_	_
6	transfected	transfect	VBN	VBN	_	2	acl	_	_
7	with	with	IN	IN	_	10	case	_	_
8	mutant	mutant	JJ	JJ	_	10	amod	_	_
9	CIITA	ciita	NN	NN	_	10	compound	_	_
10	constructs	construct	NNS	NNS	_	6	nmod	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	up	up	RB	RB	_	14	advmod	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	99	99	CD	CD	_	15	dep	_	_
15	%	%	NN	NN	_	16	dep	_	_
16	suppression	suppression	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	MHC	mhc	NN	NN	_	19	compound	_	_
19	class	class	NN	NN	_	22	compound	_	_
20	II	ii	CD	CD	_	19	nummod	_	_
21	antigen	antigen	NN	NN	_	22	compound	_	_
22	induction	induction	NN	NN	_	16	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	IFN-gamma	ifn-gamma	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	marked	marked	JJ	JJ	_	27	amod	_	_
27	suppression	suppression	NN	NN	_	16	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	HLA-DRA	hla-dra	NN	NN	_	30	compound	_	_
30	mRNA	mrna	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	transfection	transfection	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	B	b	NN	NN	_	7	compound	_	_
6	lymphoma	lymphoma	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	2	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	14	case	_	_
10	up	up	RB	RB	_	12	advmod	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	89	89	CD	CD	_	13	dep	_	_
13	%	%	NN	NN	_	14	dep	_	_
14	reduction	reduction	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
17	MHC	mhc	NN	NN	_	18	compound	_	_
18	class	class	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	18	nummod	_	_
20	expression	expression	NN	NN	_	14	nmod	_	_
21	within	within	IN	IN	_	23	case	_	_
22	5	5	CD	CD	_	23	nummod	_	_
23	days	day	NNS	NNS	_	14	nmod	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	suppression	suppression	NN	NN	_	14	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	HLA-DRA	hla-dra	NN	NN	_	28	compound	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	synthesis	synthesis	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	proliferation	proliferation	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	apoptosis	apoptosis	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	human	human	JJ	JJ	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	rat	rat	NN	NN	_	7	conj	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	7	dep	_	_
12	by	by	IN	IN	_	13	case	_	_
13	curcumin	curcumin	NN	NN	_	1	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	curry	curry	NN	NN	_	17	compound	_	_
17	pigment	pigment	NN	NN	_	13	appos	_	_
18	.	.	.	.	_	1	punct	_	_

1	Curcumin	curcumin	NN	NN	_	26	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	diferuoylmethane	diferuoylmethane	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	yellow	yellow	JJ	JJ	_	8	amod	_	_
8	pigment	pigment	NN	NN	_	1	appos	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	rhizome	rhizome	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	tumeric	tumeric	JJ	JJ	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	Curcuma	curcuma	FW	FW	_	16	compound	_	_
16	longa	longa	FW	FW	_	13	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	1	punct	_	_
19	an	a	DT	DT	_	20	det	_	_
20	ingredient	ingredient	NN	NN	_	1	appos	_	_
21	of	of	IN	IN	_	23	case	_	_
22	curry	curry	NN	NN	_	23	compound	_	_
23	spice	spice	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	1	punct	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	known	know	VBN	VBN	_	0	root	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	exhibit	exhibit	VB	VB	_	26	xcomp	_	_
29	a	a	DT	DT	_	30	det	_	_
30	variety	variety	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	pharmacological	pharmacological	JJ	JJ	_	33	amod	_	_
33	effects	effect	NNS	NNS	_	30	nmod	_	_
34	including	include	VBG	VBG	_	35	case	_	_
35	antitumor	antitumor	JJ	JJ	_	30	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	antiinflammatory	antiinflammatory	JJ	JJ	_	35	conj	_	_
38	,	,	,	,	_	35	punct	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	antiinfectious	antiinfectious	JJ	JJ	_	35	conj	_	_
41	activities	activity	NNS	NNS	_	35	dep	_	_
42	.	.	.	.	_	26	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
3	precise	precise	JJ	JJ	_	4	amod	_	_
4	mode	mode	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	action	action	NN	NN	_	4	nmod	_	_
7	remains	remain	VBZ	VBZ	_	13	advcl	_	_
8	elusive	elusive	JJ	JJ	_	7	xcomp	_	_
9	,	,	,	,	_	13	punct	_	_
10	curcumin	curcumin	NN	NN	_	13	nsubjpass	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	shown	show	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	suppress	suppress	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activity	activity	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	AP-1	ap-1	NN	NN	_	17	nmod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	20	dep	_	_
23	in	in	IN	IN	_	24	case	_	_
24	cells	cell	NNS	NNS	_	17	nmod	_	_
25	stimulated	stimulate	VBN	VBN	_	24	acl	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	proliferate	proliferate	VB	VB	_	25	xcomp	_	_
28	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	observed	observe	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	curcumin	curcumin	NN	NN	_	13	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	50	50	CD	CD	_	11	nummod	_	_
11	microM	microm	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	inhibited	inhibit	VBD	VBD	_	6	ccomp	_	_
14	proliferation	proliferation	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	rat	rat	NN	NN	_	17	compound	_	_
17	thymocytes	thymocyte	NNS	NNS	_	14	nmod	_	_
18	stimulated	stimulate	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	21	case	_	_
20	concanavalin	concanavalin	NN	NN	_	21	compound	_	_
21	A	a	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	Con	con	NN	NN	_	24	compound	_	_
24	A	a	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	as	as	RB	RB	_	14	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	that	that	DT	DT	_	14	conj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	human	human	JJ	JJ	_	34	amod	_	_
32	Jurkat	jurkat	NN	NN	_	34	compound	_	_
33	lymphoblastoid	lymphoblastoid	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	in	in	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	logarithmic	logarithmic	JJ	JJ	_	39	amod	_	_
38	growth	growth	NN	NN	_	39	compound	_	_
39	phase	phase	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pigment	pigment	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	apoptosis	apoptosis	NN	NN	_	4	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	dexamethasone-treated	dexamethasone-treated	JJ	JJ	_	9	amod	_	_
8	rat	rat	NN	NN	_	9	compound	_	_
9	thymocytes	thymocyte	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	in	in	IN	IN	_	14	case	_	_
12	UV-irradiated	uv-irradiated	JJ	JJ	_	14	amod	_	_
13	Jurkat	jurkat	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	conj	_	_
15	as	as	IN	IN	_	16	mark	_	_
16	judged	judge	VBN	VBN	_	4	advcl	_	_
17	by	by	IN	IN	_	20	case	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	ladder	ladder	NN	NN	_	20	compound	_	_
20	formation	formation	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	cellular	cellular	JJ	JJ	_	24	amod	_	_
23	morphological	morphological	JJ	JJ	_	24	amod	_	_
24	changes	change	NNS	NNS	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	flow	flow	NN	NN	_	28	compound	_	_
28	cytometry	cytometry	NN	NN	_	20	conj	_	_
29	analysis	analysis	NN	NN	_	20	dep	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	curcumin	curcumin	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	rat	rat	NN	NN	_	9	compound	_	_
9	thymocytes	thymocyte	NNS	NNS	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	accompanied	accompany	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	partial	partial	JJ	JJ	_	14	amod	_	_
14	suppression	suppression	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	AP-1	ap-1	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Complete	complete	JJ	JJ	_	2	amod	_	_
2	suppression	suppression	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	AP-1	ap-1	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	Con	con	NN	NN	_	13	compound	_	_
10	A-treated	a-treated	NN	NN	_	13	compound	_	_
11	,	,	,	,	_	13	punct	_	_
12	proliferating	proliferate	VBG	VBG	_	13	amod	_	_
13	thymocytes	thymocyte	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	capacity	capacity	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	curcumin	curcumin	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	2	acl	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	cell	cell	NN	NN	_	6	dobj	_	_
9	growth	growth	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	death	death	NN	NN	_	8	conj	_	_
12	strongly	strongly	RB	RB	_	13	advmod	_	_
13	implies	imply	VBZ	VBZ	_	0	root	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	these	these	DT	DT	_	18	det	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	biological	biological	JJ	JJ	_	18	amod	_	_
18	processes	process	NNS	NNS	_	19	nsubj	_	_
19	share	share	VBP	VBP	_	13	ccomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	common	common	JJ	JJ	_	22	amod	_	_
22	pathway	pathway	NN	NN	_	19	dobj	_	_
23	at	at	IN	IN	_	25	case	_	_
24	some	some	DT	DT	_	25	det	_	_
25	point	point	NN	NN	_	19	nmod	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	that	that	IN	IN	_	29	mark	_	_
28	curcumin	curcumin	NN	NN	_	29	nsubj	_	_
29	affects	affect	VBZ	VBZ	_	19	conj	_	_
30	a	a	DT	DT	_	32	det	_	_
31	common	common	JJ	JJ	_	32	amod	_	_
32	step	step	NN	NN	_	29	dobj	_	_
33	,	,	,	,	_	32	punct	_	_
34	presumably	presumably	RB	RB	_	35	advmod	_	_
35	involving	involve	VBG	VBG	_	32	acl	_	_
36	a	a	DT	DT	_	37	det	_	_
37	modulation	modulation	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	AP-1	ap-1	NN	NN	_	37	nmod	_	_
41	transcription	transcription	NN	NN	_	42	compound	_	_
42	factor	factor	NN	NN	_	40	dep	_	_
43	.	.	.	.	_	13	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	localization	localization	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	RelB	relb	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	associated	associate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	effective	effective	JJ	JJ	_	11	amod	_	_
9	antigen-presenting	antigen-presenting	JJ	JJ	_	8	dep	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Dendritic	dendritic	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	DC	dc	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	potent	potent	JJ	JJ	_	8	amod	_	_
8	APCs	apc	NNS	NNS	_	0	root	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	enter	enter	VBP	VBP	_	8	acl:relcl	_	_
11	resting	rest	VBG	VBG	_	12	amod	_	_
12	tissues	tissue	NNS	NNS	_	10	dobj	_	_
13	as	as	IN	IN	_	14	case	_	_
14	precursors	precursor	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	,	,	,	,	_	10	punct	_	_
17	after	after	IN	IN	_	19	case	_	_
18	Ag	ag	NN	NN	_	19	compound	_	_
19	exposure	exposure	NN	NN	_	21	nmod	_	_
20	,	,	,	,	_	21	punct	_	_
21	differentiate	differentiate	VBP	VBP	_	10	conj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	migrate	migrate	VBP	VBP	_	21	conj	_	_
24	to	to	TO	TO	_	27	case	_	_
25	draining	drain	VBG	VBG	_	27	amod	_	_
26	lymph	lymph	NN	NN	_	27	compound	_	_
27	nodes	node	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	phenotype	phenotype	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	RelB	relb	NN	NN	_	6	compound	_	_
5	knockout	knockout	NN	NN	_	6	compound	_	_
6	mice	mouse	NNS	NNS	_	2	nmod	_	_
7	implicates	implicate	VBZ	VBZ	_	0	root	_	_
8	this	this	DT	DT	_	9	det	_	_
9	member	member	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	NF	nf	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B/Rel	b/rel	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	DC	dc	NNS	NNS	_	18	compound	_	_
18	differentiation	differentiation	NN	NN	_	7	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	elucidate	elucidate	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	RelB	relb	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	DC	dc	NNS	NNS	_	10	compound	_	_
10	differentiation	differentiation	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	mRNA	mrna	NN	NN	_	25	nsubjpass	_	_
13	,	,	,	,	_	12	punct	_	_
14	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	DNA	dna	NN	NN	_	21	compound	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	12	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	RelB	relb	NN	NN	_	21	nmod	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	examined	examine	VBN	VBN	_	3	parataxis	_	_
26	in	in	IN	IN	_	27	case	_	_
27	immature	immature	JJ	JJ	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	differentiated	differentiate	VBN	VBN	_	27	conj	_	_
30	human	human	JJ	JJ	_	31	amod	_	_
31	DC	dc	NNS	NNS	_	27	dep	_	_
32	,	,	,	,	_	27	punct	_	_
33	as	as	RB	RB	_	27	cc	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	as	as	IN	IN	_	33	mwe	_	_
36	other	other	JJ	JJ	_	40	amod	_	_
37	PB	pb	NN	NN	_	40	compound	_	_
38	mononuclear	mononuclear	JJ	JJ	_	40	amod	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	populations	population	NNS	NNS	_	27	conj	_	_
41	.	.	.	.	_	3	punct	_	_

1	RelB	relb	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	6	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mRNA	mrna	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	constitutively	constitutively	RB	RB	_	6	advmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	in	in	IN	IN	_	13	case	_	_
12	activated	activate	VBN	VBN	_	13	amod	_	_
13	monocytes	monocyte	NNS	NNS	_	9	conj	_	_
14	,	,	,	,	_	13	punct	_	_
15	differentiated	differentiate	VBN	VBN	_	16	amod	_	_
16	DC	dc	NNS	NNS	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	monocyte-derived	monocyte-derived	JJ	JJ	_	20	amod	_	_
20	DC	dc	NNS	NNS	_	13	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	Immunohistochemical	immunohistochemical	JJ	JJ	_	2	amod	_	_
2	staining	staining	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	RelB	relb	NN	NN	_	3	dobj	_	_
5	within	within	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	differentiated	differentiate	VBN	VBN	_	11	amod	_	_
8	lymph	lymph	NN	NN	_	11	compound	_	_
9	node	node	NN	NN	_	11	compound	_	_
10	interdigitating	interdigitating	NN	NN	_	11	compound	_	_
11	DC	dc	NNS	NNS	_	3	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	follicular	follicular	JJ	JJ	_	14	amod	_	_
14	DC	dc	NNS	NNS	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	11	cc	_	_
18	undifferentiated	undifferentiated	JJ	JJ	_	19	amod	_	_
19	DC	dc	NNS	NNS	_	11	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	normal	normal	JJ	JJ	_	22	amod	_	_
22	skin	skin	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Active	active	JJ	JJ	_	2	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	RelB	relb	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	supershift	supershift	NN	NN	_	8	compound	_	_
8	assay	assay	NN	NN	_	5	nmod	_	_
9	only	only	RB	RB	_	12	advmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	differentiated	differentiated	JJ	JJ	_	12	amod	_	_
12	DC	dc	NNS	NNS	_	5	nmod	_	_
13	derived	derive	VBN	VBN	_	12	acl	_	_
14	from	from	IN	IN	_	17	case	_	_
15	either	either	CC	CC	_	17	cc:preconj	_	_
16	PB	pb	NN	NN	_	17	compound	_	_
17	precursors	precursor	NNS	NNS	_	13	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	monocytes	monocyte	NNS	NNS	_	17	conj	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	in	in	IN	IN	_	24	case	_	_
22	activated	activate	VBN	VBN	_	24	amod	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	12	conj	_	_
25	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	RelB+	relb+	JJ	JJ	_	3	amod	_	_
3	APC	apc	NN	NN	_	6	nsubj	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	stimulators	stimulator	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	MLR	mlr	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	RelB	relb	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	transcriptionally	transcriptionally	RB	RB	_	11	advmod	_	_
11	and	and	CC	CC	_	8	advmod	_	_
12	post-translationally	post-translationally	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	nucleus	nucleus	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	RelB	relb	NN	NN	_	6	compound	_	_
6	may	may	NN	NN	_	8	nsubj	_	_
7	specifically	specifically	RB	RB	_	8	advmod	_	_
8	transactivate	transactivate	VB	VB	_	0	root	_	_
9	genes	gene	NNS	NNS	_	8	dobj	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	critical	critical	JJ	JJ	_	9	acl:relcl	_	_
13	for	for	IN	IN	_	15	case	_	_
14	APC	apc	NN	NN	_	15	compound	_	_
15	function	function	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
4	factor-kappa	factor-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	inhibitor	inhibitor	NN	NN	_	5	conj	_	_
9	I	i	NN	NN	_	11	compound	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B-alpha/MAD-3	b-alpha/mad-3	NN	NN	_	8	dep	_	_
12	in	in	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	Mycobacterium	mycobacterium	NN	NN	_	16	compound	_	_
16	tuberculosis	tuberculosis	NN	NN	_	1	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	during	during	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	tuberculosis	tuberculosis	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	Blood	blood	NN	NN	_	2	compound	_	_
2	monocytes	monocyte	NNS	NNS	_	9	nsubjpass	_	_
3	from	from	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	tuberculosis	tuberculosis	NN	NN	_	4	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	activated	activate	VBN	VBN	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	evidenced	evidence	VBN	VBN	_	9	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	an	a	DT	DT	_	17	det	_	_
17	increase	increase	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	stimulated	stimulate	VBN	VBN	_	21	amod	_	_
21	release	release	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	proinflammatory	proinflammatory	JJ	JJ	_	24	amod	_	_
24	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	such	such	JJ	JJ	_	28	case	_	_
27	as	as	IN	IN	_	26	mwe	_	_
28	TNF-alpha	tnf-alpha	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	17	punct	_	_
30	and	and	CC	CC	_	17	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	spontaneous	spontaneous	JJ	JJ	_	33	amod	_	_
33	expression	expression	NN	NN	_	17	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	IL-2R	il-2r	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	Further	further	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	monocytes	monocyte	NNS	NNS	_	6	nsubj	_	_
4	from	from	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	augmented	augmented	JJ	JJ	_	9	amod	_	_
9	susceptibility	susceptibility	NN	NN	_	6	dobj	_	_
10	to	to	TO	TO	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	productive	productive	JJ	JJ	_	13	amod	_	_
13	infection	infection	NN	NN	_	9	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	HIV-1	hiv-1	NN	NN	_	13	nmod	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vitro	vitro	FW	FW	_	6	advmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Mycobacterium	mycobacterium	NN	NN	_	2	compound	_	_
2	tuberculosis	tuberculosis	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
5	components	component	NNS	NNS	_	2	conj	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	strong	strong	JJ	JJ	_	8	amod	_	_
8	signals	signal	NNS	NNS	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	activate	activate	VB	VB	_	8	acl	_	_
11	monocytes	monocyte	NNS	NNS	_	10	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	production	production	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cytokines	cytokine	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	examined	examine	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	basis	basis	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	during	during	IN	IN	_	14	case	_	_
13	active	active	JJ	JJ	_	14	amod	_	_
14	tuberculosis	tuberculosis	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	by	by	IN	IN	_	18	case	_	_
17	M.	m.	NN	NN	_	18	compound	_	_
18	tuberculosis	tuberculosis	NN	NN	_	14	conj	_	_
19	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	constitutive	constitutive	JJ	JJ	_	5	amod	_	_
5	degradation	degradation	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	I	i	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B-alpha	b-alpha	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	the	the	DT	DT	_	14	det	_	_
12	major	major	JJ	JJ	_	14	amod	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	14	amod	_	_
14	inhibitor	inhibitor	NN	NN	_	9	appos	_	_
15	of	of	IN	IN	_	19	case	_	_
16	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	5	punct	_	_
25	in	in	IN	IN	_	28	case	_	_
26	freshly	freshly	RB	RB	_	27	advmod	_	_
27	isolated	isolate	VBN	VBN	_	28	amod	_	_
28	PBMC	pbmc	NN	NN	_	5	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	monocytes	monocyte	NNS	NNS	_	28	conj	_	_
31	from	from	IN	IN	_	32	case	_	_
32	patients	patient	NNS	NNS	_	28	nmod	_	_
33	with	with	IN	IN	_	34	case	_	_
34	tuberculosis	tuberculosis	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	I	i	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B-alpha	b-alpha	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	23	nsubj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	PBMC	pbmc	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	monocytes	monocyte	NNS	NNS	_	9	conj	_	_
12	from	from	IN	IN	_	14	case	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	subjects	subject	NNS	NNS	_	9	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	from	from	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	14	conj	_	_
18	with	with	IN	IN	_	21	case	_	_
19	nontuberculous	nontuberculous	JJ	JJ	_	20	amod	_	_
20	pulmonary	pulmonary	JJ	JJ	_	21	amod	_	_
21	conditions	condition	NNS	NNS	_	17	nmod	_	_
22	were	be	VBD	VBD	_	23	cop	_	_
23	intact	intact	JJ	JJ	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	Further	further	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	by	by	IN	IN	_	7	case	_	_
4	electrophoretic	electrophoretic	JJ	JJ	_	7	amod	_	_
5	mobility	mobility	NN	NN	_	7	compound	_	_
6	shift	shift	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	12	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	activated	activate	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	tuberculous	tuberculous	JJ	JJ	_	17	amod	_	_
17	patients	patient	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	I	i	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B-alpha	b-alpha	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	responsive	responsive	JJ	JJ	_	7	acl:relcl	_	_
12	to	to	TO	TO	_	13	case	_	_
13	activation	activation	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	21	case	_	_
21	PBMC	pbmc	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	monocytes	monocyte	NNS	NNS	_	21	conj	_	_
24	from	from	IN	IN	_	25	case	_	_
25	patients	patient	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	but	but	CC	CC	_	21	cc	_	_
28	not	not	RB	RB	_	31	neg	_	_
29	in	in	IN	IN	_	31	case	_	_
30	mononuclear	mononuclear	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	21	conj	_	_
32	from	from	IN	IN	_	34	case	_	_
33	healthy	healthy	JJ	JJ	_	34	amod	_	_
34	subjects	subject	NNS	NNS	_	31	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	those	those	DT	DT	_	34	conj	_	_
37	with	with	IN	IN	_	40	case	_	_
38	nontuberculous	nontuberculous	JJ	JJ	_	40	amod	_	_
39	lung	lung	NN	NN	_	40	compound	_	_
40	diseases	disease	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	19	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	21	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	other	other	JJ	JJ	_	10	amod	_	_
8	adherence-associated	adherence-associated	JJ	JJ	_	10	amod	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	such	such	JJ	JJ	_	14	case	_	_
13	as	as	IN	IN	_	12	mwe	_	_
14	IL-8	il-8	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-1	il-1	NN	NN	_	17	compound	_	_
17	beta	beta	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	5	punct	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
22	in	in	IN	IN	_	23	case	_	_
23	PBMC	pbmc	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	tuberculous	tuberculous	JJ	JJ	_	26	amod	_	_
26	patients	patient	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	21	punct	_	_

1	Further	further	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	M.	m.	NN	NN	_	4	compound	_	_
4	tuberculosis	tuberculosis	NN	NN	_	13	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
7	tuberculin	tuberculin	NN	NN	_	4	conj	_	_
8	,	,	,	,	_	7	punct	_	_
9	purified	purify	VBN	VBN	_	11	amod	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	derivative	derivative	NN	NN	_	7	appos	_	_
12	,	,	,	,	_	4	punct	_	_
13	induced	induce	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	degradation	degradation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	I	i	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B-alpha	b-alpha	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	15	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	I	i	NN	NN	_	27	compound	_	_
25	kappa	kappa	NN	NN	_	27	compound	_	_
26	B-alpha	b-alpha	NN	NN	_	27	compound	_	_
27	mRNA	mrna	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	13	punct	_	_
29	and	and	CC	CC	_	13	cc	_	_
30	purified	purify	VBN	VBN	_	32	amod	_	_
31	protein	protein	NN	NN	_	32	compound	_	_
32	derivative	derivative	NN	NN	_	33	nsubj	_	_
33	induced	induce	VBD	VBD	_	13	conj	_	_
34	the	the	DT	DT	_	35	det	_	_
35	activation	activation	NN	NN	_	33	dobj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	35	nmod	_	_
39	in	in	IN	IN	_	40	case	_	_
40	monocytes	monocyte	NNS	NNS	_	33	nmod	_	_
41	.	.	.	.	_	13	punct	_	_

1	Relationship	relationship	NN	NN	_	0	root	_	_
2	between	between	IN	IN	_	4	case	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	response	response	NN	NN	_	4	conj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	therapy	therapy	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	ulcerative	ulcerative	JJ	JJ	_	12	amod	_	_
12	colitis	colitis	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	PURPOSE	purpose	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	clarify	clarify	VB	VB	_	1	dep	_	_
5	the	the	DT	DT	_	6	det	_	_
6	relationship	relationship	NN	NN	_	4	dobj	_	_
7	between	between	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	effectiveness	effectiveness	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	therapy	therapy	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	patients	patient	NNS	NNS	_	16	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	ulcerative	ulcerative	JJ	JJ	_	21	amod	_	_
21	colitis	colitis	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	4	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	investigated	investigate	VBD	VBD	_	4	parataxis	_	_
25	the	the	DT	DT	_	26	dep	_	_
26	number	number	NN	NN	_	24	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	apparent	apparent	JJ	JJ	_	30	amod	_	_
29	dissociation	dissociation	NN	NN	_	30	compound	_	_
30	constant	constant	NN	NN	_	26	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	glucocorticoid	glucocorticoid	NN	NN	_	33	compound	_	_
33	receptor	receptor	NN	NN	_	26	nmod	_	_
34	in	in	IN	IN	_	38	case	_	_
35	peripheral	peripheral	JJ	JJ	_	38	amod	_	_
36	blood	blood	NN	NN	_	38	compound	_	_
37	mononuclear	mononuclear	JJ	JJ	_	38	amod	_	_
38	leukocytes	leukocyte	NNS	NNS	_	33	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	patients	patient	NNS	NNS	_	38	nmod	_	_
41	with	with	IN	IN	_	43	case	_	_
42	ulcerative	ulcerative	JJ	JJ	_	43	amod	_	_
43	colitis	colitis	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	MATERIALS	material	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Eleven	eleven	CD	CD	_	6	nummod	_	_
6	patients	patient	NNS	NNS	_	28	nsubjpass	_	_
7	with	with	IN	IN	_	9	case	_	_
8	ulcerative	ulcerative	JJ	JJ	_	9	amod	_	_
9	colitis	colitis	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	5	5	CD	CD	_	6	dep	_	_
12	who	who	WP	WP	_	13	nsubj	_	_
13	responded	respond	VBD	VBD	_	11	acl:relcl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	intravenous	intravenous	JJ	JJ	_	16	amod	_	_
16	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	6	6	CD	CD	_	11	conj	_	_
19	who	who	WP	WP	_	20	nsubj	_	_
20	did	do	VBD	VBD	_	18	acl:relcl	_	_
21	not	not	RB	RB	_	20	neg	_	_
22	)	)	-RRB-	-RRB-	_	11	punct	_	_
23	and	and	CC	CC	_	6	cc	_	_
24	ten	ten	CD	CD	_	26	nummod	_	_
25	control	control	JJ	JJ	_	26	amod	_	_
26	subjects	subject	NNS	NNS	_	6	conj	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	studied	study	VBN	VBN	_	1	dep	_	_
29	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	number	number	NN	NN	_	11	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	apparent	apparent	JJ	JJ	_	6	amod	_	_
5	dissociation	dissociation	NN	NN	_	6	compound	_	_
6	constant	constant	NN	NN	_	2	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	2	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	measured	measure	VBN	VBN	_	0	root	_	_
12	using	use	VBG	VBG	_	11	xcomp	_	_
13	a	a	DT	DT	_	16	det	_	_
14	whole-cell	whole-cell	JJ	JJ	_	16	amod	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	assay	assay	NN	NN	_	12	dobj	_	_
17	.	.	.	.	_	11	punct	_	_

1	Results	result	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	median	median	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	interquartile	interquartile	JJ	JJ	_	9	amod	_	_
9	range	range	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	.	.	.	.	_	3	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	number	number	NN	NN	_	21	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	from	from	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	dep	_	_
10	six	six	CD	CD	_	11	nummod	_	_
11	nonresponders	nonresponder	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	five	five	CD	CD	_	14	nummod	_	_
14	responders	responder	NNS	NNS	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	ten	ten	CD	CD	_	19	nummod	_	_
18	healthy	healthy	JJ	JJ	_	19	amod	_	_
19	controls	control	NNS	NNS	_	11	conj	_	_
20	were	be	VBD	VBD	_	21	cop	_	_
21	4922	4922	CD	CD	_	1	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	range	range	NN	NN	_	21	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	4484-5643	4484-5643	CD	CD	_	23	amod	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	,	,	,	,	_	21	punct	_	_
28	3413	3413	CD	CD	_	21	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	range	range	NN	NN	_	28	dep	_	_
31	,	,	,	,	_	30	punct	_	_
32	3183-4450	3183-4450	CD	CD	_	30	amod	_	_
33	)	)	-RRB-	-RRB-	_	30	punct	_	_
34	,	,	,	,	_	21	punct	_	_
35	and	and	CC	CC	_	21	cc	_	_
36	3610	3610	CD	CD	_	21	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	range	range	NN	NN	_	36	dep	_	_
39	,	,	,	,	_	38	punct	_	_
40	2594-3979	2594-3979	CD	CD	_	38	amod	_	_
41	)	)	-RRB-	-RRB-	_	38	punct	_	_
42	binding	bind	VBG	VBG	_	43	amod	_	_
43	sites/cell	sites/cell	NNS	NNS	_	21	dep	_	_
44	,	,	,	,	_	21	punct	_	_
45	respectively	respectively	RB	RB	_	21	advmod	_	_
46	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	apparent	apparent	JJ	JJ	_	4	amod	_	_
3	dissociation	dissociation	NN	NN	_	4	compound	_	_
4	constant	constant	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	4	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	nonresponders	nonresponder	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	responders	responder	NNS	NNS	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	healthy	healthy	JJ	JJ	_	17	amod	_	_
17	controls	control	NNS	NNS	_	11	conj	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	7.03	7.03	CD	CD	_	0	root	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	range	range	NN	NN	_	19	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	5.66-10	5.66-10	CD	CD	_	21	amod	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	,	,	,	,	_	19	punct	_	_
26	4.27	4.27	CD	CD	_	19	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	range	range	NN	NN	_	26	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	4-5.13	4-5.13	CD	CD	_	28	amod	_	_
31	)	)	-RRB-	-RRB-	_	28	punct	_	_
32	,	,	,	,	_	19	punct	_	_
33	and	and	CC	CC	_	19	cc	_	_
34	6.18	6.18	CD	CD	_	19	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	range	range	NN	NN	_	34	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	5.86-6.74	5.86-6.74	CD	CD	_	36	amod	_	_
39	)	)	-RRB-	-RRB-	_	36	punct	_	_
40	nM	nm	NN	NN	_	19	dep	_	_
41	,	,	,	,	_	19	punct	_	_
42	respectively	respectively	RB	RB	_	19	advmod	_	_
43	.	.	.	.	_	19	punct	_	_

1	Nonresponders	nonresponder	NNS	NNS	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	increase	increase	NN	NN	_	2	dobj	_	_
6	both	both	CC	CC	_	9	cc:preconj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	sites	site	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	apparent	apparent	JJ	JJ	_	18	amod	_	_
17	dissociation	dissociation	NN	NN	_	18	compound	_	_
18	constant	constant	NN	NN	_	9	conj	_	_
19	compared	compare	VBN	VBN	_	21	case	_	_
20	with	with	IN	IN	_	21	case	_	_
21	responders	responder	NNS	NNS	_	2	advcl	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	P	p	NN	NN	_	2	dep	_	_
24	=	=	JJ	JJ	_	23	amod	_	_
25	0.045	0.045	CD	CD	_	24	dep	_	_
26	;	;	:	:	_	23	punct	_	_
27	P	p	NN	NN	_	23	dep	_	_
28	=	=	JJ	JJ	_	27	amod	_	_
29	0.029	0.029	CD	CD	_	28	dep	_	_
30	)	)	-RRB-	-RRB-	_	23	punct	_	_
31	.	.	.	.	_	2	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	5	dep	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	number	number	NN	NN	_	15	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	apparent	apparent	JJ	JJ	_	9	amod	_	_
8	dissociation	dissociation	NN	NN	_	9	compound	_	_
9	constant	constant	NN	NN	_	5	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	5	nmod	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	closely	closely	RB	RB	_	15	advmod	_	_
15	associated	associate	VBN	VBN	_	1	dep	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effectiveness	effectiveness	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	therapy	therapy	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	measurement	measurement	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	apparent	apparent	JJ	JJ	_	9	amod	_	_
8	dissociation	dissociation	NN	NN	_	9	compound	_	_
9	constant	constant	NN	NN	_	5	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	5	nmod	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	useful	useful	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	predicting	predict	VBG	VBG	_	15	advcl	_	_
18	response	response	NN	NN	_	17	dobj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	glucocorticoids	glucocorticoid	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	Switching	switch	VBG	VBG	_	0	root	_	_
2	gears	gear	NNS	NNS	_	1	dobj	_	_
3	during	during	IN	IN	_	5	case	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	maturation	maturation	NN	NN	_	1	nmod	_	_
6	:	:	:	:	_	1	punct	_	_
7	RANTES	rantes	NN	NN	_	1	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	late	late	JJ	JJ	_	10	amod	_	_
10	transcription	transcription	NN	NN	_	7	conj	_	_
11	.	.	.	.	_	1	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	much	much	JJ	JJ	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	understood	understand	VBN	VBN	_	23	advcl	_	_
5	about	about	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	genes	gene	NNS	NNS	_	7	nmod	_	_
10	expressed	express	VBN	VBN	_	9	acl	_	_
11	early	early	RB	RB	_	19	advmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	within	within	IN	IN	_	15	case	_	_
14	24	24	CD	CD	_	15	nummod	_	_
15	h	h	NN	NN	_	11	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	after	after	IN	IN	_	19	case	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	10	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	little	little	JJ	JJ	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	known	know	VBN	VBN	_	0	root	_	_
24	about	about	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	regulation	regulation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	expression	expression	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	genes	gene	NNS	NNS	_	28	nmod	_	_
31	expressed	express	VBN	VBN	_	30	acl	_	_
32	'	'	``	``	_	33	punct	_	_
33	late	late	JJ	JJ	_	41	advmod	_	_
34	'	'	''	''	_	33	punct	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	three	three	CD	CD	_	41	dep	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	more	more	JJR	JJR	_	36	conj	_	_
39	days	day	NNS	NNS	_	36	dep	_	_
40	)	)	-RRB-	-RRB-	_	36	punct	_	_
41	post-stimulation	post-stimulation	NN	NN	_	31	dobj	_	_
42	.	.	.	.	_	23	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	better	better	JJR	JJR	_	3	amod	_	_
3	understanding	understanding	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	regulation	regulation	NN	NN	_	3	nmod	_	_
7	at	at	IN	IN	_	10	case	_	_
8	this	this	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	stage	stage	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	maturation	maturation	NN	NN	_	10	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	yield	yield	VB	VB	_	0	root	_	_
16	new	new	JJ	JJ	_	17	amod	_	_
17	insights	insight	NNS	NNS	_	15	dobj	_	_
18	into	into	IN	IN	_	20	case	_	_
19	T-cell	t-cell	NN	NN	_	20	compound	_	_
20	development	development	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	new	new	JJ	JJ	_	24	amod	_	_
23	immunotherapeutic	immunotherapeutic	JJ	JJ	_	22	dep	_	_
24	targets	target	NNS	NNS	_	17	conj	_	_
25	.	.	.	.	_	15	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	interactions	interaction	NNS	NNS	_	1	nmod	_	_
4	between	between	IN	IN	_	7	case	_	_
5	huGATA-3	hugata-3	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	three	three	CD	CD	_	12	nummod	_	_
10	GATA	gata	NN	NN	_	12	compound	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	elements	element	NNS	NNS	_	7	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	1	punct	_	_
19	by	by	IN	IN	_	22	case	_	_
20	surface	surface	NN	NN	_	22	compound	_	_
21	plasmon	plasmon	NN	NN	_	22	compound	_	_
22	resonance	resonance	NN	NN	_	1	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	Relative	relative	JJ	JJ	_	2	amod	_	_
2	affinities	affinity	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	2	nmod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	respective	respective	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	2	nmod	_	_
11	have	have	VBP	VBP	_	14	aux	_	_
12	been	be	VBN	VBN	_	14	auxpass	_	_
13	essentially	essentially	RB	RB	_	14	advmod	_	_
14	studied	study	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	bandshift	bandshift	NN	NN	_	17	compound	_	_
17	analysis	analysis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	real-time	real-time	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	factor/DNA	factor/dna	NN	NN	_	9	compound	_	_
9	interactions	interaction	NNS	NNS	_	6	nmod	_	_
10	using	use	VBG	VBG	_	6	acl	_	_
11	a	a	DT	DT	_	15	det	_	_
12	surface	surface	NN	NN	_	15	compound	_	_
13	plasmon	plasmon	NN	NN	_	15	compound	_	_
14	resonance	resonance	NN	NN	_	15	compound	_	_
15	approach	approach	NN	NN	_	10	dobj	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	further	further	JJ	JJ	_	18	amod	_	_
18	characterization	characterization	NN	NN	_	6	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	recovered	recover	VBN	VBN	_	21	amod	_	_
21	proteins	protein	NNS	NNS	_	18	nmod	_	_
22	involved	involve	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	interaction	interaction	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	purpose	purpose	NN	NN	_	36	nmod	_	_
4	,	,	,	,	_	36	punct	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	GATA-3	gata-3	NN	NN	_	36	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	either	either	CC	CC	_	6	dep	_	_
9	recombinant	recombinant	JJ	JJ	_	8	dep	_	_
10	or	or	CC	CC	_	8	cc	_	_
11	in	in	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	8	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	three	three	CD	CD	_	19	nummod	_	_
17	natural	natural	JJ	JJ	_	19	amod	_	_
18	GATA	gata	NN	NN	_	19	compound	_	_
19	elements	element	NNS	NNS	_	6	conj	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	HIV-1	hiv-1	NN	NN	_	25	compound	_	_
23	long	long	JJ	JJ	_	25	amod	_	_
24	terminal	terminal	JJ	JJ	_	25	amod	_	_
25	repeat	repeat	NN	NN	_	19	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	sites	site	NNS	NNS	_	19	appos	_	_
28	1	1	CD	CD	_	27	dep	_	_
29	,	,	,	,	_	27	punct	_	_
30	2	2	CD	CD	_	27	conj	_	_
31	,	,	,	,	_	27	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	3	3	CD	CD	_	27	conj	_	_
34	)	)	-RRB-	-RRB-	_	27	punct	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	chosen	choose	VBN	VBN	_	0	root	_	_
37	,	,	,	,	_	36	punct	_	_
38	in	in	IN	IN	_	39	case	_	_
39	which	which	WDT	WDT	_	47	nmod	_	_
40	only	only	JJ	JJ	_	41	amod	_	_
41	site	site	NN	NN	_	47	nsubj	_	_
42	2	2	CD	CD	_	41	nummod	_	_
43	is	be	VBZ	VBZ	_	47	cop	_	_
44	a	a	DT	DT	_	47	det	_	_
45	noncanonical	noncanonical	JJ	JJ	_	47	amod	_	_
46	GATA	gata	NN	NN	_	47	compound	_	_
47	site	site	NN	NN	_	36	dep	_	_
48	.	.	.	.	_	36	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	sensorgrams	sensorgram	NNS	NNS	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	with	with	IN	IN	_	8	case	_	_
7	recombinant	recombinant	JJ	JJ	_	8	amod	_	_
8	huGATA-3	hugata-3	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	allowed	allow	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	comparison	comparison	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	association	association	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	dissociation	dissociation	NN	NN	_	14	conj	_	_
17	profiles	profile	NNS	NNS	_	14	dep	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	three	three	CD	CD	_	22	nummod	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	regions	region	NNS	NNS	_	14	nmod	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	ranking	ranking	NN	NN	_	12	conj	_	_
26	according	accord	VBG	VBG	_	30	case	_	_
27	to	to	TO	TO	_	26	mwe	_	_
28	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
29	relative	relative	JJ	JJ	_	30	amod	_	_
30	affinities	affinity	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	confirmed	confirm	VBN	VBN	_	2	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	competitions	competition	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	each	each	DT	DT	_	10	det	_	_
9	GATA	gata	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	16	det	_	_
14	higher	higher	JJR	JJR	_	16	amod	_	_
15	relative	relative	JJ	JJ	_	14	dep	_	_
16	affinity	affinity	NN	NN	_	12	dobj	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	at	at	IN	IN	_	19	case	_	_
19	least	least	JJS	JJS	_	20	advmod	_	_
20	sevenfold	sevenfold	JJ	JJ	_	16	dep	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	of	of	IN	IN	_	23	case	_	_
23	site	site	NN	NN	_	16	nmod	_	_
24	3	3	CD	CD	_	23	nummod	_	_
25	.	.	.	.	_	12	punct	_	_

1	Interactions	interaction	NNS	NNS	_	15	nsubjpass	_	_
2	between	between	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	canonical	canonical	JJ	JJ	_	8	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	unique	unique	JJ	JJ	_	4	conj	_	_
7	GATA	gata	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	1	nmod	_	_
9	3	3	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	extracts	extract	NNS	NNS	_	8	conj	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	studied	study	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	real	real	JJ	JJ	_	18	amod	_	_
18	time	time	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	provided	provide	VBD	VBD	_	15	conj	_	_
21	information	information	NN	NN	_	20	dobj	_	_
22	on	on	IN	IN	_	24	case	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	association	association	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	dissociation	dissociation	NN	NN	_	24	conj	_	_
27	rates	rate	NNS	NNS	_	24	dep	_	_
28	for	for	IN	IN	_	30	case	_	_
29	native	native	JJ	JJ	_	30	amod	_	_
30	huGATA-3	hugata-3	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	recovered	recover	VBN	VBN	_	4	amod	_	_
4	protein	protein	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	9	case	_	_
8	genuine	genuine	JJ	JJ	_	9	amod	_	_
9	huGATA-3	hugata-3	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	SDS-PAGE	sds-page	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	Western	western	NN	NN	_	14	compound	_	_
14	blotting	blotting	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	bandshift	bandshift	NN	NN	_	11	conj	_	_
18	assays	assay	NNS	NNS	_	11	dep	_	_
19	.	.	.	.	_	6	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1997	1997	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	oncogene	oncogene	NN	NN	_	5	compound	_	_
5	product	product	NN	NN	_	10	nsubj	_	_
6	latent	latent	JJ	JJ	_	8	amod	_	_
7	membrane	membrane	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	dep	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	engages	engage	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	18	det	_	_
12	tumor	tumor	NN	NN	_	18	compound	_	_
13	necrosis	necrosis	NN	NN	_	18	compound	_	_
14	factor	factor	NN	NN	_	18	compound	_	_
15	receptor-associated	receptor-associated	JJ	JJ	_	18	amod	_	_
16	death	death	NN	NN	_	18	compound	_	_
17	domain	domain	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	10	dobj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	mediate	mediate	VB	VB	_	10	advcl	_	_
21	B	b	NN	NN	_	24	compound	_	_
22	lymphocyte	lymphocyte	NN	NN	_	24	compound	_	_
23	growth	growth	NN	NN	_	24	compound	_	_
24	transformation	transformation	NN	NN	_	20	dobj	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	activate	activate	VB	VB	_	20	conj	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	26	dobj	_	_
28	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
3	virus	virus	NN	NN	_	12	nsubj	_	_
4	latent	latent	JJ	JJ	_	6	amod	_	_
5	membrane	membrane	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	3	dep	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	LMP1	lmp1	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	essential	essential	JJ	JJ	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	transformation	transformation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
19	into	into	IN	IN	_	22	case	_	_
20	lymphoblastoid	lymphoblastoid	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	model	model	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	LMP1	lmp1	NN	NN	_	14	nsubj	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	constitutively	constitutively	RB	RB	_	14	advmod	_	_
13	activated	activate	VBN	VBN	_	14	amod	_	_
14	receptor	receptor	NN	NN	_	7	ccomp	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	transduces	transduce	VBZ	VBZ	_	14	acl:relcl	_	_
17	signals	signal	NNS	NNS	_	16	dobj	_	_
18	for	for	IN	IN	_	19	case	_	_
19	transformation	transformation	NN	NN	_	16	nmod	_	_
20	through	through	IN	IN	_	24	case	_	_
21	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
22	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	24	amod	_	_
23	cytoplasmic	cytoplasmic	JJ	JJ	_	24	amod	_	_
24	tail	tail	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	4	nummod	_	_
2	transformation	transformation	NN	NN	_	4	compound	_	_
3	effector	effector	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	22	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	TES1	tes1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	located	located	JJ	JJ	_	4	amod	_	_
10	within	within	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	membrane	membrane	NN	NN	_	15	compound	_	_
13	proximal	proximal	JJ	JJ	_	15	amod	_	_
14	45	45	CD	CD	_	15	nummod	_	_
15	residues	residue	NNS	NNS	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	cytoplasmic	cytoplasmic	JJ	JJ	_	19	amod	_	_
19	tail	tail	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	4	punct	_	_
21	constitutively	constitutively	RB	RB	_	22	advmod	_	_
22	engages	engage	VBZ	VBZ	_	0	root	_	_
23	tumor	tumor	NN	NN	_	27	compound	_	_
24	necrosis	necrosis	NN	NN	_	27	compound	_	_
25	factor	factor	NN	NN	_	27	compound	_	_
26	receptor-associated	receptor-associated	JJ	JJ	_	27	amod	_	_
27	factors	factor	NNS	NNS	_	22	dobj	_	_
28	.	.	.	.	_	22	punct	_	_

1	Signals	signal	NNS	NNS	_	5	nsubj	_	_
2	from	from	IN	IN	_	3	case	_	_
3	TES1	tes1	NN	NN	_	1	nmod	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	sufficient	sufficient	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	drive	drive	VB	VB	_	5	xcomp	_	_
8	initial	initial	JJ	JJ	_	9	amod	_	_
9	proliferation	proliferation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	infected	infected	JJ	JJ	_	13	amod	_	_
12	resting	rest	VBG	VBG	_	11	dep	_	_
13	B	b	NN	NN	_	9	nmod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	13	dep	_	_
15	,	,	,	,	_	5	punct	_	_
16	but	but	CC	CC	_	5	cc	_	_
17	most	most	JJS	JJS	_	19	amod	_	_
18	lymphoblastoid	lymphoblastoid	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	33	nsubj	_	_
20	infected	infect	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	virus	virus	NN	NN	_	20	nmod	_	_
24	that	that	WDT	WDT	_	27	nsubj	_	_
25	does	do	VBZ	VBZ	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	express	express	VB	VB	_	23	acl:relcl	_	_
28	the	the	DT	DT	_	30	det	_	_
29	155	155	CD	CD	_	30	nummod	_	_
30	residues	residue	NNS	NNS	_	27	dobj	_	_
31	beyond	beyond	IN	IN	_	32	case	_	_
32	TES1	tes1	NN	NN	_	27	nmod	_	_
33	fail	fail	VBP	VBP	_	5	conj	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	grow	grow	VB	VB	_	33	xcomp	_	_
36	as	as	IN	IN	_	39	case	_	_
37	long-term	long-term	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	lines	line	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	find	find	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	mutating	mutate	VBG	VBG	_	19	csubj	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	tyrosines	tyrosine	NNS	NNS	_	5	dobj	_	_
8	to	to	TO	TO	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	isoleucine	isoleucine	NN	NN	_	5	nmod	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	carboxyl	carboxyl	NN	NN	_	14	compound	_	_
14	end	end	NN	NN	_	5	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cytoplasmic	cytoplasmic	JJ	JJ	_	18	amod	_	_
18	tail	tail	NN	NN	_	14	nmod	_	_
19	cripples	cripple	VBZ	VBZ	_	3	ccomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	ability	ability	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	EBV	ebv	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	cause	cause	VB	VB	_	21	acl	_	_
26	lymphoblastoid	lymphoblastoid	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	outgrowth	outgrowth	NN	NN	_	25	dobj	_	_
29	,	,	,	,	_	19	punct	_	_
30	thereby	thereby	RB	RB	_	31	advmod	_	_
31	marking	mark	VBG	VBG	_	19	advcl	_	_
32	a	a	DT	DT	_	36	det	_	_
33	second	second	JJ	JJ	_	36	amod	_	_
34	transformation	transformation	NN	NN	_	36	compound	_	_
35	effector	effector	NN	NN	_	36	compound	_	_
36	site	site	NN	NN	_	31	dobj	_	_
37	,	,	,	,	_	36	punct	_	_
38	TES2	tes2	NN	NN	_	36	appos	_	_
39	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	yeast	yeast	NN	NN	_	4	compound	_	_
3	two-hybrid	two-hybrid	JJ	JJ	_	4	amod	_	_
4	screen	screen	NN	NN	_	5	nsubj	_	_
5	identified	identify	VBD	VBD	_	0	root	_	_
6	TES2	tes2	NN	NN	_	8	compound	_	_
7	interacting	interacting	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	including	include	VBG	VBG	_	18	case	_	_
11	the	the	DT	DT	_	18	det	_	_
12	tumor	tumor	NN	NN	_	18	compound	_	_
13	necrosis	necrosis	NN	NN	_	18	compound	_	_
14	factor	factor	NN	NN	_	18	compound	_	_
15	receptor-associated	receptor-associated	JJ	JJ	_	18	amod	_	_
16	death	death	NN	NN	_	18	compound	_	_
17	domain	domain	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	8	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TRADD	tradd	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	5	punct	_	_

1	TRADD	tradd	NN	NN	_	5	nsubj	_	_
2	was	be	VBD	VBD	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	only	only	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	interacted	interact	VBD	VBD	_	5	acl:relcl	_	_
8	with	with	IN	IN	_	10	case	_	_
9	wild-type	wild-type	JJ	JJ	_	10	amod	_	_
10	TES2	tes2	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	with	with	IN	IN	_	15	case	_	_
14	isoleucine-mutated	isoleucine-mutated	JJ	JJ	_	15	amod	_	_
15	TES2	tes2	NN	NN	_	10	conj	_	_
16	.	.	.	.	_	5	punct	_	_

1	TRADD	tradd	NN	NN	_	2	nsubj	_	_
2	associated	associate	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	5	case	_	_
4	wild-type	wild-type	JJ	JJ	_	5	amod	_	_
5	LMP1	lmp1	NN	NN	_	2	nmod	_	_
6	but	but	CC	CC	_	5	cc	_	_
7	not	not	RB	RB	_	10	neg	_	_
8	with	with	IN	IN	_	10	case	_	_
9	isoleucine-mutated	isoleucine-mutated	JJ	JJ	_	10	amod	_	_
10	LMP1	lmp1	NN	NN	_	5	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	mammalian	mammalian	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	TRADD	tradd	NN	NN	_	18	nsubj	_	_
17	constitutively	constitutively	RB	RB	_	18	advmod	_	_
18	associated	associate	VBD	VBD	_	2	conj	_	_
19	with	with	IN	IN	_	20	case	_	_
20	LMP1	lmp1	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	EBV-transformed	ebv-transformed	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	TRADD	tradd	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	TES2	tes2	NN	NN	_	5	conj	_	_
8	synergistically	synergistically	RB	RB	_	9	advmod	_	_
9	mediated	mediate	VBD	VBD	_	0	root	_	_
10	high-level	high-level	JJ	JJ	_	12	amod	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	LMP1	lmp1	NN	NN	_	6	nsubj	_	_
6	appropriates	appropriate	VBZ	VBZ	_	3	ccomp	_	_
7	TRADD	tradd	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	enable	enable	VB	VB	_	6	advcl	_	_
10	efficient	efficient	JJ	JJ	_	14	amod	_	_
11	long-term	long-term	JJ	JJ	_	10	dep	_	_
12	lymphoblastoid	lymphoblastoid	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	outgrowth	outgrowth	NN	NN	_	9	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	High-level	high-level	JJ	JJ	_	3	amod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	appears	appear	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	critical	critical	JJ	JJ	_	10	amod	_	_
10	component	component	NN	NN	_	5	xcomp	_	_
11	of	of	IN	IN	_	13	case	_	_
12	long-term	long-term	JJ	JJ	_	13	amod	_	_
13	outgrowth	outgrowth	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	13	case	_	_
6	a	a	DT	DT	_	13	det	_	_
7	novel	novel	JJ	JJ	_	13	amod	_	_
8	human	human	JJ	JJ	_	13	amod	_	_
9	myeloid-selective	myeloid-selective	JJ	JJ	_	13	amod	_	_
10	CCAAT/enhancer	ccaat/enhancer	NN	NN	_	13	compound	_	_
11	binding	binding	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	4	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	C/EBP	c/ebp	NN	NN	_	16	compound	_	_
16	epsilon	epsilon	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	C/EBP	c/ebp	NN	NN	_	3	compound	_	_
3	epsilon	epsilon	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	a	a	DT	DT	_	8	det	_	_
6	newly	newly	RB	RB	_	7	advmod	_	_
7	cloned	clone	VBN	VBN	_	8	amod	_	_
8	gene	gene	NN	NN	_	0	root	_	_
9	coding	code	VBG	VBG	_	8	acl	_	_
10	for	for	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	CCAAT/enhancer	ccaat/enhancer	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	9	nmod	_	_
15	that	that	WDT	WDT	_	18	nsubjpass	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	involved	involve	VBN	VBN	_	8	acl:relcl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	regulation	regulation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	levels	level	NNS	NNS	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	C/EBP	c/ebp	NN	NN	_	9	compound	_	_
8	epsilon	epsilon	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	5	nmod	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	markedly	markedly	RB	RB	_	12	advmod	_	_
12	increased	increase	VBN	VBN	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	NB4	nb4	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	promyelocytic	promyelocytic	JJ	JJ	_	19	amod	_	_
18	leukemia	leukemia	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	15	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	12	punct	_	_
22	because	because	IN	IN	_	25	mark	_	_
23	they	they	PRP	PRP	_	25	nsubjpass	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	induced	induce	VBN	VBN	_	12	advcl	_	_
26	by	by	IN	IN	_	29	case	_	_
27	9-cis	9-cis	JJ	JJ	_	29	amod	_	_
28	retinoic	retinoic	JJ	JJ	_	29	amod	_	_
29	acid	acid	NN	NN	_	35	nmod	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	9-cis	9-cis	JJ	JJ	_	32	amod	_	_
32	RA	ra	NN	NN	_	29	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	differentiate	differentiate	VB	VB	_	25	xcomp	_	_
36	towards	towards	IN	IN	_	37	case	_	_
37	granulocytes	granulocyte	NNS	NNS	_	35	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Accumulation	accumulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	C/EBP	c/ebp	NN	NN	_	5	compound	_	_
4	epsilon	epsilon	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	1	nmod	_	_
6	occurred	occur	VBD	VBD	_	0	root	_	_
7	as	as	RB	RB	_	8	advmod	_	_
8	early	early	RB	RB	_	6	advmod	_	_
9	as	as	IN	IN	_	11	case	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	hour	hour	NN	NN	_	8	nmod	_	_
12	after	after	IN	IN	_	11	case	_	_
13	exposure	exposure	NN	NN	_	11	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NB4	nb4	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	9-cis	9-cis	JJ	JJ	_	19	amod	_	_
19	RA	ra	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	5	5	CD	CD	_	24	nummod	_	_
22	x	x	CC	CC	_	21	cc	_	_
23	10(-7)	10(-7)	CD	CD	_	21	conj	_	_
24	mol/L	mol/l	NN	NN	_	19	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	;	;	:	:	_	6	punct	_	_
27	and	and	CC	CC	_	6	cc	_	_
28	at	at	IN	IN	_	30	case	_	_
29	48	48	CD	CD	_	30	nummod	_	_
30	hours	hour	NNS	NNS	_	34	nmod	_	_
31	,	,	,	,	_	34	punct	_	_
32	levels	level	NNS	NNS	_	34	nsubjpass	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	increased	increase	VBN	VBN	_	6	conj	_	_
35	by	by	IN	IN	_	36	case	_	_
36	5.1-fold	5.1-fold	RB	RB	_	34	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	Dose-response	dose-response	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	10(-7)	10(-7)	CD	CD	_	7	compound	_	_
6	to	to	TO	TO	_	7	dep	_	_
7	10(-6)	10(-6)	CD	CD	_	8	dep	_	_
8	mol/L	mol/l	NN	NN	_	10	dep	_	_
9	9-cis	9-cis	JJ	JJ	_	10	amod	_	_
10	RA	ra	NN	NN	_	15	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	12	12	CD	CD	_	13	nummod	_	_
13	hours	hour	NNS	NNS	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	resulted	result	VBD	VBD	_	3	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	peak	peak	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	C/EBP	c/ebp	NN	NN	_	22	compound	_	_
21	epsilon	epsilon	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	18	nmod	_	_
23	;	;	:	:	_	3	punct	_	_
24	but	but	CC	CC	_	3	cc	_	_
25	even	even	RB	RB	_	29	advmod	_	_
26	10(-10)	10(-10)	CD	CD	_	27	compound	_	_
27	mol/L	mol/l	NN	NN	_	29	amod	_	_
28	9-cis	9-cis	JJ	JJ	_	29	amod	_	_
29	RA	ra	NN	NN	_	30	nsubj	_	_
30	increased	increase	VBD	VBD	_	3	conj	_	_
31	levels	level	NNS	NNS	_	30	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	these	these	DT	DT	_	34	det	_	_
34	transcripts	transcript	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	NB4	nb4	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	36	nsubj	_	_
3	pulse-exposed	pulse-exposed	JJ	JJ	_	2	amod	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	30	30	CD	CD	_	6	nummod	_	_
6	minutes	minute	NNS	NNS	_	3	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	to	to	TO	TO	_	11	case	_	_
9	all-trans	all-trans	JJ	JJ	_	11	amod	_	_
10	retinoic	retinoic	JJ	JJ	_	11	amod	_	_
11	acid	acid	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	ATRA	atra	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	3	punct	_	_
16	washed	wash	VBN	VBN	_	3	conj	_	_
17	,	,	,	,	_	3	punct	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	cultured	culture	VBN	VBN	_	3	conj	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	3	3	CD	CD	_	22	nummod	_	_
22	days	day	NNS	NNS	_	19	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	with	with	IN	IN	_	26	case	_	_
25	either	either	CC	CC	_	26	cc:preconj	_	_
26	dimethylsulfoxide	dimethylsulfoxide	NN	NN	_	19	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	DMSO	dmso	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	or	or	CC	CC	_	26	cc	_	_
31	hexamethylene	hexamethylene	NN	NN	_	32	compound	_	_
32	bisacetamide	bisacetamide	NN	NN	_	26	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	HMBA	hmba	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	had	have	VBD	VBD	_	0	root	_	_
37	a	a	DT	DT	_	39	det	_	_
38	prominent	prominent	JJ	JJ	_	39	amod	_	_
39	increase	increase	NN	NN	_	36	dobj	_	_
40	in	in	IN	IN	_	41	case	_	_
41	levels	level	NNS	NNS	_	39	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	C/EBP	c/ebp	NN	NN	_	45	compound	_	_
44	epsilon	epsilon	NN	NN	_	45	compound	_	_
45	mRNA	mrna	NN	NN	_	41	nmod	_	_
46	and	and	CC	CC	_	39	cc	_	_
47	an	a	DT	DT	_	48	det	_	_
48	increase	increase	NN	NN	_	39	conj	_	_
49	in	in	IN	IN	_	51	case	_	_
50	granulocytic	granulocytic	JJ	JJ	_	51	amod	_	_
51	differentiation	differentiation	NN	NN	_	48	nmod	_	_
52	,	,	,	,	_	36	punct	_	_
53	but	but	CC	CC	_	36	cc	_	_
54	exposure	exposure	NN	NN	_	61	nsubj	_	_
55	to	to	TO	TO	_	57	case	_	_
56	either	either	CC	CC	_	57	cc:preconj	_	_
57	DMSO	dmso	NN	NN	_	54	nmod	_	_
58	or	or	CC	CC	_	57	cc	_	_
59	HMBA	hmba	NN	NN	_	57	conj	_	_
60	alone	alone	RB	RB	_	57	advmod	_	_
61	had	have	VBD	VBD	_	36	conj	_	_
62	no	no	DT	DT	_	63	neg	_	_
63	effect	effect	NN	NN	_	61	dobj	_	_
64	on	on	IN	IN	_	66	case	_	_
65	base	base	NN	NN	_	66	compound	_	_
66	levels	level	NNS	NNS	_	61	nmod	_	_
67	of	of	IN	IN	_	69	case	_	_
68	C/EBP	c/ebp	NN	NN	_	69	compound	_	_
69	epsilon	epsilon	NN	NN	_	66	nmod	_	_
70	and	and	CC	CC	_	61	cc	_	_
71	did	do	VBD	VBD	_	73	aux	_	_
72	not	not	RB	RB	_	73	neg	_	_
73	induce	induce	VB	VB	_	61	conj	_	_
74	differentiation	differentiation	NN	NN	_	73	dobj	_	_
75	.	.	.	.	_	36	punct	_	_

1	Macrophage-differentiation	macrophage-differentiation	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NB4	nb4	NN	NN	_	1	nmod	_	_
4	reduced	reduce	VBD	VBD	_	0	root	_	_
5	levels	level	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	C/EBP	c/ebp	NN	NN	_	9	compound	_	_
8	epsilon	epsilon	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-off	run-off	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	half-life	half-life	JJ	JJ	_	6	amod	_	_
6	studies	study	NNS	NNS	_	3	conj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	accumulation	accumulation	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	C/EBP	c/ebp	NN	NN	_	13	compound	_	_
12	epsilon	epsilon	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	9	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	9-cis	9-cis	JJ	JJ	_	16	amod	_	_
16	RA	ra	NN	NN	_	9	nmod	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	due	due	JJ	JJ	_	7	ccomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	enhanced	enhance	VBN	VBN	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	this	this	DT	DT	_	7	det	_	_
4	C/EBP	c/ebp	NN	NN	_	6	compound	_	_
5	epsilon	epsilon	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	accumulation	accumulation	NN	NN	_	10	nsubj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	require	require	VB	VB	_	0	root	_	_
11	synthesis	synthesis	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	new	new	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	because	because	IN	IN	_	19	mark	_	_
17	9-cis	9-cis	JJ	JJ	_	18	amod	_	_
18	RA	ra	NN	NN	_	19	nsubj	_	_
19	induced	induce	VBD	VBD	_	10	advcl	_	_
20	C/EBP	c/ebp	NN	NN	_	22	compound	_	_
21	epsilon	epsilon	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	23	compound	_	_
23	accumulation	accumulation	NN	NN	_	19	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	absence	absence	NN	NN	_	19	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	new	new	JJ	JJ	_	30	amod	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	synthesis	synthesis	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	ATRA	atra	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	C/EBP	c/ebp	NN	NN	_	8	compound	_	_
7	epsilon	epsilon	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	NB4	nb4	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	shown	show	VBN	VBN	_	3	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	Western	western	NN	NN	_	17	compound	_	_
17	blotting	blotting	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	26	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	increase	increase	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	C/EBP	c/ebp	NN	NN	_	8	compound	_	_
8	epsilon	epsilon	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	9-cis	9-cis	JJ	JJ	_	11	amod	_	_
11	RA-mediated	ra-mediated	JJ	JJ	_	13	amod	_	_
12	granulocytic	granulocytic	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	26	punct	_	_
15	the	the	DT	DT	_	17	det	_	_
16	DMSO-induced	dmso-induced	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	26	nsubjpass	_	_
18	of	of	IN	IN	_	20	case	_	_
19	HL-60	hl-60	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	down	down	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	granulocytic	granulocytic	JJ	JJ	_	24	amod	_	_
24	pathway	pathway	NN	NN	_	17	advmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	associated	associate	VBN	VBN	_	0	root	_	_
27	with	with	IN	IN	_	30	case	_	_
28	an	a	DT	DT	_	30	det	_	_
29	initial	initial	JJ	JJ	_	30	amod	_	_
30	reduction	reduction	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	C/EBP	c/ebp	NN	NN	_	34	compound	_	_
33	epsilon	epsilon	NN	NN	_	34	compound	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	levels	level	NNS	NNS	_	30	nmod	_	_
36	.	.	.	.	_	26	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	discovered	discover	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	expression	expression	NN	NN	_	15	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	C/EBP	c/ebp	NN	NN	_	12	compound	_	_
11	epsilon	epsilon	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	markedly	markedly	RB	RB	_	15	advmod	_	_
15	enhanced	enhance	VBN	VBN	_	6	ccomp	_	_
16	as	as	IN	IN	_	21	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	NB4	nb4	NN	NN	_	19	compound	_	_
19	promyelocytes	promyelocyte	NNS	NNS	_	21	nsubjpass	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	induced	induce	VBN	VBN	_	15	advcl	_	_
22	by	by	IN	IN	_	23	case	_	_
23	retinoids	retinoid	NNS	NNS	_	25	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	differentiate	differentiate	VB	VB	_	21	xcomp	_	_
26	towards	towards	IN	IN	_	27	case	_	_
27	granulocytes	granulocyte	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	C/EBP	c/ebp	NN	NN	_	6	compound	_	_
5	epsilon	epsilon	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	transcriptionally	transcriptionally	RB	RB	_	10	advmod	_	_
10	mediated	mediate	VBN	VBN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	occurs	occur	VBZ	VBZ	_	10	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	absence	absence	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	synthesis	synthesis	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	additional	additional	JJ	JJ	_	21	amod	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suspect	suspect	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
6	epsilon	epsilon	NN	NN	_	7	compound	_	_
7	promoter/enhancer	promoter/enhancer	NN	NN	_	8	nsubj	_	_
8	contains	contain	VBZ	VBZ	_	2	ccomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	retinoic	retinoic	JJ	JJ	_	12	amod	_	_
11	acid-response	acid-response	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	8	dobj	_	_
13	that	that	WDT	WDT	_	16	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	directly	directly	RB	RB	_	16	advmod	_	_
16	stimulated	stimulate	VBN	VBN	_	12	acl:relcl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	retinoids	retinoid	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	c-fos	c-fos	NN	NN	_	1	nmod	_	_
4	correlates	correlate	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	7	compound	_	_
7	responsiveness	responsiveness	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	14	case	_	_
9	Philadelphia	philadelphia	NN	NN	_	14	compound	_	_
10	chromosome	chromosome	NN	NN	_	14	compound	_	_
11	positive	positive	JJ	JJ	_	14	amod	_	_
12	chronic	chronic	JJ	JJ	_	14	amod	_	_
13	myelogenous	myelogenous	JJ	JJ	_	14	amod	_	_
14	leukemia	leukemia	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	evaluates	evaluate	VBZ	VBZ	_	0	root	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	i	i	LS	LS	_	8	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	constitutive	constitutive	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	3	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	oncogene	oncogene	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	p53	p53	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	10	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	chronic	chronic	JJ	JJ	_	18	amod	_	_
16	phase	phase	NN	NN	_	18	compound	_	_
17	CML	cml	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	8	nmod	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ii	ii	LS	LS	_	24	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	modulations	modulation	NNS	NNS	_	8	conj	_	_
25	subsequent	subsequent	JJ	JJ	_	24	amod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	in	in	FW	FW	_	29	amod	_	_
28	vivo	vivo	FW	FW	_	27	dep	_	_
29	therapy	therapy	NN	NN	_	25	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	rIFN-alpha	rifn-alpha	NN	NN	_	32	compound	_	_
32	2c	2c	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	pbmc	pbmc	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	bone	bone	NN	NN	_	11	compound	_	_
10	marrow	marrow	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	26	26	CD	CD	_	14	nummod	_	_
14	patients	patient	NNS	NNS	_	4	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	for	for	IN	IN	_	18	case	_	_
18	c-fos	c-fos	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	c-myc	c-myc	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	p53	p53	NN	NN	_	18	conj	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	hybrid	hybrid	NN	NN	_	26	compound	_	_
26	bcr/abl	bcr/abl	NN	NN	_	18	conj	_	_
27	mRNA	mrna	NN	NN	_	28	compound	_	_
28	levels	level	NNS	NNS	_	18	dep	_	_
29	.	.	.	.	_	16	punct	_	_

1	Results	result	NNS	NNS	_	2	nsubj	_	_
2	indicated	indicate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	i	i	LS	LS	_	13	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	constitutive	constitutive	JJ	JJ	_	10	amod	_	_
8	c-fos	c-fos	NN	NN	_	9	compound	_	_
9	transcript	transcript	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	13	nsubj	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	higher	higher	JJR	JJR	_	2	ccomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	patients	patient	NNS	NNS	_	13	nmod	_	_
16	subsequently	subsequently	RB	RB	_	17	advmod	_	_
17	responding	respond	VBG	VBG	_	15	acl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	IFN-alpha	ifn-alpha	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	p	p	NN	NN	_	13	dep	_	_
23	&lt;	&lt;	JJR	JJR	_	22	amod	_	_
24	0.01	0.01	CD	CD	_	23	dep	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	and	and	CC	CC	_	13	cc	_	_
27	positively	positively	RB	RB	_	28	advmod	_	_
28	correlated	correlate	VBN	VBN	_	13	conj	_	_
29	with	with	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	proportion	proportion	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	31	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	r	r	NN	NN	_	28	dep	_	_
36	=	=	JJ	JJ	_	35	amod	_	_
37	0.6895	0.6895	CD	CD	_	36	dep	_	_
38	,	,	,	,	_	35	punct	_	_
39	p	p	NN	NN	_	35	appos	_	_
40	&lt;	&lt;	JJR	JJR	_	39	amod	_	_
41	0.01	0.01	CD	CD	_	40	dep	_	_
42	)	)	-RRB-	-RRB-	_	35	punct	_	_
43	and	and	CC	CC	_	28	cc	_	_
44	negatively	negatively	RB	RB	_	60	advmod	_	_
45	with	with	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	proportion	proportion	NN	NN	_	60	nmod	_	_
48	of	of	IN	IN	_	50	case	_	_
49	immature	immature	JJ	JJ	_	50	amod	_	_
50	cells	cell	NNS	NNS	_	47	nmod	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	r	r	NN	NN	_	60	dep	_	_
53	=	=	JJ	JJ	_	52	amod	_	_
54	-0.568	-0.568	CD	CD	_	53	dep	_	_
55	,	,	,	,	_	52	punct	_	_
56	p	p	NN	NN	_	52	appos	_	_
57	&lt;	&lt;	JJR	JJR	_	56	amod	_	_
58	0.01	0.01	CD	CD	_	57	dep	_	_
59	)	)	-RRB-	-RRB-	_	52	punct	_	_
60	contained	contain	VBN	VBN	_	28	conj	_	_
61	in	in	IN	IN	_	64	case	_	_
62	the	the	DT	DT	_	64	det	_	_
63	pbmc	pbmc	NN	NN	_	64	compound	_	_
64	preparations	preparation	NNS	NNS	_	60	nmod	_	_
65	tested	test	VBN	VBN	_	64	acl	_	_
66	,	,	,	,	_	13	punct	_	_
67	(	(	-LRB-	-LRB-	_	68	punct	_	_
68	ii	ii	LS	LS	_	83	dep	_	_
69	)	)	-RRB-	-RRB-	_	68	punct	_	_
70	constitutive	constitutive	JJ	JJ	_	71	amod	_	_
71	mRNA	mrna	NN	NN	_	72	compound	_	_
72	levels	level	NNS	NNS	_	83	nsubjpass	_	_
73	of	of	IN	IN	_	76	case	_	_
74	the	the	DT	DT	_	76	det	_	_
75	hybrid	hybrid	NN	NN	_	76	compound	_	_
76	bcr/abl	bcr/abl	NN	NN	_	72	nmod	_	_
77	,	,	,	,	_	76	punct	_	_
78	c-myc	c-myc	NN	NN	_	76	conj	_	_
79	and	and	CC	CC	_	76	cc	_	_
80	p53	p53	NN	NN	_	76	conj	_	_
81	are	be	VBP	VBP	_	83	auxpass	_	_
82	positively	positively	RB	RB	_	83	advmod	_	_
83	correlated	correlate	VBN	VBN	_	13	ccomp	_	_
84	with	with	IN	IN	_	86	case	_	_
85	each	each	DT	DT	_	86	det	_	_
86	other	other	JJ	JJ	_	83	nmod	_	_
87	,	,	,	,	_	83	punct	_	_
88	but	but	CC	CC	_	83	cc	_	_
89	failed	fail	VBD	VBD	_	83	conj	_	_
90	to	to	TO	TO	_	91	mark	_	_
91	relate	relate	VB	VB	_	89	xcomp	_	_
92	to	to	TO	TO	_	94	case	_	_
93	disease	disease	NN	NN	_	94	compound	_	_
94	parameters	parameter	NNS	NNS	_	91	nmod	_	_
95	,	,	,	,	_	13	punct	_	_
96	and	and	CC	CC	_	13	cc	_	_
97	(	(	-LRB-	-LRB-	_	98	punct	_	_
98	iii	iii	LS	LS	_	109	dep	_	_
99	)	)	-RRB-	-RRB-	_	98	punct	_	_
100	acute	acute	JJ	JJ	_	109	nsubjpass	_	_
101	and	and	CC	CC	_	100	cc	_	_
102	chronic	chronic	JJ	JJ	_	100	conj	_	_
103	in	in	FW	FW	_	105	amod	_	_
104	vivo	vivo	FW	FW	_	103	dep	_	_
105	exposure	exposure	NN	NN	_	100	dep	_	_
106	to	to	TO	TO	_	107	case	_	_
107	IFN-alpha	ifn-alpha	NN	NN	_	100	nmod	_	_
108	is	be	VBZ	VBZ	_	109	auxpass	_	_
109	accompanied	accompany	VBN	VBN	_	13	conj	_	_
110	by	by	IN	IN	_	111	case	_	_
111	upregulation	upregulation	NN	NN	_	109	nmod	_	_
112	of	of	IN	IN	_	113	case	_	_
113	c-fos	c-fos	NN	NN	_	111	nmod	_	_
114	and	and	CC	CC	_	111	cc	_	_
115	downregulation	downregulation	NN	NN	_	111	conj	_	_
116	of	of	IN	IN	_	119	case	_	_
117	c-myc	c-myc	NN	NN	_	118	compound	_	_
118	mRNA	mrna	NN	NN	_	119	compound	_	_
119	levels	level	NNS	NNS	_	115	nmod	_	_
120	in	in	IN	IN	_	122	case	_	_
121	responder	responder	NN	NN	_	122	compound	_	_
122	patients	patient	NNS	NNS	_	111	nmod	_	_
123	.	.	.	.	_	2	punct	_	_

1	Paternal	paternal	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	WT1	wt1	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	fibroblasts	fibroblast	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	7	conj	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	Wilms	wilms	NN	NN	_	6	nmod:poss	_	_
3	'	'	POS	POS	_	6	case	_	_
4	tumor	tumor	NN	NN	_	6	compound	_	_
5	suppressor	suppressor	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	12	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	WT1	wt1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	previously	previously	RB	RB	_	12	advmod	_	_
12	identified	identify	VBN	VBN	_	0	root	_	_
13	as	as	IN	IN	_	15	mark	_	_
14	being	be	VBG	VBG	_	15	auxpass	_	_
15	imprinted	imprint	VBN	VBN	_	12	advcl	_	_
16	,	,	,	,	_	15	punct	_	_
17	with	with	IN	IN	_	20	case	_	_
18	frequent	frequent	JJ	JJ	_	20	amod	_	_
19	maternal	maternal	JJ	JJ	_	20	amod	_	_
20	expression	expression	NN	NN	_	15	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	placentae	placentae	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	fetal	fetal	JJ	JJ	_	26	amod	_	_
26	brains	brain	NNS	NNS	_	23	conj	_	_
27	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	allele-specific	allele-specific	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	WT1	wt1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	cultured	culture	VBN	VBN	_	11	amod	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	fibroblasts	fibroblast	NNS	NNS	_	5	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	15	15	CD	CD	_	14	nummod	_	_
14	individuals	individual	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Seven	seven	CD	CD	_	3	compound	_	_
2	of	of	IN	IN	_	3	advmod	_	_
3	15	15	CD	CD	_	5	nummod	_	_
4	fibroblast	fibroblast	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	7	nsubj	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	heterozygous	heterozygous	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	polymorphic	polymorphic	JJ	JJ	_	10	amod	_	_
10	alleles	allele	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	patterns	pattern	NNS	NNS	_	17	nsubj	_	_
16	were	be	VBD	VBD	_	17	cop	_	_
17	variable	variable	JJ	JJ	_	7	conj	_	_
18	,	,	,	,	_	17	punct	_	_
19	i.e.	i.e.	FW	FW	_	17	advcl	_	_
20	,	,	,	,	_	17	punct	_	_
21	equal	equal	JJ	JJ	_	17	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	unequal	unequal	JJ	JJ	_	21	conj	_	_
24	or	or	CC	CC	_	21	cc	_	_
25	monoallelic	monoallelic	JJ	JJ	_	26	amod	_	_
26	paternal	paternal	JJ	JJ	_	21	conj	_	_
27	expression	expression	NN	NN	_	21	dep	_	_
28	in	in	IN	IN	_	29	case	_	_
29	three	three	CD	CD	_	17	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	two	two	CD	CD	_	29	conj	_	_
32	and	and	CC	CC	_	29	cc	_	_
33	two	two	CD	CD	_	29	conj	_	_
34	cases	case	NNS	NNS	_	29	dep	_	_
35	,	,	,	,	_	17	punct	_	_
36	respectively	respectively	RB	RB	_	17	advmod	_	_
37	.	.	.	.	_	7	punct	_	_

1	Exclusive	exclusive	JJ	JJ	_	3	amod	_	_
2	paternal	paternal	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	WT1	wt1	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	non-cultured	non-cultured	JJ	JJ	_	12	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	from	from	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	latter	latter	JJ	JJ	_	17	amod	_	_
16	two	two	CD	CD	_	17	nummod	_	_
17	individuals	individual	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	allele-specific	allele-specific	JJ	JJ	_	4	amod	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	profiles	profile	NNS	NNS	_	19	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	imprinted	imprinted	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	IGF2	igf2	NN	NN	_	8	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	H19	h19	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	on	on	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	chromosome	chromosome	NN	NN	_	8	nmod	_	_
17	11	11	CD	CD	_	16	nummod	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	constant	constant	JJ	JJ	_	0	root	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	consistent	consistent	JJ	JJ	_	19	conj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	those	those	DT	DT	_	21	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	other	other	JJ	JJ	_	26	amod	_	_
26	tissues	tissue	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	unexpected	unexpected	JJ	JJ	_	3	amod	_	_
3	observations	observation	NNS	NNS	_	31	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	paternal	paternal	JJ	JJ	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	biallelic	biallelic	JJ	JJ	_	5	conj	_	_
8	expression	expression	NN	NN	_	5	dep	_	_
9	of	of	IN	IN	_	10	case	_	_
10	WT1	wt1	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	5	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	12	conj	_	_
15	,	,	,	,	_	3	punct	_	_
16	together	together	RB	RB	_	20	advmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	previous	previous	JJ	JJ	_	20	amod	_	_
20	findings	finding	NNS	NNS	_	31	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	maternal	maternal	JJ	JJ	_	20	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	biallelic	biallelic	JJ	JJ	_	22	conj	_	_
25	expression	expression	NN	NN	_	22	dep	_	_
26	in	in	IN	IN	_	27	case	_	_
27	placentae	placentae	NN	NN	_	22	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	brains	brain	NNS	NNS	_	27	conj	_	_
30	,	,	,	,	_	31	punct	_	_
31	suggest	suggest	VBP	VBP	_	0	root	_	_
32	that	that	IN	IN	_	40	mark	_	_
33	the	the	DT	DT	_	36	det	_	_
34	allele-specific	allele-specific	JJ	JJ	_	36	amod	_	_
35	regulatory	regulatory	JJ	JJ	_	36	amod	_	_
36	system	system	NN	NN	_	40	nsubj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	WT1	wt1	NN	NN	_	36	nmod	_	_
39	is	be	VBZ	VBZ	_	40	cop	_	_
40	unique	unique	JJ	JJ	_	31	ccomp	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	may	may	MD	MD	_	44	aux	_	_
43	be	be	VB	VB	_	44	auxpass	_	_
44	controlled	control	VBN	VBN	_	40	conj	_	_
45	by	by	IN	IN	_	51	case	_	_
46	a	a	DT	DT	_	51	det	_	_
47	putative	putative	JJ	JJ	_	51	amod	_	_
48	tissue-	tissue-	NN	NN	_	47	dep	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	individual-specific	individual-specific	JJ	JJ	_	48	conj	_	_
51	modifier	modifier	NN	NN	_	44	nmod	_	_
52	.	.	.	.	_	31	punct	_	_

1	Aberrant	aberrant	JJ	JJ	_	2	amod	_	_
2	splicing	splicing	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	TSG101	tsg101	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	FHIT	fhit	NN	NN	_	5	conj	_	_
8	genes	gene	NNS	NNS	_	5	dep	_	_
9	occurs	occur	VBZ	VBZ	_	0	root	_	_
10	frequently	frequently	RB	RB	_	9	advmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	multiple	multiple	JJ	JJ	_	13	amod	_	_
13	malignancies	malignancy	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	in	in	IN	IN	_	17	case	_	_
16	normal	normal	JJ	JJ	_	17	amod	_	_
17	tissues	tissue	NNS	NNS	_	13	conj	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	mimics	mimic	VBZ	VBZ	_	9	conj	_	_
20	alterations	alteration	NNS	NNS	_	19	dobj	_	_
21	previously	previously	RB	RB	_	22	advmod	_	_
22	described	describe	VBN	VBN	_	20	acl	_	_
23	in	in	IN	IN	_	24	case	_	_
24	tumours	tumour	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Intragenic	intragenic	JJ	JJ	_	2	amod	_	_
2	deletions	deletion	NNS	NNS	_	25	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TSG101	tsg101	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	homolog	homolog	NN	NN	_	4	appos	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	mouse	mouse	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	tsg101	tsg101	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	acts	act	VBZ	VBZ	_	8	acl:relcl	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	suppress	suppress	VB	VB	_	17	xcomp	_	_
20	malignant	malignant	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	growth	growth	NN	NN	_	19	dobj	_	_
23	,	,	,	,	_	2	punct	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	reported	report	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	29	case	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	breast	breast	NN	NN	_	29	compound	_	_
29	tumours	tumour	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	25	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	screened	screen	VBD	VBD	_	0	root	_	_
3	TSG101	tsg101	NN	NN	_	2	dobj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	somatic	somatic	JJ	JJ	_	6	amod	_	_
6	mutations	mutation	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	DNA	dna	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	RNA	rna	NN	NN	_	8	conj	_	_
11	samples	sample	NNS	NNS	_	8	dep	_	_
12	isolated	isolate	VBN	VBN	_	8	acl	_	_
13	from	from	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	variety	variety	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	common	common	JJ	JJ	_	19	amod	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	malignancies	malignancy	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	EBV-immortalised	ebv-immortalised	JJ	JJ	_	22	amod	_	_
22	B-cells	b-cell	NNS	NNS	_	15	conj	_	_
23	,	,	,	,	_	15	punct	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	normal	normal	JJ	JJ	_	27	amod	_	_
26	lung	lung	NN	NN	_	27	compound	_	_
27	parenchyma	parenchyma	NN	NN	_	15	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	Intragenic	intragenic	JJ	JJ	_	3	amod	_	_
2	TSG101	tsg101	NN	NN	_	3	compound	_	_
3	deletions	deletion	NNS	NNS	_	9	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	RNA	rna	NN	NN	_	6	compound	_	_
6	transcripts	transcript	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	frequently	frequently	RB	RB	_	9	advmod	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	all	all	DT	DT	_	12	det	_	_
12	types	type	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	samples	sample	NNS	NNS	_	12	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Analysis	analysis	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	DNA	dna	NN	NN	_	1	nmod	_	_
4	failed	fail	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	show	show	VB	VB	_	4	xcomp	_	_
7	genomic	genomic	JJ	JJ	_	8	amod	_	_
8	rearrangements	rearrangement	NNS	NNS	_	6	dobj	_	_
9	corresponding	correspond	VBG	VBG	_	8	acl	_	_
10	to	to	TO	TO	_	11	case	_	_
11	transcripts	transcript	NNS	NNS	_	9	nmod	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	deletions	deletion	NNS	NNS	_	12	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	same	same	JJ	JJ	_	17	amod	_	_
17	samples	sample	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	breakpoints	breakpoint	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	most	most	JJS	JJS	_	6	amod	_	_
5	transcript	transcript	NN	NN	_	6	compound	_	_
6	deletions	deletion	NNS	NNS	_	2	nmod	_	_
7	coincide	coincide	VBP	VBP	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	genuine	genuine	JJ	JJ	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	cryptic	cryptic	JJ	JJ	_	9	conj	_	_
12	splice	splice	NN	NN	_	14	compound	_	_
13	site	site	NN	NN	_	14	compound	_	_
14	sequences	sequence	NNS	NNS	_	9	dep	_	_
15	,	,	,	,	_	7	punct	_	_
16	suggesting	suggest	VBG	VBG	_	7	xcomp	_	_
17	that	that	IN	IN	_	19	mark	_	_
18	they	they	PRP	PRP	_	19	nsubj	_	_
19	result	result	VBP	VBP	_	16	ccomp	_	_
20	from	from	IN	IN	_	21	case	_	_
21	alternative	alternative	JJ	JJ	_	19	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	aberrant	aberrant	JJ	JJ	_	21	conj	_	_
24	splicing	splicing	NN	NN	_	21	dep	_	_
25	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	spectrum	spectrum	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcript	transcript	NN	NN	_	6	compound	_	_
6	deletions	deletion	NNS	NNS	_	3	nmod	_	_
7	has	have	VBZ	VBZ	_	10	aux	_	_
8	previously	previously	RB	RB	_	10	advmod	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	described	describe	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	putative	putative	JJ	JJ	_	16	amod	_	_
14	tumour	tumour	NN	NN	_	16	compound	_	_
15	suppressor	suppressor	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	10	nmod	_	_
17	FHIT	fhit	NN	NN	_	16	dep	_	_
18	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analysed	analyse	VBD	VBD	_	0	root	_	_
3	FHIT	fhit	NN	NN	_	2	dobj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	same	same	JJ	JJ	_	7	amod	_	_
7	series	series	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	RNA	rna	NN	NN	_	10	compound	_	_
10	samples	sample	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	2	cc	_	_
12	detected	detect	VBD	VBD	_	2	conj	_	_
13	truncated	truncate	VBN	VBN	_	15	amod	_	_
14	FHIT	fhit	NN	NN	_	15	compound	_	_
15	transcripts	transcript	NNS	NNS	_	12	dobj	_	_
16	frequently	frequently	RB	RB	_	12	advmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	tumour	tumour	NN	NN	_	12	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	normal	normal	JJ	JJ	_	19	conj	_	_
22	tissues	tissue	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	transcripts	transcript	NNS	NNS	_	14	nsubjpass	_	_
5	from	from	IN	IN	_	6	case	_	_
6	TSG101	tsg101	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	FHIT	fhit	NN	NN	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	seven	seven	CD	CD	_	12	nummod	_	_
11	other	other	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	6	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	analysed	analyse	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	RNA	rna	NN	NN	_	14	nmod	_	_
17	isolated	isolate	VBN	VBN	_	16	acl	_	_
18	from	from	IN	IN	_	22	case	_	_
19	normal	normal	JJ	JJ	_	22	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Large	large	JJ	JJ	_	2	amod	_	_
2	TSG101	tsg101	NN	NN	_	9	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	FHIT	fhit	NN	NN	_	2	conj	_	_
5	intragenic	intragenic	JJ	JJ	_	7	amod	_	_
6	transcript	transcript	NN	NN	_	7	compound	_	_
7	deletions	deletion	NNS	NNS	_	2	dep	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	these	these	DT	DT	_	12	nsubj	_	_
12	appeared	appear	VBD	VBD	_	9	conj	_	_
13	to	to	TO	TO	_	17	mark	_	_
14	be	be	VB	VB	_	17	cop	_	_
15	the	the	DT	DT	_	17	det	_	_
16	predominant	predominant	JJ	JJ	_	17	amod	_	_
17	transcript	transcript	NN	NN	_	12	xcomp	_	_
18	in	in	IN	IN	_	22	case	_	_
19	'	'	``	``	_	22	punct	_	_
20	aged	aged	JJ	JJ	_	22	amod	_	_
21	'	'	''	''	_	22	punct	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	alterations	alteration	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	transcripts	transcript	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	other	other	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	7	nmod	_	_
12	which	which	WDT	WDT	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	analysed	analyse	VBN	VBN	_	7	acl:relcl	_	_
15	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	truncated	truncate	VBN	VBN	_	6	amod	_	_
6	TSG101	tsg101	NN	NN	_	12	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	FHIT	fhit	NN	NN	_	6	conj	_	_
9	transcripts	transcript	NNS	NNS	_	6	dep	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	commonly	commonly	RB	RB	_	12	advmod	_	_
12	detected	detect	VBN	VBN	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	normal	normal	JJ	JJ	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	malignant	malignant	JJ	JJ	_	15	conj	_	_
18	tissues	tissue	NNS	NNS	_	15	dep	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	that	that	IN	IN	_	27	mark	_	_
21	a	a	DT	DT	_	23	det	_	_
22	significant	significant	JJ	JJ	_	23	amod	_	_
23	fraction	fraction	NN	NN	_	27	nsubj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	these	these	DT	DT	_	23	nmod	_	_
26	are	be	VBP	VBP	_	27	cop	_	_
27	likely	likely	JJ	JJ	_	12	conj	_	_
28	to	to	TO	TO	_	31	mark	_	_
29	be	be	VB	VB	_	31	cop	_	_
30	the	the	DT	DT	_	31	det	_	_
31	result	result	NN	NN	_	27	xcomp	_	_
32	of	of	IN	IN	_	34	case	_	_
33	aberrant	aberrant	JJ	JJ	_	34	amod	_	_
34	splicing	splicing	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	While	while	IN	IN	_	5	mark	_	_
2	we	we	PRP	PRP	_	5	nsubj	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	exclude	exclude	VB	VB	_	19	advcl	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	alterations	alteration	NNS	NNS	_	12	nsubj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	TSG101	tsg101	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	FHIT	fhit	NN	NN	_	9	conj	_	_
12	occur	occur	VBP	VBP	_	5	ccomp	_	_
13	during	during	IN	IN	_	15	case	_	_
14	cancer	cancer	NN	NN	_	15	compound	_	_
15	development	development	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	our	we	PRP$	PRP$	_	18	nmod:poss	_	_
18	data	datum	NNS	NNS	_	19	nsubj	_	_
19	indicate	indicate	VBP	VBP	_	0	root	_	_
20	that	that	IN	IN	_	30	mark	_	_
21	in	in	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	context	context	NN	NN	_	30	nmod	_	_
24	the	the	DT	DT	_	28	det	_	_
25	commonly	commonly	RB	RB	_	26	advmod	_	_
26	observed	observe	VBN	VBN	_	28	amod	_	_
27	transcript	transcript	NN	NN	_	28	compound	_	_
28	abnormalities	abnormality	NNS	NNS	_	30	nsubj	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	misleading	misleading	JJ	JJ	_	19	ccomp	_	_
31	.	.	.	.	_	19	punct	_	_

1	Impaired	impaired	JJ	JJ	_	3	amod	_	_
2	cortisol	cortisol	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	hypertensive	hypertensive	JJ	JJ	_	9	amod	_	_
9	patients	patient	NNS	NNS	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	compared	compare	VBD	VBD	_	0	root	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
4	receptor	receptor	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	characteristics	characteristic	NNS	NNS	_	2	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	responsiveness	responsiveness	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HML	hml	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	from	from	IN	IN	_	19	case	_	_
18	hypertensive	hypertensive	JJ	JJ	_	19	amod	_	_
19	patients	patient	NNS	NNS	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	matched	match	VBD	VBD	_	23	amod	_	_
22	normotensive	normotensive	JJ	JJ	_	23	amod	_	_
23	volunteers	volunteer	NNS	NNS	_	19	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	considered	consider	VBD	VBD	_	0	root	_	_
4	associations	association	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	variables	variable	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	plasma	plasma	NN	NN	_	11	compound	_	_
10	renin	renin	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	aldosterone	aldosterone	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	13	punct	_	_
15	cortisol	cortisol	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	corticotropin	corticotropin	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	electrolyte	electrolyte	NN	NN	_	13	conj	_	_
21	concentrations	concentration	NNS	NNS	_	13	dep	_	_
22	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	calculated	calculate	VBD	VBD	_	0	root	_	_
3	binding	binding	NN	NN	_	2	dobj	_	_
4	affinity	affinity	NN	NN	_	3	dep	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Kd	kd	NN	NN	_	4	dep	_	_
7	;	;	:	:	_	6	punct	_	_
8	nmol/L	nmol/l	NN	NN	_	6	dep	_	_
9	)	)	-RRB-	-RRB-	_	6	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	capacity	capacity	NN	NN	_	3	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Bmax	bmax	NN	NN	_	11	dep	_	_
14	;	;	:	:	_	13	punct	_	_
15	sites/cell	sites/cell	NNS	NNS	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	13	punct	_	_
17	for	for	IN	IN	_	18	case	_	_
18	dexamethasone	dexamethasone	NN	NN	_	3	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cortisol	cortisol	NN	NN	_	18	conj	_	_
21	from	from	IN	IN	_	22	case	_	_
22	homologous	homologous	JJ	JJ	_	2	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	heterologous	heterologous	JJ	JJ	_	22	conj	_	_
25	competition	competition	NN	NN	_	26	compound	_	_
26	curves	curve	NNS	NNS	_	22	dep	_	_
27	for	for	IN	IN	_	31	case	_	_
28	specific	specific	JJ	JJ	_	31	amod	_	_
29	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	22	nmod	_	_
32	on	on	IN	IN	_	33	case	_	_
33	HML	hml	NN	NN	_	31	nmod	_	_
34	isolated	isolate	VBN	VBN	_	33	acl	_	_
35	from	from	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	blood	blood	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	normotensive	normotensive	JJ	JJ	_	40	amod	_	_
40	volunteers	volunteer	NNS	NNS	_	37	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	subjects	subject	NNS	NNS	_	40	conj	_	_
43	with	with	IN	IN	_	45	case	_	_
44	essential	essential	JJ	JJ	_	45	amod	_	_
45	hypertension	hypertension	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	responsiveness	responsiveness	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HML	hml	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	evaluated	evaluate	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	9	case	_	_
8	IC50	ic50	NN	NN	_	9	compound	_	_
9	values	value	NNS	NNS	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	nmol/L	nmol/l	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	for	for	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cortisol	cortisol	NN	NN	_	14	conj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	inhibition	inhibition	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	lysozyme	lysozyme	NN	NN	_	22	compound	_	_
22	release	release	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	measured	measure	VBD	VBD	_	0	root	_	_
3	plasma	plasma	NN	NN	_	4	compound	_	_
4	hormones	hormone	NNS	NNS	_	2	dobj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	radioimmunoassay	radioimmunoassay	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	Kd	kd	NN	NN	_	2	compound	_	_
2	values	value	NNS	NNS	_	14	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	mean+/-SE	mean+/-se	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	for	for	IN	IN	_	7	case	_	_
7	cortisol	cortisol	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	HML	hml	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	hypertensive	hypertensive	JJ	JJ	_	12	amod	_	_
12	patients	patient	NNS	NNS	_	9	nmod	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	higher	higher	JJR	JJR	_	0	root	_	_
15	than	than	IN	IN	_	18	case	_	_
16	in	in	IN	IN	_	18	case	_	_
17	control	control	NN	NN	_	18	compound	_	_
18	subjects	subject	NNS	NNS	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	24.6+/-2.4	24.6+/-2.4	CD	CD	_	14	dep	_	_
21	versus	versus	CC	CC	_	20	cc	_	_
22	17.5+/-1.7	17.5+/-1.7	CD	CD	_	20	conj	_	_
23	nmol/L	nmol/l	NN	NN	_	20	dep	_	_
24	,	,	,	,	_	20	punct	_	_
25	P	p	NN	NN	_	20	appos	_	_
26	&lt;	&lt;	JJR	JJR	_	25	amod	_	_
27	.04	.04	CD	CD	_	26	dep	_	_
28	)	)	-RRB-	-RRB-	_	20	punct	_	_
29	.	.	.	.	_	14	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	capacity	capacity	NN	NN	_	43	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	4978+/-391	4978+/-391	CD	CD	_	2	dep	_	_
5	versus	versus	CC	CC	_	4	cc	_	_
6	4131+/-321	4131+/-321	CD	CD	_	4	conj	_	_
7	sites/cell	sites/cell	NNS	NNS	_	4	dep	_	_
8	)	)	-RRB-	-RRB-	_	4	punct	_	_
9	,	,	,	,	_	2	punct	_	_
10	Kd	kd	NN	NN	_	11	compound	_	_
11	values	value	NNS	NNS	_	2	conj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	dexamethasone	dexamethasone	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	6.7+/-0.5	6.7+/-0.5	CD	CD	_	11	dep	_	_
16	versus	versus	CC	CC	_	15	cc	_	_
17	5.7+/-0.3	5.7+/-0.3	CD	CD	_	15	conj	_	_
18	nmol/L	nmol/l	NN	NN	_	15	dep	_	_
19	)	)	-RRB-	-RRB-	_	15	punct	_	_
20	,	,	,	,	_	2	punct	_	_
21	and	and	CC	CC	_	2	cc	_	_
22	IC50	ic50	NN	NN	_	23	compound	_	_
23	values	value	NNS	NNS	_	2	conj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	dexamethasone	dexamethasone	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	3.4+/-0.3	3.4+/-0.3	CD	CD	_	25	dep	_	_
28	versus	versus	CC	CC	_	27	cc	_	_
29	3.1+/-0.2	3.1+/-0.2	CD	CD	_	27	conj	_	_
30	nmol/L	nmol/l	NN	NN	_	27	dep	_	_
31	)	)	-RRB-	-RRB-	_	27	punct	_	_
32	and	and	CC	CC	_	25	cc	_	_
33	cortisol	cortisol	NN	NN	_	25	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	12.2+/-1.6	12.2+/-1.6	CD	CD	_	33	dep	_	_
36	versus	versus	CC	CC	_	35	cc	_	_
37	9.5+/-0.3	9.5+/-0.3	CD	CD	_	35	conj	_	_
38	nmol/L	nmol/l	NN	NN	_	35	dep	_	_
39	)	)	-RRB-	-RRB-	_	35	punct	_	_
40	were	be	VBD	VBD	_	43	cop	_	_
41	not	not	RB	RB	_	43	neg	_	_
42	significantly	significantly	RB	RB	_	43	advmod	_	_
43	different	different	JJ	JJ	_	0	root	_	_
44	.	.	.	.	_	43	punct	_	_

1	Patients	patient	NNS	NNS	_	16	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	renin	renin	NN	NN	_	4	compound	_	_
4	values	value	NNS	NNS	_	1	nmod	_	_
5	less	less	JJR	JJR	_	4	amod	_	_
6	than	than	IN	IN	_	10	case	_	_
7	0.13	0.13	CD	CD	_	8	compound	_	_
8	ng	ng	NN	NN	_	10	amod	_	_
9	angiotensin	angiotensin	NN	NN	_	10	compound	_	_
10	I/L	i/l	NN	NN	_	5	nmod	_	_
11	per	per	IN	IN	_	12	case	_	_
12	second	second	NN	NN	_	10	nmod	_	_
13	were	be	VBD	VBD	_	16	cop	_	_
14	markedly	markedly	RB	RB	_	15	advmod	_	_
15	less	less	RBR	RBR	_	16	advmod	_	_
16	sensitive	sensitive	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	case	_	_
18	cortisol	cortisol	NN	NN	_	16	nmod	_	_
19	than	than	IN	IN	_	20	case	_	_
20	those	those	DT	DT	_	16	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	higher	higher	JJR	JJR	_	23	amod	_	_
23	values	value	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	16	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	Kd	kd	NN	NN	_	22	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	30.3+/-2.5	30.3+/-2.5	CD	CD	_	2	dep	_	_
5	versus	versus	CC	CC	_	4	cc	_	_
6	19.2+/-2.4	19.2+/-2.4	CD	CD	_	4	conj	_	_
7	nmol/L	nmol/l	NN	NN	_	4	dep	_	_
8	)	)	-RRB-	-RRB-	_	4	punct	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	IC50	ic50	NN	NN	_	11	compound	_	_
11	values	value	NNS	NNS	_	2	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	15.5+/-1.8	15.5+/-1.8	CD	CD	_	11	dep	_	_
14	versus	versus	CC	CC	_	13	cc	_	_
15	8.9+/-1.2	8.9+/-1.2	CD	CD	_	13	conj	_	_
16	nmol/L	nmol/l	NN	NN	_	13	dep	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	for	for	IN	IN	_	19	case	_	_
19	cortisol	cortisol	NN	NN	_	2	nmod	_	_
20	were	be	VBD	VBD	_	22	cop	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	higher	higher	JJR	JJR	_	0	root	_	_
23	in	in	IN	IN	_	24	case	_	_
24	patients	patient	NNS	NNS	_	22	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	lower	lower	JJR	JJR	_	28	amod	_	_
27	renin	renin	NN	NN	_	28	compound	_	_
28	values	value	NNS	NNS	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	P	p	NN	NN	_	28	dep	_	_
31	&lt;	&lt;	JJR	JJR	_	30	amod	_	_
32	.03	.03	CD	CD	_	31	dep	_	_
33	)	)	-RRB-	-RRB-	_	30	punct	_	_
34	.	.	.	.	_	22	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	variables	variable	NNS	NNS	_	18	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	including	include	VBG	VBG	_	6	case	_	_
5	plasma	plasma	NN	NN	_	6	compound	_	_
6	hormone	hormone	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	electrolyte	electrolyte	NN	NN	_	6	conj	_	_
9	values	value	NNS	NNS	_	6	dep	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	characteristics	characteristic	NNS	NNS	_	6	conj	_	_
13	for	for	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	were	be	VBD	VBD	_	18	cop	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	different	different	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	cortisol	cortisol	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	12	nsubj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	slightly	slightly	RB	RB	_	12	advmod	_	_
12	impaired	impaired	JJ	JJ	_	3	ccomp	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	essential	essential	JJ	JJ	_	17	amod	_	_
17	hypertension	hypertension	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vivo	vivo	FW	FW	_	6	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	this	this	DT	DT	_	6	nsubj	_	_
5	could	could	MD	MD	_	6	aux	_	_
6	lead	lead	VB	VB	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	inappropriate	inappropriate	JJ	JJ	_	9	amod	_	_
9	binding	binding	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cortisol	cortisol	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	mineralocorticoid	mineralocorticoid	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Hence	hence	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	decreased	decrease	VBN	VBN	_	4	amod	_	_
4	sensitivity	sensitivity	NN	NN	_	8	nsubjpass	_	_
5	to	to	TO	TO	_	6	case	_	_
6	cortisol	cortisol	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	renin	renin	NN	NN	_	11	compound	_	_
11	suppression	suppression	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	hypothesis	hypothesis	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	supported	support	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	evidence	evidence	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	hypertension	hypertension	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	low	low	JJ	JJ	_	12	amod	_	_
11	renin	renin	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	which	which	WDT	WDT	_	17	dobj	_	_
15	others	other	NNS	NNS	_	17	nsubj	_	_
16	have	have	VBP	VBP	_	17	aux	_	_
17	described	describe	VBN	VBN	_	8	acl:relcl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	primary	primary	JJ	JJ	_	23	amod	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	resistance	resistance	NN	NN	_	19	nmod	_	_
24	due	due	JJ	JJ	_	23	amod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	mutations	mutation	NNS	NNS	_	24	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	glucocorticoid	glucocorticoid	NN	NN	_	30	compound	_	_
30	receptor	receptor	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Repression	repression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	type	type	NN	NN	_	1	nmod	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	through	through	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	novel	novel	JJ	JJ	_	11	amod	_	_
11	cooperation	cooperation	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	YY1	yy1	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	LSF	lsf	NN	NN	_	15	conj	_	_
18	-LSB-	-lsb-	-LRB-	-LRB-	_	21	punct	_	_
19	published	publish	VBN	VBN	_	20	amod	_	_
20	erratum	erratum	NN	NN	_	21	nsubj	_	_
21	appears	appear	VBZ	VBZ	_	1	dep	_	_
22	in	in	IN	IN	_	24	case	_	_
23	J	J	NNP	NNP	_	24	compound	_	_
24	Virol	Virol	NNP	NNP	_	21	nmod	_	_
25	1998	1998	CD	CD	_	26	nummod	_	_
26	Feb	Feb	NNP	NNP	_	24	dep	_	_
27	;	;	:	:	_	24	punct	_	_
28	72	72	CD	CD	_	30	nummod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	2	2	CD	CD	_	24	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	:	:	:	:	_	24	punct	_	_
33	1709	1709	CD	CD	_	24	dep	_	_
34	-RSB-	-rsb-	-RRB-	-RRB-	_	21	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	subpopulation	subpopulation	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	stably	stably	RB	RB	_	7	advmod	_	_
5	infected	infected	JJ	JJ	_	7	amod	_	_
6	CD4+	cd4+	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	capable	capable	JJ	JJ	_	2	amod	_	_
9	of	of	IN	IN	_	10	mark	_	_
10	producing	produce	VBG	VBG	_	8	advcl	_	_
11	virus	virus	NN	NN	_	10	dobj	_	_
12	upon	upon	IN	IN	_	13	case	_	_
13	stimulation	stimulation	NN	NN	_	10	nmod	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	identified	identify	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	25	case	_	_
18	human	human	JJ	JJ	_	25	amod	_	_
19	immunodeficiency	immunodeficiency	NN	NN	_	25	compound	_	_
20	virus	virus	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	HIV	hiv	NN	NN	_	25	compound	_	_
23	)	)	-RRB-	-RRB-	_	25	punct	_	_
24	-positive	-positive	JJ	JJ	_	25	amod	_	_
25	individuals	individual	NNS	NNS	_	16	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	T.-W.Chun	T.-W.Chun	NNP	NNP	_	16	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	D.Finzi	D.Finzi	NNP	NNP	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	J.Margolick	J.Margolick	NNP	NNP	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	K.Chadwick	K.Chadwick	NNP	NNP	_	27	conj	_	_
34	,	,	,	,	_	27	punct	_	_
35	D.Schwartz	D.Schwartz	NNP	NNP	_	27	conj	_	_
36	,	,	,	,	_	27	punct	_	_
37	and	and	CC	CC	_	27	cc	_	_
38	R.F.Siliciano	R.F.Siliciano	NNP	NNP	_	27	conj	_	_
39	,	,	,	,	_	27	punct	_	_
40	Nat.Med.1	Nat.Med.1	NNP	NNP	_	27	appos	_	_
41	:	:	:	:	_	27	punct	_	_
42	1284-1290	1284-1290	CD	CD	_	27	dep	_	_
43	,	,	,	,	_	27	punct	_	_
44	1995	1995	CD	CD	_	27	amod	_	_
45	)	)	-RRB-	-RRB-	_	27	punct	_	_
46	.	.	.	.	_	16	punct	_	_

1	Few	few	JJ	JJ	_	3	amod	_	_
2	host	host	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	20	nsubjpass	_	_
4	that	that	WDT	WDT	_	6	nsubj	_	_
5	directly	directly	RB	RB	_	6	advmod	_	_
6	limit	limit	VBP	VBP	_	3	acl:relcl	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	could	could	MD	MD	_	11	aux	_	_
11	support	support	VB	VB	_	6	conj	_	_
12	this	this	DT	DT	_	13	det	_	_
13	state	state	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	nonproductive	nonproductive	JJ	JJ	_	17	amod	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	infection	infection	NN	NN	_	13	nmod	_	_
18	have	have	VBP	VBP	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	described	describe	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	YY1	yy1	NN	NN	_	11	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	8	det	_	_
4	widely	widely	RB	RB	_	5	advmod	_	_
5	distributed	distribute	VBN	VBN	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	1	appos	_	_
9	,	,	,	,	_	1	punct	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	known	know	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	inhibit	inhibit	VB	VB	_	11	xcomp	_	_
14	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	LTR	ltr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	transcription	transcription	NN	NN	_	13	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	virus	virus	NN	NN	_	24	compound	_	_
24	production	production	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	LSF	lsf	NN	NN	_	15	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	known	know	VBN	VBN	_	1	dep	_	_
5	as	as	IN	IN	_	6	case	_	_
6	LBP-1	lbp-1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	UBP	ubp	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	CP-2	cp-2	NN	NN	_	6	conj	_	_
12	)	)	-RRB-	-RRB-	_	4	punct	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	repress	repress	VB	VB	_	15	xcomp	_	_
18	LTR	ltr	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	17	dobj	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vitro	vitro	FW	FW	_	17	advmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	but	but	CC	CC	_	15	cc	_	_
24	transient	transient	JJ	JJ	_	25	amod	_	_
25	expression	expression	NN	NN	_	28	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	LSF	lsf	NN	NN	_	25	nmod	_	_
28	has	have	VBZ	VBZ	_	15	conj	_	_
29	no	no	DT	DT	_	30	neg	_	_
30	effect	effect	NN	NN	_	28	dobj	_	_
31	on	on	IN	IN	_	33	case	_	_
32	LTR	ltr	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	28	nmod	_	_
34	in	in	FW	FW	_	35	compound	_	_
35	vivo	vivo	FW	FW	_	28	advmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	YY1	yy1	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	LSF	lsf	NN	NN	_	5	conj	_	_
8	participate	participate	VBP	VBP	_	2	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	formation	formation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	complex	complex	NN	NN	_	11	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	recognizes	recognize	VBZ	VBZ	_	14	acl:relcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	initiation	initiation	NN	NN	_	19	compound	_	_
19	region	region	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	HIV-1	hiv-1	NN	NN	_	23	compound	_	_
23	LTR	ltr	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Further	further	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	these	these	DT	DT	_	8	det	_	_
8	factors	factor	NNS	NNS	_	9	nsubj	_	_
9	cooperate	cooperate	VBP	VBP	_	5	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	repression	repression	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	LTR	ltr	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	replication	replication	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cooperative	cooperative	JJ	JJ	_	3	amod	_	_
3	function	function	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	account	account	VB	VB	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	divergent	divergent	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	LSF	lsf	NN	NN	_	9	nmod	_	_
12	previously	previously	RB	RB	_	13	advmod	_	_
13	observed	observe	VBN	VBN	_	9	acl	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	13	advmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	in	in	FW	FW	_	15	conj	_	_
18	vivo	vivo	FW	FW	_	17	dep	_	_
19	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cooperation	cooperation	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	two	two	CD	CD	_	10	nummod	_	_
7	general	general	JJ	JJ	_	10	amod	_	_
8	cellular	cellular	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	4	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	allow	allow	VB	VB	_	0	root	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	selective	selective	JJ	JJ	_	16	amod	_	_
16	downregulation	downregulation	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Through	through	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	mechanism	mechanism	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	regulation	regulation	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	YY1	yy1	NN	NN	_	12	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	LSF	lsf	NN	NN	_	8	conj	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	contribute	contribute	VB	VB	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	establishment	establishment	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	maintenance	maintenance	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	population	population	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	cells	cell	NNS	NNS	_	20	nmod	_	_
23	stably	stably	RB	RB	_	24	advmod	_	_
24	but	but	CC	CC	_	26	advmod	_	_
25	nonproductively	nonproductively	RB	RB	_	24	advmod	_	_
26	infected	infect	VBN	VBN	_	20	acl	_	_
27	with	with	IN	IN	_	28	case	_	_
28	HIV-1	hiv-1	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Ras-related	ras-related	JJ	JJ	_	3	amod	_	_
2	GTP-binding	gtp-binding	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	leukocyte	leukocyte	NN	NN	_	7	compound	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transduction	transduction	NN	NN	_	3	conj	_	_
8	.	.	.	.	_	3	punct	_	_

1	Many	many	JJ	JJ	_	2	amod	_	_
2	aspects	aspect	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	leukocyte	leukocyte	NN	NN	_	5	compound	_	_
5	function	function	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	regulated	regulate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	heterotrimeric	heterotrimeric	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Ras-related	ras-related	JJ	JJ	_	14	amod	_	_
13	GTP-binding	gtp-binding	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	10	conj	_	_
15	,	,	,	,	_	7	punct	_	_
16	but	but	CC	CC	_	7	cc	_	_
17	there	there	EX	EX	_	18	expl	_	_
18	is	be	VBZ	VBZ	_	7	conj	_	_
19	little	little	JJ	JJ	_	21	amod	_	_
20	definite	definite	JJ	JJ	_	19	dep	_	_
21	information	information	NN	NN	_	18	nsubj	_	_
22	about	about	IN	IN	_	24	case	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	roles	role	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	specialized	specialized	JJ	JJ	_	28	amod	_	_
28	processes	process	NNS	NNS	_	24	nmod	_	_
29	utilized	utilize	VBN	VBN	_	24	acl	_	_
30	by	by	IN	IN	_	31	case	_	_
31	leukocytes	leukocyte	NNS	NNS	_	29	nmod	_	_
32	for	for	IN	IN	_	34	case	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	killing	killing	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	progress	progress	NN	NN	_	17	nsubj	_	_
3	in	in	IN	IN	_	4	mark	_	_
4	understanding	understand	VBG	VBG	_	2	acl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	regulation	regulation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	phagocyte	phagocyte	NN	NN	_	11	compound	_	_
10	NADPH	nadph	NN	NN	_	11	compound	_	_
11	oxidase	oxidase	NN	NN	_	6	nmod	_	_
12	by	by	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	Rac	rac	NN	NN	_	16	compound	_	_
15	GTP-binding	gtp-binding	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	6	nmod	_	_
17	provides	provide	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	19	det	_	_
19	basis	basis	NN	NN	_	17	dobj	_	_
20	for	for	IN	IN	_	21	mark	_	_
21	defining	define	VBG	VBG	_	19	acl	_	_
22	the	the	DT	DT	_	24	det	_	_
23	operational	operational	JJ	JJ	_	24	amod	_	_
24	characteristics	characteristic	NNS	NNS	_	21	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	one	one	CD	CD	_	29	nummod	_	_
27	such	such	JJ	JJ	_	29	amod	_	_
28	phagocyte	phagocyte	NN	NN	_	29	compound	_	_
29	system	system	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	clear	clear	JJ	JJ	_	0	root	_	_
4	from	from	IN	IN	_	6	case	_	_
5	various	various	JJ	JJ	_	6	amod	_	_
6	studies	study	NNS	NNS	_	3	nmod	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activity	activity	NN	NN	_	16	nsubjpass	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	NADPH	nadph	NN	NN	_	13	compound	_	_
13	oxidase	oxidase	NN	NN	_	9	nmod	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	modulated	modulate	VBN	VBN	_	3	ccomp	_	_
17	through	through	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	GTP-GDP	gtp-gdp	JJ	JJ	_	23	amod	_	_
23	state	state	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	Rac	rac	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Proteins	protein	NNS	NNS	_	2	nsubj	_	_
2	exist	exist	VBP	VBP	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
5	able	able	JJ	JJ	_	2	dep	_	_
6	to	to	TO	TO	_	5	dep	_	_
7	modify	modify	VB	VB	_	6	ccomp	_	_
8	GTP-binding	gtp-binding	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	function	function	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	manner	manner	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	activity	activity	NN	NN	_	20	nsubjpass	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	regulated	regulate	VBN	VBN	_	2	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	signals	signal	NNS	NNS	_	20	nmod	_	_
23	generated	generate	VBN	VBN	_	22	acl	_	_
24	on	on	IN	IN	_	26	case	_	_
25	phagocyte	phagocyte	NN	NN	_	26	compound	_	_
26	stimulation	stimulation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Proteins	protein	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Ras	ras	NN	NN	_	5	compound	_	_
5	superfamily	superfamily	NN	NN	_	1	nmod	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	likely	likely	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	7	xcomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	variety	variety	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	phagocyte	phagocyte	NN	NN	_	17	compound	_	_
17	functions	function	NNS	NNS	_	13	nmod	_	_
18	through	through	IN	IN	_	20	case	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	ability	ability	NN	NN	_	10	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	modulate	modulate	VB	VB	_	20	acl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	assembly	assembly	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	actin	actin	NN	NN	_	27	compound	_	_
27	filaments	filament	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	direct	direct	JJ	JJ	_	30	amod	_	_
30	vesicle	vesicle	NN	NN	_	24	conj	_	_
31	trafficking	trafficking	NN	NN	_	30	dep	_	_
32	and	and	CC	CC	_	30	cc	_	_
33	fusion	fusion	NN	NN	_	30	conj	_	_
34	,	,	,	,	_	24	punct	_	_
35	and	and	CC	CC	_	24	cc	_	_
36	so	so	RB	RB	_	37	advmod	_	_
37	forth	forth	RB	RB	_	24	advmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	OCA-B	oca-b	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	analog	analog	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	VP16	vp16	NN	NN	_	5	nmod	_	_
8	but	but	CC	CC	_	5	cc	_	_
9	targets	target	VBZ	VBZ	_	5	conj	_	_
10	a	a	DT	DT	_	12	det	_	_
11	separate	separate	JJ	JJ	_	12	amod	_	_
12	surface	surface	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	Oct-1	oct-1	NN	NN	_	17	compound	_	_
16	POU	pou	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	12	nmod	_	_
18	-LSB-	-lsb-	-LRB-	-LRB-	_	21	punct	_	_
19	published	publish	VBN	VBN	_	20	amod	_	_
20	erratum	erratum	NN	NN	_	21	nsubj	_	_
21	appears	appear	VBZ	VBZ	_	5	parataxis	_	_
22	in	in	IN	IN	_	25	case	_	_
23	Mol	Mol	NNP	NNP	_	25	compound	_	_
24	Cell	Cell	NNP	NNP	_	25	compound	_	_
25	Biol	Biol	NNP	NNP	_	21	nmod	_	_
26	1998	1998	CD	CD	_	27	nummod	_	_
27	Apr	Apr	NNP	NNP	_	25	dep	_	_
28	;	;	:	:	_	25	punct	_	_
29	18	18	CD	CD	_	31	nummod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	4	4	CD	CD	_	25	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	:	:	:	:	_	25	punct	_	_
34	2430	2430	CD	CD	_	25	dep	_	_
35	-RSB-	-rsb-	-RRB-	-RRB-	_	21	punct	_	_

1	OCA-B	oca-b	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	B-cell-specific	b-cell-specific	JJ	JJ	_	5	amod	_	_
5	coregulator	coregulator	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	broadly	broadly	RB	RB	_	9	advmod	_	_
9	expressed	express	VBN	VBN	_	13	amod	_	_
10	POU	pou	NN	NN	_	13	compound	_	_
11	domain	domain	NN	NN	_	13	compound	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	5	nmod	_	_
14	Oct-1	oct-1	NN	NN	_	13	dep	_	_
15	.	.	.	.	_	5	punct	_	_

1	OCA-B	oca-b	NN	NN	_	2	nsubj	_	_
2	associates	associate	VBZ	VBZ	_	0	root	_	_
3	with	with	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	Oct-1	oct-1	NN	NN	_	7	compound	_	_
6	POU	pou	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	12	det	_	_
10	bipartite	bipartite	JJ	JJ	_	12	amod	_	_
11	DNA-binding	dna-binding	JJ	JJ	_	10	dep	_	_
12	structure	structure	NN	NN	_	7	appos	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	a	a	DT	DT	_	19	det	_	_
15	POU-specific	pou-specific	JJ	JJ	_	19	amod	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	POU-LSB-S-RSB-	pou-lsb-s-rsb-	JJ	JJ	_	19	amod	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	domain	domain	NN	NN	_	13	dobj	_	_
20	joined	join	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	flexible	flexible	JJ	JJ	_	24	amod	_	_
24	linker	linker	NN	NN	_	20	nmod	_	_
25	to	to	TO	TO	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	POU	pou	NN	NN	_	28	compound	_	_
28	homeodomain	homeodomain	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	POU-LSB-H-RSB-	pou-lsb-h-rsb-	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	OCA-B	oca-b	NN	NN	_	7	nsubj	_	_
7	alters	alter	VBZ	VBZ	_	4	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Oct-1	oct-1	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	ways	way	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	provides	provide	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	2	dobj	_	_
7	which	which	WDT	WDT	_	12	nsubj	_	_
8	,	,	,	,	_	12	punct	_	_
9	unlike	unlike	IN	IN	_	10	case	_	_
10	Oct-1	oct-1	NN	NN	_	12	nmod	_	_
11	,	,	,	,	_	12	punct	_	_
12	activates	activate	VBZ	VBZ	_	6	acl:relcl	_	_
13	an	a	DT	DT	_	15	det	_	_
14	mRNA-type	mrna-type	JJ	JJ	_	15	amod	_	_
15	promoter	promoter	NN	NN	_	12	dobj	_	_
16	effectively	effectively	RB	RB	_	12	advmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	and	and	CC	CC	_	2	cc	_	_
19	it	it	PRP	PRP	_	20	nsubj	_	_
20	stabilizes	stabilize	VBZ	VBZ	_	2	conj	_	_
21	Oct-1	oct-1	NN	NN	_	20	dobj	_	_
22	on	on	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	Oct-1-responsive	oct-1-responsive	JJ	JJ	_	26	amod	_	_
25	octamer	octamer	NN	NN	_	26	compound	_	_
26	sequence	sequence	NN	NN	_	20	nmod	_	_
27	ATGCAAAT	atgcaaat	NN	NN	_	26	dep	_	_
28	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	properties	property	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	OCA-B	oca-b	NN	NN	_	2	nmod	_	_
5	parallel	parallel	VBP	VBP	_	0	root	_	_
6	those	those	DT	DT	_	5	dobj	_	_
7	displayed	display	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	herpes	herpes	NN	NN	_	14	compound	_	_
11	simplex	simplex	JJ	JJ	_	14	amod	_	_
12	virus	virus	NN	NN	_	14	compound	_	_
13	Oct-1	oct-1	NN	NN	_	14	compound	_	_
14	coregulator	coregulator	NN	NN	_	7	nmod	_	_
15	VP16	vp16	NN	NN	_	14	dep	_	_
16	.	.	.	.	_	5	punct	_	_

1	OCA-B	oca-b	NN	NN	_	5	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	however	however	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	interacts	interact	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	surface	surface	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	DNA-bound	dna-bound	JJ	JJ	_	15	amod	_	_
13	Oct-1	oct-1	NN	NN	_	15	compound	_	_
14	POU	pou	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	interacting	interact	VBG	VBG	_	5	xcomp	_	_
18	with	with	IN	IN	_	24	case	_	_
19	both	both	CC	CC	_	24	cc:preconj	_	_
20	the	the	DT	DT	_	24	det	_	_
21	POU(S)	pou(s)	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	POU(H)	pou(h)	NN	NN	_	21	conj	_	_
24	domains	domain	NNS	NNS	_	17	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	27	det	_	_
27	center	center	NN	NN	_	24	conj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	ATGCAAAT	atgcaaat	NN	NN	_	32	compound	_	_
31	octamer	octamer	NN	NN	_	32	compound	_	_
32	sequence	sequence	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	OCA-B	oca-b	NN	NN	_	13	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	VP16	vp16	NN	NN	_	2	conj	_	_
5	interactions	interaction	NNS	NNS	_	2	dep	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	Oct-1	oct-1	NN	NN	_	10	compound	_	_
9	POU	pou	NN	NN	_	10	compound	_	_
10	domain	domain	NN	NN	_	2	nmod	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	sufficiently	sufficiently	RB	RB	_	13	advmod	_	_
13	different	different	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	permit	permit	VB	VB	_	13	xcomp	_	_
16	OCA-B	oca-b	NN	NN	_	15	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	VP16	vp16	NN	NN	_	16	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	bind	bind	VB	VB	_	15	xcomp	_	_
21	the	the	DT	DT	_	24	det	_	_
22	Oct-1	oct-1	NN	NN	_	24	compound	_	_
23	POU	pou	NN	NN	_	24	compound	_	_
24	domain	domain	NN	NN	_	20	dobj	_	_
25	simultaneously	simultaneously	RB	RB	_	20	advmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	emphasize	emphasize	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	structural	structural	JJ	JJ	_	6	amod	_	_
6	versatility	versatility	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	Oct-1	oct-1	NN	NN	_	11	compound	_	_
10	POU	pou	NN	NN	_	11	compound	_	_
11	domain	domain	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	interaction	interaction	NN	NN	_	6	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	coregulators	coregulator	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Extinction	extinction	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	immunoglobulin	immunoglobulin	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	upon	upon	IN	IN	_	10	case	_	_
10	fusion	fusion	NN	NN	_	1	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	HeLa	hela	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	preceded	precede	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	rapid	rapid	JJ	JJ	_	19	amod	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	depletion	depletion	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	essential	essential	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	accompanied	accompany	VBN	VBN	_	15	conj	_	_
27	by	by	IN	IN	_	29	case	_	_
28	widespread	widespread	JJ	JJ	_	29	amod	_	_
29	inactivation	inactivation	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	genes	gene	NNS	NNS	_	29	nmod	_	_
32	expressed	express	VBN	VBN	_	31	acl	_	_
33	in	in	IN	IN	_	37	case	_	_
34	a	a	DT	DT	_	37	det	_	_
35	B	b	NN	NN	_	37	compound	_	_
36	cell-specific	cell-specific	JJ	JJ	_	37	amod	_	_
37	manner	manner	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	When	when	WRB	WRB	_	10	advmod	_	_
2	immunoglobulin	immunoglobulin	NN	NN	_	8	compound	_	_
3	(	(	-LRB-	-LRB-	_	8	punct	_	_
4	Ig	ig	NN	NN	_	8	compound	_	_
5	)	)	-RRB-	-RRB-	_	8	punct	_	_
6	expressing	expressing	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	fused	fuse	VBN	VBN	_	19	advcl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	non-B	non-b	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	19	punct	_	_
15	Ig	ig	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	19	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	19	auxpass	_	_
18	rapidly	rapidly	RB	RB	_	19	advmod	_	_
19	suppressed	suppress	VBN	VBN	_	0	root	_	_
20	at	at	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	level	level	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	transcription	transcription	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	a	a	DT	DT	_	27	det	_	_
27	phenomenon	phenomenon	NN	NN	_	19	dep	_	_
28	termed	term	VBN	VBN	_	27	acl	_	_
29	extinction	extinction	NN	NN	_	28	xcomp	_	_
30	.	.	.	.	_	19	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	fusion	fusion	NN	NN	_	19	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	HeLa	hela	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	either	either	CC	CC	_	11	cc:preconj	_	_
11	diploid	diploid	JJ	JJ	_	5	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	tetraploid	tetraploid	JJ	JJ	_	11	conj	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	dep	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Daudi	daudi	NN	NN	_	11	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	results	result	VBZ	VBZ	_	3	ccomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	widespread	widespread	JJ	JJ	_	22	amod	_	_
22	extinction	extinction	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	several	several	JJ	JJ	_	25	amod	_	_
25	other	other	JJ	JJ	_	28	amod	_	_
26	B	b	NN	NN	_	28	compound	_	_
27	cell-encoded	cell-encoded	JJ	JJ	_	28	amod	_	_
28	genes	gene	NNS	NNS	_	22	nmod	_	_
29	that	that	WDT	WDT	_	31	nsubjpass	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	expressed	express	VBN	VBN	_	28	acl:relcl	_	_
32	in	in	IN	IN	_	36	case	_	_
33	a	a	DT	DT	_	36	det	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	cell-specific	cell-specific	JJ	JJ	_	36	amod	_	_
36	manner	manner	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	expression	expression	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	cell-expressed	cell-expressed	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	4	nmod	_	_
9	that	that	WDT	WDT	_	12	nsubj	_	_
10	are	be	VBP	VBP	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	dependent	dependent	JJ	JJ	_	8	acl:relcl	_	_
13	on	on	IN	IN	_	15	case	_	_
14	cell-specific	cell-specific	JJ	JJ	_	15	amod	_	_
15	controls	control	NNS	NNS	_	12	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	unaffected	unaffected	JJ	JJ	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	molecular	molecular	JJ	JJ	_	8	amod	_	_
6	mechanism	mechanism	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	16	nsubjpass	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	underlying	underlie	VBG	VBG	_	8	acl	_	_
11	Ig	ig	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	extinction	extinction	NN	NN	_	10	dobj	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	explained	explain	VBN	VBN	_	2	ccomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	at	at	IN	IN	_	21	advmod	_	_
19	least	least	JJS	JJS	_	18	mwe	_	_
20	in	in	IN	IN	_	21	case	_	_
21	part	part	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	by	by	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	lack	lack	NN	NN	_	16	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	that	that	WDT	WDT	_	31	nsubj	_	_
30	are	be	VBP	VBP	_	31	cop	_	_
31	essential	essential	JJ	JJ	_	28	acl:relcl	_	_
32	for	for	IN	IN	_	35	case	_	_
33	Ig	ig	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	transcription	transcription	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	are	be	VBP	VBP	_	0	root	_	_
5	either	either	CC	CC	_	4	dep	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	produced	produce	VBN	VBN	_	4	conj	_	_
8	due	due	JJ	JJ	_	7	xcomp	_	_
9	to	to	TO	TO	_	10	case	_	_
10	block	block	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	transcription	transcription	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
15	respective	respective	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Oct-2	oct-2	NN	NN	_	16	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	OBF-1	obf-1	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	18	punct	_	_
22	PU.1	pu.1	NN	NN	_	18	appos	_	_
23	)	)	-RRB-	-RRB-	_	18	punct	_	_
24	,	,	,	,	_	4	punct	_	_
25	or	or	CC	CC	_	4	cc	_	_
26	are	be	VBP	VBP	_	27	auxpass	_	_
27	rendered	render	VBN	VBN	_	4	conj	_	_
28	inactive	inactive	JJ	JJ	_	27	xcomp	_	_
29	posttranslationally	posttranslationally	RB	RB	_	28	advmod	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	29	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	E47	e47	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	32	punct	_	_
36	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	isolating	isolate	VBG	VBG	_	15	advcl	_	_
3	Daudi	daudi	JJ	JJ	_	6	amod	_	_
4	x	x	NN	NN	_	6	compound	_	_
5	HeLa	hela	NN	NN	_	6	compound	_	_
6	heterokaryons	heterokaryon	NNS	NNS	_	2	dobj	_	_
7	a	a	DT	DT	_	9	det	_	_
8	few	few	JJ	JJ	_	9	amod	_	_
9	hours	hour	NNS	NNS	_	2	nmod	_	_
10	after	after	IN	IN	_	9	case	_	_
11	fusion	fusion	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	15	punct	_	_
13	we	we	PRP	PRP	_	15	nsubj	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	studied	study	VBN	VBN	_	0	root	_	_
16	the	the	DT	DT	_	18	det	_	_
17	initial	initial	JJ	JJ	_	18	amod	_	_
18	fate	fate	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	two	two	CD	CD	_	24	nummod	_	_
21	B	b	NN	NN	_	24	compound	_	_
22	cell-specific	cell-specific	JJ	JJ	_	24	amod	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	18	nmod	_	_
25	involved	involve	VBN	VBN	_	24	acl	_	_
26	in	in	IN	IN	_	29	case	_	_
27	Ig	ig	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	24	punct	_	_
31	Oct-2	oct-2	NN	NN	_	24	appos	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	3	nsubj	_	_
3	provides	provide	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	demonstration	demonstration	NN	NN	_	3	dobj	_	_
7	that	that	IN	IN	_	23	mark	_	_
8	upon	upon	IN	IN	_	9	case	_	_
9	fusion	fusion	NN	NN	_	23	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	HeLa	hela	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	23	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	contents	contents	NNS	NNS	_	23	nsubjpass	_	_
17	of	of	IN	IN	_	21	case	_	_
18	B	b	NN	NN	_	21	compound	_	_
19	cell-expressed	cell-expressed	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	16	nmod	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	depleted	deplete	VBN	VBN	_	6	ccomp	_	_
24	within	within	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	few	few	JJ	JJ	_	27	amod	_	_
27	hours	hour	NNS	NNS	_	23	nmod	_	_
28	with	with	IN	IN	_	29	case	_	_
29	kinetics	kinetics	NNS	NNS	_	23	nmod	_	_
30	that	that	WDT	WDT	_	33	nsubj	_	_
31	are	be	VBP	VBP	_	33	cop	_	_
32	as	as	IN	IN	_	33	dep	_	_
33	fast	fast	JJ	JJ	_	29	acl:relcl	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	faster	faster	JJR	JJR	_	33	conj	_	_
36	than	than	IN	IN	_	37	case	_	_
37	that	that	DT	DT	_	33	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	Ig	ig	NN	NN	_	40	compound	_	_
40	gene	gene	NN	NN	_	41	compound	_	_
41	extinction	extinction	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	extinguishing	extinguishing	NN	NN	_	5	compound	_	_
5	mechanism	mechanism	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	effective	effective	JJ	JJ	_	0	root	_	_
8	very	very	RB	RB	_	9	advmod	_	_
9	early	early	RB	RB	_	11	advmod	_	_
10	after	after	IN	IN	_	11	case	_	_
11	fusion	fusion	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	extinction	extinction	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Ig	ig	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	part	part	NN	NN	_	2	ccomp	_	_
10	of	of	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	global	global	JJ	JJ	_	13	amod	_	_
13	mechanism	mechanism	NN	NN	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	suppresses	suppress	VBZ	VBZ	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	differentiation	differentiation	NN	NN	_	18	compound	_	_
18	program	program	NN	NN	_	15	dobj	_	_
19	foreign	foreign	JJ	JJ	_	18	amod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	HeLa	hela	NN	NN	_	23	compound	_	_
23	phenotype	phenotype	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	accumulation	accumulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFAT4	nfat4	NN	NN	_	2	nmod	_	_
5	opposed	oppose	VBN	VBN	_	2	acl	_	_
6	by	by	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	JNK	jnk	NN	NN	_	11	compound	_	_
9	signal	signal	NN	NN	_	11	compound	_	_
10	transduction	transduction	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	11	det	_	_
2	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
3	factor	factor	NN	NN	_	11	compound	_	_
4	of	of	IN	IN	_	11	amod	_	_
5	activated	activate	VBN	VBN	_	11	amod	_	_
6	T	t	NN	NN	_	11	compound	_	_
7	cells	cell	NNS	NNS	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	NFAT	nfat	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	group	group	NN	NN	_	16	nsubjpass	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	retained	retain	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cytoplasm	cytoplasm	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	quiescent	quiescent	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	NFAT	nfat	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	part	part	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	induced	induce	VBN	VBN	_	10	amod	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	import	import	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	process	process	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	0	root	_	_
4	calcium-dependent	calcium-dependent	JJ	JJ	_	5	amod	_	_
5	dephosphorylation	dephosphorylation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NFAT	nfat	NN	NN	_	5	nmod	_	_
8	caused	cause	VBN	VBN	_	5	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	phosphatase	phosphatase	NN	NN	_	8	nmod	_	_
12	calcineurin	calcineurin	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	c-Jun	c-jun	NN	NN	_	4	compound	_	_
3	amino-terminal	amino-terminal	JJ	JJ	_	4	amod	_	_
4	kinase	kinase	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	JNK	jnk	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	phosphorylates	phosphorylate	VBZ	VBZ	_	0	root	_	_
9	NFAT4	nfat4	NN	NN	_	8	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	sites	site	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	removal	removal	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	JNK	jnk	NN	NN	_	7	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	2	nmod	_	_
8	caused	cause	VBD	VBD	_	0	root	_	_
9	constitutive	constitutive	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	localization	localization	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NFAT4	nfat4	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	JNK	jnk	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	9	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	calcineurin-stimulated	calcineurin-stimulated	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	caused	cause	VBD	VBD	_	0	root	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	exclusion	exclusion	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NFAT4	nfat4	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	accumulation	accumulation	NN	NN	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NFAT4	nfat4	NN	NN	_	7	nmod	_	_
10	promoted	promote	VBN	VBN	_	7	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	calcineurin	calcineurin	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	opposed	oppose	VBN	VBN	_	3	ccomp	_	_
15	by	by	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	JNK	jnk	NN	NN	_	20	compound	_	_
18	signal	signal	NN	NN	_	20	compound	_	_
19	transduction	transduction	NN	NN	_	20	compound	_	_
20	pathway	pathway	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Pathogenesis	pathogenesis	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	are	be	VBP	VBP	_	0	root	_	_
3	many	many	JJ	JJ	_	4	amod	_	_
4	hypotheses	hypothesis	NNS	NNS	_	2	nsubj	_	_
5	concerning	concern	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	pathogenesis	pathogenesis	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	endometriosis	endometriosis	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	though	though	IN	IN	_	16	mark	_	_
12	no	no	DT	DT	_	14	neg	_	_
13	single	single	JJ	JJ	_	14	amod	_	_
14	theory	theory	NN	NN	_	16	nsubj	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	explain	explain	VB	VB	_	2	advcl	_	_
17	all	all	DT	DT	_	18	det	_	_
18	cases	case	NNS	NNS	_	16	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	likely	likely	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	several	several	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	3	ccomp	_	_
9	.	.	.	.	_	3	punct	_	_

1	Early	early	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	concentrated	concentrate	VBD	VBD	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	histogenesis	histogenesis	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	endometriotic	endometriotic	JJ	JJ	_	10	amod	_	_
10	lesion	lesion	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	components	component	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	pathogenesis	pathogenesis	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	endometriosis	endometriosis	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	considers	consider	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	theories	theory	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	histogenesis	histogenesis	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	endometriosis	endometriosis	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	discusses	discuss	VBZ	VBZ	_	3	conj	_	_
16	possible	possible	JJ	JJ	_	18	amod	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	factors	factor	NNS	NNS	_	15	dobj	_	_
19	that	that	WDT	WDT	_	22	nsubjpass	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	involved	involve	VBN	VBN	_	18	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	pathophysiology	pathophysiology	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	disease	disease	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	The	the	DT	DT	_	3	det	_	_
3	value	value	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	clinical	clinical	JJ	JJ	_	7	amod	_	_
7	test	test	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	leukocytes	leukocyte	NNS	NNS	_	10	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	chronic	chronic	JJ	JJ	_	21	amod	_	_
19	pulmonary	pulmonary	JJ	JJ	_	21	amod	_	_
20	heart	heart	NN	NN	_	21	compound	_	_
21	disease	disease	NN	NN	_	16	nmod	_	_
22	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	inquire	inquire	VB	VB	_	39	advcl	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	state	state	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	adrenal	adrenal	JJ	JJ	_	11	amod	_	_
11	cortex	cortex	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	pulmonary	pulmonary	JJ	JJ	_	17	amod	_	_
16	heart	heart	NN	NN	_	17	compound	_	_
17	disease	disease	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	39	punct	_	_
19	the	the	DT	DT	_	20	det	_	_
20	number	number	NN	NN	_	39	nsubjpass	_	_
21	of	of	IN	IN	_	23	case	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	GCR	gcr	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	of	of	IN	IN	_	30	case	_	_
28	peripheral	peripheral	JJ	JJ	_	30	amod	_	_
29	blood	blood	NN	NN	_	30	compound	_	_
30	leukocytes	leukocyte	NNS	NNS	_	23	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	patients	patient	NNS	NNS	_	30	nmod	_	_
33	with	with	IN	IN	_	37	case	_	_
34	chronic	chronic	JJ	JJ	_	37	amod	_	_
35	pulmonary	pulmonary	JJ	JJ	_	37	amod	_	_
36	heart	heart	NN	NN	_	37	compound	_	_
37	disease	disease	NN	NN	_	32	nmod	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	determined	determine	VBN	VBN	_	0	root	_	_
40	with	with	IN	IN	_	42	case	_	_
41	radioligand-binding	radioligand-binding	JJ	JJ	_	42	amod	_	_
42	assay	assay	NN	NN	_	39	nmod	_	_
43	and	and	CC	CC	_	39	cc	_	_
44	the	the	DT	DT	_	48	det	_	_
45	corresponding	corresponding	JJ	JJ	_	48	amod	_	_
46	plasma	plasma	NN	NN	_	48	compound	_	_
47	cortisol	cortisol	NN	NN	_	48	compound	_	_
48	levels	level	NNS	NNS	_	50	nsubjpass	_	_
49	were	be	VBD	VBD	_	50	auxpass	_	_
50	assessed	assess	VBN	VBN	_	39	conj	_	_
51	with	with	IN	IN	_	53	case	_	_
52	radioimmune	radioimmune	JJ	JJ	_	53	amod	_	_
53	assays	assay	NNS	NNS	_	50	nmod	_	_
54	.	.	.	.	_	39	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GCR	gcr	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	reduced	reduce	VBN	VBN	_	3	ccomp	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	P	p	NN	NN	_	18	dep	_	_
17	&lt;	&lt;	JJR	JJR	_	18	advmod	_	_
18	0.01	0.01	CD	CD	_	14	parataxis	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	it	it	PRP	PRP	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	increased	increase	VBN	VBN	_	14	conj	_	_
24	when	when	WRB	WRB	_	29	advmod	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	health	health	NN	NN	_	27	compound	_	_
27	state	state	NN	NN	_	29	nsubjpass	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	improved	improve	VBN	VBN	_	23	advcl	_	_
30	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	still	still	RB	RB	_	6	advmod	_	_
6	lower	lower	JJR	JJR	_	0	root	_	_
7	than	than	IN	IN	_	8	case	_	_
8	that	that	DT	DT	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	healthy	healthy	JJ	JJ	_	11	amod	_	_
11	subjects	subject	NNS	NNS	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	P	p	NN	NN	_	15	dep	_	_
14	&lt;	&lt;	JJR	JJR	_	15	advmod	_	_
15	0.01	0.01	CD	CD	_	6	parataxis	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GCR	gcr	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	greatly	greatly	RB	RB	_	10	advmod	_	_
10	increased	increase	VBN	VBN	_	0	root	_	_
11	when	when	WRB	WRB	_	15	advmod	_	_
12	these	these	DT	DT	_	13	det	_	_
13	patients	patient	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	treated	treat	VBN	VBN	_	10	advcl	_	_
16	with	with	IN	IN	_	17	case	_	_
17	oxygen	oxygen	NN	NN	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	P	p	NN	NN	_	21	dep	_	_
20	&lt;	&lt;	JJR	JJR	_	21	advmod	_	_
21	0.01	0.01	CD	CD	_	10	parataxis	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	10	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	difference	difference	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	plasma	plasma	NN	NN	_	5	compound	_	_
5	cortisol	cortisol	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	between	between	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	patients	patient	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	subjects	subject	NNS	NNS	_	10	conj	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	P	p	NN	NN	_	18	dep	_	_
17	&gt;	&gt;	JJR	JJR	_	18	advmod	_	_
18	0.05	0.05	CD	CD	_	7	parataxis	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	function	function	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	adrenal	adrenal	JJ	JJ	_	9	amod	_	_
9	cortex	cortex	NN	NN	_	6	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	improved	improve	VBN	VBN	_	3	ccomp	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	compensation	compensation	NN	NN	_	16	compound	_	_
16	mechanism	mechanism	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	patients	patient	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	but	but	CC	CC	_	12	cc	_	_
22	the	the	DT	DT	_	25	det	_	_
23	lower	lower	JJR	JJR	_	25	amod	_	_
24	GCR	gcr	NN	NN	_	25	compound	_	_
25	number	number	NN	NN	_	28	nsubj	_	_
26	was	be	VBD	VBD	_	28	cop	_	_
27	the	the	DT	DT	_	28	det	_	_
28	result	result	NN	NN	_	12	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	lacking	lacking	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	oxygen	oxygen	NN	NN	_	30	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	patients	patient	NNS	NNS	_	30	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GCR	gcr	NN	NN	_	2	nmod	_	_
5	may	may	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	improved	improve	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	inhalation	inhalation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	oxygen	oxygen	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	oxygen	oxygen	NN	NN	_	3	compound	_	_
3	therapy	therapy	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	helpful	helpful	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	mark	_	_
7	raising	raise	VBG	VBG	_	5	advcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	controlling	control	VBG	VBG	_	7	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	development	development	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	disease	disease	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	cloning	cloning	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	characterization	characterization	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	murine	murine	JJ	JJ	_	11	amod	_	_
8	cDNA	cdna	NN	NN	_	11	compound	_	_
9	encoding	encoding	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	2	nmod	_	_
12	NFATc	nfatc	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	2	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	15	nsubj	_	_
3	of	of	IN	IN	_	14	case	_	_
4	the	the	DT	DT	_	14	det	_	_
5	NFAT	nfat	NN	NN	_	14	compound	_	_
6	(	(	-LRB-	-LRB-	_	14	punct	_	_
7	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
8	factor	factor	NN	NN	_	14	compound	_	_
9	of	of	IN	IN	_	14	amod	_	_
10	activated	activate	VBN	VBN	_	14	amod	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	cells	cell	NNS	NNS	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	family	family	NN	NN	_	2	nmod	_	_
15	play	play	VBP	VBP	_	0	root	_	_
16	important	important	JJ	JJ	_	17	amod	_	_
17	roles	role	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	immune	immune	JJ	JJ	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	inflammatory	inflammatory	JJ	JJ	_	19	conj	_	_
22	responses	response	NNS	NNS	_	19	dep	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	regulating	regulate	VBG	VBG	_	15	advcl	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	genes	gene	NNS	NNS	_	26	nmod	_	_
29	encoding	encode	VBG	VBG	_	28	acl	_	_
30	cytokines	cytokine	NNS	NNS	_	29	dobj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	immunoregulatory	immunoregulatory	JJ	JJ	_	33	amod	_	_
33	proteins	protein	NNS	NNS	_	30	conj	_	_
34	.	.	.	.	_	15	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	cloning	cloning	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	characterization	characterization	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	15	case	_	_
8	full-length	full-length	JJ	JJ	_	15	amod	_	_
9	cDNA	cdna	NN	NN	_	15	compound	_	_
10	encoding	encoding	NN	NN	_	15	compound	_	_
11	murine	murine	JJ	JJ	_	15	amod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	m	m	JJ	JJ	_	15	amod	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	NFATc	nfatc	NN	NN	_	4	nmod	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	predicts	predict	VBZ	VBZ	_	4	acl:relcl	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	protein	protein	NN	NN	_	21	nsubj	_	_
21	has	have	VBZ	VBZ	_	17	ccomp	_	_
22	all	all	PDT	PDT	_	26	dep	_	_
23	the	the	DT	DT	_	26	det	_	_
24	conserved	conserve	VBN	VBN	_	26	amod	_	_
25	structural	structural	JJ	JJ	_	26	amod	_	_
26	motifs	motif	NNS	NNS	_	21	dobj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	NFAT	nfat	NN	NN	_	30	compound	_	_
29	family	family	NN	NN	_	30	compound	_	_
30	members	member	NNS	NNS	_	26	nmod	_	_
31	,	,	,	,	_	26	punct	_	_
32	including	include	VBG	VBG	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	rel	rel	NN	NN	_	36	compound	_	_
35	homology	homology	NN	NN	_	36	compound	_	_
36	domain	domain	NN	NN	_	26	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	the	the	DT	DT	_	41	det	_	_
39	NFAT	nfat	NN	NN	_	41	compound	_	_
40	homology	homology	NN	NN	_	41	compound	_	_
41	domain	domain	NN	NN	_	36	conj	_	_
42	and	and	CC	CC	_	36	cc	_	_
43	the	the	DT	DT	_	46	det	_	_
44	nuclear	nuclear	JJ	JJ	_	46	amod	_	_
45	translocation	translocation	NN	NN	_	46	compound	_	_
46	signals	signal	NNS	NNS	_	36	conj	_	_
47	.	.	.	.	_	3	punct	_	_

1	mNFATc	mnfatc	NN	NN	_	5	nsubj	_	_
2	complexed	complex	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	4	case	_	_
4	AP-1	ap-1	NN	NN	_	2	nmod	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	specifically	specifically	RB	RB	_	5	advmod	_	_
7	to	to	TO	TO	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	murine	murine	JJ	JJ	_	13	amod	_	_
10	IL-2	il-2	NN	NN	_	13	compound	_	_
11	NFAT	nfat	NN	NN	_	13	compound	_	_
12	recognition	recognition	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	5	nmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	activated	activate	VBD	VBD	_	5	conj	_	_
16	transcription	transcription	NN	NN	_	15	dobj	_	_
17	from	from	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	co-transfected	co-transfected	JJ	JJ	_	21	amod	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	15	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	COS-7	cos-7	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cDNA	cdna	NN	NN	_	8	compound	_	_
8	probe	probe	NN	NN	_	9	nsubj	_	_
9	hybridized	hybridize	VBD	VBD	_	4	ccomp	_	_
10	with	with	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	4.5	4.5	CD	CD	_	13	compound	_	_
13	kb	kb	NN	NN	_	14	amod	_	_
14	transcript	transcript	NN	NN	_	9	nmod	_	_
15	which	which	WDT	WDT	_	18	nsubj	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	highly	highly	RB	RB	_	18	advmod	_	_
18	inducible	inducible	JJ	JJ	_	14	acl:relcl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	murine	murine	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	Northern	northern	NN	NN	_	11	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	in	in	FW	FW	_	2	conj	_	_
5	situ	situ	FW	FW	_	4	dep	_	_
6	hybridization	hybridization	NN	NN	_	2	dep	_	_
7	,	,	,	,	_	11	punct	_	_
8	mNFATc	mnfatc	NN	NN	_	9	compound	_	_
9	transcript	transcript	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	early	early	JJ	JJ	_	15	amod	_	_
15	stage	stage	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	development	development	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	mouse	mouse	NN	NN	_	4	compound	_	_
4	embryo	embryo	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	mNFATc	mnfatc	NN	NN	_	7	compound	_	_
7	transcript	transcript	NN	NN	_	10	nsubjpass	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	strongly	strongly	RB	RB	_	10	advmod	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	thymus	thymus	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	lung	lung	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	submandibular	submandibular	JJ	JJ	_	17	amod	_	_
17	gland	gland	NN	NN	_	12	conj	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	weakly	weakly	RB	RB	_	10	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	skeletal	skeletal	JJ	JJ	_	22	amod	_	_
22	muscle	muscle	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	heart	heart	NN	NN	_	22	conj	_	_
25	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
26	that	that	IN	IN	_	29	mark	_	_
27	mNFATc	mnfatc	NN	NN	_	29	nsubj	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	have	have	VB	VB	_	25	ccomp	_	_
30	a	a	DT	DT	_	31	det	_	_
31	role	role	NN	NN	_	29	dobj	_	_
32	both	both	CC	CC	_	34	cc:preconj	_	_
33	in	in	IN	IN	_	34	case	_	_
34	embryogenesis	embryogenesis	NN	NN	_	29	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	in	in	IN	IN	_	39	case	_	_
37	mature	mature	JJ	JJ	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	34	conj	_	_
40	.	.	.	.	_	10	punct	_	_

1	Differanisole	differanisole	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	antitumor	antitumor	JJ	JJ	_	5	dep	_	_
7	antibiotic	antibiotic	NN	NN	_	2	appos	_	_
8	,	,	,	,	_	2	punct	_	_
9	enhances	enhance	VBZ	VBZ	_	0	root	_	_
10	growth	growth	NN	NN	_	11	compound	_	_
11	inhibition	inhibition	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	differentiation	differentiation	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
17	leukemia	leukemia	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	induced	induce	VBN	VBN	_	11	acl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	9-cis	9-cis	JJ	JJ	_	23	amod	_	_
22	retinoic	retinoic	JJ	JJ	_	23	amod	_	_
23	acid	acid	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Differanisole	differanisole	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	7	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	3,5-dichloro-2-hydroxy-4-methoxy-6-n-propylbenzoic	3,5-dichloro-2-hydroxy-4-methoxy-6-n-propylbenzoic	JJ	JJ	_	5	amod	_	_
5	acid	acid	NN	NN	_	2	appos	_	_
6	,	,	,	,	_	2	punct	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	growth	growth	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
12	leukemia	leukemia	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	compound	compound	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	G1	g1	NN	NN	_	5	compound	_	_
5	arrest	arrest	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	granulocytic	granulocytic	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	HL-60	hl-60	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	although	although	IN	IN	_	18	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	differentiation-inducing	differentiation-inducing	JJ	JJ	_	16	amod	_	_
16	effect	effect	NN	NN	_	18	nsubj	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	modest	modest	JJ	JJ	_	3	advcl	_	_
19	.	.	.	.	_	3	punct	_	_

1	Differanisole	differanisole	NN	NN	_	11	nsubj	_	_
2	A	a	DT	DT	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	9-cis	9-cis	JJ	JJ	_	6	amod	_	_
5	retinoic	retinoic	JJ	JJ	_	6	amod	_	_
6	acid	acid	NN	NN	_	1	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	9cisRA	9cisra	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	synergistically	synergistically	RB	RB	_	11	advmod	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	growth	growth	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	induced	induce	VBD	VBD	_	16	amod	_	_
16	functional	functional	JJ	JJ	_	13	conj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	morphologic	morphologic	JJ	JJ	_	16	conj	_	_
19	differentiation	differentiation	NN	NN	_	16	dep	_	_
20	of	of	IN	IN	_	21	case	_	_
21	HL-60	hl-60	NN	NN	_	13	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	NB4	nb4	NN	NN	_	21	conj	_	_
24	cells	cell	NNS	NNS	_	21	dep	_	_
25	,	,	,	,	_	11	punct	_	_
26	whereas	whereas	IN	IN	_	42	mark	_	_
27	the	the	DT	DT	_	29	det	_	_
28	combined	combined	JJ	JJ	_	29	amod	_	_
29	treatment	treatment	NN	NN	_	42	nsubj	_	_
30	with	with	IN	IN	_	32	case	_	_
31	differanisole	differanisole	NN	NN	_	32	compound	_	_
32	A	a	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	all-trans	all-trans	JJ	JJ	_	36	amod	_	_
35	retinoic	retinoic	JJ	JJ	_	36	amod	_	_
36	acid	acid	NN	NN	_	32	conj	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	1alpha,25-dihydroxyvitamin	1alpha,25-dihydroxyvitamin	NN	NN	_	39	compound	_	_
39	D3	d3	NN	NN	_	36	conj	_	_
40	was	be	VBD	VBD	_	42	cop	_	_
41	less	less	RBR	RBR	_	42	advmod	_	_
42	effective	effective	JJ	JJ	_	11	advcl	_	_
43	.	.	.	.	_	11	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	primary	primary	JJ	JJ	_	7	amod	_	_
7	culture	culture	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	leukemia	leukemia	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	patient	patient	NN	NN	_	10	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	promyelocytic	promyelocytic	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	synergistic	synergistic	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	11	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	growth	growth	NN	NN	_	6	compound	_	_
6	inhibition	inhibition	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	induction	induction	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	differentiation	differentiation	NN	NN	_	8	nmod	_	_
11	required	require	VBD	VBD	_	0	root	_	_
12	simultaneous	simultaneous	JJ	JJ	_	13	amod	_	_
13	treatment	treatment	NN	NN	_	11	dobj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	differanisole	differanisole	NN	NN	_	16	compound	_	_
16	A	a	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	9cisRA	9cisra	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	11	punct	_	_

1	Differanisole	differanisole	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	11	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	an	a	DT	DT	_	6	det	_	_
5	RXR-specific	rxr-specific	JJ	JJ	_	6	amod	_	_
6	ligand	ligand	NN	NN	_	2	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Ro47-5944	ro47-5944	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	cooperatively	cooperatively	RB	RB	_	11	advmod	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	growth	growth	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	11	punct	_	_
16	while	while	IN	IN	_	30	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	combined	combined	JJ	JJ	_	19	amod	_	_
19	effect	effect	NN	NN	_	30	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	differanisole	differanisole	NN	NN	_	22	compound	_	_
22	A	a	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	an	a	DT	DT	_	26	det	_	_
25	RAR-specific	rar-specific	JJ	JJ	_	26	amod	_	_
26	ligand	ligand	NN	NN	_	22	conj	_	_
27	Am80	am80	NN	NN	_	26	dep	_	_
28	was	be	VBD	VBD	_	30	cop	_	_
29	just	just	RB	RB	_	30	advmod	_	_
30	additive	additive	JJ	JJ	_	11	advcl	_	_
31	.	.	.	.	_	11	punct	_	_

1	Differanisole	differanisole	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	8	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	combination	combination	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	9cisRA	9cisra	NN	NN	_	4	nmod	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	have	have	VB	VB	_	0	root	_	_
9	implications	implication	NNS	NNS	_	8	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	therapy	therapy	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	acute	acute	JJ	JJ	_	16	amod	_	_
14	promyelocytic	promyelocytic	JJ	JJ	_	16	amod	_	_
15	leukemia	leukemia	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	anoxia/reoxygenation-induced	anoxia/reoxygenation-induced	JJ	JJ	_	6	amod	_	_
5	neutrophil	neutrophil	NN	NN	_	6	compound	_	_
6	adherence	adherence	NN	NN	_	2	nmod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	cultured	culture	VBN	VBN	_	10	amod	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	objectives	objective	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	11	mark	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	1	1	LS	LS	_	11	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	determine	determine	VB	VB	_	6	xcomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	time	time	NN	NN	_	14	compound	_	_
14	course	course	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	neutrophil	neutrophil	NN	NN	_	17	compound	_	_
17	adhesion	adhesion	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	monolayers	monolayer	NNS	NNS	_	17	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	umbilical	umbilical	JJ	JJ	_	25	amod	_	_
23	vein	vein	NN	NN	_	25	compound	_	_
24	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	19	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	HUVECs	huvec	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	that	that	WDT	WDT	_	31	nsubjpass	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	exposed	expose	VBN	VBN	_	19	acl:relcl	_	_
32	to	to	TO	TO	_	34	case	_	_
33	60	60	CD	CD	_	34	nummod	_	_
34	minutes	minute	NNS	NNS	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	anoxia	anoxia	NN	NN	_	34	nmod	_	_
37	followed	follow	VBN	VBN	_	34	acl	_	_
38	by	by	IN	IN	_	42	case	_	_
39	30	30	CD	CD	_	41	compound	_	_
40	to	to	TO	TO	_	41	dep	_	_
41	600	600	CD	CD	_	42	nummod	_	_
42	minutes	minute	NNS	NNS	_	37	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	reoxygenation	reoxygenation	NN	NN	_	42	nmod	_	_
45	and	and	CC	CC	_	11	cc	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	2	2	LS	LS	_	49	dep	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	define	define	VB	VB	_	11	conj	_	_
50	the	the	DT	DT	_	51	det	_	_
51	mechanisms	mechanism	NNS	NNS	_	49	dobj	_	_
52	responsible	responsible	JJ	JJ	_	51	amod	_	_
53	for	for	IN	IN	_	56	case	_	_
54	both	both	CC	CC	_	56	cc:preconj	_	_
55	the	the	DT	DT	_	56	dep	_	_
56	early	early	JJ	JJ	_	52	nmod	_	_
57	(	(	-LRB-	-LRB-	_	58	punct	_	_
58	minutes	minute	NNS	NNS	_	56	dep	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	and	and	CC	CC	_	56	cc	_	_
61	late	late	JJ	JJ	_	56	conj	_	_
62	(	(	-LRB-	-LRB-	_	63	punct	_	_
63	hours	hour	NNS	NNS	_	61	dep	_	_
64	)	)	-RRB-	-RRB-	_	63	punct	_	_
65	hyperadhesivity	hyperadhesivity	NN	NN	_	56	dep	_	_
66	of	of	IN	IN	_	68	case	_	_
67	postanoxic	postanoxic	JJ	JJ	_	68	amod	_	_
68	HUVECs	huvec	NNS	NNS	_	65	nmod	_	_
69	to	to	TO	TO	_	71	case	_	_
70	human	human	JJ	JJ	_	71	amod	_	_
71	neutrophils	neutrophil	NNS	NNS	_	65	nmod	_	_
72	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	clearly	clearly	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	anoxia/reoxygenation	anoxia/reoxygenation	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	A/R	a/r	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	leads	lead	VBZ	VBZ	_	4	ccomp	_	_
11	to	to	TO	TO	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	biphasic	biphasic	JJ	JJ	_	14	amod	_	_
14	increase	increase	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	neutrophil	neutrophil	NN	NN	_	17	compound	_	_
17	adhesion	adhesion	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	HUVECs	huvec	NNS	NNS	_	17	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	with	with	IN	IN	_	24	mark	_	_
22	peak	peak	NN	NN	_	23	compound	_	_
23	responses	response	NNS	NNS	_	24	nsubj	_	_
24	occurring	occur	VBG	VBG	_	10	advcl	_	_
25	at	at	IN	IN	_	27	case	_	_
26	30	30	CD	CD	_	27	nummod	_	_
27	minutes	minute	NNS	NNS	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	phase	phase	NN	NN	_	27	appos	_	_
30	1	1	CD	CD	_	29	nummod	_	_
31	)	)	-RRB-	-RRB-	_	29	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	240	240	CD	CD	_	34	nummod	_	_
34	minutes	minute	NNS	NNS	_	27	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	phase	phase	NN	NN	_	34	appos	_	_
37	2	2	CD	CD	_	36	nummod	_	_
38	)	)	-RRB-	-RRB-	_	36	punct	_	_
39	after	after	IN	IN	_	40	case	_	_
40	reoxygenation	reoxygenation	NN	NN	_	27	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	Oxypurinol	oxypurinol	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	catalase	catalase	NN	NN	_	1	conj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	phase-1	phase-1	JJ	JJ	_	6	amod	_	_
6	adhesion	adhesion	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	4	punct	_	_
8	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
9	a	a	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	xanthine	xanthine	NN	NN	_	13	compound	_	_
13	oxidase	oxidase	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	H2O2	h2o2	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	platelet	platelet	NN	NN	_	6	compound	_	_
5	activating	activating	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PAF	paf	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	contributed	contribute	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	both	both	CC	CC	_	13	dep	_	_
13	phases	phase	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	neutrophil	neutrophil	NN	NN	_	16	compound	_	_
16	adhesion	adhesion	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Anti-intercellular	anti-intercellular	JJ	JJ	_	3	amod	_	_
2	adhesion	adhesion	NN	NN	_	3	compound	_	_
3	molecule-1	molecule-1	NN	NN	_	17	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	ICAM-1	icam-1	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	anti-P-selectin	anti-p-selectin	JJ	JJ	_	9	amod	_	_
9	antibodies	antibody	NNS	NNS	_	3	conj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	monoclonal	monoclonal	JJ	JJ	_	12	amod	_	_
12	antibodies	antibody	NNS	NNS	_	9	dep	_	_
13	-LSB-	-lsb-	-LRB-	-LRB-	_	14	punct	_	_
14	mAbs	mab	NNS	NNS	_	12	appos	_	_
15	-RSB-	-rsb-	-RRB-	-RRB-	_	14	punct	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	attenuated	attenuate	VBD	VBD	_	0	root	_	_
18	phase-1	phase-1	JJ	JJ	_	20	amod	_	_
19	neutrophil	neutrophil	NN	NN	_	20	compound	_	_
20	adhesion	adhesion	NN	NN	_	17	dobj	_	_
21	,	,	,	,	_	17	punct	_	_
22	consistent	consistent	JJ	JJ	_	17	advmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	roles	role	NNS	NNS	_	22	nmod	_	_
25	for	for	IN	IN	_	28	case	_	_
26	constitutively	constitutively	RB	RB	_	27	advmod	_	_
27	expressed	express	VBN	VBN	_	28	amod	_	_
28	ICAM-1	icam-1	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	enhanced	enhance	VBN	VBN	_	32	amod	_	_
31	surface	surface	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	28	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	preformed	preformed	JJ	JJ	_	35	amod	_	_
35	P-selectin	p-selectin	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	17	punct	_	_

1	Phase-2	phase-2	NN	NN	_	3	compound	_	_
2	neutrophil	neutrophil	NN	NN	_	3	compound	_	_
3	adhesion	adhesion	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	attenuated	attenuate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	anti-E-selectin	anti-e-selectin	JJ	JJ	_	9	amod	_	_
9	mAb	mab	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	indicating	indicate	VBG	VBG	_	5	advcl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	dominant	dominant	JJ	JJ	_	14	amod	_	_
14	role	role	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	this	this	DT	DT	_	18	det	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecule	molecule	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	late	late	JJ	JJ	_	23	amod	_	_
22	phase	phase	NN	NN	_	23	compound	_	_
23	response	response	NN	NN	_	14	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	23	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	actinomycin	actinomycin	NN	NN	_	4	compound	_	_
4	D	d	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cycloheximide	cycloheximide	NN	NN	_	4	conj	_	_
7	or	or	CC	CC	_	4	cc	_	_
8	with	with	IN	IN	_	10	case	_	_
9	competing	compete	VBG	VBG	_	10	amod	_	_
10	ds-oligonucleotides	ds-oligonucleotide	NNS	NNS	_	4	conj	_	_
11	containing	contain	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	15	det	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	factor-kappa	factor-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	11	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	activator	activator	NN	NN	_	18	compound	_	_
18	protein-1	protein-1	NN	NN	_	15	conj	_	_
19	cognate	cognate	NN	NN	_	21	compound	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	sequences	sequence	NNS	NNS	_	18	dep	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	attenuated	attenuate	VBD	VBD	_	0	root	_	_
24	phase-2	phase-2	NN	NN	_	25	compound	_	_
25	response	response	NN	NN	_	23	dobj	_	_
26	,	,	,	,	_	23	punct	_	_
27	suggesting	suggest	VBG	VBG	_	23	advcl	_	_
28	a	a	DT	DT	_	29	det	_	_
29	role	role	NN	NN	_	27	dobj	_	_
30	for	for	IN	IN	_	34	case	_	_
31	de	de	FW	FW	_	34	amod	_	_
32	novo	novo	FW	FW	_	31	dep	_	_
33	macromolecule	macromolecule	NN	NN	_	34	compound	_	_
34	synthesis	synthesis	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	23	punct	_	_

1	Surface	surface	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ICAM-1	icam-1	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	P-selectin	p-selectin	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	E-selectin	e-selectin	NN	NN	_	4	conj	_	_
10	on	on	IN	IN	_	11	case	_	_
11	HUVECs	huvec	NNS	NNS	_	2	nmod	_	_
12	correlated	correlate	VBD	VBD	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	phase-1	phase-1	JJ	JJ	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	-2	-2	CD	CD	_	15	conj	_	_
18	neutrophil	neutrophil	NN	NN	_	20	compound	_	_
19	adhesion	adhesion	NN	NN	_	20	compound	_	_
20	responses	response	NNS	NNS	_	15	dep	_	_
21	.	.	.	.	_	12	punct	_	_

1	Collectively	collectively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	A/R	a/r	NN	NN	_	8	nsubj	_	_
8	elicits	elicit	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	14	det	_	_
10	two-phase	two-phase	JJ	JJ	_	14	amod	_	_
11	neutrophil-endothelial	neutrophil-endothelial	JJ	JJ	_	14	amod	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	adhesion	adhesion	NN	NN	_	14	compound	_	_
14	response	response	NN	NN	_	8	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	involves	involve	VBZ	VBZ	_	14	acl:relcl	_	_
17	transcription-independent	transcription-independent	JJ	JJ	_	16	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	transcription-dependent	transcription-dependent	JJ	JJ	_	17	conj	_	_
20	surface	surface	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	dep	_	_
22	of	of	IN	IN	_	27	case	_	_
23	different	different	JJ	JJ	_	27	amod	_	_
24	endothelial	endothelial	JJ	JJ	_	27	amod	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	molecules	molecule	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	9	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	chronic	chronic	JJ	JJ	_	8	amod	_	_
7	lymphocytic	lymphocytic	JJ	JJ	_	8	amod	_	_
8	leukemia	leukemia	NN	NN	_	4	nmod	_	_
9	contain	contain	VBP	VBP	_	0	root	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transducer	transducer	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	activator	activator	NN	NN	_	17	compound	_	_
14	of	of	IN	IN	_	17	amod	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	STAT	stat	NN	NN	_	11	conj	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	1	1	CD	CD	_	17	nummod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	STAT3	stat3	NN	NN	_	11	conj	_	_
22	constitutively	constitutively	RB	RB	_	23	advmod	_	_
23	phosphorylated	phosphorylate	VBN	VBN	_	11	acl	_	_
24	on	on	IN	IN	_	26	case	_	_
25	serine	serine	NN	NN	_	26	compound	_	_
26	residues	residue	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	explore	explore	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	pathogenesis	pathogenesis	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	chronic	chronic	JJ	JJ	_	8	amod	_	_
7	lymphocytic	lymphocytic	JJ	JJ	_	8	amod	_	_
8	leukemia	leukemia	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CLL	cll	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	2	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	examined	examine	VBD	VBD	_	2	parataxis	_	_
15	whether	whether	IN	IN	_	32	mark	_	_
16	phosphorylation	phosphorylation	NN	NN	_	32	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	one	one	CD	CD	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	more	more	JJR	JJR	_	18	conj	_	_
21	signal	signal	NN	NN	_	22	compound	_	_
22	transducer	transducer	NN	NN	_	18	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	activator	activator	NN	NN	_	30	compound	_	_
25	of	of	IN	IN	_	30	amod	_	_
26	transcription	transcription	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	STAT	stat	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	factors	factor	NNS	NNS	_	22	conj	_	_
31	was	be	VBD	VBD	_	32	cop	_	_
32	abnormal	abnormal	JJ	JJ	_	14	ccomp	_	_
33	in	in	IN	IN	_	34	case	_	_
34	cells	cell	NNS	NNS	_	32	nmod	_	_
35	from	from	IN	IN	_	37	case	_	_
36	CLL	cll	NN	NN	_	37	compound	_	_
37	patients	patient	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	No	no	DT	DT	_	4	neg	_	_
2	constitutive	constitutive	JJ	JJ	_	4	amod	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	on	on	IN	IN	_	9	case	_	_
8	any	any	DT	DT	_	9	det	_	_
9	STAT	stat	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	CLL	cll	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	assess	assess	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	serine	serine	NN	NN	_	7	compound	_	_
7	residues	residue	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	STAT1	stat1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	STAT3	stat3	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	CLL	cll	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	raised	raise	VBD	VBD	_	2	parataxis	_	_
18	antibodies	antibody	NNS	NNS	_	17	dobj	_	_
19	that	that	WDT	WDT	_	21	nsubj	_	_
20	specifically	specifically	RB	RB	_	21	advmod	_	_
21	recognize	recognize	VBP	VBP	_	18	acl:relcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	form	form	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	STAT1	stat1	NN	NN	_	23	nmod	_	_
26	phosphorylated	phosphorylate	VBN	VBN	_	25	acl	_	_
27	on	on	IN	IN	_	28	case	_	_
28	ser-727	ser-727	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	23	cc	_	_
30	the	the	DT	DT	_	31	det	_	_
31	form	form	NN	NN	_	23	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	STAT3	stat3	NN	NN	_	31	nmod	_	_
34	phosphorylated	phosphorylate	VBN	VBN	_	33	acl	_	_
35	on	on	IN	IN	_	36	case	_	_
36	ser-727	ser-727	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	22	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	100	100	CD	CD	_	6	nummod	_	_
6	%	%	NN	NN	_	22	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	CLL	cll	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	n	n	NN	NN	_	8	dep	_	_
13	=	=	JJ	JJ	_	12	amod	_	_
14	32	32	CD	CD	_	13	dep	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	,	,	,	,	_	22	punct	_	_
17	STAT1	stat1	NN	NN	_	22	nsubjpass	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	STAT3	stat3	NN	NN	_	17	conj	_	_
20	were	be	VBD	VBD	_	22	auxpass	_	_
21	constitutively	constitutively	RB	RB	_	22	advmod	_	_
22	phosphorylated	phosphorylate	VBN	VBN	_	2	ccomp	_	_
23	on	on	IN	IN	_	24	case	_	_
24	serine	serine	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	4	nsubj	_	_
2	was	be	VBD	VBD	_	4	cop	_	_
3	in	in	IN	IN	_	4	case	_	_
4	contrast	contrast	NN	NN	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
8	blood	blood	NN	NN	_	4	nmod	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	8	dep	_	_
11	or	or	CC	CC	_	8	cc	_	_
12	CD5+)	cd5+)	JJ	JJ	_	14	amod	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	conj	_	_
15	isolated	isolate	VBN	VBN	_	8	acl	_	_
16	from	from	IN	IN	_	17	case	_	_
17	tonsils	tonsil	NNS	NNS	_	15	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	24	nmod	_	_
21	this	this	DT	DT	_	22	det	_	_
22	phosphorylation	phosphorylation	NN	NN	_	24	nsubj	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	absent	absent	JJ	JJ	_	8	acl:relcl	_	_
25	.	.	.	.	_	4	punct	_	_

1	Serine	serine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT1	stat1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	STAT3	stat3	NN	NN	_	4	conj	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	seen	see	VBN	VBN	_	0	root	_	_
9	occasionally	occasionally	RB	RB	_	8	advmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	other	other	JJ	JJ	_	12	amod	_	_
12	leukemias	leukemia	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	but	but	CC	CC	_	8	cc	_	_
15	it	it	PRP	PRP	_	19	nsubj	_	_
16	was	be	VBD	VBD	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	universal	universal	JJ	JJ	_	19	amod	_	_
19	finding	finding	NN	NN	_	8	conj	_	_
20	only	only	RB	RB	_	22	advmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	CLL	cll	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	serine	serine	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	STATs	stats	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	continuous	continuous	JJ	JJ	_	10	amod	_	_
10	process	process	NN	NN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	as	as	IN	IN	_	22	mark	_	_
13	incubation	incubation	NN	NN	_	22	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	CLL	cll	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	kinase	kinase	NN	NN	_	21	compound	_	_
20	inhibitor	inhibitor	NN	NN	_	21	compound	_	_
21	H7	h7	NN	NN	_	13	nmod	_	_
22	led	lead	VBD	VBD	_	10	advcl	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	dephosphorylation	dephosphorylation	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	these	these	DT	DT	_	29	det	_	_
28	serine	serine	NN	NN	_	29	compound	_	_
29	residues	residue	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	STAT	stat	NN	NN	_	4	compound	_	_
3	serine	serine	NN	NN	_	4	compound	_	_
4	kinase	kinase	NN	NN	_	11	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	CLL	cll	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	has	have	VBZ	VBZ	_	11	aux	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	appears	appear	VBZ	VBZ	_	11	conj	_	_
15	to	to	TO	TO	_	20	mark	_	_
16	be	be	VB	VB	_	20	cop	_	_
17	neither	neither	DT	DT	_	20	cc:preconj	_	_
18	mitogen-activated	mitogen-activated	JJ	JJ	_	20	amod	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	kinase	kinase	NN	NN	_	14	xcomp	_	_
21	nor	nor	CC	CC	_	20	cc	_	_
22	pp70(s6k)	pp70(s6k)	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
6	serine	serine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	STAT1	stat1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	STAT3	stat3	NN	NN	_	9	conj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	present	present	JJ	JJ	_	0	root	_	_
14	in	in	IN	IN	_	17	case	_	_
15	all	all	DT	DT	_	17	det	_	_
16	CLL	cll	NN	NN	_	17	compound	_	_
17	samples	sample	NNS	NNS	_	13	nmod	_	_
18	tested	test	VBN	VBN	_	17	acl	_	_
19	to	to	TO	TO	_	20	case	_	_
20	date	date	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	although	although	IN	IN	_	29	mark	_	_
23	the	the	DT	DT	_	25	det	_	_
24	physiologic	physiologic	JJ	JJ	_	25	amod	_	_
25	significance	significance	NN	NN	_	29	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	modification	modification	NN	NN	_	25	nmod	_	_
29	remains	remain	VBZ	VBZ	_	13	advcl	_	_
30	to	to	TO	TO	_	32	mark	_	_
31	be	be	VB	VB	_	32	auxpass	_	_
32	determined	determine	VBN	VBN	_	29	xcomp	_	_
33	.	.	.	.	_	13	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	8	det	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	corticotropin-releasing	corticotropin-releasing	JJ	JJ	_	8	amod	_	_
6	hormone	hormone	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	2	dobj	_	_
9	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	studies	study	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	identify	identify	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	18	mark	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	18	nsubj	_	_
12	,	,	,	,	_	11	punct	_	_
13	associated	associate	VBN	VBN	_	11	acl	_	_
14	with	with	IN	IN	_	16	case	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	signalling	signalling	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	affected	affect	VBD	VBD	_	8	ccomp	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	29	case	_	_
22	the	the	DT	DT	_	29	det	_	_
23	corticotropin	corticotropin	NN	NN	_	29	compound	_	_
24	releasing	releasing	NN	NN	_	29	compound	_	_
25	hormone	hormone	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	CRH	crh	NN	NN	_	29	compound	_	_
28	)	)	-RRB-	-RRB-	_	29	punct	_	_
29	gene	gene	NN	NN	_	20	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	Fragments	fragment	NNS	NNS	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	3.6	3.6	CD	CD	_	5	compound	_	_
5	kb	kb	NN	NN	_	6	amod	_	_
6	sequence	sequence	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	CRH	crh	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	6	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	amplified	amplify	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PCR	pcr	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	ligated	ligate	VBN	VBN	_	14	conj	_	_
19	upstream	upstream	RB	RB	_	18	advmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	CAT	cat	NN	NN	_	23	compound	_	_
23	reporter	reporter	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	constructs	construct	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	transfected	transfect	VBN	VBN	_	0	root	_	_
5	into	into	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	variety	variety	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	either	either	CC	CC	_	14	cc:preconj	_	_
13	alone	alone	RB	RB	_	14	advmod	_	_
14	or	or	CC	CC	_	4	advmod	_	_
15	together	together	RB	RB	_	14	advmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	with	with	IN	IN	_	21	case	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	21	compound	_	_
20	expression	expression	NN	NN	_	21	compound	_	_
21	vectors	vector	NNS	NNS	_	4	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Basal	basal	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	9	case	_	_
4	a	a	DT	DT	_	9	det	_	_
5	3070	3070	CD	CD	_	9	nummod	_	_
6	bp	bp	NN	NN	_	9	compound	_	_
7	CRH	crh	NN	NN	_	9	compound	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	fragment	fragment	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	only	only	RB	RB	_	12	advmod	_	_
12	seen	see	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	neuronal	neuronal	JJ	JJ	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	lymphoblastoid	lymphoblastoid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	Promoter	promoter	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	increased	increase	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	nmod	_	_
9	C/EBPbeta	c/ebpbeta	NN	NN	_	8	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	NF-IL6	nf-il6	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	strongly	strongly	RB	RB	_	8	conj	_	_
16	,	,	,	,	_	8	punct	_	_
17	by	by	IN	IN	_	18	case	_	_
18	C/EBPdelta	c/ebpdelta	NN	NN	_	8	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	NF-IL6beta	nf-il6beta	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	4	punct	_	_

1	Increased	increase	VBN	VBN	_	4	amod	_	_
2	CRH	crh	NN	NN	_	4	compound	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	10	nsubjpass	_	_
5	following	follow	VBG	VBG	_	8	case	_	_
6	phorbol	phorbol	NN	NN	_	8	compound	_	_
7	ester	ester	NN	NN	_	8	compound	_	_
8	treatment	treatment	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	dominant	dominant	JJ	JJ	_	16	amod	_	_
14	negative	negative	JJ	JJ	_	16	amod	_	_
15	NF-IL6	nf-il6	NN	NN	_	16	compound	_	_
16	mutant	mutant	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	showing	show	VBG	VBG	_	10	advcl	_	_
19	that	that	IN	IN	_	27	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	effects	effect	NNS	NNS	_	27	nsubjpass	_	_
22	of	of	IN	IN	_	24	case	_	_
23	phorbol	phorbol	NN	NN	_	24	compound	_	_
24	ester	ester	NN	NN	_	21	nmod	_	_
25	were	be	VBD	VBD	_	27	auxpass	_	_
26	principally	principally	RB	RB	_	27	advmod	_	_
27	mediated	mediate	VBN	VBN	_	18	ccomp	_	_
28	by	by	IN	IN	_	29	case	_	_
29	C/EBP	c/ebp	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	inverse	inverse	JJ	JJ	_	5	amod	_	_
5	changes	change	NNS	NNS	_	20	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CRH	crh	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	dep	_	_
13	hypothalamus	hypothalamus	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	spleens	spleen	NNS	NNS	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	arthritic	arthritic	JJ	JJ	_	18	amod	_	_
18	rats	rat	NNS	NNS	_	13	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	paralleled	parallel	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	24	case	_	_
22	similar	similar	JJ	JJ	_	24	amod	_	_
23	inverse	inverse	NN	NN	_	24	compound	_	_
24	changes	change	NNS	NNS	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	NF-IL6beta	nf-il6beta	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	organs	organ	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	some	some	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	14	nsubj	_	_
8	associated	associate	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	11	case	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	signalling	signalling	NN	NN	_	8	nmod	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	activate	activate	VB	VB	_	3	ccomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CRH	crh	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	novel	novel	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	myeloid-specific	myeloid-specific	JJ	JJ	_	9	amod	_	_
7	zinc	zinc	NN	NN	_	9	compound	_	_
8	finger	finger	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	MZF-2	mzf-2	NN	NN	_	3	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	3	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Myeloid	myeloid	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	development	development	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	controlled	control	VBN	VBN	_	1	dep	_	_
8	by	by	IN	IN	_	11	case	_	_
9	tissue-specific	tissue-specific	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	myeloid	myeloid	JJ	JJ	_	5	amod	_	_
3	zinc	zinc	NN	NN	_	5	compound	_	_
4	finger	finger	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	13	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MZF-1	mzf-1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	putative	putative	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	0	root	_	_
14	containing	contain	VBG	VBG	_	13	acl	_	_
15	13	13	CD	CD	_	17	nummod	_	_
16	zinc	zinc	NN	NN	_	17	compound	_	_
17	fingers	finger	NNS	NNS	_	14	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	suggested	suggest	VBN	VBN	_	13	conj	_	_
23	that	that	IN	IN	_	25	mark	_	_
24	it	it	PRP	PRP	_	25	nsubj	_	_
25	regulates	regulate	VBZ	VBZ	_	22	ccomp	_	_
26	the	the	DT	DT	_	27	det	_	_
27	development	development	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	neutrophilic	neutrophilic	JJ	JJ	_	30	amod	_	_
30	granulocytes	granulocyte	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Here	here	RB	RB	_	7	advmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	isolated	isolate	VBN	VBN	_	1	dep	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	murine	murine	JJ	JJ	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	human	human	JJ	JJ	_	9	conj	_	_
12	cDNAs	cdna	NNS	NNS	_	9	dep	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	encode	encode	VBP	VBP	_	9	acl:relcl	_	_
15	a	a	DT	DT	_	17	det	_	_
16	novel	novel	JJ	JJ	_	17	amod	_	_
17	form	form	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	MZF	mzf	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	MZF-2	mzf-2	NN	NN	_	17	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	1	punct	_	_

1	Murine	murine	JJ	JJ	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	human	human	JJ	JJ	_	1	conj	_	_
4	MZF-2	mzf-2	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	1	dep	_	_
6	consisted	consist	VBD	VBD	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	814	814	CD	CD	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	775	775	CD	CD	_	8	conj	_	_
11	amino	amino	NN	NN	_	12	compound	_	_
12	acids	acid	NNS	NNS	_	8	dep	_	_
13	,	,	,	,	_	6	punct	_	_
14	respectively	respectively	RB	RB	_	6	advmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	have	have	VBP	VBP	_	6	conj	_	_
18	identity	identity	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	75.3	75.3	CD	CD	_	21	nummod	_	_
21	%	%	NN	NN	_	18	nmod	_	_
22	between	between	IN	IN	_	23	case	_	_
23	them	they	PRP	PRP	_	17	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	C-terminal	c-terminal	JJ	JJ	_	3	amod	_	_
3	half	half	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	MZF-2	mzf-2	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	carrying	carry	VBG	VBG	_	3	acl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	zinc	zinc	NN	NN	_	12	compound	_	_
11	finger	finger	NN	NN	_	12	compound	_	_
12	domains	domain	NNS	NNS	_	8	dobj	_	_
13	,	,	,	,	_	3	punct	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	completely	completely	RB	RB	_	16	advmod	_	_
16	identical	identical	JJ	JJ	_	0	root	_	_
17	with	with	IN	IN	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	MZF-1	mzf-1	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	whereas	whereas	IN	IN	_	30	mark	_	_
24	the	the	DT	DT	_	26	det	_	_
25	N-terminal	n-terminal	JJ	JJ	_	26	amod	_	_
26	half	half	NN	NN	_	30	nsubj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	MZF-2	mzf-2	NN	NN	_	26	nmod	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	different	different	JJ	JJ	_	16	advcl	_	_
31	from	from	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	corresponding	corresponding	JJ	JJ	_	34	amod	_	_
34	region	region	NN	NN	_	30	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	MZF-1	mzf-1	NN	NN	_	34	nmod	_	_
38	,	,	,	,	_	30	punct	_	_
39	and	and	CC	CC	_	30	cc	_	_
40	was	be	VBD	VBD	_	41	auxpass	_	_
41	coded	code	VBN	VBN	_	30	conj	_	_
42	by	by	IN	IN	_	44	case	_	_
43	distinct	distinct	JJ	JJ	_	44	amod	_	_
44	exons	exon	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	16	punct	_	_

1	MZF-2	mzf-2	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	myeloid	myeloid	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	advcl	_	_
8	,	,	,	,	_	7	punct	_	_
9	particularly	particularly	RB	RB	_	12	advmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	committed	commit	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	neutrophilic	neutrophilic	JJ	JJ	_	17	amod	_	_
17	lineage	lineage	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	down-regulated	down-regulate	VBN	VBN	_	4	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	G-CSF	g-csf	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	MZF-1	mzf-1	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	MZF-2	mzf-2	NN	NN	_	3	conj	_	_
6	mRNAs	mrna	NNS	NNS	_	3	dep	_	_
7	seem	seem	VBP	VBP	_	1	dep	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	produced	produce	VBN	VBN	_	7	xcomp	_	_
11	by	by	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	alternative	alternative	JJ	JJ	_	14	amod	_	_
14	use	use	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	two	two	CD	CD	_	20	nummod	_	_
17	different	different	JJ	JJ	_	20	amod	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	initiation	initiation	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	distinct	distinct	JJ	JJ	_	4	amod	_	_
3	N-terminal	n-terminal	JJ	JJ	_	4	amod	_	_
4	half	half	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	MZF-2	mzf-2	NN	NN	_	4	nmod	_	_
7	carries	carry	VBZ	VBZ	_	0	root	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	characteristic	characteristic	JJ	JJ	_	10	amod	_	_
10	domains	domain	NNS	NNS	_	7	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	14	det	_	_
13	leucine-rich	leucine-rich	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	10	appos	_	_
15	called	call	VBN	VBN	_	14	acl	_	_
16	LeR	ler	NN	NN	_	15	xcomp	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	an	a	DT	DT	_	20	det	_	_
19	acidic	acidic	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	7	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	suggests	suggest	VBZ	VBZ	_	7	dep	_	_
24	a	a	DT	DT	_	26	det	_	_
25	unique	unique	JJ	JJ	_	26	amod	_	_
26	function	function	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	MZF-2	mzf-2	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	neutrophil	neutrophil	NN	NN	_	31	compound	_	_
31	development	development	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	c-Rel	c-rel	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	p65	p65	NN	NN	_	1	conj	_	_
4	subunits	subunit	NNS	NNS	_	1	dep	_	_
5	bind	bind	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	upstream	upstream	JJ	JJ	_	10	amod	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	17	case	_	_
12	human	human	JJ	JJ	_	17	amod	_	_
13	granulocyte	granulocyte	NN	NN	_	17	compound	_	_
14	macrophage-colony	macrophage-colony	NN	NN	_	17	compound	_	_
15	stimulating	stimulating	NN	NN	_	17	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	10	nmod	_	_
18	involved	involve	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	phorbol	phorbol	NN	NN	_	22	compound	_	_
21	ester	ester	NN	NN	_	22	compound	_	_
22	response	response	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	5637	5637	CD	CD	_	25	nummod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	clarify	clarify	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	complex	complex	JJ	JJ	_	7	amod	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	GM-CSF	gm-csf	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	which	which	WDT	WDT	_	17	nsubjpass	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	extensively	extensively	RB	RB	_	17	advmod	_	_
17	investigated	investigate	VBN	VBN	_	7	acl:relcl	_	_
18	in	in	IN	IN	_	21	case	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	3	punct	_	_
23	we	we	PRP	PRP	_	25	nsubj	_	_
24	have	have	VBP	VBP	_	25	aux	_	_
25	studied	study	VBN	VBN	_	3	parataxis	_	_
26	the	the	DT	DT	_	27	det	_	_
27	role	role	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	33	case	_	_
29	an	a	DT	DT	_	33	det	_	_
30	upstream	upstream	JJ	JJ	_	33	amod	_	_
31	NF-kappaB	nf-kappab	NN	NN	_	33	compound	_	_
32	like	like	JJ	JJ	_	33	amod	_	_
33	site	site	NN	NN	_	27	nmod	_	_
34	in	in	IN	IN	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	5637	5637	CD	CD	_	39	nummod	_	_
37	non-lymphoid	non-lymphoid	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	33	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	which	which	WDT	WDT	_	42	nsubj	_	_
42	derives	derive	VBZ	VBZ	_	39	acl:relcl	_	_
43	from	from	IN	IN	_	46	case	_	_
44	a	a	DT	DT	_	46	det	_	_
45	bladder	bladder	NN	NN	_	46	compound	_	_
46	carcinoma	carcinoma	NN	NN	_	42	nmod	_	_
47	and	and	CC	CC	_	42	cc	_	_
48	constitutively	constitutively	RB	RB	_	49	advmod	_	_
49	produces	produce	VBZ	VBZ	_	42	conj	_	_
50	GM-CSF	gm-csf	NN	NN	_	49	dobj	_	_
51	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	named	name	VBN	VBN	_	2	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	A	a	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	4	xcomp	_	_
8	,	,	,	,	_	2	punct	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	an	a	DT	DT	_	12	det	_	_
11	active	active	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	GM-CSF	gm-csf	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	responsive	responsive	JJ	JJ	_	9	conj	_	_
19	to	to	TO	TO	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	tumor	tumor	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	PMA	pma	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	transient	transient	JJ	JJ	_	27	amod	_	_
26	transfection	transfection	NN	NN	_	27	compound	_	_
27	experiments	experiment	NNS	NNS	_	18	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	a	a	DT	DT	_	7	det	_	_
5	heterodimeric	heterodimeric	JJ	JJ	_	7	amod	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	2	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	subunits	subunit	NNS	NNS	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	c-Rel	c-rel	NN	NN	_	10	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	p65	p65	NN	NN	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	identical	identical	JJ	JJ	_	2	dep	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	one	one	CD	CD	_	18	nmod	_	_
22	obtained	obtain	VBN	VBN	_	21	acl	_	_
23	using	use	VBG	VBG	_	22	xcomp	_	_
24	the	the	DT	DT	_	26	det	_	_
25	HIV-LTR-kappaB	hiv-ltr-kappab	NN	NN	_	26	compound	_	_
26	site	site	NN	NN	_	23	dobj	_	_
27	as	as	IN	IN	_	29	case	_	_
28	recognition	recognition	NN	NN	_	29	compound	_	_
29	sequence	sequence	NN	NN	_	23	nmod	_	_
30	and	and	CC	CC	_	18	cc	_	_
31	different	different	JJ	JJ	_	18	conj	_	_
32	from	from	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	one	one	CD	CD	_	31	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	c-Rel	c-rel	NN	NN	_	34	dep	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	p50	p50	NN	NN	_	36	conj	_	_
39	)	)	-RRB-	-RRB-	_	36	punct	_	_
40	observed	observe	VBN	VBN	_	34	acl	_	_
41	with	with	IN	IN	_	43	case	_	_
42	nuclear	nuclear	JJ	JJ	_	43	amod	_	_
43	extracts	extract	NNS	NNS	_	40	nmod	_	_
44	from	from	IN	IN	_	49	case	_	_
45	Mo	mo	NN	NN	_	49	compound	_	_
46	T-lymphoid	t-lymphoid	NN	NN	_	49	compound	_	_
47	HTLV-II	htlv-ii	NN	NN	_	49	compound	_	_
48	infected	infected	JJ	JJ	_	49	amod	_	_
49	cells	cell	NNS	NNS	_	43	nmod	_	_
50	.	.	.	.	_	2	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	monocyte	monocyte	NN	NN	_	7	compound	_	_
5	tissue	tissue	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	cardiac	cardiac	JJ	JJ	_	11	amod	_	_
10	transplant	transplant	NN	NN	_	11	compound	_	_
11	recipients	recipient	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Fibrin	fibrin	NN	NN	_	4	compound	_	_
4	deposition	deposition	NN	NN	_	9	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	thrombosis	thrombosis	NN	NN	_	4	conj	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	implicated	implicate	VBN	VBN	_	1	dep	_	_
10	in	in	IN	IN	_	13	case	_	_
11	both	both	CC	CC	_	13	cc:preconj	_	_
12	allograft	allograft	NN	NN	_	13	compound	_	_
13	rejection	rejection	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	vasculopathy	vasculopathy	NN	NN	_	13	conj	_	_
16	after	after	IN	IN	_	18	case	_	_
17	cardiac	cardiac	JJ	JJ	_	18	amod	_	_
18	transplantation	transplantation	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Because	because	IN	IN	_	3	mark	_	_
2	monocytes	monocyte	NNS	NNS	_	3	nsubj	_	_
3	play	play	VBP	VBP	_	26	advcl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	pivotal	pivotal	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	pathophysiology	pathophysiology	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	intravascular	intravascular	JJ	JJ	_	13	amod	_	_
12	coagulation	coagulation	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	through	through	IN	IN	_	16	case	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	ability	ability	NN	NN	_	3	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	synthesize	synthesize	VB	VB	_	16	acl	_	_
19	tissue	tissue	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	18	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TF	tf	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	asked	ask	VBD	VBD	_	0	root	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	1	1	LS	LS	_	34	dep	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	whether	whether	IN	IN	_	34	mark	_	_
31	monocyte	monocyte	NN	NN	_	33	compound	_	_
32	TF	tf	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	34	nsubj	_	_
34	occurs	occur	VBZ	VBZ	_	26	dep	_	_
35	in	in	IN	IN	_	38	case	_	_
36	cardiac	cardiac	JJ	JJ	_	38	amod	_	_
37	transplant	transplant	NN	NN	_	38	compound	_	_
38	recipients	recipient	NNS	NNS	_	34	nmod	_	_
39	and	and	CC	CC	_	34	cc	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	2	2	LS	LS	_	48	dep	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	whether	whether	IN	IN	_	48	mark	_	_
44	monocyte	monocyte	NN	NN	_	46	compound	_	_
45	TF	tf	NN	NN	_	46	compound	_	_
46	expression	expression	NN	NN	_	48	nsubjpass	_	_
47	is	be	VBZ	VBZ	_	48	auxpass	_	_
48	affected	affect	VBN	VBN	_	34	conj	_	_
49	by	by	IN	IN	_	50	case	_	_
50	treatment	treatment	NN	NN	_	48	nmod	_	_
51	with	with	IN	IN	_	53	case	_	_
52	cyclosporin	cyclosporin	NN	NN	_	53	compound	_	_
53	A	a	NN	NN	_	50	nmod	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	CsA	csa	NN	NN	_	53	appos	_	_
56	)	)	-RRB-	-RRB-	_	55	punct	_	_
57	.	.	.	.	_	26	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	RESULTS	result	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	We	we	PRP	PRP	_	6	nsubj	_	_
6	measured	measure	VBD	VBD	_	1	dep	_	_
7	levels	level	NNS	NNS	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	TF	tf	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
13	blood	blood	NN	NN	_	15	compound	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	highly	highly	RB	RB	_	19	advmod	_	_
18	purified	purify	VBN	VBN	_	19	amod	_	_
19	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	15	conj	_	_
20	from	from	IN	IN	_	25	case	_	_
21	10	10	CD	CD	_	25	nummod	_	_
22	consecutive	consecutive	JJ	JJ	_	25	amod	_	_
23	cardiac	cardiac	JJ	JJ	_	25	amod	_	_
24	transplant	transplant	NN	NN	_	25	compound	_	_
25	recipients	recipient	NNS	NNS	_	15	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	10	10	CD	CD	_	30	nummod	_	_
28	healthy	healthy	JJ	JJ	_	30	amod	_	_
29	control	control	JJ	JJ	_	30	amod	_	_
30	subjects	subject	NNS	NNS	_	25	conj	_	_
31	.	.	.	.	_	1	punct	_	_

1	TF	tf	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	12	nsubj	_	_
3	generated	generate	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	6	case	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	unstimulated	unstimulated	JJ	JJ	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	endotoxin-stimulated	endotoxin-stimulated	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	conj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	higher	higher	JJR	JJR	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	transplant	transplant	NN	NN	_	15	compound	_	_
15	recipients	recipient	NNS	NNS	_	12	nmod	_	_
16	than	than	IN	IN	_	19	case	_	_
17	in	in	IN	IN	_	19	case	_	_
18	control	control	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	12	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	P	p	NN	NN	_	19	dep	_	_
22	&lt;	&lt;	JJR	JJR	_	21	amod	_	_
23	.05	.05	CD	CD	_	22	dep	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	.	.	.	.	_	12	punct	_	_

1	Increased	increase	VBN	VBN	_	4	amod	_	_
2	monocyte	monocyte	NN	NN	_	4	compound	_	_
3	TF	tf	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	9	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	transplant	transplant	NN	NN	_	7	compound	_	_
7	recipients	recipient	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	13	mark	_	_
11	be	be	VB	VB	_	13	auxpass	_	_
12	adversely	adversely	RB	RB	_	13	advmod	_	_
13	affected	affect	VBN	VBN	_	9	xcomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	treatment	treatment	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	CsA	csa	NN	NN	_	15	nmod	_	_
18	:	:	:	:	_	9	punct	_	_
19	TF	tf	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	23	nsubjpass	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	markedly	markedly	RB	RB	_	23	advmod	_	_
23	reduced	reduce	VBN	VBN	_	9	parataxis	_	_
24	by	by	IN	IN	_	27	case	_	_
25	CsA	csa	NN	NN	_	27	compound	_	_
26	serum	serum	NN	NN	_	27	compound	_	_
27	concentrations	concentration	NNS	NNS	_	23	nmod	_	_
28	reaching	reach	VBG	VBG	_	27	acl	_	_
29	peak	peak	JJ	JJ	_	32	amod	_	_
30	CsA	csa	NN	NN	_	32	compound	_	_
31	drug	drug	NN	NN	_	32	compound	_	_
32	levels	level	NNS	NNS	_	28	dobj	_	_
33	.	.	.	.	_	9	punct	_	_

1	Inhibition	inhibition	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	TF	tf	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	presence	presence	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	high	high	JJ	JJ	_	12	amod	_	_
10	CsA	csa	NN	NN	_	12	compound	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	concentrations	concentration	NNS	NNS	_	7	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	observed	observe	VBN	VBN	_	0	root	_	_
16	when	when	WRB	WRB	_	21	advmod	_	_
17	stimulation	stimulation	NN	NN	_	21	nsubjpass	_	_
18	of	of	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	performed	perform	VBN	VBN	_	15	advcl	_	_
22	with	with	IN	IN	_	23	case	_	_
23	interferon-gamma	interferon-gamma	NN	NN	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	interleukin-1beta	interleukin-1beta	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	15	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	shown	show	VBN	VBN	_	19	advcl	_	_
3	by	by	IN	IN	_	7	case	_	_
4	reverse	reverse	JJ	JJ	_	7	amod	_	_
5	transcription-polymerase	transcription-polymerase	NN	NN	_	7	compound	_	_
6	chain	chain	NN	NN	_	7	compound	_	_
7	reaction	reaction	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	electrophoretic	electrophoretic	JJ	JJ	_	12	amod	_	_
10	mobility	mobility	NN	NN	_	12	compound	_	_
11	shift	shift	NN	NN	_	12	compound	_	_
12	assay	assay	NN	NN	_	7	conj	_	_
13	,	,	,	,	_	2	punct	_	_
14	respectively	respectively	RB	RB	_	2	advmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	treatment	treatment	NN	NN	_	19	nsubj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	CsA	csa	NN	NN	_	16	nmod	_	_
19	leads	lead	VBZ	VBZ	_	0	root	_	_
20	to	to	TO	TO	_	24	case	_	_
21	decreased	decrease	VBN	VBN	_	24	amod	_	_
22	TF	tf	NN	NN	_	23	compound	_	_
23	mRNA	mrna	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	19	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	reduced	reduce	VBN	VBN	_	27	amod	_	_
27	activation	activation	NN	NN	_	24	conj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	32	compound	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factor	factor	NN	NN	_	27	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	which	which	WDT	WDT	_	36	nsubjpass	_	_
35	is	be	VBZ	VBZ	_	36	auxpass	_	_
36	known	know	VBN	VBN	_	32	acl:relcl	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	contribute	contribute	VB	VB	_	36	xcomp	_	_
39	to	to	TO	TO	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	induction	induction	NN	NN	_	38	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	TF	tf	NN	NN	_	45	compound	_	_
45	promotor	promotor	NN	NN	_	41	nmod	_	_
46	in	in	IN	IN	_	48	case	_	_
47	human	human	JJ	JJ	_	48	amod	_	_
48	monocytes	monocyte	NNS	NNS	_	41	nmod	_	_
49	.	.	.	.	_	19	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	This	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	5	nsubj	_	_
5	demonstrates	demonstrate	VBZ	VBZ	_	1	dep	_	_
6	that	that	IN	IN	_	20	mark	_	_
7	TF	tf	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	20	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	occurring	occur	VBG	VBG	_	8	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	cardiac	cardiac	JJ	JJ	_	17	amod	_	_
16	transplant	transplant	NN	NN	_	17	compound	_	_
17	recipients	recipient	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	inhibited	inhibit	VBN	VBN	_	5	ccomp	_	_
21	by	by	IN	IN	_	22	case	_	_
22	treatment	treatment	NN	NN	_	20	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	CsA	csa	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Inhibition	inhibition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	monocyte	monocyte	NN	NN	_	5	compound	_	_
4	TF	tf	NN	NN	_	5	compound	_	_
5	induction	induction	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	CsA	csa	NN	NN	_	1	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	contribute	contribute	VB	VB	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	successful	successful	JJ	JJ	_	13	amod	_	_
13	use	use	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	cardiac	cardiac	JJ	JJ	_	17	amod	_	_
16	transplant	transplant	NN	NN	_	17	compound	_	_
17	medicine	medicine	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	might	might	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	useful	useful	JJ	JJ	_	9	conj	_	_
22	in	in	IN	IN	_	23	mark	_	_
23	managing	manage	VBG	VBG	_	21	advcl	_	_
24	further	further	JJ	JJ	_	25	amod	_	_
25	settings	setting	NNS	NNS	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	vascular	vascular	JJ	JJ	_	28	amod	_	_
28	pathology	pathology	NN	NN	_	25	nmod	_	_
29	also	also	RB	RB	_	28	advmod	_	_
30	known	know	VBN	VBN	_	28	acl	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	involve	involve	VB	VB	_	30	xcomp	_	_
33	TF	tf	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	32	dobj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	NF-kappaB	nf-kappab	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	34	conj	_	_
38	.	.	.	.	_	9	punct	_	_

1	Agonistic	agonistic	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	CD40-specific	cd40-specific	JJ	JJ	_	7	amod	_	_
6	single-chain	single-chain	JJ	JJ	_	7	amod	_	_
7	Fv	fv	NN	NN	_	2	nmod	_	_
8	constructed	construct	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	variable	variable	JJ	JJ	_	12	amod	_	_
12	regions	region	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	mAb	mab	NN	NN	_	15	compound	_	_
15	G28-5	g28-5	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	single-chain	single-chain	JJ	JJ	_	3	amod	_	_
3	Fv	fv	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	sFv	sfv	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	0	root	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	variable	variable	JJ	JJ	_	12	amod	_	_
12	regions	region	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	CD40-specific	cd40-specific	JJ	JJ	_	17	amod	_	_
16	mAb	mab	NN	NN	_	17	compound	_	_
17	G28-5	g28-5	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	molecule	molecule	NN	NN	_	3	nsubj	_	_
3	bound	bind	VBD	VBD	_	0	root	_	_
4	CD40	cd40	NN	NN	_	3	dobj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	affinity	affinity	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	2.2	2.2	CD	CD	_	11	nummod	_	_
11	nM	nm	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	monomer	monomer	NN	NN	_	3	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	solution	solution	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	G28-5	g28-5	NN	NN	_	4	compound	_	_
4	sFv	sfv	NN	NN	_	9	nsubj	_	_
5	was	be	VBD	VBD	_	9	cop	_	_
6	a	a	DT	DT	_	9	det	_	_
7	potent	potent	JJ	JJ	_	9	amod	_	_
8	CD40	cd40	NN	NN	_	9	compound	_	_
9	agonist	agonist	NN	NN	_	0	root	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	rapidly	rapidly	RB	RB	_	12	advmod	_	_
12	crosslinked	crosslink	VBD	VBD	_	9	acl:relcl	_	_
13	CD40	cd40	NN	NN	_	12	dobj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	surface	surface	NN	NN	_	13	nmod	_	_
18	but	but	CC	CC	_	12	cc	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	crosslink	crosslink	VB	VB	_	12	conj	_	_
22	CD40-Ig	cd40-ig	NN	NN	_	21	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	solution	solution	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	G28-5	g28-5	NN	NN	_	2	compound	_	_
2	sFv	sfv	NN	NN	_	7	nsubj	_	_
3	was	be	VBD	VBD	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	potent	potent	JJ	JJ	_	7	amod	_	_
7	agonist	agonist	NN	NN	_	0	root	_	_
8	than	than	IN	IN	_	10	case	_	_
9	G28-5	g28-5	NN	NN	_	10	compound	_	_
10	IgG	igg	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	able	able	JJ	JJ	_	7	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	stimulate	stimulate	VB	VB	_	13	xcomp	_	_
16	CD40	cd40	NN	NN	_	17	compound	_	_
17	responses	response	NNS	NNS	_	15	dobj	_	_
18	by	by	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	monocytes	monocyte	NNS	NNS	_	20	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	G28-5	g28-5	NN	NN	_	2	compound	_	_
2	IgG	igg	NN	NN	_	4	nsubj	_	_
3	partially	partially	RB	RB	_	4	advmod	_	_
4	blocked	block	VBD	VBD	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	whereas	whereas	IN	IN	_	9	mark	_	_
7	G28-5	g28-5	NN	NN	_	8	compound	_	_
8	sFv	sfv	NN	NN	_	9	nsubj	_	_
9	augmented	augment	VBD	VBD	_	4	advcl	_	_
10	CD40	cd40	NN	NN	_	11	compound	_	_
11	responses	response	NNS	NNS	_	9	dobj	_	_
12	during	during	IN	IN	_	13	case	_	_
13	stimulation	stimulation	NN	NN	_	9	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	natural	natural	JJ	JJ	_	16	amod	_	_
16	ligand	ligand	NN	NN	_	13	nmod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	gp39-CD8	gp39-cd8	JJ	JJ	_	20	amod	_	_
19	fusion	fusion	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	19	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	ligands	ligand	NNS	NNS	_	7	nmod	_	_
10	built	build	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	site	site	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	G28-5	g28-5	NN	NN	_	14	nmod	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	highly	highly	RB	RB	_	19	advmod	_	_
19	dependent	dependent	JJ	JJ	_	3	ccomp	_	_
20	upon	upon	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	size	size	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	physical	physical	JJ	JJ	_	25	amod	_	_
25	properties	property	NNS	NNS	_	22	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	molecule	molecule	NN	NN	_	22	nmod	_	_
29	both	both	CC	CC	_	31	cc:preconj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	solution	solution	NN	NN	_	19	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	on	on	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	surfaces	surface	NNS	NNS	_	31	conj	_	_
37	.	.	.	.	_	3	punct	_	_

1	Competent	competent	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	initiation	initiation	NN	NN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	RNA	rna	NN	NN	_	6	compound	_	_
6	polymerase	polymerase	NN	NN	_	3	nmod	_	_
7	II	ii	CD	CD	_	6	nummod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	cell-free	cell-free	JJ	JJ	_	10	amod	_	_
10	extracts	extract	NNS	NNS	_	3	nmod	_	_
11	from	from	IN	IN	_	14	case	_	_
12	xeroderma	xeroderma	NN	NN	_	14	compound	_	_
13	pigmentosum	pigmentosum	NN	NN	_	14	compound	_	_
14	groups	group	NNS	NNS	_	10	nmod	_	_
15	B	b	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	D	d	NN	NN	_	14	conj	_	_
18	in	in	IN	IN	_	23	case	_	_
19	an	a	DT	DT	_	23	det	_	_
20	optimized	optimize	VBN	VBN	_	23	amod	_	_
21	RNA	rna	NN	NN	_	23	compound	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	assay	assay	NN	NN	_	3	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	autosomal	autosomal	JJ	JJ	_	5	amod	_	_
4	recessive	recessive	JJ	JJ	_	5	amod	_	_
5	disease	disease	NN	NN	_	14	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	xeroderma	xeroderma	NN	NN	_	8	compound	_	_
8	pigmentosum	pigmentosum	NN	NN	_	5	appos	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	XP	xp	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	5	punct	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	result	result	VB	VB	_	0	root	_	_
15	from	from	IN	IN	_	16	case	_	_
16	mutations	mutation	NNS	NNS	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	any	any	DT	DT	_	19	det	_	_
19	one	one	CD	CD	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	seven	seven	CD	CD	_	22	nummod	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	designated	designate	VBN	VBN	_	22	acl	_	_
25	XPA	xpa	NN	NN	_	24	xcomp	_	_
26	through	through	IN	IN	_	27	case	_	_
27	XPG	xpg	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	Of	of	IN	IN	_	2	case	_	_
2	these	these	DT	DT	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	XPB	xpb	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	XPD	xpd	NN	NN	_	5	conj	_	_
8	genes	gene	NNS	NNS	_	5	dep	_	_
9	encode	encode	VBP	VBP	_	0	root	_	_
10	proteins	protein	NNS	NNS	_	9	dobj	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	subunits	subunit	NNS	NNS	_	10	acl:relcl	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	general	general	JJ	JJ	_	18	amod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	TFIIH	tfiih	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	13	punct	_	_
22	involved	involve	VBN	VBN	_	13	acl	_	_
23	in	in	IN	IN	_	27	case	_	_
24	both	both	CC	CC	_	27	cc:preconj	_	_
25	nucleotide	nucleotide	NN	NN	_	27	compound	_	_
26	excision	excision	NN	NN	_	27	compound	_	_
27	repair	repair	NN	NN	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	NER	ner	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	initiation	initiation	NN	NN	_	27	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	transcription	transcription	NN	NN	_	32	nmod	_	_
36	by	by	IN	IN	_	38	case	_	_
37	RNA	rna	NN	NN	_	38	compound	_	_
38	polymerase	polymerase	NN	NN	_	27	nmod	_	_
39	II	ii	CD	CD	_	38	nummod	_	_
40	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	humans	human	NNS	NNS	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	mutation	mutation	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	XPB	xpb	NN	NN	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	XPD	xpd	NN	NN	_	7	conj	_	_
10	gene	gene	NN	NN	_	7	dep	_	_
11	impairs	impair	VBZ	VBZ	_	0	root	_	_
12	NER	ner	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	11	punct	_	_
14	resulting	result	VBG	VBG	_	11	advcl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	hyper-sensitivity	hyper-sensitivity	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	sunlight	sunlight	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	greatly	greatly	RB	RB	_	21	advmod	_	_
21	increased	increase	VBN	VBN	_	24	amod	_	_
22	skin	skin	NN	NN	_	24	compound	_	_
23	tumor	tumor	NN	NN	_	24	compound	_	_
24	formation	formation	NN	NN	_	16	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	deficiency	deficiency	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	either	either	CC	CC	_	11	cc:preconj	_	_
11	XP-B	xp-b	NN	NN	_	8	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	XP-D	xp-d	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	employed	employ	VBN	VBN	_	0	root	_	_
4	an	a	DT	DT	_	9	det	_	_
5	optimized	optimize	VBN	VBN	_	9	amod	_	_
6	cell-free	cell-free	JJ	JJ	_	9	amod	_	_
7	RNA	rna	NN	NN	_	9	compound	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	assay	assay	NN	NN	_	3	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	analyze	analyze	VB	VB	_	3	xcomp	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	XP-B	xp-b	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	XP-D	xp-d	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	growth	growth	NN	NN	_	4	compound	_	_
4	rate	rate	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	normal	normal	JJ	JJ	_	13	advcl	_	_
7	,	,	,	,	_	13	punct	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	XP-B	xp-b	NN	NN	_	13	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	XP-D	xp-d	NN	NN	_	9	conj	_	_
12	cells	cell	NNS	NNS	_	9	dep	_	_
13	contained	contain	VBD	VBD	_	0	root	_	_
14	reduced	reduce	VBN	VBN	_	15	amod	_	_
15	amounts	amount	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	TFIIH	tfiih	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	Extracts	extract	NNS	NNS	_	9	nsubj	_	_
2	prepared	prepare	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	4	case	_	_
4	XP-B	xp-b	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	XP-D	xp-d	NN	NN	_	4	conj	_	_
7	lymphoblastoid	lymphoblastoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	dep	_	_
9	exhibited	exhibit	VBD	VBD	_	0	root	_	_
10	similar	similar	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	from	from	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	adenovirus	adenovirus	NN	NN	_	18	compound	_	_
16	major	major	JJ	JJ	_	18	amod	_	_
17	late	late	JJ	JJ	_	18	amod	_	_
18	promoter	promoter	NN	NN	_	12	nmod	_	_
19	when	when	WRB	WRB	_	20	advmod	_	_
20	compared	compare	VBN	VBN	_	9	advcl	_	_
21	to	to	TO	TO	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	extracts	extract	NNS	NNS	_	22	nmod	_	_
25	from	from	IN	IN	_	27	case	_	_
26	normal	normal	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	conclude	conclude	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	XP-B	xp-b	NN	NN	_	14	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	XP-D	xp-d	NN	NN	_	7	conj	_	_
10	lymphoblastoid	lymphoblastoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	dep	_	_
12	do	do	VBP	VBP	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	have	have	VB	VB	_	4	ccomp	_	_
15	impaired	impaired	JJ	JJ	_	18	amod	_	_
16	RNA	rna	NN	NN	_	18	compound	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	consider	consider	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	possible	possible	JJ	JJ	_	5	amod	_	_
5	consequences	consequence	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	reduced	reduce	VBN	VBN	_	10	amod	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	content	content	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TFIIH	tfiih	NN	NN	_	10	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	clinical	clinical	JJ	JJ	_	16	amod	_	_
16	symptoms	symptom	NNS	NNS	_	2	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	XP-B	xp-b	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	XP-D	xp-d	NN	NN	_	18	conj	_	_
21	patients	patient	NNS	NNS	_	18	dep	_	_
22	,	,	,	,	_	2	punct	_	_
23	and	and	CC	CC	_	2	cc	_	_
24	discuss	discuss	VBP	VBP	_	2	conj	_	_
25	a	a	DT	DT	_	28	det	_	_
26	'	'	``	``	_	28	punct	_	_
27	conditional	conditional	JJ	JJ	_	28	amod	_	_
28	phenotype	phenotype	NN	NN	_	24	dobj	_	_
29	'	'	''	''	_	28	punct	_	_
30	that	that	WDT	WDT	_	32	nsubj	_	_
31	may	may	MD	MD	_	32	aux	_	_
32	involve	involve	VB	VB	_	28	acl:relcl	_	_
33	an	a	DT	DT	_	34	det	_	_
34	impairment	impairment	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	cellular	cellular	JJ	JJ	_	37	amod	_	_
37	function	function	NN	NN	_	34	nmod	_	_
38	only	only	RB	RB	_	42	advmod	_	_
39	under	under	IN	IN	_	42	case	_	_
40	certain	certain	JJ	JJ	_	42	amod	_	_
41	growth	growth	NN	NN	_	42	compound	_	_
42	conditions	condition	NNS	NNS	_	32	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	early	early	JJ	JJ	_	6	amod	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	G0/G1	g0/g1	NN	NN	_	10	compound	_	_
9	switch	switch	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	2	2	CD	CD	_	10	nummod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	G0S2	g0s2	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	20	case	_	_
16	cultured	culture	VBN	VBN	_	20	amod	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	blood	blood	NN	NN	_	20	compound	_	_
19	mononuclear	mononuclear	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	6	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CsA	csa	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	achieve	achieve	VB	VB	_	0	root	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	immunosuppressive	immunosuppressive	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	7	dobj	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	inhibiting	inhibit	VBG	VBG	_	7	advcl	_	_
13	the	the	DT	DT	_	17	det	_	_
14	calcium-	calcium-	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	calmodulin-dependent	calmodulin-dependent	JJ	JJ	_	14	conj	_	_
17	phosphatase	phosphatase	NN	NN	_	12	dobj	_	_
18	calcineurin	calcineurin	NN	NN	_	17	dep	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	17	acl:relcl	_	_
22	for	for	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	target	target	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	23	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	members	member	NNS	NNS	_	23	nmod	_	_
29	of	of	IN	IN	_	42	case	_	_
30	the	the	DT	DT	_	42	det	_	_
31	NFAT	nfat	NN	NN	_	42	compound	_	_
32	(	(	-LRB-	-LRB-	_	42	punct	_	_
33	nuclear	nuclear	JJ	JJ	_	42	amod	_	_
34	factor	factor	NN	NN	_	42	compound	_	_
35	of	of	IN	IN	_	42	amod	_	_
36	activated	activate	VBN	VBN	_	42	amod	_	_
37	T	t	NN	NN	_	42	compound	_	_
38	cells	cell	NNS	NNS	_	42	compound	_	_
39	)	)	-RRB-	-RRB-	_	42	punct	_	_
40	transcription	transcription	NN	NN	_	42	compound	_	_
41	factor	factor	NN	NN	_	42	compound	_	_
42	family	family	NN	NN	_	28	nmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	Among	among	IN	IN	_	4	case	_	_
2	these	these	DT	DT	_	4	det	_	_
3	target	target	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	5	nmod	_	_
5	is	be	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	gene	gene	NN	NN	_	5	dep	_	_
8	encoding	encode	VBG	VBG	_	7	acl	_	_
9	interleukin-2	interleukin-2	NN	NN	_	8	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL2	il2	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	a	a	DT	DT	_	15	det	_	_
15	cytokine	cytokine	NN	NN	_	9	appos	_	_
16	facilitating	facilitate	VBG	VBG	_	15	acl	_	_
17	progression	progression	NN	NN	_	16	dobj	_	_
18	through	through	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	G1	g1	NN	NN	_	21	compound	_	_
21	phase	phase	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	cycle	cycle	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	IL2	il2	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	reverse	reverse	VB	VB	_	0	root	_	_
7	CsA	csa	NN	NN	_	8	compound	_	_
8	inhibition	inhibition	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
11	that	that	IN	IN	_	20	mark	_	_
12	at	at	IN	IN	_	13	case	_	_
13	least	least	JJS	JJS	_	14	nmod:npmod	_	_
14	one	one	CD	CD	_	17	nummod	_	_
15	other	other	JJ	JJ	_	17	amod	_	_
16	NFAT-sensitive	nfat-sensitive	JJ	JJ	_	17	amod	_	_
17	gene	gene	NN	NN	_	20	nsubjpass	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	involved	involve	VBN	VBN	_	10	ccomp	_	_
21	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	G0/G1	g0/g1	NN	NN	_	5	compound	_	_
4	switch	switch	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	9	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	G0S2	g0s2	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	potential	potential	JJ	JJ	_	12	amod	_	_
11	NFAT-binding	nfat-binding	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	9	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	5'	5'	JJ	JJ	_	16	amod	_	_
16	flank	flank	NN	NN	_	9	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	encodes	encode	VBZ	VBZ	_	9	conj	_	_
19	a	a	DT	DT	_	23	det	_	_
20	small	small	JJ	JJ	_	23	amod	_	_
21	basic	basic	JJ	JJ	_	23	amod	_	_
22	potential	potential	JJ	JJ	_	23	amod	_	_
23	phosphoprotein	phosphoprotein	NN	NN	_	18	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	unknown	unknown	JJ	JJ	_	26	amod	_	_
26	function	function	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	12	det	_	_
3	sensitive	sensitive	JJ	JJ	_	12	amod	_	_
4	,	,	,	,	_	12	punct	_	_
5	reverse	reverse	JJ	JJ	_	8	amod	_	_
6	transcription-polymerase	transcription-polymerase	NN	NN	_	8	compound	_	_
7	chain	chain	NN	NN	_	8	compound	_	_
8	reaction	reaction	NN	NN	_	12	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	RT-PCR	rt-pcr	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	assay	assay	NN	NN	_	1	dobj	_	_
13	,	,	,	,	_	1	punct	_	_
14	G0S2	g0s2	NN	NN	_	16	compound	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	assayed	assay	VBN	VBN	_	1	parataxis	_	_
19	in	in	IN	IN	_	23	case	_	_
20	cultured	culture	VBN	VBN	_	23	amod	_	_
21	blood	blood	NN	NN	_	23	compound	_	_
22	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	Freshly	freshly	RB	RB	_	2	advmod	_	_
2	isolated	isolate	VBN	VBN	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	contain	contain	VBP	VBP	_	0	root	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	G0S2	g0s2	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	6	nmod	_	_
10	which	which	WDT	WDT	_	12	nsubj	_	_
11	rapidly	rapidly	RB	RB	_	12	advmod	_	_
12	decline	decline	VBP	VBP	_	6	acl:relcl	_	_
13	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	``	``	``	``	_	4	punct	_	_
3	spontaneous	spontaneous	JJ	JJ	_	4	amod	_	_
4	stimulation	stimulation	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	noted	note	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	12	case	_	_
9	some	some	DT	DT	_	12	det	_	_
10	other	other	JJ	JJ	_	12	amod	_	_
11	G0S	g0s	NN	NN	_	12	compound	_	_
12	genes	gene	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	attributed	attribute	VBN	VBN	_	7	conj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	some	some	DT	DT	_	19	det	_	_
19	aspect	aspect	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	isolation	isolation	NN	NN	_	23	compound	_	_
23	procedure	procedure	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	cells	cell	NNS	NNS	_	13	nmod	_	_
3	that	that	WDT	WDT	_	6	nsubjpass	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	preincubated	preincubate	VBN	VBN	_	2	acl:relcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	lower	lower	VB	VB	_	6	dep	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	there	there	EX	EX	_	13	expl	_	_
13	is	be	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	transient	transient	JJ	JJ	_	16	amod	_	_
16	increase	increase	NN	NN	_	13	nsubj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	G0S2	g0s2	NN	NN	_	19	compound	_	_
19	mRNA	mrna	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	16	punct	_	_
21	peaking	peak	VBG	VBG	_	16	acl	_	_
22	between	between	IN	IN	_	24	case	_	_
23	1-2	1-2	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	16	punct	_	_
26	in	in	IN	IN	_	27	case	_	_
27	response	response	NN	NN	_	16	nmod	_	_
28	to	to	TO	TO	_	29	case	_	_
29	Concanavalin-A	concanavalin-a	NN	NN	_	27	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	ConA	cona	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	29	punct	_	_
34	or	or	CC	CC	_	29	cc	_	_
35	to	to	TO	TO	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	combination	combination	NN	NN	_	29	conj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	phorbol	phorbol	NN	NN	_	40	compound	_	_
40	ester	ester	NN	NN	_	37	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	TPA	tpa	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	,	,	,	,	_	40	punct	_	_
45	and	and	CC	CC	_	40	cc	_	_
46	the	the	DT	DT	_	48	det	_	_
47	calcium	calcium	NN	NN	_	48	compound	_	_
48	ionophore	ionophore	NN	NN	_	40	conj	_	_
49	,	,	,	,	_	48	punct	_	_
50	ionomycin	ionomycin	NN	NN	_	48	appos	_	_
51	.	.	.	.	_	13	punct	_	_

1	Both	both	PDT	PDT	_	3	det:predet	_	_
2	these	these	DT	DT	_	3	det	_	_
3	responses	response	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	CsA	csa	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	G0S2	g0s2	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	3	ccomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	commit	commit	VB	VB	_	8	xcomp	_	_
11	cells	cell	NNS	NNS	_	10	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	enter	enter	VB	VB	_	10	xcomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	G1	g1	NN	NN	_	16	compound	_	_
16	phase	phase	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	cycle	cycle	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	that	that	IN	IN	_	41	mark	_	_
24	,	,	,	,	_	41	punct	_	_
25	while	while	IN	IN	_	27	mark	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	excluding	exclude	VBG	VBG	_	41	advcl	_	_
28	other	other	DT	DT	_	30	det	_	_
29	possible	possible	JJ	JJ	_	30	amod	_	_
30	targets	target	NNS	NNS	_	27	dobj	_	_
31	,	,	,	,	_	41	punct	_	_
32	early	early	JJ	JJ	_	33	amod	_	_
33	inhibition	inhibition	NN	NN	_	41	nsubj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	G0S2	g0s2	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	33	nmod	_	_
37	by	by	IN	IN	_	38	case	_	_
38	CsA	csa	NN	NN	_	33	nmod	_	_
39	may	may	MD	MD	_	41	aux	_	_
40	be	be	VB	VB	_	41	cop	_	_
41	important	important	JJ	JJ	_	8	conj	_	_
42	in	in	IN	IN	_	43	mark	_	_
43	achieving	achieve	VBG	VBG	_	41	advcl	_	_
44	immunosuppression	immunosuppression	NN	NN	_	43	dobj	_	_
45	.	.	.	.	_	3	punct	_	_

1	G0S2	g0s2	NN	NN	_	5	nsubj	_	_
2	may	may	MD	MD	_	5	aux	_	_
3	be	be	VB	VB	_	5	cop	_	_
4	of	of	IN	IN	_	5	case	_	_
5	value	value	NN	NN	_	0	root	_	_
6	as	as	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	analyzing	analyze	VBG	VBG	_	9	acl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	mechanism	mechanism	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	action	action	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CsA	csa	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	influence	influence	NN	NN	_	13	conj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	positive	positive	JJ	JJ	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	negative	negative	JJ	JJ	_	23	conj	_	_
26	selection	selection	NN	NN	_	23	dep	_	_
27	of	of	IN	IN	_	28	case	_	_
28	lymphocytes	lymphocyte	NNS	NNS	_	23	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	response	response	NN	NN	_	23	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	self	self	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	not-self	not-self	JJ	JJ	_	32	conj	_	_
35	antigens	antigen	NNS	NNS	_	32	dep	_	_
36	.	.	.	.	_	5	punct	_	_

1	Estrogen	estrogen	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	3	nsubj	_	_
3	diminishes	diminish	VBZ	VBZ	_	0	root	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	activities	activity	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	chicken	chicken	NN	NN	_	8	compound	_	_
8	GATA-1	gata-1	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CACCC-binding	caccc-binding	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	8	conj	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	estrogen	estrogen	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	ER	er	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	repressed	repress	VBD	VBD	_	0	root	_	_
8	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	erythroid-specific	erythroid-specific	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	conj	_	_
14	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	ER	er	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	referred	refer	VBN	VBN	_	11	dep	_	_
14	to	to	TO	TO	_	13	nmod	_	_
15	throughout	throughout	RB	RB	_	13	advmod	_	_
16	as	as	IN	IN	_	17	case	_	_
17	ER	er	NN	NN	_	13	nmod	_	_
18	)	)	-RRB-	-RRB-	_	13	punct	_	_
19	on	on	IN	IN	_	21	case	_	_
20	DNA-binding	dna-binding	JJ	JJ	_	21	amod	_	_
21	activities	activity	NNS	NNS	_	8	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	involved	involve	VBN	VBN	_	24	acl	_	_
26	in	in	IN	IN	_	27	mark	_	_
27	regulating	regulate	VBG	VBG	_	25	advcl	_	_
28	the	the	DT	DT	_	29	det	_	_
29	expression	expression	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	erythroid-specific	erythroid-specific	JJ	JJ	_	32	amod	_	_
32	genes	gene	NNS	NNS	_	29	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	and	and	CC	CC	_	32	cc	_	_
35	,	,	,	,	_	32	punct	_	_
36	in	in	IN	IN	_	37	case	_	_
37	particular	particular	JJ	JJ	_	32	conj	_	_
38	,	,	,	,	_	32	punct	_	_
39	the	the	DT	DT	_	42	det	_	_
40	histone	histone	NN	NN	_	42	compound	_	_
41	H5	h5	NN	NN	_	42	compound	_	_
42	gene	gene	NN	NN	_	32	conj	_	_
43	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	found	find	VBD	VBD	_	1	parataxis	_	_
9	that	that	IN	IN	_	20	mark	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	20	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	rabbit	rabbit	NN	NN	_	16	compound	_	_
15	reticulocyte	reticulocyte	NN	NN	_	16	compound	_	_
16	lysate	lysate	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	ER	er	NN	NN	_	20	nsubj	_	_
20	reduced	reduce	VBD	VBD	_	8	ccomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	activities	activity	NNS	NNS	_	20	dobj	_	_
24	of	of	IN	IN	_	30	case	_	_
25	chicken	chicken	NN	NN	_	30	compound	_	_
26	immature	immature	JJ	JJ	_	30	amod	_	_
27	erythrocyte	erythrocyte	NN	NN	_	30	compound	_	_
28	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
29	extracted	extracted	JJ	JJ	_	30	amod	_	_
30	proteins	protein	NNS	NNS	_	23	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	GATA	gata	NN	NN	_	23	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	CACCC	caccc	NN	NN	_	32	conj	_	_
35	sites	site	NNS	NNS	_	32	dep	_	_
36	in	in	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	H5	h5	NN	NN	_	32	nmod	_	_
39	promoter	promoter	NN	NN	_	38	dep	_	_
40	and	and	CC	CC	_	38	cc	_	_
41	enhancer	enhancer	NN	NN	_	38	conj	_	_
42	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activities	activity	NNS	NNS	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF1	nf1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Sp1	sp1	NN	NN	_	8	conj	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affected	affect	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	ER	er	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	Binding	binding	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ER	er	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	8	case	_	_
5	an	a	DT	DT	_	8	det	_	_
6	estrogen	estrogen	NN	NN	_	8	compound	_	_
7	response	response	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	1	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	enhanced	enhance	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	addition	addition	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	rabbit	rabbit	NN	NN	_	16	compound	_	_
15	reticulocyte	reticulocyte	NN	NN	_	16	compound	_	_
16	lysate	lysate	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	lysate	lysate	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	necessary	necessary	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	9	mark	_	_
7	ER	er	NN	NN	_	9	nsubj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	diminish	diminish	VB	VB	_	5	ccomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	DNA-binding	dna-binding	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GATA-1	gata-1	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	additional	additional	JJ	JJ	_	8	amod	_	_
6	factor	factor	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	11	nsubj	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	15	case	_	_
13	full	full	JJ	JJ	_	15	amod	_	_
14	ER	er	NN	NN	_	15	compound	_	_
15	function	function	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	GATA-1	gata-1	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CACCC-binding	caccc-binding	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	2	conj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	critical	critical	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	developmentally	developmentally	RB	RB	_	11	advmod	_	_
11	regulated	regulate	VBN	VBN	_	12	amod	_	_
12	expression	expression	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	erythroid-specific	erythroid-specific	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesize	hypothesize	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	interference	interference	NN	NN	_	15	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	activities	activity	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GATA-1	gata-1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CACCC-binding	caccc-binding	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	9	conj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mechanism	mechanism	NN	NN	_	2	ccomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	20	nmod	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ER	er	NN	NN	_	20	nsubj	_	_
20	inhibits	inhibit	VBZ	VBZ	_	15	acl:relcl	_	_
21	regulation	regulation	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	genes	gene	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	HLA	hla	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	characteristics	characteristic	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	generation	generation	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cytotoxic	cytotoxic	JJ	JJ	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	against	against	IN	IN	_	10	case	_	_
10	peptides	peptide	NNS	NNS	_	8	nmod	_	_
11	derived	derive	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	14	case	_	_
13	oncogenic	oncogenic	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	AIMS	aim	NNS	NNS	_	19	nsubjpass	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	BACKGROUND	background	NN	NN	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Structurally	structurally	RB	RB	_	6	advmod	_	_
6	altered	alter	VBN	VBN	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	19	nsubjpass	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	derived	derive	VBN	VBN	_	7	dep	_	_
10	from	from	IN	IN	_	12	case	_	_
11	chromosomal	chromosomal	JJ	JJ	_	12	amod	_	_
12	translocations	translocation	NNS	NNS	_	9	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	mutations	mutation	NNS	NNS	_	12	conj	_	_
16	)	)	-RRB-	-RRB-	_	9	punct	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	considered	consider	VBN	VBN	_	0	root	_	_
20	tumor	tumor	NN	NN	_	22	compound	_	_
21	specific	specific	JJ	JJ	_	22	amod	_	_
22	antigens	antigen	NNS	NNS	_	19	xcomp	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	represent	represent	VB	VB	_	19	conj	_	_
25	an	a	DT	DT	_	27	det	_	_
26	attractive	attractive	JJ	JJ	_	27	amod	_	_
27	target	target	NN	NN	_	24	dobj	_	_
28	for	for	IN	IN	_	32	case	_	_
29	a	a	DT	DT	_	32	det	_	_
30	T-cell	t-cell	NN	NN	_	32	compound	_	_
31	mediated	mediated	JJ	JJ	_	32	amod	_	_
32	response	response	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	19	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	3	nsubj	_	_
3	recognize	recognize	VBP	VBP	_	0	root	_	_
4	antigens	antigen	NNS	NNS	_	3	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	form	form	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	peptides	peptide	NNS	NNS	_	7	nmod	_	_
10	bound	bind	VBN	VBN	_	9	acl	_	_
11	to	to	TO	TO	_	12	case	_	_
12	HLA-molecules	hla-molecule	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	MATERIALS	material	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Peptides	peptide	NNS	NNS	_	11	nsubjpass	_	_
6	derived	derive	VBN	VBN	_	5	acl	_	_
7	from	from	IN	IN	_	9	case	_	_
8	oncogenic	oncogenic	JJ	JJ	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	screened	screen	VBN	VBN	_	1	dep	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	HLA	hla	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	motifs	motif	NNS	NNS	_	14	nmod	_	_
19	;	;	:	:	_	11	punct	_	_
20	actual	actual	JJ	JJ	_	21	amod	_	_
21	binding	binding	NN	NN	_	23	nsubjpass	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	evaluated	evaluate	VBN	VBN	_	11	parataxis	_	_
24	by	by	IN	IN	_	27	case	_	_
25	HLA	hla	NN	NN	_	27	compound	_	_
26	stabilization	stabilization	NN	NN	_	27	compound	_	_
27	experiments	experiment	NNS	NNS	_	23	nmod	_	_
28	using	use	VBG	VBG	_	23	xcomp	_	_
29	transfectants	transfectant	NNS	NNS	_	28	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	specific	specific	JJ	JJ	_	33	amod	_	_
32	anti-HLA	anti-hla	JJ	JJ	_	33	amod	_	_
33	antibodies	antibody	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	1	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	induced	induce	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	in	in	FW	FW	_	9	amod	_	_
7	vitro	vitro	FW	FW	_	6	dep	_	_
8	peptide	peptide	NN	NN	_	9	compound	_	_
9	sensitization	sensitization	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	screened	screen	VBN	VBN	_	4	conj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	thymidine	thymidine	NN	NN	_	14	compound	_	_
14	uptake	uptake	NN	NN	_	11	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	cellular	cellular	JJ	JJ	_	18	amod	_	_
17	cytotoxic	cytotoxic	JJ	JJ	_	18	amod	_	_
18	assays	assay	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	identified	identify	VBD	VBD	_	1	dep	_	_
5	peptides	peptide	NNS	NNS	_	4	dobj	_	_
6	derived	derive	VBN	VBN	_	5	acl	_	_
7	from	from	IN	IN	_	10	case	_	_
8	EWS/FLI-1	ews/fli-1	NN	NN	_	10	compound	_	_
9	fusion	fusion	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	advcl	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	from	from	IN	IN	_	15	case	_	_
13	mutated	mutate	VBN	VBN	_	15	amod	_	_
14	K-RAS	k-ras	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	10	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	encompassing	encompass	VBG	VBG	_	10	dep	_	_
18	respectively	respectively	RB	RB	_	17	advmod	_	_
19	the	the	DT	DT	_	21	det	_	_
20	fusion	fusion	NN	NN	_	21	compound	_	_
21	point	point	NN	NN	_	17	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	mutation	mutation	NN	NN	_	21	conj	_	_
25	at	at	IN	IN	_	26	case	_	_
26	position	position	NN	NN	_	24	nmod	_	_
27	12	12	CD	CD	_	26	nummod	_	_
28	)	)	-RRB-	-RRB-	_	17	punct	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	showed	show	VBD	VBD	_	5	acl:relcl	_	_
31	binding	bind	VBG	VBG	_	32	amod	_	_
32	motif	motif	NN	NN	_	30	dobj	_	_
33	for	for	IN	IN	_	34	case	_	_
34	HLA-Cw*0702	hla-cw*0702	NN	NN	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	HLA-A3	hla-a3	NN	NN	_	34	conj	_	_
37	respectively	respectively	RB	RB	_	30	advmod	_	_
38	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	actual	actual	JJ	JJ	_	3	amod	_	_
3	binding	binding	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	peptides	peptide	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	analysed	analyse	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	stabilization	stabilization	NN	NN	_	12	compound	_	_
12	assay	assay	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	detected	detect	VBD	VBD	_	0	root	_	_
3	binding	binding	NN	NN	_	2	dobj	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	EWS/FLI-1	ews/fli-1	NN	NN	_	7	compound	_	_
7	peptide	peptide	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	for	for	IN	IN	_	12	case	_	_
10	5	5	CD	CD	_	12	nummod	_	_
11	RAS	ras	NN	NN	_	12	compound	_	_
12	peptides	peptide	NNS	NNS	_	7	conj	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	1	1	CD	CD	_	16	nummod	_	_
15	wild	wild	JJ	JJ	_	16	amod	_	_
16	type	type	NN	NN	_	12	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	4	4	CD	CD	_	16	conj	_	_
19	mutated	mutate	VBN	VBN	_	18	amod	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	30	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	temperature	temperature	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	beta	beta	NN	NN	_	7	compound	_	_
7	2-microglobulin	2-microglobulin	NN	NN	_	4	conj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	beta	beta	NN	NN	_	10	compound	_	_
10	2-m	2-m	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	fetal	fetal	JJ	JJ	_	15	amod	_	_
14	calf	calf	NN	NN	_	15	compound	_	_
15	serum	serum	NN	NN	_	4	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	FCS	fcs	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	binding	binding	NN	NN	_	2	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	stability	stability	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	HLA/peptide	hla/peptide	NN	NN	_	28	compound	_	_
28	complex	complex	NN	NN	_	21	nmod	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	studied	study	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	low	low	JJ	JJ	_	3	amod	_	_
3	temperature	temperature	NN	NN	_	9	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	26	26	CD	CD	_	7	nummod	_	_
6	degrees	degree	NNS	NNS	_	7	compound	_	_
7	C	c	NN	NN	_	3	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	increased	increase	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	binding	binding	NN	NN	_	9	dobj	_	_
12	both	both	CC	CC	_	14	dep	_	_
13	in	in	IN	IN	_	14	case	_	_
14	HLA-A3	hla-a3	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	HLA-Cw*0702	hla-cw*0702	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	while	while	IN	IN	_	20	mark	_	_
19	FCS	fcs	NN	NN	_	20	nsubj	_	_
20	reduced	reduce	VBD	VBD	_	9	advcl	_	_
21	it	it	PRP	PRP	_	20	dobj	_	_
22	.	.	.	.	_	9	punct	_	_

1	beta	beta	NN	NN	_	2	compound	_	_
2	2-m	2-m	NN	NN	_	3	nsubj	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HLA-A3	hla-a3	NN	NN	_	9	compound	_	_
9	molecule	molecule	NN	NN	_	5	nmod	_	_
10	but	but	CC	CC	_	3	cc	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	influence	influence	VB	VB	_	3	conj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	HLA-Cw*0702	hla-cw*0702	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	stability	stability	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	already	already	RB	RB	_	2	nmod	_	_
5	formed	form	VBN	VBN	_	4	amod	_	_
6	complexed	complex	VBN	VBN	_	4	amod	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	somewhat	somewhat	RB	RB	_	9	advmod	_	_
9	different	different	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	dep	_	_
12	HLA-A3	hla-a3	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	HLA-Cw*0702	hla-cw*0702	NN	NN	_	12	conj	_	_
15	system	system	NN	NN	_	12	dep	_	_
16	:	:	:	:	_	9	punct	_	_
17	both	both	DT	DT	_	20	nsubj	_	_
18	were	be	VBD	VBD	_	20	cop	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	stable	stable	JJ	JJ	_	9	parataxis	_	_
21	at	at	IN	IN	_	24	case	_	_
22	26	26	CD	CD	_	24	nummod	_	_
23	degrees	degree	NNS	NNS	_	24	compound	_	_
24	C	c	NN	NN	_	20	nmod	_	_
25	than	than	IN	IN	_	29	case	_	_
26	at	at	IN	IN	_	29	case	_	_
27	37	37	CD	CD	_	29	nummod	_	_
28	degrees	degree	NNS	NNS	_	29	compound	_	_
29	C	c	NN	NN	_	20	nmod	_	_
30	but	but	CC	CC	_	20	cc	_	_
31	while	while	IN	IN	_	39	mark	_	_
32	the	the	DT	DT	_	34	dep	_	_
33	beta	beta	NN	NN	_	34	compound	_	_
34	2-m	2-m	NN	NN	_	39	nsubj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	FCS	fcs	NN	NN	_	34	conj	_	_
37	did	do	VBD	VBD	_	39	aux	_	_
38	not	not	RB	RB	_	39	neg	_	_
39	influence	influence	VB	VB	_	48	advcl	_	_
40	the	the	DT	DT	_	41	det	_	_
41	stability	stability	NN	NN	_	39	dobj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	HLA-A3/peptide	hla-a3/peptide	NN	NN	_	45	compound	_	_
45	complex	complex	NN	NN	_	41	nmod	_	_
46	,	,	,	,	_	48	punct	_	_
47	they	they	PRP	PRP	_	48	nsubj	_	_
48	seemed	seem	VBD	VBD	_	20	conj	_	_
49	to	to	TO	TO	_	50	mark	_	_
50	cause	cause	VB	VB	_	48	xcomp	_	_
51	opposite	opposite	JJ	JJ	_	52	amod	_	_
52	effects	effect	NNS	NNS	_	50	dobj	_	_
53	in	in	IN	IN	_	56	case	_	_
54	the	the	DT	DT	_	56	det	_	_
55	HLA-Cw*0702	hla-cw*0702	NN	NN	_	56	compound	_	_
56	system	system	NN	NN	_	50	nmod	_	_
57	(	(	-LRB-	-LRB-	_	60	punct	_	_
58	beta	beta	NN	NN	_	59	compound	_	_
59	2-m	2-m	NN	NN	_	60	nsubj	_	_
60	stabilized	stabilize	VBD	VBD	_	48	dep	_	_
61	and	and	CC	CC	_	60	cc	_	_
62	FCS	fcs	NN	NN	_	63	nsubj	_	_
63	destabilized	destabilize	VBD	VBD	_	60	conj	_	_
64	the	the	DT	DT	_	65	det	_	_
65	complex	complex	NN	NN	_	63	dobj	_	_
66	)	)	-RRB-	-RRB-	_	60	punct	_	_
67	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	generate	generate	VB	VB	_	5	xcomp	_	_
8	a	a	DT	DT	_	12	det	_	_
9	specific	specific	JJ	JJ	_	12	amod	_	_
10	CD8+	cd8+	JJ	JJ	_	12	amod	_	_
11	CTL	ctl	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	7	dobj	_	_
13	against	against	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	K-RAS	k-ras	NN	NN	_	17	compound	_	_
16	mutated	mutated	JJ	JJ	_	17	amod	_	_
17	peptide	peptide	NN	NN	_	7	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Although	although	IN	IN	_	12	mark	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	motifs	motif	NNS	NNS	_	12	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	actual	actual	JJ	JJ	_	9	amod	_	_
8	HLA	hla	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	5	conj	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	24	advcl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	several	several	JJ	JJ	_	15	amod	_	_
15	cases	case	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	24	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	generation	generation	NN	NN	_	24	nsubj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	cellular	cellular	JJ	JJ	_	22	amod	_	_
22	response	response	NN	NN	_	18	nmod	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	infrequent	infrequent	JJ	JJ	_	1	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	confirming	confirm	VBG	VBG	_	24	xcomp	_	_
27	that	that	IN	IN	_	31	mark	_	_
28	HLA	hla	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	31	nsubj	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	necessary	necessary	JJ	JJ	_	26	ccomp	_	_
32	but	but	CC	CC	_	31	cc	_	_
33	not	not	RB	RB	_	34	neg	_	_
34	sufficient	sufficient	JJ	JJ	_	31	conj	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	obtain	obtain	VB	VB	_	31	xcomp	_	_
37	an	a	DT	DT	_	40	det	_	_
38	in	in	FW	FW	_	40	amod	_	_
39	vitro	vitro	FW	FW	_	38	dep	_	_
40	response	response	NN	NN	_	36	dobj	_	_
41	.	.	.	.	_	1	punct	_	_

1	Further	further	RB	RB	_	2	advmod	_	_
2	optimization	optimization	NN	NN	_	26	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	culture	culture	NN	NN	_	5	compound	_	_
5	conditions	condition	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	type	type	NN	NN	_	5	appos	_	_
8	of	of	IN	IN	_	11	case	_	_
9	Antigen	antigen	NN	NN	_	11	compound	_	_
10	Presenting	presenting	NN	NN	_	11	compound	_	_
11	Cells	cell	NNS	NNS	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	APC	apc	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	peptides	peptide	NNS	NNS	_	11	appos	_	_
17	,	,	,	,	_	5	punct	_	_
18	use	use	NN	NN	_	5	appos	_	_
19	of	of	IN	IN	_	20	case	_	_
20	stabilizers	stabilizer	NNS	NNS	_	18	nmod	_	_
21	like	like	IN	IN	_	23	case	_	_
22	beta	beta	NN	NN	_	23	compound	_	_
23	2-m	2-m	NN	NN	_	20	nmod	_	_
24	are	be	VBP	VBP	_	26	auxpass	_	_
25	still	still	RB	RB	_	26	advmod	_	_
26	needed	need	VBN	VBN	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Control	control	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	I	i	NN	NN	_	12	compound	_	_
9	kappa	kappa	NN	NN	_	12	compound	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	beta	beta	NN	NN	_	12	compound	_	_
12	inhibitor	inhibitor	NN	NN	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	3	dep	_	_
6	is	be	VBZ	VBZ	_	7	aux	_	_
7	maintained	maintained	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	inactive	inactive	JJ	JJ	_	12	amod	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	10	dep	_	_
12	state	state	NN	NN	_	7	nmod	_	_
13	by	by	IN	IN	_	17	case	_	_
14	I	i	NN	NN	_	17	compound	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	inhibitors	inhibitor	NNS	NNS	_	7	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	mammalian	mammalian	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	I	i	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	17	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	I	i	NN	NN	_	14	compound	_	_
11	kappa	kappa	NN	NN	_	14	compound	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	beta	beta	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	8	conj	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	purified	purify	VBN	VBN	_	0	root	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	shown	show	VBN	VBN	_	17	conj	_	_
20	to	to	TO	TO	_	23	mark	_	_
21	be	be	VB	VB	_	23	cop	_	_
22	the	the	DT	DT	_	23	det	_	_
23	inhibitors	inhibitor	NNS	NNS	_	19	xcomp	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	nmod	_	_
27	through	through	IN	IN	_	29	case	_	_
28	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
29	association	association	NN	NN	_	23	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	dep	_	_
32	p65	p65	NN	NN	_	29	nmod	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	c-Rel	c-rel	NN	NN	_	32	conj	_	_
35	subunits	subunit	NNS	NNS	_	32	dep	_	_
36	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	isolated	isolate	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	11	det	_	_
8	third	third	JJ	JJ	_	11	amod	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	6	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	I	i	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	epsilon	epsilon	NN	NN	_	11	appos	_	_
17	(	(	-LRB-	-LRB-	_	16	punct	_	_
18	1	1	CD	CD	_	16	nummod	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	.	.	.	.	_	6	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	treatment	treatment	NN	NN	_	21	nmod	_	_
3	with	with	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	large	large	JJ	JJ	_	6	amod	_	_
6	variety	variety	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	inducers	inducer	NNS	NNS	_	6	nmod	_	_
9	,	,	,	,	_	21	punct	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	21	nsubjpass	_	_
14	,	,	,	,	_	13	punct	_	_
15	I	i	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	beta	beta	NN	NN	_	13	appos	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	proteolytically	proteolytically	RB	RB	_	21	advmod	_	_
21	degraded	degrade	VBN	VBN	_	0	root	_	_
22	,	,	,	,	_	21	punct	_	_
23	resulting	result	VBG	VBG	_	21	advcl	_	_
24	in	in	IN	IN	_	27	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	translocation	translocation	NN	NN	_	23	nmod	_	_
28	into	into	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	nucleus	nucleus	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	21	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	in	in	IN	IN	_	9	case	_	_
6	E29.1	e29.1	NN	NN	_	9	compound	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	hybridoma	hybridoma	NN	NN	_	21	nmod	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	21	nsubjpass	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	I	i	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	beta	beta	NN	NN	_	13	conj	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	equally	equally	RB	RB	_	21	advmod	_	_
21	associated	associate	VBN	VBN	_	3	ccomp	_	_
22	with	with	IN	IN	_	23	case	_	_
23	p65	p65	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	I	i	NN	NN	_	29	compound	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	beta	beta	NN	NN	_	31	nsubjpass	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	degraded	degrade	VBN	VBN	_	21	conj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	response	response	NN	NN	_	31	nmod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	TNF	tnf	NN	NN	_	36	compound	_	_
36	alpha	alpha	NN	NN	_	33	nmod	_	_
37	in	in	IN	IN	_	38	case	_	_
38	contrast	contrast	NN	NN	_	31	nmod	_	_
39	to	to	TO	TO	_	44	mark	_	_
40	what	what	WP	WP	_	44	nsubjpass	_	_
41	has	have	VBZ	VBZ	_	44	aux	_	_
42	been	be	VBN	VBN	_	44	auxpass	_	_
43	originally	originally	RB	RB	_	44	advmod	_	_
44	published	publish	VBN	VBN	_	38	acl	_	_
45	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	19	mark	_	_
6	,	,	,	,	_	19	punct	_	_
7	unlike	unlike	IN	IN	_	11	case	_	_
8	I	i	NN	NN	_	11	compound	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	19	nmod	_	_
12	,	,	,	,	_	19	punct	_	_
13	I	i	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	beta	beta	NN	NN	_	19	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	19	auxpass	_	_
18	constitutively	constitutively	RB	RB	_	19	advmod	_	_
19	phosphorylated	phosphorylate	VBN	VBN	_	4	ccomp	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	resynthesized	resynthesize	VBN	VBN	_	19	conj	_	_
22	as	as	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	hypophosphorylated	hypophosphorylate	VBN	VBN	_	25	amod	_	_
25	form	form	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	absence	absence	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	slow	slow	JJ	JJ	_	5	amod	_	_
5	migrating	migrating	JJ	JJ	_	6	amod	_	_
6	forms	form	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	I	i	NN	NN	_	11	compound	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	beta	beta	NN	NN	_	6	nmod	_	_
12	following	follow	VBG	VBG	_	2	acl	_	_
13	stimulation	stimulation	NN	NN	_	12	dobj	_	_
14	suggests	suggest	VBZ	VBZ	_	0	root	_	_
15	that	that	IN	IN	_	21	mark	_	_
16	the	the	DT	DT	_	17	det	_	_
17	phosphorylation	phosphorylation	NN	NN	_	21	nsubj	_	_
18	does	do	VBZ	VBZ	_	21	aux	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	necessarily	necessarily	RB	RB	_	21	advmod	_	_
21	constitute	constitute	VB	VB	_	14	ccomp	_	_
22	the	the	DT	DT	_	24	det	_	_
23	signal-induced	signal-induced	JJ	JJ	_	24	amod	_	_
24	event	event	NN	NN	_	21	dobj	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	targets	target	VBZ	VBZ	_	24	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	molecule	molecule	NN	NN	_	26	dobj	_	_
29	for	for	IN	IN	_	30	case	_	_
30	proteolysis	proteolysis	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	tolerance	tolerance	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	three	three	CD	CD	_	8	nummod	_	_
7	3'	3'	JJ	JJ	_	8	amod	_	_
8	cytosins	cytosin	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	2	dep	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	DNA	dna	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	10	nmod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	detection	detection	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	upregulated	upregulate	VBN	VBN	_	23	amod	_	_
20	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
21	B	b	NN	NN	_	23	compound	_	_
22	p50	p50	NN	NN	_	23	compound	_	_
23	homodimers	homodimer	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	monocytes	monocyte	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	stimulated	stimulate	VBN	VBN	_	28	advcl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	LPS	lps	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	repeatedly	repeatedly	RB	RB	_	4	advmod	_	_
11	then	then	RB	RB	_	28	advmod	_	_
12	the	the	DT	DT	_	15	det	_	_
13	initially	initially	RB	RB	_	14	advmod	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	28	nsubj	_	_
16	of	of	IN	IN	_	24	case	_	_
17	the	the	DT	DT	_	24	det	_	_
18	TNF	tnf	NN	NN	_	24	compound	_	_
19	(	(	-LRB-	-LRB-	_	24	punct	_	_
20	tumor	tumor	NN	NN	_	24	compound	_	_
21	necrosis	necrosis	NN	NN	_	24	compound	_	_
22	factor	factor	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	gene	gene	NN	NN	_	15	nmod	_	_
25	is	be	VBZ	VBZ	_	28	cop	_	_
26	only	only	RB	RB	_	28	advmod	_	_
27	very	very	RB	RB	_	28	advmod	_	_
28	low	low	JJ	JJ	_	0	root	_	_
29	,	,	,	,	_	28	punct	_	_
30	i.e.	i.e.	FW	FW	_	28	advcl	_	_
31	the	the	DT	DT	_	32	det	_	_
32	cells	cell	NNS	NNS	_	34	nsubj	_	_
33	are	be	VBP	VBP	_	34	cop	_	_
34	tolerant	tolerant	JJ	JJ	_	28	parataxis	_	_
35	to	to	TO	TO	_	36	case	_	_
36	LPS	lps	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	28	punct	_	_

1	Tolerant	tolerant	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	still	still	RB	RB	_	4	advmod	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CD14	cd14	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	4	dobj	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	they	they	PRP	PRP	_	13	nsubjpass	_	_
10	can	can	MD	MD	_	13	aux	_	_
11	still	still	RB	RB	_	13	advmod	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	activated	activate	VBN	VBN	_	4	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	mobilize	mobilize	VB	VB	_	13	xcomp	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	15	dobj	_	_
18	into	into	IN	IN	_	19	case	_	_
19	nucleus	nucleus	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Analysis	analysis	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	1	nmod	_	_
6	employing	employ	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	-605	-605	CD	CD	_	9	nummod	_	_
9	motif	motif	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	TNF	tnf	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	GGGGCTGTCCC	ggggctgtccc	NN	NN	_	9	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	revealed	reveal	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	33	mark	_	_
20	in	in	IN	IN	_	22	case	_	_
21	tolerant	tolerant	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	33	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	monocytic	monocytic	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	line	line	NN	NN	_	22	nmod	_	_
29	Mono	mono	NN	NN	_	30	compound	_	_
30	Mac	mac	NN	NN	_	28	dep	_	_
31	6	6	CD	CD	_	30	nummod	_	_
32	there	there	EX	EX	_	33	expl	_	_
33	is	be	VBZ	VBZ	_	18	ccomp	_	_
34	a	a	DT	DT	_	35	det	_	_
35	predominance	predominance	NN	NN	_	33	nsubj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	p50p50	p50p50	NN	NN	_	35	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	mutant	mutant	JJ	JJ	_	7	amod	_	_
7	motif	motif	NN	NN	_	17	nsubj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	exchanges	exchange	VBZ	VBZ	_	7	acl:relcl	_	_
10	the	the	DT	DT	_	13	det	_	_
11	terminal	terminal	JJ	JJ	_	13	amod	_	_
12	3'	3'	JJ	JJ	_	13	amod	_	_
13	C	c	NN	NN	_	9	dobj	_	_
14	for	for	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	G	g	NN	NN	_	9	nmod	_	_
17	fails	fail	VBZ	VBZ	_	3	ccomp	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	bind	bind	VB	VB	_	17	xcomp	_	_
20	the	the	DT	DT	_	22	det	_	_
21	p50	p50	NN	NN	_	22	compound	_	_
22	homodimer	homodimer	NN	NN	_	19	dobj	_	_
23	that	that	WDT	WDT	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	upregulated	upregulate	VBN	VBN	_	22	acl:relcl	_	_
26	in	in	IN	IN	_	34	case	_	_
27	LPS	lps	NN	NN	_	29	nmod:npmod	_	_
28	toler	toler	NN	NN	_	29	nmod:npmod	_	_
29	ant	ant	JJ	JJ	_	34	amod	_	_
30	human	human	JJ	JJ	_	34	amod	_	_
31	Mono	mono	NN	NN	_	34	compound	_	_
32	Mac	mac	NN	NN	_	34	compound	_	_
33	6	6	CD	CD	_	34	nummod	_	_
34	cells	cell	NNS	NNS	_	25	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	same	same	JJ	JJ	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	true	true	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	4	nmod	_	_
8	taken	take	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	murine	murine	JJ	JJ	_	15	amod	_	_
12	P388D1	p388d1	NN	NN	_	15	compound	_	_
13	macrophage	macrophage	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	8	nmod	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	tested	test	VBN	VBN	_	4	advcl	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	-516	-516	CD	CD	_	21	nummod	_	_
21	motif	motif	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	murine	murine	JJ	JJ	_	26	amod	_	_
25	TNF	tnf	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	21	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	GGGGGCTTTCCC	gggggctttccc	NN	NN	_	21	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	6	advmod	_	_
2	the	the	DT	DT	_	5	det	_	_
3	wild	wild	JJ	JJ	_	5	amod	_	_
4	type	type	NN	NN	_	5	compound	_	_
5	motif	motif	NN	NN	_	6	nsubj	_	_
6	gives	give	VBZ	VBZ	_	0	root	_	_
7	efficient	efficient	JJ	JJ	_	8	amod	_	_
8	binding	binding	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	p50p50	p50p50	NN	NN	_	8	nmod	_	_
11	that	that	WDT	WDT	_	14	nsubjpass	_	_
12	again	again	RB	RB	_	14	advmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	upregulated	upregulate	VBN	VBN	_	10	acl:relcl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	tolerant	tolerant	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	whereas	whereas	IN	IN	_	25	mark	_	_
19	a	a	DT	DT	_	20	det	_	_
20	mutant	mutant	NN	NN	_	25	nsubj	_	_
21	with	with	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	3'	3'	JJ	JJ	_	24	amod	_	_
24	G	g	NN	NN	_	20	nmod	_	_
25	shows	show	VBZ	VBZ	_	6	advcl	_	_
26	hardly	hardly	RB	RB	_	27	advmod	_	_
27	any	any	DT	DT	_	28	amod	_	_
28	binding	binding	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	p50p50	p50p50	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Conversely	conversely	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	9	det	_	_
4	murine	murine	JJ	JJ	_	9	amod	_	_
5	kappa	kappa	NN	NN	_	9	compound	_	_
6	light	light	JJ	JJ	_	9	amod	_	_
7	chain	chain	NN	NN	_	9	compound	_	_
8	enhancer	enhancer	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	16	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GGGGACTTTCCG	ggggactttccg	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	does	do	VBZ	VBZ	_	16	aux	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	efficiently	efficiently	RB	RB	_	16	advmod	_	_
16	bind	bind	VB	VB	_	0	root	_	_
17	the	the	DT	DT	_	19	det	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	p50p50	p50p50	NN	NN	_	16	dobj	_	_
20	from	from	IN	IN	_	24	case	_	_
21	tolerant	tolerant	JJ	JJ	_	24	amod	_	_
22	murine	murine	JJ	JJ	_	24	amod	_	_
23	P388	p388	NN	NN	_	24	compound	_	_
24	macrophages	macrophage	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Binding	binding	NN	NN	_	7	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	7	auxpass	_	_
3	,	,	,	,	_	7	punct	_	_
4	however	however	RB	RB	_	7	advmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	readily	readily	RB	RB	_	7	advmod	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	when	when	WRB	WRB	_	13	advmod	_	_
9	the	the	DT	DT	_	11	det	_	_
10	3'	3'	JJ	JJ	_	11	amod	_	_
11	G	g	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	replaced	replace	VBN	VBN	_	7	advcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	C	c	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	detection	detection	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	upregulated	upregulate	VBN	VBN	_	10	amod	_	_
9	p50	p50	NN	NN	_	10	compound	_	_
10	homodimers	homodimer	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	LPS	lps	NN	NN	_	10	nmod	_	_
13	tolerant	tolerant	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	12	dep	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	dependent	dependent	JJ	JJ	_	3	ccomp	_	_
17	on	on	IN	IN	_	19	case	_	_
18	subtle	subtle	JJ	JJ	_	19	amod	_	_
19	differences	difference	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	sequence	sequence	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	DNA	dna	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	motif	motif	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	winged-helix	winged-helix	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	7	nsubjpass	_	_
5	Trident	trident	NN	NN	_	4	dep	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	actively	actively	RB	RB	_	11	advmod	_	_
10	dividing	divide	VBG	VBG	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	winged-helix	winged-helix	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	Trident	trident	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	described	describe	VBD	VBD	_	3	conj	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	expression	expression	NN	NN	_	13	compound	_	_
13	pattern	pattern	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	synchronized	synchronize	VBN	VBN	_	16	amod	_	_
16	fibroblasts	fibroblast	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	studied	study	VBN	VBN	_	0	root	_	_
5	Trident	trident	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	differentiating	differentiate	VBG	VBG	_	12	amod	_	_
12	thymocytes	thymocyte	NNS	NNS	_	9	appos	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	in	in	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	9	conj	_	_
16	derived	derive	VBN	VBN	_	15	acl	_	_
17	from	from	IN	IN	_	19	case	_	_
18	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
19	blood	blood	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	During	during	IN	IN	_	4	case	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	differentiation	differentiation	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	expression	expression	NN	NN	_	7	nsubj	_	_
7	peaked	peak	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	actively	actively	RB	RB	_	15	advmod	_	_
11	dividing	divide	VBG	VBG	_	15	amod	_	_
12	immature	immature	JJ	JJ	_	15	amod	_	_
13	single	single	JJ	JJ	_	15	amod	_	_
14	positive	positive	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	peripheral	peripheral	JJ	JJ	_	4	amod	_	_
3	blood	blood	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	expression	expression	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Trident	trident	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	absent	absent	JJ	JJ	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	but	but	CC	CC	_	11	cc	_	_
14	could	could	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	11	conj	_	_
17	upon	upon	IN	IN	_	18	case	_	_
18	stimulation	stimulation	NN	NN	_	16	nmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	mitogens	mitogen	NNS	NNS	_	18	nmod	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vitro	vitro	FW	FW	_	18	advmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	function	function	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	Trident	trident	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	dividing	divide	VBG	VBG	_	10	amod	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Temporal	temporal	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	IgH	igh	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	developing	develop	VBG	VBG	_	10	amod	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	by	by	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	3'	3'	JJ	JJ	_	16	amod	_	_
14	locus	locus	NN	NN	_	16	compound	_	_
15	control	control	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	2	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	suggested	suggest	VBN	VBN	_	3	amod	_	_
3	roles	role	NNS	NNS	_	20	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	downstream	downstream	JJ	JJ	_	8	amod	_	_
7	3'	3'	JJ	JJ	_	8	amod	_	_
8	regions	region	NNS	NNS	_	3	nmod	_	_
9	acting	act	VBG	VBG	_	8	acl	_	_
10	as	as	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	Locus	locus	NN	NN	_	14	compound	_	_
13	Control	control	NN	NN	_	14	compound	_	_
14	Region	region	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	LCR	lcr	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	3	punct	_	_
19	have	have	VBP	VBP	_	20	aux	_	_
20	allowed	allow	VBN	VBN	_	0	root	_	_
21	comparisons	comparison	NNS	NNS	_	20	dobj	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	made	make	VBN	VBN	_	20	xcomp	_	_
25	between	between	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	regulation	regulation	NN	NN	_	20	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	IgH	igh	JJ	JJ	_	31	amod	_	_
31	locus	locus	NN	NN	_	27	nmod	_	_
32	with	with	IN	IN	_	35	case	_	_
33	other	other	JJ	JJ	_	35	amod	_	_
34	model	model	NN	NN	_	35	compound	_	_
35	systems	system	NNS	NNS	_	20	nmod	_	_
36	whose	whose	WP$	WP$	_	38	nmod:poss	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	40	nsubjpass	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	governed	govern	VBN	VBN	_	35	acl:relcl	_	_
41	by	by	IN	IN	_	43	case	_	_
42	LCR	lcr	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	20	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	summarize	summarize	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	importance	importance	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IgH	igh	JJ	JJ	_	9	amod	_	_
9	3'LCR	3'lcr	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
12	putative	putative	JJ	JJ	_	14	amod	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	role	role	NN	NN	_	5	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	IgH	igh	JJ	JJ	_	17	amod	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	compare	compare	VBP	VBP	_	3	conj	_	_
21	it	it	PRP	PRP	_	20	dobj	_	_
22	with	with	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	5'LCR	5'lcr	NN	NN	_	26	compound	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	region	region	NN	NN	_	20	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	beta-globin	beta-globin	NN	NN	_	31	compound	_	_
31	locus	locus	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	transcription	transcription	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	1	nmod	_	_
6	after	after	IN	IN	_	10	case	_	_
7	influenza	influenza	NN	NN	_	10	compound	_	_
8	A	a	NN	NN	_	10	compound	_	_
9	virus	virus	NN	NN	_	10	compound	_	_
10	infection	infection	NN	NN	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Infection	infection	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	influenza	influenza	NN	NN	_	8	compound	_	_
7	A	a	NN	NN	_	8	compound	_	_
8	virus	virus	NN	NN	_	1	nmod	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	broad	broad	JJ	JJ	_	12	amod	_	_
12	range	range	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	proinflammatory	proinflammatory	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	cell	cell	NN	NN	_	15	conj	_	_
19	attracting	attracting	NN	NN	_	18	dep	_	_
20	chemokines	chemokine	NNS	NNS	_	19	dobj	_	_
21	before	before	IN	IN	_	25	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	infected	infected	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	25	nsubj	_	_
25	undergo	undergo	VBP	VBP	_	9	advcl	_	_
26	apoptosis	apoptosis	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	underlying	underlie	VBG	VBG	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	18	nsubjpass	_	_
4	by	by	IN	IN	_	5	case	_	_
5	which	which	WDT	WDT	_	11	nmod	_	_
6	the	the	DT	DT	_	8	det	_	_
7	corresponding	corresponding	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	11	nsubjpass	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	transcriptionally	transcriptionally	RB	RB	_	11	advmod	_	_
11	initiated	initiate	VBN	VBN	_	3	acl:relcl	_	_
12	after	after	IN	IN	_	14	case	_	_
13	virus	virus	NN	NN	_	14	compound	_	_
14	infection	infection	NN	NN	_	11	nmod	_	_
15	are	be	VBP	VBP	_	18	auxpass	_	_
16	still	still	RB	RB	_	18	advmod	_	_
17	poorly	poorly	RB	RB	_	18	advmod	_	_
18	understood	understand	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	seems	seem	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	play	play	VB	VB	_	5	xcomp	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	many	many	JJ	JJ	_	18	amod	_	_
16	proinflammatory	proinflammatory	JJ	JJ	_	18	amod	_	_
17	cytokine	cytokine	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	but	but	CC	CC	_	5	cc	_	_
21	can	can	MD	MD	_	26	aux	_	_
22	not	not	RB	RB	_	26	neg	_	_
23	be	be	VB	VB	_	26	cop	_	_
24	the	the	DT	DT	_	26	det	_	_
25	only	only	JJ	JJ	_	26	amod	_	_
26	mechanism	mechanism	NN	NN	_	5	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	since	since	IN	IN	_	32	mark	_	_
29	several	several	JJ	JJ	_	31	amod	_	_
30	cytokine	cytokine	NN	NN	_	31	compound	_	_
31	genes	gene	NNS	NNS	_	32	nsubj	_	_
32	lack	lack	VBP	VBP	_	26	advcl	_	_
33	respective	respective	JJ	JJ	_	35	amod	_	_
34	binding	bind	VBG	VBG	_	35	amod	_	_
35	sites	site	NNS	NNS	_	32	dobj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	their	they	PRP$	PRP$	_	39	nmod:poss	_	_
38	promoter	promoter	NN	NN	_	39	compound	_	_
39	regions	region	NNS	NNS	_	32	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	additionally	additionally	RB	RB	_	5	advmod	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	possible	possible	JJ	JJ	_	11	amod	_	_
11	importance	importance	NN	NN	_	8	nmod	_	_
12	such	such	JJ	JJ	_	14	case	_	_
13	as	as	IN	IN	_	12	mwe	_	_
14	CREB	creb	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	CTF	ctf	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	OTF-1	otf-1	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	OTF-2	otf-2	NN	NN	_	14	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	explore	explore	VB	VB	_	0	root	_	_
3	long-term	long-term	JJ	JJ	_	5	amod	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	investigated	investigate	VBD	VBD	_	2	parataxis	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	on	on	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	gene	gene	NN	NN	_	18	compound	_	_
17	expression	expression	NN	NN	_	18	compound	_	_
18	level	level	NN	NN	_	10	nmod	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	important	important	JJ	JJ	_	10	acl:relcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	substitute	substitute	VB	VB	_	22	xcomp	_	_
25	for	for	IN	IN	_	29	case	_	_
26	metabolized	metabolize	VBN	VBN	_	29	amod	_	_
27	transcription	transcription	NN	NN	_	29	compound	_	_
28	factor	factor	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	24	nmod	_	_
30	after	after	IN	IN	_	32	case	_	_
31	their	they	PRP$	PRP$	_	32	nmod:poss	_	_
32	activation	activation	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	cell-type-specific	cell-type-specific	JJ	JJ	_	6	amod	_	_
5	differential	differential	JJ	JJ	_	4	dep	_	_
6	response	response	NN	NN	_	2	dobj	_	_
7	:	:	:	:	_	2	punct	_	_
8	CREB	creb	NN	NN	_	22	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	CTF	ctf	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	OTF-1	otf-1	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	OFT-2	oft-2	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	8	conj	_	_
19	genes	gene	NNS	NNS	_	8	dep	_	_
20	were	be	VBD	VBD	_	22	auxpass	_	_
21	strongly	strongly	RB	RB	_	22	advmod	_	_
22	induced	induce	VBN	VBN	_	2	parataxis	_	_
23	1	1	CD	CD	_	25	compound	_	_
24	to	to	TO	TO	_	25	dep	_	_
25	4	4	CD	CD	_	26	nummod	_	_
26	hours	hour	NNS	NNS	_	22	nmod	_	_
27	after	after	IN	IN	_	26	case	_	_
28	influenza	influenza	NN	NN	_	31	compound	_	_
29	A	a	NN	NN	_	31	compound	_	_
30	virus	virus	NN	NN	_	31	compound	_	_
31	infection	infection	NN	NN	_	26	dep	_	_
32	in	in	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	monocytic	monocytic	JJ	JJ	_	36	amod	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	line	line	NN	NN	_	22	nmod	_	_
37	Mono	mono	NN	NN	_	38	compound	_	_
38	Mac	mac	NN	NN	_	36	dep	_	_
39	6	6	CD	CD	_	38	nummod	_	_
40	,	,	,	,	_	22	punct	_	_
41	while	while	IN	IN	_	51	mark	_	_
42	in	in	IN	IN	_	46	case	_	_
43	freshly	freshly	RB	RB	_	44	advmod	_	_
44	prepared	prepare	VBN	VBN	_	46	amod	_	_
45	human	human	JJ	JJ	_	46	amod	_	_
46	monocytes	monocyte	NNS	NNS	_	51	nmod	_	_
47	no	no	DT	DT	_	49	neg	_	_
48	significant	significant	JJ	JJ	_	49	amod	_	_
49	changes	change	NNS	NNS	_	51	nsubjpass	_	_
50	were	be	VBD	VBD	_	51	auxpass	_	_
51	detected	detect	VBN	VBN	_	22	advcl	_	_
52	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	infected	infected	JJ	JJ	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	die	die	VBP	VBP	_	3	acl:relcl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	21	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	21	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	CREB	creb	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	CTF	ctf	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	OTF-2	otf-2	NN	NN	_	13	conj	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	rather	rather	RB	RB	_	21	advmod	_	_
21	suppressed	suppress	VBN	VBN	_	0	root	_	_
22	8	8	CD	CD	_	23	nummod	_	_
23	hours	hour	NNS	NNS	_	21	nmod	_	_
24	after	after	IN	IN	_	23	case	_	_
25	infection	infection	NN	NN	_	23	dep	_	_
26	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	long-term	long-term	JJ	JJ	_	6	amod	_	_
6	regulation	regulation	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	non-proliferating	non-proliferating	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	seems	seem	VBZ	VBZ	_	0	root	_	_
16	to	to	TO	TO	_	20	mark	_	_
17	be	be	VB	VB	_	20	cop	_	_
18	of	of	IN	IN	_	20	case	_	_
19	minor	minor	JJ	JJ	_	20	amod	_	_
20	importance	importance	NN	NN	_	15	xcomp	_	_
21	after	after	IN	IN	_	23	case	_	_
22	influenza	influenza	NN	NN	_	23	compound	_	_
23	infection	infection	NN	NN	_	20	nmod	_	_
24	since	since	IN	IN	_	36	mark	_	_
25	in	in	IN	IN	_	27	case	_	_
26	apoptosisprone	apoptosisprone	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	36	nmod	_	_
28	an	a	DT	DT	_	30	det	_	_
29	immediate	immediate	JJ	JJ	_	30	amod	_	_
30	availability	availability	NN	NN	_	36	nsubjpass	_	_
31	of	of	IN	IN	_	34	case	_	_
32	transcription	transcription	NN	NN	_	34	compound	_	_
33	factor	factor	NN	NN	_	34	compound	_	_
34	proteins	protein	NNS	NNS	_	30	nmod	_	_
35	is	be	VBZ	VBZ	_	36	auxpass	_	_
36	required	require	VBN	VBN	_	15	advcl	_	_
37	.	.	.	.	_	15	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	interleukin-12	interleukin-12	NN	NN	_	1	nmod	_	_
4	p40	p40	NN	NN	_	5	compound	_	_
5	transcript	transcript	NN	NN	_	3	dep	_	_
6	by	by	IN	IN	_	8	case	_	_
7	CD40	cd40	NN	NN	_	8	compound	_	_
8	ligation	ligation	NN	NN	_	1	nmod	_	_
9	via	via	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factor-kappaB	factor-kappab	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Interleukin-12	interleukin-12	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	produced	produce	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	response	response	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	infection	infection	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	bacteria	bacterium	NNS	NNS	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	parasites	parasite	NNS	NNS	_	9	conj	_	_
12	or	or	CC	CC	_	7	cc	_	_
13	to	to	TO	TO	_	15	case	_	_
14	bacterial	bacterial	JJ	JJ	_	15	amod	_	_
15	constituents	constituent	NNS	NNS	_	7	conj	_	_
16	such	such	JJ	JJ	_	18	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	LPS	lps	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	dendritic	dendritic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	,	,	,	,	_	3	punct	_	_
25	and	and	CC	CC	_	3	cc	_	_
26	also	also	RB	RB	_	27	advmod	_	_
27	generated	generate	VBN	VBN	_	3	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	interaction	interaction	NN	NN	_	27	nmod	_	_
31	between	between	IN	IN	_	34	case	_	_
32	activated	activate	VBN	VBN	_	34	amod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	antigen-presenting	antigen-presenting	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	34	conj	_	_
38	via	via	IN	IN	_	40	case	_	_
39	CD40-CD40	cd40-cd40	NN	NN	_	40	compound	_	_
40	ligand	ligand	NN	NN	_	34	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	CD40L	cd40l	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	3	punct	_	_

1	So	so	RB	RB	_	2	advmod	_	_
2	far	far	RB	RB	_	10	advmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	analyses	analysis	NNS	NNS	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p40	p40	NN	NN	_	5	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	carried	carry	VBN	VBN	_	0	root	_	_
11	out	out	RP	RP	_	10	compound:prt	_	_
12	only	only	RB	RB	_	13	advmod	_	_
13	using	use	VBG	VBG	_	10	xcomp	_	_
14	bacterial	bacterial	JJ	JJ	_	15	amod	_	_
15	constituents	constituent	NNS	NNS	_	13	dobj	_	_
16	such	such	JJ	JJ	_	18	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	LPS	lps	NN	NN	_	15	nmod	_	_
19	as	as	IN	IN	_	20	case	_	_
20	stimuli	stimulus	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	characterized	characterize	VBN	VBN	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	induction	induction	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	p40	p40	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	CD40	cd40	NN	NN	_	16	compound	_	_
16	ligation	ligation	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	23	case	_	_
18	a	a	DT	DT	_	23	det	_	_
19	human	human	JJ	JJ	_	23	amod	_	_
20	B	b	NN	NN	_	23	compound	_	_
21	lymphoblastoid	lymphoblastoid	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	line	line	NN	NN	_	16	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	Daudi	daudi	NN	NN	_	23	appos	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	a	a	DT	DT	_	34	det	_	_
29	human	human	JJ	JJ	_	34	amod	_	_
30	acute	acute	JJ	JJ	_	34	amod	_	_
31	monocytic	monocytic	JJ	JJ	_	34	amod	_	_
32	leukemia	leukemia	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	line	line	NN	NN	_	23	conj	_	_
35	,	,	,	,	_	34	punct	_	_
36	THP-1	thp-1	NN	NN	_	34	appos	_	_
37	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	21	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	stimulated	stimulate	VBN	VBN	_	2	acl	_	_
5	by	by	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	agonistic	agonistic	JJ	JJ	_	9	amod	_	_
8	monoclonal	monoclonal	JJ	JJ	_	9	amod	_	_
9	antibody	antibody	NN	NN	_	4	nmod	_	_
10	against	against	IN	IN	_	11	case	_	_
11	CD40	cd40	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	9	cc	_	_
13	by	by	IN	IN	_	14	case	_	_
14	transfection	transfection	NN	NN	_	9	conj	_	_
15	with	with	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	CD40L	cd40l	NN	NN	_	19	compound	_	_
18	expression	expression	NN	NN	_	19	compound	_	_
19	vector	vector	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	2	punct	_	_
21	secreted	secrete	VBD	VBD	_	0	root	_	_
22	p40	p40	NN	NN	_	21	dobj	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	showed	show	VBD	VBD	_	21	conj	_	_
25	enhanced	enhance	VBN	VBN	_	28	amod	_	_
26	p40	p40	NN	NN	_	27	compound	_	_
27	mRNA	mrna	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	dobj	_	_
29	.	.	.	.	_	21	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	p40	p40	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	region	region	NN	NN	_	2	nmod	_	_
8	identified	identify	VBD	VBD	_	0	root	_	_
9	two	two	CD	CD	_	18	nummod	_	_
10	potential	potential	JJ	JJ	_	18	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
12	factor	factor	NN	NN	_	18	compound	_	_
13	(	(	-LRB-	-LRB-	_	18	punct	_	_
14	NF	nf	NN	NN	_	18	compound	_	_
15	)	)	-RRB-	-RRB-	_	18	punct	_	_
16	-kappaB	-kappab	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	sites	site	NNS	NNS	_	8	dobj	_	_
19	conserved	conserve	VBN	VBN	_	18	acl	_	_
20	between	between	IN	IN	_	21	case	_	_
21	mouse	mouse	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	human	human	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	8	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	30	mark	_	_
7	the	the	DT	DT	_	11	det	_	_
8	potential	potential	JJ	JJ	_	11	amod	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	sequence	sequence	NN	NN	_	30	nsubj	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	located	located	JJ	JJ	_	11	acl:relcl	_	_
15	around	around	IN	IN	_	17	case	_	_
16	120	120	CD	CD	_	17	nummod	_	_
17	bp	bp	NN	NN	_	14	nmod	_	_
18	upstream	upstream	RB	RB	_	17	advmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	transcription	transcription	NN	NN	_	23	compound	_	_
22	initiation	initiation	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	17	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	murine	murine	JJ	JJ	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	human	human	JJ	JJ	_	25	conj	_	_
28	p40	p40	NN	NN	_	29	compound	_	_
29	genes	gene	NNS	NNS	_	25	dep	_	_
30	formed	form	VBD	VBD	_	5	ccomp	_	_
31	an	a	DT	DT	_	33	det	_	_
32	NF-kappaB	nf-kappab	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	30	dobj	_	_
34	with	with	IN	IN	_	36	case	_	_
35	nuclear	nuclear	JJ	JJ	_	36	amod	_	_
36	extract	extract	NN	NN	_	33	nmod	_	_
37	from	from	IN	IN	_	39	case	_	_
38	Daudi	daudi	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	stimulated	stimulate	VBN	VBN	_	39	acl	_	_
41	by	by	IN	IN	_	43	case	_	_
42	CD40	cd40	NN	NN	_	43	compound	_	_
43	ligation	ligation	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	transfection	transfection	NN	NN	_	25	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Daudi	daudi	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	polymerized	polymerized	JJ	JJ	_	12	amod	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	3	nmod	_	_
13	ligated	ligate	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	23	case	_	_
15	a	a	DT	DT	_	23	det	_	_
16	thymidine	thymidine	NN	NN	_	23	compound	_	_
17	kinase/chloramphenicol	kinase/chloramphenicol	NN	NN	_	23	compound	_	_
18	acetyltransferase	acetyltransferase	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	CAT	cat	NN	NN	_	23	compound	_	_
21	)	)	-RRB-	-RRB-	_	23	punct	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	plasmid	plasmid	NN	NN	_	13	nmod	_	_
24	greatly	greatly	RB	RB	_	25	advmod	_	_
25	induced	induce	VBD	VBD	_	0	root	_	_
26	CAT	cat	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	25	dobj	_	_
28	,	,	,	,	_	25	punct	_	_
29	but	but	CC	CC	_	25	cc	_	_
30	transfection	transfection	NN	NN	_	38	nsubj	_	_
31	with	with	IN	IN	_	37	case	_	_
32	the	the	DT	DT	_	37	det	_	_
33	polymerized	polymerized	JJ	JJ	_	37	amod	_	_
34	mutated	mutate	VBN	VBN	_	37	amod	_	_
35	NF-kappaB	nf-kappab	NN	NN	_	37	compound	_	_
36	binding	binding	NN	NN	_	37	compound	_	_
37	sequence	sequence	NN	NN	_	30	nmod	_	_
38	did	do	VBD	VBD	_	25	conj	_	_
39	not	not	RB	RB	_	38	neg	_	_
40	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	28	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	28	nsubj	_	_
9	located	located	JJ	JJ	_	8	amod	_	_
10	around	around	IN	IN	_	12	case	_	_
11	120	120	CD	CD	_	12	nummod	_	_
12	bp	bp	NN	NN	_	9	nmod	_	_
13	upstream	upstream	RB	RB	_	12	advmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	initiation	initiation	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	12	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	murine	murine	JJ	JJ	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	human	human	JJ	JJ	_	20	conj	_	_
23	p40	p40	NN	NN	_	25	compound	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	regions	region	NNS	NNS	_	20	dep	_	_
26	could	could	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	cop	_	_
28	important	important	JJ	JJ	_	3	ccomp	_	_
29	for	for	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	p40	p40	NN	NN	_	32	compound	_	_
32	induction	induction	NN	NN	_	28	nmod	_	_
33	by	by	IN	IN	_	35	case	_	_
34	CD40	cd40	NN	NN	_	35	compound	_	_
35	ligation	ligation	NN	NN	_	32	nmod	_	_
36	via	via	IN	IN	_	37	case	_	_
37	activation	activation	NN	NN	_	35	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	NF-kappaB	nf-kappab	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	10	case	_	_
3	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
4	factor	factor	NN	NN	_	10	compound	_	_
5	kappa	kappa	NN	NN	_	10	compound	_	_
6	B	b	NN	NN	_	10	compound	_	_
7	subunit	subunit	NN	NN	_	10	compound	_	_
8	p65	p65	NN	NN	_	10	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	accumulation	accumulation	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	15	amod	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	treated	treat	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	sodium	sodium	NN	NN	_	19	compound	_	_
19	salicylate	salicylate	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	14	nsubj	_	_
2	is	be	VBZ	VBZ	_	14	cop	_	_
3	one	one	CD	CD	_	14	dep	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	most	most	RBS	RBS	_	7	advmod	_	_
7	potent	potent	JJ	JJ	_	9	amod	_	_
8	trigger	trigger	NN	NN	_	9	compound	_	_
9	substances	substance	NNS	NNS	_	3	nmod	_	_
10	for	for	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	macrophages	macrophage	NNS	NNS	_	11	conj	_	_
14	causing	cause	VBG	VBG	_	0	root	_	_
15	secretion	secretion	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	inflammatory	inflammatory	JJ	JJ	_	18	amod	_	_
18	mediators	mediator	NNS	NNS	_	15	nmod	_	_
19	such	such	JJ	JJ	_	23	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	tumor	tumor	NN	NN	_	23	compound	_	_
22	necrosis	necrosis	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	interleukin-1	interleukin-1	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	nature	nature	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	9	case	_	_
9	regulation	regulation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	these	these	DT	DT	_	13	det	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	still	still	RB	RB	_	16	advmod	_	_
16	unknown	unknown	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	15	amod	_	_
2	factor	factor	NN	NN	_	15	compound	_	_
3	kappa	kappa	NN	NN	_	15	compound	_	_
4	B	b	NN	NN	_	15	compound	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	15	dep	_	_
8	;	;	:	:	_	7	punct	_	_
9	heterodimer	heterodimer	NN	NN	_	7	dep	_	_
10	of	of	IN	IN	_	11	case	_	_
11	p50	p50	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	p65	p65	NN	NN	_	11	conj	_	_
14	)	)	-RRB-	-RRB-	_	7	punct	_	_
15	proteins	protein	NNS	NNS	_	18	nsubjpass	_	_
16	have	have	VBP	VBP	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	suggested	suggest	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	play	play	VB	VB	_	18	xcomp	_	_
21	an	a	DT	DT	_	23	det	_	_
22	important	important	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	20	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	inflammatory	inflammatory	JJ	JJ	_	29	amod	_	_
29	mediators	mediator	NNS	NNS	_	26	nmod	_	_
30	when	when	WRB	WRB	_	33	advmod	_	_
31	monocytes	monocyte	NNS	NNS	_	33	nsubjpass	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	stimulated	stimulate	VBN	VBN	_	20	dep	_	_
34	with	with	IN	IN	_	35	case	_	_
35	lipopolysaccharide	lipopolysaccharide	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	18	punct	_	_

1	Nonsteroidal	nonsteroidal	JJ	JJ	_	3	amod	_	_
2	anti-inflammatory	anti-inflammatory	JJ	JJ	_	3	amod	_	_
3	drugs	drug	NNS	NNS	_	9	nsubjpass	_	_
4	such	such	JJ	JJ	_	6	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	salicylates	salicylate	NNS	NNS	_	3	nmod	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	treat	treat	VB	VB	_	9	xcomp	_	_
12	symptoms	symptom	NNS	NNS	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	inflammation	inflammation	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	a	a	DT	DT	_	19	det	_	_
18	new	new	JJ	JJ	_	19	amod	_	_
19	mechanism	mechanism	NN	NN	_	24	nsubjpass	_	_
20	of	of	IN	IN	_	22	case	_	_
21	drug	drug	NN	NN	_	22	compound	_	_
22	action	action	NN	NN	_	19	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	suggested	suggest	VBN	VBN	_	9	conj	_	_
25	recently	recently	RB	RB	_	24	advmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Salicylates	salicylate	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	4	xcomp	_	_
7	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	via	via	IN	IN	_	11	case	_	_
11	inhibition	inhibition	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	preventing	prevent	VBG	VBG	_	11	acl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	degradation	degradation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	inhibitor	inhibitor	NN	NN	_	19	nmod	_	_
24	``	``	``	``	_	27	punct	_	_
25	I	i	NN	NN	_	27	compound	_	_
26	kappa	kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	23	dep	_	_
28	,	,	,	,	_	17	punct	_	_
29	blocking	block	VBG	VBG	_	17	dep	_	_
30	the	the	DT	DT	_	31	det	_	_
31	translocation	translocation	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	31	nmod	_	_
35	into	into	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	nuclear	nuclear	JJ	JJ	_	38	amod	_	_
38	compartment	compartment	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	nature	nature	NN	NN	_	15	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	subunit	subunit	NN	NN	_	4	nmod	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	mechanism	mechanism	NN	NN	_	8	nmod	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	defined	define	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	34	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	salicylates	salicylate	NNS	NNS	_	8	nsubj	_	_
8	affect	affect	VBP	VBP	_	4	acl:relcl	_	_
9	cytokine	cytokine	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	34	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	amount	amount	NN	NN	_	34	nsubjpass	_	_
15	of	of	IN	IN	_	20	case	_	_
16	active	active	JJ	JJ	_	20	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	inactive	inactive	JJ	JJ	_	16	conj	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	14	punct	_	_
26	in	in	IN	IN	_	32	case	_	_
27	Porphyromonas	porphyromonas	NN	NN	_	32	compound	_	_
28	gingivalis	gingivalis	NN	NN	_	32	compound	_	_
29	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	32	amod	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	monocytic	monocytic	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	14	nmod	_	_
33	was	be	VBD	VBD	_	34	auxpass	_	_
34	assessed	assess	VBN	VBN	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	High	high	JJ	JJ	_	2	amod	_	_
2	doses	dose	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	sodium	sodium	NN	NN	_	5	compound	_	_
5	salicylate	salicylate	NN	NN	_	2	nmod	_	_
6	suppressed	suppress	VBD	VBD	_	0	root	_	_
7	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
8	B	b	NN	NN	_	11	compound	_	_
9	p65	p65	NN	NN	_	11	compound	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	accumulation	accumulation	NN	NN	_	6	dobj	_	_
12	,	,	,	,	_	6	punct	_	_
13	resulting	result	VBG	VBG	_	6	advcl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	suppression	suppression	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	total	total	JJ	JJ	_	19	amod	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	p50	p50	NN	NN	_	25	nsubj	_	_
22	on	on	IN	IN	_	24	case	_	_
23	tissue	tissue	NN	NN	_	24	compound	_	_
24	oligonucleotide	oligonucleotide	NN	NN	_	21	nmod	_	_
25	had	have	VBD	VBD	_	6	parataxis	_	_
26	no	no	DT	DT	_	27	neg	_	_
27	effects	effect	NNS	NNS	_	25	dobj	_	_
28	on	on	IN	IN	_	32	case	_	_
29	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	32	amod	_	_
30	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	p65	p65	NN	NN	_	7	compound	_	_
7	subunit	subunit	NN	NN	_	12	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	inhibited	inhibit	VBN	VBN	_	3	ccomp	_	_
13	by	by	IN	IN	_	15	case	_	_
14	salicylate	salicylate	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	highlight	highlight	VBP	VBP	_	12	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	role	role	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	salicylate	salicylate	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	control	control	NN	NN	_	17	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	inflammatory	inflammatory	JJ	JJ	_	30	amod	_	_
30	mediators	mediator	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	cord	cord	NN	NN	_	6	compound	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	healthy	healthy	JJ	JJ	_	9	amod	_	_
9	neonates	neonate	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	of	of	IN	IN	_	12	case	_	_
12	preterms	preterm	NNS	NNS	_	9	conj	_	_
13	suffering	suffer	VBG	VBG	_	12	acl	_	_
14	from	from	IN	IN	_	17	case	_	_
15	respiratory	respiratory	JJ	JJ	_	17	amod	_	_
16	distress	distress	NN	NN	_	17	compound	_	_
17	syndrome	syndrome	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	measured	measure	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	number	number	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	GR	gr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	14	case	_	_
12	cord	cord	NN	NN	_	14	compound	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	affinity	affinity	NN	NN	_	4	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	Kd	kd	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	in	in	IN	IN	_	24	case	_	_
23	15	15	CD	CD	_	24	nummod	_	_
24	term	term	NN	NN	_	4	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	in	in	IN	IN	_	29	case	_	_
27	20	20	CD	CD	_	29	nummod	_	_
28	preterm	preterm	JJ	JJ	_	29	amod	_	_
29	babies	baby	NNS	NNS	_	24	conj	_	_
30	.	.	.	.	_	2	punct	_	_

1	Thirteen	thirteen	CD	CD	_	2	nummod	_	_
2	preterms	preterm	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	latter	latter	JJ	JJ	_	6	amod	_	_
6	group	group	NN	NN	_	2	nmod	_	_
7	received	receive	VBD	VBD	_	0	root	_	_
8	prenatal	prenatal	JJ	JJ	_	10	amod	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	treatment	treatment	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	7	punct	_	_

1	Seven	seven	CD	CD	_	2	nummod	_	_
2	preterms	preterm	NNS	NNS	_	3	nsubj	_	_
3	developed	develop	VBD	VBD	_	0	root	_	_
4	neonatal	neonatal	JJ	JJ	_	7	amod	_	_
5	respiratory	respiratory	JJ	JJ	_	7	amod	_	_
6	distress	distress	NN	NN	_	7	compound	_	_
7	syndrome	syndrome	NN	NN	_	3	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NRDS	nrds	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GR	gr	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	Kd	kd	NN	NN	_	2	conj	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	dep	_	_
12	term	term	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	preterm	preterm	JJ	JJ	_	12	conj	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	with	with	IN	IN	_	19	nmod	_	_
17	and	and	CC	CC	_	19	cc	_	_
18	without	without	IN	IN	_	19	conj	_	_
19	NRDS	nrds	NN	NN	_	14	nmod	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	babies	baby	NNS	NNS	_	12	dep	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	maximum	maximum	NN	NN	_	4	compound	_	_
3	(3H)-thymidine	(3h)-thymidine	NN	NN	_	4	compound	_	_
4	incorporation	incorporation	NN	NN	_	20	nsubjpass	_	_
5	into	into	IN	IN	_	6	case	_	_
6	DNA	dna	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	cord	cord	NN	NN	_	10	compound	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	all	all	DT	DT	_	13	det	_	_
13	preterms	preterm	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	with	with	IN	IN	_	18	nmod	_	_
16	or	or	CC	CC	_	18	cc	_	_
17	without	without	IN	IN	_	18	conj	_	_
18	NRDS	nrds	NN	NN	_	13	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	suppressed	suppress	VBN	VBN	_	0	root	_	_
21	when	when	WRB	WRB	_	22	advmod	_	_
22	compared	compare	VBN	VBN	_	20	advcl	_	_
23	to	to	TO	TO	_	24	case	_	_
24	that	that	DT	DT	_	22	nmod	_	_
25	from	from	IN	IN	_	27	case	_	_
26	term	term	NN	NN	_	27	compound	_	_
27	babies	baby	NNS	NNS	_	24	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	adults	adult	NNS	NNS	_	27	conj	_	_
30	.	.	.	.	_	20	punct	_	_

1	This	this	DT	DT	_	5	nsubjpass	_	_
2	could	could	MD	MD	_	5	aux	_	_
3	partly	partly	RB	RB	_	5	advmod	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	explained	explain	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	antenatal	antenatal	JJ	JJ	_	10	amod	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	treatment	treatment	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Sensitivity	sensitivity	NN	NN	_	16	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	ID50	id50	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	dexamethasone	dexamethasone	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	the	the	DT	DT	_	16	det	_	_
16	same	same	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	all	all	DT	DT	_	19	det	_	_
19	groups	group	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	16	nmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	number	number	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	function	function	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	GR	gr	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	unable	unable	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	find	find	VB	VB	_	16	xcomp	_	_
19	a	a	DT	DT	_	20	det	_	_
20	relation	relation	NN	NN	_	18	dobj	_	_
21	between	between	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	functionality	functionality	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	GR	gr	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	the	the	DT	DT	_	29	det	_	_
29	development	development	NN	NN	_	23	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	NRDS	nrds	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	Oxidants	oxidant	NNS	NNS	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	conj	_	_
5	,	,	,	,	_	1	punct	_	_
6	and	and	CC	CC	_	1	cc	_	_
7	intestinal	intestinal	JJ	JJ	_	8	amod	_	_
8	inflammation	inflammation	NN	NN	_	1	conj	_	_
9	.	.	.	.	_	1	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	5	auxpass	_	_
3	now	now	RB	RB	_	5	advmod	_	_
4	well	well	RB	RB	_	5	advmod	_	_
5	appreciated	appreciate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	chronic	chronic	JJ	JJ	_	9	amod	_	_
8	gut	gut	NN	NN	_	9	compound	_	_
9	inflammation	inflammation	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	characterized	characterize	VBN	VBN	_	5	ccomp	_	_
12	by	by	IN	IN	_	14	case	_	_
13	enhanced	enhance	VBN	VBN	_	14	amod	_	_
14	production	production	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	reactive	reactive	JJ	JJ	_	17	amod	_	_
17	metabolites	metabolite	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	oxygen	oxygen	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	nitrogen	nitrogen	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Some	some	DT	DT	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	oxidants	oxidant	NNS	NNS	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	modulate	modulate	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	variety	variety	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	genes	gene	NNS	NNS	_	13	nmod	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	involved	involve	VBN	VBN	_	13	acl:relcl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	immune	immune	JJ	JJ	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	inflammatory	inflammatory	JJ	JJ	_	21	conj	_	_
24	responses	response	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	6	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	example	example	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	certain	certain	JJ	JJ	_	5	amod	_	_
5	oxidants	oxidant	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	known	know	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	15	det	_	_
11	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
12	transcription	transcription	NN	NN	_	15	compound	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	9	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	regulates	regulate	VBZ	VBZ	_	15	acl:relcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	variety	variety	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	different	different	JJ	JJ	_	27	amod	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	molecules	molecule	NNS	NNS	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	cytokines	cytokine	NNS	NNS	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	enzymes	enzyme	NNS	NNS	_	27	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	Oxidants	oxidant	NNS	NNS	_	4	nsubjpass	_	_
2	are	be	VBP	VBP	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	known	know	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	activate	activate	VB	VB	_	4	xcomp	_	_
7	another	another	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	activator	activator	NN	NN	_	12	compound	_	_
12	protein-1	protein-1	NN	NN	_	9	appos	_	_
13	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	composed	compose	VBN	VBN	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	products	product	NNS	NNS	_	5	nmod	_	_
8	from	from	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	fos	fos	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	jun	jun	NN	NN	_	10	conj	_	_
13	proto-oncogene	proto-oncogene	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	believed	believe	VBN	VBN	_	5	conj	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	cop	_	_
20	important	important	JJ	JJ	_	17	xcomp	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	regulating	regulate	VBG	VBG	_	20	advcl	_	_
23	cell	cell	NN	NN	_	22	dobj	_	_
24	growth	growth	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	23	cc	_	_
26	proliferation	proliferation	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	5	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	oxidants	oxidant	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	believed	believe	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	promote	promote	VB	VB	_	5	xcomp	_	_
8	intestinal	intestinal	JJ	JJ	_	10	amod	_	_
9	epithelial	epithelial	JJ	JJ	_	10	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	the	the	DT	DT	_	18	det	_	_
15	B-cell	b-cell	NN	NN	_	18	compound	_	_
16	lymphoma/leukemia-2	lymphoma/leukemia-2	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	product	product	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	believed	believe	VBN	VBN	_	5	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	inhibit	inhibit	VB	VB	_	20	xcomp	_	_
23	this	this	DT	DT	_	24	det	_	_
24	phenomenon	phenomenon	NN	NN	_	22	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	antioxidant-dependent	antioxidant-dependent	JJ	JJ	_	28	amod	_	_
28	manner	manner	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	observations	observation	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	nontoxic	nontoxic	JJ	JJ	_	9	amod	_	_
9	concentrations	concentration	NNS	NNS	_	17	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	reactive	reactive	JJ	JJ	_	12	amod	_	_
12	metabolites	metabolite	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	oxygen	oxygen	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	nitrogen	nitrogen	NN	NN	_	14	conj	_	_
17	play	play	VBP	VBP	_	6	ccomp	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	regulating	regulate	VBG	VBG	_	17	dep	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	genes	gene	NNS	NNS	_	24	nmod	_	_
27	involved	involve	VBN	VBN	_	26	acl	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	inflammatory	inflammatory	JJ	JJ	_	31	amod	_	_
31	response	response	NN	NN	_	27	nmod	_	_
32	and	and	CC	CC	_	22	cc	_	_
33	in	in	IN	IN	_	34	mark	_	_
34	modulating	modulate	VBG	VBG	_	22	conj	_	_
35	apoptosis	apoptosis	NN	NN	_	34	dobj	_	_
36	.	.	.	.	_	1	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	fibromyalgia	fibromyalgia	NN	NN	_	2	appos	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	low	low	JJ	JJ	_	8	amod	_	_
7	back	back	JJ	JJ	_	8	amod	_	_
8	pain	pain	NN	NN	_	4	conj	_	_
9	.	.	.	.	_	2	punct	_	_

1	Recently	recently	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	fibromyalgia	fibromyalgia	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	FMS	fms	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	disorder	disorder	NN	NN	_	8	xcomp	_	_
13	associated	associate	VBN	VBN	_	12	acl	_	_
14	with	with	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	altered	altered	JJ	JJ	_	17	amod	_	_
17	functioning	functioning	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	stress	stress	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	system	system	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	FMS	fms	NN	NN	_	2	compound	_	_
2	patients	patient	NNS	NNS	_	3	nsubj	_	_
3	display	display	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	12	det	_	_
5	hyperreactive	hyperreactive	JJ	JJ	_	12	amod	_	_
6	pituitary	pituitary	JJ	JJ	_	5	dep	_	_
7	adrenocorticotropic	adrenocorticotropic	JJ	JJ	_	8	amod	_	_
8	hormone	hormone	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ACTH	acth	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	release	release	NN	NN	_	3	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	corticotropin-releasing	corticotropin-releasing	JJ	JJ	_	17	amod	_	_
17	hormone	hormone	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CRH	crh	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	to	to	TO	TO	_	24	case	_	_
23	insulin-induced	insulin-induced	JJ	JJ	_	24	amod	_	_
24	hypoglycemia	hypoglycemia	NN	NN	_	17	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggested	suggest	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	feedback	feedback	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cortisol	cortisol	NN	NN	_	5	nmod	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	deranged	derange	VBN	VBN	_	2	ccomp	_	_
11	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	properties	property	NNS	NNS	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	function	function	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	GR	gr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	FMS	fms	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	compared	compare	VBD	VBD	_	3	conj	_	_
20	the	the	DT	DT	_	21	det	_	_
21	results	result	NNS	NNS	_	19	dobj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	those	those	DT	DT	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	healthy	healthy	JJ	JJ	_	26	amod	_	_
26	persons	person	NNS	NNS	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	patients	patient	NNS	NNS	_	26	conj	_	_
29	with	with	IN	IN	_	33	case	_	_
30	chronic	chronic	JJ	JJ	_	33	amod	_	_
31	low	low	JJ	JJ	_	33	amod	_	_
32	back	back	JJ	JJ	_	33	amod	_	_
33	pain	pain	NN	NN	_	28	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	LBP	lbp	NN	NN	_	33	appos	_	_
36	a	a	DT	DT	_	39	det	_	_
37	localized	localized	JJ	JJ	_	39	amod	_	_
38	pain	pain	NN	NN	_	39	compound	_	_
39	condition	condition	NN	NN	_	35	dep	_	_
40	)	)	-RRB-	-RRB-	_	35	punct	_	_
41	.	.	.	.	_	3	punct	_	_

1	Forty	forty	CD	CD	_	4	nummod	_	_
2	primary	primary	JJ	JJ	_	4	amod	_	_
3	FMS	fms	NN	NN	_	4	compound	_	_
4	patients	patient	NNS	NNS	_	36	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	F	f	NN	NN	_	8	compound	_	_
7	:	:	:	:	_	8	punct	_	_
8	M	m	NN	NN	_	4	dep	_	_
9	=	=	JJ	JJ	_	8	amod	_	_
10	36	36	CD	CD	_	12	nummod	_	_
11	:	:	:	:	_	12	punct	_	_
12	4	4	CD	CD	_	9	dep	_	_
13	)	)	-RRB-	-RRB-	_	8	punct	_	_
14	,	,	,	,	_	4	punct	_	_
15	28	28	CD	CD	_	17	nummod	_	_
16	LBP	lbp	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	4	conj	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	25	25	CD	CD	_	21	nummod	_	_
20	:	:	:	:	_	21	punct	_	_
21	3	3	CD	CD	_	17	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	4	cc	_	_
24	14	14	CD	CD	_	34	nummod	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	12	12	CD	CD	_	28	nummod	_	_
27	:	:	:	:	_	28	punct	_	_
28	2	2	CD	CD	_	24	dep	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	healthy	healthy	JJ	JJ	_	34	amod	_	_
31	,	,	,	,	_	30	punct	_	_
32	sedentary	sedentary	JJ	JJ	_	30	dep	_	_
33	control	control	JJ	JJ	_	34	amod	_	_
34	persons	person	NNS	NNS	_	4	conj	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	recruited	recruit	VBN	VBN	_	0	root	_	_
37	for	for	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	study	study	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	36	punct	_	_

1	Urinary	urinary	JJ	JJ	_	4	amod	_	_
2	free	free	JJ	JJ	_	4	amod	_	_
3	cortisol	cortisol	NN	NN	_	4	compound	_	_
4	excretion	excretion	NN	NN	_	11	nsubj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	FMS	fms	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	LBP	lbp	NN	NN	_	6	conj	_	_
9	patients	patient	NNS	NNS	_	6	dep	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	lower	lower	JJR	JJR	_	0	root	_	_
12	compared	compare	VBN	VBN	_	14	case	_	_
13	to	to	TO	TO	_	14	case	_	_
14	controls	control	NNS	NNS	_	11	advcl	_	_
15	.	.	.	.	_	11	punct	_	_

1	Only	only	RB	RB	_	3	advmod	_	_
2	FMS	fms	NN	NN	_	3	compound	_	_
3	patients	patient	NNS	NNS	_	4	nsubj	_	_
4	displayed	display	VBD	VBD	_	0	root	_	_
5	lower	lower	JJR	JJR	_	6	amod	_	_
6	CBG	cbg	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	basal	basal	JJ	JJ	_	11	amod	_	_
9	serum	serum	NN	NN	_	11	compound	_	_
10	cortisol	cortisol	NN	NN	_	11	compound	_	_
11	concentrations	concentration	NNS	NNS	_	6	conj	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	compared	compare	VBN	VBN	_	4	advcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	controls	control	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	plasma	plasma	NN	NN	_	6	compound	_	_
4	free	free	JJ	JJ	_	6	amod	_	_
5	cortisol	cortisol	NN	NN	_	6	compound	_	_
6	concentrations	concentration	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	similar	similar	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	three	three	CD	CD	_	12	nummod	_	_
12	groups	group	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	difference	difference	NN	NN	_	2	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	number	number	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GR	gr	NN	NN	_	7	nmod	_	_
10	per	per	IN	IN	_	11	case	_	_
11	cell	cell	NN	NN	_	7	nmod	_	_
12	among	among	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	three	three	CD	CD	_	15	nummod	_	_
15	groups	group	NNS	NNS	_	4	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	FMS	fms	NN	NN	_	4	dep	_	_
18	:	:	:	:	_	17	punct	_	_
19	6498	6498	CD	CD	_	17	dep	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	252	252	CD	CD	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	LBP	lbp	NN	NN	_	17	appos	_	_
24	:	:	:	:	_	23	punct	_	_
25	6625	6625	CD	CD	_	23	dep	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	284	284	CD	CD	_	25	conj	_	_
28	,	,	,	,	_	17	punct	_	_
29	controls	control	NNS	NNS	_	17	appos	_	_
30	:	:	:	:	_	29	punct	_	_
31	6576	6576	CD	CD	_	29	dep	_	_
32	+/-	+/-	CC	CC	_	31	cc	_	_
33	304	304	CD	CD	_	31	conj	_	_
34	)	)	-RRB-	-RRB-	_	17	punct	_	_
35	,	,	,	,	_	2	punct	_	_
36	but	but	CC	CC	_	2	cc	_	_
37	the	the	DT	DT	_	39	det	_	_
38	dissociation	dissociation	NN	NN	_	39	compound	_	_
39	constant	constant	NN	NN	_	63	nsubj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	Kd	kd	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	of	of	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	dep	_	_
45	FMS	fms	NN	NN	_	39	nmod	_	_
46	(	(	-LRB-	-LRB-	_	50	punct	_	_
47	14.5	14.5	CD	CD	_	50	nummod	_	_
48	+/-	+/-	CC	CC	_	47	cc	_	_
49	0.9	0.9	CD	CD	_	47	conj	_	_
50	nmol/l	nmol/l	NN	NN	_	45	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	and	and	CC	CC	_	45	cc	_	_
53	LBP	lbp	NN	NN	_	45	conj	_	_
54	(	(	-LRB-	-LRB-	_	58	punct	_	_
55	14.7	14.7	CD	CD	_	58	nummod	_	_
56	+/-	+/-	CC	CC	_	55	cc	_	_
57	1.3	1.3	CD	CD	_	55	conj	_	_
58	nmol/l	nmol/l	NN	NN	_	53	appos	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	subjects	subject	NNS	NNS	_	45	dep	_	_
61	was	be	VBD	VBD	_	63	cop	_	_
62	significantly	significantly	RB	RB	_	63	advmod	_	_
63	higher	higher	JJR	JJR	_	2	conj	_	_
64	than	than	IN	IN	_	65	case	_	_
65	that	that	DT	DT	_	63	nmod	_	_
66	of	of	IN	IN	_	68	case	_	_
67	the	the	DT	DT	_	68	det	_	_
68	controls	control	NNS	NNS	_	65	nmod	_	_
69	(	(	-LRB-	-LRB-	_	73	punct	_	_
70	10.9	10.9	CD	CD	_	73	nummod	_	_
71	+/-	+/-	CC	CC	_	70	cc	_	_
72	0.8	0.8	CD	CD	_	70	conj	_	_
73	nmol/l	nmol/l	NN	NN	_	65	appos	_	_
74	)	)	-RRB-	-RRB-	_	73	punct	_	_
75	(	(	-LRB-	-LRB-	_	76	punct	_	_
76	p	p	NN	NN	_	63	dep	_	_
77	&lt;	&lt;	JJR	JJR	_	76	amod	_	_
78	.05	.05	CD	CD	_	77	dep	_	_
79	)	)	-RRB-	-RRB-	_	76	punct	_	_
80	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	maximal	maximal	JJ	JJ	_	3	amod	_	_
3	stimulation	stimulation	NN	NN	_	29	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	measured	measure	VBN	VBN	_	29	dep	_	_
10	by	by	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	maximal	maximal	JJ	JJ	_	14	amod	_	_
13	thymidine	thymidine	NN	NN	_	14	compound	_	_
14	incorporation	incorporation	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	absence	absence	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cortisol	cortisol	NN	NN	_	18	nmod	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	FMS	fms	NN	NN	_	25	compound	_	_
25	group	group	NN	NN	_	9	nmod	_	_
26	was	be	VBD	VBD	_	29	cop	_	_
27	approximately	approximately	RB	RB	_	29	advmod	_	_
28	1.5	1.5	CD	CD	_	29	compound	_	_
29	times	time	NNS	NNS	_	0	root	_	_
30	higher	higher	JJR	JJR	_	29	dep	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	p	p	NN	NN	_	29	dep	_	_
33	&lt;	&lt;	JJR	JJR	_	32	amod	_	_
34	.05	.05	CD	CD	_	33	dep	_	_
35	)	)	-RRB-	-RRB-	_	32	punct	_	_
36	than	than	IN	IN	_	39	case	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	dep	_	_
39	control	control	JJ	JJ	_	29	nmod	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	LBP	lbp	NN	NN	_	42	compound	_	_
42	group	group	NN	NN	_	39	conj	_	_
43	.	.	.	.	_	29	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ED50	ed50	NN	NN	_	20	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	cortisol	cortisol	NN	NN	_	6	compound	_	_
6	concentration	concentration	NN	NN	_	2	dep	_	_
7	giving	give	VBG	VBG	_	6	acl	_	_
8	50	50	CD	CD	_	9	compound	_	_
9	%	%	NN	NN	_	10	amod	_	_
10	inhibition	inhibition	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	thymidine	thymidine	JJ	JJ	_	14	amod	_	_
14	incorporation	incorporation	NN	NN	_	10	nmod	_	_
15	)	)	-RRB-	-RRB-	_	6	punct	_	_
16	,	,	,	,	_	2	punct	_	_
17	however	however	RB	RB	_	20	advmod	_	_
18	,	,	,	,	_	20	punct	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	identical	identical	JJ	JJ	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	all	all	DT	DT	_	24	det	_	_
23	three	three	CD	CD	_	24	nummod	_	_
24	groups	group	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	FMS	fms	NN	NN	_	5	compound	_	_
5	patients	patient	NNS	NNS	_	6	nsubj	_	_
6	have	have	VBP	VBP	_	2	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	mild	mild	JJ	JJ	_	9	amod	_	_
9	hypocortisolemia	hypocortisolemia	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	increased	increase	VBN	VBN	_	14	amod	_	_
12	cortisol	cortisol	NN	NN	_	14	compound	_	_
13	feedback	feedback	NN	NN	_	14	compound	_	_
14	resistance	resistance	NN	NN	_	9	appos	_	_
15	in	in	IN	IN	_	16	case	_	_
16	combination	combination	NN	NN	_	9	nmod	_	_
17	probably	probably	RB	RB	_	21	advmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	reduced	reduce	VBN	VBN	_	21	amod	_	_
21	CRH	crh	NN	NN	_	16	nmod	_	_
22	synthesis	synthesis	NN	NN	_	21	dep	_	_
23	or	or	CC	CC	_	21	cc	_	_
24	release	release	NN	NN	_	21	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	hypothalamus	hypothalamus	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	GR	gr	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	mineralocorticoid	mineralocorticoid	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	5	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MR	mr	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CRH	crh	NN	NN	_	15	compound	_	_
15	regulation	regulation	NN	NN	_	2	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	FMS	fms	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	15	nmod	_	_
20	remains	remain	VBZ	VBZ	_	0	root	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	solved	solve	VBN	VBN	_	20	xcomp	_	_
24	.	.	.	.	_	20	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	0	root	_	_
3	required	require	VBN	VBN	_	2	acl	_	_
4	for	for	IN	IN	_	7	case	_	_
5	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
6	lineage	lineage	NN	NN	_	7	compound	_	_
7	commitment	commitment	NN	NN	_	3	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Intimate	intimate	JJ	JJ	_	2	amod	_	_
2	interactions	interaction	NNS	NNS	_	11	nsubj	_	_
3	between	between	IN	IN	_	7	case	_	_
4	multipotential	multipotential	JJ	JJ	_	7	amod	_	_
5	hemopoietic	hemopoietic	JJ	JJ	_	7	amod	_	_
6	stem	stem	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
10	microenvironment	microenvironment	NN	NN	_	7	conj	_	_
11	work	work	VBP	VBP	_	0	root	_	_
12	towards	towards	IN	IN	_	13	mark	_	_
13	redefining	redefine	VBG	VBG	_	11	advcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	identity	identity	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	differentiative	differentiative	JJ	JJ	_	19	amod	_	_
19	fate	fate	NN	NN	_	15	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	these	these	DT	DT	_	23	det	_	_
22	primitive	primitive	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	cues	cue	NNS	NNS	_	8	nsubj	_	_
3	delivered	deliver	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	microenvironment	microenvironment	NN	NN	_	3	nmod	_	_
7	frequently	frequently	RB	RB	_	8	advmod	_	_
8	act	act	VBP	VBP	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	instructive	instructive	JJ	JJ	_	12	amod	_	_
12	fashion	fashion	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	initiating	initiate	VBG	VBG	_	8	advcl	_	_
15	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	pathways	pathway	NNS	NNS	_	14	dobj	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	ultimately	ultimately	RB	RB	_	20	advmod	_	_
20	target	target	VBP	VBP	_	17	acl:relcl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	select	select	JJ	JJ	_	23	amod	_	_
23	group	group	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	regulators	regulator	NNS	NNS	_	6	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	turn	turn	NN	NN	_	6	nmod	_	_
6	trigger	trigger	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	cascade	cascade	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	genetic	genetic	JJ	JJ	_	11	amod	_	_
11	changes	change	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	ultimately	ultimately	RB	RB	_	14	advmod	_	_
14	determine	determine	VBP	VBP	_	11	acl:relcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	course	course	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	during	during	IN	IN	_	21	case	_	_
21	differentiation	differentiation	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Gene	gene	NN	NN	_	3	compound	_	_
2	inactivation	inactivation	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	13	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	PU.1	pu.1	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	Ikaros	ikaros	NN	NN	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	GATA-3	gata-3	NN	NN	_	6	conj	_	_
11	genes	gene	NNS	NNS	_	6	dep	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	revealed	reveal	VBN	VBN	_	0	root	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	encoded	encode	VBN	VBN	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	19	nsubj	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	essential	essential	JJ	JJ	_	13	ccomp	_	_
20	for	for	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	earliest	earliest	JJS	JJS	_	24	amod	_	_
23	commitment	commitment	NN	NN	_	24	compound	_	_
24	step	step	NN	NN	_	19	nmod	_	_
25	into	into	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	dep	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	T	t	NN	NN	_	27	conj	_	_
30	lymphoid	lymphoid	JJ	JJ	_	31	amod	_	_
31	lineages	lineage	NNS	NNS	_	27	dep	_	_
32	.	.	.	.	_	13	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	rescue	rescue	NN	NN	_	11	nsubjpass	_	_
3	from	from	IN	IN	_	6	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	nmod:npmod	_	_
5	induced	induced	JJ	JJ	_	6	amod	_	_
6	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	0	root	_	_
12	through	through	IN	IN	_	13	case	_	_
13	inhibition	inhibition	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	IkappaBalpha	ikappabalpha	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	dexamethasone	dexamethasone	NN	NN	_	14	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	DEX	dex	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	synthetic	synthetic	JJ	JJ	_	12	amod	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	5	appos	_	_
13	,	,	,	,	_	5	punct	_	_
14	causes	cause	VBZ	VBZ	_	3	ccomp	_	_
15	apoptosis	apoptosis	NN	NN	_	14	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	mature	mature	JJ	JJ	_	20	amod	_	_
18	Th	th	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	that	that	IN	IN	_	30	mark	_	_
24	this	this	DT	DT	_	25	det	_	_
25	induction	induction	NN	NN	_	30	nsubjpass	_	_
26	of	of	IN	IN	_	28	case	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	death	death	NN	NN	_	25	nmod	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	prevented	prevent	VBN	VBN	_	14	conj	_	_
31	by	by	IN	IN	_	33	case	_	_
32	specific	specific	JJ	JJ	_	33	amod	_	_
33	cytokines	cytokine	NNS	NNS	_	35	nmod	_	_
34	,	,	,	,	_	35	punct	_	_
35	namely	namely	RB	RB	_	30	advcl	_	_
36	,	,	,	,	_	35	punct	_	_
37	by	by	IN	IN	_	38	case	_	_
38	IL-2	il-2	NN	NN	_	35	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	Th1	th1	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	by	by	IN	IN	_	44	case	_	_
44	IL-4	il-4	NN	NN	_	38	conj	_	_
45	in	in	IN	IN	_	47	case	_	_
46	Th2	th2	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	44	nmod	_	_
48	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	this	this	DT	DT	_	7	det	_	_
6	differential	differential	JJ	JJ	_	7	amod	_	_
7	rescue	rescue	NN	NN	_	14	nsubj	_	_
8	by	by	IN	IN	_	10	case	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	cytokines	cytokine	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	Th	th	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	correlates	correlate	VBZ	VBZ	_	3	ccomp	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	level	level	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IkappaBalpha	ikappabalpha	NN	NN	_	17	nmod	_	_
20	that	that	WDT	WDT	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	regulated	regulate	VBN	VBN	_	19	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	DEX	dex	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	cytokines	cytokine	NNS	NNS	_	24	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	both	both	DT	DT	_	4	det	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	types	type	NNS	NNS	_	14	nmod	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	IkappaBalpha	ikappabalpha	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	protein	protein	NN	NN	_	10	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	evaluated	evaluate	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	DEX	dex	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Interestingly	interestingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	DEX-mediated	dex-mediated	JJ	JJ	_	6	amod	_	_
5	IkappaBalpha	ikappabalpha	NN	NN	_	6	compound	_	_
6	induction	induction	NN	NN	_	9	nsubjpass	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IL-2	il-2	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	11	cc	_	_
15	IL-4	il-4	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	Th1	th1	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	while	while	IN	IN	_	26	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	reverse	reverse	NN	NN	_	24	compound	_	_
24	profile	profile	NN	NN	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	seen	see	VBN	VBN	_	9	advcl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	Th2	th2	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	both	both	DT	DT	_	4	det	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	types	type	NNS	NNS	_	18	nmod	_	_
5	,	,	,	,	_	18	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	cytokine	cytokine	NN	NN	_	18	nsubj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	inhibits	inhibit	VBZ	VBZ	_	7	acl:relcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IkappaBalpha	ikappabalpha	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	DEX	dex	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	rescues	rescue	VBZ	VBZ	_	0	root	_	_
19	these	these	DT	DT	_	20	det	_	_
20	cells	cell	NNS	NNS	_	18	dobj	_	_
21	from	from	IN	IN	_	23	case	_	_
22	DEX-induced	dex-induced	JJ	JJ	_	23	amod	_	_
23	apoptosis	apoptosis	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	although	although	IN	IN	_	30	mark	_	_
26	the	the	DT	DT	_	28	det	_	_
27	rescue	rescue	NN	NN	_	28	compound	_	_
28	cytokine	cytokine	NN	NN	_	30	nsubj	_	_
29	is	be	VBZ	VBZ	_	30	cop	_	_
30	different	different	JJ	JJ	_	18	advcl	_	_
31	in	in	IN	IN	_	32	case	_	_
32	Th1	th1	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	Th2	th2	NN	NN	_	32	conj	_	_
35	cells	cell	NNS	NNS	_	32	dep	_	_
36	.	.	.	.	_	18	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	need	need	VBP	VBP	_	3	ccomp	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	maintain	maintain	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	certain	certain	JJ	JJ	_	12	amod	_	_
12	level	level	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	mark	_	_
18	order	order	NN	NN	_	17	mwe	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	survive	survive	VB	VB	_	7	advcl	_	_
21	;	;	:	:	_	3	punct	_	_
22	up-	up-	JJ	JJ	_	39	nsubj	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	down-regulation	down-regulation	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
27	NF	nf	NN	NN	_	28	compound	_	_
28	kappaB	kappab	NN	NN	_	22	nmod	_	_
29	through	through	IN	IN	_	30	case	_	_
30	modulation	modulation	NN	NN	_	22	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	IkappaBalpha	ikappabalpha	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	30	nmod	_	_
34	by	by	IN	IN	_	35	case	_	_
35	cytokines	cytokine	NNS	NNS	_	33	nmod	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	DEX	dex	NN	NN	_	35	conj	_	_
38	may	may	MD	MD	_	39	aux	_	_
39	lead	lead	VB	VB	_	3	parataxis	_	_
40	to	to	TO	TO	_	42	case	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	survival	survival	NN	NN	_	39	nmod	_	_
43	or	or	CC	CC	_	42	cc	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	death	death	NN	NN	_	42	conj	_	_
46	,	,	,	,	_	39	punct	_	_
47	respectively	respectively	RB	RB	_	39	advmod	_	_
48	.	.	.	.	_	3	punct	_	_

1	Genes	gene	NNS	NNS	_	0	root	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	regulate	regulate	VBP	VBP	_	1	acl:relcl	_	_
4	interleukin-4	interleukin-4	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	an	a	DT	DT	_	5	det	_	_
4	immunomodulatory	immunomodulatory	JJ	JJ	_	5	amod	_	_
5	cytokine	cytokine	NN	NN	_	0	root	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	plays	play	VBZ	VBZ	_	5	acl:relcl	_	_
8	a	a	DT	DT	_	10	det	_	_
9	central	central	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	allergic	allergic	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	atopic	atopic	JJ	JJ	_	15	conj	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	responses	response	NNS	NNS	_	15	dep	_	_
20	.	.	.	.	_	5	punct	_	_

1	Significant	significant	JJ	JJ	_	2	amod	_	_
2	progress	progress	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	made	make	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	mark	_	_
7	gaining	gain	VBG	VBG	_	5	advcl	_	_
8	a	a	DT	DT	_	10	det	_	_
9	detailed	detailed	JJ	JJ	_	10	amod	_	_
10	understanding	understanding	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	regulation	regulation	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	interleukin-4	interleukin-4	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	dep	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	identification	identification	NN	NN	_	12	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	characterization	characterization	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	several	several	JJ	JJ	_	10	amod	_	_
8	key	key	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	3	nmod	_	_
11	has	have	VBZ	VBZ	_	12	aux	_	_
12	helped	help	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	elucidate	elucidate	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	mechanisms	mechanism	NNS	NNS	_	14	dobj	_	_
18	of	of	IN	IN	_	24	case	_	_
19	T	t	NN	NN	_	23	compound	_	_
20	helper	helper	NN	NN	_	23	compound	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	cytokine	cytokine	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	Xenogeneic	xenogeneic	JJ	JJ	_	3	amod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	serum	serum	NN	NN	_	4	nsubj	_	_
4	promotes	promote	VBZ	VBZ	_	0	root	_	_
5	leukocyte	leukocyte	NN	NN	_	6	compound	_	_
6	adhesion	adhesion	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	porcine	porcine	NN	NN	_	9	compound	_	_
9	endothelium	endothelium	NN	NN	_	6	nmod	_	_
10	under	under	IN	IN	_	12	case	_	_
11	flow	flow	NN	NN	_	12	compound	_	_
12	conditions	condition	NNS	NNS	_	4	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	possibly	possibly	RB	RB	_	17	advmod	_	_
15	through	through	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	4	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	transcription	transcription	NN	NN	_	23	compound	_	_
21	factor	factor	NN	NN	_	23	compound	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Endothelial	endothelial	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	leukocyte	leukocyte	NN	NN	_	6	compound	_	_
6	infiltration	infiltration	NN	NN	_	3	conj	_	_
7	are	be	VBP	VBP	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	consistent	consistent	JJ	JJ	_	10	amod	_	_
10	feature	feature	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	discordant	discordant	JJ	JJ	_	14	amod	_	_
13	xenograft	xenograft	NN	NN	_	14	compound	_	_
14	rejection	rejection	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	evaluated	evaluate	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	18	mark	_	_
5	xenogeneic	xenogeneic	JJ	JJ	_	6	amod	_	_
6	serum	serum	NN	NN	_	18	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	as	as	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	source	source	NN	NN	_	18	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	xenoreactive	xenoreactive	JJ	JJ	_	14	amod	_	_
13	natural	natural	JJ	JJ	_	14	amod	_	_
14	antibodies	antibody	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	complement	complement	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	18	punct	_	_
18	induced	induce	VBD	VBD	_	3	ccomp	_	_
19	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	18	dobj	_	_
22	with	with	IN	IN	_	25	case	_	_
23	consequent	consequent	JJ	JJ	_	25	amod	_	_
24	leukocyte	leukocyte	NN	NN	_	25	compound	_	_
25	adhesion	adhesion	NN	NN	_	18	nmod	_	_
26	under	under	IN	IN	_	28	case	_	_
27	flow	flow	NN	NN	_	28	compound	_	_
28	conditions	condition	NNS	NNS	_	18	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Porcine	porcine	JJ	JJ	_	4	amod	_	_
2	aortic	aortic	JJ	JJ	_	4	amod	_	_
3	endothelial	endothelial	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PAEC	paec	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	incubated	incubate	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	14	case	_	_
11	1	1	CD	CD	_	14	nummod	_	_
12	hr	hr	NN	NN	_	14	compound	_	_
13	30	30	CD	CD	_	14	nummod	_	_
14	min	min	NN	NN	_	9	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	5	5	CD	CD	_	17	nummod	_	_
17	hr	hr	NN	NN	_	14	conj	_	_
18	with	with	IN	IN	_	23	case	_	_
19	10	10	CD	CD	_	20	compound	_	_
20	%	%	NN	NN	_	23	amod	_	_
21	homologous	homologous	JJ	JJ	_	23	amod	_	_
22	porcine	porcine	JJ	JJ	_	23	amod	_	_
23	serum	serum	NN	NN	_	9	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	control	control	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	or	or	CC	CC	_	23	cc	_	_
28	10	10	CD	CD	_	29	compound	_	_
29	%	%	NN	NN	_	32	amod	_	_
30	xenogeneic	xenogeneic	JJ	JJ	_	32	amod	_	_
31	human	human	JJ	JJ	_	32	amod	_	_
32	serum	serum	NN	NN	_	23	conj	_	_
33	and	and	CC	CC	_	9	cc	_	_
34	then	then	RB	RB	_	35	advmod	_	_
35	perfused	perfuse	VBN	VBN	_	9	conj	_	_
36	with	with	IN	IN	_	39	case	_	_
37	total	total	JJ	JJ	_	39	amod	_	_
38	human	human	JJ	JJ	_	39	amod	_	_
39	leukocytes	leukocyte	NNS	NNS	_	35	nmod	_	_
40	in	in	IN	IN	_	45	case	_	_
41	a	a	DT	DT	_	45	det	_	_
42	parallel	parallel	NN	NN	_	45	compound	_	_
43	plate	plate	NN	NN	_	45	compound	_	_
44	flow	flow	NN	NN	_	45	compound	_	_
45	chamber	chamber	NN	NN	_	35	nmod	_	_
46	under	under	IN	IN	_	48	case	_	_
47	laminar	laminar	JJ	JJ	_	48	amod	_	_
48	flow	flow	NN	NN	_	35	nmod	_	_
49	(	(	-LRB-	-LRB-	_	51	punct	_	_
50	1.5	1.5	CD	CD	_	51	nummod	_	_
51	dynes/cm2	dynes/cm2	NNS	NNS	_	48	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	9	punct	_	_

1	Adherent	adherent	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	counted	count	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	digital	digital	JJ	JJ	_	8	amod	_	_
7	image	image	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Xenogeneic	xenogeneic	JJ	JJ	_	3	amod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	serum	serum	NN	NN	_	10	nsubj	_	_
4	significantly	significantly	RB	RB	_	10	advmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	P	p	NN	NN	_	4	dep	_	_
7	&lt;	&lt;	JJR	JJR	_	6	amod	_	_
8	0.01	0.01	CD	CD	_	7	dep	_	_
9	)	)	-RRB-	-RRB-	_	6	punct	_	_
10	increased	increase	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	adherent	adherent	JJ	JJ	_	15	amod	_	_
15	leukocytes	leukocyte	NNS	NNS	_	12	nmod	_	_
16	as	as	IN	IN	_	17	mark	_	_
17	compared	compare	VBN	VBN	_	10	advcl	_	_
18	with	with	IN	IN	_	20	case	_	_
19	porcine	porcine	JJ	JJ	_	20	amod	_	_
20	serum	serum	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	similar	similar	JJ	JJ	_	4	amod	_	_
3	adhesive	adhesive	JJ	JJ	_	2	dep	_	_
4	response	response	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	elicited	elicit	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	TNF	tnf	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	100	100	CD	CD	_	12	nummod	_	_
12	U/ml	u/ml	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	9	punct	_	_
15	one	one	CD	CD	_	9	appos	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	most	most	RBS	RBS	_	19	advmod	_	_
19	potent	potent	JJ	JJ	_	20	amod	_	_
20	inducers	inducer	NNS	NNS	_	15	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	adhesive	adhesive	JJ	JJ	_	25	amod	_	_
25	properties	property	NNS	NNS	_	20	nmod	_	_
26	,	,	,	,	_	15	punct	_	_
27	here	here	RB	RB	_	28	advmod	_	_
28	used	use	VBN	VBN	_	15	acl	_	_
29	as	as	IN	IN	_	31	case	_	_
30	positive	positive	JJ	JJ	_	31	amod	_	_
31	control	control	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	elucidate	elucidate	VB	VB	_	16	advcl	_	_
5	possible	possible	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
7	underlying	underlie	VBG	VBG	_	6	acl	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	by	by	IN	IN	_	13	case	_	_
12	xenogeneic	xenogeneic	JJ	JJ	_	13	amod	_	_
13	serum	serum	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	focussed	focus	VBD	VBD	_	0	root	_	_
17	on	on	IN	IN	_	21	case	_	_
18	transcription	transcription	NN	NN	_	21	compound	_	_
19	factor	factor	NN	NN	_	21	compound	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	25	det	_	_
24	central	central	JJ	JJ	_	25	amod	_	_
25	regulator	regulator	NN	NN	_	21	appos	_	_
26	for	for	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	induction	induction	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	genes	gene	NNS	NNS	_	28	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	including	include	VBG	VBG	_	35	case	_	_
34	adhesive	adhesive	JJ	JJ	_	35	amod	_	_
35	molecules	molecule	NNS	NNS	_	31	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	chemoattractants	chemoattractant	NNS	NNS	_	35	conj	_	_
38	.	.	.	.	_	16	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	confocal	confocal	JJ	JJ	_	4	amod	_	_
3	fluorescence	fluorescence	NN	NN	_	4	compound	_	_
4	microscopy	microscopy	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	observed	observe	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	positive	positive	JJ	JJ	_	10	amod	_	_
10	staining	staining	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	p65	p65	NN	NN	_	16	compound	_	_
16	subunit	subunit	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nuclei	nucleus	NNS	NNS	_	7	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	PAEC	paec	NNS	NNS	_	20	nmod	_	_
23	exposed	expose	VBN	VBN	_	22	acl	_	_
24	for	for	IN	IN	_	28	case	_	_
25	1	1	CD	CD	_	28	nummod	_	_
26	hr	hr	NN	NN	_	28	compound	_	_
27	30	30	CD	CD	_	28	nummod	_	_
28	min	min	NN	NN	_	23	nmod	_	_
29	to	to	TO	TO	_	31	case	_	_
30	human	human	JJ	JJ	_	31	amod	_	_
31	serum	serum	NN	NN	_	23	nmod	_	_
32	,	,	,	,	_	7	punct	_	_
33	which	which	WDT	WDT	_	34	nsubj	_	_
34	indicated	indicate	VBD	VBD	_	7	dep	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	34	dobj	_	_
38	in	in	IN	IN	_	40	case	_	_
39	this	this	DT	DT	_	40	det	_	_
40	setting	setting	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	7	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	variance	variance	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	in	in	IN	IN	_	5	case	_	_
5	PAEC	paec	NNS	NNS	_	16	nmod	_	_
6	incubated	incubate	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	homologous	homologous	JJ	JJ	_	10	amod	_	_
10	serum	serum	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	16	punct	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	16	nsubj	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	strictly	strictly	RB	RB	_	16	advmod	_	_
16	localized	localized	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	cytoplasm	cytoplasm	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	Treatment	treatment	NN	NN	_	34	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PAEC	paec	NNS	NNS	_	1	nmod	_	_
4	exposed	expose	VBN	VBN	_	3	acl	_	_
5	to	to	TO	TO	_	7	case	_	_
6	xenogeneic	xenogeneic	JJ	JJ	_	7	amod	_	_
7	serum	serum	NN	NN	_	4	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	inhibitors	inhibitor	NNS	NNS	_	1	nmod	_	_
13	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NN	NN	_	12	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PDTC	pdtc	NN	NN	_	13	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	25	25	CD	CD	_	18	nummod	_	_
18	microM	microm	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	15	punct	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	tosyl-phechloromethylketone	tosyl-phechloromethylketone	NN	NN	_	13	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	TPCK	tpck	NN	NN	_	21	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	25	25	CD	CD	_	26	nummod	_	_
26	microM	microm	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	23	punct	_	_
28	significantly	significantly	RB	RB	_	34	advmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	P	p	NN	NN	_	28	dep	_	_
31	&lt;	&lt;	JJR	JJR	_	30	amod	_	_
32	0.01	0.01	CD	CD	_	31	dep	_	_
33	)	)	-RRB-	-RRB-	_	30	punct	_	_
34	reduced	reduce	VBD	VBD	_	0	root	_	_
35	leukocyte	leukocyte	NN	NN	_	36	compound	_	_
36	adhesion	adhesion	NN	NN	_	34	dobj	_	_
37	in	in	IN	IN	_	38	case	_	_
38	respect	respect	NN	NN	_	34	nmod	_	_
39	to	to	TO	TO	_	40	case	_	_
40	PAEC	paec	NNS	NNS	_	38	nmod	_	_
41	treated	treat	VBN	VBN	_	40	acl	_	_
42	with	with	IN	IN	_	44	case	_	_
43	human	human	JJ	JJ	_	44	amod	_	_
44	serum	serum	NN	NN	_	41	nmod	_	_
45	alone	alone	RB	RB	_	44	advmod	_	_
46	.	.	.	.	_	34	punct	_	_

1	Findings	finding	NNS	NNS	_	15	nsubj	_	_
2	that	that	IN	IN	_	5	mark	_	_
3	xenogeneic	xenogeneic	JJ	JJ	_	4	amod	_	_
4	serum	serum	NN	NN	_	5	nsubj	_	_
5	promotes	promote	VBZ	VBZ	_	1	ccomp	_	_
6	leukocyte-endothelium	leukocyte-endothelium	JJ	JJ	_	7	amod	_	_
7	interaction	interaction	NN	NN	_	5	dobj	_	_
8	possibly	possibly	RB	RB	_	12	advmod	_	_
9	through	through	IN	IN	_	12	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	5	nmod	_	_
13	might	might	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	relevant	relevant	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	17	mark	_	_
17	designing	design	VBG	VBG	_	15	advcl	_	_
18	future	future	JJ	JJ	_	20	amod	_	_
19	therapeutic	therapeutic	JJ	JJ	_	18	dep	_	_
20	strategies	strategy	NNS	NNS	_	17	dobj	_	_
21	aimed	aim	VBN	VBN	_	20	acl	_	_
22	at	at	IN	IN	_	23	mark	_	_
23	prolonging	prolong	VBG	VBG	_	21	advcl	_	_
24	xenograft	xenograft	NN	NN	_	25	compound	_	_
25	survival	survival	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	15	punct	_	_

1	Delta-opioid	delta-opioid	JJ	JJ	_	2	amod	_	_
2	receptors	receptor	NNS	NNS	_	8	nsubj	_	_
3	expressed	express	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	7	case	_	_
5	Jurkat	jurkat	NN	NN	_	7	compound	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	enhance	enhance	VBP	VBP	_	0	root	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	increasing	increase	VBG	VBG	_	10	acl	_	_
13	AP-1	ap-1	NN	NN	_	14	compound	_	_
14	complexes	complex	NNS	NNS	_	12	dobj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	activity	activity	NN	NN	_	10	conj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	NF-AT/AP-1-binding	nf-at/ap-1-binding	JJ	JJ	_	21	amod	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Recent	recent	JJ	JJ	_	3	amod	_	_
2	molecular	molecular	JJ	JJ	_	1	dep	_	_
3	evidence	evidence	NN	NN	_	4	nsubj	_	_
4	points	point	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	transient	transient	JJ	JJ	_	4	nmod	_	_
7	and/or	and/or	CC	CC	_	6	cc	_	_
8	stage-specific	stage-specific	JJ	JJ	_	6	conj	_	_
9	expression	expression	NN	NN	_	6	dep	_	_
10	of	of	IN	IN	_	11	case	_	_
11	delta-	delta-	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	kappa-opioid	kappa-opioid	JJ	JJ	_	11	conj	_	_
14	receptors	receptor	NNS	NNS	_	11	dep	_	_
15	by	by	IN	IN	_	16	case	_	_
16	thymic	thymic	JJ	JJ	_	6	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
19	T	t	NN	NN	_	16	conj	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	16	dep	_	_
21	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	7	mark	_	_
2	medical	medical	JJ	JJ	_	3	amod	_	_
3	treatments	treatment	NNS	NNS	_	7	nsubj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	stress	stress	NN	NN	_	3	conj	_	_
6	commonly	commonly	RB	RB	_	7	advmod	_	_
7	increase	increase	VBP	VBP	_	13	advcl	_	_
8	opioid	opioid	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	,	,	,	,	_	13	punct	_	_
11	it	it	PRP	PRP	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	important	important	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	understand	understand	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	mechanisms	mechanism	NNS	NNS	_	15	dobj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	21	nmod	_	_
20	opioids	opioid	NNS	NNS	_	21	nsubj	_	_
21	affect	affect	VBP	VBP	_	17	acl:relcl	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	lymphocyte	lymphocyte	NN	NN	_	24	compound	_	_
24	functions	function	NNS	NNS	_	21	dobj	_	_
25	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	created	create	VBD	VBD	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	studied	study	VBD	VBD	_	3	conj	_	_
6	a	a	DT	DT	_	9	det	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	3	dobj	_	_
10	expressing	express	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	cloned	clone	VBN	VBN	_	14	amod	_	_
13	delta-opioid	delta-opioid	JJ	JJ	_	14	amod	_	_
14	receptor	receptor	NN	NN	_	10	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	DOR1	dor1	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	3	punct	_	_

1	DOR1	dor1	NN	NN	_	2	compound	_	_
2	ligation	ligation	NN	NN	_	11	nsubj	_	_
3	by	by	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	specific	specific	JJ	JJ	_	7	amod	_	_
6	DOR1	dor1	NN	NN	_	7	compound	_	_
7	agonist	agonist	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	deltorphin	deltorphin	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	2	punct	_	_
11	augmented	augment	VBD	VBD	_	0	root	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	secretion	secretion	NN	NN	_	11	dobj	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	synergizing	synergize	VBG	VBG	_	11	advcl	_	_
16	with	with	IN	IN	_	17	case	_	_
17	signals	signal	NNS	NNS	_	15	nmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	TCR-CD3	tcr-cd3	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	CD28	cd28	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	11	punct	_	_

1	Reporter	reporter	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	constructs	construct	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	used	use	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	map	map	VB	VB	_	5	xcomp	_	_
8	this	this	DT	DT	_	9	det	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	deltorphin	deltorphin	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	AP-1-	ap-1-	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	NF-AT/AP-1-binding	nf-at/ap-1-binding	JJ	JJ	_	14	conj	_	_
17	sites	site	NNS	NNS	_	14	dep	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	DOR1	dor1	NN	NN	_	3	compound	_	_
3	signaling	signaling	NN	NN	_	4	nsubj	_	_
4	increased	increase	VBD	VBD	_	8	advcl	_	_
5	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	deltorphin	deltorphin	NN	NN	_	8	nsubj	_	_
8	enhanced	enhance	VBD	VBD	_	0	root	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NF-AT/AP-1-binding	nf-at/ap-1-binding	JJ	JJ	_	14	amod	_	_
14	site	site	NN	NN	_	10	nmod	_	_
15	via	via	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	mechanism	mechanism	NN	NN	_	8	nmod	_	_
18	independent	independent	JJ	JJ	_	17	amod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	calcineurin	calcineurin	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	distinct	distinct	JJ	JJ	_	18	conj	_	_
23	from	from	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	effects	effect	NNS	NNS	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	elevated	elevated	JJ	JJ	_	28	amod	_	_
28	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Deltorphin	deltorphin	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	accumulation	accumulation	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	AP-1	ap-1	NN	NN	_	9	compound	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	complexes	complex	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	suggesting	suggest	VBG	VBG	_	3	advcl	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	DOR1	dor1	NN	NN	_	14	nsubj	_	_
14	augments	augment	VBZ	VBZ	_	11	ccomp	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	secretion	secretion	NN	NN	_	14	dobj	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	increasing	increase	VBG	VBG	_	14	advcl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	AP-1	ap-1	NN	NN	_	21	compound	_	_
21	component	component	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	NF-AT/AP-1	nf-at/ap-1	NN	NN	_	26	compound	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factor	factor	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	advance	advance	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	understanding	understanding	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	opioid	opioid	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	6	nmod	_	_
10	on	on	IN	IN	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	in	in	IN	IN	_	15	case	_	_
15	addition	addition	NN	NN	_	3	conj	_	_
16	,	,	,	,	_	3	punct	_	_
17	demonstrate	demonstrate	VBP	VBP	_	3	conj	_	_
18	regulation	regulation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	IL-2	il-2	NN	NN	_	18	nmod	_	_
21	synthesis	synthesis	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	secretion	secretion	NN	NN	_	20	conj	_	_
24	by	by	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	novel	novel	JJ	JJ	_	27	amod	_	_
27	mechanism	mechanism	NN	NN	_	18	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	receptor-mediated	receptor-mediated	JJ	JJ	_	31	amod	_	_
30	AP-1	ap-1	NN	NN	_	31	compound	_	_
31	induction	induction	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Pharmacological	pharmacological	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	antigen	antigen	NN	NN	_	5	compound	_	_
5	responsiveness	responsiveness	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	genetically	genetically	RB	RB	_	10	advmod	_	_
8	modified	modify	VBN	VBN	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	chimeric	chimeric	JJ	JJ	_	4	amod	_	_
3	TCR	tcr	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	27	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	comprising	comprise	VBG	VBG	_	4	acl	_	_
7	an	a	DT	DT	_	12	det	_	_
8	anti-hapten	anti-hapten	JJ	JJ	_	12	amod	_	_
9	single-chain	single-chain	JJ	JJ	_	12	amod	_	_
10	Ab	ab	NN	NN	_	12	compound	_	_
11	variable	variable	JJ	JJ	_	12	amod	_	_
12	fragment	fragment	NN	NN	_	6	dobj	_	_
13	fused	fuse	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	transmembrane	transmembrane	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	cytoplasmic	cytoplasmic	JJ	JJ	_	16	conj	_	_
19	regions	region	NNS	NNS	_	13	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	TCR	tcr	NN	NN	_	24	compound	_	_
24	zeta-chain	zeta-chain	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	4	punct	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	used	use	VBN	VBN	_	0	root	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	determine	determine	VB	VB	_	27	xcomp	_	_
30	whether	whether	IN	IN	_	36	mark	_	_
31	the	the	DT	DT	_	33	det	_	_
32	tetracycline-regulatable	tetracycline-regulatable	JJ	JJ	_	33	amod	_	_
33	system	system	NN	NN	_	36	nsubjpass	_	_
34	could	could	MD	MD	_	36	aux	_	_
35	be	be	VB	VB	_	36	auxpass	_	_
36	used	use	VBN	VBN	_	29	ccomp	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	regulate	regulate	VB	VB	_	36	xcomp	_	_
39	gene	gene	NN	NN	_	40	compound	_	_
40	expression	expression	NN	NN	_	38	dobj	_	_
41	in	in	IN	IN	_	43	case	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	27	punct	_	_

1	Jurkat	jurkat	NN	NN	_	3	compound	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	stably	stably	RB	RB	_	6	advmod	_	_
6	transfected	transfect	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	single	single	JJ	JJ	_	10	amod	_	_
10	vector	vector	NN	NN	_	6	nmod	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	15	det	_	_
13	tetracycline	tetracycline	NN	NN	_	15	compound	_	_
14	trans-activator	trans-activator	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	11	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	controlled	control	VBN	VBN	_	15	acl	_	_
18	by	by	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	constitutive	constitutive	JJ	JJ	_	21	amod	_	_
21	promoter	promoter	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	10	punct	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	chimeric	chimeric	JJ	JJ	_	26	amod	_	_
26	TCR	tcr	NN	NN	_	10	conj	_	_
27	,	,	,	,	_	6	punct	_	_
28	under	under	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	control	control	NN	NN	_	6	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	a	a	DT	DT	_	35	det	_	_
33	trans-activator	trans-activator	JJ	JJ	_	35	amod	_	_
34	protein-responsive	protein-responsive	JJ	JJ	_	35	amod	_	_
35	promoter	promoter	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	tetracyclines	tetracycline	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transfected	transfect	VBN	VBN	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	express	express	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	chimeric	chimeric	JJ	JJ	_	17	amod	_	_
17	receptor	receptor	NN	NN	_	14	dobj	_	_
18	on	on	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	surface	surface	NN	NN	_	14	nmod	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	could	could	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	activated	activate	VBN	VBN	_	12	conj	_	_
26	by	by	IN	IN	_	29	case	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	cognate	cognate	JJ	JJ	_	29	amod	_	_
29	Ag	ag	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	12	punct	_	_
31	leading	lead	VBG	VBG	_	12	advcl	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	secretion	secretion	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	IL-2	il-2	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	exposed	expose	VBN	VBN	_	19	advcl	_	_
6	to	to	TO	TO	_	8	case	_	_
7	increasing	increase	VBG	VBG	_	8	amod	_	_
8	concentrations	concentration	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	tetracyclines	tetracycline	NNS	NNS	_	8	nmod	_	_
11	,	,	,	,	_	19	punct	_	_
12	surface	surface	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	19	nsubjpass	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	chimeric	chimeric	JJ	JJ	_	17	amod	_	_
17	receptor	receptor	NN	NN	_	13	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	suppressed	suppress	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	dose-dependent	dose-dependent	JJ	JJ	_	23	amod	_	_
23	manner	manner	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	19	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	this	this	DT	DT	_	27	det	_	_
27	suppression	suppression	NN	NN	_	29	nsubj	_	_
28	was	be	VBD	VBD	_	29	cop	_	_
29	sufficient	sufficient	JJ	JJ	_	19	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	result	result	VB	VB	_	29	xcomp	_	_
32	in	in	IN	IN	_	34	case	_	_
33	complete	complete	JJ	JJ	_	34	amod	_	_
34	loss	loss	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	responsiveness	responsiveness	NN	NN	_	34	nmod	_	_
37	to	to	TO	TO	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	targeted	target	VBN	VBN	_	40	amod	_	_
40	Ag	ag	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	19	punct	_	_

1	Prolonged	prolonged	JJ	JJ	_	2	amod	_	_
2	suppression	suppression	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	trans-gene	trans-gene	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	for	for	IN	IN	_	10	case	_	_
7	up	up	RB	RB	_	9	advmod	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	7	7	CD	CD	_	10	nummod	_	_
10	days	day	NNS	NNS	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	after	after	IN	IN	_	16	mark	_	_
14	doxycycline	doxycycline	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	removed	remove	VBN	VBN	_	12	advcl	_	_
17	from	from	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cultures	culture	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	but	but	CC	CC	_	12	cc	_	_
22	eventual	eventual	JJ	JJ	_	23	amod	_	_
23	recovery	recovery	NN	NN	_	28	nsubj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	surface	surface	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	complete	complete	JJ	JJ	_	12	conj	_	_
29	,	,	,	,	_	28	punct	_	_
30	and	and	CC	CC	_	28	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	absolute	absolute	JJ	JJ	_	33	amod	_	_
33	time	time	NN	NN	_	38	nsubj	_	_
34	to	to	TO	TO	_	35	case	_	_
35	recovery	recovery	NN	NN	_	33	nmod	_	_
36	was	be	VBD	VBD	_	38	cop	_	_
37	directly	directly	RB	RB	_	38	advmod	_	_
38	proportional	proportional	JJ	JJ	_	28	conj	_	_
39	to	to	TO	TO	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	initial	initial	JJ	JJ	_	42	amod	_	_
42	concentration	concentration	NN	NN	_	38	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	drug	drug	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	12	punct	_	_

1	Pharmacologic	pharmacologic	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	trans-gene	trans-gene	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	gene-modified	gene-modified	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	will	will	MD	MD	_	0	root	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	only	only	RB	RB	_	10	dep	_	_
13	facilitate	facilitate	VB	VB	_	10	conj	_	_
14	new	new	JJ	JJ	_	15	amod	_	_
15	approaches	approach	NNS	NNS	_	13	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	study	study	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	different	different	JJ	JJ	_	21	amod	_	_
21	aspects	aspect	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	biology	biology	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	10	punct	_	_
27	but	but	CC	CC	_	10	cc	_	_
28	will	will	MD	MD	_	30	aux	_	_
29	also	also	RB	RB	_	30	advmod	_	_
30	provide	provide	VB	VB	_	10	conj	_	_
31	the	the	DT	DT	_	32	det	_	_
32	basis	basis	NN	NN	_	30	dobj	_	_
33	for	for	IN	IN	_	37	case	_	_
34	new	new	JJ	JJ	_	37	amod	_	_
35	gene	gene	NN	NN	_	37	compound	_	_
36	therapy	therapy	NN	NN	_	37	compound	_	_
37	strategies	strategy	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	10	punct	_	_

1	Human	human	JJ	JJ	_	9	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
3	virus	virus	NN	NN	_	9	compound	_	_
4	type	type	NN	NN	_	9	compound	_	_
5	1	1	CD	CD	_	9	nummod	_	_
6	long	long	JJ	JJ	_	9	amod	_	_
7	terminal	terminal	JJ	JJ	_	9	amod	_	_
8	repeat	repeat	NN	NN	_	9	compound	_	_
9	quasispecies	quasispecy	NNS	NNS	_	10	nsubj	_	_
10	differ	differ	VBP	VBP	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	basal	basal	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	recruitment	recruitment	NN	NN	_	13	conj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	glial	glial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	21	conj	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	generation	generation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	genomic	genomic	JJ	JJ	_	5	amod	_	_
5	diversity	diversity	NN	NN	_	2	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	course	course	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	infection	infection	NN	NN	_	8	nmod	_	_
11	has	have	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	potential	potential	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	affect	affect	VB	VB	_	13	acl	_	_
16	all	all	DT	DT	_	17	det	_	_
17	aspects	aspect	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
20	replication	replication	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	including	include	VBG	VBG	_	23	case	_	_
23	expression	expression	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	proviral	proviral	JJ	JJ	_	27	amod	_	_
27	genome	genome	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	better	better	JJR	JJR	_	5	amod	_	_
5	understanding	understanding	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	impact	impact	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	17	case	_	_
10	long	long	JJ	JJ	_	12	amod	_	_
11	terminal	terminal	JJ	JJ	_	12	amod	_	_
12	repeat	repeat	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LTR	ltr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	sequence	sequence	NN	NN	_	17	compound	_	_
17	diversity	diversity	NN	NN	_	8	nmod	_	_
18	on	on	IN	IN	_	21	case	_	_
19	LTR-directed	ltr-directed	JJ	JJ	_	20	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	8	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	cells	cell	NNS	NNS	_	21	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	dep	_	_
26	central	central	JJ	JJ	_	28	amod	_	_
27	nervous	nervous	JJ	JJ	_	28	amod	_	_
28	system	system	NN	NN	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	CNS	cns	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	immune	immune	JJ	JJ	_	34	amod	_	_
34	system	system	NN	NN	_	28	conj	_	_
35	,	,	,	,	_	2	punct	_	_
36	we	we	PRP	PRP	_	37	nsubj	_	_
37	amplified	amplify	VBD	VBD	_	2	parataxis	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	cloned	clone	VBN	VBN	_	37	conj	_	_
40	LTRs	ltr	NNS	NNS	_	37	dobj	_	_
41	from	from	IN	IN	_	43	case	_	_
42	proviral	proviral	JJ	JJ	_	43	amod	_	_
43	DNA	dna	NN	NN	_	40	nmod	_	_
44	in	in	IN	IN	_	47	case	_	_
45	HIV-1-infected	hiv-1-infected	JJ	JJ	_	47	amod	_	_
46	peripheral	peripheral	JJ	JJ	_	47	amod	_	_
47	blood	blood	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	2	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nineteen	nineteen	CD	CD	_	5	nummod	_	_
5	LTRs	ltr	NNS	NNS	_	2	nmod	_	_
6	cloned	clone	VBN	VBN	_	5	acl	_	_
7	from	from	IN	IN	_	9	case	_	_
8	2	2	CD	CD	_	9	nummod	_	_
9	adult	adult	JJ	JJ	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	3	3	CD	CD	_	12	nummod	_	_
12	pediatric	pediatric	JJ	JJ	_	9	conj	_	_
13	patients	patient	NNS	NNS	_	9	dep	_	_
14	revealed	reveal	VBD	VBD	_	0	root	_	_
15	an	a	DT	DT	_	16	det	_	_
16	average	average	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	33	33	CD	CD	_	20	nummod	_	_
19	nucleotide	nucleotide	NN	NN	_	20	compound	_	_
20	changes	change	NNS	NNS	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	with	with	IN	IN	_	23	case	_	_
23	respect	respect	NN	NN	_	16	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	sequence	sequence	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	LAI	lai	NN	NN	_	30	compound	_	_
30	LTR	ltr	NN	NN	_	26	nmod	_	_
31	)	)	-RRB-	-RRB-	_	23	punct	_	_
32	within	within	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	455-bp	455-bp	JJ	JJ	_	36	amod	_	_
35	U3	u3	NN	NN	_	36	compound	_	_
36	region	region	NN	NN	_	16	nmod	_	_
37	.	.	.	.	_	14	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	11	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	cells	cell	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	neuroglial	neuroglial	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	lymphocytic	lymphocytic	JJ	JJ	_	7	conj	_	_
10	origin	origin	NN	NN	_	7	dep	_	_
11	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	17	mark	_	_
13	some	some	DT	DT	_	17	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	LTRs	ltr	NNS	NNS	_	13	nmod	_	_
17	had	have	VBD	VBD	_	11	ccomp	_	_
18	activities	activity	NNS	NNS	_	17	dobj	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	varied	vary	VBD	VBD	_	18	acl:relcl	_	_
21	significantly	significantly	RB	RB	_	20	advmod	_	_
22	from	from	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	LAI	lai	NN	NN	_	25	compound	_	_
25	LTR	ltr	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	U-373	u-373	NN	NN	_	29	compound	_	_
28	MG	mg	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	34	punct	_	_
31	an	a	DT	DT	_	34	det	_	_
32	astrocytoma	astrocytoma	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	line	line	NN	NN	_	29	dep	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	as	as	RB	RB	_	29	cc	_	_
37	well	well	RB	RB	_	36	mwe	_	_
38	as	as	IN	IN	_	36	mwe	_	_
39	in	in	IN	IN	_	41	case	_	_
40	Jurkat	jurkat	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	29	conj	_	_
42	(	(	-LRB-	-LRB-	_	48	punct	_	_
43	a	a	DT	DT	_	48	det	_	_
44	CD4-	cd4-	JJ	JJ	_	48	amod	_	_
45	positive	positive	JJ	JJ	_	48	amod	_	_
46	lymphocyte	lymphocyte	NN	NN	_	48	compound	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	line	line	NN	NN	_	41	dep	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	.	.	.	.	_	11	punct	_	_

1	While	while	IN	IN	_	13	mark	_	_
2	LTRs	ltr	NNS	NNS	_	13	nsubj	_	_
3	which	which	WDT	WDT	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	2	acl:relcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	highest	highest	JJS	JJS	_	7	amod	_	_
7	activities	activity	NNS	NNS	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	U-373	u-373	NN	NN	_	11	compound	_	_
10	MG	mg	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	yielded	yield	VBD	VBD	_	25	advcl	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	activities	activity	NNS	NNS	_	13	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	Jurkat	jurkat	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	25	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	LTRs	ltr	NNS	NNS	_	25	nsubj	_	_
22	were	be	VBD	VBD	_	25	cop	_	_
23	generally	generally	RB	RB	_	25	advmod	_	_
24	more	more	RBR	RBR	_	25	advmod	_	_
25	active	active	JJ	JJ	_	0	root	_	_
26	in	in	IN	IN	_	28	case	_	_
27	Jurkat	jurkat	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	when	when	WRB	WRB	_	30	advmod	_	_
30	compared	compare	VBN	VBN	_	25	advcl	_	_
31	to	to	TO	TO	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	LAI	lai	NN	NN	_	34	compound	_	_
34	LTR	ltr	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	25	punct	_	_

1	Differences	difference	NNS	NNS	_	6	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	LTR	ltr	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	1	nmod	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	differences	difference	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	recruitment	recruitment	NN	NN	_	8	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	cis-acting	cis-acting	JJ	JJ	_	15	amod	_	_
15	sites	site	NNS	NNS	_	12	nmod	_	_
16	within	within	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	U3	u3	NN	NN	_	19	compound	_	_
19	region	region	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	LTR	ltr	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	as	as	IN	IN	_	25	mark	_	_
25	demonstrated	demonstrate	VBN	VBN	_	6	advcl	_	_
26	by	by	IN	IN	_	30	case	_	_
27	electrophoretic	electrophoretic	JJ	JJ	_	30	amod	_	_
28	mobility	mobility	NN	NN	_	30	compound	_	_
29	shift	shift	NN	NN	_	30	compound	_	_
30	assays	assay	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	naturally	naturally	RB	RB	_	5	advmod	_	_
5	occurring	occur	VBG	VBG	_	7	amod	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	variation	variation	NN	NN	_	8	nsubj	_	_
8	impacted	impacted	JJ	JJ	_	0	root	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	8	dobj	_	_
11	binding	bind	VBG	VBG	_	10	acl	_	_
12	to	to	TO	TO	_	24	case	_	_
13	an	a	DT	DT	_	24	det	_	_
14	activating	activate	VBG	VBG	_	24	amod	_	_
15	transcription	transcription	NN	NN	_	24	compound	_	_
16	factor/cAMP	factor/camp	NN	NN	_	24	compound	_	_
17	response	response	NN	NN	_	24	compound	_	_
18	element	element	NN	NN	_	24	compound	_	_
19	binding	binding	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	ATF/CREB	atf/creb	NN	NN	_	24	compound	_	_
22	)	)	-RRB-	-RRB-	_	24	punct	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	11	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	located	located	JJ	JJ	_	24	dep	_	_
27	between	between	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	dep	_	_
29	LEF-1	lef-1	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	distal	distal	JJ	JJ	_	34	amod	_	_
32	NF-kappaB	nf-kappab	NN	NN	_	34	compound	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factor	factor	NN	NN	_	29	conj	_	_
35	binding	binding	NN	NN	_	36	compound	_	_
36	sites	site	NNS	NNS	_	29	dep	_	_
37	)	)	-RRB-	-RRB-	_	26	punct	_	_
38	that	that	WDT	WDT	_	40	dobj	_	_
39	we	we	PRP	PRP	_	40	nsubj	_	_
40	identified	identify	VBN	VBN	_	24	acl:relcl	_	_
41	in	in	IN	IN	_	43	case	_	_
42	previous	previous	JJ	JJ	_	43	amod	_	_
43	studies	study	NNS	NNS	_	40	nmod	_	_
44	of	of	IN	IN	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	HIV-1	hiv-1	NN	NN	_	47	compound	_	_
47	LTR	ltr	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	LTR	ltr	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	changes	change	NNS	NNS	_	10	nsubj	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	affect	affect	VB	VB	_	3	ccomp	_	_
11	basal	basal	JJ	JJ	_	13	amod	_	_
12	LTR	ltr	NN	NN	_	13	compound	_	_
13	function	function	NN	NN	_	10	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	recruitment	recruitment	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	which	which	WDT	WDT	_	25	nsubj	_	_
20	may	may	MD	MD	_	25	aux	_	_
21	,	,	,	,	_	25	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	turn	turn	NN	NN	_	25	nmod	_	_
24	,	,	,	,	_	25	punct	_	_
25	alter	alter	VB	VB	_	10	ccomp	_	_
26	the	the	DT	DT	_	27	det	_	_
27	course	course	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	viral	viral	JJ	JJ	_	30	amod	_	_
30	replication	replication	NN	NN	_	27	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	cells	cell	NNS	NNS	_	30	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	CNS	cns	NN	NN	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	immune	immune	JJ	JJ	_	38	amod	_	_
37	system	system	NN	NN	_	38	compound	_	_
38	origin	origin	NN	NN	_	34	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	kappaB	kappab	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	1	nmod	_	_
7	attenuates	attenuate	VBZ	VBZ	_	0	root	_	_
8	apoptosis	apoptosis	NN	NN	_	9	compound	_	_
9	resistance	resistance	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Death-inducing	death-inducing	NN	NN	_	2	compound	_	_
2	ligands	ligand	NNS	NNS	_	22	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	DILs	dil	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	such	such	JJ	JJ	_	11	case	_	_
7	as	as	IN	IN	_	6	mwe	_	_
8	tumor	tumor	NN	NN	_	11	compound	_	_
9	necrosis	necrosis	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	2	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TNFalpha	tnfalpha	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cytotoxic	cytotoxic	JJ	JJ	_	18	amod	_	_
18	drug	drug	NN	NN	_	11	conj	_	_
19	doxorubicin	doxorubicin	NN	NN	_	18	dep	_	_
20	have	have	VBP	VBP	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	activate	activate	VB	VB	_	22	xcomp	_	_
25	a	a	DT	DT	_	33	det	_	_
26	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	kappaB	kappab	NN	NN	_	33	compound	_	_
29	(	(	-LRB-	-LRB-	_	33	punct	_	_
30	NFkappaB	nfkappab	NN	NN	_	33	compound	_	_
31	)	)	-RRB-	-RRB-	_	33	punct	_	_
32	-dependent	-dependent	JJ	JJ	_	33	amod	_	_
33	program	program	NN	NN	_	24	dobj	_	_
34	that	that	WDT	WDT	_	36	nsubj	_	_
35	may	may	MD	MD	_	36	aux	_	_
36	rescue	rescue	VB	VB	_	33	acl:relcl	_	_
37	cells	cell	NNS	NNS	_	36	dobj	_	_
38	from	from	IN	IN	_	40	case	_	_
39	apoptosis	apoptosis	NN	NN	_	40	compound	_	_
40	induction	induction	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	TRAIL	trail	NN	NN	_	18	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	TNF-related	tnf-related	JJ	JJ	_	9	amod	_	_
8	apoptosis-inducing	apoptosis-inducing	NN	NN	_	9	compound	_	_
9	ligand	ligand	NN	NN	_	5	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	5	punct	_	_
12	a	a	DT	DT	_	15	det	_	_
13	recently	recently	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	15	amod	_	_
15	DIL	dil	NN	NN	_	5	appos	_	_
16	,	,	,	,	_	5	punct	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	activates	activate	VBZ	VBZ	_	2	ccomp	_	_
19	NFkappaB	nfkappab	NN	NN	_	18	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	kinetic	kinetic	JJ	JJ	_	18	nmod	_	_
27	similar	similar	JJ	JJ	_	26	amod	_	_
28	to	to	TO	TO	_	29	case	_	_
29	TNFalpha	tnfalpha	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	NFkappaB	nfkappab	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	independent	independent	JJ	JJ	_	0	root	_	_
5	from	from	IN	IN	_	6	case	_	_
6	FADD	fadd	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	caspases	caspase	NNS	NNS	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	apoptosis	apoptosis	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	6	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	influence	influence	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NFkappaB	nfkappab	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	apoptosis	apoptosis	NN	NN	_	4	nmod	_	_
10	mediated	mediate	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	TRAIL	trail	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	CD95	cd95	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	TNFalpha	tnfalpha	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	or	or	CC	CC	_	12	cc	_	_
19	doxorubicin	doxorubicin	NN	NN	_	12	conj	_	_
20	,	,	,	,	_	2	punct	_	_
21	NFkappaB	nfkappab	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	inhibited	inhibit	VBN	VBN	_	2	parataxis	_	_
25	using	use	VBG	VBG	_	24	xcomp	_	_
26	the	the	DT	DT	_	28	det	_	_
27	proteasome	proteasome	NN	NN	_	28	compound	_	_
28	inhibitor	inhibitor	NN	NN	_	25	dobj	_	_
29	N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal	n-acetyl-l-leucinyl-l-leucinyl-l-norleucinal	NN	NN	_	28	dep	_	_
30	or	or	CC	CC	_	28	cc	_	_
31	transient	transient	JJ	JJ	_	32	amod	_	_
32	overexpression	overexpression	NN	NN	_	28	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	mutant	mutant	JJ	JJ	_	35	amod	_	_
35	IkappaBalpha	ikappabalpha	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Sensitivity	sensitivity	NN	NN	_	8	nsubjpass	_	_
2	for	for	IN	IN	_	3	case	_	_
3	induction	induction	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	apoptosis	apoptosis	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	markedly	markedly	RB	RB	_	8	advmod	_	_
8	increased	increase	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	treatments	treatment	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	apoptosis	apoptosis	NN	NN	_	14	nmod:npmod	_	_
14	sensitive	sensitive	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	29	advmod	_	_
2	,	,	,	,	_	29	punct	_	_
3	both	both	CC	CC	_	14	cc:preconj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	14	nmod	_	_
7	and	and	CC	CC	_	14	cc	_	_
8	in	in	IN	IN	_	11	case	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	14	conj	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	resistant	resistant	JJ	JJ	_	29	dep	_	_
15	towards	towards	IN	IN	_	16	case	_	_
16	induction	induction	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	DILs	dils	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	doxorubicin	doxorubicin	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	29	punct	_	_
24	antagonization	antagonization	NN	NN	_	29	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NFkappaB	nfkappab	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	nmod	_	_
28	partially	partially	RB	RB	_	29	advmod	_	_
29	restored	restore	VBD	VBD	_	0	root	_	_
30	apoptosis	apoptosis	NN	NN	_	31	compound	_	_
31	sensitivity	sensitivity	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	29	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	inhibition	inhibition	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NFkappaB	nfkappab	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	provide	provide	VB	VB	_	3	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	approach	approach	NN	NN	_	10	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	increase	increase	VB	VB	_	13	acl	_	_
16	apoptosis	apoptosis	NN	NN	_	17	compound	_	_
17	sensitivity	sensitivity	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	anticancer	anticancer	JJ	JJ	_	20	amod	_	_
20	treatment	treatment	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	HMG	hmg	NN	NN	_	2	compound	_	_
2	box	box	NN	NN	_	0	root	_	_
3	containing	contain	VBG	VBG	_	2	acl	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	mammalian	mammalian	JJ	JJ	_	8	amod	_	_
6	sex-determining	sex-determining	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	Sry	sry	NN	NN	_	2	nmod	_	_
9	has	have	VBZ	VBZ	_	10	aux	_	_
10	led	lead	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	discovery	discovery	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	large	large	JJ	JJ	_	17	amod	_	_
17	family	family	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	27	case	_	_
19	related	related	JJ	JJ	_	27	amod	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	'	'	``	``	_	23	punct	_	_
22	HMG	hmg	NN	NN	_	23	compound	_	_
23	box	box	NN	NN	_	19	dep	_	_
24	'	'	''	''	_	23	punct	_	_
25	)	)	-RRB-	-RRB-	_	23	punct	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	17	nmod	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	control	control	VBP	VBP	_	17	acl:relcl	_	_
30	developmental	developmental	JJ	JJ	_	31	amod	_	_
31	events	event	NNS	NNS	_	29	dobj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	yeast	yeast	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	C.	c.	FW	FW	_	36	compound	_	_
36	elegans	elegans	FW	FW	_	33	conj	_	_
37	,	,	,	,	_	33	punct	_	_
38	Drosophila	drosophila	FW	FW	_	33	conj	_	_
39	and	and	CC	CC	_	33	cc	_	_
40	vertebrates	vertebrate	NNS	NNS	_	33	conj	_	_
41	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
3	differentiation	differentiation	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	several	several	JJ	JJ	_	8	amod	_	_
6	HMG	hmg	NN	NN	_	8	compound	_	_
7	box	box	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	9	nsubj	_	_
9	play	play	VBP	VBP	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	decisive	decisive	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	9	punct	_	_

1	Sox-4	sox-4	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	important	important	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	8	case	_	_
5	very	very	RB	RB	_	6	advmod	_	_
6	early	early	JJ	JJ	_	8	amod	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	while	while	IN	IN	_	12	mark	_	_
11	TCF-1/LEF-1	tcf-1/lef-1	NN	NN	_	12	nsubj	_	_
12	play	play	VBP	VBP	_	3	advcl	_	_
13	a	a	DT	DT	_	15	det	_	_
14	crucial	crucial	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	early	early	JJ	JJ	_	19	amod	_	_
18	thymocyte	thymocyte	NN	NN	_	19	compound	_	_
19	development	development	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	TCF/LEF	tcf/lef	NN	NN	_	2	compound	_	_
2	proteins	protein	NNS	NNS	_	6	nsubjpass	_	_
3	have	have	VBP	VBP	_	6	aux	_	_
4	recently	recently	RB	RB	_	6	advmod	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	constitute	constitute	VB	VB	_	6	xcomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	downstream	downstream	JJ	JJ	_	11	amod	_	_
11	component	component	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	Wingless/Wnt	wingless/wnt	NN	NN	_	17	compound	_	_
15	signal	signal	NN	NN	_	17	compound	_	_
16	transduction	transduction	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	flies	fly	NNS	NNS	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	pathway	pathway	NN	NN	_	6	nsubj	_	_
6	controls	control	VBZ	VBZ	_	0	root	_	_
7	segment	segment	NN	NN	_	8	compound	_	_
8	polarity	polarity	NN	NN	_	6	dobj	_	_
9	;	;	:	:	_	6	punct	_	_
10	in	in	IN	IN	_	11	case	_	_
11	Xenopus	xenopus	FW	FW	_	13	nmod	_	_
12	it	it	PRP	PRP	_	13	nsubj	_	_
13	controls	control	VBZ	VBZ	_	6	parataxis	_	_
14	the	the	DT	DT	_	15	det	_	_
15	definition	definition	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	body	body	NN	NN	_	19	compound	_	_
19	axis	axis	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Deregulation	deregulation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	pathway	pathway	NN	NN	_	1	nmod	_	_
5	occurs	occur	VBZ	VBZ	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	several	several	JJ	JJ	_	9	amod	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	tumors	tumor	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	18	nsubj	_	_
2	insights	insight	VBZ	VBZ	_	1	dep	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	events	event	NNS	NNS	_	1	nmod	_	_
7	that	that	WDT	WDT	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	6	acl:relcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	TCF/LEF	tcf/lef	NN	NN	_	12	compound	_	_
12	function	function	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	organisms	organism	NNS	NNS	_	12	nmod	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	eventually	eventually	RB	RB	_	18	advmod	_	_
18	lead	lead	VB	VB	_	0	root	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	understanding	understanding	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	function	function	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	these	these	DT	DT	_	29	det	_	_
27	HMG	hmg	NN	NN	_	29	compound	_	_
28	box	box	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	24	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	lymphoid	lymphoid	JJ	JJ	_	32	amod	_	_
32	development	development	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	18	punct	_	_

1	Loss-	loss-	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	gain-of-function	gain-of-function	NN	NN	_	1	conj	_	_
4	mutations	mutation	NNS	NNS	_	1	dep	_	_
5	reveal	reveal	VBP	VBP	_	0	root	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	BSAP	bsap	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Pax-5	pax-5	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	at	at	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	start	start	NN	NN	_	8	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	end	end	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	differentiation	differentiation	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Pax-5	pax-5	NN	NN	_	2	nsubj	_	_
2	codes	code	VBZ	VBZ	_	0	root	_	_
3	for	for	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	2	nmod	_	_
7	BSAP	bsap	NN	NN	_	6	dep	_	_
8	which	which	WDT	WDT	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	6	acl:relcl	_	_
11	throughout	throughout	IN	IN	_	14	case	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	development	development	NN	NN	_	10	nmod	_	_
15	except	except	NN	NN	_	20	dep	_	_
16	in	in	IN	IN	_	20	case	_	_
17	terminally	terminally	RB	RB	_	20	advmod	_	_
18	differentiated	differentiate	VBN	VBN	_	20	amod	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	10	advcl	_	_
21	.	.	.	.	_	2	punct	_	_

1	Gene	gene	NN	NN	_	3	compound	_	_
2	targeting	targeting	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	7	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mouse	mouse	NN	NN	_	3	nmod	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	differential	differential	JJ	JJ	_	10	amod	_	_
10	dependency	dependency	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	fetal	fetal	JJ	JJ	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	adult	adult	JJ	JJ	_	12	conj	_	_
15	B-lymphopoiesis	b-lymphopoiesis	NN	NN	_	12	dep	_	_
16	on	on	IN	IN	_	19	case	_	_
17	this	this	DT	DT	_	19	det	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	BSAP	bsap	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	required	require	VBN	VBN	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	B-lineage	b-lineage	NN	NN	_	6	compound	_	_
6	commitment	commitment	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	fetal	fetal	JJ	JJ	_	10	amod	_	_
10	liver	liver	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	for	for	IN	IN	_	13	case	_	_
13	progression	progression	NN	NN	_	6	conj	_	_
14	beyond	beyond	IN	IN	_	19	case	_	_
15	an	a	DT	DT	_	19	det	_	_
16	early	early	JJ	JJ	_	19	amod	_	_
17	pro-B	pro-b	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	stage	stage	NN	NN	_	13	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	adult	adult	JJ	JJ	_	23	amod	_	_
22	bone	bone	NN	NN	_	23	compound	_	_
23	marrow	marrow	NN	NN	_	13	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	characterization	characterization	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	Pax-5-deficient	pax-5-deficient	JJ	JJ	_	6	amod	_	_
5	pro-B	pro-b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	BSAP	bsap	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	regulation	regulation	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	dep	_	_
18	CD19	cd19	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	mb-1	mb-1	NN	NN	_	18	conj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	Ig	ig	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	N-myc	n-myc	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	18	conj	_	_
28	as	as	RB	RB	_	15	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	developmental	developmental	JJ	JJ	_	34	amod	_	_
34	pathway	pathway	NN	NN	_	15	conj	_	_
35	controlling	control	VBG	VBG	_	34	acl	_	_
36	VH-to-DHJH	vh-to-dhjh	JJ	JJ	_	37	amod	_	_
37	recombination	recombination	NN	NN	_	35	dobj	_	_
38	at	at	IN	IN	_	45	case	_	_
39	the	the	DT	DT	_	45	det	_	_
40	immunoglobulin	immunoglobulin	NN	NN	_	45	compound	_	_
41	heavy-chain	heavy-chain	JJ	JJ	_	45	amod	_	_
42	(	(	-LRB-	-LRB-	_	45	punct	_	_
43	IgH	igh	NN	NN	_	45	compound	_	_
44	)	)	-RRB-	-RRB-	_	45	punct	_	_
45	locus	locus	NN	NN	_	37	nmod	_	_
46	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	PAX-5	pax-5	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	recently	recently	RB	RB	_	7	advmod	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	participate	participate	VB	VB	_	7	xcomp	_	_
10	together	together	RB	RB	_	14	advmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IgH	igh	NN	NN	_	14	compound	_	_
14	locus	locus	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	chromosomal	chromosomal	JJ	JJ	_	18	amod	_	_
18	translocation	translocation	NN	NN	_	9	nmod	_	_
19	t(9;14)(p13;q32)	t(9;14)(p13;q32)	NN	NN	_	18	dep	_	_
20	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	translocation	translocation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	characteristic	characteristic	JJ	JJ	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	small	small	JJ	JJ	_	8	amod	_	_
8	subset	subset	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	non-Hodgkin	non-hodgkin	JJ	JJ	_	11	amod	_	_
11	lymphomas	lymphoma	NNS	NNS	_	8	nmod	_	_
12	exhibiting	exhibit	VBG	VBG	_	8	acl	_	_
13	plasmacytoid	plasmacytoid	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	translocated	translocated	JJ	JJ	_	4	amod	_	_
3	PAX-5	pax-5	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	deregulated	deregulate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	insertion	insertion	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	IgH	igh	NN	NN	_	13	compound	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	elements	element	NNS	NNS	_	9	nmod	_	_
14	into	into	IN	IN	_	17	case	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	5'	5'	JJ	JJ	_	17	amod	_	_
17	region	region	NN	NN	_	9	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	contribute	contribute	VB	VB	_	6	ccomp	_	_
22	to	to	TO	TO	_	23	case	_	_
23	tumorigenesis	tumorigenesis	NN	NN	_	21	nmod	_	_
24	by	by	IN	IN	_	25	mark	_	_
25	interfering	interfere	VBG	VBG	_	21	advcl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	shut-down	shut-down	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	PAX-5	pax-5	NN	NN	_	31	compound	_	_
31	transcription	transcription	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	thus	thus	RB	RB	_	36	advmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	completion	completion	NN	NN	_	28	conj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	plasma	plasma	NN	NN	_	39	compound	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	differentiation	differentiation	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E-proteins	e-protein	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	B-	b-	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	T-lymphocyte	t-lymphocyte	NN	NN	_	6	conj	_	_
9	development	development	NN	NN	_	6	dep	_	_
10	.	.	.	.	_	2	punct	_	_

1	Department	department	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
4	from	from	IN	IN	_	7	case	_	_
5	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
6	stem	stem	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	controlled	control	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	part	part	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activity	activity	NN	NN	_	9	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	one	one	CD	CD	_	5	nummod	_	_
5	class	class	NN	NN	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	helix-loop-helix	helix-loop-helix	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	termed	term	VBN	VBN	_	5	acl	_	_
11	E-proteins	e-protein	NNS	NNS	_	10	xcomp	_	_
12	,	,	,	,	_	5	punct	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	implicated	implicate	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	regulation	regulation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	during	during	IN	IN	_	24	case	_	_
23	B-cell	b-cell	NN	NN	_	24	compound	_	_
24	development	development	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gene-targeted	gene-targeted	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	7	aux	_	_
7	allowed	allow	VBN	VBN	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	direct	direct	JJ	JJ	_	10	amod	_	_
10	assessment	assessment	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	roles	role	NNS	NNS	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	several	several	JJ	JJ	_	19	amod	_	_
17	E-protein	e-protein	NN	NN	_	19	compound	_	_
18	family	family	NN	NN	_	19	compound	_	_
19	members	member	NNS	NNS	_	14	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	hematopoiesis	hematopoiesis	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	describe	describe	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	defects	defect	NNS	NNS	_	5	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	B-	b-	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	T-lymphocyte	t-lymphocyte	NN	NN	_	9	conj	_	_
12	development	development	NN	NN	_	9	dep	_	_
13	in	in	IN	IN	_	14	case	_	_
14	mice	mouse	NNS	NNS	_	5	nmod	_	_
15	carrying	carry	VBG	VBG	_	14	acl	_	_
16	targeted	target	VBN	VBN	_	17	amod	_	_
17	mutations	mutation	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	E-protein	e-protein	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	5	cc	_	_
23	discuss	discuss	VBP	VBP	_	5	conj	_	_
24	our	we	PRP$	PRP$	_	26	nmod:poss	_	_
25	current	current	JJ	JJ	_	26	amod	_	_
26	understanding	understanding	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	role	role	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	these	these	DT	DT	_	32	det	_	_
32	proteins	protein	NNS	NNS	_	29	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	lymphoid	lymphoid	JJ	JJ	_	35	amod	_	_
35	development	development	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Oxidative	oxidative	JJ	JJ	_	2	amod	_	_
2	stress	stress	NN	NN	_	3	nsubj	_	_
3	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	activities	activity	NNS	NNS	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	stimulated	stimulate	VBN	VBN	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	16	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	oxidative	oxidative	JJ	JJ	_	4	amod	_	_
4	stress	stress	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	stimulation-dependent	stimulation-dependent	JJ	JJ	_	8	amod	_	_
7	signal	signal	NN	NN	_	8	compound	_	_
8	transduction	transduction	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	leading	lead	VBG	VBG	_	8	acl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	studied	study	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Purified	purify	VBN	VBN	_	6	amod	_	_
2	quiescent	quiescent	JJ	JJ	_	6	amod	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	blood	blood	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	subjected	subject	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	8	nmod	_	_
10	:	:	:	:	_	8	punct	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	i	i	LS	LS	_	15	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	acute	acute	JJ	JJ	_	15	amod	_	_
15	exposure	exposure	NN	NN	_	8	dep	_	_
16	to	to	TO	TO	_	18	case	_	_
17	hydrogen	hydrogen	NN	NN	_	18	compound	_	_
18	peroxide	peroxide	NN	NN	_	15	nmod	_	_
19	;	;	:	:	_	15	punct	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ii	ii	LS	LS	_	24	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	chronic	chronic	JJ	JJ	_	24	amod	_	_
24	exposure	exposure	NN	NN	_	15	conj	_	_
25	to	to	TO	TO	_	27	case	_	_
26	hydrogen	hydrogen	NN	NN	_	27	compound	_	_
27	peroxide	peroxide	NN	NN	_	24	nmod	_	_
28	;	;	:	:	_	15	punct	_	_
29	and	and	CC	CC	_	15	cc	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	iii	iii	LS	LS	_	34	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	acute	acute	JJ	JJ	_	34	amod	_	_
34	exposure	exposure	NN	NN	_	15	conj	_	_
35	to	to	TO	TO	_	37	case	_	_
36	ionizing	ionize	VBG	VBG	_	37	amod	_	_
37	radiation	radiation	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	then	then	RB	RB	_	5	advmod	_	_
5	stimulated	stimulate	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	6	6	CD	CD	_	8	nummod	_	_
8	h	h	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	DNA-binding	dna-binding	JJ	JJ	_	2	amod	_	_
2	activities	activity	NNS	NNS	_	24	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	determined	determine	VBN	VBN	_	2	dep	_	_
5	by	by	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	10	amod	_	_
8	mobility	mobility	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	4	nmod	_	_
11	)	)	-RRB-	-RRB-	_	4	punct	_	_
12	of	of	IN	IN	_	15	case	_	_
13	three	three	CD	CD	_	15	nummod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	2	nmod	_	_
16	:	:	:	:	_	15	punct	_	_
17	NFkappaB	nfkappab	NN	NN	_	15	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	AP-1	ap-1	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	NFAT	nfat	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	2	punct	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	abolished	abolish	VBN	VBN	_	0	root	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
28	by	by	IN	IN	_	31	case	_	_
29	all	all	DT	DT	_	31	det	_	_
30	three	three	CD	CD	_	31	nummod	_	_
31	modes	mode	NNS	NNS	_	24	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	oxidative	oxidative	JJ	JJ	_	34	amod	_	_
34	stress	stress	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	3	nsubj	_	_
3	exhibited	exhibit	VBD	VBD	_	0	root	_	_
4	lipid	lipid	NN	NN	_	5	compound	_	_
5	peroxidation	peroxidation	NN	NN	_	3	dobj	_	_
6	only	only	RB	RB	_	8	advmod	_	_
7	upon	upon	IN	IN	_	8	case	_	_
8	exposure	exposure	NN	NN	_	3	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	lowest	lowest	JJS	JJS	_	12	amod	_	_
12	level	level	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	hydrogen	hydrogen	NN	NN	_	15	compound	_	_
15	peroxide	peroxide	NN	NN	_	12	nmod	_	_
16	used	use	VBN	VBN	_	15	acl	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	20	20	CD	CD	_	19	nummod	_	_
19	microM	microm	NN	NN	_	12	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	modes	mode	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	oxidative	oxidative	JJ	JJ	_	6	amod	_	_
6	stress	stress	NN	NN	_	3	nmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	catalase	catalase	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	only	only	RB	RB	_	3	advmod	_	_
3	exception	exception	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	hydrogen	hydrogen	NN	NN	_	6	compound	_	_
6	peroxide	peroxide	NN	NN	_	0	root	_	_
7	at	at	IN	IN	_	9	case	_	_
8	20	20	CD	CD	_	9	nummod	_	_
9	microM	microm	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	which	which	WDT	WDT	_	14	nsubj	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	induce	induce	VB	VB	_	6	acl:relcl	_	_
15	catalase	catalase	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	:	:	:	:	_	16	punct	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	i	i	LS	LS	_	16	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	suppression	suppression	NN	NN	_	16	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	specific	specific	JJ	JJ	_	13	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	functions	function	NNS	NNS	_	8	nmod	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	potentially	potentially	RB	RB	_	16	advmod	_	_
16	serve	serve	VB	VB	_	2	ccomp	_	_
17	as	as	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	marker	marker	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	exposure	exposure	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	oxidative	oxidative	JJ	JJ	_	24	amod	_	_
24	stress	stress	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	effects	effect	NNS	NNS	_	21	conj	_	_
28	on	on	IN	IN	_	30	case	_	_
29	human	human	JJ	JJ	_	30	amod	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	27	nmod	_	_
31	;	;	:	:	_	16	punct	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	ii	ii	LS	LS	_	39	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	lipid	lipid	NN	NN	_	36	compound	_	_
36	peroxidation	peroxidation	NN	NN	_	39	nsubj	_	_
37	is	be	VBZ	VBZ	_	39	cop	_	_
38	only	only	RB	RB	_	39	advmod	_	_
39	detectable	detectable	JJ	JJ	_	16	parataxis	_	_
40	in	in	IN	IN	_	42	case	_	_
41	human	human	JJ	JJ	_	42	amod	_	_
42	lymphocytes	lymphocyte	NNS	NNS	_	39	nmod	_	_
43	upon	upon	IN	IN	_	44	case	_	_
44	exposure	exposure	NN	NN	_	39	nmod	_	_
45	to	to	TO	TO	_	48	case	_	_
46	weak	weak	JJ	JJ	_	47	amod	_	_
47	oxidative	oxidative	JJ	JJ	_	48	amod	_	_
48	stress	stress	NN	NN	_	44	nmod	_	_
49	which	which	WDT	WDT	_	52	nsubj	_	_
50	does	do	VBZ	VBZ	_	52	aux	_	_
51	not	not	RB	RB	_	52	neg	_	_
52	induce	induce	VB	VB	_	44	acl:relcl	_	_
53	catalase	catalase	NN	NN	_	54	compound	_	_
54	activity	activity	NN	NN	_	52	dobj	_	_
55	;	;	:	:	_	16	punct	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	iii	iii	LS	LS	_	67	dep	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	therefore	therefore	RB	RB	_	67	advmod	_	_
60	,	,	,	,	_	67	punct	_	_
61	transcription	transcription	NN	NN	_	62	compound	_	_
62	factor	factor	NN	NN	_	64	compound	_	_
63	DNA-binding	dna-binding	JJ	JJ	_	64	amod	_	_
64	activities	activity	NNS	NNS	_	67	nsubj	_	_
65	are	be	VBP	VBP	_	67	cop	_	_
66	more	more	RBR	RBR	_	67	advmod	_	_
67	sensitive	sensitive	JJ	JJ	_	16	parataxis	_	_
68	to	to	TO	TO	_	70	case	_	_
69	oxidative	oxidative	JJ	JJ	_	70	amod	_	_
70	stress	stress	NN	NN	_	67	nmod	_	_
71	than	than	IN	IN	_	73	mark	_	_
72	lipid	lipid	NN	NN	_	73	compound	_	_
73	peroxidation	peroxidation	NN	NN	_	67	ccomp	_	_
74	.	.	.	.	_	2	punct	_	_

1	Ro	ro	NN	NN	_	3	nsubj	_	_
2	09-2210	09-2210	CD	CD	_	1	nummod	_	_
3	exhibits	exhibit	VBZ	VBZ	_	0	root	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	anti-proliferative	anti-proliferative	JJ	JJ	_	4	dep	_	_
6	effects	effect	NNS	NNS	_	3	dobj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	activated	activate	VBN	VBN	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	by	by	IN	IN	_	13	mark	_	_
12	selectively	selectively	RB	RB	_	13	advmod	_	_
13	blocking	block	VBG	VBG	_	3	advcl	_	_
14	MKK	mkk	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	12	advcl	_	_
3	high	high	JJ	JJ	_	5	amod	_	_
4	throughput	throughput	NN	NN	_	5	compound	_	_
5	screening	screening	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	microbial	microbial	JJ	JJ	_	8	amod	_	_
8	broths	broth	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	we	we	PRP	PRP	_	12	nsubj	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	identified	identify	VBN	VBN	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	compound	compound	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	designated	designate	VBN	VBN	_	14	acl	_	_
17	Ro	ro	NN	NN	_	16	xcomp	_	_
18	09-2210	09-2210	CD	CD	_	17	nummod	_	_
19	,	,	,	,	_	14	punct	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	able	able	JJ	JJ	_	14	acl:relcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	block	block	VB	VB	_	22	xcomp	_	_
25	anti-CD3	anti-cd3	JJ	JJ	_	26	nmod:npmod	_	_
26	induced	induced	JJ	JJ	_	31	amod	_	_
27	peripheral	peripheral	JJ	JJ	_	31	amod	_	_
28	blood	blood	NN	NN	_	31	compound	_	_
29	T	t	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	24	dobj	_	_
32	with	with	IN	IN	_	34	case	_	_
33	an	a	DT	DT	_	34	det	_	_
34	IC50	ic50	NN	NN	_	24	nmod	_	_
35	=	=	JJ	JJ	_	34	amod	_	_
36	40	40	CD	CD	_	37	nummod	_	_
37	nM	nm	NN	NN	_	35	dep	_	_
38	.	.	.	.	_	12	punct	_	_

1	Ro	ro	NN	NN	_	5	nsubj	_	_
2	09-2210	09-2210	CD	CD	_	1	nummod	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	block	block	VB	VB	_	5	xcomp	_	_
8	antigen-induced	antigen-induced	JJ	JJ	_	10	amod	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	7	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	an	a	DT	DT	_	13	det	_	_
13	IC50	ic50	NN	NN	_	7	nmod	_	_
14	=	=	JJ	JJ	_	13	amod	_	_
15	30	30	CD	CD	_	16	nummod	_	_
16	nM	nm	NN	NN	_	14	dep	_	_
17	,	,	,	,	_	5	punct	_	_
18	but	but	CC	CC	_	5	cc	_	_
19	was	be	VBD	VBD	_	22	cop	_	_
20	considerably	considerably	RB	RB	_	21	advmod	_	_
21	less	less	RBR	RBR	_	22	advmod	_	_
22	potent	potent	JJ	JJ	_	5	conj	_	_
23	at	at	IN	IN	_	24	mark	_	_
24	blocking	block	VBG	VBG	_	22	advcl	_	_
25	Ca2+	ca2+	NN	NN	_	26	compound	_	_
26	flux	flux	NN	NN	_	24	dobj	_	_
27	stimulated	stimulate	VBN	VBN	_	26	acl	_	_
28	by	by	IN	IN	_	30	case	_	_
29	anti-CD3	anti-cd3	JJ	JJ	_	30	compound	_	_
30	treatment	treatment	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	action	action	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Ro	ro	NN	NN	_	6	nmod	_	_
9	09-2210	09-2210	CD	CD	_	8	nummod	_	_
10	,	,	,	,	_	2	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	set	set	VBD	VBD	_	2	parataxis	_	_
13	up	up	IN	IN	_	12	compound:prt	_	_
14	a	a	DT	DT	_	17	det	_	_
15	transient	transient	JJ	JJ	_	17	amod	_	_
16	expression	expression	NN	NN	_	17	compound	_	_
17	system	system	NN	NN	_	12	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	Jurkat	jurkat	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	12	nmod	_	_
22	using	use	VBG	VBG	_	12	xcomp	_	_
23	a	a	DT	DT	_	24	det	_	_
24	variety	variety	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	reporter	reporter	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	constructs	construct	NNS	NNS	_	24	nmod	_	_
29	and	and	CC	CC	_	12	cc	_	_
30	showed	show	VBD	VBD	_	12	conj	_	_
31	effective	effective	JJ	JJ	_	32	amod	_	_
32	inhibition	inhibition	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	phorbol	phorbol	NN	NN	_	35	nmod:npmod	_	_
35	ester/ionomycin-induced	ester/ionomycin-induced	JJ	JJ	_	37	amod	_	_
36	NF-AT	nf-at	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	32	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	anti-CD3	anti-cd3	NN	NN	_	41	amod	_	_
40	induced	induce	VBD	VBD	_	39	dep	_	_
41	NF-AT	nf-at	NN	NN	_	37	conj	_	_
42	with	with	IN	IN	_	43	case	_	_
43	IC50	ic50	NN	NN	_	32	nmod	_	_
44	=	=	JJ	JJ	_	43	amod	_	_
45	7.7	7.7	CD	CD	_	44	dep	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	10	10	CD	CD	_	45	conj	_	_
48	nM	nm	NN	NN	_	45	dep	_	_
49	,	,	,	,	_	32	punct	_	_
50	respectively	respectively	RB	RB	_	32	advmod	_	_
51	.	.	.	.	_	2	punct	_	_

1	Ro	ro	NN	NN	_	5	nsubj	_	_
2	09-2210	09-2210	CD	CD	_	1	nummod	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	inhibit	inhibit	VB	VB	_	5	xcomp	_	_
8	phorbol	phorbol	NN	NN	_	9	nmod:npmod	_	_
9	ester/ionomycin-induced	ester/ionomycin-induced	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	AP1	ap1	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	IC50	ic50	NN	NN	_	7	nmod	_	_
15	=	=	JJ	JJ	_	14	amod	_	_
16	&lt;	&lt;	JJR	JJR	_	15	dep	_	_
17	10	10	CD	CD	_	18	nummod	_	_
18	nM	nm	NN	NN	_	15	dep	_	_
19	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	Ro	ro	NN	NN	_	8	nsubj	_	_
6	09-2210	09-2210	CD	CD	_	5	nummod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	unable	unable	JJ	JJ	_	3	ccomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	inhibit	inhibit	VB	VB	_	8	xcomp	_	_
11	c-jun	c-jun	NN	NN	_	12	nmod:npmod	_	_
12	induced	induced	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	AP1-dependent	ap1-dependent	JJ	JJ	_	17	amod	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	constructs	construct	NNS	NNS	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	IC50	ic50	NN	NN	_	10	dep	_	_
20	&gt;	&gt;	JJR	JJR	_	19	amod	_	_
21	500	500	CD	CD	_	22	nummod	_	_
22	nM	nm	NN	NN	_	20	dep	_	_
23	)	)	-RRB-	-RRB-	_	19	punct	_	_
24	,	,	,	,	_	8	punct	_	_
25	but	but	CC	CC	_	8	cc	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	able	able	JJ	JJ	_	8	conj	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	potently	potently	RB	RB	_	30	advmod	_	_
30	inhibit	inhibit	VB	VB	_	27	xcomp	_	_
31	ras-induced	ras-induced	JJ	JJ	_	33	amod	_	_
32	AP1	ap1	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	30	dobj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	IC50	ic50	NN	NN	_	30	dep	_	_
36	=	=	JJ	JJ	_	35	amod	_	_
37	20	20	CD	CD	_	38	nummod	_	_
38	nM	nm	NN	NN	_	36	dep	_	_
39	)	)	-RRB-	-RRB-	_	35	punct	_	_
40	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggested	suggest	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	Ro	ro	NN	NN	_	7	nsubj	_	_
5	09-2210	09-2210	CD	CD	_	4	nummod	_	_
6	was	be	VBD	VBD	_	7	aux	_	_
7	inhibiting	inhibit	VBG	VBG	_	2	ccomp	_	_
8	an	a	DT	DT	_	9	det	_	_
9	activator	activator	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	AP-1	ap-1	NN	NN	_	9	nmod	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	was	be	VBD	VBD	_	11	acl:relcl	_	_
14	upstream	upstream	JJ	JJ	_	17	advmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	c-jun	c-jun	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	13	advmod	_	_
18	downstream	downstream	RB	RB	_	17	advmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	ras	ras	NN	NN	_	21	compound	_	_
21	signaling	signaling	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	further	further	RB	RB	_	2	advmod	_	_
4	,	,	,	,	_	2	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	then	then	RB	RB	_	7	advmod	_	_
7	purified	purify	VBN	VBN	_	2	parataxis	_	_
8	a	a	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	kinases	kinase	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	including	include	VBG	VBG	_	15	case	_	_
15	PKC	pkc	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	PhK	phk	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	ZAP-70	zap-70	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	ERK	erk	NN	NN	_	15	conj	_	_
22	,	,	,	,	_	15	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	MEK	mek	NN	NN	_	15	conj	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	a	a	NN	NN	_	24	appos	_	_
28	MKK	mkk	NN	NN	_	27	dep	_	_
29	)	)	-RRB-	-RRB-	_	27	punct	_	_
30	,	,	,	,	_	7	punct	_	_
31	and	and	CC	CC	_	7	cc	_	_
32	showed	show	VBD	VBD	_	7	conj	_	_
33	that	that	IN	IN	_	39	mark	_	_
34	Ro	ro	NN	NN	_	39	nsubj	_	_
35	09-2210	09-2210	CD	CD	_	34	nummod	_	_
36	was	be	VBD	VBD	_	39	cop	_	_
37	a	a	DT	DT	_	39	det	_	_
38	selective	selective	JJ	JJ	_	39	amod	_	_
39	inhibitor	inhibitor	NN	NN	_	32	ccomp	_	_
40	of	of	IN	IN	_	41	case	_	_
41	MEK1	mek1	NN	NN	_	39	nmod	_	_
42	in	in	FW	FW	_	43	compound	_	_
43	vitro	vitro	FW	FW	_	39	advmod	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	IC50	ic50	NN	NN	_	39	dep	_	_
46	=	=	JJ	JJ	_	45	amod	_	_
47	59	59	CD	CD	_	48	nummod	_	_
48	nM	nm	NN	NN	_	46	dep	_	_
49	)	)	-RRB-	-RRB-	_	45	punct	_	_
50	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	GATA-1	gata-1	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	5	case	_	_
5	proliferation	proliferation	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	differentiation	differentiation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	definitive	definitive	JJ	JJ	_	10	amod	_	_
10	erythroid	erythroid	JJ	JJ	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	megakaryocytic	megakaryocytic	JJ	JJ	_	10	conj	_	_
13	cells	cell	NNS	NNS	_	10	dep	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	5	advmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	elucidate	elucidate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	contributions	contribution	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	GATA-1	gata-1	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	definitive	definitive	JJ	JJ	_	9	amod	_	_
9	hematopoiesis	hematopoiesis	NN	NN	_	4	nmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	we	we	PRP	PRP	_	15	nsubj	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	examined	examine	VBN	VBN	_	2	parataxis	_	_
16	adult	adult	JJ	JJ	_	17	amod	_	_
17	mice	mouse	NNS	NNS	_	15	dobj	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	rendered	render	VBN	VBN	_	17	acl:relcl	_	_
21	genetically	genetically	RB	RB	_	22	advmod	_	_
22	defective	defective	JJ	JJ	_	20	xcomp	_	_
23	in	in	IN	IN	_	25	case	_	_
24	GATA-1	gata-1	NN	NN	_	25	compound	_	_
25	synthesis	synthesis	NN	NN	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	Takahashi	Takahashi	NNP	NNP	_	2	dep	_	_
28	et	et	FW	FW	_	27	compound	_	_
29	al	al	FW	FW	_	27	dep	_	_
30	,	,	,	,	_	27	punct	_	_
31	J	J	NNP	NNP	_	33	compound	_	_
32	Biol	Biol	NNP	NNP	_	33	compound	_	_
33	Chem	Chem	NNP	NNP	_	27	appos	_	_
34	272	272	CD	CD	_	33	nummod	_	_
35	:	:	:	:	_	27	punct	_	_
36	12611	12611	CD	CD	_	27	dep	_	_
37	,	,	,	,	_	27	punct	_	_
38	1997	1997	CD	CD	_	27	amod	_	_
39	)	)	-RRB-	-RRB-	_	27	punct	_	_
40	.	.	.	.	_	2	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	GATA-1	gata-1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	located	located	JJ	JJ	_	23	advcl	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	X	x	NN	NN	_	10	compound	_	_
10	chromosome	chromosome	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	15	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	randomly	randomly	RB	RB	_	15	advmod	_	_
15	inactivated	inactivate	VBN	VBN	_	10	acl:relcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	every	every	JJ	JJ	_	18	amod	_	_
18	cell	cell	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	heterozygous	heterozygous	JJ	JJ	_	21	amod	_	_
21	females	female	NNS	NNS	_	23	nsubj	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	bear	bear	VB	VB	_	0	root	_	_
24	either	either	CC	CC	_	27	cc:preconj	_	_
25	an	a	DT	DT	_	27	dep	_	_
26	active	active	JJ	JJ	_	27	amod	_	_
27	wild-type	wild-type	JJ	JJ	_	23	dobj	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	mutant	mutant	JJ	JJ	_	27	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	referred	refer	VBN	VBN	_	29	dep	_	_
32	to	to	TO	TO	_	31	nmod	_	_
33	as	as	IN	IN	_	34	case	_	_
34	GATA-1.05	gata-1.05	NN	NN	_	31	nmod	_	_
35	)	)	-RRB-	-RRB-	_	31	punct	_	_
36	GATA-1	gata-1	NN	NN	_	37	compound	_	_
37	allele	allele	NN	NN	_	27	dep	_	_
38	,	,	,	,	_	23	punct	_	_
39	consequently	consequently	RB	RB	_	40	advmod	_	_
40	leading	lead	VBG	VBG	_	23	advcl	_	_
41	to	to	TO	TO	_	44	case	_	_
42	variable	variable	JJ	JJ	_	44	amod	_	_
43	anemic	anemic	JJ	JJ	_	42	dep	_	_
44	severity	severity	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	23	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	heterozygous	heterozygous	JJ	JJ	_	4	amod	_	_
3	mutant	mutant	JJ	JJ	_	4	amod	_	_
4	mice	mouse	NNS	NNS	_	6	nsubj	_	_
5	usually	usually	RB	RB	_	6	advmod	_	_
6	developed	develop	VBN	VBN	_	0	root	_	_
7	normally	normally	RB	RB	_	6	advmod	_	_
8	,	,	,	,	_	6	punct	_	_
9	but	but	CC	CC	_	6	cc	_	_
10	they	they	PRP	PRP	_	11	nsubj	_	_
11	began	begin	VBD	VBD	_	6	conj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	die	die	VB	VB	_	11	xcomp	_	_
14	after	after	IN	IN	_	16	case	_	_
15	5	5	CD	CD	_	16	nummod	_	_
16	months	month	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	affected	affect	VBN	VBN	_	3	amod	_	_
3	animals	animal	NNS	NNS	_	4	nsubj	_	_
4	displayed	display	VBD	VBD	_	0	root	_	_
5	marked	marked	JJ	JJ	_	6	amod	_	_
6	splenomegaly	splenomegaly	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	anemia	anemia	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	thrombocytopenia	thrombocytopenia	NN	NN	_	6	conj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Proerythroblasts	proerythroblast	NNS	NNS	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	megakaryocytes	megakaryocyte	NNS	NNS	_	1	conj	_	_
4	massively	massively	RB	RB	_	5	advmod	_	_
5	accumulated	accumulate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	spleens	spleen	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	heterozygotes	heterozygote	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	showed	show	VBD	VBD	_	5	conj	_	_
16	that	that	IN	IN	_	33	mark	_	_
17	the	the	DT	DT	_	20	det	_	_
18	neomycin	neomycin	NN	NN	_	20	compound	_	_
19	resistance	resistance	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	33	nsubjpass	_	_
21	(	(	-LRB-	-LRB-	_	27	punct	_	_
22	which	which	WDT	WDT	_	27	nsubj	_	_
23	is	be	VBZ	VBZ	_	27	cop	_	_
24	the	the	DT	DT	_	27	det	_	_
25	positive	positive	JJ	JJ	_	27	amod	_	_
26	selection	selection	NN	NN	_	27	compound	_	_
27	marker	marker	NN	NN	_	20	dep	_	_
28	in	in	IN	IN	_	30	case	_	_
29	ES	es	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	)	)	-RRB-	-RRB-	_	27	punct	_	_
32	was	be	VBD	VBD	_	33	auxpass	_	_
33	expressed	express	VBN	VBN	_	15	ccomp	_	_
34	profusely	profusely	RB	RB	_	33	advmod	_	_
35	in	in	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	abnormally	abnormally	RB	RB	_	38	advmod	_	_
38	abundant	abundant	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	33	nmod	_	_
40	generated	generate	VBN	VBN	_	39	acl	_	_
41	in	in	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	GATA-1.05	gata-1.05	NN	NN	_	45	compound	_	_
44	mutant	mutant	JJ	JJ	_	45	amod	_	_
45	females	female	NNS	NNS	_	40	nmod	_	_
46	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	observed	observe	VBD	VBD	_	0	root	_	_
4	hematopoiesis	hematopoiesis	NN	NN	_	3	dobj	_	_
5	outside	outside	NN	NN	_	9	dep	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	bone	bone	NN	NN	_	9	compound	_	_
9	marrow	marrow	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	affected	affect	VBN	VBN	_	14	amod	_	_
13	mutant	mutant	JJ	JJ	_	14	amod	_	_
14	mice	mouse	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	small	small	JJ	JJ	_	7	amod	_	_
7	number	number	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	GATA-1.05	gata-1.05	NN	NN	_	13	compound	_	_
10	mutant	mutant	JJ	JJ	_	13	amod	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
12	progenitor	progenitor	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	begin	begin	VBP	VBP	_	3	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	proliferate	proliferate	VB	VB	_	14	xcomp	_	_
17	vigorously	vigorously	RB	RB	_	16	advmod	_	_
18	during	during	IN	IN	_	20	case	_	_
19	early	early	JJ	JJ	_	20	amod	_	_
20	adulthood	adulthood	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	but	but	CC	CC	_	14	cc	_	_
23	because	because	IN	IN	_	27	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	27	nsubj	_	_
26	are	be	VBP	VBP	_	27	cop	_	_
27	unable	unable	JJ	JJ	_	33	advcl	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	terminally	terminally	RB	RB	_	30	advmod	_	_
30	differentiate	differentiate	VB	VB	_	27	xcomp	_	_
31	,	,	,	,	_	33	punct	_	_
32	this	this	DT	DT	_	33	nsubj	_	_
33	leads	lead	VBZ	VBZ	_	14	conj	_	_
34	to	to	TO	TO	_	36	case	_	_
35	progenitor	progenitor	NN	NN	_	36	compound	_	_
36	proliferation	proliferation	NN	NN	_	33	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	spleen	spleen	NN	NN	_	36	nmod	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	consequently	consequently	RB	RB	_	42	advmod	_	_
42	death	death	NN	NN	_	36	conj	_	_
43	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	GATA-1	gata-1	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	0	root	_	_
5	important	important	JJ	JJ	_	8	amod	_	_
6	in	in	FW	FW	_	5	dep	_	_
7	vivo	vivo	FW	FW	_	6	dep	_	_
8	roles	role	NNS	NNS	_	4	dobj	_	_
9	for	for	IN	IN	_	10	mark	_	_
10	directing	direct	VBG	VBG	_	4	advcl	_	_
11	definitive	definitive	JJ	JJ	_	13	amod	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
13	progenitors	progenitor	NNS	NNS	_	10	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	differentiate	differentiate	VB	VB	_	10	xcomp	_	_
16	along	along	IN	IN	_	19	case	_	_
17	both	both	CC	CC	_	19	cc:preconj	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	erythroid	erythroid	JJ	JJ	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	megakaryocytic	megakaryocytic	JJ	JJ	_	19	conj	_	_
22	pathways	pathway	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	GATA-1	gata-1	NN	NN	_	5	compound	_	_
3	heterozygous	heterozygous	JJ	JJ	_	5	amod	_	_
4	mutant	mutant	JJ	JJ	_	5	amod	_	_
5	mouse	mouse	NN	NN	_	6	nsubj	_	_
6	shows	show	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	phenotype	phenotype	NN	NN	_	6	dobj	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	analogous	analogous	JJ	JJ	_	8	acl:relcl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	myelodysplastic	myelodysplastic	JJ	JJ	_	15	amod	_	_
15	syndrome	syndrome	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	thus	thus	RB	RB	_	19	advmod	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	serve	serve	VB	VB	_	6	conj	_	_
20	as	as	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	useful	useful	JJ	JJ	_	23	amod	_	_
23	model	model	NN	NN	_	19	nmod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	disorder	disorder	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Erythropoietin	erythropoietin	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Jak2	jak2	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	STAT5A	stat5a	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	STAT5B	stat5b	NN	NN	_	6	conj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	primary	primary	JJ	JJ	_	17	amod	_	_
14	cultured	culture	VBN	VBN	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
17	precursors	precursor	NNS	NNS	_	2	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	signaling	signaling	NN	NN	_	2	dobj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	erythropoietin	erythropoietin	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	13	case	_	_
7	highly	highly	RB	RB	_	13	advmod	_	_
8	purified	purify	VBN	VBN	_	13	amod	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	colony	colony	NN	NN	_	13	compound	_	_
11	forming	forming	NN	NN	_	13	compound	_	_
12	unit-erythroid	unit-erythroid	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	5	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	generated	generate	VBN	VBN	_	13	acl	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vitro	vitro	FW	FW	_	15	advmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	CD34(+)	cd34(+)	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	erythropoietin	erythropoietin	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	2	ccomp	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Jak2	jak2	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	STAT5A	stat5a	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	STAT5B	stat5b	NN	NN	_	9	conj	_	_
15	.	.	.	.	_	2	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Jak2	jak2	NN	NN	_	2	nmod	_	_
5	reaches	reach	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	peak	peak	NN	NN	_	5	dobj	_	_
8	around	around	IN	IN	_	10	case	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	minutes	minute	NNS	NNS	_	5	nmod	_	_
11	after	after	IN	IN	_	12	case	_	_
12	stimulation	stimulation	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	maximum	maximum	JJ	JJ	_	5	conj	_	_
16	at	at	IN	IN	_	18	case	_	_
17	5	5	CD	CD	_	18	nummod	_	_
18	U/mL	u/ml	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	erythropoietin	erythropoietin	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT5	stat5	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	translocation	translocation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	STAT5	stat5	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	nucleus	nucleus	NN	NN	_	9	nmod	_	_
16	as	as	IN	IN	_	17	mark	_	_
17	shown	show	VBN	VBN	_	6	advcl	_	_
18	by	by	IN	IN	_	22	case	_	_
19	electrophoretic	electrophoretic	JJ	JJ	_	22	amod	_	_
20	mobility	mobility	NN	NN	_	22	compound	_	_
21	shift	shift	NN	NN	_	22	compound	_	_
22	assay	assay	NN	NN	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	EMSA	emsa	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	using	use	VBG	VBG	_	22	acl	_	_
27	32Pi-labeled	32pi-labeled	JJ	JJ	_	30	amod	_	_
28	STAT5	stat5	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	26	dobj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	beta-casein	beta-casein	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	8	nsubjpass	_	_
3	STAT1	stat1	NN	NN	_	2	dep	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	STAT3	stat3	NN	NN	_	3	conj	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	precursors	precursor	NNS	NNS	_	8	nmod	_	_
13	after	after	IN	IN	_	14	case	_	_
14	stimulation	stimulation	NN	NN	_	8	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	erythropoietin	erythropoietin	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Crkl	crkl	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	6	det	_	_
4	SH2/SH3	sh2/sh3	NN	NN	_	6	compound	_	_
5	adapter	adapter	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	1	punct	_	_
8	becomes	become	VBZ	VBZ	_	0	root	_	_
9	coimmunoprecipitated	coimmunoprecipitate	VBN	VBN	_	8	xcomp	_	_
10	specifically	specifically	RB	RB	_	12	advmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	STAT5	stat5	NN	NN	_	9	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	erythropoietin-stimulated	erythropoietin-stimulated	JJ	JJ	_	16	amod	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	;	;	:	:	_	8	punct	_	_
18	although	although	IN	IN	_	21	mark	_	_
19	it	it	PRP	PRP	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	shown	show	VBN	VBN	_	8	parataxis	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	become	become	VB	VB	_	21	xcomp	_	_
24	associated	associate	VBN	VBN	_	23	xcomp	_	_
25	with	with	IN	IN	_	26	case	_	_
26	c-Cbl	c-cbl	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	studies	study	NNS	NNS	_	21	nmod	_	_
30	using	use	VBG	VBG	_	29	acl	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	lines	line	NNS	NNS	_	30	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	erythroid	erythroid	JJ	JJ	_	5	amod	_	_
5	precursors	precursor	NNS	NNS	_	8	nsubjpass	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	expanded	expand	VBN	VBN	_	0	root	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	8	advmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	sufficient	sufficient	JJ	JJ	_	13	amod	_	_
13	numbers	number	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	purity	purity	NN	NN	_	13	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	allow	allow	VB	VB	_	8	xcomp	_	_
18	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
19	usage	usage	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	signal	signal	NN	NN	_	23	compound	_	_
22	transduction	transduction	NN	NN	_	23	compound	_	_
23	studies	study	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	3	nsubj	_	_
3	sets	set	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	basis	basis	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	further	further	JJ	JJ	_	8	amod	_	_
8	studies	study	NNS	NNS	_	5	nmod	_	_
9	on	on	IN	IN	_	10	case	_	_
10	signaling	signaling	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	primary	primary	JJ	JJ	_	16	amod	_	_
13	cultured	culture	VBN	VBN	_	16	amod	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	precursors	precursor	NNS	NNS	_	10	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	which	which	WDT	WDT	_	21	nsubj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	turn	turn	NN	NN	_	21	nmod	_	_
21	contribute	contribute	VBP	VBP	_	3	dep	_	_
22	to	to	TO	TO	_	25	case	_	_
23	our	we	PRP$	PRP$	_	25	nmod:poss	_	_
24	better	better	JJR	JJR	_	25	amod	_	_
25	understanding	understanding	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	differentiation	differentiation	NN	NN	_	29	compound	_	_
29	processes	process	NNS	NNS	_	25	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	erythrocytes	erythrocyte	NNS	NNS	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	their	they	PRP$	PRP$	_	34	nmod:poss	_	_
34	precursors	precursor	NNS	NNS	_	31	conj	_	_
35	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	small	small	JJ	JJ	_	5	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	nonpeptidyl	nonpeptidyl	JJ	JJ	_	2	dep	_	_
5	mimic	mimic	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	granulocyte-colony-stimulating	granulocyte-colony-stimulating	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	5	nmod	_	_
9	-LSB-	-lsb-	-LRB-	-LRB-	_	10	punct	_	_
10	see	see	VB	VB	_	5	dep	_	_
11	commetns	commetn	NNS	NNS	_	10	dobj	_	_
12	-RSB-	-rsb-	-RRB-	-RRB-	_	10	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	nonpeptidyl	nonpeptidyl	JJ	JJ	_	4	amod	_	_
3	small	small	JJ	JJ	_	2	dep	_	_
4	molecule	molecule	NN	NN	_	21	nsubjpass	_	_
5	SB	sb	NN	NN	_	4	dep	_	_
6	247464	247464	CD	CD	_	5	nummod	_	_
7	,	,	,	,	_	4	punct	_	_
8	capable	capable	JJ	JJ	_	4	amod	_	_
9	of	of	IN	IN	_	10	mark	_	_
10	activating	activate	VBG	VBG	_	8	advcl	_	_
11	granulocyte-colony-stimulating	granulocyte-colony-stimulating	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	18	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	G-CSF	g-csf	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	signal	signal	NN	NN	_	18	compound	_	_
17	transduction	transduction	NN	NN	_	18	compound	_	_
18	pathways	pathway	NNS	NNS	_	10	dobj	_	_
19	,	,	,	,	_	4	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	identified	identify	VBN	VBN	_	0	root	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	high-throughput	high-throughput	JJ	JJ	_	25	amod	_	_
25	assay	assay	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	cultured	culture	VBN	VBN	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	21	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	Like	like	IN	IN	_	2	case	_	_
2	G-CSF	g-csf	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	SB	sb	NN	NN	_	6	nsubj	_	_
5	247464	247464	CD	CD	_	4	nummod	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	multiple	multiple	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	stimulated	stimulate	VBN	VBN	_	6	conj	_	_
15	primary	primary	JJ	JJ	_	19	amod	_	_
16	murine	murine	JJ	JJ	_	19	amod	_	_
17	bone	bone	NN	NN	_	19	compound	_	_
18	marrow	marrow	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	form	form	VB	VB	_	14	advcl	_	_
22	granulocytic	granulocytic	JJ	JJ	_	23	amod	_	_
23	colonies	colony	NNS	NNS	_	21	dobj	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vitro	vitro	FW	FW	_	21	advmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	elevated	elevated	JJ	JJ	_	0	root	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	neutrophil	neutrophil	NN	NN	_	7	compound	_	_
7	counts	count	NNS	NNS	_	3	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	mice	mouse	NNS	NNS	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	extracellular	extracellular	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	murine	murine	JJ	JJ	_	8	amod	_	_
7	G-CSF	g-csf	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	SB	sb	NN	NN	_	13	nmod	_	_
16	247464	247464	CD	CD	_	15	nummod	_	_
17	,	,	,	,	_	10	punct	_	_
18	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	compound	compound	NN	NN	_	22	nsubj	_	_
22	acts	act	VBZ	VBZ	_	18	ccomp	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	oligomerizing	oligomerize	VBG	VBG	_	22	advcl	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	chains	chain	NNS	NNS	_	24	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	small	small	JJ	JJ	_	7	amod	_	_
7	molecule	molecule	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	activate	activate	VB	VB	_	3	ccomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	receptor	receptor	NN	NN	_	9	dobj	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	normally	normally	RB	RB	_	14	advmod	_	_
14	binds	bind	VBZ	VBZ	_	11	acl:relcl	_	_
15	a	a	DT	DT	_	19	det	_	_
16	relatively	relatively	RB	RB	_	17	advmod	_	_
17	large	large	JJ	JJ	_	19	amod	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	ligand	ligand	NN	NN	_	14	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	2	nsubj	_	_
2	supports	support	VBZ	VBZ	_	0	root	_	_
3	in	in	FW	FW	_	6	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	differentiation	differentiation	NN	NN	_	2	dobj	_	_
7	via	via	IN	IN	_	11	case	_	_
8	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
9	specific	specific	JJ	JJ	_	11	amod	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	c-Mpl	c-mpl	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	leukemia	leukemia	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	TPO	tpo	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	acts	act	VBZ	VBZ	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	megakaryopoiesis	megakaryopoiesis	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	erythropoiesis	erythropoiesis	NN	NN	_	7	conj	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	12	advmod	_	_
12	and	and	CC	CC	_	5	advmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vivo	vivo	FW	FW	_	12	advmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	isolated	isolate	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	novel	novel	JJ	JJ	_	5	amod	_	_
5	subline	subline	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	UT-7/GMT	ut-7/gmt	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	from	from	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	leukemia	leukemia	NN	NN	_	15	compound	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	line	line	NN	NN	_	15	compound	_	_
15	UT-7/GM	ut-7/gm	NN	NN	_	2	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	N.	n.	NN	NN	_	18	compound	_	_
18	Komatsu	komatsu	NN	NN	_	2	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	et	et	FW	FW	_	18	dep	_	_
21	al.	al.	FW	FW	_	18	dep	_	_
22	,	,	,	,	_	18	punct	_	_
23	Blood	blood	NN	NN	_	18	dep	_	_
24	,	,	,	,	_	18	punct	_	_
25	89	89	CD	CD	_	27	nummod	_	_
26	:	:	:	:	_	27	punct	_	_
27	4021-4033	4021-4033	CD	CD	_	18	dep	_	_
28	,	,	,	,	_	18	punct	_	_
29	1997	1997	CD	CD	_	18	dep	_	_
30	)	)	-RRB-	-RRB-	_	18	punct	_	_
31	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	small	small	JJ	JJ	_	3	amod	_	_
3	population	population	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	UT-7/GM	ut-7/gm	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	positively	positively	RB	RB	_	8	advmod	_	_
8	stained	stain	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	hemoglobin	hemoglobin	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Hb	hb	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	after	after	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	7-day	7-day	JJ	JJ	_	17	amod	_	_
17	exposure	exposure	NN	NN	_	8	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	TPO	tpo	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	More	more	JJR	JJR	_	3	advmod	_	_
2	than	than	IN	IN	_	1	mwe	_	_
3	50	50	CD	CD	_	4	nummod	_	_
4	%	%	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	TPO-treated	tpo-treated	JJ	JJ	_	8	amod	_	_
7	UT-7/GMT	ut-7/gmt	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	positively	positively	RB	RB	_	10	advmod	_	_
10	stained	stain	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	Hb	hb	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	UT-7/GMT	ut-7/gmt	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	how	how	WRB	WRB	_	9	advmod	_	_
8	TPO	tpo	NN	NN	_	9	nsubj	_	_
9	promotes	promote	VBZ	VBZ	_	6	ccomp	_	_
10	hemoglobinization	hemoglobinization	NN	NN	_	9	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	TPO	tpo	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TPO	tpo	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	the	the	DT	DT	_	16	det	_	_
12	erythropoietin	erythropoietin	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	EPO	epo	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	receptor	receptor	NN	NN	_	8	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	competition	competition	NN	NN	_	2	nsubj	_	_
5	between	between	IN	IN	_	6	case	_	_
6	TPO	tpo	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	EPO	epo	NN	NN	_	6	conj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	binding	binding	NN	NN	_	4	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	EPO	epo	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	TPO	tpo	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	direct	direct	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	on	on	IN	IN	_	11	case	_	_
11	hemoglobinization	hemoglobinization	NN	NN	_	6	nmod	_	_
12	via	via	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	specific	specific	JJ	JJ	_	15	amod	_	_
15	receptor	receptor	NN	NN	_	6	nmod	_	_
16	on	on	IN	IN	_	18	case	_	_
17	UT-7/GMT	ut-7/gmt	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Isoelectric	isoelectric	JJ	JJ	_	2	amod	_	_
2	focusing	focusing	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	TPO	tpo	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	3	ccomp	_	_
7	fetal	fetal	JJ	JJ	_	11	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	adult	adult	JJ	JJ	_	7	conj	_	_
10	Hb	hb	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	6	dobj	_	_
12	,	,	,	,	_	6	punct	_	_
13	whereas	whereas	IN	IN	_	6	dep	_	_
14	EPO	epo	NN	NN	_	15	nsubj	_	_
15	induced	induce	VBD	VBD	_	6	parataxis	_	_
16	embryonic	embryonic	JJ	JJ	_	23	amod	_	_
17	,	,	,	,	_	16	punct	_	_
18	fetal	fetal	JJ	JJ	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	adult	adult	JJ	JJ	_	16	conj	_	_
22	Hb	hb	NN	NN	_	23	compound	_	_
23	synthesis	synthesis	NN	NN	_	15	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	TPO	tpo	NN	NN	_	8	nsubj	_	_
8	has	have	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	action	action	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	13	case	_	_
13	erythropoiesis	erythropoiesis	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Macrophages	macrophage	NNS	NNS	_	5	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	atheroma	atheroma	NN	NN	_	1	nmod	_	_
5	contain	contain	VBP	VBP	_	0	root	_	_
6	PPARgamma	ppargamma	NN	NN	_	5	dobj	_	_
7	:	:	:	:	_	5	punct	_	_
8	differentiation-dependent	differentiation-dependent	JJ	JJ	_	12	amod	_	_
9	peroxisomal	peroxisomal	JJ	JJ	_	12	amod	_	_
10	proliferator-activated	proliferator-activated	JJ	JJ	_	12	amod	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	gamma	gamma	NN	NN	_	5	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PPARgamma	ppargamma	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	expression	expression	NN	NN	_	12	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	reduction	reduction	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	MMP-9	mmp-9	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	12	nmod	_	_
22	through	through	IN	IN	_	24	case	_	_
23	PPARgamma	ppargamma	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	mononuclear	mononuclear	JJ	JJ	_	27	amod	_	_
27	phagocytes	phagocyte	NNS	NNS	_	24	nmod	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vitro	vitro	FW	FW	_	24	advmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Mononuclear	mononuclear	JJ	JJ	_	2	amod	_	_
2	phagocytes	phagocyte	NNS	NNS	_	3	nsubj	_	_
3	play	play	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	atherosclerosis	atherosclerosis	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
11	sequela	sequela	NN	NN	_	13	compound	_	_
12	plaque	plaque	NN	NN	_	13	compound	_	_
13	rupture	rupture	NN	NN	_	8	conj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	part	part	NN	NN	_	3	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	secretion	secretion	NN	NN	_	3	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	matrix	matrix	NN	NN	_	21	compound	_	_
21	metalloproteinases	metalloproteinase	NNS	NNS	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	MMPs	mmp	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	21	punct	_	_
26	including	include	VBG	VBG	_	27	case	_	_
27	MMP-9	mmp-9	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Peroxisomal	peroxisomal	JJ	JJ	_	4	amod	_	_
2	proliferator-activated	proliferator-activated	JJ	JJ	_	4	amod	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	gamma	gamma	NN	NN	_	18	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PPARgamma	ppargamma	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	4	appos	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	superfamily	superfamily	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	regulates	regulate	VBZ	VBZ	_	0	root	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	response	response	NN	NN	_	25	dep	_	_
23	to	to	TO	TO	_	25	case	_	_
24	various	various	JJ	JJ	_	25	amod	_	_
25	activators	activator	NNS	NNS	_	18	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	including	include	VBG	VBG	_	29	case	_	_
28	15-deoxy-delta12,14-prostaglandin	15-deoxy-delta12,14-prostaglandin	NN	NN	_	29	compound	_	_
29	J2	j2	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	34	det	_	_
32	antidiabetic	antidiabetic	JJ	JJ	_	34	amod	_	_
33	agent	agent	NN	NN	_	34	compound	_	_
34	troglitazone	troglitazone	NN	NN	_	29	conj	_	_
35	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PPARgamma	ppargamma	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	atherosclerosis	atherosclerosis	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	unexplored	unexplored	JJ	JJ	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	15	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	atherosclerotic	atherosclerotic	JJ	JJ	_	9	amod	_	_
9	lesions	lesion	NNS	NNS	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	n	n	NN	NN	_	12	nsubj	_	_
12	=	=	JJ	JJ	_	9	dep	_	_
13	12	12	CD	CD	_	12	dobj	_	_
14	)	)	-RRB-	-RRB-	_	12	punct	_	_
15	express	express	VBP	VBP	_	2	ccomp	_	_
16	immunostainable	immunostainable	JJ	JJ	_	17	amod	_	_
17	PPARgamma	ppargamma	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Normal	normal	JJ	JJ	_	3	amod	_	_
2	artery	artery	NN	NN	_	3	compound	_	_
3	specimens	specimen	NNS	NNS	_	9	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	n	n	NN	NN	_	6	nsubj	_	_
6	=	=	JJ	JJ	_	3	dep	_	_
7	6	6	CD	CD	_	6	dobj	_	_
8	)	)	-RRB-	-RRB-	_	6	punct	_	_
9	reveal	reveal	VBP	VBP	_	0	root	_	_
10	minimal	minimal	JJ	JJ	_	12	amod	_	_
11	immunoreactive	immunoreactive	JJ	JJ	_	12	amod	_	_
12	PPARgamma	ppargamma	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	9	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	monocytes	monocyte	NNS	NNS	_	15	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	monocyte-derived	monocyte-derived	JJ	JJ	_	5	amod	_	_
5	macrophages	macrophage	NNS	NNS	_	2	conj	_	_
6	cultured	culture	VBN	VBN	_	2	acl	_	_
7	for	for	IN	IN	_	9	case	_	_
8	6	6	CD	CD	_	9	nummod	_	_
9	days	day	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	5	5	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	6	nmod	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	serum	serum	NN	NN	_	12	dep	_	_
15	expressed	express	VBD	VBD	_	0	root	_	_
16	PPARgamma	ppargamma	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	protein	protein	NN	NN	_	17	conj	_	_
20	by	by	IN	IN	_	24	case	_	_
21	reverse	reverse	JJ	JJ	_	24	amod	_	_
22	transcription-polymerase	transcription-polymerase	NN	NN	_	24	compound	_	_
23	chain	chain	NN	NN	_	24	compound	_	_
24	reaction	reaction	NN	NN	_	15	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Western	western	NN	NN	_	27	compound	_	_
27	blotting	blotting	NN	NN	_	24	conj	_	_
28	,	,	,	,	_	15	punct	_	_
29	respectively	respectively	RB	RB	_	15	advmod	_	_
30	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	PPARgamma	ppargamma	NN	NN	_	6	compound	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	10	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	U937	u937	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	increased	increase	VBN	VBN	_	0	root	_	_
11	during	during	IN	IN	_	16	case	_	_
12	phorbol	phorbol	NN	NN	_	15	nmod:npmod	_	_
13	12-myristate	12-myristate	NN	NN	_	15	nmod:npmod	_	_
14	13	13	CD	CD	_	15	compound	_	_
15	acetate-induced	acetate-induced	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Stimulation	stimulation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PPARgamma	ppargamma	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	troglitazone	troglitazone	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	15-deoxy-delta12,14-prostaglandin	15-deoxy-delta12,14-prostaglandin	NN	NN	_	8	compound	_	_
8	J2	j2	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocyte-derived	monocyte-derived	JJ	JJ	_	12	amod	_	_
12	macrophages	macrophage	NNS	NNS	_	5	nmod	_	_
13	inhibited	inhibit	VBD	VBD	_	0	root	_	_
14	MMP-9	mmp-9	NN	NN	_	16	compound	_	_
15	gelatinolytic	gelatinolytic	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	concentration-dependent	concentration-dependent	JJ	JJ	_	20	amod	_	_
20	fashion	fashion	NN	NN	_	13	nmod	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	revealed	reveal	VBN	VBN	_	13	advcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	zymography	zymography	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	3	nsubj	_	_
3	correlates	correlate	VBZ	VBZ	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	decreased	decrease	VBN	VBN	_	7	amod	_	_
6	MMP-9	mmp-9	NN	NN	_	7	compound	_	_
7	secretion	secretion	NN	NN	_	3	nmod	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	determined	determine	VBN	VBN	_	3	advcl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	Western	western	NN	NN	_	12	compound	_	_
12	blotting	blotting	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	PPARgamma	ppargamma	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	present	present	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	macrophages	macrophage	NNS	NNS	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	atherosclerotic	atherosclerotic	JJ	JJ	_	11	amod	_	_
11	lesions	lesion	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	regulate	regulate	VB	VB	_	5	conj	_	_
15	expression	expression	NN	NN	_	14	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	activity	activity	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	MMP-9	mmp-9	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	an	a	DT	DT	_	22	det	_	_
22	enzyme	enzyme	NN	NN	_	19	appos	_	_
23	implicated	implicate	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	plaque	plaque	NN	NN	_	26	compound	_	_
26	rupture	rupture	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	PPARgamma	ppargamma	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	likely	likely	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	8	mark	_	_
5	be	be	VB	VB	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	regulator	regulator	NN	NN	_	3	xcomp	_	_
9	of	of	IN	IN	_	11	case	_	_
10	monocyte/macrophage	monocyte/macrophage	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	relevance	relevance	NN	NN	_	11	nmod	_	_
14	for	for	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	atherosclerotic	atherosclerotic	JJ	JJ	_	17	amod	_	_
17	disease	disease	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	16	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	monocytes	monocyte	NNS	NNS	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	4	conj	_	_
11	derived	derive	VBN	VBN	_	4	acl	_	_
12	from	from	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	lupus	lupus	NN	NN	_	13	nmod	_	_
16	express	express	VBP	VBP	_	0	root	_	_
17	estrogen	estrogen	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	transcripts	transcript	NNS	NNS	_	16	dobj	_	_
20	similar	similar	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	those	those	DT	DT	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	normal	normal	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	identify	identify	VB	VB	_	1	acl	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	characterize	characterize	VB	VB	_	4	conj	_	_
7	estrogen	estrogen	NN	NN	_	12	compound	_	_
8	receptor	receptor	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	ER	er	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	transcripts	transcript	NNS	NNS	_	4	dobj	_	_
13	expressed	express	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	patients	patient	NNS	NNS	_	16	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	systemic	systemic	JJ	JJ	_	22	amod	_	_
21	lupus	lupus	NN	NN	_	22	compound	_	_
22	erythematosus	erythematosus	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	SLE	sle	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	18	cc	_	_
27	healthy	healthy	JJ	JJ	_	28	amod	_	_
28	donors	donor	NNS	NNS	_	18	conj	_	_
29	.	.	.	.	_	1	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Peripheral	peripheral	JJ	JJ	_	5	amod	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	monocytes	monocyte	NNS	NNS	_	10	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	prepared	prepare	VBN	VBN	_	1	appos	_	_
11	from	from	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	SLE	sle	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	n	n	NN	NN	_	17	nsubj	_	_
17	=	=	JJ	JJ	_	12	dep	_	_
18	6	6	CD	CD	_	17	dobj	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	healthy	healthy	JJ	JJ	_	22	amod	_	_
22	donors	donor	NNS	NNS	_	12	conj	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	n	n	NN	NN	_	25	nsubj	_	_
25	=	=	JJ	JJ	_	22	dep	_	_
26	8	8	CD	CD	_	25	dobj	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	.	.	.	.	_	1	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	separated	separate	VBN	VBN	_	0	root	_	_
5	into	into	IN	IN	_	6	case	_	_
6	CD4	cd4	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CD8	cd8	NN	NN	_	6	conj	_	_
9	.	.	.	.	_	4	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	monocytes	monocyte	NNS	NNS	_	7	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	conj	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	stimulated	stimulate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	estradiol	estradiol	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	PMA	pma	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	ionomycin	ionomycin	NN	NN	_	9	conj	_	_
15	.	.	.	.	_	7	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus-transformed	virus-transformed	JJ	JJ	_	5	amod	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	30	nsubjpass	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	n	n	NN	NN	_	8	nsubj	_	_
8	=	=	JJ	JJ	_	5	dep	_	_
9	7	7	CD	CD	_	8	dobj	_	_
10	)	)	-RRB-	-RRB-	_	8	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	hybridomas	hybridoma	NNS	NNS	_	5	conj	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	n	n	NN	NN	_	17	nsubj	_	_
17	=	=	JJ	JJ	_	14	dep	_	_
18	2	2	LS	LS	_	17	dobj	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	established	establish	VBN	VBN	_	5	acl	_	_
21	from	from	IN	IN	_	22	case	_	_
22	patients	patient	NNS	NNS	_	20	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	SLE	sle	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	a	a	DT	DT	_	28	det	_	_
27	healthy	healthy	JJ	JJ	_	28	amod	_	_
28	individual	individual	JJ	JJ	_	22	conj	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	used	use	VBN	VBN	_	0	root	_	_
31	as	as	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cell	cell	NN	NN	_	30	nmod	_	_
35	source	source	RB	RB	_	34	advmod	_	_
36	.	.	.	.	_	30	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	ER	er	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	14	case	_	_
9	reverse	reverse	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	nmod:npmod	_	_
11	nested	nested	JJ	JJ	_	14	amod	_	_
12	polymerase	polymerase	NN	NN	_	14	compound	_	_
13	chain	chain	NN	NN	_	14	compound	_	_
14	reaction	reaction	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Amplified	amplified	JJ	JJ	_	2	amod	_	_
2	cDNA	cdna	NN	NN	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	sequenced	sequence	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	standard	standard	JJ	JJ	_	7	amod	_	_
7	methods	method	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	5	case	_	_
4	all	all	DT	DT	_	5	det	_	_
5	cells	cell	NNS	NNS	_	11	nmod	_	_
6	tested	test	VBN	VBN	_	5	acl	_	_
7	,	,	,	,	_	11	punct	_	_
8	ER	er	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	1	appos	_	_
12	without	without	IN	IN	_	16	case	_	_
13	prior	prior	JJ	JJ	_	16	amod	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	stimulation	stimulation	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Partial	partial	JJ	JJ	_	2	amod	_	_
2	sequences	sequence	NNS	NNS	_	8	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	exons	exon	NNS	NNS	_	2	nmod	_	_
5	1-8	1-8	CD	CD	_	4	nummod	_	_
6	were	be	VBD	VBD	_	8	cop	_	_
7	nearly	nearly	RB	RB	_	8	advmod	_	_
8	identical	identical	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	published	publish	VBN	VBN	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	ER	er	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	were	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	notable	notable	JJ	JJ	_	5	amod	_	_
5	differences	difference	NNS	NNS	_	2	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	ER	er	NN	NN	_	9	compound	_	_
9	transcripts	transcript	NNS	NNS	_	2	nmod	_	_
10	between	between	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	2	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	controls	control	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	2	punct	_	_

1	Variant	variant	JJ	JJ	_	3	amod	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	transcripts	transcript	NNS	NNS	_	19	nsubjpass	_	_
4	lacking	lack	VBG	VBG	_	3	acl	_	_
5	exon	exon	NN	NN	_	4	dobj	_	_
6	5	5	CD	CD	_	5	nummod	_	_
7	or	or	CC	CC	_	5	cc	_	_
8	exon	exon	NN	NN	_	5	conj	_	_
9	7	7	CD	CD	_	8	nummod	_	_
10	,	,	,	,	_	5	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	encodes	encode	VBZ	VBZ	_	5	acl:relcl	_	_
13	the	the	DT	DT	_	16	det	_	_
14	hormone	hormone	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	12	dobj	_	_
17	,	,	,	,	_	5	punct	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	identified	identify	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	majority	majority	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	19	punct	_	_

1	Precise	precise	JJ	JJ	_	2	amod	_	_
2	deletion	deletion	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	exons	exon	NNS	NNS	_	2	nmod	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	they	they	PRP	PRP	_	12	nsubj	_	_
9	are	be	VBP	VBP	_	12	cop	_	_
10	alternatively	alternatively	RB	RB	_	11	advmod	_	_
11	spliced	splice	VBN	VBN	_	12	amod	_	_
12	transcripts	transcript	NNS	NNS	_	6	ccomp	_	_
13	.	.	.	.	_	6	punct	_	_

1	Whether	whether	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	detected	detected	JJ	JJ	_	4	amod	_	_
4	transcripts	transcript	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	translated	translate	VBN	VBN	_	11	csubj	_	_
7	into	into	IN	IN	_	10	case	_	_
8	functional	functional	JJ	JJ	_	10	amod	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	6	nmod	_	_
11	remains	remain	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	determined	determine	VBN	VBN	_	11	xcomp	_	_
15	.	.	.	.	_	11	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	stimulation	stimulation	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	affect	affect	VB	VB	_	0	root	_	_
7	ER	er	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	variants	variant	NNS	NNS	_	2	nmod	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	correlate	correlate	VB	VB	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	disease	disease	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	medication	medication	NN	NN	_	10	conj	_	_
13	.	.	.	.	_	7	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Monocytes	monocyte	NNS	NNS	_	13	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	conj	_	_
7	,	,	,	,	_	3	punct	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	3	conj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	3	nmod	_	_
13	express	express	VBP	VBP	_	1	appos	_	_
14	transcripts	transcript	NNS	NNS	_	13	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	normal	normal	JJ	JJ	_	20	amod	_	_
18	wild	wild	JJ	JJ	_	20	amod	_	_
19	type	type	NN	NN	_	20	compound	_	_
20	ER	er	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	26	det	_	_
23	hormone	hormone	NN	NN	_	26	compound	_	_
24	binding	binding	NN	NN	_	26	compound	_	_
25	domain	domain	NN	NN	_	26	compound	_	_
26	variants	variant	NNS	NNS	_	20	conj	_	_
27	in	in	FW	FW	_	28	compound	_	_
28	vivo	vivo	FW	FW	_	13	advmod	_	_
29	.	.	.	.	_	1	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	human	human	JJ	JJ	_	7	amod	_	_
4	anti-porcine	anti-porcine	JJ	JJ	_	7	amod	_	_
5	T-cell	t-cell	NN	NN	_	7	compound	_	_
6	immune	immune	JJ	JJ	_	7	amod	_	_
7	responses	response	NNS	NNS	_	1	nmod	_	_
8	by	by	IN	IN	_	15	case	_	_
9	major	major	JJ	JJ	_	15	amod	_	_
10	histocompatibility	histocompatibility	NN	NN	_	15	compound	_	_
11	complex	complex	NN	NN	_	15	compound	_	_
12	class	class	NN	NN	_	15	compound	_	_
13	II	ii	CD	CD	_	15	nummod	_	_
14	transactivator	transactivator	NN	NN	_	15	compound	_	_
15	constructs	construct	NNS	NNS	_	1	nmod	_	_
16	lacking	lack	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	amino	amino	NN	NN	_	20	compound	_	_
19	terminal	terminal	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	6	det	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	transactivator	transactivator	NN	NN	_	16	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CIITA	ciita	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	16	cop	_	_
11	a	a	DT	DT	_	16	det	_	_
12	bi-	bi-	JJ	JJ	_	16	amod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	multifunctional	multifunctional	JJ	JJ	_	12	conj	_	_
15	domain	domain	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	1	appos	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	acts	act	VBZ	VBZ	_	16	acl:relcl	_	_
19	as	as	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activator	activator	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	plays	play	VBZ	VBZ	_	18	conj	_	_
25	a	a	DT	DT	_	27	det	_	_
26	critical	critical	JJ	JJ	_	27	amod	_	_
27	role	role	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	expression	expression	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	MHC	mhc	NN	NN	_	35	compound	_	_
33	class	class	NN	NN	_	35	compound	_	_
34	II	ii	CD	CD	_	35	nummod	_	_
35	genes	gene	NNS	NNS	_	30	nmod	_	_
36	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	27	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	mutated	mutate	VBN	VBN	_	8	amod	_	_
8	form	form	NN	NN	_	27	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	CIITA	ciita	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	coding	code	VBG	VBG	_	13	acl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	protein	protein	NN	NN	_	15	nmod	_	_
19	lacking	lack	VBG	VBG	_	18	acl	_	_
20	the	the	DT	DT	_	25	det	_	_
21	amino	amino	NN	NN	_	25	compound	_	_
22	terminal	terminal	JJ	JJ	_	25	amod	_	_
23	151	151	CD	CD	_	25	nummod	_	_
24	amino	amino	NN	NN	_	25	compound	_	_
25	acids	acid	NNS	NNS	_	19	dobj	_	_
26	,	,	,	,	_	13	punct	_	_
27	acts	act	VBZ	VBZ	_	4	ccomp	_	_
28	as	as	IN	IN	_	32	case	_	_
29	a	a	DT	DT	_	32	det	_	_
30	potent	potent	JJ	JJ	_	32	amod	_	_
31	dominant-negative	dominant-negative	JJ	JJ	_	32	amod	_	_
32	suppressor	suppressor	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	HLA	hla	NN	NN	_	37	compound	_	_
35	class	class	NN	NN	_	37	compound	_	_
36	II	ii	CD	CD	_	37	nummod	_	_
37	expression	expression	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	Porcine	porcine	NN	NN	_	5	compound	_	_
2	MHC	mhc	NN	NN	_	5	compound	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	antigens	antigen	NNS	NNS	_	8	nsubj	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	potent	potent	JJ	JJ	_	8	amod	_	_
8	stimulators	stimulator	NNS	NNS	_	0	root	_	_
9	of	of	IN	IN	_	12	case	_	_
10	direct	direct	JJ	JJ	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	recognition	recognition	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	CD4+	cd4+	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	are	be	VBP	VBP	_	23	cop	_	_
20	,	,	,	,	_	23	punct	_	_
21	therefore	therefore	RB	RB	_	23	advmod	_	_
22	,	,	,	,	_	23	punct	_	_
23	likely	likely	JJ	JJ	_	8	conj	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	play	play	VB	VB	_	23	xcomp	_	_
26	an	a	DT	DT	_	28	det	_	_
27	important	important	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	rejection	rejection	NN	NN	_	32	compound	_	_
32	responses	response	NNS	NNS	_	25	nmod	_	_
33	to	to	TO	TO	_	36	case	_	_
34	transgenic	transgenic	JJ	JJ	_	36	amod	_	_
35	pig	pig	NN	NN	_	36	compound	_	_
36	donors	donor	NNS	NNS	_	32	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	clinical	clinical	JJ	JJ	_	39	amod	_	_
39	xenotransplantation	xenotransplantation	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	6	nsubjpass	_	_
2	were	be	VBD	VBD	_	6	auxpass	_	_
3	,	,	,	,	_	6	punct	_	_
4	therefore	therefore	RB	RB	_	6	advmod	_	_
5	,	,	,	,	_	6	punct	_	_
6	interested	interest	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	examining	examine	VBG	VBG	_	6	advcl	_	_
9	mutated	mutate	VBN	VBN	_	11	amod	_	_
10	CIITA	ciita	NN	NN	_	11	compound	_	_
11	constructs	construct	NNS	NNS	_	8	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	effect	effect	NN	NN	_	8	nmod	_	_
15	on	on	IN	IN	_	20	case	_	_
16	porcine	porcine	NN	NN	_	20	compound	_	_
17	MHC	mhc	NN	NN	_	20	compound	_	_
18	class	class	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	expression	expression	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Stable	stable	JJ	JJ	_	4	amod	_	_
4	transfectants	transfectant	NNS	NNS	_	18	nsubjpass	_	_
5	of	of	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	porcine	porcine	NN	NN	_	12	compound	_	_
8	vascular	vascular	JJ	JJ	_	12	amod	_	_
9	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	line	line	NN	NN	_	12	compound	_	_
12	PIEC	piec	NN	NN	_	4	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	mutated	mutate	VBN	VBN	_	16	amod	_	_
15	CIITA	ciita	NN	NN	_	16	compound	_	_
16	constructs	construct	NNS	NNS	_	4	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	tested	test	VBN	VBN	_	1	appos	_	_
19	for	for	IN	IN	_	23	case	_	_
20	SLA-DR	sla-dr	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	SLA-DQ	sla-dq	NN	NN	_	20	conj	_	_
23	induction	induction	NN	NN	_	18	nmod	_	_
24	by	by	IN	IN	_	27	case	_	_
25	recombinant	recombinant	JJ	JJ	_	27	amod	_	_
26	porcine	porcine	NN	NN	_	27	compound	_	_
27	interferon-gamma	interferon-gamma	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	1	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	transfectants	transfectant	NNS	NNS	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	porcine	porcine	NN	NN	_	8	compound	_	_
6	B-cell	b-cell	NN	NN	_	8	compound	_	_
7	line	line	NN	NN	_	8	compound	_	_
8	L23	l23	NN	NN	_	2	nmod	_	_
9	with	with	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	mutated	mutate	VBN	VBN	_	13	amod	_	_
12	CIITA	ciita	NN	NN	_	13	compound	_	_
13	constructs	construct	NNS	NNS	_	2	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	tested	test	VBN	VBN	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	suppression	suppression	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	constitutive	constitutive	JJ	JJ	_	21	amod	_	_
21	SLA-DR	sla-dr	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	SLA-DQ	sla-dq	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	15	punct	_	_

1	T-cell	t-cell	NN	NN	_	3	compound	_	_
2	proliferation	proliferation	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	performed	perform	VBN	VBN	_	0	root	_	_
6	using	use	VBG	VBG	_	5	xcomp	_	_
7	highly	highly	RB	RB	_	8	advmod	_	_
8	purified	purify	VBN	VBN	_	12	amod	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	dobj	_	_
13	.	.	.	.	_	5	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	FW	FW	_	5	dep	_	_
4	preliminary	preliminary	JJ	JJ	_	5	amod	_	_
5	studies	study	NNS	NNS	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	1	appos	_	_
9	that	that	IN	IN	_	20	mark	_	_
10	transfection	transfection	NN	NN	_	20	nsubj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	PIEC	piec	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	10	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	full-length	full-length	JJ	JJ	_	19	amod	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	CIITA	ciita	NN	NN	_	19	compound	_	_
19	constructs	construct	NNS	NNS	_	10	nmod	_	_
20	resulted	result	VBD	VBD	_	8	ccomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	strong	strong	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	SLA-DR	sla-dr	NN	NN	_	28	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	SLA-DQ	sla-dq	NN	NN	_	25	conj	_	_
28	antigens	antigen	NNS	NNS	_	23	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	thus	thus	RB	RB	_	31	advmod	_	_
31	establishing	establish	VBG	VBG	_	20	xcomp	_	_
32	the	the	DT	DT	_	34	det	_	_
33	cross-species	cross-species	JJ	JJ	_	34	amod	_	_
34	effectiveness	effectiveness	NN	NN	_	31	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	CIITA	ciita	NN	NN	_	34	nmod	_	_
38	in	in	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	pig	pig	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	mutated	mutate	VBN	VBN	_	5	amod	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	CIITA	ciita	NN	NN	_	5	compound	_	_
5	constructs	construct	NNS	NNS	_	10	nsubjpass	_	_
6	were	be	VBD	VBD	_	10	auxpass	_	_
7	,	,	,	,	_	10	punct	_	_
8	therefore	therefore	RB	RB	_	10	advmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	tested	test	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	pig	pig	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	PIEC	piec	NN	NN	_	2	compound	_	_
2	clones	clone	NNS	NNS	_	10	nsubj	_	_
3	stably	stably	RB	RB	_	4	advmod	_	_
4	transfected	transfect	VBN	VBN	_	2	acl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	one	one	CD	CD	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	constructs	construct	NNS	NNS	_	6	nmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	up	up	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	99	99	CD	CD	_	14	dep	_	_
14	%	%	NN	NN	_	15	dep	_	_
15	suppression	suppression	NN	NN	_	10	dobj	_	_
16	of	of	IN	IN	_	21	case	_	_
17	SLA-DR	sla-dr	NN	NN	_	21	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	SLA-DQ	sla-dq	NN	NN	_	17	conj	_	_
20	antigen	antigen	NN	NN	_	21	compound	_	_
21	induction	induction	NN	NN	_	15	nmod	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	marked	marked	JJ	JJ	_	10	conj	_	_
24	suppression	suppression	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	SLA-DRA	sla-dra	NN	NN	_	28	compound	_	_
27	mRNA	mrna	NN	NN	_	28	compound	_	_
28	induction	induction	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	transient	transient	JJ	JJ	_	4	amod	_	_
4	transfection	transfection	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	porcine	porcine	NN	NN	_	10	compound	_	_
8	B-cell	b-cell	NN	NN	_	10	compound	_	_
9	line	line	NN	NN	_	10	compound	_	_
10	L23	l23	NN	NN	_	4	nmod	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	up	up	RB	RB	_	14	advmod	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	90	90	CD	CD	_	15	dep	_	_
15	%	%	NN	NN	_	16	dep	_	_
16	suppression	suppression	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	constitutive	constitutive	JJ	JJ	_	19	amod	_	_
19	SLA-DR	sla-dr	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	SLA-DQ	sla-dq	NN	NN	_	23	compound	_	_
22	antigen	antigen	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	conj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	5-8	5-8	CD	CD	_	26	nummod	_	_
26	days	day	NNS	NNS	_	16	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	interferon-gamma-stimulated	interferon-gamma-stimulated	JJ	JJ	_	7	amod	_	_
6	PIEC	piec	NN	NN	_	7	compound	_	_
7	clones	clone	NNS	NNS	_	14	nsubj	_	_
8	transfected	transfect	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	13	case	_	_
10	this	this	DT	DT	_	13	det	_	_
11	mutated	mutate	VBN	VBN	_	13	amod	_	_
12	CIITA	ciita	NN	NN	_	13	compound	_	_
13	construct	construct	NN	NN	_	8	nmod	_	_
14	failed	fail	VBD	VBD	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	stimulate	stimulate	VB	VB	_	14	xcomp	_	_
17	purified	purify	VBN	VBN	_	21	amod	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	CD4+	cd4+	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	16	dobj	_	_
22	.	.	.	.	_	14	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Mutated	mutated	JJ	JJ	_	6	amod	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	CIITA	ciita	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	9	nsubj	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	potent	potent	JJ	JJ	_	9	amod	_	_
9	suppressors	suppressor	NNS	NNS	_	1	appos	_	_
10	of	of	IN	IN	_	15	case	_	_
11	porcine	porcine	NN	NN	_	15	compound	_	_
12	MHC	mhc	NN	NN	_	15	compound	_	_
13	class	class	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	expression	expression	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Redox	redox	NN	NN	_	2	compound	_	_
2	signals	signal	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	conj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Accumulating	accumulating	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	10	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	laboratories	laboratory	NNS	NNS	_	5	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	recently	recently	RB	RB	_	10	advmod	_	_
10	indicated	indicate	VBN	VBN	_	0	root	_	_
11	that	that	IN	IN	_	27	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	response	response	NN	NN	_	27	nsubj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	13	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	alterations	alteration	NNS	NNS	_	13	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	redox	redox	NN	NN	_	23	compound	_	_
23	homeostasis	homeostasis	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	cells	cell	NNS	NNS	_	23	nmod	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	play	play	VB	VB	_	10	ccomp	_	_
28	an	a	DT	DT	_	30	det	_	_
29	important	important	JJ	JJ	_	30	amod	_	_
30	role	role	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	32	mark	_	_
32	modulating	modulate	VBG	VBG	_	27	advcl	_	_
33	immune	immune	JJ	JJ	_	34	amod	_	_
34	function	function	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	recognized	recognize	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	regulate	regulate	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	genes	gene	NNS	NNS	_	11	nmod	_	_
14	necessary	necessary	JJ	JJ	_	11	amod	_	_
15	for	for	IN	IN	_	19	case	_	_
16	normal	normal	JJ	JJ	_	19	amod	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	responses	response	NNS	NNS	_	14	nmod	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	IL-2	il-2	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	IL-6	il-6	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	IL-8	il-8	NN	NN	_	21	conj	_	_
26	,	,	,	,	_	21	punct	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	several	several	JJ	JJ	_	32	amod	_	_
29	T	t	NN	NN	_	32	compound	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	surface	surface	NN	NN	_	32	compound	_	_
32	receptors	receptor	NNS	NNS	_	21	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	Diminished	diminished	JJ	JJ	_	3	amod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	occur	occur	VB	VB	_	6	xcomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	aging	aging	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
16	that	that	IN	IN	_	22	mark	_	_
17	impaired	impaired	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	22	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	18	nmod	_	_
21	might	might	MD	MD	_	22	aux	_	_
22	occur	occur	VB	VB	_	15	ccomp	_	_
23	during	during	IN	IN	_	25	case	_	_
24	cellular	cellular	JJ	JJ	_	25	amod	_	_
25	senescence	senescence	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	aberrancies	aberrancy	NNS	NNS	_	10	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	implicated	implicate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	immunopathogenesis	immunopathogenesis	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	diseases	disease	NNS	NNS	_	13	nmod	_	_
16	involving	involve	VBG	VBG	_	15	acl	_	_
17	immune	immune	JJ	JJ	_	20	amod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	inflammatory	inflammatory	JJ	JJ	_	17	conj	_	_
20	processes	process	NNS	NNS	_	16	dobj	_	_
21	such	such	JJ	JJ	_	23	case	_	_
22	as	as	IN	IN	_	21	mwe	_	_
23	atherosclerosis	atherosclerosis	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	HIV-1	hiv-1	NN	NN	_	26	compound	_	_
26	infection	infection	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	25	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	H2O2	h2o2	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	other	other	JJ	JJ	_	9	amod	_	_
7	reactive	reactive	JJ	JJ	_	9	amod	_	_
8	oxygen	oxygen	NN	NN	_	9	compound	_	_
9	species	species	NNS	NNS	_	4	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	ROS	ros	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	as	as	IN	IN	_	17	case	_	_
14	an	a	DT	DT	_	17	det	_	_
15	integratory	integratory	JJ	JJ	_	17	amod	_	_
16	secondary	secondary	JJ	JJ	_	17	amod	_	_
17	messenger	messenger	NN	NN	_	2	nmod	_	_
18	for	for	IN	IN	_	22	case	_	_
19	divergent	divergent	JJ	JJ	_	22	amod	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	signals	signal	NNS	NNS	_	17	nmod	_	_
23	has	have	VBZ	VBZ	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	complicated	complicate	VBN	VBN	_	0	root	_	_
26	by	by	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	fact	fact	NN	NN	_	25	nmod	_	_
29	that	that	IN	IN	_	39	mark	_	_
30	various	various	JJ	JJ	_	33	amod	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	39	nsubj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	peripheral	peripheral	JJ	JJ	_	38	amod	_	_
36	blood	blood	NN	NN	_	38	compound	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	33	conj	_	_
39	differ	differ	VBP	VBP	_	28	ccomp	_	_
40	markedly	markedly	RB	RB	_	39	advmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	levels	level	NNS	NNS	_	39	nmod	_	_
44	of	of	IN	IN	_	46	case	_	_
45	NF-kappaB	nf-kappab	NN	NN	_	46	compound	_	_
46	activation	activation	NN	NN	_	43	nmod	_	_
47	induced	induce	VBN	VBN	_	46	acl	_	_
48	by	by	IN	IN	_	50	case	_	_
49	oxidant	oxidant	JJ	JJ	_	50	amod	_	_
50	stress	stress	NN	NN	_	47	nmod	_	_
51	.	.	.	.	_	25	punct	_	_

1	Additionally	additionally	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	proposed	proposed	JJ	JJ	_	4	amod	_	_
4	pathways	pathway	NNS	NNS	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	based	base	VBN	VBN	_	0	root	_	_
11	on	on	IN	IN	_	13	case	_	_
12	indirect	indirect	JJ	JJ	_	13	amod	_	_
13	evidence	evidence	NN	NN	_	10	nmod	_	_
14	provided	provide	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	experiments	experiment	NNS	NNS	_	14	nmod	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	used	use	VBD	VBD	_	16	acl:relcl	_	_
19	antioxidants	antioxidant	NNS	NNS	_	18	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	inhibit	inhibit	VB	VB	_	18	advcl	_	_
22	active	active	JJ	JJ	_	24	amod	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	24	compound	_	_
24	formation	formation	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	10	punct	_	_

1	Further	further	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	complete	complete	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	at	at	IN	IN	_	10	case	_	_
10	least	least	JJS	JJS	_	11	nmod:npmod	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	signals	signal	NNS	NNS	_	8	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	one	one	CD	CD	_	12	appos	_	_
15	that	that	IN	IN	_	16	nsubj	_	_
16	stimulates	stimulate	VBZ	VBZ	_	14	acl:relcl	_	_
17	an	a	DT	DT	_	18	det	_	_
18	increase	increase	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
21	calcium	calcium	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	one	one	CD	CD	_	14	conj	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	stimulates	stimulate	VBZ	VBZ	_	23	acl:relcl	_	_
26	enzymatic	enzymatic	JJ	JJ	_	27	amod	_	_
27	processes	process	NNS	NNS	_	25	dobj	_	_
28	including	include	VBG	VBG	_	29	case	_	_
29	kinases	kinase	NNS	NNS	_	27	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Similarly	similarly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	substantial	substantial	JJ	JJ	_	4	amod	_	_
4	evidence	evidence	NN	NN	_	5	nsubj	_	_
5	indicates	indicate	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	full	full	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
11	requires	require	VBZ	VBZ	_	5	ccomp	_	_
12	dual	dual	JJ	JJ	_	13	amod	_	_
13	signals	signal	NNS	NNS	_	11	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	H2O2	h2o2	NN	NN	_	2	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	ROS	ros	NN	NN	_	4	conj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	2	acl	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	signals	signal	NNS	NNS	_	9	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	functional	functional	JJ	JJ	_	15	amod	_	_
15	responses	response	NNS	NNS	_	12	conj	_	_
16	by	by	IN	IN	_	19	case	_	_
17	these	these	DT	DT	_	19	det	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	mechanisms	mechanism	NNS	NNS	_	9	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	reviewed	review	VBN	VBN	_	0	root	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	specific	specific	JJ	JJ	_	25	amod	_	_
25	response	response	NN	NN	_	35	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	25	nmod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	redox	redox	NN	NN	_	30	compound	_	_
30	changes	change	NNS	NNS	_	25	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	examined	examine	VBN	VBN	_	21	conj	_	_
36	.	.	.	.	_	21	punct	_	_

1	Data	datum	NNS	NNS	_	4	nsubjpass	_	_
2	are	be	VBP	VBP	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	presented	present	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	suggest	suggest	VB	VB	_	4	xcomp	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	redox	redox	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	16	nsubj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	relevant	relevant	JJ	JJ	_	6	ccomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	immune-related	immune-related	JJ	JJ	_	19	amod	_	_
19	diseases	disease	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	to	to	TO	TO	_	22	case	_	_
22	aging	aging	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Ciprofloxacin	ciprofloxacin	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	6	det	_	_
4	immunomodulatory	immunomodulatory	JJ	JJ	_	6	amod	_	_
5	stress	stress	NN	NN	_	6	compound	_	_
6	response	response	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Exposure	exposure	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	adverse	adverse	JJ	JJ	_	7	amod	_	_
6	environmental	environmental	JJ	JJ	_	7	amod	_	_
7	conditions	condition	NNS	NNS	_	1	nmod	_	_
8	invokes	invoke	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	genetically	genetically	RB	RB	_	11	advmod	_	_
11	programmed	program	VBN	VBN	_	12	amod	_	_
12	series	series	NNS	NNS	_	8	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	events	event	NNS	NNS	_	12	nmod	_	_
15	resulting	result	VBG	VBG	_	12	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	induction	induction	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	specific	specific	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	fluoroquinolone	fluoroquinolone	NN	NN	_	4	compound	_	_
3	antibiotic	antibiotic	JJ	JJ	_	4	amod	_	_
4	ciprofloxacin	ciprofloxacin	NN	NN	_	8	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	recently	recently	RB	RB	_	8	advmod	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	reported	report	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	upregulate	upregulate	VB	VB	_	8	xcomp	_	_
11	interleukin-2	interleukin-2	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IL-2	il-2	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	induction	induction	NN	NN	_	10	dobj	_	_
17	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	investigation	investigation	NN	NN	_	29	nmod	_	_
5	,	,	,	,	_	29	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	29	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	ciprofloxacin	ciprofloxacin	NN	NN	_	7	nmod	_	_
10	at	at	IN	IN	_	12	case	_	_
11	supratherapeutic	supratherapeutic	JJ	JJ	_	12	amod	_	_
12	concentrations	concentration	NNS	NNS	_	7	nmod	_	_
13	on	on	IN	IN	_	21	case	_	_
14	immediate-early	immediate-early	JJ	JJ	_	21	amod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	&lt;	&lt;	JJR	JJR	_	17	advmod	_	_
17	2	2	CD	CD	_	18	dep	_	_
18	h	h	NN	NN	_	21	dep	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	7	nmod	_	_
22	in	in	IN	IN	_	27	case	_	_
23	primary	primary	JJ	JJ	_	27	amod	_	_
24	human	human	JJ	JJ	_	27	amod	_	_
25	peripheral	peripheral	JJ	JJ	_	27	amod	_	_
26	blood	blood	NN	NN	_	27	compound	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	studied	study	VBN	VBN	_	0	root	_	_
30	with	with	IN	IN	_	32	case	_	_
31	Northern	northern	NN	NN	_	32	compound	_	_
32	blots	blot	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	29	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	24	nmod	_	_
3	,	,	,	,	_	24	punct	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	24	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	IL-2	il-2	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	metallothionein	metallothionein	NN	NN	_	7	conj	_	_
10	enhancer	enhancer	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	regions	region	NNS	NNS	_	10	conj	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	10	conj	_	_
17	AP-1	ap-1	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	NF-AT	nf-at	NN	NN	_	17	conj	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	analyzed	analyze	VBN	VBN	_	0	root	_	_
25	by	by	IN	IN	_	27	case	_	_
26	chloramphenicol	chloramphenicol	NN	NN	_	27	compound	_	_
27	acetyltransferase	acetyltransferase	NN	NN	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	CAT	cat	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	electrophoretic	electrophoretic	JJ	JJ	_	35	amod	_	_
33	mobility	mobility	NN	NN	_	35	compound	_	_
34	shift	shift	NN	NN	_	35	compound	_	_
35	assays	assay	NNS	NNS	_	27	conj	_	_
36	,	,	,	,	_	24	punct	_	_
37	respectively	respectively	RB	RB	_	24	advmod	_	_
38	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	concentration	concentration	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	c-fos	c-fos	NN	NN	_	10	compound	_	_
5	,	,	,	,	_	10	punct	_	_
6	c-jun	c-jun	NN	NN	_	10	dep	_	_
7	,	,	,	,	_	10	punct	_	_
8	c-myc	c-myc	NN	NN	_	10	dep	_	_
9	,	,	,	,	_	10	punct	_	_
10	junB	junb	NN	NN	_	2	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	fra-1	fra-1	NN	NN	_	14	compound	_	_
14	mRNAs	mrna	NNS	NNS	_	10	conj	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	increased	increase	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	21	case	_	_
18	activated	activate	VBN	VBN	_	21	amod	_	_
19	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
20	blood	blood	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
22	incubated	incubate	VBN	VBN	_	21	acl	_	_
23	with	with	IN	IN	_	24	case	_	_
24	ciprofloxacin	ciprofloxacin	NN	NN	_	22	nmod	_	_
25	compared	compare	VBN	VBN	_	27	case	_	_
26	to	to	TO	TO	_	27	case	_	_
27	that	that	DT	DT	_	16	advcl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	untreated	untreated	JJ	JJ	_	30	amod	_	_
30	controls	control	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	Ciprofloxacin	ciprofloxacin	NN	NN	_	2	nsubj	_	_
2	increased	increase	VBD	VBD	_	0	root	_	_
3	CAT	cat	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	stimulated	stimulate	VBN	VBN	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
8	transfected	transfect	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	10	case	_	_
10	plasmids	plasmid	NNS	NNS	_	8	nmod	_	_
11	containing	contain	VBG	VBG	_	10	acl	_	_
12	either	either	CC	CC	_	14	cc:preconj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	IL-2	il-2	NN	NN	_	11	dobj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	metallothionein	metallothionein	NN	NN	_	17	compound	_	_
17	enhancer	enhancer	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	among	among	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	12	nmod	_	_
7	tested	test	VBN	VBN	_	6	acl	_	_
8	,	,	,	,	_	12	punct	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	increased	increase	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	18	case	_	_
14	stimulated	stimulate	VBN	VBN	_	18	amod	_	_
15	purified	purify	VBN	VBN	_	18	amod	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	helper	helper	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
19	incubated	incubate	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	ciprofloxacin	ciprofloxacin	NN	NN	_	19	nmod	_	_
22	compared	compare	VBN	VBN	_	25	case	_	_
23	to	to	TO	TO	_	25	case	_	_
24	drug-free	drug-free	JJ	JJ	_	25	amod	_	_
25	controls	control	NNS	NNS	_	12	advcl	_	_
26	.	.	.	.	_	12	punct	_	_

1	Taken	take	VBN	VBN	_	5	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	ciprofloxacin	ciprofloxacin	NN	NN	_	5	nsubj	_	_
5	increased	increase	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	immediate-early	immediate-early	JJ	JJ	_	10	amod	_	_
10	transcripts	transcript	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	enhanced	enhance	VBD	VBD	_	5	conj	_	_
13	IL-2	il-2	NN	NN	_	17	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	metallothionein	metallothionein	NN	NN	_	13	conj	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	induction	induction	NN	NN	_	12	dobj	_	_
18	,	,	,	,	_	5	punct	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	upregulated	upregulate	VBD	VBD	_	5	conj	_	_
21	AP-1	ap-1	NN	NN	_	22	compound	_	_
22	concentrations	concentration	NNS	NNS	_	20	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	primary	primary	JJ	JJ	_	25	amod	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
26	,	,	,	,	_	5	punct	_	_
27	reflecting	reflect	VBG	VBG	_	5	xcomp	_	_
28	a	a	DT	DT	_	29	det	_	_
29	program	program	NN	NN	_	27	dobj	_	_
30	commonly	commonly	RB	RB	_	31	advmod	_	_
31	observed	observe	VBN	VBN	_	29	acl	_	_
32	in	in	IN	IN	_	35	case	_	_
33	mammalian	mammalian	JJ	JJ	_	35	amod	_	_
34	stress	stress	NN	NN	_	35	compound	_	_
35	responses	response	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Recognition	recognition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	herpes	herpes	NN	NN	_	9	compound	_	_
4	simplex	simplex	NN	NN	_	9	compound	_	_
5	virus	virus	NN	NN	_	9	compound	_	_
6	type	type	NN	NN	_	9	compound	_	_
7	2	2	CD	CD	_	9	nummod	_	_
8	tegument	tegument	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	1	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	CD4	cd4	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	1	nmod	_	_
14	infiltrating	infiltrate	VBG	VBG	_	13	acl	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	genital	genital	JJ	JJ	_	18	amod	_	_
17	herpes	herpes	NN	NN	_	18	compound	_	_
18	lesions	lesion	NNS	NNS	_	14	dobj	_	_
19	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	local	local	JJ	JJ	_	5	amod	_	_
3	cellular	cellular	JJ	JJ	_	5	amod	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	14	nsubj	_	_
6	to	to	TO	TO	_	9	case	_	_
7	herpes	herpes	NN	NN	_	9	compound	_	_
8	simplex	simplex	NN	NN	_	9	compound	_	_
9	virus	virus	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HSV	hsv	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	important	important	JJ	JJ	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	control	control	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	recurrent	recurrent	JJ	JJ	_	21	amod	_	_
20	HSV	hsv	NN	NN	_	21	compound	_	_
21	infection	infection	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	antiviral	antiviral	JJ	JJ	_	3	amod	_	_
3	functions	function	NNS	NNS	_	10	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	infiltrating	infiltrate	VBG	VBG	_	8	amod	_	_
6	CD4-bearing	cd4-bearing	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	include	include	VBP	VBP	_	0	root	_	_
11	cytotoxicity	cytotoxicity	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	inhibition	inhibition	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	viral	viral	JJ	JJ	_	16	amod	_	_
16	growth	growth	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	lymphokine	lymphokine	NN	NN	_	19	compound	_	_
19	secretion	secretion	NN	NN	_	11	conj	_	_
20	,	,	,	,	_	11	punct	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	support	support	NN	NN	_	11	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	humoral	humoral	JJ	JJ	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	CD8	cd8	NN	NN	_	24	conj	_	_
27	responses	response	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	antigens	antigen	NNS	NNS	_	16	nsubj	_	_
3	recognized	recognize	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	10	mark	_	_
5	many	many	JJ	JJ	_	9	amod	_	_
6	HSV-specific	hsv-specific	JJ	JJ	_	9	amod	_	_
7	CD4	cd4	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	10	nsubj	_	_
10	localizing	localize	VBG	VBG	_	3	advcl	_	_
11	to	to	TO	TO	_	14	case	_	_
12	genital	genital	JJ	JJ	_	14	amod	_	_
13	HSV-2	hsv-2	NN	NN	_	14	compound	_	_
14	lesions	lesion	NNS	NNS	_	10	nmod	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	unknown	unknown	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	17	nsubjpass	_	_
3	recognizing	recognize	VBG	VBG	_	2	acl	_	_
4	antigens	antigen	NNS	NNS	_	3	dobj	_	_
5	encoded	encode	VBN	VBN	_	4	acl	_	_
6	within	within	IN	IN	_	8	case	_	_
7	map	map	NN	NN	_	8	compound	_	_
8	units	unit	NNS	NNS	_	5	nmod	_	_
9	0.67	0.67	CD	CD	_	8	dep	_	_
10	to	to	TO	TO	_	9	dep	_	_
11	0.73	0.73	CD	CD	_	9	dep	_	_
12	of	of	IN	IN	_	14	case	_	_
13	HSV	hsv	NN	NN	_	14	compound	_	_
14	DNA	dna	NN	NN	_	8	nmod	_	_
15	are	be	VBP	VBP	_	17	auxpass	_	_
16	frequently	frequently	RB	RB	_	17	advmod	_	_
17	recovered	recover	VBN	VBN	_	0	root	_	_
18	from	from	IN	IN	_	20	case	_	_
19	herpetic	herpetic	JJ	JJ	_	20	amod	_	_
20	lesions	lesion	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	cloning	cloning	NN	NN	_	9	nsubj	_	_
3	with	with	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	region	region	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	DNA	dna	NN	NN	_	5	nmod	_	_
8	now	now	RB	RB	_	9	advmod	_	_
9	shows	show	VBZ	VBZ	_	0	root	_	_
10	that	that	IN	IN	_	30	mark	_	_
11	tegument	tegument	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	VP22	vp22	NN	NN	_	30	nsubj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	dUTPase	dutpase	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	encoded	encode	VBN	VBN	_	13	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	genes	gene	NNS	NNS	_	19	nmod	_	_
22	UL49	ul49	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	UL50	ul50	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	19	punct	_	_
26	respectively	respectively	RB	RB	_	19	advmod	_	_
27	,	,	,	,	_	13	punct	_	_
28	are	be	VBP	VBP	_	30	cop	_	_
29	T-cell	t-cell	NN	NN	_	30	compound	_	_
30	antigens	antigen	NNS	NNS	_	9	ccomp	_	_
31	.	.	.	.	_	9	punct	_	_

1	Separate	separate	JJ	JJ	_	2	amod	_	_
2	epitopes	epitope	NNS	NNS	_	6	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	VP22	vp22	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	defined	define	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	clones	clone	NNS	NNS	_	6	nmod	_	_
10	from	from	IN	IN	_	11	case	_	_
11	each	each	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	three	three	CD	CD	_	14	nummod	_	_
14	patients	patient	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Reactivity	reactivity	NN	NN	_	10	nsubjpass	_	_
2	with	with	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tegument	tegument	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	encoded	encode	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	UL21	ul21	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	additional	additional	JJ	JJ	_	14	amod	_	_
14	patient	patient	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	epitopes	epitope	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	VP16	vp16	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	tegument	tegument	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	7	appos	_	_
12	associated	associate	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	VP22	vp22	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Some	some	DT	DT	_	5	det	_	_
2	tegument-specific	tegument-specific	JJ	JJ	_	5	amod	_	_
3	CD4	cd4	NN	NN	_	5	compound	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	6	nsubj	_	_
6	exhibited	exhibit	VBD	VBD	_	0	root	_	_
7	cytotoxic	cytotoxic	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	against	against	IN	IN	_	11	case	_	_
10	HSV-infected	hsv-infected	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	herpes	herpes	NN	NN	_	8	compound	_	_
6	simplex	simplex	NN	NN	_	8	compound	_	_
7	tegument	tegument	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	processed	process	VBN	VBN	_	3	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	antigen	antigen	NN	NN	_	13	compound	_	_
13	presentation	presentation	NN	NN	_	10	nmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	10	advmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	are	be	VBP	VBP	_	20	cop	_	_
18	possible	possible	JJ	JJ	_	20	amod	_	_
19	candidate	candidate	NN	NN	_	20	compound	_	_
20	compounds	compound	NNS	NNS	_	10	conj	_	_
21	for	for	IN	IN	_	24	case	_	_
22	herpes	herpes	NN	NN	_	24	compound	_	_
23	simplex	simplex	NN	NN	_	24	compound	_	_
24	vaccines	vaccine	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	15-lipoxygenase	15-lipoxygenase	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	0	root	_	_
5	:	:	:	:	_	4	punct	_	_
6	analysis	analysis	NN	NN	_	4	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	identification	identification	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	6	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	IL-13-induced	il-13-induced	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	study	study	VB	VB	_	14	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	control	control	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	15-LO	15-lo	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	cloned	clone	VBN	VBN	_	0	root	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	sequenced	sequence	VBD	VBD	_	14	conj	_	_
17	the	the	DT	DT	_	21	det	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	15-LO	15-lo	NN	NN	_	21	compound	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	14	dobj	_	_
22	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	15-LO	15-lo	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	CpG	cpg	NN	NN	_	9	compound	_	_
9	island	island	NN	NN	_	5	nmod	_	_
10	at	at	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	5'-end	5'-end	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	gene	gene	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	sequence	sequence	NN	NN	_	19	compound	_	_
19	analysis	analysis	NN	NN	_	20	nsubj	_	_
20	reveals	reveal	VBZ	VBZ	_	5	conj	_	_
21	putative	putative	JJ	JJ	_	22	amod	_	_
22	Sp1	sp1	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Ap2	ap2	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	site/s	site/s	NNS	NNS	_	22	conj	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	absence	absence	NN	NN	_	22	conj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	TATA	tata	NN	NN	_	33	compound	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	CAAT	caat	NN	NN	_	30	conj	_	_
33	motifs	motif	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Transcription	transcription	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	initiated	initiate	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	7	case	_	_
5	one	one	CD	CD	_	7	nummod	_	_
6	major	major	JJ	JJ	_	7	amod	_	_
7	site	site	NN	NN	_	3	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	7	advcl	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	constructs	construct	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	defined	define	VBN	VBN	_	0	root	_	_
8	an	a	DT	DT	_	11	det	_	_
9	active	active	JJ	JJ	_	11	amod	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	1056	1056	CD	CD	_	11	nmod	_	_
14	bp	bp	NN	NN	_	13	dep	_	_
15	.	.	.	.	_	7	punct	_	_

1	Gel-shift	gel-shift	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
6	factor	factor	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	22	nsubj	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	induced	induce	VBN	VBN	_	8	acl	_	_
11	only	only	RB	RB	_	16	advmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	response	response	NN	NN	_	16	dep	_	_
14	to	to	TO	TO	_	16	case	_	_
15	IL-13	il-13	NN	NN	_	16	compound	_	_
16	treatment	treatment	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
20	blood	blood	NN	NN	_	21	compound	_	_
21	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
22	bind	bind	VBP	VBP	_	3	ccomp	_	_
23	to	to	TO	TO	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	15-LO	15-lo	NN	NN	_	27	compound	_	_
26	promoter	promoter	NN	NN	_	27	compound	_	_
27	DNA	dna	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	regions	region	NNS	NNS	_	23	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	DP1	dp1	NN	NN	_	2	appos	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	-140	-140	CD	CD	_	9	nummod	_	_
7	to	to	TO	TO	_	9	dep	_	_
8	-92	-92	CD	CD	_	9	nummod	_	_
9	bp	bp	NN	NN	_	4	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	DP2	dp2	NN	NN	_	4	conj	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	-353	-353	CD	CD	_	17	nummod	_	_
15	to	to	TO	TO	_	17	dep	_	_
16	-304	-304	CD	CD	_	17	nummod	_	_
17	bp	bp	NN	NN	_	12	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	4	nmod	_	_
22	were	be	VBD	VBD	_	23	cop	_	_
23	essential	essential	JJ	JJ	_	0	root	_	_
24	for	for	IN	IN	_	25	case	_	_
25	transcription	transcription	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	HeLa	hela	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	peripheral	peripheral	JJ	JJ	_	32	amod	_	_
32	monocytes	monocyte	NNS	NNS	_	28	conj	_	_
33	.	.	.	.	_	23	punct	_	_

1	Hela	hela	NN	NN	_	3	compound	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	extracts	extract	NNS	NNS	_	4	nsubj	_	_
4	contained	contain	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	10	det	_	_
6	specific	specific	JJ	JJ	_	10	amod	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	s	s	NNS	NNS	_	4	dobj	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	binding	bind	VBG	VBG	_	10	acl	_	_
13	to	to	TO	TO	_	16	case	_	_
14	15-LO	15-lo	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	DNA	dna	NN	NN	_	12	nmod	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	distinct	distinct	JJ	JJ	_	16	acl:relcl	_	_
20	from	from	IN	IN	_	21	case	_	_
21	those	those	DT	DT	_	19	nmod	_	_
22	derived	derive	VBN	VBN	_	21	acl	_	_
23	from	from	IN	IN	_	29	case	_	_
24	IL-13-treated	il-13-treated	JJ	JJ	_	29	amod	_	_
25	human	human	JJ	JJ	_	29	amod	_	_
26	peripheral	peripheral	JJ	JJ	_	29	amod	_	_
27	monocyte	monocyte	NN	NN	_	29	compound	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	extracts	extract	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	fluorescent	fluorescent	JJ	JJ	_	7	amod	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	situ	situ	FW	FW	_	5	dep	_	_
7	hybridization	hybridization	NN	NN	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	FISH	fish	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	results	result	VBZ	VBZ	_	7	dep	_	_
12	refined	refine	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	previous	previous	JJ	JJ	_	15	amod	_	_
15	localization	localization	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	15-LO	15-lo	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	chromosome	chromosome	NN	NN	_	21	compound	_	_
21	17p13.3	17p13.3	NN	NN	_	12	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Lack	lack	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T-cell-mediated	t-cell-mediated	JJ	JJ	_	4	amod	_	_
4	recognition	recognition	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	fusion	fusion	NN	NN	_	8	compound	_	_
8	region	region	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	pml/RAR-alpha	pml/rar-alpha	NN	NN	_	13	compound	_	_
12	hybrid	hybrid	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	8	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	acute	acute	JJ	JJ	_	20	amod	_	_
18	promyelocytic	promyelocytic	JJ	JJ	_	20	amod	_	_
19	leukemia	leukemia	NN	NN	_	20	compound	_	_
20	patients	patient	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	it	it	PRP	PRP	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	30	mark	_	_
9	the	the	DT	DT	_	11	det	_	_
10	fusion	fusion	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	30	nsubjpass	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	pml/RAR-alpha	pml/rar-alpha	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	expressed	express	VBN	VBN	_	11	acl	_	_
18	by	by	IN	IN	_	25	case	_	_
19	acute	acute	JJ	JJ	_	21	amod	_	_
20	promyelocytic	promyelocytic	JJ	JJ	_	21	amod	_	_
21	leukemia	leukemia	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	APL	apl	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	cells	cell	NNS	NNS	_	17	nmod	_	_
26	,	,	,	,	_	11	punct	_	_
27	can	can	MD	MD	_	30	aux	_	_
28	be	be	VB	VB	_	30	auxpass	_	_
29	specifically	specifically	RB	RB	_	30	advmod	_	_
30	recognized	recognize	VBN	VBN	_	7	ccomp	_	_
31	in	in	FW	FW	_	32	compound	_	_
32	vitro	vitro	FW	FW	_	30	advmod	_	_
33	by	by	IN	IN	_	41	case	_	_
34	donor	donor	NN	NN	_	41	compound	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	D.	D.	NNP	NNP	_	37	compound	_	_
37	E.	E.	NNP	NNP	_	34	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	CD4	cd4	NN	NN	_	41	compound	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	30	nmod	_	_
42	in	in	IN	IN	_	48	case	_	_
43	a	a	DT	DT	_	48	det	_	_
44	HLA	hla	NN	NN	_	47	nmod:npmod	_	_
45	class	class	NN	NN	_	47	nmod:npmod	_	_
46	II	ii	CD	CD	_	47	compound	_	_
47	DR11-restricted	dr11-restricted	JJ	JJ	_	48	amod	_	_
48	fashion	fashion	NN	NN	_	30	nmod	_	_
49	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	2	dobj	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	recognition	recognition	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	several	several	JJ	JJ	_	12	amod	_	_
11	pml/RAR-alpha	pml/rar-alpha	NN	NN	_	12	compound	_	_
12	peptides	peptide	NNS	NNS	_	8	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	APL	apl	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	8	nmod	_	_
16	expressing	express	VBG	VBG	_	15	acl	_	_
17	HLA	hla	NN	NN	_	18	compound	_	_
18	DR11	dr11	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	immunization	immunization	NN	NN	_	33	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
7	blood	blood	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	four	four	CD	CD	_	11	nummod	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	remission	remission	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	S.R.	S.R.	NNP	NNP	_	11	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	F.R.	F.R.	NNP	NNP	_	15	appos	_	_
18	,	,	,	,	_	15	punct	_	_
19	M.M.	M.M.	NNP	NNP	_	15	appos	_	_
20	,	,	,	,	_	15	punct	_	_
21	P.	P.	NNP	NNP	_	22	compound	_	_
22	G.	G.	NNP	NNP	_	15	appos	_	_
23	)	)	-RRB-	-RRB-	_	15	punct	_	_
24	with	with	IN	IN	_	25	case	_	_
25	BCR1/25	bcr1/25	NN	NN	_	4	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	a	a	DT	DT	_	29	det	_	_
28	25-mer	25-mer	NN	NN	_	29	compound	_	_
29	pml/RAR-alpha	pml/rar-alpha	NN	NN	_	25	appos	_	_
30	,	,	,	,	_	25	punct	_	_
31	did	do	VBD	VBD	_	33	aux	_	_
32	not	not	RB	RB	_	33	neg	_	_
33	elicit	elicit	VB	VB	_	0	root	_	_
34	either	either	CC	CC	_	36	cc:preconj	_	_
35	a	a	DT	DT	_	36	det	_	_
36	polyclonal	polyclonal	JJ	JJ	_	33	dobj	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	a	a	DT	DT	_	39	det	_	_
39	clonal	clonal	JJ	JJ	_	36	conj	_	_
40	immune	immune	JJ	JJ	_	41	amod	_	_
41	response	response	NN	NN	_	36	dep	_	_
42	specific	specific	JJ	JJ	_	36	amod	_	_
43	to	to	TO	TO	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	peptide	peptide	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	33	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	then	then	RB	RB	_	3	advmod	_	_
3	generated	generate	VBD	VBD	_	0	root	_	_
4	new	new	JJ	JJ	_	9	amod	_	_
5	donor	donor	NN	NN	_	9	compound	_	_
6	anti-pml/RAR-alpha	anti-pml/rar-alpha	JJ	JJ	_	9	amod	_	_
7	CD4(+)	cd4(+)	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	clones	clone	NNS	NNS	_	3	dobj	_	_
10	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	clones	clone	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	tested	test	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	their	they	PRP$	PRP$	_	7	nmod:poss	_	_
7	recognition	recognition	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	BCR1/25	bcr1/25	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	clone	clone	NN	NN	_	13	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	C3/5	c3/5	NN	NN	_	2	dep	_	_
5	,	,	,	,	_	4	punct	_	_
6	CD3(+)	cd3(+)	JJ	JJ	_	4	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	CD4(+)	cd4(+)	JJ	JJ	_	6	dep	_	_
9	,	,	,	,	_	6	punct	_	_
10	CD8(-)	cd8(-)	JJ	JJ	_	6	dep	_	_
11	)	)	-RRB-	-RRB-	_	4	punct	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	selected	select	VBN	VBN	_	0	root	_	_
14	for	for	IN	IN	_	16	case	_	_
15	further	further	JJ	JJ	_	16	amod	_	_
16	analysis	analysis	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Clone	clone	NN	NN	_	2	compound	_	_
2	C3/5	c3/5	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	proliferation	proliferation	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	cytotoxicity	cytotoxicity	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	cytokine	cytokine	NN	NN	_	21	compound	_	_
11	(	(	-LRB-	-LRB-	_	19	punct	_	_
12	tumor	tumor	NN	NN	_	15	compound	_	_
13	necrosis	necrosis	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	19	compound	_	_
16	,	,	,	,	_	15	punct	_	_
17	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	18	amod	_	_
18	colony-stimulating	colony-stimulating	JJ	JJ	_	15	amod	_	_
19	factor	factor	NN	NN	_	10	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	production	production	NN	NN	_	5	conj	_	_
22	when	when	WRB	WRB	_	23	advmod	_	_
23	challenged	challenge	VBN	VBN	_	3	advcl	_	_
24	with	with	IN	IN	_	28	case	_	_
25	autologous	autologous	JJ	JJ	_	28	amod	_	_
26	lymphoblastic	lymphoblastic	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	23	nmod	_	_
29	pulsed	pulse	VBN	VBN	_	28	acl	_	_
30	with	with	IN	IN	_	32	case	_	_
31	peptide	peptide	NN	NN	_	32	compound	_	_
32	BCR1/25	bcr1/25	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	C3/5	c3/5	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	developed	develop	VBD	VBD	_	0	root	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	proliferation	proliferation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cytotoxicity	cytotoxicity	NN	NN	_	5	conj	_	_
8	when	when	WRB	WRB	_	9	advmod	_	_
9	challenged	challenge	VBN	VBN	_	3	advcl	_	_
10	with	with	IN	IN	_	14	case	_	_
11	peptide-pulsed	peptide-pulsed	JJ	JJ	_	14	amod	_	_
12	lymphoblastic	lymphoblastic	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	14	conj	_	_
19	from	from	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	four	four	CD	CD	_	24	nummod	_	_
22	DR11(+)	dr11(+)	JJ	JJ	_	24	amod	_	_
23	APL	apl	NN	NN	_	24	compound	_	_
24	patients	patient	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	APL	apl	NN	NN	_	2	compound	_	_
2	blasts	blast	NNS	NNS	_	14	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	available	available	JJ	JJ	_	2	amod	_	_
5	only	only	RB	RB	_	7	advmod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	F.R.	F.R.	NNP	NNP	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	P.G.	P.G.	NNP	NNP	_	8	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	lysed	lyse	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	C3/5	c3/5	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	unable	unable	JJ	JJ	_	14	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	present	present	VB	VB	_	19	xcomp	_	_
22	peptide	peptide	NN	NN	_	23	compound	_	_
23	BCR1/25	bcr1/25	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	14	punct	_	_

1	Incubation	incubation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	APL	apl	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
7	failed	fail	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	7	xcomp	_	_
10	HLA	hla	NN	NN	_	13	compound	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	molecules	molecule	NNS	NNS	_	9	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	recognition	recognition	NN	NN	_	13	conj	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	C3/5	c3/5	NN	NN	_	19	compound	_	_
19	clone	clone	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	APL	apl	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	6	nsubj	_	_
4	do	do	VBP	VBP	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	express	express	VB	VB	_	13	advcl	_	_
7	HLA	hla	NN	NN	_	10	compound	_	_
8	class	class	NN	NN	_	10	compound	_	_
9	II	ii	CD	CD	_	10	nummod	_	_
10	molecules	molecule	NNS	NNS	_	6	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	tested	test	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	two	two	CD	CD	_	16	nummod	_	_
16	donors	donor	NNS	NNS	_	13	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	D.E.	D.E.	NNP	NNP	_	16	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	C.H.R.	C.H.R.	NNP	NNP	_	18	conj	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	in	in	IN	IN	_	24	case	_	_
24	patients	patient	NNS	NNS	_	16	conj	_	_
25	S.R.	s.r.	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	P.G.	p.g.	NN	NN	_	25	conj	_	_
28	whether	whether	CC	CC	_	38	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	use	use	NN	NN	_	38	nsubj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	9-mer	9-mer	NN	NN	_	33	compound	_	_
33	peptides	peptide	NNS	NNS	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	BCR1/9	bcr1/9	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	would	would	MD	MD	_	38	aux	_	_
38	generate	generate	VB	VB	_	13	ccomp	_	_
39	a	a	DT	DT	_	43	det	_	_
40	CD8/HLA	cd8/hla	NN	NN	_	42	nmod:npmod	_	_
41	class	class	NN	NN	_	42	nmod:npmod	_	_
42	I-restricted	i-restricted	JJ	JJ	_	43	amod	_	_
43	response	response	NN	NN	_	38	dobj	_	_
44	.	.	.	.	_	13	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	peptide-specific	peptide-specific	JJ	JJ	_	3	amod	_	_
3	T-cell	t-cell	NN	NN	_	9	nsubjpass	_	_
4	line	line	NN	NN	_	3	dep	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	clone	clone	NN	NN	_	4	conj	_	_
7	could	could	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	generated	generate	VBN	VBN	_	0	root	_	_
10	from	from	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	donors	donor	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	patients	patient	NNS	NNS	_	12	conj	_	_
15	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	discussed	discuss	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	relation	relation	NN	NN	_	10	dep	_	_
7	to	to	TO	TO	_	10	case	_	_
8	possible	possible	JJ	JJ	_	10	amod	_	_
9	therapeutic	therapeutic	JJ	JJ	_	10	amod	_	_
10	approaches	approach	NNS	NNS	_	4	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	immunotherapy	immunotherapy	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	APL	apl	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

