1	Generation	generation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	CD1+RelB+	cd1+relb+	JJ	JJ	_	5	amod	_	_
4	dendritic	dendritic	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	tartrate-resistant	tartrate-resistant	JJ	JJ	_	9	amod	_	_
8	acid	acid	NN	NN	_	9	nmod:npmod	_	_
9	phosphatase-positive	phosphatase-positive	JJ	JJ	_	13	amod	_	_
10	osteoclast-like	osteoclast-like	JJ	JJ	_	13	amod	_	_
11	multinucleated	multinucleated	JJ	JJ	_	13	amod	_	_
12	giant	giant	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	5	conj	_	_
14	from	from	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	7	amod	_	_
6	colony-stimulating	colony-stimulating	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	18	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	GM-CSF	gm-csf	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	macrophage	macrophage	NN	NN	_	14	compound	_	_
13	colony-stimulating	colony-stimulating	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	7	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	M-CSF	m-csf	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	stimulate	stimulate	VBP	VBP	_	3	ccomp	_	_
19	the	the	DT	DT	_	20	det	_	_
20	differentiation	differentiation	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	monocytes	monocyte	NNS	NNS	_	20	nmod	_	_
24	into	into	IN	IN	_	28	case	_	_
25	two	two	CD	CD	_	28	nummod	_	_
26	phenotypically	phenotypically	RB	RB	_	27	advmod	_	_
27	distinct	distinct	JJ	JJ	_	28	amod	_	_
28	types	type	NNS	NNS	_	20	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	macrophages	macrophage	NNS	NNS	_	28	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	in	in	FW	FW	_	4	compound	_	_
4	vivo	vivo	FW	FW	_	15	advmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	only	only	RB	RB	_	8	cc:preconj	_	_
8	CSF	csf	NN	NN	_	15	nsubjpass	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	also	also	RB	RB	_	13	advmod	_	_
11	many	many	JJ	JJ	_	13	amod	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	cytokines	cytokine	NNS	NNS	_	8	conj	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	produced	produce	VBN	VBN	_	0	root	_	_
16	under	under	IN	IN	_	18	case	_	_
17	various	various	JJ	JJ	_	18	amod	_	_
18	conditions	condition	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	Those	those	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	modulate	modulate	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	differentiation	differentiation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	CSFs	csf	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	CD14+	cd14+	JJ	JJ	_	12	amod	_	_
10	adherent	adherent	JJ	JJ	_	12	amod	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	differentiate	differentiate	VB	VB	_	7	ccomp	_	_
15	into	into	IN	IN	_	18	case	_	_
16	CD1+relB+	cd1+relb+	JJ	JJ	_	18	amod	_	_
17	dendritic	dendritic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	DC	dc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	by	by	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	combination	combination	NN	NN	_	14	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	GM-CSF	gm-csf	NN	NN	_	24	nmod	_	_
27	plus	plus	CC	CC	_	26	cc	_	_
28	interleukin-4	interleukin-4	NN	NN	_	26	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	IL-4	il-4	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	14	cc	_	_
33	that	that	IN	IN	_	35	mark	_	_
34	they	they	PRP	PRP	_	35	nsubj	_	_
35	differentiate	differentiate	VBP	VBP	_	14	conj	_	_
36	into	into	IN	IN	_	47	case	_	_
37	tartrate-resistant	tartrate-resistant	JJ	JJ	_	43	amod	_	_
38	acid	acid	NN	NN	_	43	nmod:npmod	_	_
39	phosphatase	phosphatase	NN	NN	_	43	nmod:npmod	_	_
40	(	(	-LRB-	-LRB-	_	43	punct	_	_
41	TRAP	trap	NN	NN	_	43	nmod:npmod	_	_
42	)	)	-RRB-	-RRB-	_	43	punct	_	_
43	-positive	-positive	JJ	JJ	_	47	amod	_	_
44	osteoclast-like	osteoclast-like	JJ	JJ	_	47	amod	_	_
45	multinucleated	multinucleated	JJ	JJ	_	47	amod	_	_
46	giant	giant	JJ	JJ	_	47	amod	_	_
47	cells	cell	NNS	NNS	_	35	nmod	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	MGC	mgc	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	by	by	IN	IN	_	53	case	_	_
52	the	the	DT	DT	_	53	det	_	_
53	combination	combination	NN	NN	_	35	nmod	_	_
54	of	of	IN	IN	_	55	case	_	_
55	M-CSF	m-csf	NN	NN	_	53	nmod	_	_
56	plus	plus	CC	CC	_	55	cc	_	_
57	IL-4	il-4	NN	NN	_	55	conj	_	_
58	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	monocyte-derived	monocyte-derived	JJ	JJ	_	5	amod	_	_
5	DC	dc	NN	NN	_	10	nsubj	_	_
6	were	be	VBD	VBD	_	10	cop	_	_
7	not	not	RB	RB	_	10	neg	_	_
8	terminally	terminally	RB	RB	_	9	advmod	_	_
9	differentiated	differentiate	VBN	VBN	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	0	root	_	_
11	;	;	:	:	_	10	punct	_	_
12	they	they	PRP	PRP	_	15	nsubj	_	_
13	could	could	MD	MD	_	15	aux	_	_
14	still	still	RB	RB	_	15	advmod	_	_
15	convert	convert	VB	VB	_	10	parataxis	_	_
16	to	to	TO	TO	_	17	case	_	_
17	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	response	response	NN	NN	_	21	dep	_	_
20	to	to	TO	TO	_	21	case	_	_
21	M-CSF	m-csf	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Tumor	tumor	NN	NN	_	3	compound	_	_
2	necrosis	necrosis	NN	NN	_	3	compound	_	_
3	factor-alpha	factor-alpha	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TNF-alpha	tnf-alpha	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	stimulated	stimulate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	terminal	terminal	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	DC	dc	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	downregulating	downregulate	VBG	VBG	_	7	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	M-CSF	m-csf	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	cfms	cfms	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	21	appos	_	_
25	,	,	,	,	_	15	punct	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	aborting	abort	VBG	VBG	_	15	conj	_	_
28	the	the	DT	DT	_	29	det	_	_
29	potential	potential	NN	NN	_	27	dobj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	convert	convert	VB	VB	_	29	acl	_	_
32	to	to	TO	TO	_	33	case	_	_
33	macrophages	macrophage	NNS	NNS	_	31	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	contrast	contrast	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	case	_	_
4	IL-4	il-4	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	interferon-gamma	interferon-gamma	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	no	no	DT	DT	_	13	neg	_	_
12	demonstrable	demonstrable	JJ	JJ	_	13	amod	_	_
13	effect	effect	NN	NN	_	10	dobj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	differentiation	differentiation	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Rather	rather	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	4	nsubj	_	_
4	antagonized	antagonize	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-4	il-4	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	suppressed	suppress	VBD	VBD	_	4	conj	_	_
11	the	the	DT	DT	_	15	det	_	_
12	DC	dc	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	MGC	mgc	NN	NN	_	12	conj	_	_
15	formation	formation	NN	NN	_	10	dobj	_	_
16	induced	induce	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	GM-CSF	gm-csf	NN	NN	_	16	nmod	_	_
19	+	+	CC	CC	_	18	cc	_	_
20	IL-4	il-4	NN	NN	_	18	conj	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	M-CSF	m-csf	NN	NN	_	18	conj	_	_
23	+	+	CC	CC	_	22	cc	_	_
24	IL-4	il-4	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	18	punct	_	_
26	respectively	respectively	RB	RB	_	18	advmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	provide	provide	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	new	new	JJ	JJ	_	9	amod	_	_
9	aspect	aspect	NN	NN	_	6	dobj	_	_
10	to	to	TO	TO	_	12	case	_	_
11	our	we	PRP$	PRP$	_	12	nmod:poss	_	_
12	knowledge	knowledge	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	monocyte	monocyte	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	provide	provide	VBP	VBP	_	6	conj	_	_
18	evidence	evidence	NN	NN	_	17	dobj	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	23	nsubj	_	_
22	are	be	VBP	VBP	_	23	cop	_	_
23	flexible	flexible	JJ	JJ	_	18	ccomp	_	_
24	in	in	IN	IN	_	27	case	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	differentiation	differentiation	NN	NN	_	27	compound	_	_
27	potential	potential	NN	NN	_	23	nmod	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	precursors	precursor	NNS	NNS	_	23	conj	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	only	only	RB	RB	_	34	cc:preconj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	macrophages	macrophage	NNS	NNS	_	30	nmod	_	_
35	but	but	CC	CC	_	34	cc	_	_
36	also	also	RB	RB	_	38	advmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	CD1+relB+DC	cd1+relb+dc	NN	NN	_	34	conj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	TRAP-positive	trap-positive	JJ	JJ	_	41	amod	_	_
41	MGC	mgc	NN	NN	_	38	conj	_	_
42	.	.	.	.	_	6	punct	_	_

1	Such	such	PDT	PDT	_	4	det:predet	_	_
2	a	a	DT	DT	_	4	det	_	_
3	diverse	diverse	JJ	JJ	_	4	amod	_	_
4	pathway	pathway	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	monocyte	monocyte	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	4	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	constitute	constitute	VB	VB	_	0	root	_	_
10	one	one	CD	CD	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	basic	basic	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	regulation	regulation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	4	compound	_	_
4	rise	rise	NN	NN	_	1	nmod	_	_
5	activated	activate	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	doxepin-sensitive	doxepin-sensitive	JJ	JJ	_	9	amod	_	_
8	H1-histamine	h1-histamine	JJ	JJ	_	9	amod	_	_
9	receptors	receptor	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Jurkat	jurkat	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	cloned	clone	VBN	VBN	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	12	appos	_	_
18	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	clarify	clarify	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	histamine	histamine	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	transmembrane	transmembrane	JJ	JJ	_	11	amod	_	_
11	mechanism	mechanism	NN	NN	_	7	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	investigated	investigate	VBD	VBD	_	2	parataxis	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effects	effect	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	agonists	agonist	NNS	NNS	_	20	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	antagonists	antagonist	NNS	NNS	_	22	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	histamine	histamine	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	28	compound	_	_
28	subtypes	subtype	NNS	NNS	_	22	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	bacterial	bacterial	JJ	JJ	_	31	amod	_	_
31	toxins	toxin	NNS	NNS	_	28	conj	_	_
32	on	on	IN	IN	_	34	case	_	_
33	intracellular	intracellular	JJ	JJ	_	34	amod	_	_
34	concentration	concentration	NN	NN	_	20	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	Ca2+	ca2+	NN	NN	_	34	nmod	_	_
37	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	34	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	,	,	,	,	_	34	punct	_	_
40	-LSB-3H-RSB-pyrilamine	-lsb-3h-rsb-pyrilamine	NN	NN	_	41	compound	_	_
41	binding	binding	NN	NN	_	34	conj	_	_
42	and	and	CC	CC	_	34	cc	_	_
43	c-fos	c-fos	NN	NN	_	44	compound	_	_
44	mRNA	mrna	NN	NN	_	45	compound	_	_
45	expression	expression	NN	NN	_	34	conj	_	_
46	in	in	IN	IN	_	48	case	_	_
47	Jurkat	jurkat	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	34	nmod	_	_
49	,	,	,	,	_	48	punct	_	_
50	cloned	clone	VBN	VBN	_	53	amod	_	_
51	human	human	JJ	JJ	_	53	amod	_	_
52	T	t	NN	NN	_	53	compound	_	_
53	lymphocytes	lymphocyte	NNS	NNS	_	48	appos	_	_
54	.	.	.	.	_	2	punct	_	_

1	H1-agonists	h1-agonist	NNS	NNS	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	histamine	histamine	NN	NN	_	1	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	2-methylhistamine	2-methylhistamine	NN	NN	_	3	conj	_	_
6	)	)	-RRB-	-RRB-	_	3	punct	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	transient	transient	JJ	JJ	_	10	amod	_	_
10	rise	rise	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	-LSB-Ca2+-RSB-	-lsb-ca2+-rsb-	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	H1-antagonists	h1-antagonist	NNS	NNS	_	21	nsubj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	pyrilamine	pyrilamine	NN	NN	_	15	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	doxepin	doxepin	NN	NN	_	17	conj	_	_
20	)	)	-RRB-	-RRB-	_	17	punct	_	_
21	inhibited	inhibit	VBD	VBD	_	7	conj	_	_
22	the	the	DT	DT	_	25	det	_	_
23	histamine-induced	histamine-induced	JJ	JJ	_	25	amod	_	_
24	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	25	compound	_	_
25	rise	rise	NN	NN	_	21	dobj	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	potently	potently	RB	RB	_	21	advmod	_	_
28	than	than	IN	IN	_	30	mark	_	_
29	the	the	DT	DT	_	30	det	_	_
30	H2-antagonist	h2-antagonist	NN	NN	_	27	advcl	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	cimetidine	cimetidine	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	on	on	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	H3-antagonist	h3-antagonist	NN	NN	_	30	dep	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	impromidine	impromidine	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	7	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	parameters	parameter	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	-LSB-3H-RSB-pyrilamine	-lsb-3h-rsb-pyrilamine	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	Kd	kd	NN	NN	_	0	root	_	_
8	=	=	JJ	JJ	_	7	amod	_	_
9	5.53	5.53	CD	CD	_	10	nummod	_	_
10	nM	nm	NN	NN	_	8	dep	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	Bmax	bmax	NN	NN	_	7	conj	_	_
13	=	=	JJ	JJ	_	12	amod	_	_
14	2	2	CD	CD	_	13	dep	_	_
15	,	,	,	,	_	7	punct	_	_
16	647	647	CD	CD	_	17	nummod	_	_
17	sites/cell	sites/cell	NNS	NNS	_	7	appos	_	_
18	.	.	.	.	_	7	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	11	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	B.pertussis	b.pertussis	FW	FW	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	V.cholera.	v.cholera.	FW	FW	_	3	conj	_	_
6	or	or	CC	CC	_	3	cc	_	_
7	C.botulinum	c.botulinum	FW	FW	_	3	conj	_	_
8	toxin	toxin	NN	NN	_	3	dep	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	influence	influence	VB	VB	_	0	root	_	_
12	histamine-induced	histamine-induced	JJ	JJ	_	14	amod	_	_
13	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	14	compound	_	_
14	rise	rise	NN	NN	_	11	dobj	_	_
15	.	.	.	.	_	11	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	Blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	11	nsubj	_	_
4	using	use	VBG	VBG	_	3	acl	_	_
5	antibodies	antibody	NNS	NNS	_	4	dobj	_	_
6	against	against	IN	IN	_	7	case	_	_
7	subunits	subunit	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	GTP-binding	gtp-binding	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	indicated	indicate	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	15	mark	_	_
13	Gq/G11	gq/g11	NN	NN	_	15	nsubj	_	_
14	richly	richly	RB	RB	_	15	advmod	_	_
15	existed	exist	VBD	VBD	_	11	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	Jurkat	jurkat	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Histamine	histamine	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	immediate	immediate	JJ	JJ	_	9	amod	_	_
8	early	early	JJ	JJ	_	9	amod	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	c-fos	c-fos	NN	NN	_	9	dep	_	_
11	.	.	.	.	_	2	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	13	nsubj	_	_
2	with	with	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	C	c	NN	NN	_	7	compound	_	_
7	activator	activator	NN	NN	_	1	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	phorbol	phorbol	NN	NN	_	11	compound	_	_
10	12-myristate	12-myristate	NN	NN	_	11	compound	_	_
11	13-acetate	13-acetate	NN	NN	_	7	appos	_	_
12	,	,	,	,	_	1	punct	_	_
13	caused	cause	VBD	VBD	_	0	root	_	_
14	almost	almost	RB	RB	_	15	advmod	_	_
15	complete	complete	JJ	JJ	_	16	amod	_	_
16	inhibition	inhibition	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	histamine-induced	histamine-induced	JJ	JJ	_	20	amod	_	_
19	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	20	compound	_	_
20	rise	rise	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	but	but	CC	CC	_	13	cc	_	_
23	did	do	VBD	VBD	_	25	aux	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	do	do	VB	VB	_	13	conj	_	_
26	so	so	RB	RB	_	25	advmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	activators	activator	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	cAMP-	camp-	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	cGMP-dependent	cgmp-dependent	JJ	JJ	_	30	conj	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	kinases	kinase	NNS	NNS	_	30	dep	_	_
35	.	.	.	.	_	13	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	response	response	NN	NN	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	transactivators	transactivator	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	chronic	chronic	JJ	JJ	_	11	amod	_	_
10	rheumatoid	rheumatoid	JJ	JJ	_	11	amod	_	_
11	arthritis	arthritis	NN	NN	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Rheumatoid	rheumatoid	JJ	JJ	_	2	amod	_	_
2	arthritis	arthritis	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	multistep	multistep	JJ	JJ	_	6	amod	_	_
6	disorder	disorder	NN	NN	_	0	root	_	_
7	associated	associate	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	10	case	_	_
9	autoimmune	autoimmune	JJ	JJ	_	10	amod	_	_
10	features	feature	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	yet	yet	RB	RB	_	13	advmod	_	_
13	unknown	unknown	JJ	JJ	_	14	amod	_	_
14	etiology	etiology	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Implication	implication	NN	NN	_	17	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	viruses	virus	NNS	NNS	_	1	nmod	_	_
4	such	such	JJ	JJ	_	7	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EBV	ebv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	14	case	_	_
12	rheumatoid	rheumatoid	JJ	JJ	_	14	amod	_	_
13	arthritis	arthritis	NN	NN	_	14	compound	_	_
14	pathogenesis	pathogenesis	NN	NN	_	1	nmod	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	suspected	suspect	VBN	VBN	_	0	root	_	_
18	on	on	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	dep	_	_
20	basis	basis	NN	NN	_	24	dep	_	_
21	of	of	IN	IN	_	24	case	_	_
22	several	several	JJ	JJ	_	24	amod	_	_
23	indirect	indirect	JJ	JJ	_	24	amod	_	_
24	observations	observation	NNS	NNS	_	17	nmod	_	_
25	,	,	,	,	_	17	punct	_	_
26	but	but	CC	CC	_	17	cc	_	_
27	thus	thus	RB	RB	_	28	advmod	_	_
28	far	far	RB	RB	_	41	advmod	_	_
29	,	,	,	,	_	41	punct	_	_
30	a	a	DT	DT	_	32	det	_	_
31	direct	direct	JJ	JJ	_	32	amod	_	_
32	link	link	NN	NN	_	41	nsubjpass	_	_
33	between	between	IN	IN	_	34	case	_	_
34	EBV	ebv	NN	NN	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	rheumatoid	rheumatoid	JJ	JJ	_	37	amod	_	_
37	arthritis	arthritis	NN	NN	_	34	conj	_	_
38	has	have	VBZ	VBZ	_	41	aux	_	_
39	not	not	RB	RB	_	41	neg	_	_
40	been	be	VBN	VBN	_	41	auxpass	_	_
41	provided	provide	VBN	VBN	_	17	conj	_	_
42	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	large	large	JJ	JJ	_	7	amod	_	_
7	fraction	fraction	NN	NN	_	21	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	infiltrating	infiltrate	VBG	VBG	_	7	acl	_	_
12	affected	affect	VBN	VBN	_	13	amod	_	_
13	joints	joint	NNS	NNS	_	11	dobj	_	_
14	from	from	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	patient	patient	NN	NN	_	13	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	chronic	chronic	JJ	JJ	_	20	amod	_	_
19	rheumatoid	rheumatoid	JJ	JJ	_	20	amod	_	_
20	arthritis	arthritis	NN	NN	_	16	nmod	_	_
21	recognizes	recognize	VBZ	VBZ	_	3	ccomp	_	_
22	two	two	CD	CD	_	24	nummod	_	_
23	EBV	ebv	NN	NN	_	24	compound	_	_
24	transactivators	transactivator	NNS	NNS	_	21	dobj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	BZLF1	bzlf1	NN	NN	_	24	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	BMLF1	bmlf1	NN	NN	_	26	conj	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	in	in	IN	IN	_	35	case	_	_
31	a	a	DT	DT	_	35	det	_	_
32	major	major	JJ	JJ	_	34	amod	_	_
33	histocompatibility	histocompatibility	NN	NN	_	34	nmod:npmod	_	_
34	complex-restricted	complex-restricted	JJ	JJ	_	35	amod	_	_
35	fashion	fashion	NN	NN	_	21	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Responses	response	NNS	NNS	_	18	nsubj	_	_
2	to	to	TO	TO	_	5	case	_	_
3	these	these	DT	DT	_	5	det	_	_
4	EBV	ebv	NN	NN	_	5	compound	_	_
5	antigens	antigen	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	synovial	synovial	JJ	JJ	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
9	from	from	IN	IN	_	15	case	_	_
10	several	several	JJ	JJ	_	15	amod	_	_
11	other	other	JJ	JJ	_	15	amod	_	_
12	chronic	chronic	JJ	JJ	_	15	amod	_	_
13	rheumatoid	rheumatoid	JJ	JJ	_	15	amod	_	_
14	arthritis	arthritis	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	8	nmod	_	_
16	were	be	VBD	VBD	_	18	cop	_	_
17	readily	readily	RB	RB	_	18	advmod	_	_
18	detectable	detectable	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	direct	direct	JJ	JJ	_	7	amod	_	_
7	contribution	contribution	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	EBV	ebv	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	chronic	chronic	JJ	JJ	_	14	amod	_	_
12	rheumatoid	rheumatoid	JJ	JJ	_	14	amod	_	_
13	arthritis	arthritis	NN	NN	_	14	compound	_	_
14	pathogenesis	pathogenesis	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	time	time	NN	NN	_	3	nmod	_	_
8	the	the	DT	DT	_	9	det	_	_
9	occurrence	occurrence	NN	NN	_	3	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	responses	response	NNS	NNS	_	9	nmod	_	_
14	against	against	IN	IN	_	17	case	_	_
15	EBV	ebv	NN	NN	_	17	compound	_	_
16	transactivating	transactivate	VBG	VBG	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	might	might	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	central	central	JJ	JJ	_	9	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	control	control	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	virus	virus	NN	NN	_	28	compound	_	_
28	reactivation	reactivation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	localization	localization	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	11	case	_	_
5	p50	p50	NN	NN	_	11	compound	_	_
6	,	,	,	,	_	5	punct	_	_
7	p52	p52	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	RelB	relb	NN	NN	_	5	conj	_	_
11	proteins	protein	NNS	NNS	_	3	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	accessory	accessory	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	3	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	15	nmod	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	situ	situ	FW	FW	_	19	advmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	17	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	p50	p50	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	6	punct	_	_
8	p52	p52	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	p65	p65	NN	NN	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	c-Rel	c-rel	NN	NN	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	RelB	relb	NN	NN	_	6	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	constitute	constitute	VBP	VBP	_	0	root	_	_
18	a	a	DT	DT	_	19	det	_	_
19	family	family	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	involved	involve	VBN	VBN	_	19	acl	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	positive	positive	JJ	JJ	_	27	amod	_	_
27	regulation	regulation	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	a	a	DT	DT	_	30	det	_	_
30	variety	variety	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	genes	gene	NNS	NNS	_	30	nmod	_	_
33	during	during	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	immune	immune	JJ	JJ	_	36	amod	_	_
36	response	response	NN	NN	_	27	nmod	_	_
37	.	.	.	.	_	17	punct	_	_

1	Recently	recently	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	RelB	relb	NN	NN	_	10	compound	_	_
9	knockout	knockout	JJ	JJ	_	10	amod	_	_
10	mice	mouse	NNS	NNS	_	11	nsubj	_	_
11	have	have	VBP	VBP	_	6	ccomp	_	_
12	no	no	DT	DT	_	14	neg	_	_
13	dendritic	dendritic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	DC	dc	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	6	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	overexpression	overexpression	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p50	p50	NN	NN	_	2	nmod	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	described	describe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	follicular	follicular	JJ	JJ	_	11	amod	_	_
10	dendritic	dendritic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	FDC	fdc	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	constitutive	constitutive	JJ	JJ	_	5	amod	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	reported	report	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	mature	mature	JJ	JJ	_	11	amod	_	_
11	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	led	lead	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	2	nmod	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	some	some	DT	DT	_	16	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	7	nmod	_	_
13	were	be	VBD	VBD	_	16	cop	_	_
14	key	key	JJ	JJ	_	16	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	5	ccomp	_	_
17	in	in	IN	IN	_	18	case	_	_
18	functions	function	NNS	NNS	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	accessory	accessory	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	immune	immune	JJ	JJ	_	25	amod	_	_
25	response	response	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	situ	situ	FW	FW	_	4	advmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	localization	localization	NN	NN	_	4	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	accessory	accessory	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	immune	immune	JJ	JJ	_	20	amod	_	_
20	system	system	NN	NN	_	16	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	immunohistochemistry	immunohistochemistry	NN	NN	_	4	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	double	double	JJ	JJ	_	25	amod	_	_
25	labeling	labeling	NN	NN	_	22	conj	_	_
26	by	by	IN	IN	_	27	case	_	_
27	immunofluorescence	immunofluorescence	NN	NN	_	25	nmod	_	_
28	from	from	IN	IN	_	32	case	_	_
29	five	five	CD	CD	_	32	nummod	_	_
30	normal	normal	JJ	JJ	_	32	amod	_	_
31	human	human	JJ	JJ	_	32	amod	_	_
32	tonsils	tonsil	NNS	NNS	_	4	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	five	five	CD	CD	_	36	nummod	_	_
35	lymph	lymph	NN	NN	_	36	compound	_	_
36	nodes	node	NNS	NNS	_	32	conj	_	_
37	with	with	IN	IN	_	39	case	_	_
38	follicular	follicular	JJ	JJ	_	39	amod	_	_
39	hyperplasia	hyperplasia	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	5	amod	_	_
2	p65	p65	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	c-Rel	c-rel	NN	NN	_	2	conj	_	_
5	proteins	protein	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	all	all	DT	DT	_	11	det	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	types	type	NNS	NNS	_	7	nmod	_	_
12	including	include	VBG	VBG	_	13	case	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	germinal	germinal	JJ	JJ	_	4	amod	_	_
3	centers	center	NNS	NNS	_	4	compound	_	_
4	GC	gc	NN	NN	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	p50	p50	NN	NN	_	13	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	p52	p52	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	RelB	relb	NN	NN	_	6	conj	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nuclei	nucleus	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	FDC	fdc	NN	NN	_	16	nmod	_	_
19	only	only	RB	RB	_	16	advmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	were	be	VBD	VBD	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	detected	detect	VBN	VBN	_	13	conj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	nuclei	nucleus	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	CD68+	cd68+	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	areas	area	NNS	NNS	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	p50	p50	NN	NN	_	13	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	p52	p52	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	RelB	relb	NN	NN	_	6	conj	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nuclei	nucleus	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	HLA-DR+	hla-dr+	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	with	with	IN	IN	_	27	case	_	_
21	an	a	DT	DT	_	27	det	_	_
22	antigen-presenting	antigen-presenting	JJ	JJ	_	23	amod	_	_
23	cell	cell	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	APC	apc	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	morphology	morphology	NN	NN	_	19	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	p52	p52	NN	NN	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	RelB	relb	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nuclei	nucleus	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	CD1a+	cd1a+	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CD68+	cd68+	JJ	JJ	_	11	conj	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	from	from	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	area	area	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	5	punct	_	_
21	whereas	whereas	IN	IN	_	5	dep	_	_
22	p50	p50	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	found	find	VBN	VBN	_	5	parataxis	_	_
25	only	only	RB	RB	_	30	advmod	_	_
26	in	in	IN	IN	_	30	case	_	_
27	CD68-	cd68-	JJ	JJ	_	30	amod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD1a-	cd1a-	JJ	JJ	_	27	conj	_	_
30	cells	cell	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	Cells	cell	NNS	NNS	_	6	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	p50	p50	NN	NN	_	1	nmod	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	negative	negative	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	CD38	cd38	NN	NN	_	14	compound	_	_
10	,	,	,	,	_	9	punct	_	_
11	CD20	cd20	NN	NN	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	CD2	cd2	NN	NN	_	9	conj	_	_
14	markers	marker	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	,	,	,	,	_	19	punct	_	_
6	physiologically	physiologically	RB	RB	_	19	advmod	_	_
7	,	,	,	,	_	19	punct	_	_
8	high	high	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	19	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	nuclear	nuclear	JJ	JJ	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	p50	p50	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	p52	p52	NN	NN	_	13	conj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	RelB	relb	NN	NN	_	13	conj	_	_
18	are	be	VBP	VBP	_	19	aux	_	_
19	restricted	restricted	JJ	JJ	_	3	ccomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	accessory	accessory	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	immune	immune	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	22	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	include	include	VBP	VBP	_	22	acl:relcl	_	_
30	FDC	fdc	NN	NN	_	29	dobj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	GC	gc	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	22	punct	_	_
34	and	and	CC	CC	_	22	cc	_	_
35	DC	dc	NN	NN	_	22	conj	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	macrophages	macrophage	NNS	NNS	_	35	conj	_	_
38	in	in	IN	IN	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	T	t	NN	NN	_	42	compound	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	zone	zone	NN	NN	_	35	nmod	_	_
43	,	,	,	,	_	19	punct	_	_
44	that	that	IN	IN	_	52	mark	_	_
45	specialized	specialize	VBN	VBN	_	47	amod	_	_
46	scavenger	scavenger	NN	NN	_	47	compound	_	_
47	macrophages	macrophage	NNS	NNS	_	52	nsubj	_	_
48	from	from	IN	IN	_	49	case	_	_
49	GC	gc	NN	NN	_	47	nmod	_	_
50	do	do	VBP	VBP	_	52	aux	_	_
51	not	not	RB	RB	_	52	neg	_	_
52	have	have	VB	VB	_	19	conj	_	_
53	detectable	detectable	JJ	JJ	_	54	amod	_	_
54	levels	level	NNS	NNS	_	52	dobj	_	_
55	of	of	IN	IN	_	56	case	_	_
56	p52	p52	NN	NN	_	54	nmod	_	_
57	and	and	CC	CC	_	56	cc	_	_
58	RelB	relb	NN	NN	_	56	conj	_	_
59	,	,	,	,	_	52	punct	_	_
60	whereas	whereas	IN	IN	_	52	dep	_	_
61	macrophages	macrophage	NNS	NNS	_	78	nsubj	_	_
62	from	from	IN	IN	_	66	case	_	_
63	the	the	DT	DT	_	66	det	_	_
64	T	t	NN	NN	_	66	compound	_	_
65	cell	cell	NN	NN	_	66	compound	_	_
66	area	area	NN	NN	_	61	nmod	_	_
67	,	,	,	,	_	61	punct	_	_
68	known	know	VBN	VBN	_	61	acl	_	_
69	to	to	TO	TO	_	70	mark	_	_
70	present	present	VB	VB	_	68	xcomp	_	_
71	the	the	DT	DT	_	72	det	_	_
72	antigen	antigen	NN	NN	_	70	dobj	_	_
73	to	to	TO	TO	_	75	case	_	_
74	T	t	NN	NN	_	75	compound	_	_
75	cells	cell	NNS	NNS	_	70	nmod	_	_
76	,	,	,	,	_	61	punct	_	_
77	do	do	VBP	VBP	_	78	aux	_	_
78	have	have	VB	VB	_	52	parataxis	_	_
79	both	both	CC	CC	_	81	cc:preconj	_	_
80	nuclear	nuclear	JJ	JJ	_	81	dep	_	_
81	p52	p52	NN	NN	_	78	dobj	_	_
82	and	and	CC	CC	_	81	cc	_	_
83	RelB	relb	NN	NN	_	81	conj	_	_
84	,	,	,	,	_	19	punct	_	_
85	and	and	CC	CC	_	19	cc	_	_
86	that	that	IN	IN	_	97	mark	_	_
87	in	in	IN	IN	_	91	case	_	_
88	the	the	DT	DT	_	91	det	_	_
89	T	t	NN	NN	_	91	compound	_	_
90	cell	cell	NN	NN	_	91	compound	_	_
91	zone	zone	NN	NN	_	97	nmod	_	_
92	,	,	,	,	_	97	punct	_	_
93	p52	p52	NN	NN	_	97	nsubj	_	_
94	and	and	CC	CC	_	93	cc	_	_
95	RelB	relb	NN	NN	_	93	conj	_	_
96	are	be	VBP	VBP	_	97	cop	_	_
97	located	located	JJ	JJ	_	19	conj	_	_
98	in	in	IN	IN	_	99	case	_	_
99	nuclei	nucleus	NNS	NNS	_	97	nmod	_	_
100	of	of	IN	IN	_	109	case	_	_
101	both	both	DT	DT	_	102	cc:preconj	_	_
102	CD1a+	cd1a+	JJ	JJ	_	109	amod	_	_
103	,	,	,	,	_	102	punct	_	_
104	CD68+	cd68+	JJ	JJ	_	102	conj	_	_
105	or	or	CC	CC	_	102	cc	_	_
106	both	both	DT	DT	_	102	conj	_	_
107	,	,	,	,	_	102	punct	_	_
108	cells	cell	NNS	NNS	_	109	compound	_	_
109	APC	apc	NN	NN	_	99	nmod	_	_
110	,	,	,	,	_	97	punct	_	_
111	whereas	whereas	IN	IN	_	97	dep	_	_
112	p50	p50	NN	NN	_	114	nsubj	_	_
113	is	be	VBZ	VBZ	_	114	aux	_	_
114	restricted	restricted	JJ	JJ	_	97	parataxis	_	_
115	to	to	TO	TO	_	119	case	_	_
116	CD1a-	cd1a-	NN	NN	_	119	amod	_	_
117	and	and	CC	CC	_	116	cc	_	_
118	CD68-	cd68-	JJ	JJ	_	116	conj	_	_
119	APC	apc	NN	NN	_	114	nmod	_	_
120	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	patterns	pattern	NNS	NNS	_	14	nsubj	_	_
4	of	of	IN	IN	_	12	case	_	_
5	p50	p50	NN	NN	_	12	compound	_	_
6	,	,	,	,	_	5	punct	_	_
7	p52	p52	NN	NN	_	5	conj	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	RelB	relb	NN	NN	_	5	conj	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	localization	localization	NN	NN	_	3	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	provide	provide	VB	VB	_	0	root	_	_
15	insight	insight	NN	NN	_	14	dobj	_	_
16	into	into	IN	IN	_	19	case	_	_
17	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	roles	role	NNS	NNS	_	15	nmod	_	_
20	during	during	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	19	nmod	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vivo	vivo	FW	FW	_	23	advmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	transduction	transduction	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	4	case	_	_
4	DR3	dr3	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	death	death	NN	NN	_	8	nmod:npmod	_	_
8	domain-containing	domain-containing	JJ	JJ	_	9	amod	_	_
9	receptor	receptor	NN	NN	_	4	appos	_	_
10	related	related	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	TNFR-1	tnfr-1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	CD95	cd95	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	2	punct	_	_

1	Tumor	tumor	NN	NN	_	4	compound	_	_
2	necrosis	necrosis	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	receptor-1	receptor-1	NN	NN	_	19	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	TNFR-1	tnfr-1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	CD95	cd95	NN	NN	_	4	conj	_	_
10	(	(	-LRB-	-LRB-	_	9	punct	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	called	call	VBN	VBN	_	9	acl	_	_
13	Fas	fas	NN	NN	_	12	xcomp	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	APO-1	apo-1	NN	NN	_	13	conj	_	_
16	)	)	-RRB-	-RRB-	_	9	punct	_	_
17	are	be	VBP	VBP	_	19	cop	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	0	root	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	engage	engage	VBP	VBP	_	19	acl:relcl	_	_
22	the	the	DT	DT	_	24	det	_	_
23	apoptosis	apoptosis	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	21	dobj	_	_
25	through	through	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	region	region	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	intracellular	intracellular	JJ	JJ	_	30	amod	_	_
30	homology	homology	NN	NN	_	27	nmod	_	_
31	,	,	,	,	_	24	punct	_	_
32	designated	designate	VBD	VBD	_	24	acl	_	_
33	the	the	DT	DT	_	36	det	_	_
34	``	``	``	``	_	36	punct	_	_
35	death	death	NN	NN	_	36	compound	_	_
36	domain	domain	NN	NN	_	32	xcomp	_	_
37	.	.	.	.	_	19	punct	_	_

1	Another	another	DT	DT	_	4	det	_	_
2	death	death	NN	NN	_	3	dep	_	_
3	domain-containing	domain-containing	NN	NN	_	4	amod	_	_
4	member	member	NN	NN	_	18	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TNFR	tnfr	NN	NN	_	8	compound	_	_
8	family	family	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	death	death	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	4	appos	_	_
12	3	3	CD	CD	_	11	nummod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	DR3	dr3	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	4	punct	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	identified	identify	VBN	VBN	_	0	root	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	shown	show	VBN	VBN	_	18	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	induce	induce	VB	VB	_	21	xcomp	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	apoptosis	apoptosis	NNS	NNS	_	23	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	activation	activation	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	kappaB	kappab	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	18	punct	_	_

1	Expression	expression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	DR3	dr3	NN	NN	_	1	nmod	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	aux	_	_
7	restricted	restricted	JJ	JJ	_	4	xcomp	_	_
8	to	to	TO	TO	_	9	case	_	_
9	tissues	tissue	NNS	NNS	_	7	nmod	_	_
10	enriched	enrich	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	DR3	dr3	NN	NN	_	3	compound	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	transduction	transduction	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	mediated	mediate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	complex	complex	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
11	signaling	signal	VBG	VBG	_	12	amod	_	_
12	molecules	molecule	NNS	NNS	_	8	nmod	_	_
13	including	include	VBG	VBG	_	14	case	_	_
14	TRADD	tradd	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	TRAF2	traf2	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	FADD	fadd	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	FLICE	flice	NN	NN	_	14	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	DR3	dr3	NN	NN	_	5	nsubj	_	_
4	likely	likely	RB	RB	_	5	advmod	_	_
5	plays	play	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	regulating	regulate	VBG	VBG	_	5	advcl	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	homeostasis	homeostasis	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	5	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	expression	expression	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus-encoded	virus-encoded	JJ	JJ	_	8	amod	_	_
8	dUTPase	dutpase	NN	NN	_	1	nmod	_	_
9	:	:	:	:	_	1	punct	_	_
10	patients	patient	NNS	NNS	_	19	nsubj	_	_
11	with	with	IN	IN	_	18	case	_	_
12	acute	acute	JJ	JJ	_	18	amod	_	_
13	,	,	,	,	_	12	punct	_	_
14	reactivated	reactivate	VBN	VBN	_	12	conj	_	_
15	or	or	CC	CC	_	12	cc	_	_
16	chronic	chronic	JJ	JJ	_	12	conj	_	_
17	virus	virus	NN	NN	_	18	compound	_	_
18	infection	infection	NN	NN	_	10	nmod	_	_
19	develop	develop	VBP	VBP	_	1	dep	_	_
20	antibodies	antibody	NNS	NNS	_	19	dobj	_	_
21	against	against	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	enzyme	enzyme	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	13	nsubjpass	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	11	det	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	6	amod	_	_
6	virus	virus	NN	NN	_	10	dep	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	EBV	ebv	NN	NN	_	10	nmod:npmod	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	-specific	-specific	JJ	JJ	_	11	amod	_	_
11	dUTPase	dutpase	NN	NN	_	3	dobj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	amplified	amplify	VBN	VBN	_	0	root	_	_
14	from	from	IN	IN	_	16	case	_	_
15	virus	virus	NN	NN	_	16	compound	_	_
16	DNA	dna	NN	NN	_	13	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	PCR	pcr	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	enzyme	enzyme	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Escherichia	escherichia	FW	FW	_	8	compound	_	_
8	coli	coli	FW	FW	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	in	in	IN	IN	_	12	case	_	_
11	insect	insect	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	conj	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	non-fusion	non-fusion	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	5	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	7	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	E.	e.	FW	FW	_	5	compound	_	_
5	coli	coli	FW	FW	_	2	nmod	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	converted	convert	VBD	VBD	_	0	root	_	_
8	dUTP	dutp	NN	NN	_	7	dobj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	dUMP	dump	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	react	react	VB	VB	_	7	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	other	other	JJ	JJ	_	17	amod	_	_
17	dNTPs	dntp	NNS	NNS	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	NTPs	ntp	NNS	NNS	_	17	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Preliminary	preliminary	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	yielded	yield	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	Km	km	NN	NN	_	6	compound	_	_
6	value	value	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	about	about	RB	RB	_	9	advmod	_	_
9	0.8	0.8	CD	CD	_	10	nummod	_	_
10	microM	microm	NN	NN	_	6	nmod	_	_
11	for	for	IN	IN	_	12	case	_	_
12	dUTP	dutp	NN	NN	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	MAbs	mab	NNS	NNS	_	5	nsubj	_	_
2	against	against	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	dUTPase	dutpase	NN	NN	_	1	nmod	_	_
5	reacted	react	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	approximately	approximately	RB	RB	_	11	advmod	_	_
11	31	31	CD	CD	_	12	nummod	_	_
12	kDa	kda	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	20	case	_	_
14	12-O-tetradecanoyl-phorbol-13-acetate	12-o-tetradecanoyl-phorbol-13-acetate	NN	NN	_	18	dep	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	TPA	tpa	NN	NN	_	18	nmod:npmod	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	-stimulated	-stimulated	JJ	JJ	_	20	amod	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	8	nmod	_	_
21	harbouring	harbour	VBG	VBG	_	20	acl	_	_
22	either	either	CC	CC	_	23	cc:preconj	_	_
23	type	type	NN	NN	_	28	compound	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	or	or	CC	CC	_	23	cc	_	_
26	type	type	NN	NN	_	23	conj	_	_
27	2	2	CD	CD	_	26	nummod	_	_
28	EBV	ebv	NN	NN	_	21	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	untreated	untreated	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	at	at	IN	IN	_	10	case	_	_
9	low	low	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	4	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	whereas	whereas	IN	IN	_	4	dep	_	_
13	induction	induction	NN	NN	_	32	nsubj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	lytic	lytic	JJ	JJ	_	18	amod	_	_
17	replication	replication	NN	NN	_	18	compound	_	_
18	cycle	cycle	NN	NN	_	13	nmod	_	_
19	by	by	IN	IN	_	21	case	_	_
20	TPA	tpa	NN	NN	_	21	compound	_	_
21	treatment	treatment	NN	NN	_	13	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	providing	provide	VBG	VBG	_	21	conj	_	_
25	the	the	DT	DT	_	29	det	_	_
26	immediate	immediate	JJ	JJ	_	29	amod	_	_
27	early	early	JJ	JJ	_	29	amod	_	_
28	transactivator	transactivator	NN	NN	_	29	compound	_	_
29	BZLF1	bzlf1	NN	NN	_	24	dobj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	trans	trans	NN	NN	_	13	nmod	_	_
32	resulted	result	VBD	VBD	_	4	parataxis	_	_
33	in	in	IN	IN	_	35	case	_	_
34	increased	increase	VBN	VBN	_	35	amod	_	_
35	expression	expression	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	dUTPase	dutpase	NN	NN	_	13	nsubj	_	_
7	isolated	isolate	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	10	case	_	_
9	EBV-infected	ebv-infected	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	a	a	DT	DT	_	13	det	_	_
13	phosphoprotein	phosphoprotein	NN	NN	_	2	ccomp	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	8	nsubjpass	_	_
3	expressed	express	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	6	case	_	_
5	insect	insect	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	test	test	VB	VB	_	8	xcomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	antibodies	antibody	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	sera	sera	NN	NN	_	13	nmod	_	_
19	from	from	IN	IN	_	23	case	_	_
20	normal	normal	JJ	JJ	_	23	amod	_	_
21	,	,	,	,	_	20	punct	_	_
22	healthy	healthy	JJ	JJ	_	20	dep	_	_
23	carriers	carrier	NNS	NNS	_	18	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	from	from	IN	IN	_	26	case	_	_
26	patients	patient	NNS	NNS	_	23	conj	_	_
27	with	with	IN	IN	_	29	case	_	_
28	various	various	JJ	JJ	_	29	amod	_	_
29	diseases	disease	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	While	while	IN	IN	_	18	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	sera	sera	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	EBV-negative	ebv-negative	JJ	JJ	_	6	amod	_	_
6	individuals	individual	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	0/3	0/3	CD	CD	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	or	or	CC	CC	_	6	cc	_	_
11	healthy	healthy	JJ	JJ	_	12	amod	_	_
12	carriers	carrier	NNS	NNS	_	6	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	0/33	0/33	CD	CD	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	did	do	VBD	VBD	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	contain	contain	VB	VB	_	51	advcl	_	_
19	detectable	detectable	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	antibodies	antibody	NNS	NNS	_	20	nmod	_	_
23	,	,	,	,	_	51	punct	_	_
24	patients	patient	NNS	NNS	_	51	nsubj	_	_
25	with	with	IN	IN	_	26	case	_	_
26	mononucleosis	mononucleosis	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	5/18	5/18	CD	CD	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	26	punct	_	_
31	chronic	chronic	JJ	JJ	_	33	amod	_	_
32	EBV	ebv	NN	NN	_	33	compound	_	_
33	infection	infection	NN	NN	_	26	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	2/7	2/7	CD	CD	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	,	,	,	,	_	26	punct	_	_
38	EBV	ebv	NN	NN	_	39	compound	_	_
39	reactivation	reactivation	NN	NN	_	26	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	7/20	7/20	CD	CD	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	and	and	CC	CC	_	26	cc	_	_
44	human	human	JJ	JJ	_	47	amod	_	_
45	immunodeficiency	immunodeficiency	NN	NN	_	47	compound	_	_
46	virus	virus	NN	NN	_	47	compound	_	_
47	infection	infection	NN	NN	_	26	conj	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	5/24	5/24	CD	CD	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	showed	show	VBD	VBD	_	0	root	_	_
52	elevated	elevated	JJ	JJ	_	54	amod	_	_
53	antibody	antibody	NN	NN	_	54	compound	_	_
54	titres	titre	NNS	NNS	_	51	dobj	_	_
55	against	against	IN	IN	_	57	case	_	_
56	the	the	DT	DT	_	57	det	_	_
57	enzyme	enzyme	NN	NN	_	54	nmod	_	_
58	.	.	.	.	_	51	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicated	indicate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	dUTPase	dutpase	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	2	ccomp	_	_
8	during	during	IN	IN	_	9	case	_	_
9	EBV	ebv	NN	NN	_	7	nmod	_	_
10	replication	replication	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	reactivation	reactivation	NN	NN	_	10	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	enzyme	enzyme	NN	NN	_	8	nsubj	_	_
3	might	might	MD	MD	_	8	aux	_	_
4	therefore	therefore	RB	RB	_	8	advmod	_	_
5	be	be	VB	VB	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	potential	potential	JJ	JJ	_	8	amod	_	_
8	target	target	NN	NN	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	drug	drug	NN	NN	_	11	compound	_	_
11	therapy	therapy	NN	NN	_	8	nmod	_	_
12	under	under	IN	IN	_	13	case	_	_
13	conditions	condition	NNS	NNS	_	8	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	active	active	JJ	JJ	_	17	amod	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	replication	replication	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Prostaglandin	prostaglandin	NN	NN	_	3	compound	_	_
2	E2	e2	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	11	case	_	_
8	CRE	cre	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP-2	ap-2	NN	NN	_	8	conj	_	_
11	elements	element	NNS	NNS	_	6	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Prostaglandins	Prostaglandins	NNP	NNP	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	E	e	NN	NN	_	5	compound	_	_
5	series	series	NNS	NNS	_	1	nmod	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	immunomodulatory	immunomodulatory	JJ	JJ	_	8	amod	_	_
8	agents	agent	NNS	NNS	_	0	root	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	exert	exert	VBP	VBP	_	8	acl:relcl	_	_
11	inhibitory	inhibitory	JJ	JJ	_	16	amod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	stimulatory	stimulatory	JJ	JJ	_	11	conj	_	_
16	effects	effect	NNS	NNS	_	10	dobj	_	_
17	on	on	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	variety	variety	NN	NN	_	10	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	immune	immune	JJ	JJ	_	22	amod	_	_
22	responses	response	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	it	it	PRP	PRP	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	known	know	VBN	VBN	_	15	advcl	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	PGE2	pge2	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	able	able	JJ	JJ	_	4	ccomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	increase	increase	VB	VB	_	8	xcomp	_	_
11	cAMP	camp	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	10	dobj	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	investigated	investigate	VBD	VBD	_	0	root	_	_
16	whether	whether	IN	IN	_	19	mark	_	_
17	it	it	PRP	PRP	_	19	nsubj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	affect	affect	VB	VB	_	15	ccomp	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	through	through	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	activation	activation	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	24	nmod	_	_
29	which	which	WDT	WDT	_	30	nsubj	_	_
30	bind	bind	VBP	VBP	_	28	acl:relcl	_	_
31	enhancer	enhancer	NN	NN	_	32	compound	_	_
32	elements	element	NNS	NNS	_	30	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	promoter	promoter	NN	NN	_	36	compound	_	_
36	regions	region	NNS	NNS	_	32	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	cAMP-regulated	camp-regulated	JJ	JJ	_	39	amod	_	_
39	genes	gene	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	15	punct	_	_

1	Using	use	VBG	VBG	_	8	advcl	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	19	mark	_	_
10	a	a	DT	DT	_	12	det	_	_
11	short	short	JJ	JJ	_	12	amod	_	_
12	treatment	treatment	NN	NN	_	19	nsubj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	PGE2	pge2	NN	NN	_	12	nmod	_	_
19	induces	induce	VBZ	VBZ	_	8	ccomp	_	_
20	specific	specific	JJ	JJ	_	22	amod	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	dobj	_	_
23	to	to	TO	TO	_	33	case	_	_
24	CRE	cre	NN	NN	_	33	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	AP-2	ap-2	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	but	but	CC	CC	_	29	cc	_	_
29	not	not	RB	RB	_	26	appos	_	_
30	AP-1	ap-1	NN	NN	_	26	dep	_	_
31	,	,	,	,	_	26	punct	_	_
32	DNA	dna	NN	NN	_	33	compound	_	_
33	elements	element	NNS	NNS	_	22	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	12	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	okadaic	okadaic	JJ	JJ	_	4	amod	_	_
4	acid	acid	NN	NN	_	12	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	10	det	_	_
7	potent	potent	JJ	JJ	_	10	amod	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	phosphatase	phosphatase	NN	NN	_	10	compound	_	_
10	inhibitor	inhibitor	NN	NN	_	4	appos	_	_
11	,	,	,	,	_	4	punct	_	_
12	prolongs	prolong	VBZ	VBZ	_	23	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	phosphorylation	phosphorylation	NN	NN	_	21	compound	_	_
21	events	event	NNS	NNS	_	23	nsubj	_	_
22	are	be	VBP	VBP	_	23	cop	_	_
23	likely	likely	JJ	JJ	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	occur	occur	VB	VB	_	23	xcomp	_	_
26	.	.	.	.	_	23	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	3	nsubj	_	_
3	seems	seem	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	10	mark	_	_
5	be	be	VB	VB	_	10	cop	_	_
6	due	due	JJ	JJ	_	10	case	_	_
7	to	to	TO	TO	_	6	mwe	_	_
8	increased	increase	VBN	VBN	_	10	amod	_	_
9	cAMP	camp	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	3	xcomp	_	_
11	because	because	IN	IN	_	15	mark	_	_
12	forskolin	forskolin	NN	NN	_	15	nsubj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IBMX	ibmx	NN	NN	_	12	conj	_	_
15	mimic	mimic	VBP	VBP	_	10	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	effects	effect	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	PGE2	pge2	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	More	more	RBR	RBR	_	2	advmod	_	_
2	interestingly	interestingly	RB	RB	_	9	advmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	transfection	transfection	NN	NN	_	5	compound	_	_
5	experiments	experiment	NNS	NNS	_	9	nsubj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	CRE-CAT	cre-cat	NN	NN	_	8	compound	_	_
8	plasmide	plasmide	NN	NN	_	5	nmod	_	_
9	show	show	VBP	VBP	_	0	root	_	_
10	that	that	IN	IN	_	12	mark	_	_
11	PGE2	pge2	NN	NN	_	12	nsubj	_	_
12	activates	activate	VBZ	VBZ	_	9	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	transcription	transcription	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	CRE-containing	cre-containing	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	positive	positive	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	PGE2	pge2	NN	NN	_	6	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	some	some	DT	DT	_	12	det	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	functions	function	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	cytokine	cytokine	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	cytokine	cytokine	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	3	conj	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	GCS	gc	NNS	NNS	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	profoundly	profoundly	RB	RB	_	6	advmod	_	_
6	inhibit	inhibit	VBP	VBP	_	0	root	_	_
7	several	several	JJ	JJ	_	8	amod	_	_
8	aspects	aspect	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	immunity	immunity	NN	NN	_	8	nmod	_	_
13	largely	largely	RB	RB	_	15	advmod	_	_
14	through	through	IN	IN	_	15	case	_	_
15	inhibition	inhibition	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	cytokine	cytokine	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	at	at	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	posttranscriptional	posttranscriptional	JJ	JJ	_	21	conj	_	_
24	levels	level	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	GCS	gc	NNS	NNS	_	4	nsubjpass	_	_
2	were	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	act	act	VB	VB	_	4	xcomp	_	_
7	indirectly	indirectly	RB	RB	_	6	advmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	inducing	induce	VBG	VBG	_	6	advcl	_	_
10	transforming	transform	VBG	VBG	_	13	amod	_	_
11	growth	growth	NN	NN	_	13	compound	_	_
12	factor-beta	factor-beta	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	18	nsubj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	turn	turn	NN	NN	_	18	nmod	_	_
18	blocks	block	VBZ	VBZ	_	13	acl:relcl	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	immunity	immunity	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	mark	_	_
2	exerting	exert	VBG	VBG	_	8	advcl	_	_
3	their	they	PRP$	PRP$	_	5	nmod:poss	_	_
4	antiproliferative	antiproliferative	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	GCS	gc	NNS	NNS	_	8	nsubj	_	_
8	diffuse	diffuse	VBP	VBP	_	0	root	_	_
9	into	into	IN	IN	_	11	case	_	_
10	target	target	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	where	where	WRB	WRB	_	14	advmod	_	_
13	they	they	PRP	PRP	_	14	nsubj	_	_
14	bind	bind	VBP	VBP	_	11	acl:relcl	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
17	receptor	receptor	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	turn	turn	NN	NN	_	22	nmod	_	_
22	translocates	translocate	VBZ	VBZ	_	17	acl:relcl	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	nucleus	nucleus	NN	NN	_	22	nmod	_	_
26	where	where	WRB	WRB	_	28	advmod	_	_
27	it	it	PRP	PRP	_	28	nsubj	_	_
28	inhibits	inhibit	VBZ	VBZ	_	25	acl:relcl	_	_
29	transcription	transcription	NN	NN	_	28	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	cytokine	cytokine	NN	NN	_	32	compound	_	_
32	genes	gene	NNS	NNS	_	29	nmod	_	_
33	through	through	IN	IN	_	35	case	_	_
34	direct	direct	JJ	JJ	_	35	amod	_	_
35	binding	binding	NN	NN	_	28	nmod	_	_
36	to	to	TO	TO	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	glucocorticoid	glucocorticoid	NN	NN	_	40	compound	_	_
39	response	response	NN	NN	_	40	compound	_	_
40	elements	element	NNS	NNS	_	35	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	GRE	gre	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	,	,	,	,	_	40	punct	_	_
45	which	which	WDT	WDT	_	47	nsubj	_	_
46	are	be	VBP	VBP	_	47	cop	_	_
47	located	located	JJ	JJ	_	40	acl:relcl	_	_
48	in	in	IN	IN	_	51	case	_	_
49	the	the	DT	DT	_	51	det	_	_
50	promoter	promoter	NN	NN	_	51	compound	_	_
51	region	region	NN	NN	_	47	nmod	_	_
52	of	of	IN	IN	_	54	case	_	_
53	cytokine	cytokine	NN	NN	_	54	compound	_	_
54	genes	gene	NNS	NNS	_	51	nmod	_	_
55	or	or	CC	CC	_	35	cc	_	_
56	,	,	,	,	_	35	punct	_	_
57	alternatively	alternatively	RB	RB	_	60	advmod	_	_
58	,	,	,	,	_	60	punct	_	_
59	through	through	IN	IN	_	60	case	_	_
60	antagonism	antagonism	NN	NN	_	35	conj	_	_
61	of	of	IN	IN	_	63	case	_	_
62	the	the	DT	DT	_	63	det	_	_
63	action	action	NN	NN	_	60	nmod	_	_
64	of	of	IN	IN	_	66	case	_	_
65	transcription	transcription	NN	NN	_	66	compound	_	_
66	factors	factor	NNS	NNS	_	63	nmod	_	_
67	required	require	VBN	VBN	_	66	acl	_	_
68	for	for	IN	IN	_	71	case	_	_
69	optimal	optimal	JJ	JJ	_	71	amod	_	_
70	transcriptional	transcriptional	JJ	JJ	_	71	amod	_	_
71	activation	activation	NN	NN	_	67	nmod	_	_
72	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	contrast	contrast	NN	NN	_	6	dep	_	_
3	to	to	TO	TO	_	6	case	_	_
4	their	they	PRP$	PRP$	_	6	nmod:poss	_	_
5	inhibitory	inhibitory	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	12	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	cytokine	cytokine	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	GCS	gc	NNS	NNS	_	12	nsubj	_	_
12	up-regulate	up-regulate	VBP	VBP	_	0	root	_	_
13	cytokine	cytokine	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	correlates	correlate	VBZ	VBZ	_	15	acl:relcl	_	_
18	with	with	IN	IN	_	21	case	_	_
19	enhanced	enhance	VBN	VBN	_	21	amod	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	effects	effect	NNS	NNS	_	17	nmod	_	_
22	on	on	IN	IN	_	24	case	_	_
23	target	target	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	summarize	summarize	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	current	current	JJ	JJ	_	9	amod	_	_
9	state	state	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	knowledge	knowledge	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	mechanism	mechanism	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	action	action	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	GCS	gc	NNS	NNS	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	including	include	VBG	VBG	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	phenomenon	phenomenon	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	steroid-induced	steroid-induced	JJ	JJ	_	25	amod	_	_
25	rebound	rebound	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	16	punct	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	ensues	ensue	VBZ	VBZ	_	16	acl:relcl	_	_
29	upon	upon	IN	IN	_	31	case	_	_
30	GCS	gc	NNS	NNS	_	31	compound	_	_
31	withdrawal	withdrawal	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Oct-2	oct-2	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Oct-2	oct-2	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	member	member	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	POU	pou	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Pit-Oct-Unc	pit-oct-unc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	family	family	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	expressed	express	VBN	VBN	_	7	conj	_	_
21	only	only	RB	RB	_	20	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	in	in	IN	IN	_	28	case	_	_
27	neuronal	neuronal	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	24	conj	_	_
29	but	but	CC	CC	_	21	cc	_	_
30	not	not	RB	RB	_	34	neg	_	_
31	in	in	IN	IN	_	34	case	_	_
32	other	other	JJ	JJ	_	34	amod	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	types	type	NNS	NNS	_	21	conj	_	_
35	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	primary	primary	JJ	JJ	_	4	amod	_	_
3	RNA	rna	NN	NN	_	4	compound	_	_
4	transcript	transcript	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	gene	gene	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	subject	subject	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	alternative	alternative	JJ	JJ	_	12	amod	_	_
12	splicing	splicing	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	yield	yield	VB	VB	_	9	xcomp	_	_
15	different	different	JJ	JJ	_	16	amod	_	_
16	variants	variant	NNS	NNS	_	14	dobj	_	_
17	which	which	WDT	WDT	_	20	nsubj	_	_
18	can	can	MD	MD	_	20	aux	_	_
19	either	either	CC	CC	_	20	cc:preconj	_	_
20	activate	activate	VBP	VBP	_	16	acl:relcl	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	repress	repress	VBP	VBP	_	20	conj	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	forms	form	NNS	NNS	_	7	nsubj	_	_
3	produced	produce	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	6	case	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
7	have	have	VBP	VBP	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	predominantly	predominantly	RB	RB	_	10	advmod	_	_
10	activating	activating	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	7	dobj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	7	nmod	_	_
15	whereas	whereas	IN	IN	_	7	dep	_	_
16	those	those	DT	DT	_	21	nsubj	_	_
17	produced	produce	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	neuronal	neuronal	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	have	have	VBP	VBP	_	7	parataxis	_	_
22	a	a	DT	DT	_	25	det	_	_
23	predominantly	predominantly	RB	RB	_	24	advmod	_	_
24	inhibitory	inhibitory	JJ	JJ	_	25	amod	_	_
25	effect	effect	NN	NN	_	21	dobj	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	can	can	MD	MD	_	28	aux	_	_
28	repress	repress	VB	VB	_	21	conj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	expression	expression	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	38	case	_	_
32	both	both	CC	CC	_	38	cc:preconj	_	_
33	the	the	DT	DT	_	38	det	_	_
34	herpes	herpes	NN	NN	_	38	compound	_	_
35	simplex	simplex	NN	NN	_	38	compound	_	_
36	virus	virus	NN	NN	_	38	compound	_	_
37	immediate-early	immediate-early	JJ	JJ	_	38	amod	_	_
38	genes	gene	NNS	NNS	_	30	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	the	the	DT	DT	_	44	det	_	_
41	cellular	cellular	JJ	JJ	_	44	amod	_	_
42	tyrosine	tyrosine	NN	NN	_	44	compound	_	_
43	hydroxylase	hydroxylase	NN	NN	_	44	compound	_	_
44	gene	gene	NN	NN	_	38	conj	_	_
45	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	3	advmod	_	_
2	Oct-2	oct-2	NN	NN	_	3	nsubj	_	_
3	plays	play	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	cellular	cellular	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	neuronal	neuronal	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	as	as	RB	RB	_	9	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	control	control	NN	NN	_	9	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	viral	viral	JJ	JJ	_	29	amod	_	_
29	latency	latency	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Tissue	tissue	NN	NN	_	4	nmod:npmod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cell-type	cell-type	JJ	JJ	_	1	conj	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	tuberous	tuberous	JJ	JJ	_	10	amod	_	_
9	sclerosis	sclerosis	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	TSC2	tsc2	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	tissues	tissue	NNS	NNS	_	5	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	TSC2	tsc2	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	gene	gene	NN	NN	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	chromosome	chromosome	NN	NN	_	7	compound	_	_
7	16p13.3	16p13.3	NN	NN	_	4	nmod	_	_
8	associated	associate	VBN	VBN	_	4	acl	_	_
9	with	with	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	autosomal	autosomal	JJ	JJ	_	14	amod	_	_
12	dominant	dominant	JJ	JJ	_	14	amod	_	_
13	neurocutaneous	neurocutaneous	JJ	JJ	_	14	amod	_	_
14	disorder	disorder	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	tuberous	tuberous	JJ	JJ	_	18	amod	_	_
17	sclerosis	sclerosis	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	14	appos	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TSC	tsc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	18	advcl	_	_
3	a	a	DT	DT	_	6	det	_	_
4	partial	partial	JJ	JJ	_	6	amod	_	_
5	nucleotide	nucleotide	JJ	JJ	_	6	amod	_	_
6	sequence	sequence	NN	NN	_	2	dobj	_	_
7	from	from	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cloned	clone	VBN	VBN	_	10	amod	_	_
10	TSC2	tsc2	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	polymerase	polymerase	NN	NN	_	15	compound	_	_
13	chain	chain	NN	NN	_	15	compound	_	_
14	reaction	reaction	NN	NN	_	15	compound	_	_
15	methodology	methodology	NN	NN	_	6	conj	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	constructed	construct	VBD	VBD	_	0	root	_	_
19	a	a	DT	DT	_	23	det	_	_
20	digoxigenin-labeled	digoxigenin-labeled	JJ	JJ	_	23	amod	_	_
21	complementary	complementary	JJ	JJ	_	23	amod	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	probe	probe	NN	NN	_	18	dobj	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	examine	examine	VB	VB	_	18	advcl	_	_
26	TSC2	tsc2	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	34	case	_	_
30	autopsy-	autopsy-	NN	NN	_	34	amod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	biopsy-derived	biopsy-derived	JJ	JJ	_	30	conj	_	_
33	human	human	JJ	JJ	_	34	amod	_	_
34	tissues	tissue	NNS	NNS	_	28	nmod	_	_
35	by	by	IN	IN	_	38	case	_	_
36	in	in	FW	FW	_	38	amod	_	_
37	situ	situ	FW	FW	_	36	dep	_	_
38	hybridization	hybridization	NN	NN	_	25	nmod	_	_
39	.	.	.	.	_	18	punct	_	_

1	TSC2	tsc2	NN	NN	_	3	compound	_	_
2	messenger	messenger	NN	NN	_	3	compound	_	_
3	RNA	rna	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	widely	widely	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	various	various	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	types	type	NNS	NNS	_	6	nmod	_	_
11	throughout	throughout	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	body	body	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	including	include	VBG	VBG	_	16	case	_	_
16	epithelia	epithelia	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	cells	cell	NNS	NNS	_	16	conj	_	_
22	with	with	IN	IN	_	24	case	_	_
23	endocrine	endocrine	JJ	JJ	_	24	amod	_	_
24	functions	function	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	e.g.	e.g.	FW	FW	_	29	advmod	_	_
27	,	,	,	,	_	29	punct	_	_
28	adrenal	adrenal	JJ	JJ	_	29	amod	_	_
29	cortex	cortex	NN	NN	_	21	appos	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	anterior	anterior	JJ	JJ	_	32	amod	_	_
32	pituitary	pituitary	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	13	nsubjpass	_	_
2	was	be	VBD	VBD	_	13	auxpass	_	_
3	prominently	prominently	RB	RB	_	4	advmod	_	_
4	and	and	CC	CC	_	13	advmod	_	_
5	selectively	selectively	RB	RB	_	4	advmod	_	_
6	(	(	-LRB-	-LRB-	_	13	punct	_	_
7	within	within	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	central	central	JJ	JJ	_	11	amod	_	_
10	nervous	nervous	JJ	JJ	_	11	amod	_	_
11	system	system	NN	NN	_	13	nmod	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	expressed	express	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	pyramidal	pyramidal	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	advcl	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cerebral	cerebral	JJ	JJ	_	20	amod	_	_
20	cortex	cortex	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	other	other	JJ	JJ	_	24	amod	_	_
23	motor	motor	NN	NN	_	24	compound	_	_
24	neurons	neuron	NNS	NNS	_	20	conj	_	_
25	,	,	,	,	_	16	punct	_	_
26	e.g.	e.g.	FW	FW	_	30	advmod	_	_
27	,	,	,	,	_	30	punct	_	_
28	in	in	IN	IN	_	30	case	_	_
29	spinal	spinal	JJ	JJ	_	30	amod	_	_
30	cord	cord	NN	NN	_	16	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	brainstem	brainstem	NN	NN	_	33	compound	_	_
33	nuclei	nucleus	NNS	NNS	_	30	conj	_	_
34	.	.	.	.	_	13	punct	_	_

1	Visceral	visceral	JJ	JJ	_	3	amod	_	_
2	TSC2	tsc2	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	comparable	comparable	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	autopsy	autopsy	NN	NN	_	8	compound	_	_
8	tissues	tissue	NNS	NNS	_	5	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	14	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	without	without	IN	IN	_	11	conj	_	_
14	TSC	tsc	NN	NN	_	10	nmod	_	_
15	;	;	:	:	_	5	punct	_	_
16	TSC2	tsc2	NN	NN	_	19	compound	_	_
17	messenger	messenger	NN	NN	_	19	compound	_	_
18	RNA	rna	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	22	nsubj	_	_
20	was	be	VBD	VBD	_	22	cop	_	_
21	most	most	RBS	RBS	_	22	advmod	_	_
22	prominent	prominent	JJ	JJ	_	5	parataxis	_	_
23	in	in	IN	IN	_	24	case	_	_
24	cells	cell	NNS	NNS	_	22	nmod	_	_
25	with	with	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	rapid	rapid	JJ	JJ	_	29	amod	_	_
28	mitotic	mitotic	JJ	JJ	_	29	amod	_	_
29	rate	rate	NN	NN	_	24	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	turnover	turnover	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	24	punct	_	_
33	e.g.	e.g.	FW	FW	_	35	advmod	_	_
34	,	,	,	,	_	35	punct	_	_
35	epithelia	epithelia	NN	NN	_	24	appos	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	35	conj	_	_
38	,	,	,	,	_	24	punct	_	_
39	with	with	IN	IN	_	51	mark	_	_
40	central	central	JJ	JJ	_	42	amod	_	_
41	nervous	nervous	JJ	JJ	_	42	amod	_	_
42	system	system	NN	NN	_	51	nsubj	_	_
43	pyramidal	pyramidal	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	42	dep	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	other	other	JJ	JJ	_	47	amod	_	_
47	neurons	neuron	NNS	NNS	_	44	conj	_	_
48	being	be	VBG	VBG	_	51	cop	_	_
49	an	a	DT	DT	_	51	det	_	_
50	obvious	obvious	JJ	JJ	_	51	amod	_	_
51	exception	exception	NN	NN	_	24	acl	_	_
52	,	,	,	,	_	24	punct	_	_
53	and/or	and/or	CC	CC	_	24	cc	_	_
54	in	in	IN	IN	_	55	case	_	_
55	cells	cell	NNS	NNS	_	24	conj	_	_
56	with	with	IN	IN	_	59	case	_	_
57	important	important	JJ	JJ	_	59	amod	_	_
58	secretory/transport	secretory/transport	NN	NN	_	59	compound	_	_
59	functions	function	NNS	NNS	_	55	nmod	_	_
60	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	widespread	widespread	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	TSC2	tsc2	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	supports	support	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	view	view	NN	NN	_	8	dobj	_	_
11	that	that	IN	IN	_	13	mark	_	_
12	it	it	PRP	PRP	_	13	nsubj	_	_
13	encodes	encode	VBZ	VBZ	_	10	ccomp	_	_
14	a	a	DT	DT	_	15	det	_	_
15	protein	protein	NN	NN	_	13	dobj	_	_
16	vital	vital	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	cell	cell	NN	NN	_	16	nmod	_	_
19	growth	growth	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	metabolism	metabolism	NN	NN	_	19	conj	_	_
22	or	or	CC	CC	_	15	cc	_	_
23	one	one	CD	CD	_	15	conj	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	functions	function	VBZ	VBZ	_	23	acl:relcl	_	_
26	as	as	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	tumor/growth	tumor/growth	NN	NN	_	29	compound	_	_
29	suppressor	suppressor	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	16	nsubjpass	_	_
4	of	of	IN	IN	_	11	case	_	_
5	human	human	JJ	JJ	_	11	amod	_	_
6	Bruton	bruton	NN	NN	_	11	nmod:poss	_	_
7	's	's	POS	POS	_	6	case	_	_
8	agammaglobulinemia	agammaglobulinemia	NN	NN	_	11	compound	_	_
9	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Btk	btk	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	regulated	regulate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	Sp1-	sp1-	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	Spi-1/PU.1-family	spi-1/pu.1-family	NN	NN	_	21	compound	_	_
21	members	member	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	16	punct	_	_

1	Bruton	bruton	NN	NN	_	5	nmod:poss	_	_
2	's	's	POS	POS	_	1	case	_	_
3	agammaglobulinemia	agammaglobulinemia	NN	NN	_	5	compound	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	13	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	Btk	btk	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	13	amod	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	kinase	kinase	NN	NN	_	0	root	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	disease	disease	NN	NN	_	14	nmod	_	_
19	X-linked	x-linked	JJ	JJ	_	20	amod	_	_
20	agammaglobulinemia	agammaglobulinemia	NN	NN	_	18	dep	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	XLA	xla	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	all	all	DT	DT	_	8	det	_	_
7	hematopoietic	hematopoietic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	exception	exception	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	T-cells	t-cell	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	plasma	plasma	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	For	for	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	pattern	pattern	NN	NN	_	16	nmod	_	_
5	the	the	DT	DT	_	8	det	_	_
6	first	first	JJ	JJ	_	8	amod	_	_
7	280	280	CD	CD	_	8	nummod	_	_
8	bp	bp	NN	NN	_	16	nsubj	_	_
9	upstream	upstream	JJ	JJ	_	8	amod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	major	major	JJ	JJ	_	15	amod	_	_
13	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
14	start	start	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	9	nmod	_	_
16	seems	seem	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	cop	_	_
19	sufficient	sufficient	JJ	JJ	_	16	xcomp	_	_
20	.	.	.	.	_	16	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	footprinting	footprinting	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	11	nsubj	_	_
5	within	within	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	part	part	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	promoter	promoter	NN	NN	_	7	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	two	two	CD	CD	_	15	nummod	_	_
13	Sp1	sp1	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	11	dobj	_	_
16	as	as	RB	RB	_	15	cc	_	_
17	well	well	RB	RB	_	16	mwe	_	_
18	as	as	IN	IN	_	16	mwe	_	_
19	a	a	DT	DT	_	20	det	_	_
20	PU-box	pu-box	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	13	nsubj	_	_
5	as	as	RB	RB	_	4	cc	_	_
6	well	well	RB	RB	_	5	mwe	_	_
7	as	as	IN	IN	_	5	mwe	_	_
8	the	the	DT	DT	_	12	det	_	_
9	closely	closely	RB	RB	_	10	advmod	_	_
10	related	related	JJ	JJ	_	12	amod	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	Spi-B	spi-b	NN	NN	_	4	conj	_	_
13	bound	bind	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	PU-box	pu-box	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	B-cells	b-cell	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	erythroleukemia	erythroleukemia	NN	NN	_	6	compound	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	line	line	NN	NN	_	6	compound	_	_
6	K562	k562	NN	NN	_	17	nmod	_	_
7	,	,	,	,	_	17	punct	_	_
8	due	due	IN	IN	_	11	case	_	_
9	to	to	TO	TO	_	8	mwe	_	_
10	the	the	DT	DT	_	11	det	_	_
11	absence	absence	NN	NN	_	17	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Spi-B	spi-b	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	17	punct	_	_
15	only	only	RB	RB	_	16	advmod	_	_
16	PU.1	pu.1	NN	NN	_	17	nsubj	_	_
17	bound	bind	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Btk	btk	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	Mutation	mutation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	either	either	DT	DT	_	4	det	_	_
4	site	site	NN	NN	_	1	nmod	_	_
5	reduced	reduce	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	transient	transient	JJ	JJ	_	11	amod	_	_
10	transfection	transfection	NN	NN	_	11	compound	_	_
11	experiments	experiment	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	mutation	mutation	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	PU	pu	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	3	nmod	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	no	no	DT	DT	_	10	neg	_	_
10	effect	effect	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	T-cell	t-cell	NN	NN	_	15	compound	_	_
14	line	line	NN	NN	_	15	compound	_	_
15	Jurkat	jurkat	NN	NN	_	8	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	where	where	WRB	WRB	_	25	advmod	_	_
18	none	none	NN	NN	_	25	nsubjpass	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	Spi-1	spi-1	NN	NN	_	23	compound	_	_
22	family	family	NN	NN	_	23	compound	_	_
23	members	member	NNS	NNS	_	18	nmod	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	expressed	express	VBN	VBN	_	15	acl:relcl	_	_
26	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	Spi-B	spi-b	NN	NN	_	9	nsubj	_	_
4	as	as	RB	RB	_	3	cc	_	_
5	well	well	RB	RB	_	4	mwe	_	_
6	as	as	IN	IN	_	4	mwe	_	_
7	PU.1	pu.1	NN	NN	_	3	conj	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	able	able	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	transactivate	transactivate	VB	VB	_	9	xcomp	_	_
12	Btk	btk	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	fetal	fetal	JJ	JJ	_	3	amod	_	_
3	liver	liver	NN	NN	_	19	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	PU.1-/-	pu.1-/-	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	lack	lack	VBP	VBP	_	6	acl:relcl	_	_
10	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	myeloid	myeloid	JJ	JJ	_	10	conj	_	_
13	cells	cell	NNS	NNS	_	9	dobj	_	_
14	,	,	,	,	_	19	punct	_	_
15	expression	expression	NN	NN	_	19	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Btk	btk	NN	NN	_	15	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	reduced	reduce	VBN	VBN	_	0	root	_	_
20	two-	two-	CD	CD	_	19	advmod	_	_
21	to	to	TO	TO	_	20	dep	_	_
22	threefold	threefold	RB	RB	_	20	advmod	_	_
23	but	but	CC	CC	_	19	cc	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	abolished	abolish	VBN	VBN	_	19	conj	_	_
26	.	.	.	.	_	19	punct	_	_

1	Collectively	collectively	RB	RB	_	4	advmod	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	shows	show	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	expression	expression	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Btk	btk	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	combined	combined	JJ	JJ	_	16	amod	_	_
16	action	action	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Sp1-	sp1-	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	PU.1-family	pu.1-family	NN	NN	_	21	compound	_	_
21	members	member	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	Elf-1	elf-1	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Stat5	stat5	NN	NN	_	1	conj	_	_
4	bind	bind	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	critical	critical	JJ	JJ	_	8	amod	_	_
8	element	element	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	enhancer	enhancer	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	human	human	JJ	JJ	_	19	amod	_	_
16	interleukin-2	interleukin-2	NN	NN	_	19	compound	_	_
17	receptor	receptor	NN	NN	_	19	compound	_	_
18	alpha	alpha	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	12	nmod	_	_
20	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
21	published	publish	VBN	VBN	_	22	amod	_	_
22	erratum	erratum	NN	NN	_	23	nsubj	_	_
23	appears	appear	VBZ	VBZ	_	4	parataxis	_	_
24	in	in	IN	IN	_	27	case	_	_
25	Mol	Mol	NNP	NNP	_	27	compound	_	_
26	Cell	Cell	NNP	NNP	_	27	compound	_	_
27	Biol	Biol	NNP	NNP	_	23	nmod	_	_
28	1997	1997	CD	CD	_	29	nummod	_	_
29	Apr	Apr	NNP	NNP	_	27	dep	_	_
30	;	;	:	:	_	27	punct	_	_
31	17	17	CD	CD	_	33	nummod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	4	4	CD	CD	_	27	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	:	:	:	:	_	27	punct	_	_
36	2351	2351	CD	CD	_	27	dep	_	_
37	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	interleukin	interleukin	NN	NN	_	5	compound	_	_
3	2	2	CD	CD	_	5	nummod	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	alpha-chain	alpha-chain	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	IL-2R	il-2r	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	gene	gene	NN	NN	_	14	nsubj	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	key	key	JJ	JJ	_	14	amod	_	_
14	regulator	regulator	NN	NN	_	0	root	_	_
15	of	of	IN	IN	_	17	case	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	proliferation	proliferation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	IL-2R	il-2r	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	7	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	7	auxpass	_	_
4	rapidly	rapidly	RB	RB	_	5	advmod	_	_
5	and	and	CC	CC	_	7	advmod	_	_
6	potently	potently	RB	RB	_	5	advmod	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	response	response	NN	NN	_	15	dep	_	_
13	to	to	TO	TO	_	15	case	_	_
14	mitogenic	mitogenic	JJ	JJ	_	15	amod	_	_
15	stimuli	stimulus	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Interleukin	interleukin	NN	NN	_	6	nsubj	_	_
2	2	2	CD	CD	_	1	nummod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL-2	il-2	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
7	IL-2R	il-2r	NN	NN	_	9	compound	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	thereby	thereby	RB	RB	_	12	advmod	_	_
12	amplifying	amplify	VBG	VBG	_	6	advcl	_	_
13	expression	expression	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
16	own	own	JJ	JJ	_	18	amod	_	_
17	high-affinity	high-affinity	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	IL-2R	il-2r	NN	NN	_	3	compound	_	_
2	alpha	alpha	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	9	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	9	auxpass	_	_
5	at	at	IN	IN	_	8	advmod	_	_
6	least	least	JJS	JJS	_	5	mwe	_	_
7	in	in	IN	IN	_	8	case	_	_
8	part	part	NN	NN	_	9	nmod	_	_
9	controlled	control	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	two	two	CD	CD	_	14	nummod	_	_
12	positive	positive	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	regions	region	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	PRRI	prri	NN	NN	_	14	appos	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	PRRII	prrii	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	PRRI	prri	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	inducible	inducible	JJ	JJ	_	6	amod	_	_
5	proximal	proximal	JJ	JJ	_	6	amod	_	_
6	enhancer	enhancer	NN	NN	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	located	located	JJ	JJ	_	6	amod	_	_
9	between	between	IN	IN	_	10	case	_	_
10	nucleotides	nucleotide	NNS	NNS	_	8	nmod	_	_
11	-276	-276	CD	CD	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	-244	-244	CD	CD	_	11	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	contains	contain	VBZ	VBZ	_	6	acl:relcl	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	SRE/CArG	sre/carg	NN	NN	_	17	conj	_	_
20	motifs	motif	NNS	NNS	_	16	dobj	_	_
21	.	.	.	.	_	6	punct	_	_

1	PRRII	prrii	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	T-cell-specific	t-cell-specific	JJ	JJ	_	5	amod	_	_
5	enhancer	enhancer	NN	NN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	located	located	JJ	JJ	_	5	amod	_	_
8	between	between	IN	IN	_	9	case	_	_
9	nucleotides	nucleotide	NNS	NNS	_	7	nmod	_	_
10	-137	-137	CD	CD	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	-64	-64	CD	CD	_	10	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	binds	bind	VBZ	VBZ	_	5	acl:relcl	_	_
16	the	the	DT	DT	_	20	det	_	_
17	T-cell-specific	t-cell-specific	JJ	JJ	_	20	amod	_	_
18	Ets	ets	NN	NN	_	20	compound	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	Elf-1	elf-1	NN	NN	_	15	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	HMG-I(Y)	hmg-i(y)	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	none	none	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	these	these	DT	DT	_	7	det	_	_
6	proximal	proximal	JJ	JJ	_	7	amod	_	_
7	regions	region	NNS	NNS	_	3	nmod	_	_
8	account	account	VBP	VBP	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	IL-2R	il-2r	NN	NN	_	15	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	11	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IL-2	il-2	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	find	find	VB	VB	_	27	advcl	_	_
3	new	new	JJ	JJ	_	5	amod	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	regions	region	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	IL-2R	il-2r	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	27	punct	_	_
12	8.5	8.5	CD	CD	_	13	nummod	_	_
13	kb	kb	NN	NN	_	27	nsubjpass	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	5'	5'	JJ	JJ	_	19	amod	_	_
17	end	end	NN	NN	_	19	compound	_	_
18	noncoding	noncoding	JJ	JJ	_	19	amod	_	_
19	sequence	sequence	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	IL-2R	il-2r	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	19	nmod	_	_
25	have	have	VBP	VBP	_	27	aux	_	_
26	been	be	VBN	VBN	_	27	auxpass	_	_
27	sequenced	sequence	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	86-nucleotide	86-nucleotide	JJ	JJ	_	5	amod	_	_
5	fragment	fragment	NN	NN	_	2	dobj	_	_
6	that	that	WDT	WDT	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	90	90	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	10	nmod:npmod	_	_
10	identical	identical	JJ	JJ	_	5	acl:relcl	_	_
11	to	to	TO	TO	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	recently	recently	RB	RB	_	14	advmod	_	_
14	characterized	characterize	VBN	VBN	_	17	amod	_	_
15	murine	murine	JJ	JJ	_	17	amod	_	_
16	IL-2-responsive	il-2-responsive	JJ	JJ	_	17	amod	_	_
17	element	element	NN	NN	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	mIL-2rE	mil-2re	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	putative	putative	JJ	JJ	_	4	amod	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	IL-2rE	il-2re	NN	NN	_	9	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	designated	designate	VBN	VBN	_	4	acl	_	_
7	PRRIII	prriii	NN	NN	_	6	xcomp	_	_
8	,	,	,	,	_	4	punct	_	_
9	confers	confer	VBZ	VBZ	_	0	root	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	responsiveness	responsiveness	NN	NN	_	9	dobj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	heterologous	heterologous	JJ	JJ	_	15	amod	_	_
15	promoter	promoter	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	PRRIII	prriii	NN	NN	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	Stat	stat	NN	NN	_	7	compound	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	2	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	overlaps	overlap	VBZ	VBZ	_	7	acl:relcl	_	_
10	with	with	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	EBS	ebs	NN	NN	_	13	compound	_	_
13	motif	motif	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GASd/EBSd	gasd/ebsd	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	cop	_	_
3	essential	essential	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	inducibility	inducibility	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	PRRIII/CAT	prriii/cat	NN	NN	_	10	compound	_	_
9	reporter	reporter	NN	NN	_	10	compound	_	_
10	constructs	construct	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	IL-2	il-2	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	binding	binding	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	Stat5a	stat5a	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	b	b	NN	NN	_	6	conj	_	_
9	proteins	protein	NNS	NNS	_	4	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	GASd	gasd	NN	NN	_	14	compound	_	_
14	element	element	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	confirm	confirm	VB	VB	_	11	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	physiological	physiological	JJ	JJ	_	5	amod	_	_
5	relevance	relevance	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	findings	finding	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	carried	carry	VBD	VBD	_	0	root	_	_
12	out	out	RP	RP	_	11	compound:prt	_	_
13	in	in	FW	FW	_	16	amod	_	_
14	vivo	vivo	FW	FW	_	13	dep	_	_
15	footprinting	footprinting	NN	NN	_	16	compound	_	_
16	experiments	experiment	NNS	NNS	_	11	dobj	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	showed	show	VBD	VBD	_	16	acl:relcl	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	stimulation	stimulation	NN	NN	_	25	nsubj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	IL-2R	il-2r	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	nmod	_	_
25	correlated	correlate	VBD	VBD	_	18	ccomp	_	_
26	with	with	IN	IN	_	27	case	_	_
27	occupancy	occupancy	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	GASd	gasd	NN	NN	_	31	compound	_	_
31	element	element	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	major	major	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GASd/EBSd	gasd/ebsd	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	IL-2R	il-2r	NN	NN	_	14	compound	_	_
13	alpha	alpha	NN	NN	_	14	compound	_	_
14	regulation	regulation	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	suggest	suggest	VBP	VBP	_	3	conj	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	the	the	DT	DT	_	21	det	_	_
19	T-cell-specific	t-cell-specific	JJ	JJ	_	21	amod	_	_
20	Elf-1	elf-1	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	23	nsubj	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	serve	serve	VB	VB	_	16	ccomp	_	_
24	as	as	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	transcriptional	transcriptional	JJ	JJ	_	27	amod	_	_
27	repressor	repressor	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Association	association	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TRAF1	traf1	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	TRAF2	traf2	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	TRAF3	traf3	NN	NN	_	3	conj	_	_
9	with	with	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
12	virus	virus	NN	NN	_	14	compound	_	_
13	LMP1	lmp1	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	1	nmod	_	_
15	important	important	JJ	JJ	_	14	amod	_	_
16	for	for	IN	IN	_	18	case	_	_
17	B-lymphocyte	b-lymphocyte	NN	NN	_	18	compound	_	_
18	transformation	transformation	NN	NN	_	15	nmod	_	_
19	:	:	:	:	_	1	punct	_	_
20	role	role	NN	NN	_	1	dep	_	_
21	in	in	IN	IN	_	23	case	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
3	virus	virus	NN	NN	_	9	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EBV	ebv	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	transforming	transform	VBG	VBG	_	9	amod	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	LMP1	lmp1	NN	NN	_	10	nsubj	_	_
10	appears	appear	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	19	mark	_	_
12	be	be	VB	VB	_	19	cop	_	_
13	a	a	DT	DT	_	19	det	_	_
14	constitutively	constitutively	RB	RB	_	15	advmod	_	_
15	activated	activate	VBN	VBN	_	19	amod	_	_
16	tumor	tumor	NN	NN	_	19	compound	_	_
17	necrosis	necrosis	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	10	xcomp	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	TNFR	tnfr	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	on	on	IN	IN	_	29	case	_	_
24	the	the	DT	DT	_	29	dep	_	_
25	basis	basis	NN	NN	_	29	dep	_	_
26	of	of	IN	IN	_	29	case	_	_
27	an	a	DT	DT	_	29	det	_	_
28	intrinsic	intrinsic	JJ	JJ	_	29	amod	_	_
29	ability	ability	NN	NN	_	19	nmod	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	aggregate	aggregate	VB	VB	_	29	acl	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	plasma	plasma	NN	NN	_	35	compound	_	_
35	membrane	membrane	NN	NN	_	31	nmod	_	_
36	and	and	CC	CC	_	29	cc	_	_
37	an	a	DT	DT	_	38	det	_	_
38	association	association	NN	NN	_	29	conj	_	_
39	of	of	IN	IN	_	43	case	_	_
40	its	its	PRP$	PRP$	_	43	nmod:poss	_	_
41	cytoplasmic	cytoplasmic	JJ	JJ	_	43	amod	_	_
42	carboxyl	carboxyl	NN	NN	_	43	compound	_	_
43	terminus	terminus	NN	NN	_	38	nmod	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	CT	ct	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	with	with	IN	IN	_	49	case	_	_
48	TNFR-associated	tnfr-associated	JJ	JJ	_	49	amod	_	_
49	factors	factor	NNS	NNS	_	38	nmod	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	TRAFs	traf	NNS	NNS	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	EBV-transformed	ebv-transformed	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	20	nmod	_	_
9	most	most	JJS	JJS	_	20	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TRAF1	traf1	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	TRAF3	traf3	NN	NN	_	11	conj	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	5	5	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	9	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	TRAF2	traf2	NN	NN	_	16	nmod	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	associated	associate	VBN	VBN	_	3	ccomp	_	_
21	with	with	IN	IN	_	22	case	_	_
22	LMP1	lmp1	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	that	that	IN	IN	_	29	mark	_	_
25	most	most	JJS	JJS	_	29	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	LMP1	lmp1	NN	NN	_	25	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	associated	associate	VBN	VBN	_	20	conj	_	_
30	with	with	IN	IN	_	31	case	_	_
31	TRAF1	traf1	NN	NN	_	29	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	TRAF3	traf3	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	TRAF1	traf1	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	TRAF2	traf2	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	TRAF3	traf3	NN	NN	_	1	conj	_	_
7	bind	bind	VBP	VBP	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	single	single	JJ	JJ	_	11	amod	_	_
11	site	site	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	LMP1	lmp1	NN	NN	_	15	compound	_	_
15	CT	ct	NN	NN	_	11	nmod	_	_
16	corresponding	correspond	VBG	VBG	_	15	acl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	amino	amino	NN	NN	_	19	compound	_	_
19	acids	acid	NNS	NNS	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	aa	aa	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	199	199	CD	CD	_	19	dep	_	_
24	to	to	TO	TO	_	23	dep	_	_
25	214	214	CD	CD	_	23	dep	_	_
26	,	,	,	,	_	11	punct	_	_
27	within	within	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	domain	domain	NN	NN	_	11	nmod	_	_
30	which	which	WDT	WDT	_	32	nsubj	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	important	important	JJ	JJ	_	29	acl:relcl	_	_
33	for	for	IN	IN	_	36	case	_	_
34	B-lymphocyte	b-lymphocyte	NN	NN	_	36	compound	_	_
35	growth	growth	NN	NN	_	36	compound	_	_
36	transformation	transformation	NN	NN	_	32	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	aa	aa	NNS	NNS	_	29	dep	_	_
39	187	187	CD	CD	_	38	dep	_	_
40	to	to	TO	TO	_	39	dep	_	_
41	231	231	CD	CD	_	39	dep	_	_
42	)	)	-RRB-	-RRB-	_	38	punct	_	_
43	.	.	.	.	_	7	punct	_	_

1	Further	further	JJ	JJ	_	6	amod	_	_
2	deletional	deletional	JJ	JJ	_	6	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	alanine	alanine	NN	NN	_	5	compound	_	_
5	mutagenesis	mutagenesis	NN	NN	_	2	conj	_	_
6	analyses	analysis	NNS	NNS	_	26	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	comparison	comparison	NN	NN	_	6	conj	_	_
9	with	with	IN	IN	_	12	case	_	_
10	TRAF	traf	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sequences	sequence	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	CD40	cd40	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	in	in	IN	IN	_	17	case	_	_
17	CD30	cd30	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	LMP1	lmp1	NN	NN	_	14	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	other	other	JJ	JJ	_	25	amod	_	_
25	lymphycryptoviruses	lymphycryptovirus	NNS	NNS	_	22	nmod	_	_
26	provide	provide	VBP	VBP	_	0	root	_	_
27	the	the	DT	DT	_	29	det	_	_
28	first	first	JJ	JJ	_	29	amod	_	_
29	evidence	evidence	NN	NN	_	26	dobj	_	_
30	that	that	IN	IN	_	37	mark	_	_
31	PXQXT/S	pxqxt/s	NN	NN	_	37	nsubj	_	_
32	is	be	VBZ	VBZ	_	37	cop	_	_
33	a	a	DT	DT	_	37	det	_	_
34	core	core	NN	NN	_	37	compound	_	_
35	TRAF	traf	NN	NN	_	37	compound	_	_
36	binding	binding	NN	NN	_	37	compound	_	_
37	motif	motif	NN	NN	_	29	ccomp	_	_
38	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	negative	negative	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	21	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	point	point	NN	NN	_	6	compound	_	_
6	mutations	mutation	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	LMP1(1-231)	lmp1(1-231)	NN	NN	_	13	compound	_	_
10	core	core	NN	NN	_	13	compound	_	_
11	TRAF	traf	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	motif	motif	NN	NN	_	6	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	TRAF	traf	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	3	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	16	conj	_	_
20	genetically	genetically	RB	RB	_	21	advmod	_	_
21	link	link	VBP	VBP	_	0	root	_	_
22	the	the	DT	DT	_	23	det	_	_
23	TRAFs	traf	NNS	NNS	_	21	dobj	_	_
24	to	to	TO	TO	_	27	case	_	_
25	LMP1(1-231)-mediated	lmp1(1-231)-mediated	JJ	JJ	_	27	amod	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	27	compound	_	_
27	activation	activation	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	21	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	LMP1(1-231)	lmp1(1-231)	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	likely	likely	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	6	xcomp	_	_
10	by	by	IN	IN	_	12	case	_	_
11	TRAF1/TRAF2	traf1/traf2	NN	NN	_	12	compound	_	_
12	heteroaggregates	heteroaggregate	NNS	NNS	_	9	nmod	_	_
13	since	since	IN	IN	_	16	mark	_	_
14	TRAF1	traf1	NN	NN	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	unique	unique	JJ	JJ	_	9	advcl	_	_
17	among	among	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	TRAFs	traf	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	coactivating	coactivate	VBG	VBG	_	16	advcl	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	21	dobj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	LMP1(1-231)	lmp1(1-231)	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	6	punct	_	_
26	a	a	DT	DT	_	29	det	_	_
27	TRAF2	traf2	NN	NN	_	29	compound	_	_
28	dominant-negative	dominant-negative	JJ	JJ	_	29	amod	_	_
29	mutant	mutant	NN	NN	_	31	nsubj	_	_
30	can	can	MD	MD	_	31	aux	_	_
31	block	block	VB	VB	_	6	ccomp	_	_
32	LMP1(1-231)-mediated	lmp1(1-231)-mediated	JJ	JJ	_	34	amod	_	_
33	NF-kappaB	nf-kappab	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	31	dobj	_	_
35	as	as	RB	RB	_	34	cc	_	_
36	well	well	RB	RB	_	35	mwe	_	_
37	as	as	IN	IN	_	35	mwe	_	_
38	TRAF1	traf1	NN	NN	_	39	compound	_	_
39	coactivation	coactivation	NN	NN	_	34	conj	_	_
40	,	,	,	,	_	6	punct	_	_
41	and	and	CC	CC	_	6	cc	_	_
42	30	30	CD	CD	_	43	nummod	_	_
43	%	%	NN	NN	_	47	nsubjpass	_	_
44	of	of	IN	IN	_	45	case	_	_
45	TRAF2	traf2	NN	NN	_	43	nmod	_	_
46	is	be	VBZ	VBZ	_	47	auxpass	_	_
47	associated	associate	VBN	VBN	_	6	conj	_	_
48	with	with	IN	IN	_	49	case	_	_
49	TRAF1	traf1	NN	NN	_	47	nmod	_	_
50	in	in	IN	IN	_	53	case	_	_
51	EBV-transformed	ebv-transformed	JJ	JJ	_	53	amod	_	_
52	B	b	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	47	nmod	_	_
54	.	.	.	.	_	6	punct	_	_

1	TRAF3	traf3	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	modulator	modulator	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	LMP1(1-231)-mediated	lmp1(1-231)-mediated	JJ	JJ	_	9	amod	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	TRAF1	traf1	NN	NN	_	11	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	-2	-2	CD	CD	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	or	or	CC	CC	_	3	cc	_	_
8	-3	-3	CD	CD	_	3	conj	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	interact	interact	VB	VB	_	0	root	_	_
12	with	with	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	terminal	terminal	JJ	JJ	_	17	amod	_	_
15	LMP1	lmp1	NN	NN	_	17	compound	_	_
16	CT	ct	NN	NN	_	17	compound	_	_
17	aa	aa	NNS	NNS	_	11	nmod	_	_
18	333	333	CD	CD	_	17	dep	_	_
19	to	to	TO	TO	_	18	dep	_	_
20	386	386	CD	CD	_	18	dep	_	_
21	which	which	WDT	WDT	_	24	nsubj	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	independently	independently	RB	RB	_	24	advmod	_	_
24	mediate	mediate	VBP	VBP	_	17	acl:relcl	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	constitutive	constitutive	JJ	JJ	_	3	amod	_	_
3	association	association	NN	NN	_	26	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	TRAFs	traf	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	LMP1	lmp1	NN	NN	_	3	nmod	_	_
8	through	through	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	aa	aa	NNS	NNS	_	14	compound	_	_
11	187	187	CD	CD	_	14	compound	_	_
12	to	to	TO	TO	_	11	dep	_	_
13	231	231	CD	CD	_	11	dep	_	_
14	domain	domain	NN	NN	_	3	nmod	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	important	important	JJ	JJ	_	14	acl:relcl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	primary	primary	JJ	JJ	_	25	amod	_	_
23	B-lymphocyte	b-lymphocyte	NN	NN	_	25	compound	_	_
24	growth	growth	NN	NN	_	25	compound	_	_
25	transformation	transformation	NN	NN	_	20	conj	_	_
26	implicates	implicate	VBZ	VBZ	_	0	root	_	_
27	TRAF	traf	NN	NN	_	28	compound	_	_
28	aggregation	aggregation	NN	NN	_	26	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	LMP1	lmp1	NN	NN	_	31	compound	_	_
31	signaling	signaling	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	26	punct	_	_

1	CD40	cd40	NN	NN	_	8	compound	_	_
2	,	,	,	,	_	1	punct	_	_
3	but	but	CC	CC	_	4	cc	_	_
4	not	not	RB	RB	_	1	cc	_	_
5	lipopolysaccharide	lipopolysaccharide	NN	NN	_	1	conj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	anti-IgM	anti-igm	JJ	JJ	_	5	conj	_	_
8	stimulation	stimulation	NN	NN	_	14	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	leads	lead	VBZ	VBZ	_	0	root	_	_
15	to	to	TO	TO	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	persistent	persistent	JJ	JJ	_	19	amod	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	accumulation	accumulation	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	RelB	relb	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	analyzed	analyze	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CD40	cd40	NN	NN	_	10	compound	_	_
10	stimulation	stimulation	NN	NN	_	7	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	appearance	appearance	NN	NN	_	13	conj	_	_
17	of	of	IN	IN	_	24	case	_	_
18	Rel/nuclear	rel/nuclear	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	kappaB	kappab	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	factors	factor	NNS	NNS	_	13	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	primary	primary	JJ	JJ	_	29	amod	_	_
27	murine	murine	JJ	JJ	_	29	amod	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	19	mark	_	_
4	triggering	triggering	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	CD40	cd40	NN	NN	_	10	compound	_	_
7	signaling	signaling	NN	NN	_	10	compound	_	_
8	pathway	pathway	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	s	s	NNS	NNS	_	4	nmod	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	by	by	IN	IN	_	14	case	_	_
13	CD40	cd40	NN	NN	_	14	compound	_	_
14	ligands	ligand	NNS	NNS	_	4	nmod	_	_
15	expressed	express	VBN	VBN	_	14	acl	_	_
16	on	on	IN	IN	_	18	case	_	_
17	L	l	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	led	lead	VBD	VBD	_	2	ccomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	strong	strong	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	an	a	DT	DT	_	28	det	_	_
25	NF-kappaB-controlled	nf-kappab-controlled	JJ	JJ	_	28	amod	_	_
26	beta-globin	beta-globin	NN	NN	_	28	compound	_	_
27	reporter	reporter	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	22	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	primary	primary	JJ	JJ	_	32	amod	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
33	from	from	IN	IN	_	35	case	_	_
34	transgenic	transgenic	JJ	JJ	_	35	amod	_	_
35	mice	mouse	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Analyses	analysis	NNS	NNS	_	18	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	translocation	translocation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	individual	individual	JJ	JJ	_	7	amod	_	_
7	members	member	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Rel	rel	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	after	after	IN	IN	_	13	case	_	_
12	CD40	cd40	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	4	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	primary	primary	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	showed	show	VBD	VBD	_	0	root	_	_
19	a	a	DT	DT	_	23	det	_	_
20	strong	strong	JJ	JJ	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	long-lasting	long-lasting	JJ	JJ	_	20	conj	_	_
23	accumulation	accumulation	NN	NN	_	18	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	RelB	relb	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	,	,	,	,	_	29	punct	_	_
28	less	less	RBR	RBR	_	29	advmod	_	_
29	pronounced	pronounced	JJ	JJ	_	23	conj	_	_
30	,	,	,	,	_	29	punct	_	_
31	of	of	IN	IN	_	32	case	_	_
32	c-Rel	c-rel	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	18	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	give	give	VB	VB	_	0	root	_	_
6	rise	rise	NN	NN	_	5	dobj	_	_
7	to	to	TO	TO	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	persistent	persistent	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	accumulation	accumulation	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	RelB	relb	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-Rel	c-rel	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	whereas	whereas	IN	IN	_	5	dep	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	c-Rel	c-rel	NN	NN	_	25	nsubj	_	_
20	,	,	,	,	_	19	punct	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	19	cc	_	_
23	RelB	relb	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	accumulated	accumulate	VBD	VBD	_	5	parataxis	_	_
26	after	after	IN	IN	_	30	case	_	_
27	B	b	NN	NN	_	30	compound	_	_
28	cell	cell	NN	NN	_	30	compound	_	_
29	receptor	receptor	NN	NN	_	30	compound	_	_
30	stimulation	stimulation	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	CD40	cd40	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	only	only	RB	RB	_	6	cc:preconj	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	translocation	translocation	NN	NN	_	2	dobj	_	_
7	but	but	CC	CC	_	6	cc	_	_
8	also	also	RB	RB	_	11	advmod	_	_
9	de	de	FW	FW	_	11	amod	_	_
10	novo	novo	FW	FW	_	9	dep	_	_
11	synthesis	synthesis	NN	NN	_	6	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	RelB	relb	NN	NN	_	6	nmod	_	_
14	RNA	rna	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	protein	protein	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	S107	s107	NN	NN	_	3	compound	_	_
2	plasmacytoma	plasmacytoma	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	20	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	express	express	VBP	VBP	_	3	acl:relcl	_	_
7	CD40	cd40	NN	NN	_	6	dobj	_	_
8	but	but	CC	CC	_	6	cc	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	defective	defective	JJ	JJ	_	6	conj	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	appearance	appearance	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	p50/p65-NF-kappaB	p50/p65-nf-kappab	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	do	do	VBP	VBP	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	express	express	VB	VB	_	0	root	_	_
21	RelB	relb	NN	NN	_	20	dobj	_	_
22	after	after	IN	IN	_	24	case	_	_
23	CD40	cd40	NN	NN	_	24	compound	_	_
24	stimulation	stimulation	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	S107	s107	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	18	nmod	_	_
4	stably	stably	RB	RB	_	5	advmod	_	_
5	transfected	transfect	VBN	VBN	_	3	acl	_	_
6	with	with	IN	IN	_	8	case	_	_
7	relB	relb	NN	NN	_	8	compound	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	18	punct	_	_
10	stimulation	stimulation	NN	NN	_	18	nsubjpass	_	_
11	of	of	IN	IN	_	14	case	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	RelB	relb	NN	NN	_	14	compound	_	_
14	translocation	translocation	NN	NN	_	10	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	CD40	cd40	NN	NN	_	10	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	observed	observe	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	CD40	cd40	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	5	nmod	_	_
10	exerts	exert	VBZ	VBZ	_	3	ccomp	_	_
11	a	a	DT	DT	_	14	det	_	_
12	long-lasting	long-lasting	JJ	JJ	_	14	amod	_	_
13	stimulatory	stimulatory	JJ	JJ	_	14	amod	_	_
14	effect	effect	NN	NN	_	10	dobj	_	_
15	on	on	IN	IN	_	18	case	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	transcription	transcription	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	translocation	translocation	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	RelB	relb	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	LPS	lps	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	anti-IgM	anti-igm	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	unable	unable	JJ	JJ	_	12	advcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	activate	activate	VB	VB	_	6	xcomp	_	_
9	RelB	relb	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	12	punct	_	_
11	CD40	cd40	NN	NN	_	12	nsubj	_	_
12	appears	appear	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	trigger	trigger	VB	VB	_	12	xcomp	_	_
15	a	a	DT	DT	_	17	det	_	_
16	special	special	JJ	JJ	_	17	amod	_	_
17	program	program	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	involved	involve	VBN	VBN	_	17	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	proliferation	proliferation	NN	NN	_	21	nmod	_	_
25	and/or	and/or	CC	CC	_	24	cc	_	_
26	differentiation	differentiation	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Sterol	sterol	NN	NN	_	2	nmod:npmod	_	_
2	dependent	dependent	JJ	JJ	_	5	amod	_	_
3	LDL-receptor	ldl-receptor	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
8	from	from	IN	IN	_	12	case	_	_
9	normal	normal	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CML	cml	NN	NN	_	9	conj	_	_
12	patients	patient	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Sterol	sterol	NN	NN	_	3	compound	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	SRE	sre	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	recognized	recognize	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	regulate	regulate	VB	VB	_	9	xcomp	_	_
12	various	various	JJ	JJ	_	14	amod	_	_
13	key	key	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	11	dobj	_	_
15	coding	code	VBG	VBG	_	14	acl	_	_
16	for	for	IN	IN	_	24	case	_	_
17	especially	especially	RB	RB	_	18	advmod	_	_
18	low	low	JJ	JJ	_	24	amod	_	_
19	density	density	NN	NN	_	24	compound	_	_
20	lipoprotein	lipoprotein	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	LDL	ldl	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	-receptor	-receptor	NN	NN	_	15	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	NN	NN	_	28	compound	_	_
27	coenzyme	coenzyme	NN	NN	_	28	compound	_	_
28	A	a	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	HMG-CoA	hmg-coa	NN	NN	_	32	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	reductase	reductase	NN	NN	_	24	conj	_	_
33	and	and	CC	CC	_	24	cc	_	_
34	HMG-CoA	hmg-coa	NN	NN	_	35	compound	_	_
35	synthase	synthase	NN	NN	_	24	conj	_	_
36	known	know	VBN	VBN	_	24	acl	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	play	play	VB	VB	_	36	xcomp	_	_
39	a	a	DT	DT	_	41	det	_	_
40	crucial	crucial	JJ	JJ	_	41	amod	_	_
41	role	role	NN	NN	_	38	dobj	_	_
42	in	in	IN	IN	_	46	case	_	_
43	the	the	DT	DT	_	46	det	_	_
44	cholesterol	cholesterol	NN	NN	_	46	compound	_	_
45	feedback	feedback	NN	NN	_	46	compound	_	_
46	mechanism	mechanism	NN	NN	_	38	nmod	_	_
47	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	deranged	deranged	JJ	JJ	_	5	amod	_	_
3	cholesterol	cholesterol	NN	NN	_	5	compound	_	_
4	feedback	feedback	NN	NN	_	5	compound	_	_
5	mechanism	mechanism	NN	NN	_	9	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	9	aux	_	_
7	been	be	VBN	VBN	_	9	auxpass	_	_
8	widely	widely	RB	RB	_	9	advmod	_	_
9	recognised	recognise	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	initiation	initiation	NN	NN	_	9	nmod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	progression	progression	NN	NN	_	11	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	various	various	JJ	JJ	_	18	amod	_	_
18	types	type	NNS	NNS	_	11	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cancers	cancer	NNS	NNS	_	18	nmod	_	_
21	including	include	VBG	VBG	_	24	case	_	_
22	chronic	chronic	JJ	JJ	_	24	amod	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	leukaemia	leukaemia	NN	NN	_	18	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CML	cml	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	9	punct	_	_

1	Consequently	consequently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	present	present	JJ	JJ	_	5	amod	_	_
5	study	study	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	addressed	address	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	understand	understand	VB	VB	_	7	xcomp	_	_
10	this	this	DT	DT	_	11	det	_	_
11	phenomenon	phenomenon	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	revealed	reveal	VBD	VBD	_	7	conj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	existence	existence	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	22	case	_	_
17	a	a	DT	DT	_	22	det	_	_
18	unique	unique	JJ	JJ	_	22	amod	_	_
19	47	47	CD	CD	_	20	compound	_	_
20	kDa	kda	NN	NN	_	22	amod	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	15	nmod	_	_
23	having	have	VBG	VBG	_	22	acl	_	_
24	affinity	affinity	NN	NN	_	23	dobj	_	_
25	for	for	IN	IN	_	28	case	_	_
26	this	this	DT	DT	_	28	det	_	_
27	SRE	sre	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	24	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
31	from	from	IN	IN	_	33	case	_	_
32	normal	normal	JJ	JJ	_	33	amod	_	_
33	subjects	subject	NNS	NNS	_	30	nmod	_	_
34	as	as	RB	RB	_	15	cc	_	_
35	well	well	RB	RB	_	34	mwe	_	_
36	as	as	IN	IN	_	34	mwe	_	_
37	its	its	PRP$	PRP$	_	38	nmod:poss	_	_
38	absence	absence	NN	NN	_	15	conj	_	_
39	in	in	IN	IN	_	40	case	_	_
40	lymphocytes	lymphocyte	NNS	NNS	_	38	nmod	_	_
41	from	from	IN	IN	_	44	case	_	_
42	untreated	untreated	JJ	JJ	_	44	amod	_	_
43	CML	cml	NN	NN	_	44	compound	_	_
44	patients	patient	NNS	NNS	_	40	nmod	_	_
45	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	factor	factor	NN	NN	_	5	nsubj	_	_
5	appeared	appear	VBD	VBD	_	0	root	_	_
6	when	when	WRB	WRB	_	10	advmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CML	cml	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	10	nsubj	_	_
10	achieved	achieve	VBD	VBD	_	5	advcl	_	_
11	complete	complete	JJ	JJ	_	13	amod	_	_
12	haematological	haematological	JJ	JJ	_	13	amod	_	_
13	remission	remission	NN	NN	_	10	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CHR	chr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	through	through	IN	IN	_	19	case	_	_
18	alpha-interferon	alpha-interferon	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Further	further	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	inverse	inverse	NN	NN	_	5	compound	_	_
5	relationship	relationship	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	between	between	IN	IN	_	14	case	_	_
10	sterol	sterol	NN	NN	_	11	nmod:npmod	_	_
11	modulated	modulated	JJ	JJ	_	14	amod	_	_
12	LDL-receptor	ldl-receptor	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	affinity	affinity	NN	NN	_	14	conj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	this	this	DT	DT	_	23	det	_	_
21	47	47	CD	CD	_	22	compound	_	_
22	kDa	kda	NN	NN	_	23	amod	_	_
23	factor	factor	NN	NN	_	18	nmod	_	_
24	to	to	TO	TO	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	SRE	sre	NN	NN	_	27	compound	_	_
27	sequence	sequence	NN	NN	_	18	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	upon	upon	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	6	advcl	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	propose	propose	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	alpha-interferon	alpha-interferon	NN	NN	_	12	nsubj	_	_
9	through	through	IN	IN	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	receptor	receptor	NN	NN	_	12	nmod	_	_
12	initiates	initiate	VBZ	VBZ	_	6	ccomp	_	_
13	phosphatidic	phosphatidic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	15	nmod:npmod	_	_
15	dependent	dependent	JJ	JJ	_	16	amod	_	_
16	signalling	signalling	NN	NN	_	12	dobj	_	_
17	which	which	WDT	WDT	_	20	nsubj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	turn	turn	NN	NN	_	20	nmod	_	_
20	regulates	regulate	VBZ	VBZ	_	16	acl:relcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	affinity	affinity	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	30	case	_	_
24	47	47	CD	CD	_	25	compound	_	_
25	kDa	kda	NN	NN	_	30	amod	_	_
26	sterol	sterol	NN	NN	_	30	compound	_	_
27	regulatory	regulatory	JJ	JJ	_	30	amod	_	_
28	element	element	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	factor	factor	NN	NN	_	22	nmod	_	_
31	as	as	RB	RB	_	22	cc	_	_
32	well	well	RB	RB	_	31	mwe	_	_
33	as	as	IN	IN	_	31	mwe	_	_
34	LDL-receptor	ldl-receptor	NN	NN	_	36	compound	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	transcription	transcription	NN	NN	_	22	conj	_	_
37	in	in	IN	IN	_	38	case	_	_
38	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
39	from	from	IN	IN	_	41	case	_	_
40	CML	cml	NN	NN	_	41	compound	_	_
41	patients	patient	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	6	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Ara-C	ara-c	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	neutral	neutral	JJ	JJ	_	6	amod	_	_
6	sphingomyelinase	sphingomyelinase	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	mitogen-	mitogen-	NN	NN	_	12	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	stress-activated	stress-activated	JJ	JJ	_	8	conj	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	kinases	kinase	NNS	NNS	_	6	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	T-lymphocyte	t-lymphocyte	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	6	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Neutral	neutral	JJ	JJ	_	2	amod	_	_
2	sphingomyelinase	sphingomyelinase	NN	NN	_	8	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	SMase	smase	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	extracellular	extracellular	JJ	JJ	_	11	amod	_	_
11	signals	signal	NNS	NNS	_	8	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	produce	produce	VB	VB	_	8	xcomp	_	_
14	ceramide	ceramide	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	affect	affect	VB	VB	_	14	acl:relcl	_	_
19	mitogen-activated	mitogen-activated	JJ	JJ	_	21	amod	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	kinase	kinase	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	MAPK	mapk	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	activities	activity	NNS	NNS	_	18	dobj	_	_
26	.	.	.	.	_	8	punct	_	_

1	Neutral	neutral	JJ	JJ	_	3	amod	_	_
2	SMase	smase	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	assessed	assess	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	membranes	membrane	NNS	NNS	_	5	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	Jurkat	jurkat	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	9	appos	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	EL4	el4	NN	NN	_	9	conj	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	22	det	_	_
20	murine	murine	JJ	JJ	_	22	amod	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	17	appos	_	_
23	.	.	.	.	_	5	punct	_	_

1	Ara-C	ara-c	NN	NN	_	2	nsubj	_	_
2	activated	activate	VBD	VBD	_	0	root	_	_
3	SMase	smase	NN	NN	_	2	dobj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	10	10	CD	CD	_	6	nummod	_	_
6	minutes	minute	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	Jurkat	jurkat	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	EL4	el4	NN	NN	_	9	conj	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	while	while	IN	IN	_	20	mark	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester	ester	NN	NN	_	20	nsubj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PMA	pma	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	had	have	VBD	VBD	_	2	advcl	_	_
21	no	no	DT	DT	_	22	neg	_	_
22	effect	effect	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	2	punct	_	_

1	PMA	pma	NN	NN	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	but	but	CC	CC	_	4	cc	_	_
4	not	not	RB	RB	_	1	cc	_	_
5	Ara-C	ara-c	NN	NN	_	1	conj	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	ceramides	ceramide	NNS	NNS	_	5	conj	_	_
8	,	,	,	,	_	1	punct	_	_
9	activated	activate	VBD	VBD	_	0	root	_	_
10	ERK	erk	NN	NN	_	11	compound	_	_
11	MAPKS	mapk	NNS	NNS	_	9	dobj	_	_
12	,	,	,	,	_	9	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	Jurkat	jurkat	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	EL4	el4	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	PMA	pma	NN	NN	_	2	nsubj	_	_
2	acted	act	VBD	VBD	_	0	root	_	_
3	synergistically	synergistically	RB	RB	_	2	advmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	ionomycin	ionomycin	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VB	VB	_	2	xcomp	_	_
8	JNK	jnk	NN	NN	_	9	compound	_	_
9	MAPKs	mapk	NNS	NNS	_	7	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	Jurkat	jurkat	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	EL4	el4	NN	NN	_	11	conj	_	_
14	within	within	IN	IN	_	16	case	_	_
15	10	10	CD	CD	_	16	nummod	_	_
16	minutes	minute	NNS	NNS	_	7	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Ara-C	ara-c	NN	NN	_	2	nsubj	_	_
2	activated	activate	VBD	VBD	_	0	root	_	_
3	JNKs	jnk	NNS	NNS	_	2	dobj	_	_
4	only	only	RB	RB	_	7	advmod	_	_
5	after	after	IN	IN	_	7	case	_	_
6	prolonged	prolonged	JJ	JJ	_	7	amod	_	_
7	incubation	incubation	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	90-120	90-120	CD	CD	_	10	nummod	_	_
10	minutes	minute	NNS	NNS	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	.	.	.	.	_	2	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	ceramide	ceramide	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	not	not	RB	RB	_	8	neg	_	_
6	a	a	DT	DT	_	8	det	_	_
7	positive	positive	JJ	JJ	_	8	amod	_	_
8	signal	signal	NN	NN	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	ERK	erk	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Ara-C	ara-c	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	JNK	jnk	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	nmod	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	0	root	_	_
11	through	through	IN	IN	_	14	case	_	_
12	secondary	secondary	JJ	JJ	_	14	amod	_	_
13	response	response	NN	NN	_	14	compound	_	_
14	pathways	pathway	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	Cortisone-resistant	cortisone-resistant	JJ	JJ	_	4	amod	_	_
3	bronchial	bronchial	JJ	JJ	_	4	amod	_	_
4	asthma	asthma	NN	NN	_	0	root	_	_
5	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	general	general	JJ	JJ	_	4	amod	_	_
4	agreement	agreement	NN	NN	_	2	nsubj	_	_
5	on	on	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	inflammatory	inflammatory	JJ	JJ	_	8	amod	_	_
8	pathogenesis	pathogenesis	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	bronchial	bronchial	JJ	JJ	_	11	amod	_	_
11	asthma	asthma	NN	NN	_	8	nmod	_	_
12	:	:	:	:	_	2	punct	_	_
13	an	a	DT	DT	_	14	det	_	_
14	accumulation	accumulation	NN	NN	_	35	nsubjpass	_	_
15	of	of	IN	IN	_	17	case	_	_
16	activated	activate	VBN	VBN	_	17	amod	_	_
17	eosinophils	eosinophil	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	degranulated	degranulate	VBN	VBN	_	21	amod	_	_
20	mast	mast	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	conj	_	_
22	,	,	,	,	_	14	punct	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	14	conj	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	in	in	IN	IN	_	29	case	_	_
27	very	very	RB	RB	_	28	advmod	_	_
28	severe	severe	JJ	JJ	_	29	amod	_	_
29	forms	form	NNS	NNS	_	31	nmod	_	_
30	,	,	,	,	_	31	punct	_	_
31	granulocytes	granulocyte	NNS	NNS	_	14	conj	_	_
32	has	have	VBZ	VBZ	_	35	aux	_	_
33	constantly	constantly	RB	RB	_	35	advmod	_	_
34	been	be	VBN	VBN	_	35	auxpass	_	_
35	found	find	VBN	VBN	_	2	parataxis	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	bronchial	bronchial	JJ	JJ	_	39	amod	_	_
39	mucosa	mucosa	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	35	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	allergic	allergic	JJ	JJ	_	4	amod	_	_
3	bronchial	bronchial	JJ	JJ	_	4	amod	_	_
4	asthma	asthma	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	inflammation	inflammation	NN	NN	_	7	nsubj	_	_
7	seems	seem	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	orchestrated	orchestrate	VBN	VBN	_	7	xcomp	_	_
11	predominantly	predominantly	RB	RB	_	14	advmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	subset	subset	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	with	with	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	phenotype	phenotype	NN	NN	_	14	nmod	_	_
22	similar	similar	JJ	JJ	_	21	amod	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	Th2	th2	NN	NN	_	26	compound	_	_
26	subset	subset	NN	NN	_	22	nmod	_	_
27	able	able	JJ	JJ	_	26	amod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	produce	produce	VB	VB	_	27	xcomp	_	_
30	IL-4	il-4	NN	NN	_	29	dobj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	IL-5	il-5	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	8	mark	_	_
2	corticosteroids	corticosteroid	NNS	NNS	_	8	nsubj	_	_
3	are	be	VBP	VBP	_	8	cop	_	_
4	the	the	DT	DT	_	8	det	_	_
5	most	most	RBS	RBS	_	6	advmod	_	_
6	potent	potent	JJ	JJ	_	8	amod	_	_
7	therapeutic	therapeutic	JJ	JJ	_	8	amod	_	_
8	agents	agent	NNS	NNS	_	17	advcl	_	_
9	used	use	VBN	VBN	_	8	acl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	disease	disease	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
15	anti-inflammatory	anti-inflammatory	JJ	JJ	_	16	amod	_	_
16	effect	effect	NN	NN	_	17	nsubj	_	_
17	differs	differ	VBZ	VBZ	_	0	root	_	_
18	from	from	IN	IN	_	19	case	_	_
19	patient	patient	NN	NN	_	17	nmod	_	_
20	to	to	TO	TO	_	21	case	_	_
21	patient	patient	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	criteria	criterion	NNS	NNS	_	13	nsubjpass	_	_
3	which	which	WDT	WDT	_	6	nsubjpass	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	2	acl:relcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	define	define	VB	VB	_	6	xcomp	_	_
9	steroid-resistant	steroid-resistant	JJ	JJ	_	11	amod	_	_
10	bronchial	bronchial	JJ	JJ	_	11	amod	_	_
11	asthma	asthma	NN	NN	_	8	dobj	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	listed	list	VBN	VBN	_	0	root	_	_
14	here	here	RB	RB	_	13	advmod	_	_
15	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	analyzes	analyze	VBZ	VBZ	_	0	root	_	_
4	various	various	JJ	JJ	_	6	amod	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	alterations	alteration	NNS	NNS	_	3	dobj	_	_
7	responsible	responsible	JJ	JJ	_	6	amod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	deficient	deficient	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	corticosteroid	corticosteroid	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	11	nmod	_	_
15	observed	observe	VBN	VBN	_	11	acl	_	_
16	in	in	IN	IN	_	20	case	_	_
17	steroid-resistant	steroid-resistant	JJ	JJ	_	19	amod	_	_
18	bronchial	bronchial	JJ	JJ	_	19	amod	_	_
19	asthmatic	asthmatic	JJ	JJ	_	20	amod	_	_
20	subjects	subject	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	New	new	JJ	JJ	_	2	amod	_	_
2	knowledge	knowledge	NN	NN	_	10	nsubj	_	_
3	on	on	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mechanism	mechanism	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	steroid	steroid	NN	NN	_	8	compound	_	_
8	resistance	resistance	NN	NN	_	5	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	have	have	VB	VB	_	0	root	_	_
11	important	important	JJ	JJ	_	12	amod	_	_
12	implications	implication	NNS	NNS	_	10	dobj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	chronic	chronic	JJ	JJ	_	18	amod	_	_
18	asthma	asthma	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	other	other	JJ	JJ	_	21	amod	_	_
21	diseases	disease	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	Expression	expression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Egr-1	egr-1	NN	NN	_	1	nmod	_	_
4	correlates	correlate	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transformed	transform	VBN	VBN	_	8	amod	_	_
8	phenotype	phenotype	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	type	type	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	latency	latency	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	21	case	_	_
16	EBV	ebv	NN	NN	_	17	compound	_	_
17	genome	genome	NN	NN	_	18	nmod:npmod	_	_
18	positive	positive	JJ	JJ	_	21	amod	_	_
19	lymphoid	lymphoid	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	8	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	investigated	investigate	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Egr-1	egr-1	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	B	b	NN	NN	_	15	compound	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	regulation	regulation	NN	NN	_	8	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	examining	examine	VBG	VBG	_	6	advcl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	panel	panel	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	B	b	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lines	line	NNS	NNS	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	including	include	VBG	VBG	_	38	case	_	_
30	both	both	CC	CC	_	33	cc:preconj	_	_
31	EBV	ebv	NN	NN	_	32	compound	_	_
32	genome	genome	NN	NN	_	33	nmod:npmod	_	_
33	negative	negative	JJ	JJ	_	38	amod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	EBV	ebv	NN	NN	_	36	dep	_	_
36	carrying	carry	VBG	VBG	_	33	conj	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	lines	line	NNS	NNS	_	27	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	Egr-1	egr-1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	correlates	correlate	VBZ	VBZ	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	phenotype	phenotype	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	pattern	pattern	NN	NN	_	7	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	latency	latency	NN	NN	_	11	nmod	_	_
15	established	establish	VBN	VBN	_	7	acl	_	_
16	within	within	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	individual	individual	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	constitutive	constitutive	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Egr-1	egr-1	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	invariably	invariably	RB	RB	_	10	advmod	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	unrestricted	unrestricted	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	viral	viral	JJ	JJ	_	17	amod	_	_
16	latent	latent	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	26	case	_	_
19	all	all	DT	DT	_	26	det	_	_
20	group	group	NN	NN	_	26	compound	_	_
21	III	iii	CD	CD	_	26	nummod	_	_
22	EBV	ebv	NN	NN	_	23	compound	_	_
23	genome	genome	NN	NN	_	24	dep	_	_
24	carrying	carry	VBG	VBG	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	13	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	Egr-1	egr-1	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	abrogated	abrogate	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	group	group	NN	NN	_	13	compound	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	Burkitt	burkitt	NN	NN	_	13	compound	_	_
12	tumor	tumor	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	irrespective	irrespective	JJ	JJ	_	7	advmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	EBV	ebv	NN	NN	_	21	compound	_	_
19	genome	genome	NN	NN	_	21	compound	_	_
20	carrying	carrying	NN	NN	_	21	compound	_	_
21	status	status	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Activated	activate	VBN	VBN	_	4	amod	_	_
2	viral	viral	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	20	nsubj	_	_
5	associated	associate	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	8	case	_	_
7	phenotypic	phenotypic	JJ	JJ	_	8	amod	_	_
8	conversion	conversion	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	group	group	NN	NN	_	13	compound	_	_
11	I	i	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	to	to	TO	TO	_	16	case	_	_
16	group	group	NN	NN	_	8	nmod	_	_
17	II	ii	CD	CD	_	16	dep	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	III	iii	CD	CD	_	17	conj	_	_
20	restores	restore	VBZ	VBZ	_	0	root	_	_
21	the	the	DT	DT	_	24	det	_	_
22	Egr-1	egr-1	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	20	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	forms	form	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	EGR-1	egr-1	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	within	within	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	groups	group	NNS	NNS	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	25	nsubjpass	_	_
20	to	to	TO	TO	_	23	case	_	_
21	DNA	dna	NN	NN	_	23	compound	_	_
22	consensus	consensus	NN	NN	_	23	compound	_	_
23	sequences	sequence	NNS	NNS	_	19	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	investigated	investigate	VBN	VBN	_	7	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	Finally	finally	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	time	time	NN	NN	_	5	compound	_	_
4	course	course	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	18	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Egr-1	egr-1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	during	during	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	steps	step	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	EBV	ebv	NN	NN	_	15	compound	_	_
15	infection	infection	NN	NN	_	12	nmod	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vitro	vitro	FW	FW	_	15	advmod	_	_
18	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	Egr-1	egr-1	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	upregulated	upregulate	VBN	VBN	_	18	ccomp	_	_
23	within	within	IN	IN	_	24	case	_	_
24	minutes	minute	NNS	NNS	_	22	nmod	_	_
25	from	from	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	initial	initial	JJ	JJ	_	28	amod	_	_
28	interaction	interaction	NN	NN	_	24	nmod	_	_
29	with	with	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	lymphocyte	lymphocyte	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	proximal	proximal	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	interferon-gamma	interferon-gamma	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	nmod	_	_
9	mediates	mediate	VBZ	VBZ	_	0	root	_	_
10	selective	selective	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	6	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	produced	produce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	natural	natural	JJ	JJ	_	10	amod	_	_
9	killer	killer	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	certain	certain	JJ	JJ	_	13	amod	_	_
13	subsets	subset	NNS	NNS	_	10	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	but	but	CC	CC	_	6	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	basis	basis	NN	NN	_	26	nsubj	_	_
21	for	for	IN	IN	_	24	case	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	selective	selective	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	20	nmod	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	unknown	unknown	JJ	JJ	_	6	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	14	nmod	_	_
4	between	between	IN	IN	_	9	case	_	_
5	-108	-108	CD	CD	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	-40	-40	CD	CD	_	5	conj	_	_
8	base	base	NN	NN	_	9	compound	_	_
9	pairs	pair	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IFN-gamma	ifn-gamma	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	are	be	VBP	VBP	_	0	root	_	_
15	two	two	CD	CD	_	20	nummod	_	_
16	conserved	conserve	VBN	VBN	_	20	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	essential	essential	JJ	JJ	_	16	conj	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	14	nsubj	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	confer	confer	VBP	VBP	_	20	acl:relcl	_	_
24	activation-specific	activation-specific	JJ	JJ	_	25	amod	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	3	nsubj	_	_
3	describes	describe	VBZ	VBZ	_	0	root	_	_
4	studies	study	NNS	NNS	_	3	dobj	_	_
5	indicating	indicate	VBG	VBG	_	4	acl	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	most	most	RBS	RBS	_	9	advmod	_	_
9	proximal	proximal	JJ	JJ	_	18	nsubj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	these	these	DT	DT	_	14	det	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	elements	element	NNS	NNS	_	9	nmod	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	an	a	DT	DT	_	18	det	_	_
17	important	important	JJ	JJ	_	18	amod	_	_
18	determinant	determinant	NN	NN	_	5	ccomp	_	_
19	of	of	IN	IN	_	22	case	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	restricted	restricted	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proximal	proximal	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	composite	composite	JJ	JJ	_	7	amod	_	_
7	site	site	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
10	members	member	NNS	NNS	_	9	dobj	_	_
11	of	of	IN	IN	_	19	case	_	_
12	the	the	DT	DT	_	19	det	_	_
13	CREB/ATF	creb/atf	NN	NN	_	19	compound	_	_
14	,	,	,	,	_	13	punct	_	_
15	AP-1	ap-1	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	octamer	octamer	NN	NN	_	13	conj	_	_
19	families	family	NNS	NNS	_	10	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Jun	jun	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	essential	essential	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	activation-induced	activation-induced	JJ	JJ	_	6	amod	_	_
6	transcription	transcription	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	binds	bind	VBZ	VBZ	_	3	conj	_	_
9	preferably	preferably	RB	RB	_	8	advmod	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	heterodimer	heterodimer	NN	NN	_	8	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	ATF-2	atf-2	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	CREB	creb	NN	NN	_	5	nsubj	_	_
5	appears	appear	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	dampen	dampen	VB	VB	_	5	xcomp	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	from	from	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	element	element	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CpG	cpg	NN	NN	_	3	compound	_	_
3	dinucleotide	dinucleotide	NN	NN	_	9	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	element	element	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	selectively	selectively	RB	RB	_	9	advmod	_	_
9	methylated	methylate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Th2	th2	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	other	other	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	that	that	WDT	WDT	_	20	nsubj	_	_
18	do	do	VBP	VBP	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	express	express	VB	VB	_	16	acl:relcl	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	20	dobj	_	_
22	,	,	,	,	_	9	punct	_	_
23	and	and	CC	CC	_	9	cc	_	_
24	methylation	methylation	NN	NN	_	26	nsubj	_	_
25	markedly	markedly	RB	RB	_	26	advmod	_	_
26	reduces	reduce	VBZ	VBZ	_	9	conj	_	_
27	transcription	transcription	NN	NN	_	29	compound	_	_
28	factor	factor	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	9	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	target	target	NN	NN	_	21	nmod	_	_
4	for	for	IN	IN	_	6	case	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	methylation	methylation	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	for	for	IN	IN	_	9	case	_	_
9	binding	binding	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	mediate	mediate	VBP	VBP	_	12	acl:relcl	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	impede	impede	VBP	VBP	_	14	conj	_	_
17	transcription	transcription	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	21	punct	_	_
19	this	this	DT	DT	_	20	det	_	_
20	element	element	NN	NN	_	21	nsubj	_	_
21	appears	appear	VBZ	VBZ	_	0	root	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	play	play	VB	VB	_	21	xcomp	_	_
24	a	a	DT	DT	_	26	det	_	_
25	central	central	JJ	JJ	_	26	amod	_	_
26	role	role	NN	NN	_	23	dobj	_	_
27	in	in	IN	IN	_	28	mark	_	_
28	controlling	control	VBG	VBG	_	23	advcl	_	_
29	IFN-gamma	ifn-gamma	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	28	dobj	_	_
31	.	.	.	.	_	21	punct	_	_

1	Activation	activation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factor-kappaB	factor-kappab	NN	NN	_	1	nmod	_	_
5	via	via	IN	IN	_	8	case	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	1	nmod	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	15	det	_	_
11	Raf	raf	NN	NN	_	12	compound	_	_
12	kinase	kinase	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Ca2+	ca2+	NN	NN	_	12	conj	_	_
15	influx	influx	NN	NN	_	9	dobj	_	_
16	.	.	.	.	_	9	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	synergy	synergy	NN	NN	_	0	root	_	_
3	between	between	IN	IN	_	4	case	_	_
4	Raf	raf	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	calcineurin	calcineurin	NN	NN	_	4	conj	_	_
7	.	.	.	.	_	2	punct	_	_

1	Signals	signal	NNS	NNS	_	6	nsubj	_	_
2	transduced	transduce	VBN	VBN	_	1	acl	_	_
3	via	via	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	TCR	tcr	NN	NN	_	2	nmod	_	_
6	activate	activate	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	6	dobj	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor-kappaB	factor-kappab	NN	NN	_	9	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	9	punct	_	_
16	which	which	WDT	WDT	_	22	nsubj	_	_
17	,	,	,	,	_	22	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	turn	turn	NN	NN	_	22	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	critical	critical	JJ	JJ	_	9	acl:relcl	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	induction	induction	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	many	many	JJ	JJ	_	29	amod	_	_
29	genes	gene	NNS	NNS	_	26	nmod	_	_
30	important	important	JJ	JJ	_	29	amod	_	_
31	for	for	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	proliferation	proliferation	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	expression	expression	NN	NN	_	33	conj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	differentiated	differentiate	VBN	VBN	_	39	amod	_	_
39	phenotype	phenotype	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	Treatment	treatment	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	protein	protein	NN	NN	_	11	compound	_	_
8	kinase	kinase	NN	NN	_	11	compound	_	_
9	C	c	NN	NN	_	11	compound	_	_
10	activator	activator	NN	NN	_	11	compound	_	_
11	PMA	pma	NN	NN	_	1	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	combination	combination	NN	NN	_	1	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	Ca2+	ca2+	NN	NN	_	16	compound	_	_
16	ionophores	ionophore	NNS	NNS	_	13	nmod	_	_
17	mimics	mimic	VBZ	VBZ	_	0	root	_	_
18	this	this	DT	DT	_	19	det	_	_
19	process	process	NN	NN	_	17	dobj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	two	two	CD	CD	_	24	nummod	_	_
24	agents	agent	NNS	NNS	_	27	nsubjpass	_	_
25	are	be	VBP	VBP	_	27	auxpass	_	_
26	often	often	RB	RB	_	27	advmod	_	_
27	substituted	substitute	VBN	VBN	_	17	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	TCR	tcr	NN	NN	_	30	compound	_	_
30	stimulation	stimulation	NN	NN	_	27	nmod	_	_
31	,	,	,	,	_	27	punct	_	_
32	bypassing	bypass	VBG	VBG	_	27	advcl	_	_
33	the	the	DT	DT	_	34	det	_	_
34	TCR	tcr	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
5	signaling	signal	VBG	VBG	_	6	amod	_	_
6	components	component	NNS	NNS	_	3	dobj	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	nmod	_	_
12	following	follow	VBG	VBG	_	14	case	_	_
13	TCR	tcr	NN	NN	_	14	compound	_	_
14	stimulation	stimulation	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	TCR	tcr	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	triggered	trigger	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	treating	treat	VBG	VBG	_	4	advcl	_	_
7	Jurkat	jurkat	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	dobj	_	_
10	with	with	IN	IN	_	14	case	_	_
11	PHA	pha	NN	NN	_	14	compound	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	anti-CD3	anti-cd3	JJ	JJ	_	11	conj	_	_
14	Abs	ab	NNS	NNS	_	6	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	monitored	monitor	VBN	VBN	_	4	conj	_	_
21	by	by	IN	IN	_	25	case	_	_
22	electrophoretic	electrophoretic	JJ	JJ	_	25	amod	_	_
23	mobility	mobility	NN	NN	_	25	compound	_	_
24	shift	shift	NN	NN	_	25	compound	_	_
25	assays	assay	NNS	NNS	_	20	nmod	_	_
26	and/or	and/or	CC	CC	_	25	cc	_	_
27	by	by	IN	IN	_	30	case	_	_
28	kappaB-dependent	kappab-dependent	JJ	JJ	_	30	amod	_	_
29	reporter	reporter	NN	NN	_	30	compound	_	_
30	assays	assay	NNS	NNS	_	25	conj	_	_
31	.	.	.	.	_	4	punct	_	_

1	Contrary	contrary	JJ	JJ	_	4	case	_	_
2	to	to	TO	TO	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	idea	idea	NN	NN	_	23	nmod	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	protein	protein	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	C	c	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	4	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	TCR-mediated	tcr-mediated	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	23	punct	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	doses	dose	NNS	NNS	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	staurosporine	staurosporine	NN	NN	_	18	nmod	_	_
21	did	do	VBD	VBD	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	interfere	interfere	VB	VB	_	0	root	_	_
24	with	with	IN	IN	_	25	case	_	_
25	activation	activation	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	25	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	PHA	pha	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	23	punct	_	_
31	while	while	IN	IN	_	38	mark	_	_
32	the	the	DT	DT	_	34	det	_	_
33	same	same	JJ	JJ	_	34	amod	_	_
34	dose	dose	NN	NN	_	38	nsubj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	staurosporine	staurosporine	NN	NN	_	34	nmod	_	_
37	completely	completely	RB	RB	_	38	advmod	_	_
38	blocked	block	VBD	VBD	_	23	advcl	_	_
39	activation	activation	NN	NN	_	38	dobj	_	_
40	by	by	IN	IN	_	41	case	_	_
41	PMA	pma	NN	NN	_	39	nmod	_	_
42	.	.	.	.	_	23	punct	_	_

1	PHA-induced	pha-induced	JJ	JJ	_	4	amod	_	_
2	kappaB-dependent	kappab-dependent	JJ	JJ	_	4	amod	_	_
3	reporter	reporter	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	10	nsubjpass	_	_
5	was	be	VBD	VBD	_	10	auxpass	_	_
6	,	,	,	,	_	10	punct	_	_
7	however	however	RB	RB	_	10	advmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	effectively	effectively	RB	RB	_	10	advmod	_	_
10	blocked	block	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	dominant	dominant	JJ	JJ	_	15	amod	_	_
14	negative	negative	JJ	JJ	_	15	amod	_	_
15	form	form	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Raf-1	raf-1	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	critical	critical	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	for	for	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	Raf	raf	NN	NN	_	26	compound	_	_
26	kinase	kinase	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TCR-mediated	tcr-mediated	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	on	on	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	Ca2+	ca2+	NN	NN	_	12	compound	_	_
12	influx	influx	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	because	because	IN	IN	_	34	mark	_	_
15	the	the	DT	DT	_	18	det	_	_
16	Ca2+	ca2+	NN	NN	_	18	compound	_	_
17	channel	channel	NN	NN	_	18	compound	_	_
18	blocker	blocker	NN	NN	_	34	nsubj	_	_
19	,	,	,	,	_	18	punct	_	_
20	SK&amp;F	sk&amp;f	NN	NN	_	18	appos	_	_
21	96365	96365	CD	CD	_	20	nummod	_	_
22	,	,	,	,	_	18	punct	_	_
23	as	as	RB	RB	_	18	cc	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	as	as	IN	IN	_	23	mwe	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	agents	agent	NNS	NNS	_	18	conj	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	prevented	prevent	VBD	VBD	_	27	acl:relcl	_	_
30	the	the	DT	DT	_	32	det	_	_
31	Ca2+	ca2+	NN	NN	_	32	compound	_	_
32	influx	influx	NN	NN	_	29	dobj	_	_
33	,	,	,	,	_	18	punct	_	_
34	inhibited	inhibit	VBD	VBD	_	8	advcl	_	_
35	NF-kappaB	nf-kappab	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	8	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	constitutively	constitutively	RB	RB	_	5	advmod	_	_
5	active	active	JJ	JJ	_	6	amod	_	_
6	form	form	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	calcineurin	calcineurin	NN	NN	_	6	nmod	_	_
9	largely	largely	RB	RB	_	10	advmod	_	_
10	substituted	substitute	VBD	VBD	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	Ca2+	ca2+	NN	NN	_	14	compound	_	_
14	requirement	requirement	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	reversed	reverse	VBD	VBD	_	10	conj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	blockade	blockade	NN	NN	_	16	dobj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	SK&amp;F	sk&amp;f	NN	NN	_	18	nmod	_	_
21	96365	96365	CD	CD	_	20	nummod	_	_
22	.	.	.	.	_	10	punct	_	_

1	Consistent	consistent	JJ	JJ	_	16	dep	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	observations	observation	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	coexpression	coexpression	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	active	active	JJ	JJ	_	10	amod	_	_
10	forms	form	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Raf-1	raf-1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	calcineurin	calcineurin	NN	NN	_	12	conj	_	_
15	synergistically	synergistically	RB	RB	_	16	advmod	_	_
16	induced	induce	VBD	VBD	_	0	root	_	_
17	kappaB-dependent	kappab-dependent	JJ	JJ	_	19	amod	_	_
18	reporter	reporter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	16	punct	_	_
21	suggesting	suggest	VBG	VBG	_	16	advcl	_	_
22	a	a	DT	DT	_	26	det	_	_
23	physiologically	physiologically	RB	RB	_	24	advmod	_	_
24	relevant	relevant	JJ	JJ	_	26	amod	_	_
25	functional	functional	JJ	JJ	_	26	amod	_	_
26	interaction	interaction	NN	NN	_	21	dobj	_	_
27	between	between	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	kinase	kinase	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	32	det	_	_
32	phosphatase	phosphatase	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	16	punct	_	_

1	Induction	induction	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CD11b	cd11b	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	during	during	IN	IN	_	7	case	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	line	line	NN	NN	_	13	compound	_	_
13	U937	u937	NN	NN	_	7	nmod	_	_
14	requires	require	VBZ	VBZ	_	0	root	_	_
15	a	a	DT	DT	_	19	det	_	_
16	novel	novel	JJ	JJ	_	19	amod	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	MS-2	ms-2	NN	NN	_	14	dobj	_	_
20	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
21	published	publish	VBN	VBN	_	22	amod	_	_
22	erratum	erratum	NN	NN	_	23	nsubj	_	_
23	appears	appear	VBZ	VBZ	_	14	parataxis	_	_
24	in	in	IN	IN	_	26	case	_	_
25	J	J	NNP	NNP	_	26	compound	_	_
26	Immunol	Immunol	NNP	NNP	_	23	nmod	_	_
27	1999	1999	CD	CD	_	28	nummod	_	_
28	Jul	Jul	NNP	NNP	_	26	dep	_	_
29	15	15	CD	CD	_	28	nummod	_	_
30	;	;	:	:	_	26	punct	_	_
31	163	163	CD	CD	_	33	nummod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	2	2	CD	CD	_	26	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	:	:	:	:	_	26	punct	_	_
36	1091	1091	CD	CD	_	26	dep	_	_
37	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	differentiation	differentiation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	myeloid	myeloid	JJ	JJ	_	5	amod	_	_
5	precursors	precursor	NNS	NNS	_	2	nmod	_	_
6	into	into	IN	IN	_	9	case	_	_
7	mature	mature	JJ	JJ	_	9	amod	_	_
8	myelomonocytic	myelomonocytic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	characterized	characterize	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	gene	gene	NN	NN	_	14	nmod	_	_
18	encoding	encode	VBG	VBG	_	17	acl	_	_
19	the	the	DT	DT	_	22	det	_	_
20	beta2	beta2	NN	NN	_	22	compound	_	_
21	integrin	integrin	NN	NN	_	22	compound	_	_
22	CD11b	cd11b	NN	NN	_	18	dobj	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	7	nsubj	_	_
4	Sp1	sp1	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	PU.1	pu.1	NN	NN	_	4	conj	_	_
7	prime	prime	VBP	VBP	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD11b	cd11b	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	but	but	CC	CC	_	7	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	nature	nature	NN	NN	_	24	nsubj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	responsible	responsible	JJ	JJ	_	17	amod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	inducible	inducible	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	are	be	VBP	VBP	_	24	cop	_	_
24	unknown	unknown	JJ	JJ	_	7	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	addition	addition	NN	NN	_	6	dep	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD11b	cd11b	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	16	nmod	_	_
7	,	,	,	,	_	16	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	homologous	homologous	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	16	nsubj	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	CD11a	cd11a	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	CD11c	cd11c	NN	NN	_	12	conj	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	exhibit	exhibit	VBP	VBP	_	0	root	_	_
17	inducible	inducible	JJ	JJ	_	18	amod	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	during	during	IN	IN	_	21	case	_	_
20	myeloid	myeloid	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	compared	compare	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nucleotide	nucleotide	JJ	JJ	_	7	amod	_	_
7	sequences	sequence	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	CD11a	cd11a	NN	NN	_	17	compound	_	_
11	,	,	,	,	_	10	punct	_	_
12	CD11b	cd11b	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	CD11c	cd11c	NN	NN	_	10	conj	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	promoters	promoter	NNS	NNS	_	7	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	identify	identify	VB	VB	_	4	advcl	_	_
20	common	common	JJ	JJ	_	21	amod	_	_
21	elements	element	NNS	NNS	_	19	dobj	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	might	might	MD	MD	_	24	aux	_	_
24	contribute	contribute	VB	VB	_	21	acl:relcl	_	_
25	to	to	TO	TO	_	27	case	_	_
26	inducible	inducible	JJ	JJ	_	27	amod	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	one	one	CD	CD	_	6	nummod	_	_
5	such	such	JJ	JJ	_	6	amod	_	_
6	element	element	NN	NN	_	3	dobj	_	_
7	repeated	repeat	VBN	VBN	_	6	acl	_	_
8	four	four	CD	CD	_	9	nummod	_	_
9	times	time	NNS	NNS	_	7	dobj	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD11b	cd11b	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Mutation	mutation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	elements	element	NNS	NNS	_	1	nmod	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	two	two	CD	CD	_	14	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	MS-2beta	ms-2beta	NN	NN	_	7	appos	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	MS-2gamma	ms-2gamma	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	critical	critical	JJ	JJ	_	5	ccomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CD11b	cd11b	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	during	during	IN	IN	_	23	case	_	_
23	differentiation	differentiation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	pro-monocytic	pro-monocytic	JJ	JJ	_	29	amod	_	_
27	cell	cell	NN	NN	_	29	compound	_	_
28	line	line	NN	NN	_	29	compound	_	_
29	U937	u937	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	MS-2beta	ms-2beta	NN	NN	_	10	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	MS-2gamma	ms-2gamma	NN	NN	_	7	conj	_	_
10	interact	interact	VBP	VBP	_	5	ccomp	_	_
11	with	with	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	13	acl:relcl	_	_
17	during	during	IN	IN	_	19	case	_	_
18	U937	u937	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	factors	factor	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	at	at	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	time	time	NN	NN	_	4	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD11b	cd11b	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	activated	activate	VBN	VBN	_	7	acl:relcl	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mass	mass	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	approximately	approximately	RB	RB	_	9	advmod	_	_
9	28	28	CD	CD	_	10	nummod	_	_
10	kDa	kda	NN	NN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	characteristics	characteristic	NNS	NNS	_	18	nsubj	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	indistinguishable	indistinguishable	JJ	JJ	_	10	conj	_	_
19	from	from	IN	IN	_	20	case	_	_
20	those	those	DT	DT	_	18	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	novel	novel	JJ	JJ	_	26	amod	_	_
24	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
25	factor	factor	NN	NN	_	26	compound	_	_
26	MS-2	ms-2	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	MS-2	ms-2	NN	NN	_	9	nsubj	_	_
9	mediates	mediate	VBZ	VBZ	_	6	ccomp	_	_
10	induction	induction	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD11b	cd11b	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	as	as	IN	IN	_	21	mark	_	_
16	cells	cell	NNS	NNS	_	21	nsubj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
20	lineage	lineage	NN	NN	_	16	nmod	_	_
21	mature	mature	VBP	VBP	_	9	advcl	_	_
22	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	25	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	multiple	multiple	JJ	JJ	_	7	amod	_	_
5	potential	potential	JJ	JJ	_	7	amod	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	sites	site	NNS	NNS	_	2	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	MS-2	ms-2	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	regions	region	NNS	NNS	_	2	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	wide	wide	JJ	JJ	_	17	amod	_	_
17	range	range	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	genes	gene	NNS	NNS	_	17	nmod	_	_
20	expressed	express	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	mature	mature	JJ	JJ	_	24	amod	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	suggests	suggest	VBZ	VBZ	_	0	root	_	_
26	this	this	DT	DT	_	27	det	_	_
27	factor	factor	NN	NN	_	28	nsubj	_	_
28	plays	play	VBZ	VBZ	_	25	ccomp	_	_
29	a	a	DT	DT	_	31	det	_	_
30	general	general	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	myeloid	myeloid	JJ	JJ	_	34	amod	_	_
34	differentiation	differentiation	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	25	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	3	compound	_	_
2	LTR	ltr	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	10	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	CD40-activated	cd40-activated	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	0	root	_	_
11	on	on	IN	IN	_	12	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	CD40-stimulated	cd40-stimulated	JJ	JJ	_	4	amod	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	7	nsubj	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	permissive	permissive	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	productive	productive	JJ	JJ	_	11	amod	_	_
11	infection	infection	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
16	virus	virus	NN	NN	_	17	compound	_	_
17	type	type	NN	NN	_	11	nmod	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	26	nmod	_	_
4	,	,	,	,	_	26	punct	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	26	nsubj	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	LTR	ltr	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	contains	contain	VBZ	VBZ	_	13	acl:relcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
19	control	control	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	16	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	virus	virus	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	are	be	VBP	VBP	_	26	cop	_	_
26	unknown	unknown	JJ	JJ	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	18	nsubj	_	_
4	with	with	IN	IN	_	5	case	_	_
5	plasmids	plasmid	NNS	NNS	_	3	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	deleted	delete	VBN	VBN	_	8	amod	_	_
8	parts	part	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	LTR	ltr	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	8	nmod	_	_
13	linked	link	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	showed	show	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	the	the	DT	DT	_	23	det	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	25	nsubj	_	_
24	was	be	VBD	VBD	_	25	cop	_	_
25	essential	essential	JJ	JJ	_	18	ccomp	_	_
26	for	for	IN	IN	_	29	case	_	_
27	HIV-1	hiv-1	NN	NN	_	29	compound	_	_
28	LTR	ltr	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	25	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	CD40-stimulated	cd40-stimulated	JJ	JJ	_	33	amod	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	electrophoretic	electrophoretic	JJ	JJ	_	6	amod	_	_
5	mobility	mobility	NN	NN	_	6	compound	_	_
6	shift	shift	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	supershift	supershift	NN	NN	_	6	conj	_	_
9	assays	assay	NNS	NNS	_	10	nsubj	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	29	mark	_	_
12	important	important	JJ	JJ	_	15	amod	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	29	nsubj	_	_
16	composed	compose	VBN	VBN	_	15	acl	_	_
17	of	of	IN	IN	_	27	case	_	_
18	at	at	IN	IN	_	19	case	_	_
19	least	least	JJS	JJS	_	27	advmod	_	_
20	p50	p50	NN	NN	_	27	compound	_	_
21	,	,	,	,	_	20	punct	_	_
22	p65	p65	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	c-Rel	c-rel	NN	NN	_	26	compound	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	20	conj	_	_
27	subunits	subunit	NNS	NNS	_	16	nmod	_	_
28	was	be	VBD	VBD	_	29	cop	_	_
29	present	present	JJ	JJ	_	10	ccomp	_	_
30	in	in	IN	IN	_	31	case	_	_
31	nuclei	nucleus	NNS	NNS	_	29	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	CD40-stimulated	cd40-stimulated	JJ	JJ	_	35	amod	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	confirm	confirm	VBP	VBP	_	0	root	_	_
4	at	at	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	level	level	NN	NN	_	3	nmod	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	3	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	HIV-1	hiv-1	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	replicate	replicate	VB	VB	_	9	acl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	this	this	DT	DT	_	20	det	_	_
20	activity	activity	NN	NN	_	23	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	strongly	strongly	RB	RB	_	23	advmod	_	_
23	associated	associate	VBN	VBN	_	3	conj	_	_
24	with	with	IN	IN	_	25	case	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Mutation	mutation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	tyrosines	tyrosine	NNS	NNS	_	1	nmod	_	_
4	492/493	492/493	CD	CD	_	3	nummod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	ZAP-70	zap-70	NN	NN	_	8	nmod	_	_
11	affects	affect	VBZ	VBZ	_	0	root	_	_
12	multiple	multiple	JJ	JJ	_	16	amod	_	_
13	T-cell	t-cell	NN	NN	_	16	compound	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	11	dobj	_	_
17	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	protein-tyrosine	protein-tyrosine	JJ	JJ	_	4	amod	_	_
3	kinase	kinase	NN	NN	_	4	compound	_	_
4	ZAP-70	zap-70	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	implicated	implicate	VBN	VBN	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	together	together	RB	RB	_	13	advmod	_	_
9	with	with	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	Src	src	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	p56(lck)	p56(lck)	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	controlling	control	VBG	VBG	_	6	advcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	early	early	JJ	JJ	_	19	amod	_	_
19	steps	step	NNS	NNS	_	16	dobj	_	_
20	of	of	IN	IN	_	29	case	_	_
21	the	the	DT	DT	_	29	det	_	_
22	T-cell	t-cell	NN	NN	_	24	compound	_	_
23	antigen	antigen	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	TCR	tcr	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	signaling	signaling	NN	NN	_	29	compound	_	_
29	cascade	cascade	NN	NN	_	19	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	help	help	VB	VB	_	16	advcl	_	_
3	elucidate	elucidate	VB	VB	_	2	ccomp	_	_
4	further	further	RBR	RBR	_	3	advmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	10	nmod	_	_
9	ZAP-70	zap-70	NN	NN	_	10	nsubj	_	_
10	regulates	regulate	VBZ	VBZ	_	6	acl:relcl	_	_
11	these	these	DT	DT	_	13	det	_	_
12	initial	initial	JJ	JJ	_	13	amod	_	_
13	events	event	NNS	NNS	_	10	dobj	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	used	use	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	20	det	_	_
18	dominant-negative	dominant-negative	JJ	JJ	_	20	amod	_	_
19	mutant	mutant	NN	NN	_	20	compound	_	_
20	approach	approach	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	overexpressed	overexpress	VBD	VBD	_	0	root	_	_
3	in	in	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	Jurkat	jurkat	NN	NN	_	7	compound	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	2	nmod	_	_
8	ZAP-70	zap-70	NN	NN	_	2	dobj	_	_
9	mutated	mutate	VBN	VBN	_	8	acl	_	_
10	on	on	IN	IN	_	11	case	_	_
11	Tyr-492	tyr-492	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Tyr-493	tyr-493	NN	NN	_	11	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	putative	putative	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	loop	loop	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	domain	domain	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	mutant	mutant	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	TCR-induced	tcr-induced	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	activated	activate	VBN	VBN	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	interfering	interfere	VBG	VBG	_	3	advcl	_	_
15	with	with	IN	IN	_	19	case	_	_
16	both	both	CC	CC	_	19	cc:preconj	_	_
17	intracellular	intracellular	JJ	JJ	_	19	amod	_	_
18	calcium	calcium	NN	NN	_	19	compound	_	_
19	increase	increase	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Ras-regulated	ras-regulated	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	19	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	extracellular	extracellular	JJ	JJ	_	26	amod	_	_
25	signal-regulated	signal-regulated	JJ	JJ	_	26	amod	_	_
26	kinases	kinase	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	TCR-induced	tcr-induced	JJ	JJ	_	4	amod	_	_
4	phosphorylation	phosphorylation	NN	NN	_	19	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	pp36-38	pp36-38	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	thought	think	VBN	VBN	_	4	acl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	play	play	VB	VB	_	8	xcomp	_	_
11	a	a	DT	DT	_	12	det	_	_
12	role	role	NN	NN	_	10	dobj	_	_
13	upstream	upstream	RB	RB	_	10	advmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	pathways	pathway	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	reduced	reduce	VBN	VBN	_	19	xcomp	_	_
23	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	overexpression	overexpression	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	wild-type	wild-type	JJ	JJ	_	7	amod	_	_
7	ZAP-70	zap-70	NN	NN	_	4	nmod	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	constitutive	constitutive	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factor	factor	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ZAP-70	zap-70	NN	NN	_	3	compound	_	_
3	mutant	mutant	NN	NN	_	8	nsubjpass	_	_
4	studied	study	VBN	VBN	_	3	acl	_	_
5	here	here	RB	RB	_	4	advmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
9	on	on	IN	IN	_	10	case	_	_
10	tyrosine	tyrosine	NN	NN	_	8	nmod	_	_
11	when	when	WRB	WRB	_	12	advmod	_	_
12	associated	associate	VBN	VBN	_	8	advcl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	TCR	tcr	NN	NN	_	17	compound	_	_
16	zeta	zeta	NN	NN	_	17	compound	_	_
17	chain	chain	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	able	able	JJ	JJ	_	8	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	bind	bind	VB	VB	_	20	xcomp	_	_
23	p56(lck)	p56(lck)	NN	NN	_	22	dobj	_	_
24	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	Tyr-492	tyr-492	NN	NN	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Tyr-493	tyr-493	NN	NN	_	5	conj	_	_
8	are	be	VBP	VBP	_	10	cop	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
11	for	for	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	Src	src	NN	NN	_	16	nmod:npmod	_	_
14	homology	homology	NN	NN	_	16	nmod:npmod	_	_
15	domain	domain	NN	NN	_	16	nmod:npmod	_	_
16	2-mediated	2-mediated	JJ	JJ	_	17	amod	_	_
17	association	association	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	p56(lck)	p56(lck)	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	ZAP-70	zap-70	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	consistent	consistent	JJ	JJ	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	model	model	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	15	nmod	_	_
11	recruitment	recruitment	NN	NN	_	15	nsubj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	TCR	tcr	NN	NN	_	11	nmod	_	_
15	allows	allow	VBZ	VBZ	_	8	acl:relcl	_	_
16	ZAP-70	zap-70	NN	NN	_	15	dobj	_	_
17	autophosphorylation	autophosphorylation	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	binding	binding	NN	NN	_	17	conj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	p56(lck)	p56(lck)	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	which	which	WDT	WDT	_	26	nsubj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	turn	turn	NN	NN	_	26	nmod	_	_
26	phosphorylates	phosphorylate	VBZ	VBZ	_	16	acl:relcl	_	_
27	Tyr-492	tyr-492	NN	NN	_	26	dobj	_	_
28	and/or	and/or	CC	CC	_	27	cc	_	_
29	Tyr-493	tyr-493	NN	NN	_	27	conj	_	_
30	with	with	IN	IN	_	32	case	_	_
31	consequent	consequent	JJ	JJ	_	32	amod	_	_
32	up-regulation	up-regulation	NN	NN	_	26	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	ZAP-70	zap-70	NN	NN	_	37	compound	_	_
36	kinase	kinase	NN	NN	_	37	compound	_	_
37	activity	activity	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	ZAP-70	zap-70	NN	NN	_	5	nsubj	_	_
2	will	will	MD	MD	_	5	aux	_	_
3	then	then	RB	RB	_	5	advmod	_	_
4	be	be	VB	VB	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	effectively	effectively	RB	RB	_	8	advmod	_	_
8	control	control	VB	VB	_	5	xcomp	_	_
9	phosphorylation	phosphorylation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	substrates	substrate	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	lead	lead	VB	VB	_	8	conj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	3	compound	_	_
2	suppression	suppression	NN	NN	_	3	compound	_	_
3	test	test	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	corticosteroid	corticosteroid	NN	NN	_	7	compound	_	_
6	receptors	receptor	NNS	NNS	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	3	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	young	young	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	aged	aged	JJ	JJ	_	12	conj	_	_
15	subjects	subject	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	dexamethasone	dexamethasone	NN	NN	_	4	compound	_	_
3	suppression	suppression	NN	NN	_	4	compound	_	_
4	test	test	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	DST	dst	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	considered	consider	VBN	VBN	_	0	root	_	_
10	an	a	DT	DT	_	11	det	_	_
11	indicator	indicator	NN	NN	_	9	xcomp	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	function	function	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	adrenal	adrenal	JJ	JJ	_	19	amod	_	_
18	pituitary	pituitary	JJ	JJ	_	19	amod	_	_
19	axis	axis	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	steroid	steroid	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
10	binding	binding	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	corticosteroid	corticosteroid	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	measurement	measurement	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	corticosteroid	corticosteroid	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	an	a	DT	DT	_	14	det	_	_
14	index	index	NN	NN	_	3	ccomp	_	_
15	of	of	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	analogous	analogous	JJ	JJ	_	18	amod	_	_
18	pattern	pattern	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	brain	brain	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	corticosteroid	corticosteroid	NN	NN	_	12	compound	_	_
7	Type	type	NN	NN	_	12	compound	_	_
8	I	i	CD	CD	_	7	nummod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	Type	type	NN	NN	_	7	conj	_	_
11	II	ii	CD	CD	_	10	nummod	_	_
12	receptors	receptor	NNS	NNS	_	17	nsubjpass	_	_
13	in	in	IN	IN	_	15	case	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	leukocytes	leukocyte	NNS	NNS	_	12	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	measured	measure	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	10	10	CD	CD	_	21	nummod	_	_
20	elderly	elderly	JJ	JJ	_	21	amod	_	_
21	subjects	subject	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	in	in	IN	IN	_	26	case	_	_
24	9	9	CD	CD	_	26	nummod	_	_
25	young	young	JJ	JJ	_	26	amod	_	_
26	adults	adult	NNS	NNS	_	21	conj	_	_
27	,	,	,	,	_	17	punct	_	_
28	before	before	IN	IN	_	32	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	after	after	IN	IN	_	28	conj	_	_
31	overnight	overnight	JJ	JJ	_	32	amod	_	_
32	DST	dst	NN	NN	_	17	nmod	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	1	1	CD	CD	_	35	nummod	_	_
35	mg	mg	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	17	punct	_	_

1	Receptors	receptor	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	measured	measure	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	radioreceptor	radioreceptor	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	3	nmod	_	_
7	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	all	all	PDT	PDT	_	4	det:predet	_	_
3	the	the	DT	DT	_	4	det	_	_
4	subjects	subject	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	dexamethasone	dexamethasone	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	able	able	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	suppress	suppress	VB	VB	_	8	xcomp	_	_
11	plasma	plasma	NN	NN	_	12	compound	_	_
12	cortisol	cortisol	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	Type	type	NN	NN	_	9	compound	_	_
5	I	i	CD	CD	_	4	nummod	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	Type	type	NN	NN	_	4	conj	_	_
8	II	ii	CD	CD	_	7	nummod	_	_
9	receptors	receptor	NNS	NNS	_	2	nmod	_	_
10	before	before	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	test	test	NN	NN	_	2	nmod	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	lower	lower	JJR	JJR	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	elderly	elderly	JJ	JJ	_	17	amod	_	_
17	subjects	subject	NNS	NNS	_	14	nmod	_	_
18	than	than	IN	IN	_	20	case	_	_
19	in	in	IN	IN	_	20	case	_	_
20	adults	adult	NNS	NNS	_	14	advcl	_	_
21	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	control	control	NN	NN	_	4	compound	_	_
4	group	group	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	dexamethasone	dexamethasone	NN	NN	_	7	nsubj	_	_
7	produced	produce	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	depression	depression	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	Type	type	NN	NN	_	14	compound	_	_
13	I	i	CD	CD	_	14	nummod	_	_
14	receptors	receptor	NNS	NNS	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	10	punct	_	_
16	from	from	IN	IN	_	17	case	_	_
17	267	267	CD	CD	_	10	nmod	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	72	72	CD	CD	_	17	conj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	169	169	CD	CD	_	10	nmod	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	71	71	CD	CD	_	21	conj	_	_
24	receptors	receptor	NNS	NNS	_	10	dep	_	_
25	per	per	IN	IN	_	26	case	_	_
26	cell	cell	NN	NN	_	24	nmod	_	_
27	)	)	-RRB-	-RRB-	_	10	punct	_	_
28	,	,	,	,	_	10	punct	_	_
29	which	which	WDT	WDT	_	32	nsubjpass	_	_
30	can	can	MD	MD	_	32	aux	_	_
31	be	be	VB	VB	_	32	auxpass	_	_
32	interpreted	interpret	VBN	VBN	_	10	acl:relcl	_	_
33	as	as	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	primary	primary	JJ	JJ	_	36	amod	_	_
36	involvement	involvement	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	Type	type	NN	NN	_	40	compound	_	_
39	I	i	CD	CD	_	40	nummod	_	_
40	receptors	receptor	NNS	NNS	_	36	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	response	response	NN	NN	_	36	nmod	_	_
44	to	to	TO	TO	_	45	case	_	_
45	dexamethasone	dexamethasone	NN	NN	_	43	nmod	_	_
46	;	;	:	:	_	7	punct	_	_
47	Type	type	NN	NN	_	49	compound	_	_
48	II	ii	CD	CD	_	49	nummod	_	_
49	receptors	receptor	NNS	NNS	_	50	nsubj	_	_
50	decreased	decrease	VBD	VBD	_	7	parataxis	_	_
51	in	in	IN	IN	_	54	case	_	_
52	half	half	PDT	PDT	_	54	det:predet	_	_
53	the	the	DT	DT	_	54	det	_	_
54	subjects	subject	NNS	NNS	_	50	nmod	_	_
55	(	(	-LRB-	-LRB-	_	50	punct	_	_
56	from	from	IN	IN	_	57	case	_	_
57	2849	2849	CD	CD	_	50	nmod	_	_
58	+/-	+/-	CC	CC	_	57	cc	_	_
59	703	703	CD	CD	_	57	conj	_	_
60	to	to	TO	TO	_	61	case	_	_
61	2345	2345	CD	CD	_	50	nmod	_	_
62	+/-	+/-	CC	CC	_	61	cc	_	_
63	569	569	CD	CD	_	61	conj	_	_
64	receptors	receptor	NNS	NNS	_	50	dobj	_	_
65	per	per	IN	IN	_	66	case	_	_
66	cell	cell	NN	NN	_	64	nmod	_	_
67	)	)	-RRB-	-RRB-	_	50	punct	_	_
68	.	.	.	.	_	50	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	elderly	elderly	JJ	JJ	_	4	amod	_	_
3	healthy	healthy	JJ	JJ	_	4	amod	_	_
4	subjects	subject	NNS	NNS	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	Type	type	NN	NN	_	8	compound	_	_
7	II	ii	CD	CD	_	8	nummod	_	_
8	receptors	receptor	NNS	NNS	_	12	nsubjpass	_	_
9	were	be	VBD	VBD	_	12	auxpass	_	_
10	also	also	RB	RB	_	12	advmod	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	decreased	decrease	VBN	VBN	_	0	root	_	_
13	(	(	-LRB-	-LRB-	_	12	punct	_	_
14	from	from	IN	IN	_	15	case	_	_
15	1796	1796	CD	CD	_	12	nmod	_	_
16	+/-	+/-	CC	CC	_	15	cc	_	_
17	671	671	CD	CD	_	15	conj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	720	720	CD	CD	_	12	nmod	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	345	345	CD	CD	_	19	conj	_	_
22	)	)	-RRB-	-RRB-	_	12	punct	_	_
23	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	young	young	JJ	JJ	_	6	amod	_	_
6	subjects	subject	NNS	NNS	_	12	nmod	_	_
7	Type	type	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	receptors	receptor	NNS	NNS	_	12	nsubjpass	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	initially	initially	RB	RB	_	12	advmod	_	_
12	up-regulated	up-regulate	VBN	VBN	_	2	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	then	then	RB	RB	_	18	advmod	_	_
18	down-regulated	down-regulate	VBN	VBN	_	12	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	while	while	IN	IN	_	29	mark	_	_
21	in	in	RB	RB	_	23	advmod	_	_
22	aged	aged	JJ	JJ	_	23	amod	_	_
23	subjects	subject	NNS	NNS	_	29	nmod	_	_
24	an	a	DT	DT	_	25	det	_	_
25	up-regulation	up-regulation	NN	NN	_	29	nsubjpass	_	_
26	can	can	MD	MD	_	29	aux	_	_
27	not	not	RB	RB	_	29	neg	_	_
28	be	be	VB	VB	_	29	auxpass	_	_
29	achieved	achieve	VBN	VBN	_	12	advcl	_	_
30	,	,	,	,	_	29	punct	_	_
31	as	as	IN	IN	_	32	mark	_	_
32	suggested	suggest	VBN	VBN	_	29	advcl	_	_
33	by	by	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	higher	higher	JJR	JJR	_	36	amod	_	_
36	values	value	NNS	NNS	_	32	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	plasma	plasma	NN	NN	_	39	compound	_	_
39	cortisol	cortisol	NN	NN	_	36	nmod	_	_
40	usually	usually	RB	RB	_	41	advmod	_	_
41	found	find	VBN	VBN	_	36	acl	_	_
42	in	in	IN	IN	_	44	case	_	_
43	aging	age	VBG	VBG	_	44	amod	_	_
44	subjects	subject	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	2	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	5	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	CML	cml	NN	NN	_	4	compound	_	_
4	patients	patient	NNS	NNS	_	1	nmod	_	_
5	lack	lack	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	47	47	CD	CD	_	8	compound	_	_
8	kDa	kda	NN	NN	_	9	amod	_	_
9	factor	factor	NN	NN	_	5	dobj	_	_
10	having	have	VBG	VBG	_	9	acl	_	_
11	affinity	affinity	NN	NN	_	10	dobj	_	_
12	for	for	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	genomic	genomic	JJ	JJ	_	17	amod	_	_
15	sterol	sterol	NN	NN	_	17	compound	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	sequence	sequence	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Deranged	derange	VBN	VBN	_	4	amod	_	_
2	cellular	cellular	JJ	JJ	_	4	amod	_	_
3	cholesterol	cholesterol	NN	NN	_	4	compound	_	_
4	homeostasis	homeostasis	NN	NN	_	8	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	been	be	VBN	VBN	_	8	auxpass	_	_
7	widely	widely	RB	RB	_	8	advmod	_	_
8	recognized	recognize	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	initiation	initiation	NN	NN	_	8	nmod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	progression	progression	NN	NN	_	11	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	various	various	JJ	JJ	_	18	amod	_	_
18	types	type	NNS	NNS	_	11	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cancers	cancer	NNS	NNS	_	18	nmod	_	_
21	including	include	VBG	VBG	_	24	case	_	_
22	chronic	chronic	JJ	JJ	_	24	amod	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	leukaemia	leukaemia	NN	NN	_	18	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CML	cml	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	13	mark	_	_
2	the	the	DT	DT	_	7	det	_	_
3	human	human	JJ	JJ	_	7	amod	_	_
4	genomic	genomic	JJ	JJ	_	7	amod	_	_
5	sterol	sterol	NN	NN	_	7	compound	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	13	nsubjpass	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	SRE	sre	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	shown	show	VBN	VBN	_	27	advcl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	regulate	regulate	VB	VB	_	13	xcomp	_	_
16	various	various	JJ	JJ	_	18	amod	_	_
17	key	key	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	15	dobj	_	_
19	involved	involve	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	this	this	DT	DT	_	22	det	_	_
22	phenomenon	phenomenon	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	27	punct	_	_
24	the	the	DT	DT	_	26	det	_	_
25	present	present	JJ	JJ	_	26	amod	_	_
26	study	study	NN	NN	_	27	nsubj	_	_
27	revealed	reveal	VBD	VBD	_	0	root	_	_
28	the	the	DT	DT	_	29	det	_	_
29	existence	existence	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	36	case	_	_
31	a	a	DT	DT	_	36	det	_	_
32	unique	unique	JJ	JJ	_	36	amod	_	_
33	47	47	CD	CD	_	34	compound	_	_
34	kDa	kda	NN	NN	_	36	amod	_	_
35	protein	protein	NN	NN	_	36	compound	_	_
36	factor	factor	NN	NN	_	29	nmod	_	_
37	having	have	VBG	VBG	_	36	acl	_	_
38	affinity	affinity	NN	NN	_	37	dobj	_	_
39	for	for	IN	IN	_	42	case	_	_
40	this	this	DT	DT	_	42	det	_	_
41	SRE	sre	JJ	JJ	_	42	amod	_	_
42	sequence	sequence	NN	NN	_	38	nmod	_	_
43	in	in	IN	IN	_	44	case	_	_
44	lymphocytes	lymphocyte	NNS	NNS	_	29	nmod	_	_
45	from	from	IN	IN	_	47	case	_	_
46	normal	normal	JJ	JJ	_	47	amod	_	_
47	subjects	subject	NNS	NNS	_	44	nmod	_	_
48	,	,	,	,	_	29	punct	_	_
49	as	as	RB	RB	_	29	cc	_	_
50	well	well	RB	RB	_	49	mwe	_	_
51	as	as	IN	IN	_	49	mwe	_	_
52	its	its	PRP$	PRP$	_	53	nmod:poss	_	_
53	absence	absence	NN	NN	_	29	conj	_	_
54	in	in	IN	IN	_	55	case	_	_
55	lymphocytes	lymphocyte	NNS	NNS	_	53	nmod	_	_
56	from	from	IN	IN	_	59	case	_	_
57	untreated	untreated	JJ	JJ	_	59	amod	_	_
58	CML	cml	NN	NN	_	59	compound	_	_
59	patients	patient	NNS	NNS	_	55	nmod	_	_
60	.	.	.	.	_	27	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	factor	factor	NN	NN	_	5	nsubj	_	_
5	appeared	appear	VBD	VBD	_	0	root	_	_
6	when	when	WRB	WRB	_	10	advmod	_	_
7	these	these	DT	DT	_	9	det	_	_
8	CML	cml	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	10	nsubj	_	_
10	achieved	achieve	VBD	VBD	_	5	advcl	_	_
11	complete	complete	JJ	JJ	_	13	amod	_	_
12	haematological	haematological	JJ	JJ	_	13	amod	_	_
13	remission	remission	NN	NN	_	10	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CHR	chr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	through	through	IN	IN	_	19	case	_	_
18	alpha-interferon	alpha-interferon	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	inverse	inverse	JJ	JJ	_	5	amod	_	_
5	relationship	relationship	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	between	between	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	LDL	ldl	NN	NN	_	14	compound	_	_
12	receptor	receptor	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	8	nmod	_	_
15	at	at	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	level	level	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	affinity	affinity	NN	NN	_	14	conj	_	_
23	of	of	IN	IN	_	28	case	_	_
24	this	this	DT	DT	_	28	det	_	_
25	47	47	CD	CD	_	26	compound	_	_
26	kDa	kda	NN	NN	_	28	amod	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	22	nmod	_	_
29	to	to	TO	TO	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	SRE	sre	NN	NN	_	32	compound	_	_
32	sequence	sequence	NN	NN	_	22	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	upon	upon	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	6	advcl	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	propose	propose	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	this	this	DT	DT	_	9	det	_	_
9	factor	factor	NN	NN	_	11	nsubj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	have	have	VB	VB	_	6	ccomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	pathophysiology	pathophysiology	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	chronic	chronic	JJ	JJ	_	19	amod	_	_
18	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
19	leukaemia	leukaemia	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	immunosuppressive	immunosuppressive	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	bovine	bovine	JJ	JJ	_	7	amod	_	_
7	colostrum	colostrum	NN	NN	_	4	nmod	_	_
8	blocks	block	VBZ	VBZ	_	0	root	_	_
9	activation	activation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	interleukin	interleukin	NN	NN	_	15	compound	_	_
13	2	2	CD	CD	_	15	nummod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	enhancer	enhancer	NN	NN	_	9	nmod	_	_
16	at	at	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	NFAT	nfat	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	13	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	bovine	bovine	JJ	JJ	_	5	amod	_	_
5	colostrum	colostrum	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	colostrum	colostrum	NN	NN	_	9	compound	_	_
8	inhibitory	inhibitory	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	2	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	CIF	cif	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	9	punct	_	_
13	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
14	interleukin	interleukin	NN	NN	_	19	compound	_	_
15	2	2	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IL2	il2	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	production	production	NN	NN	_	13	dobj	_	_
20	in	in	IN	IN	_	24	case	_	_
21	activated	activated	JJ	JJ	_	24	amod	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	helper	helper	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	blocking	block	VBG	VBG	_	13	advcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	accumulation	accumulation	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	IL2	il2	NN	NN	_	31	compound	_	_
31	mRNA	mrna	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	5	mark	_	_
4	CIF	cif	NN	NN	_	5	nsubj	_	_
5	blocks	block	VBZ	VBZ	_	2	ccomp	_	_
6	at	at	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	level	level	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IL2	il2	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	introduced	introduce	VBD	VBD	_	2	parataxis	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	plasmids	plasmid	NNS	NNS	_	14	dobj	_	_
17	into	into	IN	IN	_	24	case	_	_
18	the	the	DT	DT	_	24	det	_	_
19	human	human	JJ	JJ	_	24	amod	_	_
20	T	t	NN	NN	_	24	compound	_	_
21	leukemia	leukemia	NN	NN	_	24	compound	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	line	line	NN	NN	_	24	compound	_	_
24	Jurkat	jurkat	NN	NN	_	14	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	transient	transient	JJ	JJ	_	27	amod	_	_
27	transfection	transfection	NN	NN	_	14	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	contained	contain	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	luciferase	luciferase	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	2	dobj	_	_
6	under	under	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	control	control	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	16	case	_	_
10	either	either	CC	CC	_	16	cc:preconj	_	_
11	the	the	DT	DT	_	16	det	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	IL2	il2	NN	NN	_	15	compound	_	_
14	upstream	upstream	JJ	JJ	_	15	amod	_	_
15	enhancer	enhancer	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	8	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	segments	segment	NNS	NNS	_	16	appos	_	_
19	-326	-326	CD	CD	_	21	compound	_	_
20	to	to	TO	TO	_	21	dep	_	_
21	+45	+45	CD	CD	_	18	nummod	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	or	or	CC	CC	_	16	cc	_	_
24	three	three	CD	CD	_	25	nummod	_	_
25	repeats	repeat	NNS	NNS	_	16	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	NFAT	nfat	NN	NN	_	29	compound	_	_
29	element	element	NN	NN	_	25	nmod	_	_
30	contained	contain	VBN	VBN	_	25	acl	_	_
31	within	within	IN	IN	_	32	case	_	_
32	it	it	PRP	PRP	_	30	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	segments	segment	NNS	NNS	_	32	appos	_	_
35	-255	-255	CD	CD	_	37	compound	_	_
36	to	to	TO	TO	_	37	dep	_	_
37	-285	-285	CD	CD	_	34	nummod	_	_
38	)	)	-RRB-	-RRB-	_	34	punct	_	_
39	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	luciferase	luciferase	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	phorbol	phorbol	NN	NN	_	12	compound	_	_
11	myristate	myristate	NN	NN	_	12	compound	_	_
12	acetate	acetate	NN	NN	_	8	nmod	_	_
13	plus	plus	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	calcium	calcium	NN	NN	_	16	compound	_	_
16	ionophore	ionophore	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	8	punct	_	_

1	CIF	cif	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	induction	induction	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	either	either	DT	DT	_	6	det	_	_
6	construct	construct	NN	NN	_	3	nmod	_	_
7	as	as	IN	IN	_	8	dep	_	_
8	did	do	VBD	VBD	_	2	advcl	_	_
9	cyclosporine	cyclosporine	NN	NN	_	8	nsubj	_	_
10	,	,	,	,	_	8	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	known	know	VBN	VBN	_	8	dep	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	block	block	VB	VB	_	13	xcomp	_	_
16	activation	activation	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	NFAT	nfat	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	CIF	cif	NN	NN	_	2	nsubj	_	_
2	failed	fail	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	inhibit	inhibit	VB	VB	_	2	xcomp	_	_
5	several	several	JJ	JJ	_	6	amod	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	enhancer	enhancer	NN	NN	_	8	compound	_	_
8	elements	element	NNS	NNS	_	4	dobj	_	_
9	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	NFAT-controlled	nfat-controlled	JJ	JJ	_	5	amod	_	_
3	luciferase	luciferase	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	system	system	NN	NN	_	6	nsubj	_	_
6	distinguishes	distinguish	VBZ	VBZ	_	0	root	_	_
7	CIF	cif	NN	NN	_	6	dobj	_	_
8	from	from	IN	IN	_	13	case	_	_
9	other	other	JJ	JJ	_	13	amod	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	inhibitory	inhibitory	JJ	JJ	_	13	amod	_	_
13	activities	activity	NNS	NNS	_	6	nmod	_	_
14	present	present	JJ	JJ	_	13	amod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	colostrum	colostrum	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	particular	particular	JJ	JJ	_	6	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	TGF	tgf	NN	NN	_	22	compound	_	_
22	beta	beta	NN	NN	_	6	dobj	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	TGF	tgf	NN	NN	_	26	compound	_	_
26	beta	beta	NN	NN	_	22	conj	_	_
27	2	2	CD	CD	_	26	nummod	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	glucocorticoids	glucocorticoid	NNS	NNS	_	22	conj	_	_
31	.	.	.	.	_	6	punct	_	_

1	Stably	stably	RB	RB	_	2	advmod	_	_
2	transfected	transfect	VBN	VBN	_	4	amod	_	_
3	Jurkat	jurkat	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	behaved	behave	VBD	VBD	_	0	root	_	_
6	similarly	similarly	RB	RB	_	5	advmod	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transiently	transiently	RB	RB	_	10	advmod	_	_
10	transfected	transfect	VBN	VBN	_	11	amod	_	_
11	ones	one	NNS	NNS	_	6	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	respect	respect	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	inhibition	inhibition	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	CIF	cif	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	cyclosporine	cyclosporine	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NFAT-luc	nfat-luc	JJ	JJ	_	3	amod	_	_
3	assay	assay	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	useful	useful	JJ	JJ	_	7	amod	_	_
7	technique	technique	NN	NN	_	0	root	_	_
8	for	for	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	rapid	rapid	JJ	JJ	_	13	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	sensitive	sensitive	JJ	JJ	_	10	dep	_	_
13	measurement	measurement	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	CIF	cif	NN	NN	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	immunosuppressants	immunosuppressant	NNS	NNS	_	15	conj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	similar	similar	JJ	JJ	_	22	amod	_	_
22	mode	mode	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	action	action	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Synergistic	synergistic	JJ	JJ	_	2	amod	_	_
2	interactions	interaction	NNS	NNS	_	15	nsubj	_	_
3	between	between	IN	IN	_	6	case	_	_
4	overlapping	overlap	VBG	VBG	_	6	amod	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	sites	site	NNS	NNS	_	2	nmod	_	_
7	for	for	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	serum	serum	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	ELK-1	elk-1	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	6	conj	_	_
15	mediate	mediate	VBP	VBP	_	0	root	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	basal	basal	JJ	JJ	_	18	amod	_	_
18	enhancement	enhancement	NN	NN	_	15	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	phorbol	phorbol	NN	NN	_	22	compound	_	_
21	ester	ester	NN	NN	_	22	compound	_	_
22	responsiveness	responsiveness	NN	NN	_	18	conj	_	_
23	of	of	IN	IN	_	28	case	_	_
24	primate	primate	JJ	JJ	_	28	amod	_	_
25	cytomegalovirus	cytomegalovirus	NN	NN	_	28	compound	_	_
26	major	major	JJ	JJ	_	28	amod	_	_
27	immediate-early	immediate-early	JJ	JJ	_	28	amod	_	_
28	promoters	promoter	NNS	NNS	_	18	nmod	_	_
29	in	in	IN	IN	_	34	case	_	_
30	monocyte	monocyte	NN	NN	_	34	compound	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	T-lymphocyte	t-lymphocyte	NN	NN	_	30	conj	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	types	type	NNS	NNS	_	15	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	Cytomegalovirus	cytomegalovirus	NN	NN	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CMV	cmv	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	infection	infection	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	nonpermissive	nonpermissive	JJ	JJ	_	0	root	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	persistent	persistent	JJ	JJ	_	7	conj	_	_
10	in	in	IN	IN	_	16	case	_	_
11	many	many	JJ	JJ	_	16	amod	_	_
12	lymphoid	lymphoid	JJ	JJ	_	16	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	myeloid	myeloid	JJ	JJ	_	12	conj	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	types	type	NNS	NNS	_	7	nmod	_	_
17	but	but	CC	CC	_	7	cc	_	_
18	can	can	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	activated	activate	VBN	VBN	_	7	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	differentiated	differentiate	VBN	VBN	_	23	amod	_	_
23	macrophages	macrophage	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	elsewhere	elsewhere	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	23	mark	_	_
6	both	both	CC	CC	_	20	cc:preconj	_	_
7	the	the	DT	DT	_	20	det	_	_
8	major	major	JJ	JJ	_	10	amod	_	_
9	immediate-early	immediate-early	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	20	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MIE	mie	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	lytic	lytic	JJ	JJ	_	19	amod	_	_
16	cycle	cycle	NN	NN	_	19	compound	_	_
17	infectious	infectious	JJ	JJ	_	19	amod	_	_
18	progeny	progeny	NN	NN	_	19	compound	_	_
19	virus	virus	NN	NN	_	10	conj	_	_
20	expression	expression	NN	NN	_	23	nsubjpass	_	_
21	can	can	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	induced	induce	VBN	VBN	_	3	ccomp	_	_
24	in	in	IN	IN	_	30	case	_	_
25	otherwise	otherwise	JJ	JJ	_	26	advmod	_	_
26	nonpermissive	nonpermissive	JJ	JJ	_	30	amod	_	_
27	monocyte-like	monocyte-like	JJ	JJ	_	30	amod	_	_
28	U-937	u-937	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	cultures	culture	NNS	NNS	_	23	nmod	_	_
31	infected	infect	VBN	VBN	_	30	acl	_	_
32	with	with	IN	IN	_	35	case	_	_
33	either	either	CC	CC	_	35	cc:preconj	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	CMV	cmv	NN	NN	_	31	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	HCMV	hcmv	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	or	or	CC	CC	_	35	cc	_	_
40	simian	simian	JJ	JJ	_	41	amod	_	_
41	CMV	cmv	NN	NN	_	35	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	SCMV	scmv	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	by	by	IN	IN	_	46	case	_	_
46	treatment	treatment	NN	NN	_	23	nmod	_	_
47	with	with	IN	IN	_	51	case	_	_
48	the	the	DT	DT	_	51	det	_	_
49	phorbol	phorbol	NN	NN	_	51	compound	_	_
50	ester	ester	NN	NN	_	51	compound	_	_
51	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	46	nmod	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	TPA	tpa	NN	NN	_	51	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	multicopy	multicopy	JJ	JJ	_	5	amod	_	_
3	basal	basal	JJ	JJ	_	5	amod	_	_
4	enhancer	enhancer	NN	NN	_	5	compound	_	_
5	motifs	motif	NNS	NNS	_	62	nsubj	_	_
6	within	within	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	SCMV	scmv	NN	NN	_	10	compound	_	_
9	MIE	mie	NN	NN	_	10	compound	_	_
10	enhancer	enhancer	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	namely	namely	RB	RB	_	5	advmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	11	11	CD	CD	_	15	nummod	_	_
15	copies	copy	NNS	NNS	_	5	appos	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	16-bp	16-bp	JJ	JJ	_	22	amod	_	_
19	cyclic	cyclic	JJ	JJ	_	22	amod	_	_
20	AMP	amp	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	15	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CRE	cre	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	3	3	CD	CD	_	28	nummod	_	_
28	copies	copy	NNS	NNS	_	15	conj	_	_
29	of	of	IN	IN	_	39	case	_	_
30	novel	novel	JJ	JJ	_	39	amod	_	_
31	17-bp	17-bp	JJ	JJ	_	39	amod	_	_
32	serum	serum	NN	NN	_	34	compound	_	_
33	response	response	NN	NN	_	34	compound	_	_
34	factor	factor	NN	NN	_	39	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	SRF	srf	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	binding	binding	NN	NN	_	39	compound	_	_
39	sites	site	NNS	NNS	_	28	nmod	_	_
40	referred	refer	VBN	VBN	_	15	acl	_	_
41	to	to	TO	TO	_	40	nmod	_	_
42	as	as	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	SNE	sne	NN	NN	_	40	nmod	_	_
45	(	(	-LRB-	-LRB-	_	47	punct	_	_
46	SRF/NFkappaB-like	srf/nfkappab-like	JJ	JJ	_	47	amod	_	_
47	element	element	NN	NN	_	44	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	,	,	,	,	_	44	punct	_	_
50	as	as	RB	RB	_	44	cc	_	_
51	well	well	RB	RB	_	50	mwe	_	_
52	as	as	IN	IN	_	50	mwe	_	_
53	four	four	CD	CD	_	56	nummod	_	_
54	classical	classical	JJ	JJ	_	56	amod	_	_
55	NFkappaB	nfkappab	NN	NN	_	56	compound	_	_
56	sites	site	NNS	NNS	_	44	conj	_	_
57	within	within	IN	IN	_	60	case	_	_
58	the	the	DT	DT	_	60	det	_	_
59	HCMV	hcmv	NN	NN	_	60	compound	_	_
60	version	version	NN	NN	_	56	nmod	_	_
61	,	,	,	,	_	44	punct	_	_
62	contribute	contribute	VBP	VBP	_	0	root	_	_
63	to	to	TO	TO	_	65	case	_	_
64	TPA	tpa	NN	NN	_	65	compound	_	_
65	responsiveness	responsiveness	NN	NN	_	62	nmod	_	_
66	in	in	IN	IN	_	68	case	_	_
67	transient	transient	JJ	JJ	_	68	amod	_	_
68	assays	assay	NNS	NNS	_	65	nmod	_	_
69	in	in	IN	IN	_	73	case	_	_
70	monocyte	monocyte	NN	NN	_	73	compound	_	_
71	and	and	CC	CC	_	70	cc	_	_
72	T-cell	t-cell	NN	NN	_	70	conj	_	_
73	types	type	NNS	NNS	_	65	nmod	_	_
74	.	.	.	.	_	62	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	SCMV	scmv	NN	NN	_	4	compound	_	_
3	SNE	sne	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	5	nsubj	_	_
5	contain	contain	VBP	VBP	_	0	root	_	_
6	potential	potential	JJ	JJ	_	11	amod	_	_
7	overlapping	overlap	VBG	VBG	_	11	amod	_	_
8	core	core	NN	NN	_	11	compound	_	_
9	recognition	recognition	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	motifs	motif	NNS	NNS	_	5	dobj	_	_
12	for	for	IN	IN	_	23	case	_	_
13	SRF	srf	NN	NN	_	23	compound	_	_
14	,	,	,	,	_	13	punct	_	_
15	Rel/NFkappaB	rel/nfkappab	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	ETS	ets	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	YY1	yy1	NN	NN	_	13	conj	_	_
21	class	class	NN	NN	_	23	compound	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	11	nmod	_	_
24	but	but	CC	CC	_	5	cc	_	_
25	fail	fail	VBP	VBP	_	5	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	respond	respond	VB	VB	_	25	xcomp	_	_
28	to	to	TO	TO	_	30	case	_	_
29	either	either	CC	CC	_	30	cc:preconj	_	_
30	serum	serum	NN	NN	_	27	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	tumor	tumor	NN	NN	_	35	compound	_	_
33	necrosis	necrosis	NN	NN	_	35	compound	_	_
34	factor	factor	NN	NN	_	35	compound	_	_
35	alpha	alpha	NN	NN	_	30	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	Therefore	therefore	RB	RB	_	37	advmod	_	_
2	,	,	,	,	_	37	punct	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	evaluate	evaluate	VB	VB	_	37	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	TPA	tpa	NN	NN	_	9	compound	_	_
9	responsiveness	responsiveness	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	SNE	sne	NN	NN	_	13	compound	_	_
13	motifs	motif	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	of	of	IN	IN	_	24	case	_	_
16	a	a	DT	DT	_	24	det	_	_
17	related	related	JJ	JJ	_	24	amod	_	_
18	16-bp	16-bp	JJ	JJ	_	24	amod	_	_
19	SEE	see	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	SRF/ETS	srf/ets	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	motif	motif	NN	NN	_	13	conj	_	_
25	found	find	VBN	VBN	_	24	acl	_	_
26	in	in	IN	IN	_	33	case	_	_
27	the	the	DT	DT	_	33	det	_	_
28	HCMV	hcmv	NN	NN	_	33	compound	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	chimpanzee	chimpanzee	NN	NN	_	31	compound	_	_
31	CMV	cmv	NN	NN	_	28	conj	_	_
32	MIE	mie	NN	NN	_	33	compound	_	_
33	enhancers	enhancer	NNS	NNS	_	25	nmod	_	_
34	,	,	,	,	_	37	punct	_	_
35	we	we	PRP	PRP	_	37	nsubj	_	_
36	have	have	VBP	VBP	_	37	aux	_	_
37	examined	examine	VBN	VBN	_	0	root	_	_
38	the	the	DT	DT	_	40	det	_	_
39	functional	functional	JJ	JJ	_	40	amod	_	_
40	responses	response	NNS	NNS	_	37	dobj	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	protein	protein	NN	NN	_	44	compound	_	_
43	binding	binding	NN	NN	_	44	compound	_	_
44	properties	property	NNS	NNS	_	40	conj	_	_
45	of	of	IN	IN	_	50	case	_	_
46	multimerized	multimerized	JJ	JJ	_	50	amod	_	_
47	wild-type	wild-type	JJ	JJ	_	50	amod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	mutant	mutant	JJ	JJ	_	47	conj	_	_
50	elements	element	NNS	NNS	_	40	nmod	_	_
51	added	add	VBN	VBN	_	50	acl	_	_
52	upstream	upstream	RB	RB	_	63	advmod	_	_
53	to	to	TO	TO	_	63	case	_	_
54	the	the	DT	DT	_	63	det	_	_
55	SCMV	scmv	NN	NN	_	56	compound	_	_
56	MIE	mie	NN	NN	_	63	compound	_	_
57	or	or	CC	CC	_	56	cc	_	_
58	simian	simian	JJ	JJ	_	59	amod	_	_
59	virus	virus	NN	NN	_	56	conj	_	_
60	40	40	CD	CD	_	63	nummod	_	_
61	minimal	minimal	JJ	JJ	_	63	amod	_	_
62	promoter	promoter	NN	NN	_	63	compound	_	_
63	regions	region	NNS	NNS	_	51	nmod	_	_
64	in	in	IN	IN	_	77	case	_	_
65	the	the	DT	DT	_	77	det	_	_
66	U-937	u-937	NN	NN	_	77	compound	_	_
67	,	,	,	,	_	66	punct	_	_
68	K-562	k-562	NN	NN	_	66	conj	_	_
69	,	,	,	,	_	66	punct	_	_
70	HL-60	hl-60	NN	NN	_	66	conj	_	_
71	,	,	,	,	_	66	punct	_	_
72	THP-1	thp-1	NN	NN	_	66	conj	_	_
73	,	,	,	,	_	66	punct	_	_
74	and	and	CC	CC	_	66	cc	_	_
75	Jurkat	jurkat	NN	NN	_	66	conj	_	_
76	cell	cell	NN	NN	_	77	compound	_	_
77	lines	line	NNS	NNS	_	63	nmod	_	_
78	.	.	.	.	_	37	punct	_	_

1	Unlike	unlike	IN	IN	_	4	case	_	_
2	classical	classical	JJ	JJ	_	4	amod	_	_
3	NFkappaB	nfkappab	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	neither	neither	CC	CC	_	8	cc:preconj	_	_
7	the	the	DT	DT	_	8	det	_	_
8	SNE	sne	NN	NN	_	12	compound	_	_
9	nor	nor	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	SEE	see	NN	NN	_	8	conj	_	_
12	motif	motif	NN	NN	_	13	nsubj	_	_
13	responded	respond	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	phosphatase	phosphatase	NN	NN	_	16	compound	_	_
16	inhibition	inhibition	NN	NN	_	13	nmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	okadaic	okadaic	JJ	JJ	_	19	amod	_	_
19	acid	acid	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TPA	tpa	NN	NN	_	5	compound	_	_
5	responsiveness	responsiveness	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	both	both	DT	DT	_	9	det	_	_
8	CMV	cmv	NN	NN	_	9	compound	_	_
9	elements	element	NNS	NNS	_	5	nmod	_	_
10	proved	prove	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	involve	involve	VB	VB	_	10	xcomp	_	_
13	synergistic	synergistic	JJ	JJ	_	14	amod	_	_
14	interactions	interaction	NNS	NNS	_	12	dobj	_	_
15	between	between	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	core	core	NN	NN	_	20	compound	_	_
18	SRF	srf	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	14	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	CCATATATGG	ccatatatgg	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	the	the	DT	DT	_	30	det	_	_
26	adjacent	adjacent	JJ	JJ	_	30	amod	_	_
27	inverted	invert	VBN	VBN	_	30	amod	_	_
28	ETS	ets	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	motifs	motif	NNS	NNS	_	20	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	TTCC	ttcc	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	,	,	,	,	_	14	punct	_	_
35	which	which	WDT	WDT	_	36	nsubj	_	_
36	correlated	correlate	VBD	VBD	_	14	acl:relcl	_	_
37	directly	directly	RB	RB	_	36	advmod	_	_
38	with	with	IN	IN	_	39	case	_	_
39	formation	formation	NN	NN	_	36	nmod	_	_
40	of	of	IN	IN	_	44	case	_	_
41	a	a	DT	DT	_	44	det	_	_
42	bound	bind	VBN	VBN	_	44	amod	_	_
43	tripartite	tripartite	JJ	JJ	_	44	amod	_	_
44	complex	complex	NN	NN	_	39	nmod	_	_
45	containing	contain	VBG	VBG	_	44	acl	_	_
46	both	both	CC	CC	_	49	cc:preconj	_	_
47	the	the	DT	DT	_	49	det	_	_
48	cellular	cellular	JJ	JJ	_	49	amod	_	_
49	SRF	srf	NN	NN	_	45	dobj	_	_
50	and	and	CC	CC	_	49	cc	_	_
51	ELK-1	elk-1	NN	NN	_	52	compound	_	_
52	proteins	protein	NNS	NNS	_	49	conj	_	_
53	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	complex	complex	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	abundant	abundant	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	15	case	_	_
8	U-937	u-937	NN	NN	_	15	compound	_	_
9	,	,	,	,	_	8	punct	_	_
10	K-562	k-562	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	HeLa	hela	NN	NN	_	8	conj	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	extracts	extract	NNS	NNS	_	6	nmod	_	_
16	than	than	IN	IN	_	27	case	_	_
17	in	in	IN	IN	_	27	case	_	_
18	Raji	raji	NN	NN	_	27	compound	_	_
19	,	,	,	,	_	18	punct	_	_
20	HF	hf	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	BALB/c	balb/c	NN	NN	_	23	compound	_	_
23	3T3	3t3	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	18	punct	_	_
25	or	or	CC	CC	_	18	cc	_	_
26	HL-60	hl-60	NN	NN	_	18	conj	_	_
27	cells	cell	NNS	NNS	_	6	advcl	_	_
28	,	,	,	,	_	6	punct	_	_
29	but	but	CC	CC	_	6	cc	_	_
30	the	the	DT	DT	_	32	det	_	_
31	binding	binding	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	34	nsubjpass	_	_
33	was	be	VBD	VBD	_	34	auxpass	_	_
34	altered	alter	VBN	VBN	_	6	conj	_	_
35	only	only	RB	RB	_	36	advmod	_	_
36	twofold	twofold	RB	RB	_	34	advmod	_	_
37	after	after	IN	IN	_	39	case	_	_
38	TPA	tpa	NN	NN	_	39	compound	_	_
39	treatment	treatment	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	40-fold	40-fold	JJ	JJ	_	3	amod	_	_
3	stimulation	stimulation	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	chloramphenicol	chloramphenicol	JJ	JJ	_	7	amod	_	_
6	acetyltransferase	acetyltransferase	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	nmod	_	_
8	mediated	mediate	VBN	VBN	_	3	acl	_	_
9	by	by	IN	IN	_	12	case	_	_
10	four	four	CD	CD	_	12	nummod	_	_
11	tandem	tandem	JJ	JJ	_	12	amod	_	_
12	repeats	repeat	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	SNE	sne	NN	NN	_	12	nmod	_	_
16	could	could	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	aux	_	_
18	induced	induce	VBN	VBN	_	0	root	_	_
19	within	within	IN	IN	_	21	case	_	_
20	2	2	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	18	punct	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	up	up	RB	RB	_	26	advmod	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	250-fold	250-fold	JJ	JJ	_	18	conj	_	_
27	within	within	IN	IN	_	29	case	_	_
28	6	6	CD	CD	_	29	nummod	_	_
29	h	h	NN	NN	_	26	nmod	_	_
30	)	)	-RRB-	-RRB-	_	18	punct	_	_
31	after	after	IN	IN	_	32	case	_	_
32	addition	addition	NN	NN	_	18	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	TPA	tpa	NN	NN	_	32	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	DNA-transfected	dna-transfected	JJ	JJ	_	38	amod	_	_
37	U-937	u-937	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	32	nmod	_	_
39	,	,	,	,	_	18	punct	_	_
40	indicating	indicate	VBG	VBG	_	18	xcomp	_	_
41	that	that	IN	IN	_	44	mark	_	_
42	the	the	DT	DT	_	43	det	_	_
43	stimulation	stimulation	NN	NN	_	44	nsubj	_	_
44	appeared	appear	VBD	VBD	_	40	ccomp	_	_
45	likely	likely	JJ	JJ	_	44	xcomp	_	_
46	to	to	TO	TO	_	55	mark	_	_
47	be	be	VB	VB	_	55	cop	_	_
48	a	a	DT	DT	_	55	det	_	_
49	true	true	JJ	JJ	_	55	amod	_	_
50	protein	protein	NN	NN	_	52	nmod:npmod	_	_
51	kinase	kinase	NN	NN	_	52	nmod:npmod	_	_
52	C-mediated	c-mediated	JJ	JJ	_	55	amod	_	_
53	signal	signal	NN	NN	_	55	compound	_	_
54	transduction	transduction	NN	NN	_	55	compound	_	_
55	event	event	NN	NN	_	45	xcomp	_	_
56	rather	rather	RB	RB	_	55	cc	_	_
57	than	than	IN	IN	_	56	mwe	_	_
58	a	a	DT	DT	_	60	det	_	_
59	differentiation	differentiation	NN	NN	_	60	compound	_	_
60	response	response	NN	NN	_	55	conj	_	_
61	.	.	.	.	_	18	punct	_	_

1	Slight	slight	JJ	JJ	_	2	amod	_	_
2	differences	difference	NNS	NNS	_	37	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	sequence	sequence	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	core	core	NN	NN	_	11	compound	_	_
9	SRF	srf	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	5	nmod	_	_
12	compared	compare	VBN	VBN	_	14	case	_	_
13	with	with	IN	IN	_	14	case	_	_
14	that	that	DT	DT	_	2	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	classical	classical	JJ	JJ	_	22	amod	_	_
18	c-Fos	c-fos	NN	NN	_	22	compound	_	_
19	promoter	promoter	NN	NN	_	22	compound	_	_
20	serum	serum	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	14	nmod	_	_
23	,	,	,	,	_	2	punct	_	_
24	together	together	RB	RB	_	26	advmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	differences	difference	NNS	NNS	_	2	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	spacing	spacing	NN	NN	_	26	nmod	_	_
30	between	between	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	SRF	srf	NN	NN	_	35	compound	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	ETS	ets	NN	NN	_	32	conj	_	_
35	motifs	motif	NNS	NNS	_	26	nmod	_	_
36	,	,	,	,	_	2	punct	_	_
37	appear	appear	VBP	VBP	_	0	root	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	account	account	VB	VB	_	37	xcomp	_	_
40	for	for	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	inability	inability	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	SCMV	scmv	NN	NN	_	46	compound	_	_
46	SNEs	sne	NNS	NNS	_	42	nmod	_	_
47	to	to	TO	TO	_	48	mark	_	_
48	respond	respond	VB	VB	_	42	acl	_	_
49	to	to	TO	TO	_	51	case	_	_
50	serum	serum	NN	NN	_	51	compound	_	_
51	induction	induction	NN	NN	_	48	nmod	_	_
52	.	.	.	.	_	37	punct	_	_

1	Energy	energy	NN	NN	_	2	compound	_	_
2	substrates	substrate	NNS	NNS	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	hormone	hormone	NN	NN	_	5	compound	_	_
5	responses	response	NNS	NNS	_	2	conj	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	2	conj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
11	during	during	IN	IN	_	14	case	_	_
12	intense	intense	JJ	JJ	_	14	amod	_	_
13	physical	physical	JJ	JJ	_	12	dep	_	_
14	exercise	exercise	NN	NN	_	2	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	humans	human	NNS	NNS	_	2	nmod	_	_
17	following	follow	VBG	VBG	_	19	case	_	_
18	phosphocreatine	phosphocreatine	JJ	JJ	_	19	amod	_	_
19	administration	administration	NN	NN	_	2	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Eight	eight	CD	CD	_	5	nummod	_	_
2	healthy	healthy	JJ	JJ	_	4	amod	_	_
3	untrained	untrained	JJ	JJ	_	4	amod	_	_
4	male	male	JJ	JJ	_	5	amod	_	_
5	volunteers	volunteer	NNS	NNS	_	6	nsubj	_	_
6	pedalled	pedal	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	cycle	cycle	NN	NN	_	9	compound	_	_
9	ergometer	ergometer	NN	NN	_	6	dobj	_	_
10	according	accord	VBG	VBG	_	14	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	exercise	exercise	NN	NN	_	14	compound	_	_
14	protocols	protocol	NNS	NNS	_	6	nmod	_	_
15	:	:	:	:	_	6	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	first	first	JJ	JJ	_	18	nsubj	_	_
18	involved	involve	VBD	VBD	_	6	parataxis	_	_
19	step-wise	step-wise	RB	RB	_	20	advmod	_	_
20	increasing	increase	VBG	VBG	_	22	amod	_	_
21	physical	physical	JJ	JJ	_	22	amod	_	_
22	exercise	exercise	NN	NN	_	18	dobj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	maximal	maximal	JJ	JJ	_	22	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	MPE	mpe	NN	NN	_	22	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	;	;	:	:	_	18	punct	_	_
29	the	the	DT	DT	_	30	det	_	_
30	second	second	JJ	JJ	_	31	nsubj	_	_
31	involved	involve	VBD	VBD	_	18	parataxis	_	_
32	prolonged	prolonged	JJ	JJ	_	39	amod	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	35	35	CD	CD	_	35	nummod	_	_
35	min	min	NN	NN	_	32	dep	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	submaximal	submaximal	JJ	JJ	_	32	dep	_	_
38	physical	physical	JJ	JJ	_	39	amod	_	_
39	exercise	exercise	NN	NN	_	31	dobj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	PPE	ppe	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	at	at	IN	IN	_	45	case	_	_
44	70	70	CD	CD	_	45	nummod	_	_
45	%	%	NN	NN	_	39	nmod	_	_
46	of	of	IN	IN	_	52	case	_	_
47	the	the	DT	DT	_	52	det	_	_
48	individual	individual	NN	NN	_	52	nmod:poss	_	_
49	's	's	POS	POS	_	52	case	_	_
50	maximal	maximal	JJ	JJ	_	52	amod	_	_
51	oxygen	oxygen	NN	NN	_	52	compound	_	_
52	uptake	uptake	NN	NN	_	45	nmod	_	_
53	.	.	.	.	_	6	punct	_	_

1	Each	each	DT	DT	_	2	det	_	_
2	volunteer	volunteer	NN	NN	_	3	nsubj	_	_
3	performed	perform	VBD	VBD	_	0	root	_	_
4	these	these	DT	DT	_	5	det	_	_
5	exercise	exercise	NN	NN	_	3	dobj	_	_
6	twice	twice	RB	RB	_	3	advmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	following	follow	VBG	VBG	_	3	advcl	_	_
9	either	either	CC	CC	_	12	dep	_	_
10	an	a	DT	DT	_	12	det	_	_
11	intravenous	intravenous	JJ	JJ	_	12	amod	_	_
12	injection	injection	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	phosphocreatine	phosphocreatine	JJ	JJ	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PCr	pcr	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	or	or	CC	CC	_	14	cc	_	_
19	a	a	DT	DT	_	20	det	_	_
20	placebo	placebo	NN	NN	_	14	conj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	an	a	DT	DT	_	25	det	_	_
23	isotonic	isotonic	JJ	JJ	_	25	amod	_	_
24	NaCl	nacl	NN	NN	_	25	compound	_	_
25	solution	solution	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Anaerobic	anaerobic	JJ	JJ	_	2	amod	_	_
2	threshold	threshold	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	AT	at	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	determined	determine	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	point	point	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	departure	departure	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	ventilatory	ventilatory	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	12	nmod	_	_
17	from	from	IN	IN	_	18	case	_	_
18	linearity	linearity	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	from	from	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	sudden	sudden	JJ	JJ	_	23	amod	_	_
23	increase	increase	NN	NN	_	10	conj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	venous	venous	JJ	JJ	_	28	amod	_	_
26	blood	blood	NN	NN	_	28	compound	_	_
27	lactate	lactate	NN	NN	_	28	compound	_	_
28	concentrations	concentration	NNS	NNS	_	23	nmod	_	_
29	during	during	IN	IN	_	30	case	_	_
30	MPE	mpe	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	exercise	exercise	NN	NN	_	7	nmod	_	_
3	following	follow	VBG	VBG	_	5	case	_	_
4	placebo	placebo	NN	NN	_	5	compound	_	_
5	administration	administration	NN	NN	_	2	nmod	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	observed	observe	VBD	VBD	_	0	root	_	_
8	increases	increase	NNS	NNS	_	7	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	substrates	substrate	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	plasma	plasma	NN	NN	_	16	compound	_	_
16	adrenocorticotropin	adrenocorticotropin	NN	NN	_	13	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ACTH	acth	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	13	punct	_	_
21	growth	growth	NN	NN	_	22	compound	_	_
22	hormone	hormone	NN	NN	_	13	conj	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	cortisol	cortisol	NN	NN	_	13	conj	_	_
25	and	and	CC	CC	_	10	cc	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	number	number	NN	NN	_	10	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	glucocorticoid	glucocorticoid	NN	NN	_	31	compound	_	_
31	receptors	receptor	NNS	NNS	_	28	nmod	_	_
32	in	in	IN	IN	_	33	case	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
34	without	without	IN	IN	_	35	case	_	_
35	changes	change	NNS	NNS	_	7	nmod	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	dissociation	dissociation	NN	NN	_	39	compound	_	_
39	constant	constant	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	7	punct	_	_

1	Intravenous	intravenous	JJ	JJ	_	2	amod	_	_
2	administration	administration	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PCr	pcr	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	starting	start	VBG	VBG	_	2	dep	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	day	day	NN	NN	_	6	nmod	_	_
9	before	before	IN	IN	_	8	case	_	_
10	exercise	exercise	NN	NN	_	8	dep	_	_
11	)	)	-RRB-	-RRB-	_	6	punct	_	_
12	led	lead	VBD	VBD	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	increase	increase	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	total	total	JJ	JJ	_	19	amod	_	_
19	workload	workload	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	on	on	IN	IN	_	22	case	_	_
22	average	average	NN	NN	_	19	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	5.8	5.8	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	22	nmod	_	_
26	)	)	-RRB-	-RRB-	_	22	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	in	in	IN	IN	_	29	case	_	_
29	AT	at	NN	NN	_	19	conj	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	on	on	IN	IN	_	32	case	_	_
32	average	average	NN	NN	_	29	nmod	_	_
33	by	by	IN	IN	_	35	case	_	_
34	6.8	6.8	CD	CD	_	35	nummod	_	_
35	%	%	NN	NN	_	32	nmod	_	_
36	)	)	-RRB-	-RRB-	_	32	punct	_	_
37	during	during	IN	IN	_	38	case	_	_
38	MPE	mpe	NN	NN	_	15	nmod	_	_
39	and	and	CC	CC	_	15	cc	_	_
40	to	to	TO	TO	_	43	case	_	_
41	a	a	DT	DT	_	43	det	_	_
42	better	better	JJR	JJR	_	43	amod	_	_
43	tolerance	tolerance	NN	NN	_	15	conj	_	_
44	of	of	IN	IN	_	45	case	_	_
45	exercise	exercise	NN	NN	_	43	nmod	_	_
46	during	during	IN	IN	_	47	case	_	_
47	PPE	ppe	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	12	punct	_	_

1	Following	follow	VBG	VBG	_	3	case	_	_
2	PCr	pcr	NN	NN	_	3	compound	_	_
3	administration	administration	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	observed	observe	VBD	VBD	_	0	root	_	_
6	lower	lower	JJR	JJR	_	9	amod	_	_
7	blood	blood	NN	NN	_	9	compound	_	_
8	lactate	lactate	NN	NN	_	9	compound	_	_
9	concentrations	concentration	NNS	NNS	_	5	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	patterns	pattern	NNS	NNS	_	9	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	some	some	DT	DT	_	16	det	_	_
15	enzyme	enzyme	NN	NN	_	16	compound	_	_
16	activities	activity	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	less	less	RBR	RBR	_	19	advmod	_	_
19	pronounced	pronounced	JJ	JJ	_	20	amod	_	_
20	changes	change	NNS	NNS	_	9	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	plasma	plasma	NN	NN	_	23	compound	_	_
23	ACTH	acth	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	cortisol	cortisol	NN	NN	_	23	conj	_	_
26	concentrations	concentration	NNS	NNS	_	23	dep	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	in	in	IN	IN	_	30	case	_	_
29	glucocorticoid	glucocorticoid	NN	NN	_	30	compound	_	_
30	binding	binding	NN	NN	_	23	conj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	30	nmod	_	_
33	,	,	,	,	_	9	punct	_	_
34	but	but	CC	CC	_	9	cc	_	_
35	no	no	DT	DT	_	36	neg	_	_
36	changes	change	NNS	NNS	_	9	conj	_	_
37	in	in	IN	IN	_	41	case	_	_
38	plasma	plasma	NN	NN	_	41	compound	_	_
39	growth	growth	NN	NN	_	41	compound	_	_
40	hormone	hormone	NN	NN	_	41	compound	_	_
41	concentrations	concentration	NNS	NNS	_	36	nmod	_	_
42	compared	compare	VBN	VBN	_	45	case	_	_
43	to	to	TO	TO	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	placebo	placebo	NN	NN	_	36	acl	_	_
46	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	intense	intense	JJ	JJ	_	7	amod	_	_
6	physical	physical	JJ	JJ	_	5	dep	_	_
7	exercise	exercise	NN	NN	_	8	nsubj	_	_
8	led	lead	VBD	VBD	_	3	ccomp	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	only	only	RB	RB	_	12	cc:preconj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	increases	increase	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	hormone	hormone	NN	NN	_	16	compound	_	_
16	concentrations	concentration	NNS	NNS	_	12	nmod	_	_
17	but	but	CC	CC	_	12	cc	_	_
18	also	also	RB	RB	_	21	advmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	12	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	density	density	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	glucocorticoid	glucocorticoid	NN	NN	_	27	compound	_	_
27	receptors	receptor	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Intravenous	intravenous	JJ	JJ	_	3	amod	_	_
2	PCr	pcr	NN	NN	_	3	compound	_	_
3	injection	injection	NN	NN	_	4	nsubj	_	_
4	led	lead	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	smaller	smaller	JJR	JJR	_	7	amod	_	_
7	changes	change	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	ACTH	acth	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	cortisol	cortisol	NN	NN	_	9	conj	_	_
12	concentrations	concentration	NNS	NNS	_	9	dep	_	_
13	as	as	RB	RB	_	7	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	to	to	TO	TO	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	lower	lower	JJR	JJR	_	19	amod	_	_
19	activation	activation	NN	NN	_	7	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Acetylsalicylic	acetylsalicylic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	sodium	sodium	NN	NN	_	5	compound	_	_
5	salicylate	salicylate	NN	NN	_	2	conj	_	_
6	inhibit	inhibit	VBP	VBP	_	0	root	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	11	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
9	B/c-Rel	b/c-rel	NN	NN	_	11	compound	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	6	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	synthesis	synthesis	NN	NN	_	11	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	tissue	tissue	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TF	tf	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	tumor	tumor	NN	NN	_	25	compound	_	_
23	necrosis	necrosis	NN	NN	_	25	compound	_	_
24	factor	factor	NN	NN	_	25	compound	_	_
25	alfa	alfa	NN	NN	_	17	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	TNF-alpha	tnf-alpha	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	in	in	IN	IN	_	31	case	_	_
30	human	human	JJ	JJ	_	31	amod	_	_
31	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	acetylsalicylic	acetylsalicylic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	salicylate	salicylate	NN	NN	_	8	conj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	LPS-induced	lps-induced	JJ	JJ	_	15	amod	_	_
15	synthesis	synthesis	NN	NN	_	5	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	pro-coagulant	pro-coagulant	JJ	JJ	_	19	amod	_	_
19	protein	protein	NN	NN	_	15	nmod	_	_
20	tissue	tissue	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	19	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	TF	tf	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	pro-inflammatory	pro-inflammatory	JJ	JJ	_	28	amod	_	_
28	protein	protein	NN	NN	_	19	conj	_	_
29	tumor	tumor	NN	NN	_	31	compound	_	_
30	necrosis	necrosis	NN	NN	_	31	compound	_	_
31	factor-alpha	factor-alpha	NN	NN	_	28	dep	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	TNF-alpha	tnf-alpha	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	15	punct	_	_
36	as	as	RB	RB	_	15	cc	_	_
37	well	well	RB	RB	_	36	mwe	_	_
38	as	as	IN	IN	_	36	mwe	_	_
39	the	the	DT	DT	_	41	det	_	_
40	prostaglandin	prostaglandin	NN	NN	_	41	compound	_	_
41	PGE2	pge2	NN	NN	_	15	conj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	human	human	JJ	JJ	_	44	amod	_	_
44	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	drugs	drug	NNS	NNS	_	4	nsubj	_	_
3	dose-dependently	dose-dependently	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	LPS-induced	lps-induced	JJ	JJ	_	9	amod	_	_
6	TF	tf	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	6	conj	_	_
9	synthesis	synthesis	NN	NN	_	4	dobj	_	_
10	at	at	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	protein	protein	NN	NN	_	12	conj	_	_
16	level	level	NN	NN	_	12	dep	_	_
17	,	,	,	,	_	4	punct	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	reduced	reduce	VBD	VBD	_	4	conj	_	_
20	PGE2	pge2	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	evidenced	evidence	VBN	VBN	_	24	advcl	_	_
3	by	by	IN	IN	_	7	case	_	_
4	electro	electro	NN	NN	_	7	compound	_	_
5	mobility	mobility	NN	NN	_	7	compound	_	_
6	shift	shift	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EMSA	emsa	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	use	use	NN	NN	_	7	conj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	prototypic	prototypic	JJ	JJ	_	19	amod	_	_
19	probe	probe	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	24	punct	_	_
21	these	these	DT	DT	_	22	det	_	_
22	drugs	drug	NNS	NNS	_	24	nsubj	_	_
23	probably	probably	RB	RB	_	24	advmod	_	_
24	exert	exert	VBP	VBP	_	0	root	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	inhibitory	inhibitory	JJ	JJ	_	27	amod	_	_
27	effects	effect	NNS	NNS	_	24	dobj	_	_
28	by	by	IN	IN	_	29	case	_	_
29	interference	interference	NN	NN	_	24	nmod	_	_
30	with	with	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
33	translocation	translocation	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
36	B/c-Rel	b/c-rel	NN	NN	_	37	compound	_	_
37	proteins	protein	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	24	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	expand	expand	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	understanding	understanding	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	anti-thrombotic	anti-thrombotic	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	anti-inflammatory	anti-inflammatory	JJ	JJ	_	9	conj	_	_
12	effects	effect	NNS	NNS	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	drugs	drug	NNS	NNS	_	12	nmod	_	_
16	when	when	WRB	WRB	_	20	advmod	_	_
17	activation	activation	NN	NN	_	20	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
20	occurs	occur	VBZ	VBZ	_	12	acl:relcl	_	_
21	.	.	.	.	_	4	punct	_	_

1	Octamer	octamer	NN	NN	_	2	nmod:npmod	_	_
2	independent	independent	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	transcription	transcription	NN	NN	_	3	nmod	_	_
6	from	from	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	immunoglobulin	immunoglobulin	NN	NN	_	11	compound	_	_
10	germline	germline	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	analyses	analysis	NNS	NNS	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	7	compound	_	_
5	V	v	JJ	JJ	_	7	amod	_	_
6	region	region	NN	NN	_	7	compound	_	_
7	promoters	promoter	NNS	NNS	_	2	nmod	_	_
8	has	have	VBZ	VBZ	_	9	aux	_	_
9	led	lead	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	discovery	discovery	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	common	common	JJ	JJ	_	17	amod	_	_
16	octamer	octamer	NN	NN	_	17	compound	_	_
17	motif	motif	NN	NN	_	12	nmod	_	_
18	which	which	WDT	WDT	_	21	nsubj	_	_
19	is	be	VBZ	VBZ	_	21	cop	_	_
20	functionally	functionally	RB	RB	_	21	advmod	_	_
21	important	important	JJ	JJ	_	17	acl:relcl	_	_
22	in	in	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	tissue-specific	tissue-specific	JJ	JJ	_	29	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	developmentally	developmentally	RB	RB	_	27	advmod	_	_
27	regulated	regulate	VBN	VBN	_	24	conj	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activation	activation	NN	NN	_	21	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	immunoglobulin	immunoglobulin	NN	NN	_	32	compound	_	_
32	genes	gene	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	germline	germline	NN	NN	_	3	compound	_	_
3	promoters	promoter	NNS	NNS	_	20	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	Ko	ko	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	located	located	JJ	JJ	_	3	amod	_	_
8	upstream	upstream	RB	RB	_	7	advmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	J	j	JJ	JJ	_	14	amod	_	_
12	region	region	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	segments	segment	NNS	NNS	_	8	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	locus	locus	NN	NN	_	14	nmod	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	contain	contain	VBP	VBP	_	0	root	_	_
21	an	a	DT	DT	_	23	det	_	_
22	octamer	octamer	NN	NN	_	23	compound	_	_
23	motif	motif	NN	NN	_	20	dobj	_	_
24	(	(	-LRB-	-LRB-	_	23	punct	_	_
25	containing	contain	VBG	VBG	_	23	dep	_	_
26	a	a	DT	DT	_	30	det	_	_
27	single	single	JJ	JJ	_	30	amod	_	_
28	base	base	NN	NN	_	30	compound	_	_
29	pair	pair	NN	NN	_	30	compound	_	_
30	mutation	mutation	NN	NN	_	25	dobj	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	referred	refer	VBN	VBN	_	25	conj	_	_
33	to	to	TO	TO	_	32	nmod	_	_
34	as	as	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	variant	variant	JJ	JJ	_	37	amod	_	_
37	octamer	octamer	NN	NN	_	32	nmod	_	_
38	)	)	-RRB-	-RRB-	_	23	punct	_	_
39	which	which	WDT	WDT	_	42	nsubjpass	_	_
40	has	have	VBZ	VBZ	_	42	aux	_	_
41	been	be	VBN	VBN	_	42	auxpass	_	_
42	shown	show	VBN	VBN	_	23	acl:relcl	_	_
43	previously	previously	RB	RB	_	42	advmod	_	_
44	to	to	TO	TO	_	45	mark	_	_
45	bind	bind	VB	VB	_	42	xcomp	_	_
46	Oct-1	oct-1	NN	NN	_	50	compound	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	Oct-2	oct-2	NN	NN	_	46	conj	_	_
49	transcription	transcription	NN	NN	_	50	compound	_	_
50	factors	factor	NNS	NNS	_	45	dobj	_	_
51	in	in	FW	FW	_	52	compound	_	_
52	vitro	vitro	FW	FW	_	45	advmod	_	_
53	.	.	.	.	_	20	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	elucidate	elucidate	VB	VB	_	25	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	this	this	DT	DT	_	10	det	_	_
8	variant	variant	JJ	JJ	_	10	amod	_	_
9	octamer	octamer	NN	NN	_	10	compound	_	_
10	motif	motif	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	germline	germline	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	from	from	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	unrearranged	unrearranged	JJ	JJ	_	21	amod	_	_
20	kappa	kappa	NN	NN	_	21	compound	_	_
21	locus	locus	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	we	we	PRP	PRP	_	25	nsubj	_	_
24	have	have	VBP	VBP	_	25	aux	_	_
25	quantitated	quantitate	VBN	VBN	_	0	root	_	_
26	the	the	DT	DT	_	29	det	_	_
27	relative	relative	JJ	JJ	_	29	amod	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	affinity	affinity	NN	NN	_	25	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	Oct-1	oct-1	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	Oct-2	oct-2	NN	NN	_	31	conj	_	_
34	for	for	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	variant	variant	JJ	JJ	_	38	amod	_	_
37	octamer	octamer	NN	NN	_	38	compound	_	_
38	motif	motif	NN	NN	_	29	nmod	_	_
39	and	and	CC	CC	_	25	cc	_	_
40	determined	determine	VBD	VBD	_	25	conj	_	_
41	the	the	DT	DT	_	43	det	_	_
42	functional	functional	JJ	JJ	_	43	amod	_	_
43	role	role	NN	NN	_	40	dobj	_	_
44	of	of	IN	IN	_	47	case	_	_
45	this	this	DT	DT	_	47	det	_	_
46	octamer	octamer	NN	NN	_	47	compound	_	_
47	motif	motif	NN	NN	_	43	nmod	_	_
48	in	in	IN	IN	_	50	case	_	_
49	transcriptional	transcriptional	JJ	JJ	_	50	amod	_	_
50	activation	activation	NN	NN	_	43	nmod	_	_
51	.	.	.	.	_	25	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	40	mark	_	_
4	,	,	,	,	_	40	punct	_	_
5	although	although	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	variant	variant	JJ	JJ	_	9	amod	_	_
8	octamer	octamer	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	10	nsubj	_	_
10	binds	bind	VBZ	VBZ	_	40	advcl	_	_
11	Oct-1	oct-1	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Oct-2	oct-2	NN	NN	_	11	conj	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	10	advmod	_	_
16	with	with	IN	IN	_	19	case	_	_
17	5-fold	5-fold	JJ	JJ	_	19	amod	_	_
18	lower	lower	JJR	JJR	_	17	dep	_	_
19	affinity	affinity	NN	NN	_	10	nmod	_	_
20	than	than	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	consensus	consensus	NN	NN	_	24	compound	_	_
23	octamer	octamer	NN	NN	_	24	compound	_	_
24	motif	motif	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	40	punct	_	_
26	mutation	mutation	NN	NN	_	40	nsubj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	variant	variant	JJ	JJ	_	31	amod	_	_
30	octamer	octamer	NN	NN	_	31	compound	_	_
31	motif	motif	NN	NN	_	26	nmod	_	_
32	to	to	TO	TO	_	39	case	_	_
33	either	either	CC	CC	_	39	cc:preconj	_	_
34	a	a	DT	DT	_	39	det	_	_
35	consensus	consensus	NN	NN	_	36	compound	_	_
36	octamer	octamer	NN	NN	_	39	compound	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	non-octamer	non-octamer	JJ	JJ	_	36	conj	_	_
39	motif	motif	NN	NN	_	26	nmod	_	_
40	has	have	VBZ	VBZ	_	2	ccomp	_	_
41	no	no	DT	DT	_	42	neg	_	_
42	effect	effect	NN	NN	_	40	dobj	_	_
43	on	on	IN	IN	_	45	case	_	_
44	transcriptional	transcriptional	JJ	JJ	_	45	amod	_	_
45	activation	activation	NN	NN	_	40	nmod	_	_
46	from	from	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	germline	germline	NN	NN	_	49	compound	_	_
49	promoter	promoter	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	find	find	VBP	VBP	_	0	root	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	differences	difference	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	activation	activation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	germline	germline	NN	NN	_	13	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	V	v	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	9	conj	_	_
13	promoters	promoter	NNS	NNS	_	7	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	kappa	kappa	NN	NN	_	16	compound	_	_
16	enhancers	enhancer	NNS	NNS	_	7	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	germline	germline	NN	NN	_	7	compound	_	_
7	promoters	promoter	NNS	NNS	_	12	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	V	v	JJ	JJ	_	11	amod	_	_
10	region	region	NN	NN	_	11	compound	_	_
11	promoters	promoter	NNS	NNS	_	7	conj	_	_
12	differ	differ	VBP	VBP	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	dependence	dependence	NN	NN	_	12	nmod	_	_
16	on	on	IN	IN	_	17	case	_	_
17	octamer	octamer	NN	NN	_	15	nmod	_	_
18	for	for	IN	IN	_	19	case	_	_
19	activation	activation	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	respond	respond	VBP	VBP	_	12	conj	_	_
22	differently	differently	RB	RB	_	21	advmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	enhancer	enhancer	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	have	have	VBP	VBP	_	0	root	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	implications	implication	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	regulation	regulation	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	germline	germline	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	7	nmod	_	_
11	as	as	RB	RB	_	7	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	concomitant	concomitant	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	7	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	V-J	v-j	JJ	JJ	_	19	amod	_	_
19	recombination	recombination	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	kappa	kappa	NN	NN	_	25	compound	_	_
23	light	light	JJ	JJ	_	25	amod	_	_
24	chain	chain	NN	NN	_	25	compound	_	_
25	locus	locus	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	murine	murine	JJ	JJ	_	9	amod	_	_
5	cyclin-dependent	cyclin-dependent	JJ	JJ	_	9	amod	_	_
6	kinase	kinase	NN	NN	_	9	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	p27Kip1	p27kip1	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	cyclin-dependent	cyclin-dependent	JJ	JJ	_	5	amod	_	_
3	kinase	kinase	NN	NN	_	5	compound	_	_
4	inhibitor	inhibitor	NN	NN	_	5	compound	_	_
5	p27Kip1	p27kip1	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	regulating	regulate	VBG	VBG	_	6	advcl	_	_
12	cell-cycle	cell-cycle	JJ	JJ	_	13	amod	_	_
13	progression	progression	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	6	punct	_	_

1	p27Kip1	p27kip1	NN	NN	_	3	nsubj	_	_
2	directly	directly	RB	RB	_	3	advmod	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	catalytic	catalytic	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	cyclin/cdks	cyclin/cdks	NNS	NNS	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	cyclin-dependent	cyclin-dependent	JJ	JJ	_	11	amod	_	_
11	kinase	kinase	NN	NN	_	13	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	complexes	complex	NNS	NNS	_	6	nmod	_	_
14	and/or	and/or	CC	CC	_	3	cc	_	_
15	interferes	interfere	VBZ	VBZ	_	3	conj	_	_
16	physically	physically	RB	RB	_	15	advmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	cyclin/cdks	cyclin/cdks	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	15	nmod	_	_
20	by	by	IN	IN	_	21	case	_	_
21	CAK	cak	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	expression	expression	NN	NN	_	5	compound	_	_
5	level	level	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	p27Kip1	p27kip1	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	maximal	maximal	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	resting	rest	VBG	VBG	_	14	amod	_	_
13	Go	go	NN	NN	_	14	compound	_	_
14	T-cells	t-cell	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	rapidly	rapidly	RB	RB	_	17	advmod	_	_
17	declined	decline	VBD	VBD	_	10	conj	_	_
18	following	follow	VBG	VBG	_	20	case	_	_
19	anti-CD3	anti-cd3	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cloning	cloning	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	p27Kip1	p27kip1	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	5	nmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	murine	murine	JJ	JJ	_	12	amod	_	_
11	genomic	genomic	JJ	JJ	_	12	amod	_	_
12	DNA	dna	NN	NN	_	5	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	the	the	DT	DT	_	16	det	_	_
15	functional	functional	JJ	JJ	_	16	amod	_	_
16	analysis	analysis	NN	NN	_	5	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	promoter	promoter	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	p27Kip1	p27kip1	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	consists	consist	VBZ	VBZ	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	at	at	IN	IN	_	6	case	_	_
6	least	least	JJS	JJS	_	7	nmod:npmod	_	_
7	three	three	CD	CD	_	8	nummod	_	_
8	exons	exon	NNS	NNS	_	3	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	spans	span	NNS	NNS	_	3	conj	_	_
11	more	more	RBR	RBR	_	13	advmod	_	_
12	than	than	IN	IN	_	11	mwe	_	_
13	5.6	5.6	CD	CD	_	14	nummod	_	_
14	kb	kb	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	DNA	dna	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Primer	primer	NN	NN	_	2	compound	_	_
2	extension	extension	NN	NN	_	7	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	nuclease	nuclease	NN	NN	_	6	compound	_	_
5	S1	s1	NN	NN	_	6	compound	_	_
6	protection	protection	NN	NN	_	2	conj	_	_
7	analysis	analysis	NN	NN	_	8	nsubj	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	two	two	CD	CD	_	13	nummod	_	_
10	major	major	JJ	JJ	_	13	amod	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	initiation	initiation	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	8	dobj	_	_
14	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	region	region	NN	NN	_	4	nsubj	_	_
4	lacked	lack	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	TATA	tata	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	4	dobj	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	contained	contain	VBD	VBD	_	4	conj	_	_
10	potential	potential	JJ	JJ	_	12	amod	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	sites	site	NNS	NNS	_	9	dobj	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	including	include	VBG	VBG	_	19	case	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	Sp1	sp1	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	CRE	cre	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	Myb	myb	NN	NN	_	19	conj	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	NFkB	nfkb	NN	NN	_	19	conj	_	_
26	located	located	JJ	JJ	_	12	amod	_	_
27	at	at	IN	IN	_	28	case	_	_
28	positions	position	NNS	NNS	_	26	nmod	_	_
29	-153	-153	CD	CD	_	28	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	-178	-178	CD	CD	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	-286	-286	CD	CD	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	-875	-875	CD	CD	_	29	conj	_	_
36	,	,	,	,	_	29	punct	_	_
37	and	and	CC	CC	_	29	cc	_	_
38	-1011	-1011	CD	CD	_	29	conj	_	_
39	,	,	,	,	_	28	punct	_	_
40	respectively	respectively	RB	RB	_	28	advmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	analyze	analyze	VB	VB	_	12	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	controlling	control	VBG	VBG	_	5	acl	_	_
7	p27Kip1	p27kip1	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	characterized	characterize	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	5'-flanking	5'-flanking	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	12	dobj	_	_
16	from	from	IN	IN	_	17	case	_	_
17	nt	nt	NN	NN	_	15	nmod	_	_
18	-1609	-1609	CD	CD	_	17	nummod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	+178	+178	CD	CD	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	-326	-326	CD	CD	_	4	compound	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	-615	-615	CD	CD	_	5	nummod	_	_
5	region	region	NN	NN	_	6	nsubj	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	positive	positive	JJ	JJ	_	9	amod	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	6	dobj	_	_
10	.	.	.	.	_	6	punct	_	_

1	Glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	RANTES	rantes	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	chemokine	chemokine	NN	NN	_	3	compound	_	_
3	RANTES	rantes	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	implicated	implicate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	pathogenesis	pathogenesis	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	allergic	allergic	JJ	JJ	_	13	amod	_	_
12	inflammatory	inflammatory	JJ	JJ	_	13	amod	_	_
13	diseases	disease	NNS	NNS	_	9	nmod	_	_
14	including	include	VBG	VBG	_	15	case	_	_
15	asthma	asthma	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	rhinitis	rhinitis	NN	NN	_	15	conj	_	_
18	which	which	WDT	WDT	_	21	nsubjpass	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	frequently	frequently	RB	RB	_	21	advmod	_	_
21	treated	treat	VBN	VBN	_	15	acl:relcl	_	_
22	with	with	IN	IN	_	23	case	_	_
23	glucocorticoids	glucocorticoid	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	dexamethasone	dexamethasone	NN	NN	_	6	nsubj	_	_
5	dramatically	dramatically	RB	RB	_	6	advmod	_	_
6	inhibited	inhibit	VBD	VBD	_	2	ccomp	_	_
7	RANTES	rantes	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	dose	dose	NN	NN	_	11	dep	_	_
11	dependently	dependently	RB	RB	_	6	advmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	anti-CD3	anti-cd3	NN	NN	_	14	nmod:npmod	_	_
14	activated	activated	JJ	JJ	_	17	amod	_	_
15	Hut-78	hut-78	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	6	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	PBMCs	pbmc	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	RANTES	rante	NNS	NNS	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	appear	appear	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	secondary	secondary	JJ	JJ	_	7	xcomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	inhibition	inhibition	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	required	require	VBD	VBD	_	7	conj	_	_
16	binding	bind	VBG	VBG	_	15	dobj	_	_
17	to	to	TO	TO	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	down-regulation	down-regulation	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	RANTES	rantes	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	directly	directly	RB	RB	_	13	advmod	_	_
13	contribute	contribute	VB	VB	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	efficacy	efficacy	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	agents	agent	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	suppressing	suppress	VBG	VBG	_	16	acl	_	_
22	cellular	cellular	JJ	JJ	_	23	amod	_	_
23	infiltration	infiltration	NN	NN	_	21	dobj	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	to	to	TO	TO	_	28	case	_	_
26	their	they	PRP$	PRP$	_	28	nmod:poss	_	_
27	anti-inflammatory	anti-inflammatory	JJ	JJ	_	28	amod	_	_
28	properties	property	NNS	NNS	_	16	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	state	state	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	maturation	maturation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
7	into	into	IN	IN	_	8	case	_	_
8	macrophages	macrophage	NNS	NNS	_	4	nmod	_	_
9	determines	determine	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-4	il-4	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IL-13	il-13	NN	NN	_	13	conj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	HIV	hiv	NN	NN	_	18	compound	_	_
18	replication	replication	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	27	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-4	il-4	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-13	il-13	NN	NN	_	8	conj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	infection	infection	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
17	as	as	IN	IN	_	19	mark	_	_
18	they	they	PRP	PRP	_	19	nsubj	_	_
19	matured	mature	VBD	VBD	_	27	dep	_	_
20	into	into	IN	IN	_	22	case	_	_
21	monocyte-derived	monocyte-derived	JJ	JJ	_	22	amod	_	_
22	macrophages	macrophage	NNS	NNS	_	19	nmod	_	_
23	over	over	IN	IN	_	25	case	_	_
24	7	7	CD	CD	_	25	nummod	_	_
25	days	day	NNS	NNS	_	19	nmod	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	investigated	investigate	VBN	VBN	_	0	root	_	_
28	using	use	VBG	VBG	_	27	xcomp	_	_
29	HIV-1	hiv-1	NN	NN	_	28	dobj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	BaL	bal	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	29	punct	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	low	low	JJ	JJ	_	38	amod	_	_
36	passage	passage	NN	NN	_	38	compound	_	_
37	clinical	clinical	JJ	JJ	_	38	amod	_	_
38	strains	strain	NNS	NNS	_	29	conj	_	_
39	.	.	.	.	_	27	punct	_	_

1	IL-4	il-4	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-13	il-13	NN	NN	_	1	conj	_	_
4	up-regulated	up-regulate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	genomic	genomic	JJ	JJ	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	spliced	splice	VBN	VBN	_	9	conj	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	9	dep	_	_
14	in	in	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
16	cultured	culture	VBN	VBN	_	15	acl	_	_
17	on	on	IN	IN	_	18	case	_	_
18	Teflon	teflon	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	as	as	IN	IN	_	21	mark	_	_
21	determined	determine	VBN	VBN	_	4	advcl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	Northern	northern	NN	NN	_	24	compound	_	_
24	analysis	analysis	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	p24	p24	NN	NN	_	27	compound	_	_
27	Ag	ag	NN	NN	_	28	compound	_	_
28	assay	assay	NN	NN	_	24	conj	_	_
29	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	5	det	_	_
3	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
4	run-on	run-on	JJ	JJ	_	5	amod	_	_
5	assay	assay	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	IL-4	il-4	NN	NN	_	8	compound	_	_
8	stimulation	stimulation	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	1	parataxis	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	enhance	enhance	VB	VB	_	10	xcomp	_	_
13	transcription	transcription	NN	NN	_	12	dobj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	two-	two-	CD	CD	_	12	nmod	_	_
16	to	to	TO	TO	_	15	dep	_	_
17	threefold	threefold	RB	RB	_	15	advmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	stimulated	stimulate	VBD	VBD	_	0	root	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factor-kappaB	factor-kappab	NN	NN	_	2	dobj	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	translocation	translocation	NN	NN	_	4	dep	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	binding	binding	NN	NN	_	4	conj	_	_
9	before	before	IN	IN	_	10	case	_	_
10	enhancement	enhancement	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	RNA	rna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Conversely	conversely	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	IL-4	il-4	NN	NN	_	9	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-13	il-13	NN	NN	_	3	conj	_	_
6	markedly	markedly	RB	RB	_	7	advmod	_	_
7	and	and	CC	CC	_	9	advmod	_	_
8	significantly	significantly	RB	RB	_	7	advmod	_	_
9	inhibited	inhibit	VBD	VBD	_	0	root	_	_
10	HIV	hiv	NN	NN	_	11	compound	_	_
11	replication	replication	NN	NN	_	9	dobj	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	monocyte-derived	monocyte-derived	JJ	JJ	_	18	amod	_	_
18	macrophages	macrophage	NNS	NNS	_	11	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	this	this	DT	DT	_	22	nsubj	_	_
22	occurred	occur	VBD	VBD	_	9	conj	_	_
23	whether	whether	IN	IN	_	27	mark	_	_
24	these	these	DT	DT	_	25	det	_	_
25	cytokines	cytokine	NNS	NNS	_	27	nsubjpass	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	added	add	VBN	VBN	_	22	ccomp	_	_
28	before	before	IN	IN	_	32	nmod	_	_
29	or	or	CC	CC	_	32	cc	_	_
30	after	after	IN	IN	_	32	conj	_	_
31	HIV	hiv	NN	NN	_	32	compound	_	_
32	infection	infection	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reversal	reversal	NN	NN	_	7	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	stimulation	stimulation	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	case	_	_
6	inhibition	inhibition	NN	NN	_	2	nmod	_	_
7	occurred	occur	VBD	VBD	_	0	root	_	_
8	after	after	IN	IN	_	12	case	_	_
9	3	3	CD	CD	_	11	compound	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	5	5	CD	CD	_	12	nummod	_	_
12	days	day	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	adherence	adherence	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	plastic	plastic	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	2	dobj	_	_
6	on	on	IN	IN	_	9	case	_	_
7	HIV	hiv	NN	NN	_	9	compound	_	_
8	reverse	reverse	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	28	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	DT	DT	_	5	dep	_	_
5	cytokines	cytokine	NNS	NNS	_	2	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	monocyte	monocyte	NN	NN	_	9	compound	_	_
9	maturation/differentiation	maturation/differentiation	NN	NN	_	2	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CD11b	cd11b	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	CD13	cd13	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	CD26	cd26	NN	NN	_	11	conj	_	_
17	)	)	-RRB-	-RRB-	_	11	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	other	other	JJ	JJ	_	21	amod	_	_
20	macrophage	macrophage	NN	NN	_	21	compound	_	_
21	markers	marker	NNS	NNS	_	9	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CD14	cd14	NN	NN	_	21	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	CD68	cd68	NN	NN	_	23	conj	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	examined	examine	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	enhanced	enhance	VBD	VBD	_	0	root	_	_
3	CD11b	cd11b	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	2	punct	_	_
5	but	but	CC	CC	_	2	cc	_	_
6	inhibited	inhibit	VBD	VBD	_	2	conj	_	_
7	CD26	cd26	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	delayed	delay	VBD	VBD	_	6	conj	_	_
11	CD13	cd13	NN	NN	_	12	compound	_	_
12	loss	loss	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	2	punct	_	_

1	IL-13	il-13	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	similar	similar	JJ	JJ	_	4	amod	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	on	on	IN	IN	_	6	case	_	_
6	CD11b	cd11b	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CD13	cd13	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	but	but	CC	CC	_	4	cc	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	effect	effect	NN	NN	_	4	conj	_	_
13	on	on	IN	IN	_	14	case	_	_
14	CD26	cd26	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Hence	hence	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	cytokines	cytokine	NNS	NNS	_	8	nsubj	_	_
5	do	do	VBP	VBP	_	8	aux	_	_
6	not	not	RB	RB	_	8	neg	_	_
7	simply	simply	RB	RB	_	8	advmod	_	_
8	enhance	enhance	VB	VB	_	0	root	_	_
9	monocyte	monocyte	NN	NN	_	10	compound	_	_
10	differentiation	differentiation	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	8	punct	_	_
12	but	but	CC	CC	_	8	cc	_	_
13	have	have	VBP	VBP	_	8	conj	_	_
14	complex	complex	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	slightly	slightly	RB	RB	_	17	advmod	_	_
17	divergent	divergent	JJ	JJ	_	14	conj	_	_
18	effects	effect	NNS	NNS	_	13	dobj	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	impact	impact	VBP	VBP	_	18	acl:relcl	_	_
21	on	on	IN	IN	_	23	case	_	_
22	HIV	hiv	NN	NN	_	23	compound	_	_
23	replication	replication	NN	NN	_	20	nmod	_	_
24	probably	probably	RB	RB	_	28	advmod	_	_
25	through	through	IN	IN	_	28	case	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	signaling	signaling	NN	NN	_	28	compound	_	_
28	pathways	pathway	NNS	NNS	_	20	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	factor-kappaB	factor-kappab	NN	NN	_	32	compound	_	_
32	translocation	translocation	NN	NN	_	28	conj	_	_
33	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	SP-1	sp-1	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	11	nsubj	_	_
5	in	in	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	interleukin-1	interleukin-1	NN	NN	_	10	compound	_	_
9	beta	beta	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	4	nmod	_	_
11	confers	confer	VBZ	VBZ	_	0	root	_	_
12	preferential	preferential	JJ	JJ	_	14	amod	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	keratinocytes	keratinocyte	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	18	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	interleukin-1beta	interleukin-1beta	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-1beta	il-1beta	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	15	case	_	_
14	non-monocytic	non-monocytic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	constructed	construct	VBD	VBD	_	0	root	_	_
19	a	a	DT	DT	_	20	det	_	_
20	series	series	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	plasmids	plasmid	NNS	NNS	_	20	nmod	_	_
24	with	with	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	bacterial	bacterial	JJ	JJ	_	29	amod	_	_
27	chloramphenicol	chloramphenicol	NN	NN	_	29	compound	_	_
28	acetyltransferase	acetyltransferase	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	23	nmod	_	_
30	linked	link	VBN	VBN	_	29	acl	_	_
31	to	to	TO	TO	_	33	case	_	_
32	various	various	JJ	JJ	_	33	amod	_	_
33	parts	part	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	human	human	JJ	JJ	_	38	amod	_	_
37	IL-1beta	il-1beta	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	33	nmod	_	_
39	and	and	CC	CC	_	18	cc	_	_
40	performed	perform	VBD	VBD	_	18	conj	_	_
41	transient	transient	JJ	JJ	_	43	amod	_	_
42	transfection	transfection	NN	NN	_	43	compound	_	_
43	experiments	experiment	NNS	NNS	_	40	dobj	_	_
44	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	segment	segment	NN	NN	_	2	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	activates	activate	VBZ	VBZ	_	5	acl:relcl	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	most	most	RBS	RBS	_	10	advmod	_	_
10	efficiently	efficiently	RB	RB	_	7	advmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	keratinocytes	keratinocyte	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	19	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSA	emsa	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	with	with	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	43-mer	43-mer	NN	NN	_	11	amod	_	_
11	oligonucleotide	oligonucleotide	NN	NN	_	4	nmod	_	_
12	derived	derive	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	functionally	functionally	RB	RB	_	16	advmod	_	_
16	identified	identify	VBN	VBN	_	18	amod	_	_
17	cis-acting	cis-acting	JJ	JJ	_	18	amod	_	_
18	element	element	NN	NN	_	12	nmod	_	_
19	revealed	reveal	VBD	VBD	_	0	root	_	_
20	specific	specific	JJ	JJ	_	21	amod	_	_
21	complexes	complex	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	19	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	competition	competition	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	23	nmod	_	_
4	with	with	IN	IN	_	9	case	_	_
5	transcription	transcription	NN	NN	_	9	compound	_	_
6	factor	factor	NN	NN	_	9	compound	_	_
7	consensus	consensus	NN	NN	_	9	compound	_	_
8	sequence	sequence	NN	NN	_	9	compound	_	_
9	oligonucleotides	oligonucleotide	NNS	NNS	_	3	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	by	by	IN	IN	_	12	case	_	_
12	immunosupershift	immunosupershift	NN	NN	_	3	conj	_	_
13	,	,	,	,	_	23	punct	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	factor	factor	NN	NN	_	16	compound	_	_
16	SP-1	sp-1	NN	NN	_	23	nsubjpass	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	a	a	DT	DT	_	21	det	_	_
19	closely	closely	RB	RB	_	20	advmod	_	_
20	related	related	JJ	JJ	_	21	amod	_	_
21	protein	protein	NN	NN	_	16	conj	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	shown	show	VBN	VBN	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	bind	bind	VBP	VBP	_	23	xcomp	_	_
26	to	to	TO	TO	_	29	case	_	_
27	this	this	DT	DT	_	29	det	_	_
28	regulatory	regulatory	JJ	JJ	_	29	amod	_	_
29	element	element	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	closest	closest	JJS	JJS	_	3	amod	_	_
3	match	match	NN	NN	_	17	nsubj	_	_
4	to	to	TO	TO	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	known	know	VBN	VBN	_	9	amod	_	_
7	SP-1	sp-1	NN	NN	_	9	compound	_	_
8	consensus	consensus	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	3	nmod	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	respective	respective	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	3	nmod	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	TCCCCTCCCCT	tcccctcccct	NN	NN	_	17	compound	_	_
17	motif	motif	NN	NN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Mutation	mutation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	motif	motif	NN	NN	_	1	nmod	_	_
5	almost	almost	RB	RB	_	6	advmod	_	_
6	completely	completely	RB	RB	_	8	advmod	_	_
7	,	,	,	,	_	8	punct	_	_
8	and	and	CC	CC	_	11	advmod	_	_
9	specifically	specifically	RB	RB	_	8	advmod	_	_
10	,	,	,	,	_	8	punct	_	_
11	abolished	abolish	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	binding	binding	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	low-mobility	low-mobility	JJ	JJ	_	17	amod	_	_
17	complexes	complex	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	led	lead	VBD	VBD	_	11	conj	_	_
20	to	to	TO	TO	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	95	95	CD	CD	_	24	nummod	_	_
23	%	%	NN	NN	_	24	compound	_	_
24	decrease	decrease	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	constitutive	constitutive	JJ	JJ	_	28	amod	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	activation	activation	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	a	a	DT	DT	_	33	det	_	_
31	reporter	reporter	NN	NN	_	33	compound	_	_
32	construct	construct	NN	NN	_	33	compound	_	_
33	IL-1beta	il-1beta	NN	NN	_	28	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	-170/+108	-170/+108	CD	CD	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	11	punct	_	_

1	Likewise	likewise	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	activation	activation	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	this	this	DT	DT	_	7	det	_	_
6	reporter	reporter	NN	NN	_	7	compound	_	_
7	construct	construct	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor-alpha	factor-alpha	NN	NN	_	3	nmod	_	_
12	depended	depend	VBD	VBD	_	0	root	_	_
13	on	on	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	SP-1	sp-1	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	a	a	DT	DT	_	8	det	_	_
6	so-far-unrecognized	so-far-unrecognized	JJ	JJ	_	8	amod	_	_
7	SP-1	sp-1	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	15	nsubj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	IL-1beta	il-1beta	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	8	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	participate	participate	VB	VB	_	3	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	regulation	regulation	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	this	this	DT	DT	_	22	det	_	_
22	gene	gene	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	keratinocytes	keratinocyte	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	1	nmod	_	_
9	with	with	IN	IN	_	13	case	_	_
10	steroid-sensitive	steroid-sensitive	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	steroid-resistant	steroid-resistant	JJ	JJ	_	10	conj	_	_
13	asthma	asthma	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	6	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	Glucocorticoids	glucocorticoid	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	medications	medication	NNS	NNS	_	0	root	_	_
7	used	use	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	control	control	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	airway	airway	NN	NN	_	12	compound	_	_
12	inflammation	inflammation	NN	NN	_	9	dobj	_	_
13	associated	associate	VBN	VBN	_	12	acl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	asthma	asthma	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Synthetic	synthetic	JJ	JJ	_	2	amod	_	_
2	glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubj	_	_
3	vary	vary	VBP	VBP	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	their	they	PRP$	PRP$	_	7	nmod:poss	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	affinity	affinity	NN	NN	_	3	nmod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	GCR	gcr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	3	punct	_	_

1	METHODS	method	NNS	NNS	_	4	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	compared	compare	VBD	VBD	_	0	root	_	_
5	hydrocortisone	hydrocortisone	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	beclomethasone	beclomethasone	NN	NN	_	8	compound	_	_
8	dipropionate	dipropionate	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	triamcinolone	triamcinolone	NN	NN	_	11	compound	_	_
11	acetonide	acetonide	NN	NN	_	5	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	flunisolide	flunisolide	NN	NN	_	5	conj	_	_
14	,	,	,	,	_	5	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	budesonide	budesonide	NN	NN	_	5	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	regard	regard	NN	NN	_	4	nmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	capacity	capacity	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	inhibit	inhibit	VB	VB	_	21	acl	_	_
24	phytohemagglutinin-induced	phytohemagglutinin-induced	JJ	JJ	_	29	amod	_	_
25	peripheral	peripheral	JJ	JJ	_	29	amod	_	_
26	blood	blood	NN	NN	_	29	compound	_	_
27	mononuclear	mononuclear	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	proliferation	proliferation	NN	NN	_	23	dobj	_	_
30	from	from	IN	IN	_	32	case	_	_
31	six	six	CD	CD	_	32	nummod	_	_
32	patients	patient	NNS	NNS	_	4	nmod	_	_
33	with	with	IN	IN	_	35	case	_	_
34	steroid-sensitive	steroid-sensitive	JJ	JJ	_	35	amod	_	_
35	asthma	asthma	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	seven	seven	CD	CD	_	38	nummod	_	_
38	patients	patient	NNS	NNS	_	32	conj	_	_
39	with	with	IN	IN	_	41	case	_	_
40	steroid-resistant	steroid-resistant	JJ	JJ	_	41	amod	_	_
41	asthma	asthma	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	4	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	7	amod	_	_
2	blood	blood	NN	NN	_	7	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	GCR	gcr	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	affinities	affinity	NNS	NNS	_	14	nsubjpass	_	_
8	for	for	IN	IN	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	budesonide	budesonide	NN	NN	_	9	conj	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	determined	determine	VBN	VBN	_	0	root	_	_
15	for	for	IN	IN	_	18	case	_	_
16	both	both	DT	DT	_	18	det	_	_
17	patient	patient	NN	NN	_	18	compound	_	_
18	groups	group	NNS	NNS	_	14	nmod	_	_
19	by	by	IN	IN	_	20	mark	_	_
20	using	use	VBG	VBG	_	14	advcl	_	_
21	a	a	DT	DT	_	24	det	_	_
22	radioligand	radioligand	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	assay	assay	NN	NN	_	20	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Scatchard	scatchard	NN	NN	_	27	compound	_	_
27	analysis	analysis	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	14	punct	_	_

1	RESULTS	result	NNS	NNS	_	6	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	Dose-dependent	dose-dependent	JJ	JJ	_	4	amod	_	_
4	inhibition	inhibition	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	all	all	DT	DT	_	9	det	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	both	both	DT	DT	_	13	det	_	_
12	patient	patient	NN	NN	_	13	compound	_	_
13	groups	group	NNS	NNS	_	6	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	with	with	IN	IN	_	19	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	steroid-resistant	steroid-resistant	JJ	JJ	_	18	amod	_	_
18	group	group	NN	NN	_	19	nsubj	_	_
19	requiring	require	VBG	VBG	_	6	advcl	_	_
20	approximately	approximately	RB	RB	_	21	advmod	_	_
21	2	2	CD	CD	_	24	nummod	_	_
22	log-fold	log-fold	JJ	JJ	_	21	advmod	_	_
23	more	more	JJR	JJR	_	21	advmod	_	_
24	glucocorticoids	glucocorticoid	NNS	NNS	_	19	dobj	_	_
25	for	for	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	equivalent	equivalent	JJ	JJ	_	28	amod	_	_
28	degree	degree	NN	NN	_	19	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	inhibition	inhibition	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mean	mean	NN	NN	_	3	compound	_	_
3	concentrations	concentration	NNS	NNS	_	20	nsubj	_	_
4	necessary	necessary	JJ	JJ	_	3	amod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	cause	cause	VB	VB	_	4	xcomp	_	_
7	50	50	CD	CD	_	9	nummod	_	_
8	%	%	NN	NN	_	9	compound	_	_
9	inhibition	inhibition	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	lymphocyte	lymphocyte	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IC50s	ic50	NNS	NNS	_	9	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	steroid-sensitive	steroid-sensitive	JJ	JJ	_	19	amod	_	_
19	group	group	NN	NN	_	6	nmod	_	_
20	ranged	range	VBD	VBD	_	0	root	_	_
21	from	from	IN	IN	_	25	case	_	_
22	2	2	CD	CD	_	25	nummod	_	_
23	x	x	CC	CC	_	22	cc	_	_
24	10(-10)	10(-10)	CD	CD	_	22	conj	_	_
25	mol/L	mol/l	NN	NN	_	20	nmod	_	_
26	for	for	IN	IN	_	27	case	_	_
27	budesonide	budesonide	NN	NN	_	25	nmod	_	_
28	to	to	TO	TO	_	32	case	_	_
29	7	7	CD	CD	_	32	nummod	_	_
30	x	x	CC	CC	_	29	cc	_	_
31	10(-8)	10(-8)	CD	CD	_	29	conj	_	_
32	mol/L	mol/l	NN	NN	_	25	nmod	_	_
33	for	for	IN	IN	_	34	case	_	_
34	hydrocortisone	hydrocortisone	NN	NN	_	32	nmod	_	_
35	,	,	,	,	_	20	punct	_	_
36	whereas	whereas	IN	IN	_	20	dep	_	_
37	the	the	DT	DT	_	39	det	_	_
38	mean	mean	NN	NN	_	39	compound	_	_
39	IC50s	ic50	NNS	NNS	_	44	nsubj	_	_
40	for	for	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	steroid-resistant	steroid-resistant	JJ	JJ	_	43	amod	_	_
43	group	group	NN	NN	_	39	nmod	_	_
44	ranged	range	VBD	VBD	_	20	parataxis	_	_
45	from	from	IN	IN	_	50	case	_	_
46	approximately	approximately	RB	RB	_	47	advmod	_	_
47	2	2	CD	CD	_	50	nummod	_	_
48	x	x	CC	CC	_	47	cc	_	_
49	10(-8)	10(-8)	CD	CD	_	47	conj	_	_
50	mol/L	mol/l	NN	NN	_	44	nmod	_	_
51	for	for	IN	IN	_	52	case	_	_
52	budesonide	budesonide	NN	NN	_	50	nmod	_	_
53	to	to	TO	TO	_	57	case	_	_
54	greater	greater	JJR	JJR	_	56	advmod	_	_
55	than	than	IN	IN	_	56	advmod	_	_
56	10(-6)	10(-6)	CD	CD	_	57	nummod	_	_
57	mol/L	mol/l	NN	NN	_	50	nmod	_	_
58	for	for	IN	IN	_	59	case	_	_
59	hydrocortisone	hydrocortisone	NN	NN	_	57	nmod	_	_
60	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	noted	note	VBN	VBN	_	0	root	_	_
9	between	between	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	degree	degree	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	inhibition	inhibition	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	lymphocyte	lymphocyte	NN	NN	_	16	compound	_	_
16	proliferation	proliferation	NN	NN	_	13	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IC50	ic50	NN	NN	_	13	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	affinity	affinity	NN	NN	_	11	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	dexamethasone	dexamethasone	NN	NN	_	23	nmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	GCR	gcr	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Patients	patient	NNS	NNS	_	7	nsubjpass	_	_
2	with	with	IN	IN	_	4	case	_	_
3	steroid-resistant	steroid-resistant	JJ	JJ	_	4	amod	_	_
4	asthma	asthma	NN	NN	_	1	nmod	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	have	have	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	14	det	_	_
11	reduced	reduce	VBN	VBN	_	14	amod	_	_
12	GCR	gcr	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	affinity	affinity	NN	NN	_	9	dobj	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	GCR	gcr	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	affinity	affinity	NN	NN	_	9	nsubj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	budesonide	budesonide	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	higher	higher	JJR	JJR	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	groups	group	NNS	NNS	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	18	punct	_	_
14	i.e.	i.e.	FW	FW	_	18	advmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	lower	lower	JJR	JJR	_	18	amod	_	_
17	dissociation	dissociation	NN	NN	_	18	compound	_	_
18	constant	constant	NN	NN	_	9	dobj	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	than	than	IN	IN	_	21	case	_	_
21	that	that	DT	DT	_	9	nmod	_	_
22	obtained	obtain	VBN	VBN	_	21	acl	_	_
23	for	for	IN	IN	_	24	case	_	_
24	dexamethasone	dexamethasone	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	5	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	31	mark	_	_
7	glucocorticoids	glucocorticoid	NNS	NNS	_	31	nsubj	_	_
8	such	such	JJ	JJ	_	10	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	budesonide	budesonide	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	31	punct	_	_
12	by	by	IN	IN	_	19	case	_	_
13	virtue	virtue	NN	NN	_	19	dep	_	_
14	of	of	IN	IN	_	19	case	_	_
15	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
16	high	high	JJ	JJ	_	19	amod	_	_
17	GCR	gcr	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	affinities	affinity	NNS	NNS	_	31	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	greater	greater	JJR	JJR	_	22	amod	_	_
22	ability	ability	NN	NN	_	19	conj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	suppress	suppress	VB	VB	_	22	acl	_	_
25	lymphocyte	lymphocyte	NN	NN	_	26	compound	_	_
26	proliferation	proliferation	NN	NN	_	24	dobj	_	_
27	,	,	,	,	_	31	punct	_	_
28	may	may	MD	MD	_	31	aux	_	_
29	therefore	therefore	RB	RB	_	31	advmod	_	_
30	be	be	VB	VB	_	31	cop	_	_
31	beneficial	beneficial	JJ	JJ	_	5	ccomp	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	management	management	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	difficult-to-control	difficult-to-control	JJ	JJ	_	37	amod	_	_
37	asthma	asthma	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	IgE	ige	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	11	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	0	root	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	binds	bind	VBZ	VBZ	_	11	acl:relcl	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	consensus	consensus	NN	NN	_	18	compound	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	13	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	cis-acting	cis-acting	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	various	various	JJ	JJ	_	25	amod	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	4	nsubj	_	_
4	activates	activate	VBZ	VBZ	_	19	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	many	many	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	6	nmod	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	15	case	_	_
12	immune	immune	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	inflammatory	inflammatory	JJ	JJ	_	12	conj	_	_
15	responses	response	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	little	little	JJ	JJ	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	known	know	VBN	VBN	_	0	root	_	_
20	about	about	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	role	role	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	induction	induction	NN	NN	_	22	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	IgE	ige	NN	NN	_	32	compound	_	_
32	synthesis	synthesis	NN	NN	_	29	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	human	human	JJ	JJ	_	36	amod	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	29	nmod	_	_
37	.	.	.	.	_	19	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	we	we	PRP	PRP	_	4	nsubj	_	_
3	first	first	RB	RB	_	4	advmod	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	participation	participation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	germline	germline	NN	NN	_	14	compound	_	_
12	C	c	NN	NN	_	14	compound	_	_
13	epsilon	epsilon	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	6	nmod	_	_
15	in	in	IN	IN	_	22	case	_	_
16	a	a	DT	DT	_	22	det	_	_
17	human	human	JJ	JJ	_	22	amod	_	_
18	Burkitt	burkitt	NN	NN	_	22	compound	_	_
19	lymphoma	lymphoma	NN	NN	_	22	compound	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	14	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	DND39	dnd39	NN	NN	_	22	appos	_	_
25	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	DND39	dnd39	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IL-4	il-4	NN	NN	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	anti-CD40	anti-cd40	JJ	JJ	_	10	amod	_	_
9	monoclonal	monoclonal	JJ	JJ	_	10	amod	_	_
10	antibody	antibody	NN	NN	_	6	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	mAb	mab	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	activated	activate	VBD	VBD	_	0	root	_	_
15	phosphatidylinositol	phosphatidylinositol	NN	NN	_	16	compound	_	_
16	3-kinase	3-kinase	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	subsequently	subsequently	RB	RB	_	19	advmod	_	_
19	induced	induce	VBD	VBD	_	14	conj	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	which	which	WDT	WDT	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	identified	identify	VBN	VBN	_	21	acl:relcl	_	_
29	by	by	IN	IN	_	33	case	_	_
30	electrophoretic	electrophoretic	JJ	JJ	_	33	amod	_	_
31	mobility	mobility	NN	NN	_	33	compound	_	_
32	shift	shift	NN	NN	_	33	compound	_	_
33	assays	assay	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	14	punct	_	_

1	n-Acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	NAC	nac	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	potent	potent	JJ	JJ	_	8	amod	_	_
8	antioxidant	antioxidant	NN	NN	_	1	appos	_	_
9	,	,	,	,	_	1	punct	_	_
10	blocked	block	VBD	VBD	_	0	root	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	dobj	_	_
14	caused	cause	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	IL-4	il-4	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	by	by	IN	IN	_	20	case	_	_
19	anti-CD40	anti-cd40	JJ	JJ	_	20	amod	_	_
20	mAb	mab	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	inhibition	inhibition	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	IL-4-driven	il-4-driven	JJ	JJ	_	8	amod	_	_
5	germline	germline	NN	NN	_	8	compound	_	_
6	C	c	NN	NN	_	8	compound	_	_
7	epsilon	epsilon	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	2	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	NAC	nac	NN	NN	_	2	nmod	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	sufficient	sufficient	JJ	JJ	_	18	advcl	_	_
14	,	,	,	,	_	18	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	agent	agent	NN	NN	_	18	nsubj	_	_
17	remarkably	remarkably	RB	RB	_	18	advmod	_	_
18	diminished	diminish	VBD	VBD	_	0	root	_	_
19	anti-CD40	anti-cd40	JJ	JJ	_	20	amod	_	_
20	mAb-mediated	mab-mediated	JJ	JJ	_	21	amod	_	_
21	up-regulation	up-regulation	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	germline	germline	NN	NN	_	26	compound	_	_
24	C	c	NN	NN	_	26	compound	_	_
25	epsilon	epsilon	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	Second	second	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NAC	nac	NN	NN	_	6	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	IgE	ige	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	normal	normal	JJ	JJ	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	costimulated	costimulate	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	IL-4	il-4	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	anti-CD40	anti-cd40	JJ	JJ	_	22	amod	_	_
22	mAb	mab	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	NAC	nac	NN	NN	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	effective	effective	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	5	mark	_	_
5	inhibiting	inhibit	VBG	VBG	_	3	advcl	_	_
6	mature	mature	JJ	JJ	_	9	amod	_	_
7	C	c	NN	NN	_	9	compound	_	_
8	epsilon	epsilon	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IgE	ige	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	9	conj	_	_
13	in	in	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	T	t	NN	NN	_	16	nmod:npmod	_	_
16	cell-independent	cell-independent	JJ	JJ	_	18	amod	_	_
17	culture	culture	NN	NN	_	18	compound	_	_
18	system	system	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	NAC	nac	NN	NN	_	7	nsubj	_	_
4	did	do	VBD	VBD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	affect	affect	VB	VB	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	spontaneous	spontaneous	JJ	JJ	_	10	amod	_	_
10	production	production	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IgE	ige	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	atopic	atopic	JJ	JJ	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	10	nsubj	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	commonly	commonly	RB	RB	_	10	advmod	_	_
10	inducible	inducible	JJ	JJ	_	3	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	DND39	dnd39	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	IL-4	il-4	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	anti-CD40	anti-cd40	JJ	JJ	_	18	amod	_	_
18	mAb	mab	NN	NN	_	15	conj	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	suggest	suggest	VBP	VBP	_	3	conj	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	28	nsubj	_	_
24	sensitive	sensitive	JJ	JJ	_	23	amod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	NAC	nac	NN	NN	_	24	nmod	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	play	play	VB	VB	_	20	ccomp	_	_
29	a	a	DT	DT	_	30	det	_	_
30	role	role	NN	NN	_	28	dobj	_	_
31	in	in	IN	IN	_	32	mark	_	_
32	regulating	regulate	VBG	VBG	_	28	advcl	_	_
33	IgE	ige	NN	NN	_	34	compound	_	_
34	synthesis	synthesis	NN	NN	_	32	dobj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	age-related	age-related	JJ	JJ	_	7	amod	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	dysfunction	dysfunction	NN	NN	_	3	nmod	_	_
8	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	Aging	aging	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	classically	classically	RB	RB	_	4	advmod	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	dysregulation	dysregulation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	immunologic	immunologic	JJ	JJ	_	11	amod	_	_
11	machinery	machinery	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	consequence	consequence	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	immune	immune	JJ	JJ	_	7	amod	_	_
7	response	response	NN	NN	_	14	nsubj	_	_
8	developed	develop	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	senescent	senescent	JJ	JJ	_	11	amod	_	_
11	organisms	organism	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	usually	usually	RB	RB	_	14	advmod	_	_
14	inappropriate	inappropriate	JJ	JJ	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	often	often	RB	RB	_	17	advmod	_	_
17	inefficient	inefficient	JJ	JJ	_	14	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	sometimes	sometimes	RB	RB	_	20	advmod	_	_
20	aberrant	aberrant	JJ	JJ	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	potentially	potentially	RB	RB	_	24	advmod	_	_
24	detrimental	detrimental	JJ	JJ	_	14	conj	_	_
25	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	age-associated	age-associated	JJ	JJ	_	4	amod	_	_
3	immune	immune	JJ	JJ	_	4	amod	_	_
4	dysfunction	dysfunction	NN	NN	_	7	nsubjpass	_	_
5	may	may	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	implicated	implicate	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	some	some	DT	DT	_	10	det	_	_
10	degree	degree	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	extreme	extreme	JJ	JJ	_	14	amod	_	_
14	susceptibility	susceptibility	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	elderly	elderly	JJ	JJ	_	14	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	infection	infection	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	neoplasia	neoplasia	NN	NN	_	19	conj	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	may	may	MD	MD	_	25	aux	_	_
24	even	even	RB	RB	_	25	advmod	_	_
25	participate	participate	VB	VB	_	7	conj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	various	various	JJ	JJ	_	28	amod	_	_
28	aspects	aspect	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	senescence	senescence	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	understanding	understanding	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	3	nmod	_	_
8	underlying	underlie	VBG	VBG	_	7	acl	_	_
9	immunosenescence	immunosenescence	NN	NN	_	8	dobj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	still	still	RB	RB	_	12	advmod	_	_
12	fragmentary	fragmentary	JJ	JJ	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	most	most	RBS	RBS	_	3	advmod	_	_
3	extensively	extensively	RB	RB	_	4	advmod	_	_
4	studied	study	VBN	VBN	_	5	amod	_	_
5	phenomenon	phenomenon	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	the	the	DT	DT	_	9	det	_	_
8	progressive	progressive	JJ	JJ	_	9	amod	_	_
9	decline	decline	NN	NN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	proliferative	proliferative	JJ	JJ	_	13	amod	_	_
13	capacities	capacity	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	aging	aging	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	loss	loss	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	proliferative	proliferative	JJ	JJ	_	5	amod	_	_
5	potential	potential	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	response	response	NN	NN	_	10	dep	_	_
8	to	to	TO	TO	_	10	case	_	_
9	antigenic	antigenic	JJ	JJ	_	10	amod	_	_
10	challenge	challenge	NN	NN	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	characteristic	characteristic	JJ	JJ	_	14	amod	_	_
14	feature	feature	NN	NN	_	0	root	_	_
15	of	of	IN	IN	_	17	case	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	senescence	senescence	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	directly	directly	RB	RB	_	4	advmod	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	emergence	emergence	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	age-related	age-related	JJ	JJ	_	12	amod	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	deficiency	deficiency	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	review	review	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	show	show	VB	VB	_	6	xcomp	_	_
9	how	how	WRB	WRB	_	19	advmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	accumulation	accumulation	NN	NN	_	19	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	various	various	JJ	JJ	_	15	amod	_	_
14	biochemical	biochemical	JJ	JJ	_	15	amod	_	_
15	lesions	lesion	NNS	NNS	_	11	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	advancing	advance	VBG	VBG	_	18	amod	_	_
18	age	age	NN	NN	_	11	nmod	_	_
19	leads	lead	VBZ	VBZ	_	8	ccomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	failure	failure	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	critical	critical	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	function	function	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	namely	namely	RB	RB	_	27	advmod	_	_
30	the	the	DT	DT	_	33	det	_	_
31	activation-induced	activation-induced	JJ	JJ	_	33	amod	_	_
32	lymphocyte	lymphocyte	NN	NN	_	33	compound	_	_
33	proliferation	proliferation	NN	NN	_	27	dep	_	_
34	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biochemical	biochemical	JJ	JJ	_	3	amod	_	_
3	modifications	modification	NNS	NNS	_	17	nsubjpass	_	_
4	responsible	responsible	JJ	JJ	_	3	amod	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	defect	defect	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	transduction	transduction	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	execution	execution	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	proliferative	proliferative	JJ	JJ	_	15	amod	_	_
15	signal	signal	NN	NN	_	9	nmod	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	analyzed	analyze	VBN	VBN	_	0	root	_	_
18	as	as	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	function	function	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	age	age	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	multiple	multiple	JJ	JJ	_	3	amod	_	_
3	alterations	alteration	NNS	NNS	_	11	nsubj	_	_
4	observed	observe	VBN	VBN	_	3	acl	_	_
5	on	on	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	various	various	JJ	JJ	_	9	amod	_	_
8	biochemical	biochemical	JJ	JJ	_	9	amod	_	_
9	pathways	pathway	NNS	NNS	_	4	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	appear	appear	VB	VB	_	0	root	_	_
12	as	as	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	consequence	consequence	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	unique	unique	JJ	JJ	_	19	amod	_	_
18	deleterious	deleterious	JJ	JJ	_	19	amod	_	_
19	mechanism	mechanism	NN	NN	_	14	nmod	_	_
20	more	more	RBR	RBR	_	21	advmod	_	_
21	fundamentally	fundamentally	RB	RB	_	22	advmod	_	_
22	related	related	JJ	JJ	_	19	amod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	process	process	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	senescence	senescence	NN	NN	_	25	nmod	_	_
28	such	such	JJ	JJ	_	31	case	_	_
29	as	as	IN	IN	_	28	mwe	_	_
30	the	the	DT	DT	_	31	det	_	_
31	inability	inability	NN	NN	_	27	nmod	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	cope	cope	VB	VB	_	31	acl	_	_
34	with	with	IN	IN	_	36	case	_	_
35	oxidative	oxidative	JJ	JJ	_	36	amod	_	_
36	stress	stress	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	Engagement	engagement	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	Lewis	lewis	NN	NN	_	6	compound	_	_
5	X	x	NN	NN	_	6	compound	_	_
6	antigen	antigen	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CD15	cd15	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	results	result	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	monocyte	monocyte	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	monocyte	monocyte	NN	NN	_	6	compound	_	_
6	adhesion	adhesion	NN	NN	_	17	nsubj	_	_
7	to	to	TO	TO	_	16	case	_	_
8	tumor	tumor	NN	NN	_	16	compound	_	_
9	necrosis	necrosis	NN	NN	_	16	compound	_	_
10	factor-alpha	factor-alpha	NN	NN	_	16	compound	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	16	compound	_	_
13	)	)	-RRB-	-RRB-	_	16	punct	_	_
14	-treated	-treated	JJ	JJ	_	16	amod	_	_
15	endothelial	endothelial	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	6	nmod	_	_
17	increased	increase	VBD	VBD	_	3	ccomp	_	_
18	expression	expression	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	tissue	tissue	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	CD36	cd36	NN	NN	_	21	conj	_	_
24	on	on	IN	IN	_	25	case	_	_
25	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	immunological	immunological	JJ	JJ	_	3	amod	_	_
3	cross-linking	cross-linking	NN	NN	_	1	dobj	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	mimic	mimic	VB	VB	_	1	advcl	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	engagement	engagement	NN	NN	_	5	dobj	_	_
8	by	by	IN	IN	_	10	case	_	_
9	natural	natural	JJ	JJ	_	10	amod	_	_
10	ligands	ligand	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	1	punct	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	now	now	RB	RB	_	14	advmod	_	_
14	show	show	VBP	VBP	_	1	parataxis	_	_
15	that	that	IN	IN	_	29	mark	_	_
16	CD15	cd15	NN	NN	_	29	nsubj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	Lewis	lewis	NN	NN	_	19	compound	_	_
19	X	x	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	16	punct	_	_
22	a	a	DT	DT	_	24	det	_	_
23	monocyte	monocyte	NN	NN	_	24	compound	_	_
24	counter-receptor	counter-receptor	NN	NN	_	16	appos	_	_
25	for	for	IN	IN	_	27	case	_	_
26	endothelial	endothelial	JJ	JJ	_	27	amod	_	_
27	selectins	selectin	NNS	NNS	_	24	nmod	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	participate	participate	VB	VB	_	14	ccomp	_	_
30	in	in	IN	IN	_	32	case	_	_
31	this	this	DT	DT	_	32	det	_	_
32	response	response	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	2	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	readout	readout	NN	NN	_	2	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	monocyte	monocyte	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	2	cc	_	_
12	found	find	VBD	VBD	_	2	conj	_	_
13	that	that	IN	IN	_	16	mark	_	_
14	CD15	cd15	NN	NN	_	15	compound	_	_
15	cross-linking	cross-linking	NN	NN	_	16	nsubj	_	_
16	induced	induce	VBD	VBD	_	12	ccomp	_	_
17	TNF-alpha	tnf-alpha	NN	NN	_	18	compound	_	_
18	release	release	NN	NN	_	16	dobj	_	_
19	from	from	IN	IN	_	22	case	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	cells	cell	NNS	NNS	_	18	conj	_	_
25	from	from	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	monocytic	monocytic	JJ	JJ	_	30	amod	_	_
28	cell	cell	NN	NN	_	30	compound	_	_
29	line	line	NN	NN	_	30	compound	_	_
30	MM6	mm6	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	Quantitative	quantitative	JJ	JJ	_	5	amod	_	_
2	reverse	reverse	JJ	JJ	_	5	amod	_	_
3	transcriptase-polymerase	transcriptase-polymerase	JJ	JJ	_	5	amod	_	_
4	chain	chain	NN	NN	_	5	compound	_	_
5	reaction	reaction	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	RT-PCR	rt-pcr	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	an	a	DT	DT	_	11	det	_	_
11	increase	increase	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	steady-state	steady-state	JJ	JJ	_	15	amod	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	15	compound	_	_
15	mRNA	mrna	NN	NN	_	11	nmod	_	_
16	after	after	IN	IN	_	20	case	_	_
17	3	3	CD	CD	_	19	compound	_	_
18	to	to	TO	TO	_	19	dep	_	_
19	4	4	CD	CD	_	20	nummod	_	_
20	hours	hour	NNS	NNS	_	9	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	cross-linking	cross-linking	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	CD15	cd15	NN	NN	_	2	compound	_	_
2	cross-linking	cross-linking	NN	NN	_	5	nsubj	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	concomitantly	concomitantly	RB	RB	_	5	advmod	_	_
5	increased	increase	VBD	VBD	_	0	root	_	_
6	interleukin-1	interleukin-1	NN	NN	_	12	compound	_	_
7	beta	beta	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	IL-1	il-1	NN	NN	_	12	compound	_	_
10	beta	beta	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	mRNA	mrna	NN	NN	_	5	dobj	_	_
13	,	,	,	,	_	5	punct	_	_
14	while	while	IN	IN	_	19	mark	_	_
15	no	no	DT	DT	_	17	neg	_	_
16	apparent	apparent	JJ	JJ	_	17	amod	_	_
17	change	change	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	observed	observe	VBN	VBN	_	5	advcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	levels	level	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	beta-actin	beta-actin	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	19	punct	_	_
27	indicating	indicate	VBG	VBG	_	5	xcomp	_	_
28	specificity	specificity	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	0	root	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	regulation	regulation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	CD15	cd15	NN	NN	_	10	compound	_	_
10	engagement	engagement	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	a	a	DT	DT	_	16	det	_	_
13	CAT	cat	NN	NN	_	16	compound	_	_
14	plasmid	plasmid	NN	NN	_	16	compound	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	construct	construct	NN	NN	_	23	nsubjpass	_	_
17	containing	contain	VBG	VBG	_	16	acl	_	_
18	IL-1	il-1	NN	NN	_	21	compound	_	_
19	beta	beta	NN	NN	_	21	compound	_	_
20	promoter/enhancer	promoter/enhancer	NN	NN	_	21	compound	_	_
21	sequences	sequence	NNS	NNS	_	17	dobj	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	introduced	introduce	VBN	VBN	_	2	parataxis	_	_
24	into	into	IN	IN	_	25	case	_	_
25	MM6	mm6	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Subsequent	subsequent	JJ	JJ	_	2	amod	_	_
2	cross-linking	cross-linking	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CD15	cd15	NN	NN	_	2	nmod	_	_
5	increased	increase	VBD	VBD	_	0	root	_	_
6	CAT	cat	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	5	dobj	_	_
8	.	.	.	.	_	5	punct	_	_

1	CD15	cd15	NN	NN	_	2	compound	_	_
2	engagement	engagement	NN	NN	_	7	nsubj	_	_
3	by	by	IN	IN	_	5	case	_	_
4	monoclonal	monoclonal	JJ	JJ	_	5	amod	_	_
5	antibody	antibody	NN	NN	_	2	nmod	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	attenuated	attenuate	VBD	VBD	_	0	root	_	_
8	IL-1	il-1	NN	NN	_	9	compound	_	_
9	beta	beta	NN	NN	_	11	compound	_	_
10	transcript	transcript	NN	NN	_	11	compound	_	_
11	degradation	degradation	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	7	punct	_	_
13	demonstrating	demonstrate	VBG	VBG	_	7	advcl	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	signaling	signaling	NN	NN	_	19	nsubj	_	_
16	via	via	IN	IN	_	17	case	_	_
17	CD15	cd15	NN	NN	_	15	nmod	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	had	have	VBD	VBD	_	13	ccomp	_	_
20	posttranscriptional	posttranscriptional	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	7	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	extracts	extract	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	anti-CD15	anti-cd15	JJ	JJ	_	6	amod	_	_
5	cross-linked	cross-linked	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	enhanced	enhance	VBN	VBN	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	activator	activator	NN	NN	_	15	compound	_	_
15	protein-1	protein-1	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	minimally	minimally	RB	RB	_	18	advmod	_	_
18	changed	change	VBD	VBD	_	7	conj	_	_
19	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
20	factor-kappa	factor-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	dobj	_	_
22	,	,	,	,	_	7	punct	_	_
23	and	and	CC	CC	_	7	cc	_	_
24	did	do	VBD	VBD	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	affect	affect	VB	VB	_	7	conj	_	_
27	SV40	sv40	NN	NN	_	30	compound	_	_
28	promoter	promoter	NN	NN	_	30	compound	_	_
29	specific	specific	JJ	JJ	_	30	amod	_	_
30	protein-1	protein-1	NN	NN	_	26	dobj	_	_
31	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	engagement	engagement	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CD15	cd15	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
9	results	result	VBZ	VBZ	_	2	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	monocyte	monocyte	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	to	to	TO	TO	_	7	case	_	_
4	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
5	well-recognized	well-recognized	JJ	JJ	_	7	amod	_	_
6	adhesive	adhesive	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	CD15	cd15	NN	NN	_	11	nsubj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	function	function	VB	VB	_	0	root	_	_
12	as	as	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	important	important	JJ	JJ	_	16	amod	_	_
15	signaling	signal	VBG	VBG	_	16	amod	_	_
16	molecule	molecule	NN	NN	_	11	nmod	_	_
17	capable	capable	JJ	JJ	_	16	amod	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	initiating	initiate	VBG	VBG	_	17	advcl	_	_
20	proinflammatory	proinflammatory	JJ	JJ	_	21	amod	_	_
21	events	event	NNS	NNS	_	19	dobj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	come	come	VBP	VBP	_	23	acl:relcl	_	_
26	into	into	IN	IN	_	27	case	_	_
27	contact	contact	NN	NN	_	25	nmod	_	_
28	with	with	IN	IN	_	30	case	_	_
29	activated	activate	VBN	VBN	_	30	amod	_	_
30	endothelium	endothelium	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	11	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	signaling	signaling	NN	NN	_	4	compound	_	_
4	pathways	pathway	NNS	NNS	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	prevention	prevention	NN	NN	_	1	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	cytokines	cytokine	NNS	NNS	_	1	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	eosinophils	eosinophil	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Inhibition	inhibition	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	apoptosis	apoptosis	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	5	case	_	_
5	eosinophils	eosinophil	NNS	NNS	_	3	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	cytokines	cytokine	NNS	NNS	_	1	nmod	_	_
8	such	such	JJ	JJ	_	10	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	IL-5	il-5	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	GM-CSF	gm-csf	NN	NN	_	10	conj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	play	play	VB	VB	_	0	root	_	_
15	an	a	DT	DT	_	17	det	_	_
16	important	important	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	pathogenesis	pathogenesis	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	allergic	allergic	JJ	JJ	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	parasitic	parasitic	JJ	JJ	_	22	conj	_	_
25	disorders	disorder	NNS	NNS	_	22	dep	_	_
26	.	.	.	.	_	14	punct	_	_

1	Recently	recently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	there	there	EX	EX	_	7	expl	_	_
4	has	have	VBZ	VBZ	_	7	aux	_	_
5	been	be	VBN	VBN	_	7	cop	_	_
6	some	some	DT	DT	_	7	det	_	_
7	progress	progress	NN	NN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	understanding	understanding	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	signal	signal	NN	NN	_	15	compound	_	_
14	transduction	transduction	NN	NN	_	15	compound	_	_
15	pathways	pathway	NNS	NNS	_	10	nmod	_	_
16	activated	activate	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	eosinophils	eosinophil	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	IL-3	il-3	NN	NN	_	8	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	IL-5	il-5	NN	NN	_	2	conj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	GM-CSF	gm-csf	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	2	conj	_	_
8	share	share	VBP	VBP	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	common	common	JJ	JJ	_	12	amod	_	_
11	signal	signal	NN	NN	_	12	compound	_	_
12	transducer	transducer	NN	NN	_	8	dobj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	possesses	possess	VBZ	VBZ	_	12	acl:relcl	_	_
15	no	no	DT	DT	_	18	neg	_	_
16	intrinsic	intrinsic	JJ	JJ	_	18	amod	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	eosinophil	eosinophil	NN	NN	_	7	compound	_	_
7	stimulation	stimulation	NN	NN	_	12	nsubjpass	_	_
8	by	by	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	cytokines	cytokine	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	4	ccomp	_	_
13	with	with	IN	IN	_	14	case	_	_
14	increases	increase	NNS	NNS	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	phosphorylation	phosphorylation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	several	several	JJ	JJ	_	21	amod	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	substrates	substrate	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	past	past	JJ	JJ	_	5	amod	_	_
4	few	few	JJ	JJ	_	5	amod	_	_
5	years	year	NNS	NNS	_	11	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	there	there	EX	EX	_	11	expl	_	_
8	has	have	VBZ	VBZ	_	11	aux	_	_
9	been	be	VBN	VBN	_	11	cop	_	_
10	some	some	DT	DT	_	11	det	_	_
11	progress	progress	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	defining	define	VBG	VBG	_	11	acl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	kinases	kinase	NNS	NNS	_	13	dobj	_	_
17	that	that	WDT	WDT	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	activated	activate	VBN	VBN	_	16	acl:relcl	_	_
20	by	by	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	IL-3/IL-5/GM-CSF	il-3/il-5/gm-csf	NN	NN	_	24	compound	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	beta-subunit	beta-subunit	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	eosinophils	eosinophil	NNS	NNS	_	24	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	4	nsubj	_	_
3	will	will	MD	MD	_	4	aux	_	_
4	concentrate	concentrate	VB	VB	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	topic	topic	JJ	JJ	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	on	on	IN	IN	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	role	role	NN	NN	_	7	conj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	eosinophil	eosinophil	NN	NN	_	17	compound	_	_
17	apoptosis	apoptosis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	human	human	JJ	JJ	_	7	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	zinc	zinc	NN	NN	_	1	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	related	related	JJ	JJ	_	12	amod	_	_
12	cations	cation	NNS	NNS	_	9	conj	_	_
13	.	.	.	.	_	1	punct	_	_

1	Zinc	zinc	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	important	important	JJ	JJ	_	6	amod	_	_
5	trace	trace	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	function	function	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	zinc	zinc	NN	NN	_	7	compound	_	_
7	addition	addition	NN	NN	_	16	nsubj	_	_
8	in	in	IN	IN	_	15	case	_	_
9	a	a	DT	DT	_	15	det	_	_
10	serum-	serum-	NN	NN	_	15	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	lipopolysaccharide-free	lipopolysaccharide-free	JJ	JJ	_	10	conj	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	culture	culture	NN	NN	_	15	compound	_	_
15	system	system	NN	NN	_	7	nmod	_	_
16	leads	lead	VBZ	VBZ	_	4	ccomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	significantly	significantly	RB	RB	_	19	advmod	_	_
19	enhanced	enhanced	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	interleukin	interleukin	NN	NN	_	24	compound	_	_
23	1	1	CD	CD	_	24	nummod	_	_
24	beta	beta	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	IL-1	il-1	NN	NN	_	27	compound	_	_
27	beta	beta	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	tumour	tumour	NN	NN	_	33	compound	_	_
31	necrosis	necrosis	NN	NN	_	33	compound	_	_
32	factor	factor	NN	NN	_	33	compound	_	_
33	alpha	alpha	NN	NN	_	24	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	TNF-alpha	tnf-alpha	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	and	and	CC	CC	_	20	cc	_	_
38	to	to	TO	TO	_	39	case	_	_
39	expression	expression	NN	NN	_	20	conj	_	_
40	of	of	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	corresponding	corresponding	JJ	JJ	_	43	amod	_	_
43	mRNA	mrna	NN	NN	_	39	nmod	_	_
44	in	in	IN	IN	_	49	case	_	_
45	human	human	JJ	JJ	_	49	amod	_	_
46	peripheral	peripheral	JJ	JJ	_	49	amod	_	_
47	blood	blood	NN	NN	_	49	compound	_	_
48	mononuclear	mononuclear	JJ	JJ	_	49	amod	_	_
49	cells	cell	NNS	NNS	_	43	nmod	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	PBMC	pbmc	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	4	punct	_	_

1	Structurally	structurally	RB	RB	_	2	advmod	_	_
2	related	related	JJ	JJ	_	4	amod	_	_
3	divalent	divalent	JJ	JJ	_	4	amod	_	_
4	cations	cation	NNS	NNS	_	14	nsubj	_	_
5	like	like	IN	IN	_	6	case	_	_
6	cobalt	cobalt	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	nickel	nickel	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	mercury	mercury	NN	NN	_	6	conj	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	partially	partially	RB	RB	_	14	advmod	_	_
14	increase	increase	VBP	VBP	_	0	root	_	_
15	monokine	monokine	NN	NN	_	16	compound	_	_
16	secretion	secretion	NN	NN	_	14	dobj	_	_
17	but	but	CC	CC	_	14	cc	_	_
18	to	to	TO	TO	_	25	case	_	_
19	a	a	DT	DT	_	25	det	_	_
20	much	much	RB	RB	_	21	advmod	_	_
21	lower	lower	JJR	JJR	_	25	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	thus	thus	RB	RB	_	21	advmod	_	_
24	insignificant	insignificant	JJ	JJ	_	21	dep	_	_
25	extent	extent	NN	NN	_	14	conj	_	_
26	.	.	.	.	_	14	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	fail	fail	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	induce	induce	VB	VB	_	2	xcomp	_	_
5	mRNA	mrna	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	5	nmod	_	_
8	after	after	IN	IN	_	10	case	_	_
9	3	3	CD	CD	_	10	nummod	_	_
10	h	h	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	culture	culture	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	monokine	monokine	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	zinc-specific	zinc-specific	JJ	JJ	_	8	amod	_	_
8	effect	effect	NN	NN	_	0	root	_	_
9	influenced	influence	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	physicochemical	physicochemical	JJ	JJ	_	13	amod	_	_
13	properties	property	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	ion	ion	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Confirmation	confirmation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	unique	unique	JJ	JJ	_	5	amod	_	_
5	significance	significance	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	zinc	zinc	NN	NN	_	5	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	function	function	NN	NN	_	5	nmod	_	_
11	provides	provide	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	better	better	JJR	JJR	_	14	amod	_	_
14	understanding	understanding	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	mechanisms	mechanism	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	specific	specific	JJ	JJ	_	22	amod	_	_
20	zinc-mediated	zinc-mediated	JJ	JJ	_	22	amod	_	_
21	immune	immune	JJ	JJ	_	22	amod	_	_
22	modulation	modulation	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	expression	expression	NN	NN	_	2	conj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	cultured	culture	VBN	VBN	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	FOSB	fosb	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	2	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	G0S3	g0s3	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	2	punct	_	_

1	G0S3	g0s3	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	member	member	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	set	set	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	putative	putative	JJ	JJ	_	13	amod	_	_
10	G0/G1	g0/g1	NN	NN	_	13	compound	_	_
11	switch	switch	NN	NN	_	13	compound	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	7	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	G0S	g0s	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	selected	select	VBN	VBN	_	13	acl	_	_
19	by	by	IN	IN	_	20	mark	_	_
20	screening	screen	VBG	VBG	_	18	advcl	_	_
21	cDNA	cdna	NN	NN	_	22	compound	_	_
22	libraries	library	NNS	NNS	_	20	dobj	_	_
23	prepared	prepare	VBN	VBN	_	22	acl	_	_
24	from	from	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	blood	blood	NN	NN	_	28	compound	_	_
27	mononuclear	mononuclear	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	cultured	culture	VBN	VBN	_	28	acl	_	_
30	for	for	IN	IN	_	32	case	_	_
31	2	2	CD	CD	_	32	nummod	_	_
32	hr	hr	NN	NN	_	29	nmod	_	_
33	with	with	IN	IN	_	34	case	_	_
34	lectin	lectin	NN	NN	_	29	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	cycloheximide	cycloheximide	NN	NN	_	34	conj	_	_
37	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	homology	homology	NN	NN	_	3	dobj	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	murine	murine	JJ	JJ	_	10	amod	_	_
9	FOSB	fosb	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	encodes	encode	VBZ	VBZ	_	10	acl:relcl	_	_
14	a	a	DT	DT	_	15	det	_	_
15	component	component	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	AP1	ap1	NN	NN	_	20	compound	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	regulator	regulator	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Comparison	comparison	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cDNA	cdna	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	genomic	genomic	JJ	JJ	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	3	conj	_	_
7	reveals	reveal	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	4-exon	4-exon	JJ	JJ	_	10	amod	_	_
10	structure	structure	NN	NN	_	7	dobj	_	_
11	characteristic	characteristic	JJ	JJ	_	10	amod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	FOS	fos	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	genes	gene	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Freshly	freshly	RB	RB	_	2	advmod	_	_
2	isolated	isolate	VBN	VBN	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	FOSB/G0S3	fosb/g0s3	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	FOS/G0S7	fos/g0s7	NN	NN	_	8	conj	_	_
11	mRNAs	mrna	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	decline	decline	VBP	VBP	_	6	acl:relcl	_	_
15	rapidly	rapidly	RB	RB	_	14	advmod	_	_
16	during	during	IN	IN	_	17	case	_	_
17	incubation	incubation	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	culture	culture	NN	NN	_	20	compound	_	_
20	medium	medium	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinetics	kinetics	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	expression	expression	NN	NN	_	2	nmod	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	high	high	JJ	JJ	_	10	amod	_	_
9	initial	initial	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	caused	cause	VBN	VBN	_	5	ccomp	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	isolation	isolation	NN	NN	_	16	compound	_	_
16	procedure	procedure	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	do	do	VBP	VBP	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	reflect	reflect	VB	VB	_	5	conj	_	_
22	constitutive	constitutive	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	cells	cell	NNS	NNS	_	12	nmod	_	_
3	preincubated	preincubate	VBN	VBN	_	2	acl	_	_
4	for	for	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	day	day	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	levels	level	NNS	NNS	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	FOS	fos	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	8	nmod	_	_
12	reach	reach	VBP	VBP	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	maximum	maximum	NN	NN	_	12	dobj	_	_
15	20	20	CD	CD	_	16	nummod	_	_
16	min	min	NN	NN	_	12	nmod	_	_
17	after	after	IN	IN	_	16	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	addition	addition	NN	NN	_	16	dep	_	_
20	of	of	IN	IN	_	21	case	_	_
21	lectin	lectin	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	decline	decline	VBP	VBP	_	12	conj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	control	control	NN	NN	_	26	compound	_	_
26	levels	level	NNS	NNS	_	23	nmod	_	_
27	over	over	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	next	next	JJ	JJ	_	31	amod	_	_
30	3	3	CD	CD	_	31	nummod	_	_
31	hr	hr	NN	NN	_	23	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Levels	level	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	FOSB	fosb	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	1	nmod	_	_
5	reach	reach	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	maximum	maximum	JJ	JJ	_	5	dobj	_	_
8	40	40	CD	CD	_	9	nummod	_	_
9	min	min	NN	NN	_	5	nmod	_	_
10	after	after	IN	IN	_	9	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	addition	addition	NN	NN	_	9	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	lectin	lectin	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	decline	decline	VBP	VBP	_	5	conj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	control	control	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	16	nmod	_	_
20	over	over	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	next	next	JJ	JJ	_	24	amod	_	_
23	6	6	CD	CD	_	24	nummod	_	_
24	hr	hr	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	freshly	freshly	RB	RB	_	3	advmod	_	_
3	isolated	isolate	VBN	VBN	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	FOS	fo	NNS	NNS	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	FOSB	fosb	NN	NN	_	7	conj	_	_
10	mRNAs	mrna	NNS	NNS	_	11	nsubj	_	_
11	increase	increase	VBP	VBP	_	0	root	_	_
12	dramatically	dramatically	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	20	case	_	_
14	response	response	NN	NN	_	20	dep	_	_
15	to	to	TO	TO	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	protein	protein	NN	NN	_	20	compound	_	_
18	synthesis	synthesis	NN	NN	_	20	compound	_	_
19	inhibitor	inhibitor	NN	NN	_	20	compound	_	_
20	cycloheximide	cycloheximide	NN	NN	_	11	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	preincubated	preincubated	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cycloheximide	cycloheximide	NN	NN	_	7	compound	_	_
7	response	response	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	decreased	decrease	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	especially	especially	RB	RB	_	14	advmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	case	case	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	FOSB	fosb	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	differences	difference	NNS	NNS	_	9	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	expression	expression	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	FOS	fos	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	FOSB	fosb	NN	NN	_	6	conj	_	_
9	suggest	suggest	VBP	VBP	_	0	root	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	roles	role	NNS	NNS	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	regulation	regulation	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	9	punct	_	_

1	Regions	region	NNS	NNS	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	low	low	JJ	JJ	_	7	amod	_	_
4	base	base	NN	NN	_	5	nmod:npmod	_	_
5	order-dependent	order-dependent	JJ	JJ	_	7	amod	_	_
6	stem-loop	stem-loop	JJ	JJ	_	7	amod	_	_
7	potential	potential	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	region	region	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	gene	gene	NN	NN	_	10	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	defined	define	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	indicate	indicate	VBP	VBP	_	0	root	_	_
3	where	where	WRB	WRB	_	8	advmod	_	_
4	base	base	NN	NN	_	5	compound	_	_
5	order	order	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	adapted	adapt	VBN	VBN	_	2	advcl	_	_
9	for	for	IN	IN	_	10	case	_	_
10	purposes	purpose	NNS	NNS	_	8	nmod	_	_
11	other	other	JJ	JJ	_	14	case	_	_
12	than	than	IN	IN	_	14	case	_	_
13	stem-loop	stem-loop	JJ	JJ	_	14	amod	_	_
14	stability	stability	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	e.g.	e.g.	FW	FW	_	10	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	encoding	encode	VBG	VBG	_	16	dep	_	_
19	proteins	protein	NNS	NNS	_	18	dobj	_	_
20	or	or	CC	CC	_	18	cc	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	regulation	regulation	NN	NN	_	18	conj	_	_
23	)	)	-RRB-	-RRB-	_	16	punct	_	_
24	.	.	.	.	_	2	punct	_	_

1	Regions	region	NNS	NNS	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	low	low	JJ	JJ	_	4	amod	_	_
4	potential	potential	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	68.5-kb	68.5-kb	JJ	JJ	_	9	amod	_	_
8	genomic	genomic	JJ	JJ	_	9	amod	_	_
9	segment	segment	NN	NN	_	1	nmod	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	FOSB	fosb	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	10	dobj	_	_
14	suggest	suggest	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	the	the	DT	DT	_	17	det	_	_
17	potential	potential	NN	NN	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	help	help	VB	VB	_	14	ccomp	_	_
20	locate	locate	VB	VB	_	19	ccomp	_	_
21	genes	gene	NNS	NNS	_	20	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	uncharted	uncharted	JJ	JJ	_	25	amod	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	sequences	sequence	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	STAT1	stat1	NN	NN	_	2	compound	_	_
2	pathway	pathway	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	involved	involve	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	activation	activation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	caprine	caprine	JJ	JJ	_	13	amod	_	_
9	arthritis-encephalitis	arthritis-encephalitis	JJ	JJ	_	13	amod	_	_
10	virus	virus	NN	NN	_	13	compound	_	_
11	long	long	JJ	JJ	_	13	amod	_	_
12	terminal	terminal	JJ	JJ	_	13	amod	_	_
13	repeat	repeat	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	caprine	caprine	JJ	JJ	_	10	amod	_	_
3	arthritis-encephalitis	arthritis-encephalitis	JJ	JJ	_	10	amod	_	_
4	virus	virus	NN	NN	_	10	compound	_	_
5	(	(	-LRB-	-LRB-	_	10	punct	_	_
6	CAEV	caev	NN	NN	_	10	compound	_	_
7	)	)	-RRB-	-RRB-	_	10	punct	_	_
8	long	long	JJ	JJ	_	10	amod	_	_
9	terminal	terminal	JJ	JJ	_	10	amod	_	_
10	repeat	repeat	NN	NN	_	15	nsubjpass	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	LTR	ltr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	gamma	gamma	NN	NN	_	18	compound	_	_
18	interferon	interferon	NN	NN	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	in	in	IN	IN	_	24	case	_	_
23	promonocytic	promonocytic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	70-bp	70-bp	JJ	JJ	_	8	amod	_	_
8	element	element	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	necessary	necessary	JJ	JJ	_	4	ccomp	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	sufficient	sufficient	JJ	JJ	_	10	conj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	response	response	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	CAEV	caev	NN	NN	_	19	compound	_	_
19	LTR	ltr	NN	NN	_	15	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	this	this	DT	DT	_	22	det	_	_
22	cytokine	cytokine	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	At	at	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	5'	5'	JJ	JJ	_	4	amod	_	_
4	end	end	NN	NN	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	this	this	DT	DT	_	10	det	_	_
7	70-bp	70-bp	JJ	JJ	_	10	amod	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	10	compound	_	_
9	response	response	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	0	root	_	_
12	sequence	sequence	NN	NN	_	13	compound	_	_
13	similarity	similarity	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	gamma	gamma	NN	NN	_	18	compound	_	_
17	activated	activated	JJ	JJ	_	18	amod	_	_
18	site	site	NN	NN	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	GAS	gas	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	putative	putative	JJ	JJ	_	8	amod	_	_
7	GAS	gas	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	13	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CAEV	caev	NN	NN	_	12	compound	_	_
12	LTR	ltr	NN	NN	_	8	nmod	_	_
13	binds	bind	VBZ	VBZ	_	3	ccomp	_	_
14	specifically	specifically	RB	RB	_	18	advmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	13	nmod	_	_
19	induced	induce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	promonocytic	promonocytic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Substitution	substitution	NN	NN	_	2	compound	_	_
2	mutations	mutation	NNS	NNS	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	consensus	consensus	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	2	nmod	_	_
7	eliminate	eliminate	VBP	VBP	_	0	root	_	_
8	binding	binding	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	inducible	inducible	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GAS	gas	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	9	nsubj	_	_
4	from	from	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	70-bp	70-bp	JJ	JJ	_	7	amod	_	_
7	motif	motif	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	sufficient	sufficient	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	confer	confer	VB	VB	_	9	xcomp	_	_
12	responsiveness	responsiveness	NN	NN	_	11	dobj	_	_
13	to	to	TO	TO	_	14	case	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	12	nmod	_	_
15	using	use	VBG	VBG	_	11	xcomp	_	_
16	a	a	DT	DT	_	19	det	_	_
17	heterologous	heterologous	JJ	JJ	_	19	amod	_	_
18	minimal	minimal	JJ	JJ	_	17	dep	_	_
19	promoter	promoter	NN	NN	_	15	dobj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Consistent	consistent	JJ	JJ	_	14	advmod	_	_
2	with	with	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	data	datum	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	same	same	JJ	JJ	_	9	amod	_	_
9	mutations	mutation	NNS	NNS	_	14	nsubj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	GAS	gas	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	9	nmod	_	_
14	eliminate	eliminate	VBP	VBP	_	0	root	_	_
15	responsiveness	responsiveness	NN	NN	_	14	dobj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	context	context	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	both	both	CC	CC	_	26	cc:preconj	_	_
23	a	a	DT	DT	_	26	det	_	_
24	functional	functional	JJ	JJ	_	26	amod	_	_
25	CAEV	caev	NN	NN	_	26	compound	_	_
26	LTR	ltr	NN	NN	_	20	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	a	a	DT	DT	_	30	det	_	_
29	heterologous	heterologous	JJ	JJ	_	30	amod	_	_
30	promoter	promoter	NN	NN	_	26	conj	_	_
31	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	11	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	GAS	gas	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	present	present	JJ	JJ	_	0	root	_	_
12	from	from	IN	IN	_	14	case	_	_
13	5	5	CD	CD	_	14	nummod	_	_
14	min	min	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	14	14	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	11	nmod	_	_
18	after	after	IN	IN	_	19	case	_	_
19	stimulation	stimulation	NN	NN	_	11	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	Binding	binding	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	GAS	gas	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CAEV	caev	NN	NN	_	13	compound	_	_
13	LTR	ltr	NN	NN	_	1	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	inhibited	inhibit	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	antibody	antibody	NN	NN	_	15	nmod	_	_
18	directed	direct	VBN	VBN	_	17	acl	_	_
19	against	against	IN	IN	_	20	case	_	_
20	STAT1	stat1	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	p91/84	p91/84	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	15	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	GAS	gas	NN	NN	_	5	compound	_	_
5	sequence	sequence	NN	NN	_	11	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CAEV	caev	NN	NN	_	9	compound	_	_
9	LTR	ltr	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	essential	essential	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	response	response	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	IFN-gamma	ifn-gamma	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	a	a	DT	DT	_	20	det	_	_
19	STAT1-like	stat1-like	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	21	nsubj	_	_
21	binds	bind	VBZ	VBZ	_	11	conj	_	_
22	to	to	TO	TO	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	site	site	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	STAT-1	stat-1	NN	NN	_	4	compound	_	_
3	signaling	signaling	NN	NN	_	4	compound	_	_
4	pathway	pathway	NN	NN	_	5	nsubj	_	_
5	provides	provide	VBZ	VBZ	_	0	root	_	_
6	at	at	IN	IN	_	7	case	_	_
7	least	least	JJS	JJS	_	8	nmod:npmod	_	_
8	one	one	CD	CD	_	9	nummod	_	_
9	mechanism	mechanism	NN	NN	_	5	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CAEV	caev	NN	NN	_	15	compound	_	_
15	LTR	ltr	NN	NN	_	11	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	11	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	demonstration	demonstration	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	STAT	stat	NN	NN	_	14	compound	_	_
13	family	family	NN	NN	_	14	compound	_	_
14	member	member	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regulation	regulation	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	viral	viral	JJ	JJ	_	21	amod	_	_
21	promoter	promoter	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Signaling	signaling	NN	NN	_	0	root	_	_
2	via	via	IN	IN	_	3	case	_	_
3	IL-2	il-2	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-4	il-4	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	11	case	_	_
7	JAK3-deficient	jak3-deficient	JJ	JJ	_	11	amod	_	_
8	severe	severe	JJ	JJ	_	11	amod	_	_
9	combined	combined	JJ	JJ	_	11	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
12	:	:	:	:	_	1	punct	_	_
13	JAK3-dependent	jak3-dependent	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	independent	independent	JJ	JJ	_	13	conj	_	_
16	pathways	pathway	NNS	NNS	_	1	dep	_	_
17	.	.	.	.	_	1	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	IL-2	il-2	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IL-4	il-4	NN	NN	_	2	conj	_	_
5	bind	bind	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	receptors	receptor	NNS	NNS	_	5	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	common	common	JJ	JJ	_	12	amod	_	_
11	gamma	gamma	NN	NN	_	12	compound	_	_
12	chain	chain	NN	NN	_	8	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	JAK3	jak3	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	JAK3	jak3	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	26	advcl	_	_
5	for	for	IN	IN	_	8	case	_	_
6	proper	proper	JJ	JJ	_	8	amod	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	development	development	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	26	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	precise	precise	JJ	JJ	_	12	amod	_	_
12	roles	role	NNS	NNS	_	26	nsubjpass	_	_
13	of	of	IN	IN	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	kinase	kinase	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	IL-2	il-2	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-4	il-4	NN	NN	_	17	conj	_	_
20	signaling	signaling	NN	NN	_	12	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	20	nmod	_	_
23	have	have	VBP	VBP	_	26	aux	_	_
24	not	not	RB	RB	_	26	neg	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	defined	define	VBN	VBN	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	studied	study	VBN	VBN	_	0	root	_	_
6	IL-2	il-2	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-4	il-4	NN	NN	_	6	conj	_	_
9	signaling	signaling	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	9	nmod	_	_
14	lacking	lack	VBG	VBG	_	13	acl	_	_
15	JAK3	jak3	NN	NN	_	14	dobj	_	_
16	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	IL-2-induced	il-2-induced	JJ	JJ	_	3	amod	_	_
3	phosphorylation	phosphorylation	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	IL-2R	il-2r	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	JAK1	jak1	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	STAT5	stat5	NN	NN	_	6	conj	_	_
12	all	all	DT	DT	_	3	advmod	_	_
13	required	require	VBN	VBN	_	33	advcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	JAK3	jak3	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	33	punct	_	_
19	IL-4-mediated	il-4-mediated	JJ	JJ	_	20	amod	_	_
20	phosphorylation	phosphorylation	NN	NN	_	33	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	JAK1	jak1	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	STAT6	stat6	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	insulin	insulin	NN	NN	_	29	compound	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	substrates	substrate	NNS	NNS	_	22	conj	_	_
30	1	1	CD	CD	_	29	dep	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	2	2	CD	CD	_	30	conj	_	_
33	did	do	VBD	VBD	_	0	root	_	_
34	not	not	RB	RB	_	33	neg	_	_
35	.	.	.	.	_	33	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	IL-4-induced	il-4-induced	JJ	JJ	_	4	amod	_	_
4	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	clearly	clearly	RB	RB	_	7	advmod	_	_
7	improved	improve	VBN	VBN	_	0	root	_	_
8	following	follow	VBG	VBG	_	10	case	_	_
9	JAK3	jak3	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	7	nsubj	_	_
7	occurs	occur	VBZ	VBZ	_	3	ccomp	_	_
8	in	in	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	dep	_	_
10	absence	absence	NN	NN	_	13	dep	_	_
11	of	of	IN	IN	_	13	case	_	_
12	of	of	IN	IN	_	13	case	_	_
13	JAK3	jak3	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	but	but	CC	CC	_	7	cc	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	comparatively	comparatively	RB	RB	_	18	advmod	_	_
18	inefficient	inefficient	JJ	JJ	_	7	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	help	help	VB	VB	_	0	root	_	_
5	in	in	RP	RP	_	6	dep	_	_
6	understanding	understand	VBG	VBG	_	4	advcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	pathogenesis	pathogenesis	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	occurs	occur	VBZ	VBZ	_	11	acl:relcl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	mutations	mutation	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	JAK3	jak3	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	suggest	suggest	VB	VB	_	4	conj	_	_
21	a	a	DT	DT	_	22	det	_	_
22	mechanism	mechanism	NN	NN	_	20	dobj	_	_
23	for	for	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	pleiotropic	pleiotropic	JJ	JJ	_	26	amod	_	_
26	effects	effect	NNS	NNS	_	22	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-4	il-4	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Differentiation-dependent	differentiation-dependent	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	carboxylesterase	carboxylesterase	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	9	conj	_	_
13	binding	bind	VBG	VBG	_	12	acl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	promoter	promoter	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Carboxylesterases	carboxylesterase	NNS	NNS	_	2	nsubj	_	_
2	play	play	VBP	VBP	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	defense	defense	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	clearance	clearance	NN	NN	_	7	conj	_	_
10	mechanisms	mechanism	NNS	NNS	_	7	dep	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	monocyte/macrophage	monocyte/macrophage	NN	NN	_	14	compound	_	_
14	system	system	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	During	during	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	differentiation	differentiation	NN	NN	_	4	compound	_	_
4	process	process	NN	NN	_	14	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	cells	cell	NNS	NNS	_	4	nmod	_	_
7	from	from	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	line	line	NN	NN	_	12	compound	_	_
12	THP-1	thp-1	NN	NN	_	6	nmod	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	observed	observe	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	18	det	_	_
16	transient	transient	JJ	JJ	_	18	amod	_	_
17	transcriptional	transcriptional	JJ	JJ	_	16	dep	_	_
18	upregulation	upregulation	NN	NN	_	14	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	carboxylesterase	carboxylesterase	NN	NN	_	18	nmod	_	_
23	analyzed	analyze	VBN	VBN	_	18	acl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	means	means	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	Northern	northern	NN	NN	_	28	compound	_	_
28	blots	blot	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	PMA-treated	pma-treated	JJ	JJ	_	4	amod	_	_
3	THP-1	thp-1	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nmod	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	detect	detect	VB	VB	_	0	root	_	_
8	three	three	CD	CD	_	12	nummod	_	_
9	major	major	JJ	JJ	_	12	amod	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	initiation	initiation	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	7	dobj	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	revealed	reveal	VBN	VBN	_	7	advcl	_	_
15	by	by	IN	IN	_	18	case	_	_
16	Nuclease	nuclease	NN	NN	_	18	compound	_	_
17	Protection	protection	NN	NN	_	18	compound	_	_
18	Assay	assay	NN	NN	_	14	nmod	_	_
19	carried	carry	VBN	VBN	_	18	acl	_	_
20	out	out	IN	IN	_	19	compound:prt	_	_
21	with	with	IN	IN	_	26	case	_	_
22	two	two	CD	CD	_	26	nummod	_	_
23	overlapping	overlap	VBG	VBG	_	26	amod	_	_
24	antisense	antisense	JJ	JJ	_	26	amod	_	_
25	RNA	rna	NN	NN	_	26	compound	_	_
26	probes	probe	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	cloned	clone	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	carboxylesterase	carboxylesterase	NN	NN	_	8	compound	_	_
7	upstream	upstream	JJ	JJ	_	8	amod	_	_
8	sequence	sequence	NN	NN	_	4	dobj	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	showed	show	VBN	VBN	_	4	conj	_	_
11	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
12	basal	basal	JJ	JJ	_	13	amod	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	CHO	cho	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	1	dobj	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	1	parataxis	_	_
8	that	that	IN	IN	_	30	mark	_	_
9	the	the	DT	DT	_	11	det	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	30	nsubjpass	_	_
12	spanning	span	VBG	VBG	_	11	acl	_	_
13	base	base	NN	NN	_	14	compound	_	_
14	pairs	pair	NNS	NNS	_	12	dobj	_	_
15	-1	-1	CD	CD	_	14	nummod	_	_
16	to	to	TO	TO	_	14	dep	_	_
17	-275	-275	CD	CD	_	14	nummod	_	_
18	,	,	,	,	_	11	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	contains	contain	VBZ	VBZ	_	11	acl:relcl	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	putative	putative	JJ	JJ	_	24	amod	_	_
23	binding	bind	VBG	VBG	_	24	amod	_	_
24	sites	site	NNS	NNS	_	20	dobj	_	_
25	for	for	IN	IN	_	27	case	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	11	punct	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	bound	bind	VBN	VBN	_	7	ccomp	_	_
31	by	by	IN	IN	_	33	case	_	_
32	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
33	factors	factor	NNS	NNS	_	30	nmod	_	_
34	Sp1	sp1	NN	NN	_	33	dep	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	IRBP	irbp	NN	NN	_	34	conj	_	_
37	but	but	CC	CC	_	33	cc	_	_
38	not	not	RB	RB	_	40	neg	_	_
39	by	by	IN	IN	_	40	case	_	_
40	C/EBPs	c/ebps	NNS	NNS	_	33	conj	_	_
41	.	.	.	.	_	1	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	1	parataxis	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	carboxylesterase	carboxylesterase	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	13	nsubj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	THP-1	thp-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	starts	start	VBZ	VBZ	_	5	ccomp	_	_
14	at	at	IN	IN	_	17	case	_	_
15	multiple	multiple	JJ	JJ	_	17	amod	_	_
16	initiation	initiation	NN	NN	_	17	compound	_	_
17	sites	site	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	that	that	IN	IN	_	26	mark	_	_
20	Sp1	sp1	NN	NN	_	26	nsubj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	IRBP	irbp	NN	NN	_	20	conj	_	_
23	may	may	MD	MD	_	26	aux	_	_
24	be	be	VB	VB	_	26	cop	_	_
25	critical	critical	JJ	JJ	_	26	amod	_	_
26	factors	factor	NNS	NNS	_	13	conj	_	_
27	for	for	IN	IN	_	28	mark	_	_
28	modulating	modulate	VBG	VBG	_	26	acl	_	_
29	the	the	DT	DT	_	31	det	_	_
30	differentiation-dependent	differentiation-dependent	JJ	JJ	_	31	amod	_	_
31	transcription	transcription	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	36	case	_	_
33	this	this	DT	DT	_	36	det	_	_
34	human	human	JJ	JJ	_	36	amod	_	_
35	carboxylesterase	carboxylesterase	NN	NN	_	36	compound	_	_
36	gene	gene	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	1	punct	_	_

1	Glycation-dependent	glycation-dependent	JJ	JJ	_	6	amod	_	_
2	,	,	,	,	_	1	punct	_	_
3	reactive	reactive	JJ	JJ	_	5	amod	_	_
4	oxygen	oxygen	NN	NN	_	5	nmod:npmod	_	_
5	species-mediated	species-mediated	JJ	JJ	_	1	dep	_	_
6	suppression	suppression	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	insulin	insulin	NN	NN	_	12	compound	_	_
10	gene	gene	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	HIT	hit	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Prolonged	prolonged	JJ	JJ	_	4	amod	_	_
2	poor	poor	JJ	JJ	_	1	dep	_	_
3	glycemic	glycemic	JJ	JJ	_	1	dep	_	_
4	control	control	NN	NN	_	11	nsubj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	non-insulin-dependent	non-insulin-dependent	JJ	JJ	_	9	amod	_	_
7	diabetes	diabetes	NN	NN	_	9	compound	_	_
8	mellitus	mellitus	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	4	nmod	_	_
10	often	often	RB	RB	_	11	advmod	_	_
11	leads	lead	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	decline	decline	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	insulin	insulin	NN	NN	_	17	compound	_	_
17	secretion	secretion	NN	NN	_	14	nmod	_	_
18	from	from	IN	IN	_	21	case	_	_
19	pancreatic	pancreatic	JJ	JJ	_	21	amod	_	_
20	beta	beta	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	14	punct	_	_
23	accompanied	accompany	VBN	VBN	_	14	acl	_	_
24	by	by	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	decrease	decrease	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	insulin	insulin	NN	NN	_	30	compound	_	_
30	content	content	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	11	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	step	step	NN	NN	_	20	nmod	_	_
4	toward	toward	IN	IN	_	5	mark	_	_
5	elucidating	elucidate	VBG	VBG	_	3	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	pathophysiological	pathophysiological	JJ	JJ	_	8	amod	_	_
8	background	background	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	so-called	so-called	JJ	JJ	_	13	amod	_	_
12	glucose	glucose	NN	NN	_	13	compound	_	_
13	toxicity	toxicity	NN	NN	_	8	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	pancreatic	pancreatic	JJ	JJ	_	17	amod	_	_
16	beta	beta	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	induced	induce	VBD	VBD	_	0	root	_	_
21	glycation	glycation	NN	NN	_	20	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	HIT-T15	hit-t15	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	using	use	VBG	VBG	_	20	xcomp	_	_
26	a	a	DT	DT	_	27	det	_	_
27	sugar	sugar	NN	NN	_	25	dobj	_	_
28	with	with	IN	IN	_	31	case	_	_
29	strong	strong	JJ	JJ	_	31	amod	_	_
30	deoxidizing	deoxidizing	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	27	punct	_	_
33	D-ribose	d-ribose	NN	NN	_	27	appos	_	_
34	,	,	,	,	_	20	punct	_	_
35	and	and	CC	CC	_	20	cc	_	_
36	examined	examine	VBD	VBD	_	20	conj	_	_
37	the	the	DT	DT	_	38	det	_	_
38	effects	effect	NNS	NNS	_	36	dobj	_	_
39	on	on	IN	IN	_	42	case	_	_
40	insulin	insulin	NN	NN	_	42	compound	_	_
41	gene	gene	NN	NN	_	42	compound	_	_
42	transcription	transcription	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	analyses	analysis	NNS	NNS	_	2	nmod	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	15	mark	_	_
9	the	the	DT	DT	_	12	det	_	_
10	insulin	insulin	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	sensitive	sensitive	JJ	JJ	_	7	ccomp	_	_
16	to	to	TO	TO	_	17	case	_	_
17	glycation	glycation	NN	NN	_	15	nmod	_	_
18	than	than	IN	IN	_	23	mark	_	_
19	the	the	DT	DT	_	23	det	_	_
20	control	control	JJ	JJ	_	23	amod	_	_
21	beta-actin	beta-actin	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	15	ccomp	_	_
24	;	;	:	:	_	7	punct	_	_
25	approximately	approximately	RB	RB	_	26	advmod	_	_
26	50	50	CD	CD	_	29	nummod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	80	80	CD	CD	_	26	conj	_	_
29	%	%	NN	NN	_	37	nsubjpass	_	_
30	of	of	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	insulin	insulin	NN	NN	_	34	compound	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	29	nmod	_	_
36	was	be	VBD	VBD	_	37	auxpass	_	_
37	lost	lose	VBN	VBN	_	7	parataxis	_	_
38	when	when	WRB	WRB	_	42	advmod	_	_
39	the	the	DT	DT	_	40	det	_	_
40	cells	cell	NNS	NNS	_	42	nsubjpass	_	_
41	were	be	VBD	VBD	_	42	auxpass	_	_
42	kept	keep	VBN	VBN	_	37	advcl	_	_
43	for	for	IN	IN	_	45	case	_	_
44	3	3	CD	CD	_	45	nummod	_	_
45	d	d	NN	NN	_	42	nmod	_	_
46	in	in	IN	IN	_	48	case	_	_
47	the	the	DT	DT	_	48	det	_	_
48	presence	presence	NN	NN	_	42	nmod	_	_
49	of	of	IN	IN	_	54	case	_	_
50	40	40	CD	CD	_	53	dep	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	60	60	CD	CD	_	50	conj	_	_
53	mM	mm	NN	NN	_	54	dep	_	_
54	D-ribose	d-ribose	NN	NN	_	48	nmod	_	_
55	,	,	,	,	_	42	punct	_	_
56	respectively	respectively	RB	RB	_	42	advmod	_	_
57	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	agreement	agreement	NN	NN	_	15	nmod	_	_
3	with	with	IN	IN	_	4	case	_	_
4	this	this	DT	DT	_	2	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	decrease	decrease	NN	NN	_	15	nsubjpass	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	dep	_	_
9	insulin	insulin	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	insulin	insulin	NN	NN	_	13	compound	_	_
13	content	content	NN	NN	_	10	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	observed	observe	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	glycation-induced	glycation-induced	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Also	also	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	gel	gel	NN	NN	_	6	compound	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	analyses	analysis	NNS	NNS	_	10	nsubj	_	_
7	using	use	VBG	VBG	_	6	acl	_	_
8	specific	specific	JJ	JJ	_	9	amod	_	_
9	antiserum	antiserum	NN	NN	_	7	dobj	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	decrease	decrease	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	DNA-binding	dna-binding	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	an	a	DT	DT	_	21	det	_	_
18	insulin	insulin	NN	NN	_	21	compound	_	_
19	gene	gene	NN	NN	_	21	compound	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	15	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	PDX-1/IPF1/STF-1	pdx-1/ipf1/stf-1	NN	NN	_	21	appos	_	_
24	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	D-ribose	d-ribose	NN	NN	_	2	nmod	_	_
5	seemed	seem	VBD	VBD	_	0	root	_	_
6	almost	almost	RB	RB	_	7	advmod	_	_
7	irreversible	irreversible	JJ	JJ	_	5	xcomp	_	_
8	but	but	CC	CC	_	5	cc	_	_
9	could	could	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	prevented	prevent	VBN	VBN	_	5	conj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	addition	addition	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	1	1	CD	CD	_	16	compound	_	_
16	mM	mm	NN	NN	_	17	amod	_	_
17	aminoguanidine	aminoguanidine	NN	NN	_	13	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	10	10	CD	CD	_	20	compound	_	_
20	mM	mm	NN	NN	_	21	amod	_	_
21	N-acetylcysteine	n-acetylcysteine	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	5	punct	_	_
23	thus	thus	RB	RB	_	24	advmod	_	_
24	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
25	that	that	IN	IN	_	38	mark	_	_
26	glycation	glycation	NN	NN	_	38	nsubj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	reactive	reactive	JJ	JJ	_	30	amod	_	_
29	oxygen	oxygen	NN	NN	_	30	compound	_	_
30	species	species	NNS	NNS	_	26	conj	_	_
31	,	,	,	,	_	30	punct	_	_
32	generated	generate	VBN	VBN	_	30	acl	_	_
33	through	through	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	glycation	glycation	NN	NN	_	36	compound	_	_
36	reaction	reaction	NN	NN	_	32	nmod	_	_
37	,	,	,	,	_	26	punct	_	_
38	serve	serve	VBP	VBP	_	24	ccomp	_	_
39	as	as	IN	IN	_	40	case	_	_
40	mediators	mediator	NNS	NNS	_	38	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	phenomena	phenomenon	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	glycation	glycation	NN	NN	_	20	nsubj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	pancreatic	pancreatic	JJ	JJ	_	10	amod	_	_
9	beta	beta	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	occurs	occur	VBZ	VBZ	_	6	acl:relcl	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	13	advmod	_	_
16	under	under	IN	IN	_	18	case	_	_
17	chronic	chronic	JJ	JJ	_	18	amod	_	_
18	hyperglycemia	hyperglycemia	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	suppresses	suppress	VBZ	VBZ	_	3	ccomp	_	_
21	insulin	insulin	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	thus	thus	RB	RB	_	27	advmod	_	_
26	can	can	MD	MD	_	27	aux	_	_
27	explain	explain	VB	VB	_	20	conj	_	_
28	part	part	NN	NN	_	27	dobj	_	_
29	of	of	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	beta	beta	NN	NN	_	34	compound	_	_
32	cell	cell	NN	NN	_	34	compound	_	_
33	glucose	glucose	NN	NN	_	34	compound	_	_
34	toxicity	toxicity	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	5	nsubj	_	_
5	regulates	regulate	VBZ	VBZ	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	vacuolar	vacuolar	JJ	JJ	_	12	amod	_	_
10	H+-ATPase	h+-atpase	NN	NN	_	12	compound	_	_
11	B2	b2	NN	NN	_	12	compound	_	_
12	subunit	subunit	NN	NN	_	6	nmod	_	_
13	through	through	IN	IN	_	15	case	_	_
14	AP-2	ap-2	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	5	nmod	_	_
16	during	during	IN	IN	_	18	case	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	5	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	monocyte-to-macrophage	monocyte-to-macrophage	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	content	content	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	vacuolar	vacuolar	JJ	JJ	_	10	amod	_	_
10	H+-ATPase	h+-atpase	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	V-ATPase	v-atpase	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	increases	increase	VBZ	VBZ	_	0	root	_	_
15	more	more	RBR	RBR	_	17	advmod	_	_
16	than	than	IN	IN	_	17	amod	_	_
17	4-fold	4-fold	RB	RB	_	14	dobj	_	_
18	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	previously	previously	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	amplified	amplify	VBN	VBN	_	7	amod	_	_
7	expression	expression	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	B2	b2	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	V-ATPase	v-atpase	NN	NN	_	11	nmod	_	_
15	occurs	occur	VBZ	VBZ	_	3	ccomp	_	_
16	solely	solely	RB	RB	_	19	advmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	increased	increase	VBN	VBN	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	that	that	IN	IN	_	45	mark	_	_
23	the	the	DT	DT	_	25	det	_	_
24	5'-untranslated	5'-untranslated	JJ	JJ	_	25	amod	_	_
25	region	region	NN	NN	_	45	nsubjpass	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	B2	b2	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	25	punct	_	_
31	containing	contain	VBG	VBG	_	25	acl	_	_
32	multiple	multiple	JJ	JJ	_	35	amod	_	_
33	consensus	consensus	NN	NN	_	35	compound	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	sites	site	NNS	NNS	_	31	dobj	_	_
36	for	for	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	transcription	transcription	NN	NN	_	39	compound	_	_
39	factors	factor	NNS	NNS	_	35	nmod	_	_
40	AP-2	ap-2	NN	NN	_	39	dep	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	Sp1	sp1	NN	NN	_	40	conj	_	_
43	,	,	,	,	_	25	punct	_	_
44	is	be	VBZ	VBZ	_	45	auxpass	_	_
45	required	require	VBN	VBN	_	15	conj	_	_
46	for	for	IN	IN	_	48	case	_	_
47	this	this	DT	DT	_	48	det	_	_
48	expression	expression	NN	NN	_	45	nmod	_	_
49	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	AP-2	ap-2	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sequences	sequence	NNS	NNS	_	10	nsubj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	essential	essential	JJ	JJ	_	4	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	10	nmod	_	_
14	from	from	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	B2	b2	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	during	during	IN	IN	_	20	case	_	_
19	monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	13	nmod	_	_
21	and	and	CC	CC	_	10	cc	_	_
22	that	that	IN	IN	_	33	mark	_	_
23	AP-2	ap-2	NN	NN	_	33	nsubj	_	_
24	,	,	,	,	_	23	punct	_	_
25	expressed	express	VBN	VBN	_	23	acl	_	_
26	exogenously	exogenously	RB	RB	_	25	advmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	THP-1	thp-1	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	other	other	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	conj	_	_
32	,	,	,	,	_	23	punct	_	_
33	activates	activate	VBZ	VBZ	_	10	conj	_	_
34	transcription	transcription	NN	NN	_	33	dobj	_	_
35	from	from	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	B2	b2	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	15	nsubjpass	_	_
9	from	from	IN	IN	_	10	case	_	_
10	THP-1	thp-1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	U-937	u-937	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	identified	identify	VBN	VBN	_	0	root	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	binds	bind	VBZ	VBZ	_	15	dep	_	_
18	to	to	TO	TO	_	22	case	_	_
19	several	several	JJ	JJ	_	22	amod	_	_
20	AP-2	ap-2	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	elements	element	NNS	NNS	_	17	nmod	_	_
23	within	within	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	B2	b2	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	but	but	CC	CC	_	17	cc	_	_
29	does	do	VBZ	VBZ	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	react	react	VB	VB	_	17	conj	_	_
32	with	with	IN	IN	_	34	case	_	_
33	AP-2	ap-2	NN	NN	_	34	compound	_	_
34	antibodies	antibody	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	17	punct	_	_
36	and	and	CC	CC	_	17	cc	_	_
37	has	have	VBZ	VBZ	_	17	conj	_	_
38	a	a	DT	DT	_	43	det	_	_
39	DNA	dna	NN	NN	_	40	compound	_	_
40	sequence	sequence	NN	NN	_	43	compound	_	_
41	binding	binding	NN	NN	_	43	compound	_	_
42	affinity	affinity	NN	NN	_	43	compound	_	_
43	profile	profile	NN	NN	_	37	dobj	_	_
44	that	that	WDT	WDT	_	45	nsubj	_	_
45	differs	differ	VBZ	VBZ	_	43	acl:relcl	_	_
46	from	from	IN	IN	_	47	case	_	_
47	AP-2	ap-2	NN	NN	_	45	nmod	_	_
48	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	a	a	DT	DT	_	9	det	_	_
6	novel	novel	JJ	JJ	_	9	amod	_	_
7	AP-2-like	ap-2-like	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	16	case	_	_
13	V-ATPase	v-atpase	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	subunit	subunit	NN	NN	_	16	compound	_	_
16	amplification	amplification	NN	NN	_	11	nmod	_	_
17	during	during	IN	IN	_	19	case	_	_
18	monocyte	monocyte	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Bcd	bcd	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	proto-oncogene	proto-oncogene	NN	NN	_	3	appos	_	_
8	expressed	express	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	B-cells	b-cell	NNS	NNS	_	8	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	8	det	_	_
2	novel	novel	JJ	JJ	_	8	amod	_	_
3	B-cell	b-cell	NN	NN	_	4	nmod:npmod	_	_
4	derived	derived	JJ	JJ	_	8	amod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Bcd	bcd	NN	NN	_	4	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	oncogene	oncogene	NN	NN	_	11	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	isolated	isolate	VBN	VBN	_	0	root	_	_
12	from	from	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
15	blood	blood	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
17	of	of	IN	IN	_	26	case	_	_
18	one	one	CD	CD	_	26	nummod	_	_
19	B-cell	b-cell	NN	NN	_	22	compound	_	_
20	chronic	chronic	JJ	JJ	_	22	amod	_	_
21	lymphocytic	lymphocytic	JJ	JJ	_	22	amod	_	_
22	leukemia	leukemia	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	B-CLL	b-cll	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	patient	patient	NN	NN	_	16	nmod	_	_
27	using	use	VBG	VBG	_	11	xcomp	_	_
28	DNA	dna	NN	NN	_	29	compound	_	_
29	transfer	transfer	NN	NN	_	27	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	a	a	DT	DT	_	34	det	_	_
32	mouse	mouse	NN	NN	_	34	compound	_	_
33	tumorigenicity	tumorigenicity	NN	NN	_	34	compound	_	_
34	assay	assay	NN	NN	_	29	conj	_	_
35	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Bcd	bcd	NN	NN	_	3	compound	_	_
3	proto-oncogene	proto-oncogene	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	activated	activate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	truncation	truncation	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	5'	5'	JJ	JJ	_	12	amod	_	_
12	UTR	utr	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	predicts	predict	VBZ	VBZ	_	0	root	_	_
3	for	for	IN	IN	_	7	case	_	_
4	two	two	CD	CD	_	7	nummod	_	_
5	open	open	JJ	JJ	_	7	amod	_	_
6	reading	reading	NN	NN	_	7	compound	_	_
7	frames	frame	NNS	NNS	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	ORFs	orf	NNS	NNS	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	.	.	.	.	_	2	punct	_	_

1	ORF1	orf1	NN	NN	_	2	nsubj	_	_
2	consists	consist	VBZ	VBZ	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	240	240	CD	CD	_	5	nummod	_	_
5	bp	bp	NN	NN	_	2	nmod	_	_
6	that	that	WDT	WDT	_	8	nsubj	_	_
7	would	would	MD	MD	_	8	aux	_	_
8	encode	encode	VB	VB	_	5	acl:relcl	_	_
9	80	80	CD	CD	_	11	nummod	_	_
10	amino	amino	NN	NN	_	11	compound	_	_
11	acids	acid	NNS	NNS	_	8	dobj	_	_
12	,	,	,	,	_	2	punct	_	_
13	while	while	IN	IN	_	17	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	major	major	JJ	JJ	_	16	amod	_	_
16	ORF2	orf2	NN	NN	_	17	nsubj	_	_
17	consists	consist	VBZ	VBZ	_	2	advcl	_	_
18	of	of	IN	IN	_	20	case	_	_
19	648	648	CD	CD	_	20	nummod	_	_
20	bp	bp	NN	NN	_	17	nmod	_	_
21	capable	capable	JJ	JJ	_	20	amod	_	_
22	of	of	IN	IN	_	23	mark	_	_
23	coding	code	VBG	VBG	_	21	advcl	_	_
24	for	for	IN	IN	_	27	case	_	_
25	216	216	CD	CD	_	27	nummod	_	_
26	amino	amino	NN	NN	_	27	compound	_	_
27	acids	acid	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Predicted	predict	VBN	VBN	_	3	amod	_	_
2	peptide	peptide	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	ORF2	orf2	NN	NN	_	3	nmod	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	zinc	zinc	NN	NN	_	10	compound	_	_
9	finger	finger	NN	NN	_	10	compound	_	_
10	domain	domain	NN	NN	_	6	dobj	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	showed	show	VBD	VBD	_	10	acl:relcl	_	_
13	significant	significant	JJ	JJ	_	14	amod	_	_
14	homology	homology	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	19	case	_	_
16	GC	gc	NN	NN	_	19	compound	_	_
17	box	box	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	14	nmod	_	_
20	BTEB2	bteb2	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	SP1	sp1	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Transfection	transfection	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	an	a	DT	DT	_	5	det	_	_
4	expression	expression	NN	NN	_	5	compound	_	_
5	vector	vector	NN	NN	_	1	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	ORF2	orf2	NN	NN	_	6	dobj	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	7	cc	_	_
10	full	full	JJ	JJ	_	12	amod	_	_
11	length	length	NN	NN	_	12	compound	_	_
12	cDNA	cdna	NN	NN	_	7	conj	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	able	able	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	transform	transform	VB	VB	_	14	xcomp	_	_
17	NIH3T3	nih3t3	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	16	dobj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	induce	induce	VB	VB	_	16	conj	_	_
21	tumors	tumor	NNS	NNS	_	20	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	nude	nude	JJ	JJ	_	24	amod	_	_
24	mice	mouse	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Bcd	bcd	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	transcripts	transcript	NNS	NNS	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	&lt;	&lt;	JJR	JJR	_	9	amod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	=	=	JJ	JJ	_	5	conj	_	_
8	2.6	2.6	CD	CD	_	9	nummod	_	_
9	kb	kb	NN	NN	_	3	nmod	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	selectively	selectively	RB	RB	_	12	advmod	_	_
12	expressed	express	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	PBL	pbl	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	testis	testis	NN	NN	_	14	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	healthy	healthy	JJ	JJ	_	19	amod	_	_
19	individuals	individual	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	PBL	pbl	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	Bcd	bcd	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	restricted	restricted	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	CD19+	cd19+	JJ	JJ	_	12	amod	_	_
12	B-cells	b-cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	absent	absent	JJ	JJ	_	9	conj	_	_
15	from	from	IN	IN	_	17	case	_	_
16	CD14+	cd14+	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	T-cells	t-cell	NNS	NNS	_	17	conj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Bcd	bcd	NN	NN	_	2	compound	_	_
2	transcripts	transcript	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	all	all	DT	DT	_	9	det	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	PBL	pbl	NN	NN	_	9	compound	_	_
9	samples	sample	NNS	NNS	_	4	nmod	_	_
10	tested	test	VBN	VBN	_	9	acl	_	_
11	but	but	CC	CC	_	9	cc	_	_
12	not	not	RB	RB	_	18	neg	_	_
13	in	in	IN	IN	_	18	case	_	_
14	several	several	JJ	JJ	_	18	amod	_	_
15	malignant	malignant	JJ	JJ	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	B-cell	b-cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	9	conj	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	in	in	IN	IN	_	23	case	_	_
22	50	50	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	9	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	B-cells	b-cell	NNS	NNS	_	23	nmod	_	_
26	from	from	IN	IN	_	28	case	_	_
27	B-CLL	b-cll	NN	NN	_	28	compound	_	_
28	patients	patient	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	stimulation	stimulation	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	B-cells	b-cell	NNS	NNS	_	3	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	B-CLL	b-cll	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	under	under	IN	IN	_	10	case	_	_
10	conditions	condition	NNS	NNS	_	3	nmod	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	induced	induce	VBD	VBD	_	10	acl:relcl	_	_
13	differentiation	differentiation	NN	NN	_	12	dobj	_	_
14	into	into	IN	IN	_	16	case	_	_
15	plasma	plasma	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	associated	associate	VBN	VBN	_	0	root	_	_
19	with	with	IN	IN	_	20	case	_	_
20	induction	induction	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	Bcd	bcd	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Bcd	bcd	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	6	nsubj	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	therefore	therefore	RB	RB	_	6	advmod	_	_
6	play	play	VB	VB	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	B-cell	b-cell	NN	NN	_	6	nmod	_	_
12	growth	growth	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	development	development	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	6	punct	_	_

1	GATA-1	gata-1	NN	NN	_	4	compound	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	late	late	JJ	JJ	_	10	amod	_	_
9	S	s	NN	NN	_	10	compound	_	_
10	phase	phase	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	erythroid	erythroid	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	set	set	VBN	VBN	_	0	root	_	_
4	out	out	RP	RP	_	3	compound:prt	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	test	test	VB	VB	_	3	xcomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	model	model	NN	NN	_	6	dobj	_	_
9	for	for	IN	IN	_	12	case	_	_
10	tissue-specific	tissue-specific	JJ	JJ	_	12	amod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	relies	rely	VBZ	VBZ	_	8	acl:relcl	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	early	early	JJ	JJ	_	18	amod	_	_
18	replication	replication	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	expressed	express	VBN	VBN	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	sequester	sequester	VB	VB	_	14	xcomp	_	_
24	limiting	limit	VBG	VBG	_	27	amod	_	_
25	activating	activate	VBG	VBG	_	27	amod	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	23	dobj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	an	a	DT	DT	_	5	det	_	_
3	erythroid	erythroid	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	tested	test	VBN	VBN	_	1	parataxis	_	_
10	the	the	DT	DT	_	11	det	_	_
11	changes	change	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	lineage-restricted	lineage-restricted	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	16	nmod	_	_
22	GATA-1	gata-1	NN	NN	_	21	dep	_	_
23	through	through	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	cycle	cycle	NN	NN	_	11	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	GATA-1	gata-1	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	low	low	JJ	JJ	_	2	ccomp	_	_
8	in	in	IN	IN	_	9	case	_	_
9	G1	g1	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	peaks	peak	VBZ	VBZ	_	7	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	mid-S	mid-s	NN	NN	_	14	compound	_	_
14	phase	phase	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	then	then	RB	RB	_	18	advmod	_	_
18	decreases	decrease	VBZ	VBZ	_	7	conj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	G2/M	g2/m	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activities	activity	NNS	NNS	_	17	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	ubiquitous	ubiquitous	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	Oct1	oct1	NN	NN	_	11	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Sp1	sp1	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	6	punct	_	_
17	remain	remain	VBP	VBP	_	0	root	_	_
18	high	high	JJ	JJ	_	17	xcomp	_	_
19	in	in	IN	IN	_	20	case	_	_
20	G2/M	g2/m	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	GATA-1	gata-1	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mRNA	mrna	NN	NN	_	2	conj	_	_
5	vary	vary	VBP	VBP	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	similar	similar	JJ	JJ	_	9	amod	_	_
9	manner	manner	NN	NN	_	5	nmod	_	_
10	through	through	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	cycle	cycle	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	suggesting	suggest	VBG	VBG	_	5	xcomp	_	_
16	that	that	IN	IN	_	29	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	29	nsubjpass	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	gene	gene	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	18	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	stability	stability	NN	NN	_	18	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	message	message	NN	NN	_	24	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	regulated	regulate	VBN	VBN	_	15	ccomp	_	_
30	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	20	mark	_	_
2	a	a	DT	DT	_	3	det	_	_
3	number	number	NN	NN	_	20	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	control	control	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	cycle	cycle	NN	NN	_	10	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	replication	replication	NN	NN	_	14	conj	_	_
18	have	have	VBP	VBP	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	shown	show	VBN	VBN	_	31	advcl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	peak	peak	VB	VB	_	20	xcomp	_	_
23	in	in	IN	IN	_	25	case	_	_
24	S	s	NN	NN	_	25	compound	_	_
25	phase	phase	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	31	punct	_	_
27	this	this	DT	DT	_	31	nsubj	_	_
28	is	be	VBZ	VBZ	_	31	cop	_	_
29	the	the	DT	DT	_	31	det	_	_
30	first	first	JJ	JJ	_	31	amod	_	_
31	example	example	NN	NN	_	0	root	_	_
32	of	of	IN	IN	_	36	case	_	_
33	a	a	DT	DT	_	36	det	_	_
34	lineage-restricted	lineage-restricted	JJ	JJ	_	36	amod	_	_
35	transcription	transcription	NN	NN	_	36	compound	_	_
36	factor	factor	NN	NN	_	31	nmod	_	_
37	displaying	display	VBG	VBG	_	36	acl	_	_
38	S	s	NN	NN	_	42	compound	_	_
39	phase-specific	phase-specific	JJ	JJ	_	42	amod	_	_
40	DNA	dna	NN	NN	_	42	compound	_	_
41	binding	binding	NN	NN	_	42	compound	_	_
42	activity	activity	NN	NN	_	37	dobj	_	_
43	.	.	.	.	_	31	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	interpretation	interpretation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	2	nmod	_	_
6	leads	lead	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	model	model	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	18	nmod	_	_
12	the	the	DT	DT	_	13	det	_	_
13	peak	peak	NN	NN	_	18	nsubj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	GATA-1	gata-1	NN	NN	_	17	compound	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	binding	binding	NN	NN	_	13	nmod	_	_
18	amplifies	amplify	VBZ	VBZ	_	9	acl:relcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	early	early	JJ	JJ	_	23	amod	_	_
23	replication	replication	NN	NN	_	20	nmod	_	_
24	on	on	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activation	activation	NN	NN	_	20	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	erythroid-specific	erythroid-specific	JJ	JJ	_	29	amod	_	_
29	genes	gene	NNS	NNS	_	26	nmod	_	_
30	at	at	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	same	same	JJ	JJ	_	33	amod	_	_
33	time	time	NN	NN	_	20	nmod	_	_
34	as	as	IN	IN	_	36	case	_	_
35	preventing	prevent	VBG	VBG	_	36	amod	_	_
36	activation	activation	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	non-erythroid	non-erythroid	JJ	JJ	_	39	amod	_	_
39	genes	gene	NNS	NNS	_	36	nmod	_	_
40	containing	contain	VBG	VBG	_	39	acl	_	_
41	GATA-responsive	gata-responsive	JJ	JJ	_	42	amod	_	_
42	elements	element	NNS	NNS	_	40	dobj	_	_
43	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	may	may	MD	MD	_	5	aux	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	relate	relate	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	recent	recent	JJ	JJ	_	8	amod	_	_
8	data	datum	NNS	NNS	_	5	nmod	_	_
9	implicating	implicate	VBG	VBG	_	8	acl	_	_
10	GATA-1	gata-1	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	apoptosis	apoptosis	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	cycle	cycle	NN	NN	_	17	compound	_	_
17	progression	progression	NN	NN	_	13	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	dephosphorylation	dephosphorylation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activation	activation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	member	member	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	of	of	IN	IN	_	15	amod	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	NF-AT1	nf-at1	NN	NN	_	15	appos	_	_
18	,	,	,	,	_	2	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	Tax-expressing	tax-expressing	JJ	JJ	_	2	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	type	type	NN	NN	_	26	compound	_	_
23	I	i	CD	CD	_	26	nummod	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	T-cell	t-cell	NN	NN	_	26	compound	_	_
26	leukemia	leukemia	NN	NN	_	20	conj	_	_
27	virus-infected	virus-infected	JJ	JJ	_	26	amod	_	_
28	human	human	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	20	dep	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	tax	tax	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	type	type	NN	NN	_	12	compound	_	_
8	I	i	CD	CD	_	12	nummod	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	T-cell	t-cell	NN	NN	_	12	compound	_	_
11	leukemia	leukemia	NN	NN	_	12	compound	_	_
12	virus	virus	NN	NN	_	4	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HTLV-I	htlv-i	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	transactivates	transactivate	VBZ	VBZ	_	0	root	_	_
17	interleukin-2	interleukin-2	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	IL-2	il-2	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	gene	gene	NN	NN	_	16	dobj	_	_
22	through	through	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	16	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	an	a	DT	DT	_	26	det	_	_
26	enhancer	enhancer	NN	NN	_	23	nmod	_	_
27	termed	term	VBN	VBN	_	26	acl	_	_
28	CD28	cd28	NN	NN	_	30	compound	_	_
29	responsive	responsive	JJ	JJ	_	30	amod	_	_
30	element	element	NN	NN	_	27	xcomp	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	CD28RE	cd28re	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	16	punct	_	_

1	Tax	tax	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	CD28RE	cd28re	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	partially	partially	RB	RB	_	8	advmod	_	_
8	mediated	mediate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	member	member	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	19	case	_	_
13	the	the	DT	DT	_	19	det	_	_
14	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
15	factor	factor	NN	NN	_	19	compound	_	_
16	of	of	IN	IN	_	19	amod	_	_
17	activated	activate	VBN	VBN	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	NF-AT1	nf-at1	NN	NN	_	19	appos	_	_
22	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	NF-AT1	nf-at1	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	active	active	JJ	JJ	_	4	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Jurkat	jurkat	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	stably	stably	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBN	VBN	_	13	acl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Tax	tax	NN	NN	_	19	compound	_	_
19	cDNA	cdna	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	although	although	IN	IN	_	32	mark	_	_
22	the	the	DT	DT	_	25	det	_	_
23	underlying	underlie	VBG	VBG	_	25	amod	_	_
24	molecular	molecular	JJ	JJ	_	25	amod	_	_
25	mechanism	mechanism	NN	NN	_	32	nsubj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	physiological	physiological	JJ	JJ	_	28	amod	_	_
28	relevance	relevance	NN	NN	_	25	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	finding	finding	NN	NN	_	28	nmod	_	_
32	remain	remain	VBP	VBP	_	9	advcl	_	_
33	unclear	unclear	JJ	JJ	_	32	xcomp	_	_
34	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	active	active	JJ	JJ	_	10	amod	_	_
10	form	form	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NF-AT1	nf-at1	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	present	present	JJ	JJ	_	6	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	nuclei	nucleus	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	express	express	VBP	VBP	_	18	acl:relcl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	Tax	tax	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	6	punct	_	_

1	Interestingly	interestingly	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	constitutive	constitutive	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-AT1	nf-at1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	these	these	DT	DT	_	11	det	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	dephosphorylation	dephosphorylation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	dephosphorylated	dephosphorylate	VBN	VBN	_	5	amod	_	_
5	NF-AT1	nf-at1	NN	NN	_	9	nsubjpass	_	_
6	can	can	MD	MD	_	9	aux	_	_
7	be	be	VB	VB	_	9	auxpass	_	_
8	rapidly	rapidly	RB	RB	_	9	advmod	_	_
9	rephosphorylated	rephosphorylate	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	the	the	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	14	nsubjpass	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	incubated	incubate	VBN	VBN	_	9	advcl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	cyclosporin	cyclosporin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	an	a	DT	DT	_	20	det	_	_
20	immunosuppressant	immunosuppressant	NN	NN	_	17	appos	_	_
21	inhibiting	inhibit	VBG	VBG	_	20	acl	_	_
22	the	the	DT	DT	_	24	det	_	_
23	serine/threonine	serine/threonine	NN	NN	_	24	compound	_	_
24	phosphatase	phosphatase	NN	NN	_	21	dobj	_	_
25	calcineurin	calcineurin	NN	NN	_	24	dep	_	_
26	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	activation	activation	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-AT1	nf-at1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	Tax-expressing	tax-expressing	JJ	JJ	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	9	conj	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	dep	_	_
14	results	result	VBZ	VBZ	_	3	ccomp	_	_
15	from	from	IN	IN	_	17	case	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	dephosphorylation	dephosphorylation	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	which	which	WDT	WDT	_	24	nsubj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	turn	turn	NN	NN	_	24	nmod	_	_
22	may	may	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	due	due	JJ	JJ	_	14	ccomp	_	_
25	to	to	TO	TO	_	26	case	_	_
26	deregulation	deregulation	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	calcineurin	calcineurin	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Elf-2	elf-2	NN	NN	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	8	det	_	_
4	rhombotin-2	rhombotin-2	NN	NN	_	8	compound	_	_
5	binding	binding	NN	NN	_	8	compound	_	_
6	ets	ets	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	1	appos	_	_
9	:	:	:	:	_	1	punct	_	_
10	discovery	discovery	NN	NN	_	1	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	potential	potential	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	leukemia	leukemia	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Rhombotin-2	rhombotin-2	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	RBTN-2	rbtn-2	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	proto-oncogene	proto-oncogene	NN	NN	_	0	root	_	_
8	only	only	RB	RB	_	11	advmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	context	context	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	postulated	postulate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	oncogenic	oncogenic	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	RBTN-2	rbtn-2	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	likely	likely	RB	RB	_	14	advmod	_	_
14	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
15	by	by	IN	IN	_	19	case	_	_
16	binding	bind	VBG	VBG	_	17	amod	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	s	s	NNS	NNS	_	14	nmod	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	with	with	IN	IN	_	24	case	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell-specific	cell-specific	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	screening	screen	VBG	VBG	_	10	advcl	_	_
3	a	a	DT	DT	_	5	det	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cell	cell	NN	NN	_	2	dobj	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	library	library	NN	NN	_	5	dep	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	identified	identify	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	15	det	_	_
12	novel	novel	JJ	JJ	_	15	amod	_	_
13	ets	ets	NN	NN	_	15	compound	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	10	dobj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	binds	bind	VBZ	VBZ	_	15	acl:relcl	_	_
18	RBTN-2	rbtn-2	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	named	name	VBN	VBN	_	0	root	_	_
5	elf-2	elf-2	NN	NN	_	4	xcomp	_	_
6	because	because	IN	IN	_	12	mark	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	virtually	virtually	RB	RB	_	12	advmod	_	_
12	identical	identical	JJ	JJ	_	4	advcl	_	_
13	to	to	TO	TO	_	14	case	_	_
14	that	that	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	ets	ets	NN	NN	_	18	compound	_	_
17	family	family	NN	NN	_	18	compound	_	_
18	member	member	NN	NN	_	14	nmod	_	_
19	elf-1	elf-1	NN	NN	_	18	dep	_	_
20	.	.	.	.	_	4	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	similar	similar	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	elf-2	elf-2	NN	NN	_	9	compound	_	_
9	transcripts	transcript	NNS	NNS	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	3.5	3.5	CD	CD	_	12	nummod	_	_
12	kb	kb	NN	NN	_	9	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	3.8	3.8	CD	CD	_	15	nummod	_	_
15	kb	kb	NN	NN	_	12	conj	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	all	all	DT	DT	_	19	det	_	_
19	tissues	tissue	NNS	NNS	_	3	nmod	_	_
20	except	except	IN	IN	_	21	case	_	_
21	thymus	thymus	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Thymocytes	thymocyte	NNS	NNS	_	2	nsubj	_	_
2	expressed	express	VBD	VBD	_	0	root	_	_
3	four-	four-	CD	CD	_	6	nmod:npmod	_	_
4	to	to	TO	TO	_	3	dep	_	_
5	10-fold	10-fold	RB	RB	_	3	advmod	_	_
6	greater	greater	JJR	JJR	_	7	amod	_	_
7	amounts	amount	NNS	NNS	_	2	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	3.5	3.5	CD	CD	_	12	nummod	_	_
11	kb	kb	NN	NN	_	12	compound	_	_
12	transcript	transcript	NN	NN	_	7	nmod	_	_
13	than	than	IN	IN	_	15	mark	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	tissues	tissue	NNS	NNS	_	7	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	2	nmod	_	_
6	indicated	indicate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	these	these	DT	DT	_	9	det	_	_
9	transcripts	transcript	NNS	NNS	_	10	nsubj	_	_
10	encode	encode	VBP	VBP	_	6	ccomp	_	_
11	proteins	protein	NNS	NNS	_	10	dobj	_	_
12	differing	differ	VBG	VBG	_	11	acl	_	_
13	only	only	RB	RB	_	17	advmod	_	_
14	at	at	IN	IN	_	17	case	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	amino	amino	NN	NN	_	17	compound	_	_
17	termini	terminus	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	likely	likely	RB	RB	_	21	advmod	_	_
21	represent	represent	VBP	VBP	_	10	conj	_	_
22	alternatively	alternatively	RB	RB	_	23	advmod	_	_
23	spliced	splice	VBN	VBN	_	24	amod	_	_
24	isoforms	isoform	NNS	NNS	_	21	dobj	_	_
25	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	isoforms	isoform	NNS	NNS	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	elf-2a	elf-2a	NN	NN	_	2	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	elf-2b	elf-2b	NN	NN	_	4	conj	_	_
7	)	)	-RRB-	-RRB-	_	4	punct	_	_
8	contain	contain	VBP	VBP	_	0	root	_	_
9	identical	identical	JJ	JJ	_	12	amod	_	_
10	RBTN-2	rbtn-2	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	regions	region	NNS	NNS	_	8	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	domains	domain	NNS	NNS	_	12	conj	_	_
16	.	.	.	.	_	8	punct	_	_

1	Elf-2b	elf-2b	NN	NN	_	2	nsubj	_	_
2	lacks	lack	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	putative	putative	JJ	JJ	_	6	amod	_	_
5	transactivation	transactivation	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	2	dobj	_	_
7	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	patterns	pattern	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	RBTN-2	rbtn-2	NN	NN	_	8	nsubj	_	_
7	normally	normally	RB	RB	_	8	advmod	_	_
8	interacts	interact	VBZ	VBZ	_	4	ccomp	_	_
9	equally	equally	RB	RB	_	8	advmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	elf-2a	elf-2a	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	elf-2b	elf-2b	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	when	when	WRB	WRB	_	8	advmod	_	_
5	RBTN-2	rbtn-2	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	inappropriately	inappropriately	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	15	advcl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	RBTN-2	rbtn-2	NN	NN	_	15	nsubj	_	_
14	would	would	MD	MD	_	15	aux	_	_
15	interact	interact	VB	VB	_	0	root	_	_
16	predominantly	predominantly	RB	RB	_	18	advmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	elf-2b	elf-2b	NN	NN	_	15	nmod	_	_
19	;	;	:	:	_	15	punct	_	_
20	this	this	DT	DT	_	21	det	_	_
21	interaction	interaction	NN	NN	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	lead	lead	VB	VB	_	15	parataxis	_	_
24	to	to	TO	TO	_	27	case	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	proliferation	proliferation	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	B-cell-specific	b-cell-specific	JJ	JJ	_	5	amod	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	for	for	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	transactivator	transactivator	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	transactivator	transactivator	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CIITA	ciita	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	essential	essential	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	22	case	_	_
14	major	major	JJ	JJ	_	22	amod	_	_
15	histocompatibility	histocompatibility	NN	NN	_	22	compound	_	_
16	complex	complex	NN	NN	_	22	compound	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	MHC	mhc	NN	NN	_	22	compound	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	antigens	antigen	NNS	NNS	_	12	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	tissular	tissular	JJ	JJ	_	3	amod	_	_
3	patterns	pattern	NNS	NNS	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CIITA	ciita	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	MHC	mhc	NN	NN	_	11	compound	_	_
8	class	class	NN	NN	_	11	compound	_	_
9	II	ii	CD	CD	_	11	nummod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	3	conj	_	_
12	are	be	VBP	VBP	_	14	auxpass	_	_
13	tightly	tightly	RB	RB	_	14	advmod	_	_
14	correlated	correlate	VBN	VBN	_	0	root	_	_
15	:	:	:	:	_	14	punct	_	_
16	CIITA	ciita	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	highly	highly	RB	RB	_	20	advmod	_	_
20	expressed	express	VBN	VBN	_	14	parataxis	_	_
21	in	in	IN	IN	_	23	case	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	induced	induce	VBN	VBN	_	20	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	interferon	interferon	NN	NN	_	30	compound	_	_
30	gamma	gamma	NN	NN	_	27	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	IFN-gamma	ifn-gamma	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	in	in	IN	IN	_	35	case	_	_
35	macrophage	macrophage	NN	NN	_	30	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	epithelial	epithelial	JJ	JJ	_	35	conj	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	lines	line	NNS	NNS	_	35	dep	_	_
40	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	first	first	RB	RB	_	3	advmod	_	_
3	isolated	isolate	VBD	VBD	_	0	root	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	overlapping	overlap	VBG	VBG	_	6	amod	_	_
6	cosmids	cosmid	NNS	NNS	_	3	dobj	_	_
7	encoding	encode	VBG	VBG	_	6	acl	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	CIITA	ciita	NN	NN	_	7	dobj	_	_
10	which	which	WDT	WDT	_	16	dep	_	_
11	,	,	,	,	_	16	punct	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	co-transfected	co-transfect	VBN	VBN	_	16	advcl	_	_
14	,	,	,	,	_	16	punct	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	able	able	JJ	JJ	_	6	acl:relcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	restore	restore	VB	VB	_	16	xcomp	_	_
19	MHC	mhc	NN	NN	_	20	compound	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	20	nummod	_	_
22	expression	expression	NN	NN	_	18	dobj	_	_
23	in	in	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	B-lymphoblastoid	b-lymphoblastoid	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	line	line	NN	NN	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	B-LCL	b-lcl	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	defective	defective	JJ	JJ	_	27	amod	_	_
32	for	for	IN	IN	_	33	case	_	_
33	CIITA	ciita	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Subsequently	subsequently	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	a	a	DT	DT	_	9	det	_	_
4	1.8	1.8	CD	CD	_	9	nummod	_	_
5	kilobase	kilobase	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	kb	kb	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	fragment	fragment	NN	NN	_	15	nsubjpass	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CIITA	ciita	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	isolated	isolate	VBN	VBN	_	0	root	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	sequenced	sequence	VBN	VBN	_	15	conj	_	_
18	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	motif	motif	NN	NN	_	11	nsubjpass	_	_
3	presenting	present	VBG	VBG	_	2	acl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	strong	strong	JJ	JJ	_	6	amod	_	_
6	similarity	similarity	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	initiator	initiator	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	as	as	RB	RB	_	11	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	putative	putative	JJ	JJ	_	18	amod	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	sites	site	NNS	NNS	_	11	conj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	Sp1	sp1	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	GATA-2	gata-2	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	LyF-1	lyf-1	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	ets-1	ets-1	NN	NN	_	20	conj	_	_
27	,	,	,	,	_	20	punct	_	_
28	AP1	ap1	NN	NN	_	20	conj	_	_
29	,	,	,	,	_	20	punct	_	_
30	and	and	CC	CC	_	20	cc	_	_
31	MZF1	mzf1	NN	NN	_	20	conj	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factors	factor	NNS	NNS	_	20	dep	_	_
34	,	,	,	,	_	20	punct	_	_
35	and	and	CC	CC	_	20	cc	_	_
36	two	two	CD	CD	_	38	nummod	_	_
37	GAS	gas	NN	NN	_	38	compound	_	_
38	motifs	motif	NNS	NNS	_	20	conj	_	_
39	.	.	.	.	_	11	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	introduced	introduce	VBN	VBN	_	14	advcl	_	_
3	in	in	IN	IN	_	4	case	_	_
4	front	front	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	luciferase	luciferase	NN	NN	_	9	compound	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	this	this	DT	DT	_	12	det	_	_
12	promoter	promoter	NN	NN	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	able	able	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	direct	direct	VB	VB	_	14	xcomp	_	_
17	a	a	DT	DT	_	20	det	_	_
18	high	high	JJ	JJ	_	20	amod	_	_
19	luciferase	luciferase	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	B-LCL	b-lcl	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	luciferase	luciferase	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	stimulated	stimulate	VBN	VBN	_	0	root	_	_
9	after	after	IN	IN	_	11	case	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	11	compound	_	_
11	treatment	treatment	NN	NN	_	8	nmod	_	_
12	when	when	WRB	WRB	_	16	advmod	_	_
13	the	the	DT	DT	_	14	det	_	_
14	construct	construct	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	transfected	transfect	VBN	VBN	_	8	advcl	_	_
17	in	in	IN	IN	_	18	case	_	_
18	macrophage	macrophage	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	23	case	_	_
21	epithelial	epithelial	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	induction	induction	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	CIITA	ciita	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	mouse	mouse	NN	NN	_	14	compound	_	_
14	macrophage	macrophage	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	fibrosarcoma	fibrosarcoma	NN	NN	_	14	conj	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	14	dep	_	_
19	,	,	,	,	_	11	punct	_	_
20	when	when	WRB	WRB	_	24	advmod	_	_
21	the	the	DT	DT	_	22	det	_	_
22	cells	cell	NNS	NNS	_	24	nsubjpass	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	transfected	transfect	VBN	VBN	_	11	advcl	_	_
25	with	with	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	cosmid	cosmid	NN	NN	_	24	nmod	_	_
28	containing	contain	VBG	VBG	_	27	dep	_	_
29	the	the	DT	DT	_	32	det	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	CIITA	ciita	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	28	dobj	_	_
33	,	,	,	,	_	28	punct	_	_
34	but	but	CC	CC	_	28	cc	_	_
35	lacking	lack	VBG	VBG	_	28	conj	_	_
36	the	the	DT	DT	_	39	det	_	_
37	1.8	1.8	CD	CD	_	39	nummod	_	_
38	kb	kb	NN	NN	_	39	compound	_	_
39	promoter	promoter	NN	NN	_	35	dobj	_	_
40	described	describe	VBN	VBN	_	39	acl	_	_
41	above	above	RB	RB	_	40	advmod	_	_
42	.	.	.	.	_	11	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	the	the	DT	DT	_	8	det	_	_
8	existence	existence	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	intragenic	intragenic	JJ	JJ	_	12	amod	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	driving	drive	VBG	VBG	_	12	acl	_	_
14	an	a	DT	DT	_	16	det	_	_
15	IFN-gamma-inducible	ifn-gamma-inducible	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	CIITA	ciita	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Shared	shared	JJ	JJ	_	3	amod	_	_
2	gamma(c)	gamma(c)	NN	NN	_	3	compound	_	_
3	subunit	subunit	NN	NN	_	0	root	_	_
4	within	within	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	interleukin-7	interleukin-7	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	complex	complex	NN	NN	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	pathogenesis	pathogenesis	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	X-linked	x-linked	JJ	JJ	_	11	amod	_	_
9	severe	severe	JJ	JJ	_	11	amod	_	_
10	combined	combined	JJ	JJ	_	11	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Genetic	genetic	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	mutations	mutation	NNS	NNS	_	11	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	gamma(c)	gamma(c)	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	subunit	subunit	NN	NN	_	5	nmod	_	_
11	cause	cause	VBP	VBP	_	3	ccomp	_	_
12	X-linked	x-linked	JJ	JJ	_	15	amod	_	_
13	severe	severe	JJ	JJ	_	15	amod	_	_
14	combined	combined	JJ	JJ	_	15	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	11	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	X-SCID	x-scid	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	gamma(c)	gamma(c)	NN	NN	_	3	compound	_	_
3	subunit	subunit	NN	NN	_	6	nsubjpass	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	employed	employ	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	complexes	complex	NNS	NNS	_	6	nmod	_	_
10	for	for	IN	IN	_	11	case	_	_
11	IL-2	il-2	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	-4	-4	CD	CD	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	-7	-7	CD	CD	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	-9	-9	CD	CD	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	-15	-15	CD	CD	_	11	conj	_	_
21	,	,	,	,	_	6	punct	_	_
22	and	and	CC	CC	_	6	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	multiple	multiple	JJ	JJ	_	26	amod	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	defects	defect	NNS	NNS	_	39	nsubjpass	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	would	would	MD	MD	_	29	aux	_	_
29	result	result	VB	VB	_	26	acl:relcl	_	_
30	from	from	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	defective	defective	JJ	JJ	_	34	amod	_	_
33	gamma(c)	gamma(c)	NN	NN	_	34	compound	_	_
34	chain	chain	NN	NN	_	29	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	these	these	DT	DT	_	37	det	_	_
37	receptors	receptor	NNS	NNS	_	34	nmod	_	_
38	are	be	VBP	VBP	_	39	auxpass	_	_
39	proposed	propose	VBN	VBN	_	6	conj	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	cause	cause	VB	VB	_	39	xcomp	_	_
42	the	the	DT	DT	_	44	det	_	_
43	severe	severe	JJ	JJ	_	44	amod	_	_
44	phenotype	phenotype	NN	NN	_	41	dobj	_	_
45	of	of	IN	IN	_	47	case	_	_
46	X-SCID	x-scid	NN	NN	_	47	compound	_	_
47	patients	patient	NNS	NNS	_	44	nmod	_	_
48	.	.	.	.	_	6	punct	_	_

1	Interestingly	interestingly	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	disruption	disruption	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	either	either	CC	CC	_	7	cc:preconj	_	_
7	IL-7	il-7	NN	NN	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	16	det	_	_
10	IL-7	il-7	NN	NN	_	16	compound	_	_
11	receptor	receptor	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	IL-7R	il-7r	NN	NN	_	16	compound	_	_
14	)	)	-RRB-	-RRB-	_	16	punct	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	subunit	subunit	NN	NN	_	7	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	mice	mouse	NNS	NNS	_	4	nmod	_	_
19	leads	lead	VBZ	VBZ	_	0	root	_	_
20	to	to	TO	TO	_	22	case	_	_
21	immunological	immunological	JJ	JJ	_	22	amod	_	_
22	defects	defect	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	similar	similar	JJ	JJ	_	22	acl:relcl	_	_
26	to	to	TO	TO	_	28	case	_	_
27	human	human	JJ	JJ	_	28	amod	_	_
28	X-SCID	x-scid	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	importance	importance	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	gamma(c)	gamma(c)	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-7R	il-7r	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	structure/function	structure/function	NN	NN	_	7	compound	_	_
7	analyses	analysis	NNS	NNS	_	17	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-7R	il-7r	NN	NN	_	11	compound	_	_
11	complex	complex	NN	NN	_	7	nmod	_	_
12	using	use	VBG	VBG	_	7	acl	_	_
13	a	a	DT	DT	_	16	det	_	_
14	chimeric	chimeric	JJ	JJ	_	15	amod	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	system	system	NN	NN	_	12	dobj	_	_
17	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	gamma(c)	gamma(c)	NN	NN	_	22	nsubj	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	indeed	indeed	RB	RB	_	22	advmod	_	_
22	critical	critical	JJ	JJ	_	17	ccomp	_	_
23	for	for	IN	IN	_	25	case	_	_
24	IL-7R	il-7r	NN	NN	_	25	compound	_	_
25	function	function	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	17	punct	_	_

1	Nonetheless	nonetheless	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	only	only	RB	RB	_	6	advmod	_	_
4	a	a	DT	DT	_	6	det	_	_
5	limited	limited	JJ	JJ	_	6	amod	_	_
6	portion	portion	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	gamma(c)	gamma(c)	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	necessary	necessary	JJ	JJ	_	0	root	_	_
15	for	for	IN	IN	_	18	case	_	_
16	IL-7R	il-7r	NN	NN	_	18	compound	_	_
17	signal	signal	NN	NN	_	18	compound	_	_
18	transduction	transduction	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	replacement	replacement	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	gamma(c)	gamma(c)	NN	NN	_	3	nmod	_	_
7	cytoplasmic	cytoplasmic	JJ	JJ	_	8	amod	_	_
8	domain	domain	NN	NN	_	6	dep	_	_
9	by	by	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	severely	severely	RB	RB	_	14	advmod	_	_
12	truncated	truncate	VBN	VBN	_	14	amod	_	_
13	erythropoeitin	erythropoeitin	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	3	nmod	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	affect	affect	VB	VB	_	0	root	_	_
18	measured	measure	VBN	VBN	_	21	amod	_	_
19	IL-7R	il-7r	NN	NN	_	21	compound	_	_
20	signaling	signaling	NN	NN	_	21	compound	_	_
21	events	event	NNS	NNS	_	17	dobj	_	_
22	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	9	nmod	_	_
8	gamma(c)	gamma(c)	NN	NN	_	9	nsubj	_	_
9	serves	serve	VBZ	VBZ	_	5	acl:relcl	_	_
10	primarily	primarily	RB	RB	_	12	advmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	activate	activate	VB	VB	_	9	xcomp	_	_
13	signal	signal	NN	NN	_	14	compound	_	_
14	transduction	transduction	NN	NN	_	12	dobj	_	_
15	by	by	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	IL-7R	il-7r	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	while	while	IN	IN	_	23	mark	_	_
21	IL-7R	il-7r	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	23	nsubj	_	_
23	determines	determine	VBZ	VBZ	_	9	advcl	_	_
24	specific	specific	JJ	JJ	_	26	amod	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	events	event	NNS	NNS	_	23	dobj	_	_
27	through	through	IN	IN	_	29	case	_	_
28	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
29	association	association	NN	NN	_	23	nmod	_	_
30	with	with	IN	IN	_	33	case	_	_
31	cytoplasmic	cytoplasmic	JJ	JJ	_	33	amod	_	_
32	signaling	signaling	NN	NN	_	33	compound	_	_
33	molecules	molecule	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	consistent	consistent	JJ	JJ	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	hypothesis	hypothesis	NN	NN	_	6	nmod	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	pathogenesis	pathogenesis	NN	NN	_	17	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	X-SCID	x-scid	NN	NN	_	13	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	due	due	JJ	JJ	_	9	ccomp	_	_
18	primarily	primarily	RB	RB	_	21	advmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	gamma(c)-mediated	gamma(c)-mediated	JJ	JJ	_	21	amod	_	_
21	defects	defect	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	IL-7/IL-7R	il-7/il-7r	NN	NN	_	25	compound	_	_
25	system	system	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	V3	v3	NN	NN	_	2	compound	_	_
2	loop	loop	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	2	nmod	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
10	interleukin	interleukin	NN	NN	_	14	compound	_	_
11	2-induced	2-induced	JJ	JJ	_	14	amod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	growth	growth	NN	NN	_	9	dobj	_	_
15	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
16	published	publish	VBN	VBN	_	17	amod	_	_
17	erratum	erratum	NN	NN	_	18	nsubj	_	_
18	appears	appear	VBZ	VBZ	_	9	parataxis	_	_
19	in	in	IN	IN	_	23	case	_	_
20	AIDS	AIDS	NNP	NNP	_	23	compound	_	_
21	Res	Res	NNP	NNP	_	23	compound	_	_
22	Hum	Hum	NNP	NNP	_	23	compound	_	_
23	Retroviruses	Retroviruses	NNPS	NNPS	_	18	nmod	_	_
24	1997	1997	CD	CD	_	25	nummod	_	_
25	May	may	NN	NN	_	23	dep	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	;	;	:	:	_	23	punct	_	_
28	13	13	CD	CD	_	30	nummod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	7	7	CD	CD	_	23	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	:	:	:	:	_	23	punct	_	_
33	633	633	CD	CD	_	23	dep	_	_
34	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	tested	test	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	three	three	CD	CD	_	7	nummod	_	_
7	linear	linear	JJ	JJ	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	two	two	CD	CD	_	10	nummod	_	_
10	loop	loop	NN	NN	_	7	conj	_	_
11	peptides	peptide	NNS	NNS	_	7	dep	_	_
12	derived	derive	VBN	VBN	_	7	acl	_	_
13	from	from	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	V3	v3	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	HTLV-III	htlv-iii	NN	NN	_	21	compound	_	_
20	BH10	bh10	NN	NN	_	21	compound	_	_
21	clone	clone	NN	NN	_	16	nmod	_	_
22	or	or	CC	CC	_	16	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	SF2	sf2	NN	NN	_	25	compound	_	_
25	strain	strain	NN	NN	_	16	conj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	human	human	JJ	JJ	_	30	amod	_	_
28	immunodeficiency	immunodeficiency	NN	NN	_	30	compound	_	_
29	virus	virus	NN	NN	_	30	compound	_	_
30	type	type	NN	NN	_	25	nmod	_	_
31	1	1	CD	CD	_	30	nummod	_	_
32	on	on	IN	IN	_	36	case	_	_
33	IL-2-driven	il-2-driven	JJ	JJ	_	36	amod	_	_
34	T	t	NN	NN	_	36	compound	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	proliferation	proliferation	NN	NN	_	4	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	V3-BH10	v3-bh10	NN	NN	_	15	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	4	nsubj	_	_
4	consists	consist	VBZ	VBZ	_	1	acl:relcl	_	_
5	of	of	IN	IN	_	8	case	_	_
6	42	42	CD	CD	_	8	nummod	_	_
7	amino	amino	NN	NN	_	8	compound	_	_
8	acids	acid	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	has	have	VBZ	VBZ	_	4	conj	_	_
11	a	a	DT	DT	_	13	det	_	_
12	loop	loop	NN	NN	_	13	compound	_	_
13	structure	structure	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	1	punct	_	_
15	suppressed	suppress	VBD	VBD	_	0	root	_	_
16	IL-2-driven	il-2-driven	JJ	JJ	_	17	amod	_	_
17	proliferation	proliferation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	all	all	DT	DT	_	21	det	_	_
20	IL-2-dependent	il-2-dependent	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
23	Kit225	kit225	NN	NN	_	21	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	ED-40515(+)	ed-40515(+)	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	KT-3	kt-3	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	7-day	7-day	JJ	JJ	_	30	amod	_	_
30	PHA-blasts	pha-blast	NNS	NNS	_	23	conj	_	_
31	,	,	,	,	_	23	punct	_	_
32	and	and	CC	CC	_	23	cc	_	_
33	fresh	fresh	JJ	JJ	_	37	amod	_	_
34	peripheral	peripheral	JJ	JJ	_	37	amod	_	_
35	blood	blood	NN	NN	_	37	compound	_	_
36	mononuclear	mononuclear	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	23	conj	_	_
38	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_
39	tested	test	VBN	VBN	_	21	acl	_	_
40	,	,	,	,	_	15	punct	_	_
41	whereas	whereas	IN	IN	_	45	mark	_	_
42	it	it	PRP	PRP	_	45	nsubj	_	_
43	did	do	VBD	VBD	_	45	aux	_	_
44	not	not	RB	RB	_	45	neg	_	_
45	suppress	suppress	VB	VB	_	15	advcl	_	_
46	the	the	DT	DT	_	48	det	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	growth	growth	NN	NN	_	45	dobj	_	_
49	of	of	IN	IN	_	52	case	_	_
50	IL-2-independent	il-2-independent	JJ	JJ	_	52	amod	_	_
51	cell	cell	NN	NN	_	52	compound	_	_
52	lines	line	NNS	NNS	_	48	nmod	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	Hut102	hut102	NN	NN	_	52	dep	_	_
55	,	,	,	,	_	54	punct	_	_
56	Molt-4	molt-4	NN	NN	_	54	conj	_	_
57	,	,	,	,	_	54	punct	_	_
58	and	and	CC	CC	_	54	cc	_	_
59	Jurkat	jurkat	NN	NN	_	54	conj	_	_
60	)	)	-RRB-	-RRB-	_	54	punct	_	_
61	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	suppressive	suppressive	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	seen	see	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	IL-2-driven	il-2-driven	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	growth	growth	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CD8-positive	cd8-positive	JJ	JJ	_	13	amod	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	purified	purify	VBN	VBN	_	13	acl	_	_
15	from	from	IN	IN	_	17	case	_	_
16	7-day	7-day	JJ	JJ	_	17	amod	_	_
17	PHA-blasts	pha-blast	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	indicating	indicate	VBG	VBG	_	6	advcl	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	CD4	cd4	NN	NN	_	22	compound	_	_
22	molecules	molecule	NNS	NNS	_	25	nsubjpass	_	_
23	were	be	VBD	VBD	_	25	auxpass	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	required	require	VBN	VBN	_	19	ccomp	_	_
26	for	for	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	suppression	suppression	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	treatment	treatment	NN	NN	_	13	nsubj	_	_
3	with	with	IN	IN	_	7	case	_	_
4	anti-V3	anti-v3	JJ	JJ	_	7	amod	_	_
5	loop	loop	NN	NN	_	7	compound	_	_
6	monoclonal	monoclonal	JJ	JJ	_	7	amod	_	_
7	antibody	antibody	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	902	902	CD	CD	_	10	nummod	_	_
10	antibody	antibody	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	completely	completely	RB	RB	_	13	advmod	_	_
13	abolished	abolish	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	16	det	_	_
15	suppressive	suppressive	JJ	JJ	_	16	amod	_	_
16	effect	effect	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	V3-BH10	v3-bh10	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	V3-BH10	v3-bh10	NN	NN	_	5	nsubj	_	_
5	generated	generate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	arrest	arrest	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Kit225	kit225	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	also	also	RB	RB	_	15	advmod	_	_
13	purified	purify	VBD	VBD	_	15	amod	_	_
14	CD8-positive	cd8-positive	JJ	JJ	_	15	amod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	G1	g1	NN	NN	_	18	compound	_	_
18	phase	phase	NN	NN	_	7	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	7	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Neither	neither	CC	CC	_	3	cc:preconj	_	_
2	chromatin	chromatin	NN	NN	_	3	compound	_	_
3	condensation	condensation	NN	NN	_	8	nsubjpass	_	_
4	nor	nor	CC	CC	_	3	cc	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	fragmentation	fragmentation	NN	NN	_	3	conj	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Kit225	kit225	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	cultured	culture	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	V3-BH10	v3-bh10	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-2	il-2	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	8	punct	_	_

1	V3-BH10	v3-bh10	NN	NN	_	3	nsubj	_	_
2	neither	neither	CC	CC	_	3	cc:preconj	_	_
3	blocked	block	VBD	VBD	_	0	root	_	_
4	radiolabeled	radiolabele	VBN	VBN	_	6	amod	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	6	nmod	_	_
10	nor	nor	CC	CC	_	3	cc	_	_
11	affected	affect	VBD	VBD	_	3	conj	_	_
12	tyrosyl	tyrosyl	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	several	several	JJ	JJ	_	17	amod	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	proteins	protein	NNS	NNS	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	p120	p120	NN	NN	_	17	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	p98	p98	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	p96	p96	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	p54	p54	NN	NN	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	p38	p38	NN	NN	_	19	conj	_	_
29	)	)	-RRB-	-RRB-	_	19	punct	_	_
30	,	,	,	,	_	13	punct	_	_
31	which	which	WDT	WDT	_	34	nsubjpass	_	_
32	is	be	VBZ	VBZ	_	34	auxpass	_	_
33	immediately	immediately	RB	RB	_	34	advmod	_	_
34	induced	induce	VBN	VBN	_	13	acl:relcl	_	_
35	by	by	IN	IN	_	37	case	_	_
36	IL-2	il-2	NN	NN	_	37	compound	_	_
37	stimulation	stimulation	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	V3-BH10	v3-bh10	NN	NN	_	4	nsubj	_	_
4	enhanced	enhance	VBD	VBD	_	0	root	_	_
5	IL-2-induced	il-2-induced	JJ	JJ	_	7	amod	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	c-fos	c-fos	NN	NN	_	7	nmod	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	c-myc	c-myc	NN	NN	_	9	conj	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	junB	junb	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	binding	binding	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	V3	v3	NN	NN	_	7	compound	_	_
7	loop	loop	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	gp120	gp120	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	cell	cell	NN	NN	_	16	compound	_	_
13	surface	surface	NN	NN	_	16	compound	_	_
14	molecule	molecule	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	s	s	NNS	NNS	_	4	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	appears	appear	VBZ	VBZ	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	affect	affect	VB	VB	_	18	xcomp	_	_
21	intracellular	intracellular	JJ	JJ	_	23	amod	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	signaling	signaling	NN	NN	_	20	dobj	_	_
24	,	,	,	,	_	23	punct	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	leads	lead	VBZ	VBZ	_	23	acl:relcl	_	_
27	to	to	TO	TO	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	suppression	suppression	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	34	case	_	_
31	IL-2-induced	il-2-induced	JJ	JJ	_	34	amod	_	_
32	T	t	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	growth	growth	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	18	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor-kappaB	factor-kappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	11	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
7	stimulated	stimulate	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	fibroblast	fibroblast	NN	NN	_	15	compound	_	_
14	conditioned	conditioned	JJ	JJ	_	15	amod	_	_
15	medium	medium	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	exogenous	exogenous	JJ	JJ	_	18	amod	_	_
18	PGE2	pge2	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	kappaB	kappab	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	thought	think	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	13	mark	_	_
11	be	be	VB	VB	_	13	auxpass	_	_
12	crucially	crucially	RB	RB	_	13	advmod	_	_
13	involved	involve	VBN	VBN	_	9	xcomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	several	several	JJ	JJ	_	20	amod	_	_
20	cytokines	cytokine	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	including	include	VBG	VBG	_	26	case	_	_
23	tumor	tumor	NN	NN	_	26	compound	_	_
24	necrosis	necrosis	NN	NN	_	26	compound	_	_
25	factor	factor	NN	NN	_	26	compound	_	_
26	alpha	alpha	NN	NN	_	20	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	TNF	tnf	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	9	punct	_	_

1	Previously	previously	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	fibroblast	fibroblast	NN	NN	_	8	compound	_	_
7	conditioned	conditioned	JJ	JJ	_	8	amod	_	_
8	medium	medium	NN	NN	_	13	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	FCM	fcm	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	able	able	JJ	JJ	_	4	ccomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	inhibit	inhibit	VB	VB	_	13	xcomp	_	_
16	both	both	CC	CC	_	19	cc:preconj	_	_
17	TNF	tnf	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	accumulation	accumulation	NN	NN	_	15	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	release	release	NN	NN	_	19	conj	_	_
23	in	in	IN	IN	_	27	case	_	_
24	peripheral	peripheral	JJ	JJ	_	27	amod	_	_
25	blood-derived	blood-derived	JJ	JJ	_	27	amod	_	_
26	human	human	JJ	JJ	_	27	amod	_	_
27	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	PBM	pbm	NNS	NNS	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	stimulated	stimulate	VBN	VBN	_	27	acl	_	_
32	with	with	IN	IN	_	33	case	_	_
33	lipopolysaccharide	lipopolysaccharide	NN	NN	_	31	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	LPS	lps	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	investigated	investigate	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	FCM	fcm	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	LPS-induced	lps-induced	JJ	JJ	_	15	amod	_	_
14	DNA-binding	dna-binding	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	by	by	IN	IN	_	20	case	_	_
20	means	means	NNS	NNS	_	6	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	electrophoretic	electrophoretic	JJ	JJ	_	24	amod	_	_
23	shift	shift	NN	NN	_	24	compound	_	_
24	assay	assay	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	EMSA	emsa	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	FCM	fcm	NN	NN	_	7	nsubj	_	_
6	strongly	strongly	RB	RB	_	7	advmod	_	_
7	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	LPS-induced	lps-induced	JJ	JJ	_	11	amod	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	PBM	pbm	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	exogenous	exogenous	JJ	JJ	_	7	amod	_	_
7	PGE2	pge2	NN	NN	_	8	nsubj	_	_
8	mimics	mimic	VBZ	VBZ	_	4	ccomp	_	_
9	the	the	DT	DT	_	12	det	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
11	inhibitory	inhibitory	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	FCM	fcm	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	FCM	fcm	NN	NN	_	15	nsubj	_	_
7	produced	produce	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	indomethacin	indomethacin	NN	NN	_	10	nmod	_	_
13	does	do	VBZ	VBZ	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	inhibit	inhibit	VB	VB	_	0	root	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	LPS	lps	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	lend	lend	VBP	VBP	_	0	root	_	_
4	further	further	JJ	JJ	_	5	amod	_	_
5	support	support	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	hypothesis	hypothesis	NN	NN	_	3	nmod	_	_
9	that	that	IN	IN	_	18	mark	_	_
10	inflammatory	inflammatory	JJ	JJ	_	18	nsubjpass	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	immune	immune	JJ	JJ	_	10	conj	_	_
13	responses	response	NNS	NNS	_	10	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	10	nmod	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	modulated	modulate	VBN	VBN	_	8	ccomp	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	molecular	molecular	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	18	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	signals	signal	NNS	NNS	_	18	nmod	_	_
25	originating	originate	VBG	VBG	_	24	acl	_	_
26	from	from	IN	IN	_	29	case	_	_
27	tissue	tissue	NN	NN	_	29	compound	_	_
28	structural	structural	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	such	such	JJ	JJ	_	32	case	_	_
31	as	as	IN	IN	_	30	mwe	_	_
32	fibroblasts	fibroblast	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	interaction	interaction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	PRE-I	pre-i	NN	NN	_	10	compound	_	_
9	enhancer	enhancer	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	IL-4	il-4	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	different	different	JJ	JJ	_	20	amod	_	_
18	T	t	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	subsets	subset	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunomodulatory	immunomodulatory	JJ	JJ	_	3	amod	_	_
3	cytokine	cytokine	NN	NN	_	5	nsubj	_	_
4	IL-4	il-4	NN	NN	_	3	dep	_	_
5	affects	affect	VBZ	VBZ	_	0	root	_	_
6	cells	cell	NNS	NNS	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	most	most	JJS	JJS	_	10	amod	_	_
9	hemopoietic	hemopoietic	JJ	JJ	_	10	amod	_	_
10	lineages	lineage	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	IL-4	il-4	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	secreted	secrete	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	Th2	th2	NN	NN	_	3	nmod	_	_
7	but	but	CC	CC	_	6	cc	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	Th1	th1	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	conj	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	plays	play	VBZ	VBZ	_	3	conj	_	_
13	a	a	DT	DT	_	15	det	_	_
14	major	major	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	12	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	modulating	modulate	VBG	VBG	_	12	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	differentiation	differentiation	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	naive	naive	JJ	JJ	_	27	amod	_	_
26	Th	th	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	toward	toward	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	Th2	th2	NN	NN	_	31	compound	_	_
31	phenotype	phenotype	NN	NN	_	23	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	PRE-I	pre-i	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	essential	essential	JJ	JJ	_	7	acl:relcl	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	function	function	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	IL-4	il-4	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	responsible	responsible	JJ	JJ	_	4	amod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	tissue-specific	tissue-specific	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-4	il-4	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	analyzed	analyze	VBD	VBD	_	2	parataxis	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	15	dobj	_	_
18	binding	bind	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	PRE-I	pre-i	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	compared	compare	VBD	VBD	_	15	conj	_	_
25	the	the	DT	DT	_	27	det	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	activities	activity	NNS	NNS	_	24	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	factors	factor	NNS	NNS	_	27	nmod	_	_
31	to	to	TO	TO	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	IL-4	il-4	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	24	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	Th1	th1	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	Th2	th2	NN	NN	_	36	conj	_	_
39	cells	cell	NNS	NNS	_	36	dep	_	_
40	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	PRE-I	pre-i	NN	NN	_	5	nsubj	_	_
5	interacts	interact	VBZ	VBZ	_	2	ccomp	_	_
6	with	with	IN	IN	_	14	case	_	_
7	PMA-	pma-	NN	NN	_	14	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	PMA/ionomycin-inducible	pma/ionomycin-inducible	JJ	JJ	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	nmod:npmod	_	_
12	A-sensitive	a-sensitive	JJ	JJ	_	7	dep	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	5	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	anti-C/EBPbeta	anti-c/ebpbeta	JJ	JJ	_	1	dobj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	NF-IL6	nf-il6	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	anti-C/EBPdelta	anti-c/ebpdelta	JJ	JJ	_	2	conj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NF-IL6beta	nf-il6beta	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	2	punct	_	_
12	anti-NF-ATc	anti-nf-atc	JJ	JJ	_	2	conj	_	_
13	,	,	,	,	_	2	punct	_	_
14	anti-NF-ATp	anti-nf-atp	JJ	JJ	_	2	conj	_	_
15	,	,	,	,	_	2	punct	_	_
16	anti-Fos	anti-fos	JJ	JJ	_	2	conj	_	_
17	,	,	,	,	_	2	punct	_	_
18	and	and	CC	CC	_	2	cc	_	_
19	anti-Jun	anti-jun	JJ	JJ	_	20	amod	_	_
20	Abs	ab	NNS	NNS	_	2	conj	_	_
21	we	we	PRP	PRP	_	22	nsubj	_	_
22	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
23	that	that	IN	IN	_	32	mark	_	_
24	the	the	DT	DT	_	29	det	_	_
25	previously	previously	RB	RB	_	26	advmod	_	_
26	identified	identify	VBN	VBN	_	29	amod	_	_
27	PRE-I	pre-i	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	32	nsubjpass	_	_
30	POS-1	pos-1	NN	NN	_	29	dep	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	composed	compose	VBN	VBN	_	22	ccomp	_	_
33	of	of	IN	IN	_	36	case	_	_
34	different	different	JJ	JJ	_	36	amod	_	_
35	transcription	transcription	NN	NN	_	36	compound	_	_
36	factors	factor	NNS	NNS	_	32	nmod	_	_
37	in	in	IN	IN	_	41	case	_	_
38	different	different	JJ	JJ	_	41	amod	_	_
39	Th	th	NN	NN	_	41	compound	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	subsets	subset	NNS	NNS	_	36	nmod	_	_
42	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	dep	_	_
3	IL-4-producing	il-4-producing	JJ	JJ	_	6	amod	_	_
4	Th0-like	th0-like	JJ	JJ	_	6	amod	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	Jurkat	jurkat	NN	NN	_	17	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	mouse	mouse	NN	NN	_	10	compound	_	_
9	EL-4	el-4	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	conj	_	_
11	,	,	,	,	_	17	punct	_	_
12	POS-1	pos-1	NN	NN	_	17	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	designated	designate	VBN	VBN	_	12	dep	_	_
15	POS-1a	pos-1a	NN	NN	_	14	xcomp	_	_
16	)	)	-RRB-	-RRB-	_	14	punct	_	_
17	contains	contain	VBZ	VBZ	_	0	root	_	_
18	NF-IL6beta	nf-il6beta	NN	NN	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	Jun	jun	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	mouse	mouse	NN	NN	_	6	compound	_	_
4	Th2	th2	NN	NN	_	6	compound	_	_
5	D10	d10	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	19	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	Th2	th2	NN	NN	_	12	compound	_	_
12	clones	clone	NNS	NNS	_	6	conj	_	_
13	,	,	,	,	_	19	punct	_	_
14	POS-1	pos-1	NN	NN	_	19	nsubj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	designated	designate	VBN	VBN	_	14	dep	_	_
17	POS-1b	pos-1b	NN	NN	_	16	xcomp	_	_
18	)	)	-RRB-	-RRB-	_	16	punct	_	_
19	contains	contain	VBZ	VBZ	_	0	root	_	_
20	NF-IL6beta	nf-il6beta	NN	NN	_	19	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	Jun	jun	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	NF-ATc/p	nf-atc/p	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	POS-1	pos-1	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	extracts	extract	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	Th1	th1	NN	NN	_	14	compound	_	_
14	clones	clone	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PRE-I	pre-i	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	play	play	VB	VB	_	3	ccomp	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	differential	differential	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	IL-4	il-4	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	18	compound	_	_
17	expression	expression	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Inhibitory	inhibitory	JJ	JJ	_	2	amod	_	_
2	effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	growth	growth	NN	NN	_	5	compound	_	_
5	hormone	hormone	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	8	compound	_	_
8	secretion	secretion	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor-kappaB	factor-kappab	NN	NN	_	12	compound	_	_
12	translocation	translocation	NN	NN	_	8	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	16	amod	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	pointed	point	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	link	link	NN	NN	_	4	nmod	_	_
8	between	between	IN	IN	_	9	case	_	_
9	immune	immune	JJ	JJ	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	endocrine	endocrine	JJ	JJ	_	9	conj	_	_
12	systems	system	NNS	NNS	_	9	dep	_	_
13	,	,	,	,	_	9	punct	_	_
14	including	include	VBG	VBG	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	function	function	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	GH	gh	NN	NN	_	17	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	monocyte	monocyte	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	25	mark	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	THP-1	thp-1	NN	NN	_	9	compound	_	_
8	promonocytic	promonocytic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	25	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	engineered	engineer	VBN	VBN	_	9	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	transfer	transfer	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	constitutively	constitutively	RB	RB	_	17	advmod	_	_
17	produce	produce	VB	VB	_	11	xcomp	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	growth	growth	NN	NN	_	20	compound	_	_
20	hormone	hormone	NN	NN	_	17	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	hGH	hgh	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	9	punct	_	_
25	secreted	secrete	VBD	VBD	_	4	ccomp	_	_
26	depressed	depress	VBN	VBN	_	27	amod	_	_
27	amounts	amount	NNS	NNS	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	TNF-alpha	tnf-alpha	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	response	response	NN	NN	_	25	nmod	_	_
32	to	to	TO	TO	_	33	case	_	_
33	challenge	challenge	NN	NN	_	31	nmod	_	_
34	by	by	IN	IN	_	35	case	_	_
35	LPS	lps	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GH	gh	NN	NN	_	2	nmod	_	_
5	appears	appear	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	occur	occur	VB	VB	_	5	xcomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	autocrine	autocrine	JJ	JJ	_	11	amod	_	_
11	fashion	fashion	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	since	since	IN	IN	_	26	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	inhibitory	inhibitory	JJ	JJ	_	16	amod	_	_
16	effect	effect	NN	NN	_	26	nsubjpass	_	_
17	on	on	IN	IN	_	19	case	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	19	compound	_	_
19	secretion	secretion	NN	NN	_	16	nmod	_	_
20	by	by	IN	IN	_	23	case	_	_
21	constitutive	constitutive	JJ	JJ	_	23	amod	_	_
22	GH	gh	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	19	nmod	_	_
24	could	could	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	abolished	abolish	VBN	VBN	_	5	advcl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	presence	presence	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	anti-hGH	anti-hgh	JJ	JJ	_	32	amod	_	_
32	mAb	mab	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	GH-induced	gh-induced	JJ	JJ	_	4	amod	_	_
3	inhibitory	inhibitory	JJ	JJ	_	2	dep	_	_
4	effect	effect	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	normal	normal	JJ	JJ	_	11	amod	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	monocyte-derived	monocyte-derived	JJ	JJ	_	14	amod	_	_
14	macrophages	macrophage	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	7	punct	_	_

1	Inhibition	inhibition	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	TNF-alpha	tnf-alpha	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	THP-1-hGH-transfected	thp-1-hgh-transfected	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	cultured	culture	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	presence	presence	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	LPS	lps	NN	NN	_	11	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	dependent	dependent	JJ	JJ	_	0	root	_	_
16	on	on	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	selective	selective	JJ	JJ	_	19	amod	_	_
19	pathway	pathway	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	since	since	IN	IN	_	28	mark	_	_
22	no	no	DT	DT	_	23	neg	_	_
23	inhibition	inhibition	NN	NN	_	28	nsubjpass	_	_
24	of	of	IN	IN	_	26	case	_	_
25	TNF-alpha	tnf-alpha	NN	NN	_	26	compound	_	_
26	production	production	NN	NN	_	23	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	observed	observe	VBN	VBN	_	15	advcl	_	_
29	when	when	WRB	WRB	_	32	advmod	_	_
30	cells	cell	NNS	NNS	_	32	nsubjpass	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	cultured	culture	VBN	VBN	_	28	advcl	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	presence	presence	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	PMA	pma	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	Inhibition	inhibition	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	TNF-alpha	tnf-alpha	NN	NN	_	4	compound	_	_
4	secretion	secretion	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	8	case	_	_
6	LPS-stimulated	lps-stimulated	JJ	JJ	_	8	amod	_	_
7	THP-1-hGH	thp-1-hgh	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	decrease	decrease	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	translocation	translocation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	factor-kappaB	factor-kappab	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	capacity	capacity	NN	NN	_	24	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GH	gh	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	2	acl	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	9	amod	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	without	without	IN	IN	_	13	mark	_	_
13	altering	alter	VBG	VBG	_	6	advcl	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	pathways	pathway	NNS	NNS	_	13	dobj	_	_
16	leading	lead	VBG	VBG	_	15	acl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	19	compound	_	_
19	production	production	NN	NN	_	16	nmod	_	_
20	may	may	MD	MD	_	24	aux	_	_
21	be	be	VB	VB	_	24	cop	_	_
22	of	of	IN	IN	_	24	case	_	_
23	potential	potential	JJ	JJ	_	24	amod	_	_
24	relevance	relevance	NN	NN	_	0	root	_	_
25	in	in	IN	IN	_	27	case	_	_
26	septic	septic	JJ	JJ	_	27	amod	_	_
27	shock	shock	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	since	since	IN	IN	_	32	mark	_	_
30	GH	gh	NN	NN	_	32	nsubj	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	available	available	JJ	JJ	_	24	advcl	_	_
33	for	for	IN	IN	_	35	case	_	_
34	clinical	clinical	JJ	JJ	_	35	amod	_	_
35	use	use	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	24	punct	_	_

1	Impaired	impaired	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-fos/c-jun	c-fos/c-jun	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	of	of	IN	IN	_	10	case	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	5	conj	_	_
11	binding	bind	VBG	VBG	_	10	acl	_	_
12	distinct	distinct	JJ	JJ	_	15	amod	_	_
13	c-fos/c-jun	c-fos/c-jun	NN	NN	_	15	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	elements	element	NNS	NNS	_	11	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	activated	activate	VBN	VBN	_	20	amod	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	2	nmod	_	_
21	during	during	IN	IN	_	22	case	_	_
22	aging	aging	NN	NN	_	2	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	2	nmod	_	_
6	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	5	dep	_	_
7	AP-1	ap-1	NN	NN	_	6	dep	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	essential	essential	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	14	case	_	_
11	normal	normal	JJ	JJ	_	14	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	responsiveness	responsiveness	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	often	often	RB	RB	_	18	advmod	_	_
18	impaired	impaired	JJ	JJ	_	9	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	during	during	IN	IN	_	23	case	_	_
23	aging	aging	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	investigated	investigate	VBD	VBD	_	0	root	_	_
8	whether	whether	IN	IN	_	22	mark	_	_
9	aberrancies	aberrancy	NNS	NNS	_	22	nsubj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	regulation	regulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	c-fos/c-jun	c-fos/c-jun	NN	NN	_	12	nmod	_	_
15	at	at	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	mRNA	mrna	NN	NN	_	9	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	protein	protein	NN	NN	_	17	conj	_	_
20	level	level	NN	NN	_	17	dep	_	_
21	might	might	MD	MD	_	22	aux	_	_
22	underlie	underlie	VB	VB	_	7	ccomp	_	_
23	the	the	DT	DT	_	25	det	_	_
24	age-associated	age-associated	JJ	JJ	_	25	amod	_	_
25	impairments	impairment	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	AP-1	ap-1	NN	NN	_	25	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	Whereas	whereas	IN	IN	_	22	mark	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	22	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	young	young	JJ	JJ	_	6	amod	_	_
6	subjects	subject	NNS	NNS	_	3	nmod	_	_
7	stimulated	stimulate	VBN	VBN	_	3	acl	_	_
8	with	with	IN	IN	_	11	case	_	_
9	cross-linked	cross-linked	JJ	JJ	_	11	amod	_	_
10	anti-CD3epsilon	anti-cd3epsilon	JJ	JJ	_	11	amod	_	_
11	mAb	mab	NN	NN	_	7	nmod	_	_
12	OKT3	okt3	NN	NN	_	11	dep	_	_
13	plus	plus	CC	CC	_	11	cc	_	_
14	PMA	pma	NN	NN	_	11	conj	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	lectin	lectin	NN	NN	_	11	conj	_	_
19	PHA	pha	NN	NN	_	18	dep	_	_
20	plus	plus	CC	CC	_	18	cc	_	_
21	PMA	pma	NN	NN	_	18	conj	_	_
22	demonstrated	demonstrate	VBD	VBD	_	39	advcl	_	_
23	considerable	considerable	JJ	JJ	_	24	amod	_	_
24	increases	increase	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	c-Fos	c-fos	NN	NN	_	28	compound	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	39	punct	_	_
30	the	the	DT	DT	_	31	det	_	_
31	expression	expression	NN	NN	_	39	nsubjpass	_	_
32	of	of	IN	IN	_	33	case	_	_
33	c-Fos	c-fos	NN	NN	_	31	nmod	_	_
34	but	but	CC	CC	_	35	cc	_	_
35	not	not	RB	RB	_	33	cc	_	_
36	c-Jun	c-jun	NN	NN	_	33	conj	_	_
37	was	be	VBD	VBD	_	39	auxpass	_	_
38	markedly	markedly	RB	RB	_	39	advmod	_	_
39	reduced	reduce	VBN	VBN	_	0	root	_	_
40	in	in	IN	IN	_	43	case	_	_
41	stimulated	stimulate	VBN	VBN	_	43	amod	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	39	nmod	_	_
44	from	from	IN	IN	_	47	case	_	_
45	certain	certain	JJ	JJ	_	47	amod	_	_
46	elderly	elderly	JJ	JJ	_	47	amod	_	_
47	subjects	subject	NNS	NNS	_	43	nmod	_	_
48	.	.	.	.	_	39	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	RNase	rnase	NN	NN	_	6	compound	_	_
5	protection	protection	NN	NN	_	6	compound	_	_
6	assays	assay	NNS	NNS	_	7	nsubj	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	anti-CD3/PMA-stimulated	anti-cd3/pma-stimulated	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	19	nsubj	_	_
12	from	from	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	substantial	substantial	JJ	JJ	_	15	amod	_	_
15	proportion	proportion	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	elderly	elderly	JJ	JJ	_	18	amod	_	_
18	subjects	subject	NNS	NNS	_	15	nmod	_	_
19	exhibited	exhibit	VBD	VBD	_	7	ccomp	_	_
20	decreased	decreased	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	c-fos	c-fos	NN	NN	_	21	nmod	_	_
24	and/or	and/or	CC	CC	_	23	cc	_	_
25	c-jun	c-jun	NN	NN	_	23	conj	_	_
26	mRNA	mrna	NN	NN	_	23	dep	_	_
27	compared	compare	VBN	VBN	_	30	case	_	_
28	to	to	TO	TO	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	19	advcl	_	_
31	from	from	IN	IN	_	33	case	_	_
32	young	young	JJ	JJ	_	33	amod	_	_
33	subjects	subject	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	levels	level	NNS	NNS	_	37	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	8	nmod	_	_
13	recognizing	recognize	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	18	det	_	_
15	AP-1	ap-1	NN	NN	_	18	compound	_	_
16	consensus	consensus	NN	NN	_	18	compound	_	_
17	TRE	tre	NN	NN	_	18	compound	_	_
18	motif	motif	NN	NN	_	13	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	the	the	DT	DT	_	25	det	_	_
21	proximal	proximal	JJ	JJ	_	25	amod	_	_
22	c-jun	c-jun	NN	NN	_	25	compound	_	_
23	TRE-like	tre-like	JJ	JJ	_	25	amod	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	18	conj	_	_
26	,	,	,	,	_	18	punct	_	_
27	and	and	CC	CC	_	18	cc	_	_
28	the	the	DT	DT	_	32	det	_	_
29	c-fos	c-fos	NN	NN	_	32	compound	_	_
30	serum	serum	NN	NN	_	32	compound	_	_
31	response	response	NN	NN	_	32	compound	_	_
32	element	element	NN	NN	_	18	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	SRE	sre	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	were	be	VBD	VBD	_	37	auxpass	_	_
37	determined	determine	VBN	VBN	_	1	parataxis	_	_
38	in	in	IN	IN	_	39	case	_	_
39	resting	rest	VBG	VBG	_	37	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	stimulated	stimulate	VBN	VBN	_	39	conj	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	39	dep	_	_
44	.	.	.	.	_	1	punct	_	_

1	Although	although	IN	IN	_	10	dep	_	_
2	the	the	DT	DT	_	3	det	_	_
3	stimulation	stimulation	NN	NN	_	10	dep	_	_
4	of	of	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	young	young	JJ	JJ	_	9	amod	_	_
9	subjects	subject	NNS	NNS	_	6	nmod	_	_
10	resulted	result	VBD	VBD	_	41	advcl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	coordinated	coordinate	VBN	VBN	_	13	amod	_	_
13	increases	increase	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	complexes	complex	NNS	NNS	_	13	nmod	_	_
18	binding	bind	VBG	VBG	_	17	acl	_	_
19	the	the	DT	DT	_	21	dep	_	_
20	AP-1	ap-1	NN	NN	_	21	compound	_	_
21	TRE	tre	NN	NN	_	18	dobj	_	_
22	,	,	,	,	_	21	punct	_	_
23	c-jun	c-jun	NN	NN	_	24	compound	_	_
24	TRE	tre	NN	NN	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	c-fos	c-fos	NN	NN	_	31	compound	_	_
28	SRE	sre	NN	NN	_	31	compound	_	_
29	DNA	dna	NN	NN	_	31	compound	_	_
30	sequence	sequence	NN	NN	_	31	compound	_	_
31	motifs	motif	NNS	NNS	_	21	conj	_	_
32	,	,	,	,	_	41	punct	_	_
33	age-related	age-related	JJ	JJ	_	34	amod	_	_
34	reductions	reduction	NNS	NNS	_	41	nsubjpass	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	activation	activation	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	AP-1	ap-1	NN	NN	_	37	nmod	_	_
40	were	be	VBD	VBD	_	41	auxpass	_	_
41	accompanied	accompany	VBN	VBN	_	0	root	_	_
42	by	by	IN	IN	_	44	case	_	_
43	decreased	decrease	VBN	VBN	_	44	amod	_	_
44	levels	level	NNS	NNS	_	41	nmod	_	_
45	of	of	IN	IN	_	47	case	_	_
46	c-jun	c-jun	NN	NN	_	47	compound	_	_
47	TRE	tre	NN	NN	_	44	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	c-fos	c-fos	NN	NN	_	50	compound	_	_
50	SRE	sre	NN	NN	_	47	conj	_	_
51	binding	binding	NN	NN	_	52	compound	_	_
52	complexes	complex	NNS	NNS	_	47	dep	_	_
53	.	.	.	.	_	41	punct	_	_

1	Furthermore	furthermore	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	complexes	complex	NNS	NNS	_	21	nsubj	_	_
7	binding	bind	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	SRE	sre	NN	NN	_	10	compound	_	_
10	motif	motif	NN	NN	_	7	dobj	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	young	young	JJ	JJ	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	elderly	elderly	JJ	JJ	_	17	conj	_	_
20	subjects	subject	NNS	NNS	_	17	dep	_	_
21	contained	contain	VBD	VBD	_	0	root	_	_
22	serum	serum	NN	NN	_	24	compound	_	_
23	response	response	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	21	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Elk-1	elk-1	NN	NN	_	24	conj	_	_
27	pointing	point	VBG	VBG	_	24	acl	_	_
28	toward	toward	IN	IN	_	30	case	_	_
29	age-related	age-related	JJ	JJ	_	30	amod	_	_
30	defects	defect	NNS	NNS	_	27	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	activation	activation	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	transcriptional	transcriptional	JJ	JJ	_	37	amod	_	_
36	regulatory	regulatory	JJ	JJ	_	37	amod	_	_
37	proteins	protein	NNS	NNS	_	33	nmod	_	_
38	distinct	distinct	JJ	JJ	_	37	amod	_	_
39	from	from	IN	IN	_	40	case	_	_
40	c-jun/AP-1	c-jun/ap-1	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	underlying	underlie	VBG	VBG	_	6	amod	_	_
6	aberrancies	aberrancy	NNS	NNS	_	20	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-fos/c-jun	c-fos/c-jun	NN	NN	_	9	nmod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
16	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	11	conj	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	contribute	contribute	VB	VB	_	3	ccomp	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	age-related	age-related	JJ	JJ	_	24	amod	_	_
24	impairments	impairment	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	AP-1	ap-1	NN	NN	_	27	compound	_	_
27	activation	activation	NN	NN	_	24	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Dissociation	dissociation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	Jak	jak	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	pathway	pathway	NN	NN	_	1	nmod	_	_
7	from	from	IN	IN	_	10	case	_	_
8	G-CSF	g-csf	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	signaling	signaling	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	neutrophils	neutrophil	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Activation	activation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	granulocyte	granulocyte	NN	NN	_	7	compound	_	_
5	colony-stimulating	colony-stimulating	JJ	JJ	_	7	amod	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	G-CSFR	g-csfr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	rapid	rapid	JJ	JJ	_	14	amod	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	multiple	multiple	JJ	JJ	_	18	amod	_	_
17	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
18	substrates	substrate	NNS	NNS	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	proliferating	proliferate	VBG	VBG	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	11	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	nonproliferating	nonproliferating	JJ	JJ	_	27	amod	_	_
24	,	,	,	,	_	27	punct	_	_
25	terminally	terminally	RB	RB	_	27	advmod	_	_
26	differentiated	differentiate	VBN	VBN	_	27	amod	_	_
27	neutrophils	neutrophil	NNS	NNS	_	21	conj	_	_
28	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinases	kinase	NNS	NNS	_	24	nsubj	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	couple	couple	VBP	VBP	_	2	acl:relcl	_	_
5	ligand	ligand	NN	NN	_	4	dobj	_	_
6	binding	bind	VBG	VBG	_	5	amod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	substrates	substrate	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	G-CSFR	g-csfr	NN	NN	_	9	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	4	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	specific	specific	JJ	JJ	_	21	amod	_	_
20	functional	functional	JJ	JJ	_	19	dep	_	_
21	programs	program	NNS	NNS	_	17	nmod	_	_
22	are	be	VBP	VBP	_	24	cop	_	_
23	largely	largely	RB	RB	_	24	advmod	_	_
24	unknown	unknown	JJ	JJ	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	early	early	JJ	JJ	_	9	amod	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	events	event	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	proliferating	proliferate	VBG	VBG	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	terminally	terminally	RB	RB	_	15	advmod	_	_
14	differentiated	differentiate	VBN	VBN	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	conj	_	_
16	following	follow	VBG	VBG	_	18	case	_	_
17	G-CSF	g-csf	NN	NN	_	18	compound	_	_
18	stimulation	stimulation	NN	NN	_	9	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	determine	determine	VB	VB	_	6	advcl	_	_
21	whether	whether	IN	IN	_	26	mark	_	_
22	identical	identical	JJ	JJ	_	24	amod	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	cascades	cascade	NNS	NNS	_	26	nsubjpass	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	activated	activate	VBN	VBN	_	20	ccomp	_	_
27	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	murine	murine	JJ	JJ	_	4	amod	_	_
3	Ba/F3	ba/f3	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	20	nmod	_	_
5	transfected	transfect	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	G-CSFR	g-csfr	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NFS-60	nfs-60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	constitutively	constitutively	RB	RB	_	14	advmod	_	_
14	expressing	express	VBG	VBG	_	9	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	murine	murine	JJ	JJ	_	17	amod	_	_
17	G-CSFR	g-csfr	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	20	punct	_	_
19	G-CSF	g-csf	NN	NN	_	20	nsubj	_	_
20	induced	induce	VBD	VBD	_	0	root	_	_
21	tyrosine	tyrosine	NN	NN	_	22	compound	_	_
22	phosphorylation	phosphorylation	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	activation	activation	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	Jak1	jak1	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	Jak2	jak2	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	Tyk2	tyk2	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	20	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Stat3	stat3	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	,	,	,	,	_	4	punct	_	_
7	to	to	TO	TO	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	lesser	lesser	JJR	JJR	_	10	amod	_	_
10	extent	extent	NN	NN	_	4	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	Stat1	stat1	NN	NN	_	4	conj	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	detected	detect	VBN	VBN	_	0	root	_	_
16	following	follow	VBG	VBG	_	18	case	_	_
17	G-CSF	g-csf	NN	NN	_	18	compound	_	_
18	stimulation	stimulation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	7	det	_	_
3	mitogenically	mitogenically	RB	RB	_	7	advmod	_	_
4	incompetent	incompetent	JJ	JJ	_	7	amod	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	G-CSFR	g-csfr	NN	NN	_	7	compound	_	_
7	mutant	mutant	NN	NN	_	1	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	14	nmod	_	_
10	Pro639	pro639	NN	NN	_	14	nsubjpass	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Pro641	pro641	NN	NN	_	10	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	substituted	substitute	VBN	VBN	_	7	acl:relcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	alanine	alanine	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	1	punct	_	_
18	the	the	DT	DT	_	22	det	_	_
19	box	box	NN	NN	_	22	compound	_	_
20	1	1	CD	CD	_	22	nummod	_	_
21	PDP	pdp	NN	NN	_	22	compound	_	_
22	motif	motif	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	found	find	VBN	VBN	_	1	parataxis	_	_
25	to	to	TO	TO	_	27	mark	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	required	require	VBN	VBN	_	24	xcomp	_	_
28	for	for	IN	IN	_	29	case	_	_
29	activation	activation	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	Jak	jak	NN	NN	_	32	compound	_	_
32	kinases	kinase	NNS	NNS	_	29	nmod	_	_
33	,	,	,	,	_	29	punct	_	_
34	tyrosine	tyrosine	NN	NN	_	35	compound	_	_
35	phosphorylation	phosphorylation	NN	NN	_	29	conj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	G-CSFR	g-csfr	NN	NN	_	35	nmod	_	_
39	,	,	,	,	_	29	punct	_	_
40	and	and	CC	CC	_	29	cc	_	_
41	recruitment	recruitment	NN	NN	_	29	conj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	Stat	stat	NN	NN	_	44	compound	_	_
44	proteins	protein	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	1	punct	_	_

1	Notably	notably	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	activation	activation	NN	NN	_	17	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Jak1	jak1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	Jak2	jak2	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	Tyk2	tyk2	NN	NN	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	Stat1	stat1	NN	NN	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	or	or	CC	CC	_	6	cc	_	_
15	Stat3	stat3	NN	NN	_	6	conj	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	observed	observe	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	neutrophils	neutrophil	NNS	NNS	_	17	nmod	_	_
20	following	follow	VBG	VBG	_	22	case	_	_
21	G-CSF	g-csf	NN	NN	_	22	compound	_	_
22	stimulation	stimulation	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	8	neg	_	_
7	detectable	detectable	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	5	nsubj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	neutrophils	neutrophil	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	recently	recently	RB	RB	_	14	advmod	_	_
14	cloned	clone	VBN	VBN	_	16	amod	_	_
15	Jak3	jak3	NN	NN	_	16	compound	_	_
16	kinase	kinase	NN	NN	_	8	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	21	nsubjpass	_	_
19	has	have	VBZ	VBZ	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	reported	report	VBN	VBN	_	16	acl:relcl	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	expressed	express	VBN	VBN	_	21	xcomp	_	_
25	at	at	IN	IN	_	27	case	_	_
26	high	high	JJ	JJ	_	27	amod	_	_
27	levels	level	NNS	NNS	_	24	nmod	_	_
28	as	as	IN	IN	_	31	mark	_	_
29	myeloid	myeloid	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	31	nsubj	_	_
31	undergo	undergo	VBP	VBP	_	21	advcl	_	_
32	terminal	terminal	JJ	JJ	_	34	amod	_	_
33	neutrophilic	neutrophilic	JJ	JJ	_	32	dep	_	_
34	maturation	maturation	NN	NN	_	31	dobj	_	_
35	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	lack	lack	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	involvement	involvement	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Jak	jak	NN	NN	_	10	compound	_	_
10	kinases	kinase	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	signaling	signaling	NN	NN	_	7	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	G-CSFR	g-csfr	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	suggest	suggest	VBP	VBP	_	3	conj	_	_
21	utilization	utilization	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	alternative	alternative	JJ	JJ	_	26	amod	_	_
24	signal	signal	NN	NN	_	26	compound	_	_
25	transduction	transduction	NN	NN	_	26	compound	_	_
26	pathways	pathway	NNS	NNS	_	21	nmod	_	_
27	distinct	distinct	JJ	JJ	_	26	amod	_	_
28	from	from	IN	IN	_	29	case	_	_
29	those	those	DT	DT	_	27	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	proliferating	proliferate	VBG	VBG	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Jak-Stat	jak-stat	JJ	JJ	_	5	amod	_	_
5	pathway	pathway	NN	NN	_	1	nmod	_	_
6	correlates	correlate	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	proliferative	proliferative	JJ	JJ	_	9	amod	_	_
9	signaling	signaling	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	G-CSFR	g-csfr	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	requires	require	VBZ	VBZ	_	6	conj	_	_
15	the	the	DT	DT	_	20	det	_	_
16	membrane-proximal	membrane-proximal	JJ	JJ	_	20	amod	_	_
17	box	box	NN	NN	_	20	compound	_	_
18	1	1	CD	CD	_	20	nummod	_	_
19	PXP	pxp	NN	NN	_	20	compound	_	_
20	motif	motif	NN	NN	_	14	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	conserved	conserve	VBN	VBN	_	20	acl:relcl	_	_
25	in	in	IN	IN	_	26	case	_	_
26	members	member	NNS	NNS	_	24	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	cytokine	cytokine	NN	NN	_	31	compound	_	_
30	receptor	receptor	NN	NN	_	31	compound	_	_
31	superfamily	superfamily	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Adenovirus	adenovirus	NN	NN	_	4	compound	_	_
2	E1B	e1b	NN	NN	_	4	compound	_	_
3	19K	19k	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	efficient	efficient	JJ	JJ	_	10	amod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	U937	u937	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	adenovirus	adenovirus	NN	NN	_	5	compound	_	_
3	E1B	e1b	NN	NN	_	5	compound	_	_
4	19K	19k	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	essential	essential	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	transformation	transformation	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	primary	primary	JJ	JJ	_	15	amod	_	_
14	rodent	rodent	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	cooperation	cooperation	NN	NN	_	11	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	E1A	e1a	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	inhibition	inhibition	NN	NN	_	11	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	apoptosis	apoptosis	NN	NN	_	23	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	lytic	lytic	JJ	JJ	_	28	amod	_	_
28	infection	infection	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	this	this	DT	DT	_	9	det	_	_
7	E1B	e1b	NN	NN	_	9	compound	_	_
8	19K	19k	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	necessary	necessary	JJ	JJ	_	4	ccomp	_	_
13	for	for	IN	IN	_	16	case	_	_
14	viral	viral	JJ	JJ	_	16	amod	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	such	such	JJ	JJ	_	24	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	HeLa	hela	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	KB	kb	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	reported	report	VBD	VBD	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	E1B	e1b	NN	NN	_	7	compound	_	_
7	19K	19k	NN	NN	_	9	compound	_	_
8	mutant	mutant	JJ	JJ	_	9	amod	_	_
9	viruses	virus	NNS	NNS	_	11	nsubj	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	unable	unable	JJ	JJ	_	2	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	replicate	replicate	VB	VB	_	11	xcomp	_	_
14	efficiently	efficiently	RB	RB	_	13	advmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	monocyte	monocyte	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	U937	u937	NN	NN	_	19	appos	_	_
22	.	.	.	.	_	2	punct	_	_

1	Viral	viral	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	synthesis	synthesis	NN	NN	_	9	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	late	late	JJ	JJ	_	7	amod	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	defective	defective	JJ	JJ	_	9	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	U937	u937	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	infected	infect	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	E1B	e1b	NN	NN	_	19	compound	_	_
19	19K	19k	NN	NN	_	20	compound	_	_
20	mutants	mutant	NNS	NNS	_	16	nmod	_	_
21	compared	compare	VBN	VBN	_	24	case	_	_
22	with	with	IN	IN	_	24	case	_	_
23	wild-type	wild-type	JJ	JJ	_	24	amod	_	_
24	virus	virus	NN	NN	_	12	advcl	_	_
25	.	.	.	.	_	9	punct	_	_

1	Early	early	RB	RB	_	5	amod	_	_
2	viral	viral	JJ	JJ	_	1	dep	_	_
3	RNA	rna	NN	NN	_	5	compound	_	_
4	splicing	splicing	NN	NN	_	5	compound	_	_
5	patterns	pattern	NNS	NNS	_	7	nsubj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	differ	differ	VBP	VBP	_	0	root	_	_
8	between	between	IN	IN	_	9	case	_	_
9	wild-type	wild-type	JJ	JJ	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	dl337-infected	dl337-infected	JJ	JJ	_	9	conj	_	_
12	cells	cell	NNS	NNS	_	9	dep	_	_
13	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	defect	defect	NN	NN	_	10	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	viral	viral	JJ	JJ	_	7	amod	_	_
7	replication	replication	NN	NN	_	4	nmod	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	complemented	complement	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	dl312	dl312	NN	NN	_	13	compound	_	_
13	virus	virus	NN	NN	_	10	nmod	_	_
14	defective	defective	JJ	JJ	_	13	amod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	E1A	e1a	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	4	4	CD	CD	_	19	nummod	_	_
19	days	day	NNS	NNS	_	10	nmod	_	_
20	after	after	IN	IN	_	19	case	_	_
21	infection	infection	NN	NN	_	19	dep	_	_
22	with	with	IN	IN	_	24	case	_	_
23	E1B	e1b	NN	NN	_	24	compound	_	_
24	mutants	mutant	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	10	punct	_	_
26	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
27	persistence	persistence	NN	NN	_	26	dobj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	E1B	e1b	NN	NN	_	32	compound	_	_
31	mutant	mutant	JJ	JJ	_	32	amod	_	_
32	genome	genome	NN	NN	_	27	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	infected	infected	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	32	nmod	_	_
37	despite	despite	IN	IN	_	39	case	_	_
38	defective	defective	JJ	JJ	_	39	amod	_	_
39	onset	onset	NN	NN	_	27	nmod	_	_
40	of	of	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	late	late	JJ	JJ	_	43	amod	_	_
43	phase	phase	NN	NN	_	39	nmod	_	_
44	of	of	IN	IN	_	45	case	_	_
45	replication	replication	NN	NN	_	43	nmod	_	_
46	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	E1B	e1b	NN	NN	_	6	compound	_	_
6	19K	19k	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	3	ccomp	_	_
9	for	for	IN	IN	_	13	case	_	_
10	efficient	efficient	JJ	JJ	_	13	amod	_	_
11	viral	viral	JJ	JJ	_	10	dep	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	replication	replication	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	U937	u937	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Inefficient	inefficient	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	replication	replication	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	another	another	DT	DT	_	11	det	_	_
9	monocyte	monocyte	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	THP-1	thp-1	NN	NN	_	11	appos	_	_
14	.	.	.	.	_	6	punct	_	_

1	Interaction	interaction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	RFX1	rfx1	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	MIBP1	mibp1	NN	NN	_	5	conj	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	gamma	gamma	NN	NN	_	11	compound	_	_
11	motif	motif	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	negative	negative	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	hepatitis	hepatitis	NN	NN	_	23	compound	_	_
20	B	b	NN	NN	_	23	compound	_	_
21	virus	virus	NN	NN	_	23	compound	_	_
22	core	core	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	negative	negative	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	18	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NRE	nre	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	of	of	IN	IN	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	hepatitis	hepatitis	NN	NN	_	17	compound	_	_
11	B	b	NN	NN	_	17	compound	_	_
12	virus	virus	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	HBV	hbv	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	core	core	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	4	nmod	_	_
18	contains	contain	VBZ	VBZ	_	0	root	_	_
19	three	three	CD	CD	_	20	nummod	_	_
20	subregions	subregion	NNS	NNS	_	18	dobj	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	act	act	VBP	VBP	_	20	acl:relcl	_	_
23	synergistically	synergistically	RB	RB	_	22	advmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	suppress	suppress	VB	VB	_	22	xcomp	_	_
26	core	core	NN	NN	_	28	compound	_	_
27	promoter	promoter	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	25	dobj	_	_
29	.	.	.	.	_	18	punct	_	_

1	One	one	CD	CD	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	subregions	subregion	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	NRE	nre	NN	NN	_	7	compound	_	_
7	gamma	gamma	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	1	punct	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	active	active	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	16	case	_	_
12	both	both	CC	CC	_	16	cc:preconj	_	_
13	HeLa	hela	NN	NN	_	16	compound	_	_
14	cervical	cervical	JJ	JJ	_	16	amod	_	_
15	carcinoma	carcinoma	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Huh7	huh7	NN	NN	_	20	compound	_	_
19	hepatoma	hepatoma	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	conj	_	_
21	and	and	CC	CC	_	10	cc	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	found	find	VBN	VBN	_	10	conj	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	bound	bind	VBN	VBN	_	23	xcomp	_	_
27	by	by	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	factor	factor	NN	NN	_	26	nmod	_	_
31	present	present	JJ	JJ	_	30	amod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	both	both	DT	DT	_	35	det	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	types	type	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	10	nsubj	_	_
8	RFX1	rfx1	NN	NN	_	7	dep	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	bind	bind	VB	VB	_	3	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	NRE	nre	NN	NN	_	13	compound	_	_
13	gamma	gamma	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	transactivate	transactivate	VB	VB	_	10	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	core	core	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	15	dobj	_	_
19	through	through	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	site	site	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Mutations	mutation	NNS	NNS	_	10	nsubj	_	_
2	which	which	WDT	WDT	_	3	nsubj	_	_
3	abrogated	abrogate	VBD	VBD	_	1	acl:relcl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	gene-suppressive	gene-suppressive	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NRE	nre	NN	NN	_	9	compound	_	_
9	gamma	gamma	NN	NN	_	6	nmod	_	_
10	prevented	prevent	VBD	VBD	_	0	root	_	_
11	RFX1	rfx1	NN	NN	_	10	dobj	_	_
12	from	from	IN	IN	_	13	case	_	_
13	binding	binding	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	NRE	nre	NN	NN	_	16	compound	_	_
16	gamma	gamma	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	RFX1	rfx1	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	bind	bind	VB	VB	_	0	root	_	_
7	simultaneously	simultaneously	RB	RB	_	6	advmod	_	_
8	,	,	,	,	_	6	punct	_	_
9	most	most	RBS	RBS	_	10	advmod	_	_
10	likely	likely	JJ	JJ	_	13	advmod	_	_
11	as	as	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	heterodimer	heterodimer	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	6	nmod	_	_
19	MIBP1	mibp1	NN	NN	_	18	dep	_	_
20	to	to	TO	TO	_	22	case	_	_
21	NRE	nre	NN	NN	_	22	compound	_	_
22	gamma	gamma	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	14	nmod	_	_
4	of	of	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	cloned	clone	VBN	VBN	_	8	amod	_	_
7	MIBP1	mibp1	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	further	further	JJ	JJ	_	11	amod	_	_
11	studies	study	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	hypothesize	hypothesize	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	RFX1	rfx1	NN	NN	_	17	nsubj	_	_
17	acts	act	VBZ	VBZ	_	14	ccomp	_	_
18	with	with	IN	IN	_	19	case	_	_
19	MIBP1	mibp1	NN	NN	_	17	nmod	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	negatively	negatively	RB	RB	_	22	advmod	_	_
22	regulate	regulate	VB	VB	_	17	xcomp	_	_
23	the	the	DT	DT	_	26	det	_	_
24	core	core	NN	NN	_	26	compound	_	_
25	promoter	promoter	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	22	dobj	_	_
27	through	through	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	NRE	nre	NN	NN	_	31	compound	_	_
30	gamma	gamma	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	22	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	RFX1	rfx1	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	transactivate	transactivate	VB	VB	_	2	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	core	core	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	6	dobj	_	_
10	raises	raise	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	possibility	possibility	NN	NN	_	10	dobj	_	_
13	that	that	IN	IN	_	16	mark	_	_
14	RFX1	rfx1	NN	NN	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	play	play	VB	VB	_	12	ccomp	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dual	dual	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	regulating	regulate	VBG	VBG	_	16	advcl	_	_
22	HBV	hbv	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	10	punct	_	_

1	Evaluation	evaluation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	monoclonal	monoclonal	JJ	JJ	_	5	amod	_	_
4	anti-D	anti-d	JJ	JJ	_	5	amod	_	_
5	reagents	reagent	NNS	NNS	_	1	nmod	_	_
6	using	use	VBG	VBG	_	1	acl	_	_
7	D	d	NN	NN	_	9	compound	_	_
8	variant	variant	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	dobj	_	_
10	.	.	.	.	_	1	punct	_	_

1	Monoclonal	monoclonal	JJ	JJ	_	3	amod	_	_
2	anti-D	anti-d	JJ	JJ	_	3	amod	_	_
3	antibodies	antibody	NNS	NNS	_	12	nsubjpass	_	_
4	submitted	submit	VBN	VBN	_	3	acl	_	_
5	to	to	TO	TO	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	Third	Third	NNP	NNP	_	10	compound	_	_
8	Monoclonal	Monoclonal	NNP	NNP	_	10	compound	_	_
9	International	International	NNP	NNP	_	10	compound	_	_
10	Workshop	Workshop	NNP	NNP	_	4	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	evaluated	evaluate	VBN	VBN	_	0	root	_	_
13	against	against	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	number	number	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	D	d	NN	NN	_	19	compound	_	_
18	variant	variant	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	using	use	VBG	VBG	_	12	xcomp	_	_
21	standard	standard	JJ	JJ	_	23	amod	_	_
22	serological	serological	JJ	JJ	_	21	dep	_	_
23	techniques	technique	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	monoclonal	monoclonal	JJ	JJ	_	3	amod	_	_
3	antibodies	antibody	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	discriminate	discriminate	VB	VB	_	5	xcomp	_	_
8	between	between	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Categories	category	NNS	NNS	_	10	nmod	_	_
13	Va	va	NN	NN	_	12	dep	_	_
14	,	,	,	,	_	12	punct	_	_
15	VI	vi	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	DFR	dfr	NN	NN	_	12	conj	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	10	cc	_	_
20	Category	category	NN	NN	_	22	compound	_	_
21	III	iii	CD	CD	_	22	nummod	_	_
22	cells	cell	NNS	NNS	_	10	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Cells	cell	NNS	NNS	_	7	nsubj	_	_
2	within	within	IN	IN	_	4	case	_	_
3	each	each	DT	DT	_	4	det	_	_
4	category	category	NN	NN	_	1	nmod	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	give	give	VB	VB	_	0	root	_	_
8	any	any	DT	DT	_	10	det	_	_
9	aberrant	aberrant	JJ	JJ	_	10	amod	_	_
10	results	result	NNS	NNS	_	7	dobj	_	_
11	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Rh	rh	NN	NN	_	5	compound	_	_
3	:	:	:	:	_	5	punct	_	_
4	33	33	CD	CD	_	5	nummod	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	behaved	behave	VBD	VBD	_	0	root	_	_
7	as	as	IN	IN	_	14	case	_	_
8	normal	normal	JJ	JJ	_	14	amod	_	_
9	Rh	rh	NN	NN	_	14	compound	_	_
10	(	(	-LRB-	-LRB-	_	14	punct	_	_
11	D	d	NN	NN	_	14	compound	_	_
12	)	)	-RRB-	-RRB-	_	14	punct	_	_
13	positive	positive	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Pancreatic	pancreatic	JJ	JJ	_	2	amod	_	_
2	development	development	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	maturation	maturation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	islet	islet	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cell	cell	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Studies	study	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	pluripotent	pluripotent	JJ	JJ	_	5	amod	_	_
4	islet	islet	NN	NN	_	5	compound	_	_
5	cultures	culture	NNS	NNS	_	1	nmod	_	_
6	.	.	.	.	_	1	punct	_	_

1	Pancreas	pancreas	NN	NN	_	2	compound	_	_
2	organogenesis	organogenesis	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	highly	highly	RB	RB	_	6	advmod	_	_
6	regulated	regulate	VBN	VBN	_	7	amod	_	_
7	process	process	NN	NN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	in	in	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	13	nmod	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	anlage	anlage	NNS	NNS	_	13	nsubj	_	_
13	evaginate	evaginate	VBP	VBP	_	7	acl:relcl	_	_
14	from	from	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	primitive	primitive	JJ	JJ	_	17	amod	_	_
17	gut	gut	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	later	later	RB	RB	_	3	advmod	_	_
3	fuse	fuse	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	,	,	,	,	_	3	punct	_	_
7	under	under	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	influence	influence	NN	NN	_	18	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	surrounding	surround	VBG	VBG	_	13	amod	_	_
13	mesenchyme	mesenchyme	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	the	the	DT	DT	_	17	det	_	_
16	mature	mature	JJ	JJ	_	17	amod	_	_
17	organ	organ	NN	NN	_	18	nsubj	_	_
18	develops	develop	VBZ	VBZ	_	3	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	being	be	VBG	VBG	_	22	auxpass	_	_
21	mainly	mainly	RB	RB	_	22	advmod	_	_
22	composed	compose	VBN	VBN	_	18	xcomp	_	_
23	of	of	IN	IN	_	29	case	_	_
24	ductal	ductal	JJ	JJ	_	29	amod	_	_
25	,	,	,	,	_	24	punct	_	_
26	exocrine	exocrine	JJ	JJ	_	24	conj	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	endocrine	endocrine	JJ	JJ	_	24	conj	_	_
29	compartments	compartment	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Early	early	JJ	JJ	_	2	amod	_	_
2	buds	bud	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	branching	branch	VBG	VBG	_	8	amod	_	_
8	morphogenesis	morphogenesis	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ductal	ductal	JJ	JJ	_	12	amod	_	_
12	epithelium	epithelium	NN	NN	_	8	nmod	_	_
13	from	from	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	20	nmod	_	_
15	endocrine	endocrine	JJ	JJ	_	19	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	exocrine	exocrine	JJ	JJ	_	15	conj	_	_
18	precursor	precursor	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	20	nsubj	_	_
20	bud	bud	VBP	VBP	_	12	acl:relcl	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	eventually	eventually	RB	RB	_	23	advmod	_	_
23	form	form	VB	VB	_	20	xcomp	_	_
24	the	the	DT	DT	_	27	det	_	_
25	two	two	CD	CD	_	27	nummod	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	compartments	compartment	NNS	NNS	_	23	dobj	_	_
28	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	compartments	compartment	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	thought	think	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	11	mark	_	_
7	be	be	VB	VB	_	11	cop	_	_
8	of	of	IN	IN	_	11	case	_	_
9	common	common	JJ	JJ	_	11	amod	_	_
10	endodermal	endodermal	JJ	JJ	_	11	amod	_	_
11	origin	origin	NN	NN	_	5	xcomp	_	_
12	;	;	:	:	_	11	punct	_	_
13	in	in	IN	IN	_	17	case	_	_
14	contrast	contrast	NN	NN	_	17	dep	_	_
15	to	to	TO	TO	_	17	case	_	_
16	earlier	earlier	JJR	JJR	_	17	amod	_	_
17	hypotheses	hypothesis	NNS	NNS	_	11	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	suggested	suggest	VBD	VBD	_	17	acl:relcl	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	endocrine	endocrine	JJ	JJ	_	24	amod	_	_
24	compartment	compartment	NN	NN	_	28	nsubj	_	_
25	was	be	VBD	VBD	_	28	cop	_	_
26	of	of	IN	IN	_	28	case	_	_
27	neuroectodermal	neuroectodermal	JJ	JJ	_	28	amod	_	_
28	origin	origin	NN	NN	_	20	ccomp	_	_
29	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	5	auxpass	_	_
3	thus	thus	RB	RB	_	5	advmod	_	_
4	generally	generally	RB	RB	_	5	advmod	_	_
5	believed	believe	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	pancreatic	pancreatic	JJ	JJ	_	9	amod	_	_
9	endocrine-lineage	endocrine-lineage	NN	NN	_	10	nsubj	_	_
10	possesses	possess	VBZ	VBZ	_	5	ccomp	_	_
11	the	the	DT	DT	_	12	det	_	_
12	ability	ability	NN	NN	_	10	dobj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	mature	mature	VB	VB	_	12	acl	_	_
15	along	along	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	differentiation	differentiation	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	14	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	shares	share	VBZ	VBZ	_	18	acl:relcl	_	_
21	many	many	JJ	JJ	_	22	amod	_	_
22	characteristics	characteristic	NNS	NNS	_	20	dobj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	those	those	DT	DT	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	neuronal	neuronal	JJ	JJ	_	27	amod	_	_
27	differentiation	differentiation	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	years	year	NNS	NNS	_	22	nmod	_	_
4	,	,	,	,	_	22	punct	_	_
5	studies	study	NNS	NNS	_	22	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	insulin-gene	insulin-gene	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	,	,	,	,	_	8	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	particular	particular	JJ	JJ	_	17	nmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	the	the	DT	DT	_	17	det	_	_
15	tissue-specific	tissue-specific	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	control	control	NN	NN	_	8	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	insulin-gene	insulin-gene	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	have	have	VBP	VBP	_	22	aux	_	_
22	provided	provide	VBN	VBN	_	0	root	_	_
23	information	information	NN	NN	_	22	dobj	_	_
24	on	on	IN	IN	_	26	case	_	_
25	pancreas	pancreas	NN	NN	_	26	compound	_	_
26	development	development	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	general	general	JJ	JJ	_	23	nmod	_	_
29	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	review	review	NN	NN	_	4	nsubj	_	_
4	summarizes	summarize	VBZ	VBZ	_	0	root	_	_
5	these	these	DT	DT	_	6	det	_	_
6	findings	finding	NNS	NNS	_	4	dobj	_	_
7	,	,	,	,	_	4	punct	_	_
8	with	with	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	special	special	JJ	JJ	_	11	amod	_	_
11	focus	focus	NN	NN	_	4	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	our	we	PRP$	PRP$	_	15	nmod:poss	_	_
14	own	own	JJ	JJ	_	15	amod	_	_
15	studies	study	NNS	NNS	_	11	nmod	_	_
16	on	on	IN	IN	_	19	case	_	_
17	pluripotent	pluripotent	JJ	JJ	_	19	amod	_	_
18	endocrine	endocrine	JJ	JJ	_	19	amod	_	_
19	cultures	culture	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	rat	rat	NN	NN	_	22	compound	_	_
22	pancreas	pancreas	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	vascular	vascular	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	adhesion	adhesion	NN	NN	_	6	compound	_	_
6	molecule-1	molecule-1	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	low-density	low-density	JJ	JJ	_	9	amod	_	_
9	lipoprotein	lipoprotein	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Low-density	low-density	JJ	JJ	_	2	amod	_	_
2	lipoprotein	lipoprotein	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	LDL	ldl	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	well-established	well-established	JJ	JJ	_	10	amod	_	_
9	risk	risk	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	atherosclerosis	atherosclerosis	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	endothelial	endothelial	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	incubated	incubate	VBN	VBN	_	16	advcl	_	_
6	with	with	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	lipoprotein	lipoprotein	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	pathophysiologic	pathophysiologic	JJ	JJ	_	11	amod	_	_
11	amounts	amount	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	activated	activate	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Among	among	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	documented	document	VBN	VBN	_	5	amod	_	_
4	cellular	cellular	JJ	JJ	_	5	amod	_	_
5	responses	response	NNS	NNS	_	8	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	LDL	ldl	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	0	root	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	recruitment	recruitment	NN	NN	_	8	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	believed	believe	VBN	VBN	_	12	acl:relcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	play	play	VB	VB	_	16	xcomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	major	major	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	23	mark	_	_
23	promoting	promote	VBG	VBG	_	18	advcl	_	_
24	intimal	intimal	JJ	JJ	_	26	amod	_	_
25	plaque	plaque	NN	NN	_	26	compound	_	_
26	formation	formation	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	5	nsubj	_	_
3	presented	present	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	link	link	VB	VB	_	0	root	_	_
6	an	a	DT	DT	_	8	det	_	_
7	atheogenic	atheogenic	JJ	JJ	_	8	amod	_	_
8	lipoprotein	lipoprotein	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	LDL	ldl	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	8	punct	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	5	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecule	molecule	NN	NN	_	14	nmod	_	_
19	important	important	JJ	JJ	_	18	amod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	atherogenesis	atherogenesis	NN	NN	_	19	nmod	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	LDL	ldl	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	vascular	vascular	JJ	JJ	_	8	amod	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	adhesion	adhesion	NN	NN	_	8	compound	_	_
8	molecule-1	molecule-1	NN	NN	_	3	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VCAM-1	vcam-1	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	transcriptionally	transcriptionally	RB	RB	_	3	advmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	increase	increase	NN	NN	_	3	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	15	nmod	_	_
19	through	through	IN	IN	_	20	case	_	_
20	activation	activation	NN	NN	_	3	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	VCAM	vcam	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	blocked	block	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	anti-VCAM	anti-vcam	JJ	JJ	_	7	amod	_	_
7	antibodies	antibody	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	2-day	2-day	JJ	JJ	_	4	amod	_	_
4	incubation	incubation	NN	NN	_	27	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	LDL	ldl	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	27	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	binding	binding	NN	NN	_	27	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	believed	believe	VBN	VBN	_	12	acl:relcl	_	_
17	to	to	TO	TO	_	22	mark	_	_
18	be	be	VB	VB	_	22	cop	_	_
19	a	a	DT	DT	_	22	det	_	_
20	key	key	JJ	JJ	_	22	amod	_	_
21	oxidative-stress	oxidative-stress	JJ	JJ	_	22	amod	_	_
22	sensor	sensor	NN	NN	_	16	xcomp	_	_
23	for	for	IN	IN	_	25	case	_	_
24	VCAM	vcam	NN	NN	_	25	compound	_	_
25	regulation	regulation	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	12	punct	_	_
27	remains	remain	VBZ	VBZ	_	0	root	_	_
28	at	at	IN	IN	_	30	case	_	_
29	basal	basal	JJ	JJ	_	30	amod	_	_
30	level	level	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	27	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activities	activity	NNS	NNS	_	18	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	AP-1	ap-1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GATA	gata	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	18	punct	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	hand	hand	NN	NN	_	18	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	increased	increase	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	20	case	_	_
20	LDL	ldl	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	18	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	component	component	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	LDL-enhanced	ldl-enhanced	JJ	JJ	_	8	amod	_	_
7	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
8	recruitment	recruitment	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	attributed	attribute	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	VCAM-1	vcam-1	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	appears	appear	VBZ	VBZ	_	15	acl:relcl	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	mediated	mediate	VBN	VBN	_	18	xcomp	_	_
22	through	through	IN	IN	_	23	case	_	_
23	AP-1	ap-1	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	GATA	gata	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	LDL	ldl	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	VCAM-inducer	vcam-inducer	NN	NN	_	3	nmod	_	_
8	possibly	possibly	RB	RB	_	9	advmod	_	_
9	distinct	distinct	JJ	JJ	_	7	amod	_	_
10	from	from	IN	IN	_	11	case	_	_
11	cytokines	cytokine	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	endotoxin	endotoxin	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	expression	expression	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	1	nmod	_	_
8	from	from	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	squirrel	squirrel	NN	NN	_	11	compound	_	_
11	monkey	monkey	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	Saimiri	saimiri	FW	FW	_	15	compound	_	_
14	boliviensis	boliviensis	FW	FW	_	15	compound	_	_
15	boliviensis	boliviensis	FW	FW	_	11	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	11	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	glucocorticoid-resistant	glucocorticoid-resistant	JJ	JJ	_	20	amod	_	_
20	primate	primate	NN	NN	_	11	appos	_	_
21	.	.	.	.	_	1	punct	_	_

1	New	new	JJ	JJ	_	3	amod	_	_
2	World	world	NN	NN	_	3	compound	_	_
3	primates	primate	NNS	NNS	_	10	nsubj	_	_
4	such	such	JJ	JJ	_	8	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	the	the	DT	DT	_	8	det	_	_
7	squirrel	squirrel	NN	NN	_	8	compound	_	_
8	monkey	monkey	NN	NN	_	3	nmod	_	_
9	have	have	VBP	VBP	_	10	aux	_	_
10	elevated	elevate	VBN	VBN	_	0	root	_	_
11	cortisol	cortisol	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	resistance	resistance	NN	NN	_	12	conj	_	_
16	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	apparent	apparent	JJ	JJ	_	8	amod	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	affinity	affinity	NN	NN	_	19	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	squirrel	squirrel	NN	NN	_	16	compound	_	_
15	monkey	monkey	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	5-fold	5-fold	RB	RB	_	19	advmod	_	_
19	lower	lower	JJR	JJR	_	3	ccomp	_	_
20	than	than	IN	IN	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	apparent	apparent	JJ	JJ	_	27	amod	_	_
27	Kd	kd	NN	NN	_	19	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	20.9	20.9	CD	CD	_	27	appos	_	_
30	+/-	+/-	CC	CC	_	29	cc	_	_
31	1.8	1.8	CD	CD	_	29	conj	_	_
32	and	and	CC	CC	_	29	cc	_	_
33	4.3	4.3	CD	CD	_	29	conj	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	0.2	0.2	CD	CD	_	33	conj	_	_
36	nmol/L	nmol/l	NN	NN	_	29	dep	_	_
37	,	,	,	,	_	27	punct	_	_
38	respectively	respectively	RB	RB	_	27	advmod	_	_
39	;	;	:	:	_	27	punct	_	_
40	n	n	NN	NN	_	27	dep	_	_
41	=	=	JJ	JJ	_	40	amod	_	_
42	3	3	CD	CD	_	41	dep	_	_
43	)	)	-RRB-	-RRB-	_	27	punct	_	_
44	,	,	,	,	_	19	punct	_	_
45	consistent	consistent	JJ	JJ	_	19	advmod	_	_
46	with	with	IN	IN	_	48	case	_	_
47	previous	previous	JJ	JJ	_	48	amod	_	_
48	studies	study	NNS	NNS	_	45	nmod	_	_
49	in	in	IN	IN	_	51	case	_	_
50	mononuclear	mononuclear	JJ	JJ	_	51	amod	_	_
51	leukocytes	leukocyte	NNS	NNS	_	48	nmod	_	_
52	isolated	isolate	VBN	VBN	_	51	acl	_	_
53	from	from	IN	IN	_	56	case	_	_
54	the	the	DT	DT	_	56	det	_	_
55	two	two	CD	CD	_	56	nummod	_	_
56	species	species	NNS	NNS	_	52	nmod	_	_
57	.	.	.	.	_	3	punct	_	_

1	As	as	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	step	step	NN	NN	_	19	nmod	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	understanding	understand	VBG	VBG	_	4	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	decreased	decrease	VBN	VBN	_	12	amod	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	affinity	affinity	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	New	new	JJ	JJ	_	16	amod	_	_
15	World	world	NN	NN	_	16	compound	_	_
16	primates	primate	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	used	use	VBD	VBD	_	0	root	_	_
20	reverse	reverse	JJ	JJ	_	21	amod	_	_
21	transcription-PCR	transcription-pcr	NN	NN	_	19	dobj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	clone	clone	VB	VB	_	19	advcl	_	_
24	the	the	DT	DT	_	26	det	_	_
25	glucocorticoid	glucocorticoid	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	23	dobj	_	_
27	from	from	IN	IN	_	30	case	_	_
28	squirrel	squirrel	NN	NN	_	30	compound	_	_
29	monkey	monkey	NN	NN	_	30	compound	_	_
30	liver	liver	NN	NN	_	23	nmod	_	_
31	and	and	CC	CC	_	19	cc	_	_
32	have	have	VBP	VBP	_	33	aux	_	_
33	compared	compare	VBN	VBN	_	19	conj	_	_
34	the	the	DT	DT	_	35	det	_	_
35	sequence	sequence	NN	NN	_	33	dobj	_	_
36	to	to	TO	TO	_	38	case	_	_
37	receptor	receptor	NN	NN	_	38	compound	_	_
38	sequences	sequence	NNS	NNS	_	33	nmod	_	_
39	obtained	obtain	VBN	VBN	_	38	acl	_	_
40	from	from	IN	IN	_	43	case	_	_
41	owl	owl	NN	NN	_	43	compound	_	_
42	monkey	monkey	NN	NN	_	43	compound	_	_
43	liver	liver	NN	NN	_	39	nmod	_	_
44	,	,	,	,	_	43	punct	_	_
45	cotton-top	cotton-top	JJ	JJ	_	48	amod	_	_
46	tamarin	tamarin	NN	NN	_	48	compound	_	_
47	B95-8	b95-8	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	43	conj	_	_
49	,	,	,	,	_	43	punct	_	_
50	and	and	CC	CC	_	43	cc	_	_
51	human	human	JJ	JJ	_	52	amod	_	_
52	lymphocytes	lymphocyte	NNS	NNS	_	43	conj	_	_
53	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	squirrel	squirrel	NN	NN	_	3	compound	_	_
3	monkey	monkey	NN	NN	_	10	nsubj	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	3	dep	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	approximately	approximately	RB	RB	_	8	advmod	_	_
8	97	97	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	10	nmod:npmod	_	_
10	identical	identical	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	nucleotide	nucleotide	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	amino	amino	NN	NN	_	16	compound	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	12	conj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	receptor	receptor	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ligand-binding	ligand-binding	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	15	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	amino	amino	NN	NN	_	6	compound	_	_
6	acids	acid	NNS	NNS	_	3	appos	_	_
7	528-777	528-777	CD	CD	_	6	nummod	_	_
8	)	)	-RRB-	-RRB-	_	6	punct	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	squirrel	squirrel	NN	NN	_	12	compound	_	_
12	monkey	monkey	NN	NN	_	3	nmod	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	12	dep	_	_
15	contains	contain	VBZ	VBZ	_	0	root	_	_
16	four	four	CD	CD	_	19	nummod	_	_
17	amino	amino	NN	NN	_	19	compound	_	_
18	acid	acid	NN	NN	_	19	compound	_	_
19	differences	difference	NNS	NNS	_	15	dobj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	Ser551	ser551	NN	NN	_	19	dep	_	_
22	to	to	TO	TO	_	23	case	_	_
23	Thr	thr	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	21	punct	_	_
25	Ser616	ser616	NN	NN	_	21	conj	_	_
26	to	to	TO	TO	_	27	case	_	_
27	Ala	ala	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	21	punct	_	_
29	Ala618	ala618	NN	NN	_	21	conj	_	_
30	to	to	TO	TO	_	31	case	_	_
31	Ser	ser	NN	NN	_	29	nmod	_	_
32	,	,	,	,	_	21	punct	_	_
33	and	and	CC	CC	_	21	cc	_	_
34	Ile761	ile761	NN	NN	_	21	conj	_	_
35	to	to	TO	TO	_	36	case	_	_
36	Leu	leu	NN	NN	_	34	nmod	_	_
37	)	)	-RRB-	-RRB-	_	21	punct	_	_
38	,	,	,	,	_	19	punct	_	_
39	all	all	DT	DT	_	43	nsubj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	which	which	WDT	WDT	_	39	nmod	_	_
42	are	be	VBP	VBP	_	43	cop	_	_
43	present	present	JJ	JJ	_	19	acl:relcl	_	_
44	in	in	IN	IN	_	46	case	_	_
45	owl	owl	NN	NN	_	46	compound	_	_
46	monkey	monkey	NN	NN	_	43	nmod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	cotton-top	cotton-top	JJ	JJ	_	49	amod	_	_
49	tamarin	tamarin	NN	NN	_	46	conj	_	_
50	receptors	receptor	NNS	NNS	_	46	dep	_	_
51	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	11	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	amino	amino	NN	NN	_	6	compound	_	_
6	acids	acid	NNS	NNS	_	3	appos	_	_
7	421-486	421-486	CD	CD	_	6	nummod	_	_
8	)	)	-RRB-	-RRB-	_	6	punct	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	completely	completely	RB	RB	_	11	advmod	_	_
11	conserved	conserve	VBN	VBN	_	0	root	_	_
12	among	among	IN	IN	_	13	case	_	_
13	human	human	JJ	JJ	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	squirrel	squirrel	NN	NN	_	16	compound	_	_
16	monkey	monkey	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	owl	owl	NN	NN	_	19	compound	_	_
19	monkey	monkey	NN	NN	_	13	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	cotton-top	cotton-top	JJ	JJ	_	23	amod	_	_
23	tamarin	tamarin	NN	NN	_	13	conj	_	_
24	receptors	receptor	NNS	NNS	_	13	dep	_	_
25	.	.	.	.	_	11	punct	_	_

1	Twenty-two	twenty-two	CD	CD	_	2	nummod	_	_
2	differences	difference	NNS	NNS	_	8	nsubjpass	_	_
3	from	from	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	sequence	sequence	NN	NN	_	2	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	N-terminal	n-terminal	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	amino	amino	NN	NN	_	15	compound	_	_
15	acids	acid	NNS	NNS	_	12	appos	_	_
16	1-421	1-421	CD	CD	_	15	nummod	_	_
17	)	)	-RRB-	-RRB-	_	15	punct	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	squirrel	squirrel	NN	NN	_	22	compound	_	_
21	monkey	monkey	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	None	none	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	substitutions	substitution	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	ligand-binding	ligand-binding	JJ	JJ	_	8	amod	_	_
8	domain	domain	NN	NN	_	1	nmod	_	_
9	matched	match	VBD	VBD	_	0	root	_	_
10	mutations	mutation	NNS	NNS	_	9	dobj	_	_
11	known	know	VBN	VBN	_	10	acl	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	influence	influence	VB	VB	_	11	xcomp	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	affinity	affinity	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	species	species	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	substitutions	substitution	NNS	NNS	_	9	nsubj	_	_
6	per	per	FW	FW	_	7	compound	_	_
7	se	se	FW	FW	_	5	advmod	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	responsible	responsible	JJ	JJ	_	2	ccomp	_	_
10	for	for	IN	IN	_	12	case	_	_
11	decreased	decrease	VBN	VBN	_	12	amod	_	_
12	affinity	affinity	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	squirrel	squirrel	NN	NN	_	15	compound	_	_
15	monkey	monkey	NN	NN	_	21	nsubjpass	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	15	conj	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	expressed	express	VBN	VBN	_	2	parataxis	_	_
22	in	in	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	TNT	tnt	NN	NN	_	28	compound	_	_
25	Coupled	coupled	JJ	JJ	_	28	amod	_	_
26	Reticulocyte	reticulocyte	NN	NN	_	28	compound	_	_
27	Lysate	lysate	NN	NN	_	28	compound	_	_
28	System	system	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Expressions	expression	NNS	NNS	_	25	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	human	human	JJ	JJ	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	squirrel	squirrel	NN	NN	_	6	compound	_	_
6	monkey	monkey	NN	NN	_	3	conj	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	3	dep	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	a	a	DT	DT	_	13	det	_	_
11	squirrel	squirrel	NN	NN	_	13	compound	_	_
12	monkey	monkey	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	3	conj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	18	nmod	_	_
16	Phe774	phe774	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	mutated	mutate	VBN	VBN	_	3	acl:relcl	_	_
19	to	to	TO	TO	_	20	case	_	_
20	Leu	leu	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	F774L	f774l	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	were	be	VBD	VBD	_	25	cop	_	_
25	similar	similar	JJ	JJ	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	expressed	express	VBN	VBN	_	14	advcl	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	TNT	tnt	NN	NN	_	6	compound	_	_
6	System	system	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	14	punct	_	_
8	squirrel	squirrel	NN	NN	_	9	compound	_	_
9	monkey	monkey	NN	NN	_	14	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	9	conj	_	_
14	had	have	VBD	VBD	_	0	root	_	_
15	similar	similar	JJ	JJ	_	19	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	high	high	JJ	JJ	_	15	dep	_	_
18	affinity	affinity	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	14	dobj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	dexamethasone	dexamethasone	NN	NN	_	19	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	apparent	apparent	JJ	JJ	_	24	amod	_	_
24	Kd	kd	NN	NN	_	19	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	5.9	5.9	CD	CD	_	24	appos	_	_
27	+/-	+/-	CC	CC	_	26	cc	_	_
28	1.2	1.2	CD	CD	_	26	conj	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	4.3	4.3	CD	CD	_	26	conj	_	_
31	+/-	+/-	CC	CC	_	30	cc	_	_
32	0.5	0.5	CD	CD	_	30	conj	_	_
33	nmol/L	nmol/l	NN	NN	_	26	dep	_	_
34	,	,	,	,	_	26	punct	_	_
35	respectively	respectively	RB	RB	_	26	advmod	_	_
36	;	;	:	:	_	24	punct	_	_
37	n	n	NN	NN	_	24	dep	_	_
38	=	=	JJ	JJ	_	37	amod	_	_
39	3	3	CD	CD	_	38	dep	_	_
40	)	)	-RRB-	-RRB-	_	24	punct	_	_
41	,	,	,	,	_	14	punct	_	_
42	whereas	whereas	IN	IN	_	48	mark	_	_
43	the	the	DT	DT	_	47	det	_	_
44	squirrel	squirrel	NN	NN	_	47	compound	_	_
45	monkey	monkey	NN	NN	_	47	compound	_	_
46	F774L	f774l	NN	NN	_	47	compound	_	_
47	receptor	receptor	NN	NN	_	48	nsubj	_	_
48	had	have	VBD	VBD	_	14	advcl	_	_
49	lower	lower	JJR	JJR	_	51	amod	_	_
50	affinity	affinity	NN	NN	_	51	compound	_	_
51	binding	binding	NN	NN	_	48	dobj	_	_
52	(	(	-LRB-	-LRB-	_	54	punct	_	_
53	apparent	apparent	JJ	JJ	_	54	amod	_	_
54	Kd	kd	NN	NN	_	51	dep	_	_
55	,	,	,	,	_	54	punct	_	_
56	20.4	20.4	CD	CD	_	59	nummod	_	_
57	+/-	+/-	CC	CC	_	56	cc	_	_
58	2.0	2.0	CD	CD	_	56	conj	_	_
59	nmol/L	nmol/l	NN	NN	_	54	appos	_	_
60	;	;	:	:	_	54	punct	_	_
61	n	n	NN	NN	_	54	dep	_	_
62	=	=	JJ	JJ	_	61	amod	_	_
63	3	3	CD	CD	_	62	dep	_	_
64	)	)	-RRB-	-RRB-	_	54	punct	_	_
65	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	substitutions	substitution	NNS	NNS	_	16	nsubj	_	_
4	within	within	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	ligand-binding	ligand-binding	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	squirrel	squirrel	NN	NN	_	11	compound	_	_
11	monkey	monkey	NN	NN	_	7	nmod	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	11	dep	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	account	account	VB	VB	_	0	root	_	_
17	for	for	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	decreased	decrease	VBN	VBN	_	21	amod	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	affinity	affinity	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	receptors	receptor	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	squirrel	squirrel	NN	NN	_	28	compound	_	_
27	monkey	monkey	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	Rather	rather	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	affinity	affinity	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	probably	probably	RB	RB	_	8	advmod	_	_
8	influenced	influence	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cytosolic	cytosolic	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	affect	affect	VBP	VBP	_	14	acl:relcl	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	inhibitor	inhibitor	NN	NN	_	8	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	tepoxalin	tepoxalin	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	adhesion	adhesion	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	10	nmod	_	_
16	CD62E	cd62e	NN	NN	_	15	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	CD11b/CD18	cd11b/cd18	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	CD106	cd106	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	Tepoxalin	tepoxalin	NN	NN	_	13	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	dual	dual	JJ	JJ	_	6	amod	_	_
5	enzyme	enzyme	NN	NN	_	6	compound	_	_
6	inhibitor	inhibitor	NN	NN	_	1	appos	_	_
7	of	of	IN	IN	_	8	case	_	_
8	cyclooxygenase	cyclooxygenase	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	5-lipoxygenase	5-lipoxygenase	NN	NN	_	8	conj	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	shown	show	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	inhibit	inhibit	VB	VB	_	13	xcomp	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	13	punct	_	_

1	Its	its	PRP$	PRP$	_	3	nmod:poss	_	_
2	immunosuppressive	immunosuppressive	JJ	JJ	_	3	amod	_	_
3	property	property	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	distinct	distinct	JJ	JJ	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	cyclosporin	cyclosporin	NN	NN	_	5	nmod	_	_
8	because	because	IN	IN	_	16	mark	_	_
9	only	only	RB	RB	_	10	advmod	_	_
10	tepoxalin	tepoxalin	NN	NN	_	16	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	10	cc	_	_
14	cyclosporin	cyclosporin	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	suppresses	suppress	VBZ	VBZ	_	5	advcl	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	tepoxalin	tepoxalin	NN	NN	_	7	nsubj	_	_
6	selectively	selectively	RB	RB	_	7	advmod	_	_
7	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
8	intercellular	intercellular	JJ	JJ	_	18	amod	_	_
9	adhesion	adhesion	NN	NN	_	18	compound	_	_
10	molecule-1	molecule-1	NN	NN	_	18	compound	_	_
11	(	(	-LRB-	-LRB-	_	18	punct	_	_
12	ICAM-1	icam-1	NN	NN	_	18	compound	_	_
13	,	,	,	,	_	18	punct	_	_
14	CD54	cd54	NN	NN	_	18	dep	_	_
15	)	)	-RRB-	-RRB-	_	18	punct	_	_
16	/MAC-1	/mac-1	NN	NN	_	18	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	CD11b/CD18	cd11b/cd18	NN	NN	_	20	nmod:npmod	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	dependent	dependent	JJ	JJ	_	21	amod	_	_
21	adhesion	adhesion	NN	NN	_	7	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	polymorphonuclear	polymorphonuclear	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	to	to	TO	TO	_	32	case	_	_
26	IL-1	il-1	NN	NN	_	27	nmod:npmod	_	_
27	activated	activated	JJ	JJ	_	32	amod	_	_
28	human	human	JJ	JJ	_	32	amod	_	_
29	umbilical	umbilical	JJ	JJ	_	32	amod	_	_
30	vein	vein	NN	NN	_	32	compound	_	_
31	endothelial	endothelial	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	21	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	inhibition	inhibition	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	related	related	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	several	several	JJ	JJ	_	15	amod	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	adhesion	adhesion	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Flow	flow	NN	NN	_	3	compound	_	_
2	cytometry	cytometry	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	29	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	cultured	culture	VBN	VBN	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	that	that	WDT	WDT	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	treated	treat	VBN	VBN	_	6	acl:relcl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	tepoxalin	tepoxalin	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	antisense	antisense	JJ	JJ	_	14	amod	_	_
14	oligonucleotides	oligonucleotide	NNS	NNS	_	11	conj	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	P65/p50	p65/p50	NN	NN	_	18	compound	_	_
18	subunit	subunit	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	9	punct	_	_
23	and	and	CC	CC	_	9	cc	_	_
24	then	then	RB	RB	_	25	advmod	_	_
25	stimulated	stimulate	VBN	VBN	_	9	conj	_	_
26	with	with	IN	IN	_	27	case	_	_
27	PMA	pma	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	9	punct	_	_
29	revealed	reveal	VBD	VBD	_	0	root	_	_
30	a	a	DT	DT	_	32	det	_	_
31	reduced	reduce	VBN	VBN	_	32	amod	_	_
32	expression	expression	NN	NN	_	29	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	CD11b/CD18	cd11b/cd18	NN	NN	_	32	nmod	_	_
35	on	on	IN	IN	_	38	case	_	_
36	monocytic	monocytic	JJ	JJ	_	38	amod	_	_
37	HL60	hl60	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	32	nmod	_	_
39	,	,	,	,	_	32	punct	_	_
40	and	and	CC	CC	_	32	cc	_	_
41	endothelial	endothelial	JJ	JJ	_	43	amod	_	_
42	adhesion	adhesion	NN	NN	_	43	compound	_	_
43	molecule-1	molecule-1	NN	NN	_	32	conj	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	CD62E	cd62e	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	and	and	CC	CC	_	43	cc	_	_
48	vascular	vascular	JJ	JJ	_	50	amod	_	_
49	adhesion	adhesion	NN	NN	_	50	compound	_	_
50	molecule-1	molecule-1	NN	NN	_	43	conj	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	CD106	cd106	NN	NN	_	50	appos	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	on	on	IN	IN	_	59	case	_	_
55	human	human	JJ	JJ	_	59	amod	_	_
56	umbilical	umbilical	JJ	JJ	_	59	amod	_	_
57	vein	vein	NN	NN	_	59	compound	_	_
58	endothelial	endothelial	JJ	JJ	_	59	amod	_	_
59	cells	cell	NNS	NNS	_	43	nmod	_	_
60	.	.	.	.	_	29	punct	_	_

1	Expression	expression	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	other	other	JJ	JJ	_	5	amod	_	_
4	adhesion	adhesion	NN	NN	_	5	compound	_	_
5	molecules	molecule	NNS	NNS	_	1	nmod	_	_
6	such	such	JJ	JJ	_	10	case	_	_
7	as	as	IN	IN	_	6	mwe	_	_
8	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
9	function	function	NN	NN	_	10	compound	_	_
10	associated-antigen-1	associated-antigen-1	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CD11a/CD18	cd11a/cd18	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	CD54	cd54	NN	NN	_	10	conj	_	_
16	were	be	VBD	VBD	_	17	cop	_	_
17	unaffected	unaffected	JJ	JJ	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Tepoxalin	tepoxalin	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	secretion	secretion	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	nmod:npmod	_	_
10	regulated	regulated	JJ	JJ	_	11	amod	_	_
11	chemokine	chemokine	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	IL-8	il-8	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	known	known	JJ	JJ	_	17	amod	_	_
17	inducer	inducer	NN	NN	_	11	appos	_	_
18	of	of	IN	IN	_	20	case	_	_
19	CD11b/CD18	cd11b/cd18	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	suppression	suppression	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	CD11b/CD18	cd11b/cd18	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	tepoxalin	tepoxalin	NN	NN	_	3	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	involve	involve	VB	VB	_	0	root	_	_
11	IL-8	il-8	NN	NN	_	10	dobj	_	_
12	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	inhibiting	inhibit	VBG	VBG	_	19	advcl	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	19	punct	_	_
11	surface	surface	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	19	nsubjpass	_	_
13	of	of	IN	IN	_	16	case	_	_
14	several	several	JJ	JJ	_	16	amod	_	_
15	adhesion	adhesion	NN	NN	_	16	compound	_	_
16	molecules	molecule	NNS	NNS	_	12	nmod	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	modulated	modulate	VBN	VBN	_	3	ccomp	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	tepoxalin	tepoxalin	NN	NN	_	25	nsubj	_	_
23	may	may	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	cop	_	_
25	useful	useful	JJ	JJ	_	19	conj	_	_
26	in	in	IN	IN	_	27	mark	_	_
27	treating	treat	VBG	VBG	_	25	advcl	_	_
28	selected	select	VBN	VBN	_	31	amod	_	_
29	adhesion	adhesion	NN	NN	_	30	nmod:npmod	_	_
30	mediated	mediated	JJ	JJ	_	31	amod	_	_
31	events	event	NNS	NNS	_	27	dobj	_	_
32	such	such	JJ	JJ	_	35	case	_	_
33	as	as	IN	IN	_	32	mwe	_	_
34	leukocyte	leukocyte	NN	NN	_	35	compound	_	_
35	migration	migration	NN	NN	_	31	nmod	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	atherosclerotic	atherosclerotic	JJ	JJ	_	39	amod	_	_
38	plaque	plaque	NN	NN	_	39	compound	_	_
39	formation	formation	NN	NN	_	35	conj	_	_
40	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	platelet/endothelial	platelet/endothelial	JJ	JJ	_	9	amod	_	_
6	cell	cell	NN	NN	_	9	compound	_	_
7	adhesion	adhesion	NN	NN	_	9	compound	_	_
8	molecule-1	molecule-1	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	1	nmod	_	_
10	:	:	:	:	_	1	punct	_	_
11	identification	identification	NN	NN	_	1	dep	_	_
12	of	of	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	GATA-2	gata-2	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	11	nmod	_	_
17	required	require	VBN	VBN	_	16	acl	_	_
18	for	for	IN	IN	_	21	case	_	_
19	optimal	optimal	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	19	dep	_	_
21	activity	activity	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	Platelet/endothelial	platelet/endothelial	JJ	JJ	_	4	amod	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	adhesion	adhesion	NN	NN	_	4	compound	_	_
4	molecule-1	molecule-1	NN	NN	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PECAM-1	pecam-1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	130-kD	130-kd	JJ	JJ	_	11	amod	_	_
11	member	member	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	Ig	ig	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	superfamily	superfamily	NN	NN	_	11	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	expressed	express	VBN	VBN	_	11	acl:relcl	_	_
20	on	on	IN	IN	_	21	case	_	_
21	platelets	platelet	NNS	NNS	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	endothelial	endothelial	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	certain	certain	JJ	JJ	_	29	amod	_	_
28	leukocyte	leukocyte	NN	NN	_	29	compound	_	_
29	subsets	subset	NNS	NNS	_	21	conj	_	_
30	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	factors	factor	NNS	NNS	_	2	dobj	_	_
5	controlling	control	VBG	VBG	_	4	acl	_	_
6	vascular-specific	vascular-specific	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PECAM-1	pecam-1	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	cloned	clone	VBD	VBD	_	2	parataxis	_	_
13	the	the	DT	DT	_	15	det	_	_
14	5'-flanking	5'-flanking	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	PECAM-1	pecam-1	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	analyzed	analyze	VBD	VBD	_	12	conj	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	activity	activity	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	2	punct	_	_

1	5'-Rapid	5'-rapid	JJ	JJ	_	2	amod	_	_
2	amplification	amplification	NN	NN	_	9	compound	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	ends	end	NNS	NNS	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	5'-RACE	5'-race	NNS	NNS	_	2	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	analysis	analysis	NN	NN	_	10	nsubj	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	initiation	initiation	NN	NN	_	14	nsubj	_	_
14	occurred	occur	VBD	VBD	_	10	ccomp	_	_
15	at	at	IN	IN	_	20	case	_	_
16	several	several	JJ	JJ	_	20	amod	_	_
17	closely	closely	RB	RB	_	18	advmod	_	_
18	spaced	spaced	JJ	JJ	_	16	dep	_	_
19	nearby	nearby	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	14	nmod	_	_
21	originating	originate	VBG	VBG	_	20	acl	_	_
22	approximately	approximately	RB	RB	_	24	advmod	_	_
23	204	204	CD	CD	_	24	nummod	_	_
24	bp	bp	NN	NN	_	21	nmod	_	_
25	upstream	upstream	RB	RB	_	24	advmod	_	_
26	from	from	IN	IN	_	24	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	translation	translation	NN	NN	_	30	compound	_	_
29	start	start	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	24	dep	_	_
31	.	.	.	.	_	10	punct	_	_

1	Analysis	analysis	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	sequence	sequence	NN	NN	_	1	nmod	_	_
5	immediately	immediately	RB	RB	_	6	advmod	_	_
6	upstream	upstream	JJ	JJ	_	4	advmod	_	_
7	from	from	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	initiation	initiation	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TIS	tis	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	no	no	DT	DT	_	18	neg	_	_
17	canonical	canonical	JJ	JJ	_	18	amod	_	_
18	TATA	tata	NN	NN	_	15	dobj	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	CAAT	caat	NN	NN	_	21	compound	_	_
21	elements	element	NNS	NNS	_	18	conj	_	_
22	,	,	,	,	_	15	punct	_	_
23	however	however	RB	RB	_	15	advmod	_	_
24	an	a	DT	DT	_	26	det	_	_
25	initiator	initiator	NN	NN	_	26	compound	_	_
26	element	element	NN	NN	_	32	nsubj	_	_
27	commonly	commonly	RB	RB	_	28	advmod	_	_
28	found	find	VBN	VBN	_	26	acl	_	_
29	in	in	IN	IN	_	31	case	_	_
30	TATA-less	tata-less	JJ	JJ	_	31	amod	_	_
31	promoters	promoter	NNS	NNS	_	28	nmod	_	_
32	encompassed	encompass	VBD	VBD	_	15	parataxis	_	_
33	the	the	DT	DT	_	34	det	_	_
34	TIS	tis	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	15	punct	_	_

1	5'-serially	5'-serially	RB	RB	_	5	advmod	_	_
2	truncated	truncate	VBN	VBN	_	5	amod	_	_
3	PECAM-1	pecam-1	NN	NN	_	5	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	segments	segment	NNS	NNS	_	13	nsubj	_	_
6	cloned	clone	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	8	case	_	_
8	front	front	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	luciferase	luciferase	NN	NN	_	12	compound	_	_
12	reporter	reporter	NN	NN	_	8	nmod	_	_
13	drove	drive	VBD	VBD	_	0	root	_	_
14	transcription	transcription	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	21	case	_	_
16	both	both	CC	CC	_	21	dep	_	_
17	a	a	DT	DT	_	21	det	_	_
18	lineage-	lineage-	NN	NN	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	orientation-specific	orientation-specific	JJ	JJ	_	18	conj	_	_
21	manner	manner	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Putative	putative	JJ	JJ	_	4	amod	_	_
2	cis-acting	cis-acting	JJ	JJ	_	4	amod	_	_
3	control	control	NN	NN	_	4	compound	_	_
4	elements	element	NNS	NNS	_	11	nsubj	_	_
5	present	present	JJ	JJ	_	4	amod	_	_
6	within	within	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	300-bp	300-bp	JJ	JJ	_	10	amod	_	_
9	core	core	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	5	nmod	_	_
11	included	include	VBD	VBD	_	0	root	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	ets	ets	NN	NN	_	14	compound	_	_
14	sites	site	NNS	NNS	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	an	a	DT	DT	_	18	det	_	_
17	Sp1	sp1	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	tandem	tandem	JJ	JJ	_	22	amod	_	_
21	E-box	e-box	NN	NN	_	22	compound	_	_
22	domains	domain	NNS	NNS	_	14	conj	_	_
23	,	,	,	,	_	14	punct	_	_
24	two	two	CD	CD	_	26	nummod	_	_
25	GATA-associated	gata-associated	JJ	JJ	_	26	amod	_	_
26	sites	site	NNS	NNS	_	14	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	CACCC	caccc	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	14	punct	_	_
31	an	a	DT	DT	_	34	det	_	_
32	AP-2	ap-2	NN	NN	_	34	compound	_	_
33	binding	binding	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	14	conj	_	_
35	,	,	,	,	_	14	punct	_	_
36	and	and	CC	CC	_	14	cc	_	_
37	a	a	DT	DT	_	39	det	_	_
38	GATA	gata	NN	NN	_	39	compound	_	_
39	element	element	NN	NN	_	14	conj	_	_
40	at	at	IN	IN	_	41	case	_	_
41	-24	-24	CD	CD	_	39	nmod	_	_
42	.	.	.	.	_	11	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	optimal	optimal	JJ	JJ	_	7	amod	_	_
6	transcriptional	transcriptional	JJ	JJ	_	5	dep	_	_
7	activity	activity	NN	NN	_	8	nsubj	_	_
8	required	require	VBD	VBD	_	3	ccomp	_	_
9	the	the	DT	DT	_	11	det	_	_
10	GATA	gata	NN	NN	_	11	compound	_	_
11	sequence	sequence	NN	NN	_	8	dobj	_	_
12	at	at	IN	IN	_	13	case	_	_
13	position	position	NN	NN	_	11	nmod	_	_
14	-24	-24	CD	CD	_	13	dep	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	gel-shift	gel-shift	JJ	JJ	_	18	amod	_	_
18	assays	assay	NNS	NNS	_	20	nsubj	_	_
19	further	further	RB	RB	_	20	advmod	_	_
20	showed	show	VBD	VBD	_	3	conj	_	_
21	that	that	IN	IN	_	31	mark	_	_
22	the	the	DT	DT	_	25	det	_	_
23	GATA-2	gata-2	NN	NN	_	25	compound	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	31	nsubj	_	_
26	,	,	,	,	_	25	punct	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	25	cc	_	_
29	GATA-1	gata-1	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	bound	bind	VBD	VBD	_	20	ccomp	_	_
32	to	to	TO	TO	_	34	case	_	_
33	this	this	DT	DT	_	34	det	_	_
34	region	region	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	PECAM-1	pecam-1	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Understanding	understand	VBG	VBG	_	15	csubj	_	_
2	the	the	DT	DT	_	3	dep	_	_
3	cis-	cis-	JJ	JJ	_	1	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	transacting	transact	VBG	VBG	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	3	conj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	regulate	regulate	VBP	VBP	_	3	acl:relcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	tissue-specific	tissue-specific	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	PECAM-1	pecam-1	NN	NN	_	11	nmod	_	_
14	should	should	MD	MD	_	15	aux	_	_
15	increase	increase	VB	VB	_	0	root	_	_
16	our	we	PRP$	PRP$	_	17	nmod:poss	_	_
17	understanding	understanding	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	27	nmod	_	_
23	vascular-specific	vascular-specific	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	achieved	achieve	VBN	VBN	_	20	acl:relcl	_	_
28	.	.	.	.	_	15	punct	_	_

1	Rapid	rapid	JJ	JJ	_	3	amod	_	_
2	Ca2+-mediated	ca2+-mediated	JJ	JJ	_	1	dep	_	_
3	activation	activation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Rap1	rap1	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	platelets	platelet	NNS	NNS	_	3	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	Rap1	rap1	NN	NN	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	a	a	DT	DT	_	7	det	_	_
4	small	small	JJ	JJ	_	7	amod	_	_
5	,	,	,	,	_	7	punct	_	_
6	Ras-like	ras-like	JJ	JJ	_	7	amod	_	_
7	GTPase	gtpase	NN	NN	_	0	root	_	_
8	whose	whose	WP$	WP$	_	9	nmod:poss	_	_
9	function	function	NN	NN	_	15	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	regulation	regulation	NN	NN	_	9	conj	_	_
12	are	be	VBP	VBP	_	15	cop	_	_
13	still	still	RB	RB	_	15	advmod	_	_
14	largely	largely	RB	RB	_	15	advmod	_	_
15	unknown	unknown	JJ	JJ	_	7	acl:relcl	_	_
16	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	developed	develop	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	assay	assay	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	monitor	monitor	VB	VB	_	6	acl	_	_
9	the	the	DT	DT	_	13	det	_	_
10	active	active	JJ	JJ	_	13	amod	_	_
11	,	,	,	,	_	13	punct	_	_
12	GTP-bound	gtp-bound	JJ	JJ	_	13	amod	_	_
13	form	form	NN	NN	_	8	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Rap1	rap1	NN	NN	_	13	nmod	_	_
16	based	base	VBN	VBN	_	20	case	_	_
17	on	on	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	differential	differential	JJ	JJ	_	20	amod	_	_
20	affinity	affinity	NN	NN	_	8	advcl	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Rap1GTP	rap1gtp	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Rap1GDP	rap1gdp	NN	NN	_	22	conj	_	_
25	for	for	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	Rap	rap	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	domain	domain	NN	NN	_	20	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	RalGDS	ralgds	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	RBD	rbd	NN	NN	_	29	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	3	punct	_	_

1	Stimulation	stimulation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	blood	blood	NN	NN	_	4	compound	_	_
4	platelets	platelet	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	alpha-thrombin	alpha-thrombin	NN	NN	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	other	other	JJ	JJ	_	10	amod	_	_
9	platelet	platelet	NN	NN	_	10	compound	_	_
10	activators	activator	NNS	NNS	_	6	conj	_	_
11	caused	cause	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	16	det	_	_
13	rapid	rapid	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	strong	strong	JJ	JJ	_	13	conj	_	_
16	induction	induction	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Rap1	rap1	NN	NN	_	16	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	associated	associate	VBD	VBD	_	16	acl:relcl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	RBD	rbd	NN	NN	_	20	nmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	20	advmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	Binding	binding	NN	NN	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	RBD	rbd	NN	NN	_	1	nmod	_	_
4	increased	increase	VBD	VBD	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	undetectable	undetectable	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	resting	rest	VBG	VBG	_	10	amod	_	_
10	platelets	platelet	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	&gt;	&gt;	JJR	JJR	_	13	advmod	_	_
13	50	50	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	4	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	total	total	JJ	JJ	_	17	amod	_	_
17	Rap1	rap1	NN	NN	_	14	nmod	_	_
18	within	within	IN	IN	_	20	case	_	_
19	30	30	CD	CD	_	20	nummod	_	_
20	s	s	NN	NN	_	4	nmod	_	_
21	after	after	IN	IN	_	22	case	_	_
22	stimulation	stimulation	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	10	nsubj	_	_
3	in	in	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
6	Ca2+	ca2+	NN	NN	_	7	compound	_	_
7	concentration	concentration	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	necessary	necessary	JJ	JJ	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	sufficient	sufficient	JJ	JJ	_	10	conj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	Rap1	rap1	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	10	nmod	_	_
16	since	since	IN	IN	_	19	mark	_	_
17	it	it	PRP	PRP	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	induced	induce	VBN	VBN	_	10	advcl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	agents	agent	NNS	NNS	_	19	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	increase	increase	VBP	VBP	_	21	acl:relcl	_	_
24	intracellular	intracellular	JJ	JJ	_	25	amod	_	_
25	Ca2+	ca2+	NN	NN	_	23	dobj	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	inhibited	inhibit	VBN	VBN	_	19	conj	_	_
28	by	by	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	Ca2+-chelating	ca2+-chelating	JJ	JJ	_	31	amod	_	_
31	agent	agent	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	inhibition	inhibition	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	translocation	translocation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Rap1	rap1	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cytoskeleton	cytoskeleton	NN	NN	_	4	nmod	_	_
10	nor	nor	CC	CC	_	2	cc	_	_
11	inhibition	inhibition	NN	NN	_	2	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	platelet	platelet	NN	NN	_	14	compound	_	_
14	aggregation	aggregation	NN	NN	_	11	nmod	_	_
15	affected	affect	VBD	VBD	_	0	root	_	_
16	thrombin-induced	thrombin-induced	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Rap1	rap1	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	prostaglandin	prostaglandin	NN	NN	_	5	compound	_	_
5	I2	i2	NN	NN	_	18	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PGI2	pgi2	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	strong	strong	JJ	JJ	_	13	amod	_	_
12	negative	negative	JJ	JJ	_	13	amod	_	_
13	regulator	regulator	NN	NN	_	5	appos	_	_
14	of	of	IN	IN	_	16	case	_	_
15	platelet	platelet	NN	NN	_	16	compound	_	_
16	function	function	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	inhibited	inhibit	VBD	VBD	_	0	root	_	_
19	agonist-induced	agonist-induced	JJ	JJ	_	18	dobj	_	_
20	as	as	RB	RB	_	19	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	Ca2+-induced	ca2+-induced	JJ	JJ	_	19	conj	_	_
24	activation	activation	NN	NN	_	19	dep	_	_
25	of	of	IN	IN	_	26	case	_	_
26	Rap1	rap1	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	results	result	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	conclude	conclude	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	Rap1	rap1	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	16	nsubj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	platelets	platelet	NNS	NNS	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	an	a	DT	DT	_	16	det	_	_
14	important	important	JJ	JJ	_	16	amod	_	_
15	common	common	JJ	JJ	_	14	dep	_	_
16	event	event	NN	NN	_	6	ccomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	early	early	JJ	JJ	_	20	amod	_	_
19	agonist-induced	agonist-induced	JJ	JJ	_	18	dep	_	_
20	signalling	signalling	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	this	this	DT	DT	_	25	det	_	_
25	activation	activation	NN	NN	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	mediated	mediate	VBN	VBN	_	16	conj	_	_
28	by	by	IN	IN	_	33	case	_	_
29	an	a	DT	DT	_	33	det	_	_
30	increased	increase	VBN	VBN	_	33	amod	_	_
31	intracellular	intracellular	JJ	JJ	_	33	amod	_	_
32	Ca2+	ca2+	NN	NN	_	33	compound	_	_
33	concentration	concentration	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	erythroid-specific	erythroid-specific	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	megakaryoblastic	megakaryoblastic	JJ	JJ	_	7	amod	_	_
7	disorders	disorder	NNS	NNS	_	1	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	Currently	currently	RB	RB	_	2	advmod	_	_
2	available	available	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	indicate	indicate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	megakaryocytic	megakaryocytic	JJ	JJ	_	6	conj	_	_
9	differentiation	differentiation	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	13	nsubj	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	closely	closely	RB	RB	_	13	advmod	_	_
13	related	related	JJ	JJ	_	4	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	each	each	DT	DT	_	16	det	_	_
16	other	other	JJ	JJ	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	there	there	EX	EX	_	21	expl	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	exist	exist	VB	VB	_	13	conj	_	_
22	progenitor	progenitor	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	21	dobj	_	_
24	common	common	JJ	JJ	_	23	amod	_	_
25	to	to	TO	TO	_	28	case	_	_
26	those	those	DT	DT	_	28	det	_	_
27	two	two	CD	CD	_	28	nummod	_	_
28	lineages	lineage	NNS	NNS	_	24	nmod	_	_
29	may	may	MD	MD	_	21	dep	_	_
30	exist	exist	VB	VB	_	21	dep	_	_
31	.	.	.	.	_	4	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	megakaryoblastic	megakaryoblastic	JJ	JJ	_	3	amod	_	_
3	leukemia	leukemia	NN	NN	_	19	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	AML-M7	aml-m7	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	transient	transient	JJ	JJ	_	10	amod	_	_
9	myeloproliferative	myeloproliferative	JJ	JJ	_	10	amod	_	_
10	disorder	disorder	NN	NN	_	3	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	Down	down	NN	NN	_	14	nmod:poss	_	_
13	's	's	POS	POS	_	12	case	_	_
14	syndrome	syndrome	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TMD	tmd	NN	NN	_	10	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	characterized	characterize	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	22	case	_	_
21	rapid	rapid	JJ	JJ	_	22	amod	_	_
22	growth	growth	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	abnormal	abnormal	JJ	JJ	_	26	amod	_	_
25	blast	blast	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	express	express	VBP	VBP	_	26	acl:relcl	_	_
29	megakaryocytic	megakaryocytic	JJ	JJ	_	30	amod	_	_
30	markers	marker	NNS	NNS	_	28	dobj	_	_
31	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	blast	blast	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	lineage-specific	lineage-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	dobj	_	_
8	such	such	JJ	JJ	_	10	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	GATA-1	gata-1	NN	NN	_	7	nmod	_	_
11	common	common	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	lineages	lineage	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	frequently	frequently	RB	RB	_	17	advmod	_	_
17	express	express	VBP	VBP	_	4	conj	_	_
18	erythroid-specific	erythroid-specific	JJ	JJ	_	19	amod	_	_
19	mRNAs	mrna	NNS	NNS	_	17	dobj	_	_
20	such	such	JJ	JJ	_	22	case	_	_
21	as	as	IN	IN	_	20	mwe	_	_
22	gamma-globin	gamma-globin	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	erythroid	erythroid	JJ	JJ	_	26	amod	_	_
25	delta-aminolevulinate	delta-aminolevulinate	NN	NN	_	26	compound	_	_
26	synthase	synthase	NN	NN	_	22	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	ALAS-E	alas-e	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	4	punct	_	_
31	indicating	indicate	VBG	VBG	_	4	advcl	_	_
32	that	that	IN	IN	_	42	mark	_	_
33	most	most	JJS	JJS	_	42	nsubj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	blasts	blast	NNS	NNS	_	33	nmod	_	_
37	in	in	IN	IN	_	41	case	_	_
38	M7	m7	NN	NN	_	41	compound	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	TMD	tmd	NN	NN	_	38	conj	_	_
41	cases	case	NNS	NNS	_	36	nmod	_	_
42	have	have	VBP	VBP	_	31	ccomp	_	_
43	erythroid	erythroid	JJ	JJ	_	46	amod	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	megakaryocytic	megakaryocytic	JJ	JJ	_	43	conj	_	_
46	phenotypes	phenotype	NNS	NNS	_	42	dobj	_	_
47	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	blasts	blast	NNS	NNS	_	11	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	M7	m7	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	TMD	tmd	NN	NN	_	7	conj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	correspond	correspond	VB	VB	_	3	ccomp	_	_
12	to	to	TO	TO	_	13	case	_	_
13	progenitors	progenitor	NNS	NNS	_	11	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	megakaryocytic	megakaryocytic	JJ	JJ	_	16	conj	_	_
19	lineages	lineage	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	NF-ATp	nf-atp	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	a	a	DT	DT	_	5	det	_	_
5	hallmark	hallmark	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	unstimulated	unstimulated	JJ	JJ	_	9	amod	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	B-CLL	b-cll	NN	NN	_	12	compound	_	_
12	patients	patient	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	17	nsubjpass	_	_
3	from	from	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
6	blood	blood	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	chronic	chronic	JJ	JJ	_	12	amod	_	_
11	lymphocytic	lymphocytic	JJ	JJ	_	12	amod	_	_
12	leukaemia	leukaemia	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	CLL	cll	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	analysed	analyse	VBN	VBN	_	0	root	_	_
18	for	for	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	presence	presence	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	binding	binding	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	panel	panel	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	27	nmod	_	_
31	which	which	WDT	WDT	_	33	nsubjpass	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	involved	involve	VBN	VBN	_	30	acl:relcl	_	_
34	in	in	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	control	control	NN	NN	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	lymphoid	lymphoid	JJ	JJ	_	40	amod	_	_
40	cells	cell	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	following	following	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	studied	study	VBN	VBN	_	0	root	_	_
7	:	:	:	:	_	6	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Octamer	octamer	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	6	dobj	_	_
11	Oct-1	oct-1	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Oct-2	oct-2	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	members	member	NNS	NNS	_	10	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	AP-1	ap-1	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	NF-AT	nf-at	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	10	conj	_	_
24	,	,	,	,	_	23	punct	_	_
25	in	in	IN	IN	_	26	case	_	_
26	particular	particular	JJ	JJ	_	27	nmod	_	_
27	NF-ATp	nf-atp	NN	NN	_	23	appos	_	_
28	,	,	,	,	_	10	punct	_	_
29	and	and	CC	CC	_	10	cc	_	_
30	members	member	NNS	NNS	_	10	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	Rel/NF-kB	rel/nf-kb	NN	NN	_	34	compound	_	_
34	family	family	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	23	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	translocation	translocation	NN	NN	_	23	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-ATp	nf-atp	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	member	member	NN	NN	_	9	appos	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	growing	grow	VBG	VBG	_	16	amod	_	_
16	family	family	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-AT	nf-at	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	a	a	DT	DT	_	23	det	_	_
23	hallmark	hallmark	NN	NN	_	2	ccomp	_	_
24	of	of	IN	IN	_	27	case	_	_
25	nonstimulated	nonstimulated	JJ	JJ	_	27	amod	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	from	from	IN	IN	_	30	case	_	_
29	CLL	cll	NN	NN	_	30	compound	_	_
30	patients	patient	NNS	NNS	_	27	nmod	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	distinguishes	distinguish	VBZ	VBZ	_	23	acl:relcl	_	_
33	B-CLL	b-cll	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	32	dobj	_	_
35	from	from	IN	IN	_	40	case	_	_
36	'	'	``	``	_	40	punct	_	_
37	normal	normal	JJ	JJ	_	40	amod	_	_
38	'	'	''	''	_	40	punct	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	lymphocytes	lymphocyte	NNS	NNS	_	32	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	appearance	appearance	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	NF-kB2/p52	nf-kb2/p52	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	6	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	binding	binding	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	further	further	JJ	JJ	_	6	amod	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	DNA	dna	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	such	such	JJ	JJ	_	12	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	JunD	jund	NN	NN	_	2	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	c-Fos	c-fos	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	FosB	fosb	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	2	punct	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	detected	detect	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	patients	patient	NNS	NNS	_	19	nmod	_	_
23	whereas	whereas	IN	IN	_	40	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	localisation	localisation	NN	NN	_	40	nsubj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	DNA	dna	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	25	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	other	other	JJ	JJ	_	31	amod	_	_
31	factors	factor	NNS	NNS	_	25	nmod	_	_
32	such	such	JJ	JJ	_	34	case	_	_
33	as	as	IN	IN	_	32	mwe	_	_
34	c-Jun	c-jun	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	RelA/p65	rela/p65	NN	NN	_	34	conj	_	_
37	and	and	CC	CC	_	34	cc	_	_
38	c-Rel	c-rel	NN	NN	_	34	conj	_	_
39	was	be	VBD	VBD	_	40	cop	_	_
40	unaltered	unaltered	JJ	JJ	_	19	advcl	_	_
41	.	.	.	.	_	19	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	remarkable	remarkable	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	in	in	IN	IN	_	7	case	_	_
6	B-CLL	b-cll	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	20	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	appearance	appearance	NN	NN	_	20	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	specific	specific	JJ	JJ	_	17	amod	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	10	nmod	_	_
18	is	be	VBZ	VBZ	_	20	aux	_	_
19	dramatically	dramatically	RB	RB	_	20	advmod	_	_
20	affected	affected	JJ	JJ	_	3	ccomp	_	_
21	whereas	whereas	IN	IN	_	29	mark	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	members	member	NNS	NNS	_	29	nsubj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	same	same	JJ	JJ	_	28	amod	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	family	family	NN	NN	_	23	nmod	_	_
29	remained	remain	VBD	VBD	_	20	advcl	_	_
30	unaltered	unaltered	JJ	JJ	_	29	xcomp	_	_
31	in	in	IN	IN	_	34	case	_	_
32	these	these	DT	DT	_	34	det	_	_
33	leukemic	leukemic	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	remains	remain	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	5	mark	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	2	xcomp	_	_
6	which	which	WDT	WDT	_	8	det	_	_
7	molecular	molecular	JJ	JJ	_	8	amod	_	_
8	events	event	NNS	NNS	_	9	nsubj	_	_
9	lead	lead	VBP	VBP	_	5	ccomp	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	'	'	``	``	_	14	punct	_	_
14	pre-activation	pre-activation	NN	NN	_	9	nmod	_	_
15	'	'	''	''	_	14	punct	_	_
16	,	,	,	,	_	14	punct	_	_
17	i.e.	i.e.	FW	FW	_	20	advmod	_	_
18	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	14	appos	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	14	punct	_	_
25	of	of	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	members	member	NNS	NNS	_	14	nmod	_	_
28	of	of	IN	IN	_	35	case	_	_
29	NF-AT	nf-at	NN	NN	_	35	compound	_	_
30	,	,	,	,	_	29	punct	_	_
31	NF-kB	nf-kb	NN	NN	_	29	conj	_	_
32	and	and	CC	CC	_	29	cc	_	_
33	AP-1	ap-1	NN	NN	_	29	conj	_	_
34	factor	factor	NN	NN	_	35	compound	_	_
35	families	family	NNS	NNS	_	27	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Physical	physical	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	functional	functional	JJ	JJ	_	1	conj	_	_
4	interaction	interaction	NN	NN	_	0	root	_	_
5	between	between	IN	IN	_	14	case	_	_
6	the	the	DT	DT	_	14	det	_	_
7	human	human	JJ	JJ	_	14	amod	_	_
8	T-cell	t-cell	NN	NN	_	14	compound	_	_
9	lymphotropic	lymphotropic	JJ	JJ	_	14	amod	_	_
10	virus	virus	NN	NN	_	14	compound	_	_
11	type	type	NN	NN	_	14	compound	_	_
12	1	1	CD	CD	_	14	nummod	_	_
13	Tax1	tax1	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	4	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	CCAAT	ccaat	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	14	conj	_	_
20	NF-Y	nf-y	NN	NN	_	19	dep	_	_
21	.	.	.	.	_	4	punct	_	_

1	Tax1	tax1	NN	NN	_	20	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potent	potent	JJ	JJ	_	5	amod	_	_
5	activator	activator	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	16	case	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	T-cell	t-cell	NN	NN	_	11	compound	_	_
9	lymphotropic	lymphotropic	JJ	JJ	_	11	amod	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	type	type	NN	NN	_	16	compound	_	_
12	1	1	CD	CD	_	11	nummod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HTLV-1	htlv-1	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	transcription	transcription	NN	NN	_	5	nmod	_	_
17	,	,	,	,	_	1	punct	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	shown	show	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	modulate	modulate	VB	VB	_	20	xcomp	_	_
23	expression	expression	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	many	many	JJ	JJ	_	27	amod	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	20	punct	_	_

1	Tax1	tax1	NN	NN	_	4	nsubj	_	_
2	does	do	VBZ	VBZ	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	bind	bind	VB	VB	_	0	root	_	_
5	DNA	dna	NN	NN	_	4	dobj	_	_
6	directly	directly	RB	RB	_	4	advmod	_	_
7	but	but	CC	CC	_	4	cc	_	_
8	regulates	regulate	VBZ	VBZ	_	4	conj	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	through	through	IN	IN	_	12	case	_	_
11	protein-protein	protein-protein	JJ	JJ	_	12	amod	_	_
12	interactions	interaction	NNS	NNS	_	9	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	sequence-specific	sequence-specific	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	5	det	_	_
3	yeast	yeast	NN	NN	_	5	compound	_	_
4	two-hybrid	two-hybrid	JJ	JJ	_	5	amod	_	_
5	system	system	NN	NN	_	1	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	screen	screen	VB	VB	_	1	advcl	_	_
8	for	for	IN	IN	_	9	case	_	_
9	proteins	protein	NNS	NNS	_	7	nmod	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	interact	interact	VBP	VBP	_	9	acl:relcl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	Tax1	tax1	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	isolated	isolate	VBD	VBD	_	1	parataxis	_	_
17	the	the	DT	DT	_	19	det	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	subunit	subunit	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	CCAAT	ccaat	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	19	nmod	_	_
25	NF-Y	nf-y	NN	NN	_	24	dep	_	_
26	from	from	IN	IN	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	HeLa	hela	NN	NN	_	30	compound	_	_
29	cDNA	cdna	NN	NN	_	30	compound	_	_
30	library	library	NN	NN	_	16	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Tax1	tax1	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	NF-YB	nf-yb	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	specific	specific	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	14	mark	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	NF-YB	nf-yb	NN	NN	_	14	nsubj	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	interact	interact	VB	VB	_	8	advcl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	variety	variety	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	other	other	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	including	include	VBG	VBG	_	27	case	_	_
24	human	human	JJ	JJ	_	27	amod	_	_
25	immunodeficiency	immunodeficiency	NN	NN	_	27	compound	_	_
26	virus	virus	NN	NN	_	27	compound	_	_
27	Tat	tat	NN	NN	_	17	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	papillomavirus	papillomavirus	NN	NN	_	31	compound	_	_
31	E6	e6	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	Bicoid	bicoid	NN	NN	_	27	conj	_	_
35	,	,	,	,	_	17	punct	_	_
36	or	or	CC	CC	_	17	cc	_	_
37	with	with	IN	IN	_	46	case	_	_
38	the	the	DT	DT	_	46	det	_	_
39	M7	m7	NN	NN	_	46	compound	_	_
40	(	(	-LRB-	-LRB-	_	46	punct	_	_
41	amino	amino	NN	NN	_	46	compound	_	_
42	acids	acid	NNS	NNS	_	46	compound	_	_
43	29CP-AS	29cp-as	NN	NN	_	46	compound	_	_
44	)	)	-RRB-	-RRB-	_	46	punct	_	_
45	Tax1	tax1	NN	NN	_	46	compound	_	_
46	mutant	mutant	NN	NN	_	17	conj	_	_
47	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	NF-YB	nf-yb	NN	NN	_	5	nsubj	_	_
4	did	do	VBD	VBD	_	5	aux	_	_
5	interact	interact	VBP	VBP	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	C-terminal	c-terminal	JJ	JJ	_	10	amod	_	_
9	Tax1	tax1	NN	NN	_	10	compound	_	_
10	mutants	mutant	NNS	NNS	_	5	nmod	_	_
11	M22	m22	NN	NN	_	10	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	130TL-AS	130tl-as	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	M47	m47	NN	NN	_	11	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	319LL-RS	319ll-rs	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	in	in	FW	FW	_	6	dep	_	_
6	vitro-translated	vitro-translated	JJ	JJ	_	7	amod	_	_
7	NF-YB	nf-yb	NN	NN	_	9	nsubj	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	bound	bind	VBD	VBD	_	3	ccomp	_	_
10	to	to	TO	TO	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	glutathione	glutathione	NN	NN	_	15	compound	_	_
13	S-transferase-Tax1	s-transferase-tax1	NN	NN	_	15	compound	_	_
14	fusion	fusion	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Further	further	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Tax1	tax1	NN	NN	_	4	nsubj	_	_
4	coimmunoprecipitated	coimmunoprecipitate	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	NF-Y	nf-y	NN	NN	_	4	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	extracts	extract	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HTLV-1-transformed	htlv-1-transformed	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	providing	provide	VBG	VBG	_	4	xcomp	_	_
15	evidence	evidence	NN	NN	_	14	dobj	_	_
16	for	for	IN	IN	_	19	case	_	_
17	in	in	FW	FW	_	19	amod	_	_
18	vivo	vivo	FW	FW	_	17	dep	_	_
19	interaction	interaction	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Tax1	tax1	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	NF-YB	nf-yb	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Tax1	tax1	NN	NN	_	7	nsubj	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	activated	activate	VBD	VBD	_	3	ccomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	NF-Y-responsive	nf-y-responsive	JJ	JJ	_	11	amod	_	_
10	DQbeta	dqbeta	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	as	as	RB	RB	_	11	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	a	a	DT	DT	_	18	det	_	_
17	minimal	minimal	JJ	JJ	_	18	amod	_	_
18	promoter	promoter	NN	NN	_	11	conj	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	contains	contain	VBZ	VBZ	_	18	acl:relcl	_	_
21	only	only	RB	RB	_	24	advmod	_	_
22	the	the	DT	DT	_	24	det	_	_
23	Y-box	y-box	NN	NN	_	24	compound	_	_
24	element	element	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	mutation	mutation	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Y-box	y-box	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	4	nmod	_	_
9	alone	alone	RB	RB	_	4	advmod	_	_
10	abrogated	abrogate	VBD	VBD	_	0	root	_	_
11	Tax1-mediated	tax1-mediated	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	10	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	Tax1	tax1	NN	NN	_	9	nsubj	_	_
9	interacts	interact	VBZ	VBZ	_	6	ccomp	_	_
10	with	with	IN	IN	_	11	case	_	_
11	NF-Y	nf-y	NN	NN	_	9	nmod	_	_
12	through	through	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	subunit	subunit	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	this	this	DT	DT	_	19	det	_	_
19	interaction	interaction	NN	NN	_	20	nsubj	_	_
20	results	result	VBZ	VBZ	_	9	conj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	activation	activation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	major	major	JJ	JJ	_	30	amod	_	_
26	histocompatibility	histocompatibility	NN	NN	_	30	compound	_	_
27	complex	complex	NN	NN	_	30	compound	_	_
28	class	class	NN	NN	_	30	compound	_	_
29	II	ii	CD	CD	_	30	nummod	_	_
30	promoter	promoter	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	Through	through	IN	IN	_	2	case	_	_
2	activation	activation	NN	NN	_	15	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	this	this	DT	DT	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	NF-Y	nf-y	NN	NN	_	4	conj	_	_
8	driven	driven	JJ	JJ	_	7	amod	_	_
9	promoters	promoter	NNS	NNS	_	7	dep	_	_
10	,	,	,	,	_	15	punct	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Tax1-NF-Y	tax1-nf-y	NN	NN	_	13	compound	_	_
13	interaction	interaction	NN	NN	_	15	nsubj	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	play	play	VB	VB	_	0	root	_	_
16	a	a	DT	DT	_	18	det	_	_
17	critical	critical	JJ	JJ	_	18	amod	_	_
18	role	role	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	causing	cause	VBG	VBG	_	15	advcl	_	_
21	cellular	cellular	JJ	JJ	_	22	amod	_	_
22	transformation	transformation	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	HTLV-1	htlv-1	NN	NN	_	25	compound	_	_
25	pathogenesis	pathogenesis	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	15	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	novel	novel	JJ	JJ	_	9	amod	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	myeloid-cell-specific	myeloid-cell-specific	JJ	JJ	_	9	amod	_	_
7	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	9	compound	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Chicken	chicken	NN	NN	_	4	compound	_	_
2	NF-M	nf-m	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	15	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cooperation	cooperation	NN	NN	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	either	either	CC	CC	_	10	cc:preconj	_	_
10	c-Myb	c-myb	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	v-Myb	v-myb	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	4	punct	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	active	active	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	combinatorial	combinatorial	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	myeloid-cell-specific	myeloid-cell-specific	JJ	JJ	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	heterologous	heterologous	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	types	type	NNS	NNS	_	19	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	such	such	JJ	JJ	_	31	case	_	_
29	as	as	IN	IN	_	28	mwe	_	_
30	embryonic	embryonic	JJ	JJ	_	31	amod	_	_
31	fibroblasts	fibroblast	NNS	NNS	_	26	nmod	_	_
32	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	humans	human	NNS	NNS	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	similar	similar	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	homologous	homologous	JJ	JJ	_	10	amod	_	_
10	members	member	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	CCAAT/enhancer-binding	ccaat/enhancer-binding	JJ	JJ	_	18	amod	_	_
14	protein	protein	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	C/EBP	c/ebp	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	family	family	NN	NN	_	10	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	regulators	regulator	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	10	punct	_	_
23	especially	especially	RB	RB	_	26	advmod	_	_
24	the	the	DT	DT	_	26	det	_	_
25	human	human	JJ	JJ	_	26	amod	_	_
26	homolog	homolog	NN	NN	_	10	appos	_	_
27	of	of	IN	IN	_	29	case	_	_
28	chicken	chicken	NN	NN	_	29	compound	_	_
29	NF-M	nf-m	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	26	punct	_	_
31	C/EBP-beta	c/ebp-beta	NN	NN	_	26	appos	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	NF-IL6	nf-il6	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	NF-IL6	nf-il6	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	variety	variety	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	nonmyeloid	nonmyeloid	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	types	type	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	strongly	strongly	RB	RB	_	18	advmod	_	_
18	inducible	inducible	JJ	JJ	_	7	conj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	stimuli	stimulus	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	making	make	VBG	VBG	_	18	xcomp	_	_
26	it	it	PRP	PRP	_	29	nsubj	_	_
27	an	a	DT	DT	_	29	det	_	_
28	unlikely	unlikely	JJ	JJ	_	29	amod	_	_
29	candidate	candidate	NN	NN	_	25	xcomp	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	have	have	VB	VB	_	29	acl	_	_
32	an	a	DT	DT	_	34	det	_	_
33	exclusive	exclusive	JJ	JJ	_	34	amod	_	_
34	role	role	NN	NN	_	31	dobj	_	_
35	as	as	IN	IN	_	39	case	_	_
36	a	a	DT	DT	_	39	det	_	_
37	combinatorial	combinatorial	JJ	JJ	_	39	amod	_	_
38	differentiation	differentiation	NN	NN	_	39	compound	_	_
39	switch	switch	NN	NN	_	34	nmod	_	_
40	during	during	IN	IN	_	41	case	_	_
41	myelopoiesis	myelopoiesis	NN	NN	_	31	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	human	human	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	7	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	31	advcl	_	_
3	a	a	DT	DT	_	6	det	_	_
4	reverse	reverse	JJ	JJ	_	5	amod	_	_
5	transcription-PCR-based	transcription-pcr-based	JJ	JJ	_	6	amod	_	_
6	approach	approach	NN	NN	_	2	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	a	a	DT	DT	_	9	det	_	_
9	set	set	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	primers	primer	NNS	NNS	_	9	nmod	_	_
12	specific	specific	JJ	JJ	_	11	amod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	domains	domain	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	highly	highly	RB	RB	_	19	advmod	_	_
19	homologous	homologous	JJ	JJ	_	20	amod	_	_
20	members	member	NNS	NNS	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	C/EBP	c/ebp	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	transcriptional	transcriptional	JJ	JJ	_	27	amod	_	_
27	regulators	regulator	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	31	punct	_	_
29	we	we	PRP	PRP	_	31	nsubj	_	_
30	have	have	VBP	VBP	_	31	aux	_	_
31	cloned	clone	VBN	VBN	_	0	root	_	_
32	a	a	DT	DT	_	35	det	_	_
33	novel	novel	JJ	JJ	_	35	amod	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	gene	gene	NN	NN	_	31	dobj	_	_
36	encoding	encode	VBG	VBG	_	35	acl	_	_
37	a	a	DT	DT	_	38	det	_	_
38	member	member	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	43	case	_	_
40	the	the	DT	DT	_	43	det	_	_
41	C/EBP	c/ebp	NN	NN	_	43	compound	_	_
42	gene	gene	NN	NN	_	43	compound	_	_
43	family	family	NN	NN	_	38	nmod	_	_
44	,	,	,	,	_	35	punct	_	_
45	identified	identify	VBN	VBN	_	35	acl	_	_
46	as	as	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	human	human	JJ	JJ	_	49	amod	_	_
49	homolog	homolog	NN	NN	_	45	nmod	_	_
50	of	of	IN	IN	_	51	case	_	_
51	CRP1	crp1	NN	NN	_	49	nmod	_	_
52	,	,	,	,	_	49	punct	_	_
53	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	49	appos	_	_
54	.	.	.	.	_	31	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	1.2-kb	1.2-kb	JJ	JJ	_	3	amod	_	_
3	cDNA	cdna	NN	NN	_	9	nsubjpass	_	_
4	encoding	encode	VBG	VBG	_	3	acl	_	_
5	full-length	full-length	JJ	JJ	_	7	amod	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	4	dobj	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	cloned	clone	VBN	VBN	_	0	root	_	_
10	from	from	IN	IN	_	16	case	_	_
11	a	a	DT	DT	_	16	det	_	_
12	promyelocyte-late	promyelocyte-late	JJ	JJ	_	16	amod	_	_
13	myeloblast-derived	myeloblast-derived	JJ	JJ	_	16	amod	_	_
14	lambda	lambda	NN	NN	_	16	compound	_	_
15	gt11	gt11	NN	NN	_	16	compound	_	_
16	library	library	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	cDNA	cdna	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	genomic	genomic	JJ	JJ	_	5	conj	_	_
8	clones	clone	NNS	NNS	_	5	dep	_	_
9	indicated	indicate	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	presence	presence	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	exons	exon	NNS	NNS	_	11	nmod	_	_
15	encoding	encode	VBG	VBG	_	14	acl	_	_
16	a	a	DT	DT	_	17	det	_	_
17	protein	protein	NN	NN	_	15	dobj	_	_
18	with	with	IN	IN	_	22	case	_	_
19	an	a	DT	DT	_	22	det	_	_
20	apparent	apparent	JJ	JJ	_	22	amod	_	_
21	molecular	molecular	JJ	JJ	_	22	amod	_	_
22	mass	mass	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	32	32	CD	CD	_	25	nummod	_	_
25	kDa	kda	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	a	a	DT	DT	_	28	det	_	_
28	pI	pi	NN	NN	_	22	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	9.5	9.5	CD	CD	_	28	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Primer	primer	NN	NN	_	3	compound	_	_
2	extension	extension	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	3	nmod	_	_
7	detected	detect	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	13	det	_	_
9	single	single	JJ	JJ	_	13	amod	_	_
10	major	major	JJ	JJ	_	13	amod	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	start	start	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	7	dobj	_	_
14	approximately	approximately	RB	RB	_	15	advmod	_	_
15	200	200	CD	CD	_	16	nummod	_	_
16	bp	bp	NN	NN	_	17	nmod:npmod	_	_
17	upstream	upstream	RB	RB	_	13	advmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	start	start	NN	NN	_	21	compound	_	_
21	codon	codon	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	putative	putative	JJ	JJ	_	4	amod	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	area	area	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	similar	similar	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	those	those	DT	DT	_	6	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	several	several	JJ	JJ	_	12	amod	_	_
11	other	other	JJ	JJ	_	12	amod	_	_
12	myeloid-cell-specific	myeloid-cell-specific	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	17	mark	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	it	it	PRP	PRP	_	17	nsubj	_	_
17	contains	contain	VBZ	VBZ	_	6	advcl	_	_
18	no	no	DT	DT	_	20	neg	_	_
19	TATAAA	tataaa	NN	NN	_	20	compound	_	_
20	box	box	NN	NN	_	17	dobj	_	_
21	but	but	CC	CC	_	17	cc	_	_
22	has	have	VBZ	VBZ	_	17	conj	_	_
23	a	a	DT	DT	_	24	det	_	_
24	number	number	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	purine-rich	purine-rich	JJ	JJ	_	27	amod	_	_
27	stretches	stretch	NNS	NNS	_	24	nmod	_	_
28	with	with	IN	IN	_	30	case	_	_
29	multiple	multiple	JJ	JJ	_	30	amod	_	_
30	sites	site	NNS	NNS	_	24	nmod	_	_
31	for	for	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	factors	factor	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	Ets	ets	NN	NN	_	37	compound	_	_
37	family	family	NN	NN	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
40	regulators	regulator	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	10	det	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	restricted	restricted	JJ	JJ	_	10	amod	_	_
8	mRNA	mrna	NN	NN	_	10	compound	_	_
9	expression	expression	NN	NN	_	10	compound	_	_
10	pattern	pattern	NN	NN	_	4	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	with	with	IN	IN	_	16	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	strongest	strongest	JJS	JJS	_	15	amod	_	_
15	expression	expression	NN	NN	_	16	nsubj	_	_
16	occurring	occur	VBG	VBG	_	10	acl	_	_
17	in	in	IN	IN	_	18	case	_	_
18	promyelocyte	promyelocyte	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	late-myeloblast-like	late-myeloblast-like	JJ	JJ	_	18	conj	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	4	punct	_	_

1	Western	western	NN	NN	_	2	compound	_	_
2	blot	blot	NN	NN	_	24	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	immunoprecipitation	immunoprecipitation	NN	NN	_	2	conj	_	_
5	studies	study	NNS	NNS	_	2	dep	_	_
6	using	use	VBG	VBG	_	2	acl	_	_
7	rabbit	rabbit	NN	NN	_	9	compound	_	_
8	anti-C/EBP-epsilon	anti-c/ebp-epsilon	JJ	JJ	_	9	amod	_	_
9	antibodies	antibody	NNS	NNS	_	6	dobj	_	_
10	raised	raise	VBN	VBN	_	9	acl	_	_
11	against	against	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	N-terminal	n-terminal	JJ	JJ	_	14	amod	_	_
14	portion	portion	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	amino	amino	NN	NN	_	19	compound	_	_
19	acids	acid	NNS	NNS	_	14	appos	_	_
20	1	1	CD	CD	_	19	nummod	_	_
21	to	to	TO	TO	_	19	dep	_	_
22	115	115	CD	CD	_	19	nummod	_	_
23	)	)	-RRB-	-RRB-	_	19	punct	_	_
24	showed	show	VBD	VBD	_	0	root	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	31	nsubj	_	_
27	is	be	VBZ	VBZ	_	31	cop	_	_
28	a	a	DT	DT	_	31	det	_	_
29	32-kDa	32-kda	JJ	JJ	_	31	amod	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	phosphoprotein	phosphoprotein	NN	NN	_	24	ccomp	_	_
32	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	5	nsubj	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	strong	strong	JJ	JJ	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	specific	specific	JJ	JJ	_	6	conj	_	_
9	binding	binding	NN	NN	_	5	dobj	_	_
10	to	to	TO	TO	_	16	case	_	_
11	double-stranded	double-stranded	JJ	JJ	_	16	amod	_	_
12	DNA	dna	NN	NN	_	16	compound	_	_
13	containing	contain	VBG	VBG	_	16	amod	_	_
14	consensus	consensus	NN	NN	_	16	compound	_	_
15	C/EBP	c/ebp	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	23	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	1	nmod	_	_
5	sense	sense	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	antisense	antisense	JJ	JJ	_	4	conj	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	constructs	construct	NNS	NNS	_	4	dep	_	_
10	together	together	RB	RB	_	15	advmod	_	_
11	with	with	IN	IN	_	15	case	_	_
12	chloramphenicol	chloramphenicol	NN	NN	_	15	compound	_	_
13	acetyltransferase	acetyltransferase	NN	NN	_	15	compound	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	vectors	vector	NNS	NNS	_	1	nmod	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	myeloid-cell-specific	myeloid-cell-specific	JJ	JJ	_	18	amod	_	_
18	c-mim	c-mim	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	myeloperoxidase	myeloperoxidase	JJ	JJ	_	18	conj	_	_
22	promoters	promoter	NNS	NNS	_	18	dep	_	_
23	suggested	suggest	VBD	VBD	_	0	root	_	_
24	a	a	DT	DT	_	25	det	_	_
25	role	role	NN	NN	_	23	dobj	_	_
26	for	for	IN	IN	_	27	case	_	_
27	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	25	nmod	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	27	dep	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	regulation	regulation	NN	NN	_	25	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	a	a	DT	DT	_	35	det	_	_
35	subset	subset	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	myeloid-cell-specific	myeloid-cell-specific	JJ	JJ	_	38	amod	_	_
38	genes	gene	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	23	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	tranfection	tranfection	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	promyelocyte	promyelocyte	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NB4	nb4	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	with	with	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	15	compound	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	plasmid	plasmid	NN	NN	_	2	nmod	_	_
16	increased	increase	VBD	VBD	_	0	root	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	growth	growth	NN	NN	_	16	dobj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	sevenfold	sevenfold	RB	RB	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	while	while	IN	IN	_	25	mark	_	_
23	antisense	antisense	JJ	JJ	_	24	amod	_	_
24	C/EBP-epsilon	c/ebp-epsilon	NN	NN	_	25	nsubj	_	_
25	caused	cause	VBD	VBD	_	16	advcl	_	_
26	a	a	DT	DT	_	28	det	_	_
27	fivefold	fivefold	JJ	JJ	_	28	amod	_	_
28	decrease	decrease	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	clonal	clonal	JJ	JJ	_	31	amod	_	_
31	growth	growth	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	these	these	DT	DT	_	34	det	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	16	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	ferritin	ferritin	NN	NN	_	7	compound	_	_
6	heavy-chain	heavy-chain	JJ	JJ	_	7	amod	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	:	:	:	:	_	2	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activity	activity	NN	NN	_	18	nsubjpass	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	CCAAT	ccaat	NN	NN	_	16	compound	_	_
14	binding	binding	NN	NN	_	16	compound	_	_
15	factor	factor	NN	NN	_	16	compound	_	_
16	NF-Y	nf-y	NN	NN	_	10	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	modulated	modulate	VBN	VBN	_	2	dep	_	_
19	in	in	IN	IN	_	23	case	_	_
20	heme-treated	heme-treated	JJ	JJ	_	23	amod	_	_
21	Friend	friend	NN	NN	_	23	compound	_	_
22	leukemia	leukemia	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	during	during	IN	IN	_	27	case	_	_
26	monocyte-to-macrophage	monocyte-to-macrophage	JJ	JJ	_	27	amod	_	_
27	differentiation	differentiation	NN	NN	_	23	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	ferritin	ferritin	NN	NN	_	5	compound	_	_
3	H-chain	h-chain	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	regulation	regulation	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	analyzed	analyze	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	heme-treated	heme-treated	JJ	JJ	_	13	amod	_	_
11	Friend	friend	NN	NN	_	13	compound	_	_
12	leukemia	leukemia	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	FLCs	flc	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	during	during	IN	IN	_	20	case	_	_
19	monocyte-to-macrophage	monocyte-to-macrophage	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	13	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	majority	majority	NN	NN	_	15	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	3	nmod	_	_
7	studied	study	VBN	VBN	_	6	acl	_	_
8	,	,	,	,	_	15	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	15	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	ferritin	ferritin	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	exerted	exert	VBN	VBN	_	0	root	_	_
16	mostly	mostly	RB	RB	_	20	advmod	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	translational	translational	JJ	JJ	_	20	amod	_	_
20	level	level	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	However	however	RB	RB	_	33	advmod	_	_
2	,	,	,	,	_	33	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	differentiating	differentiate	VBG	VBG	_	6	amod	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	33	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	which	which	WDT	WDT	_	10	nsubj	_	_
9	must	must	MD	MD	_	10	aux	_	_
10	incorporate	incorporate	VB	VB	_	6	acl:relcl	_	_
11	high	high	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	iron	iron	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	sustain	sustain	VB	VB	_	10	xcomp	_	_
17	hemoglobin	hemoglobin	NN	NN	_	18	compound	_	_
18	synthesis	synthesis	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	6	punct	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	in	in	IN	IN	_	22	case	_	_
22	macrophages	macrophage	NNS	NNS	_	6	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	26	nsubjpass	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	involved	involve	VBN	VBN	_	22	acl:relcl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	iron	iron	NN	NN	_	29	compound	_	_
29	storage	storage	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	33	punct	_	_
31	transcriptional	transcriptional	JJ	JJ	_	32	amod	_	_
32	regulation	regulation	NN	NN	_	33	nsubj	_	_
33	seemed	seem	VBD	VBD	_	0	root	_	_
34	to	to	TO	TO	_	38	mark	_	_
35	be	be	VB	VB	_	38	cop	_	_
36	a	a	DT	DT	_	38	det	_	_
37	relevant	relevant	JJ	JJ	_	38	amod	_	_
38	mechanism	mechanism	NN	NN	_	33	xcomp	_	_
39	.	.	.	.	_	33	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	30	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	minimum	minimum	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	30	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	ferritin	ferritin	NN	NN	_	12	compound	_	_
11	H-gene	h-gene	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	7	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	able	able	JJ	JJ	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	confer	confer	VB	VB	_	15	xcomp	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	regulation	regulation	NN	NN	_	17	dobj	_	_
20	by	by	IN	IN	_	21	case	_	_
21	heme	heme	NN	NN	_	17	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	FLCs	flc	NNS	NNS	_	21	nmod	_	_
24	to	to	TO	TO	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	reporter	reporter	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	17	nmod	_	_
28	is	be	VBZ	VBZ	_	30	cop	_	_
29	77	77	CD	CD	_	30	nummod	_	_
30	nucleotides	nucleotide	NNS	NNS	_	2	ccomp	_	_
31	upstream	upstream	JJ	JJ	_	30	amod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	TATA	tata	NN	NN	_	35	compound	_	_
35	box	box	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cis	cis	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	4	nsubj	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	4	dobj	_	_
8	referred	refer	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	8	nmod	_	_
10	as	as	IN	IN	_	11	case	_	_
11	HRF	hrf	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	heme-responsive	heme-responsive	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	11	punct	_	_
17	which	which	WDT	WDT	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	greatly	greatly	RB	RB	_	20	advmod	_	_
20	enhanced	enhance	VBN	VBN	_	11	acl:relcl	_	_
21	both	both	CC	CC	_	24	cc:preconj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	heme-treated	heme-treated	JJ	JJ	_	24	amod	_	_
24	FLCs	flc	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	during	during	IN	IN	_	28	case	_	_
27	monocyte-to-macrophage	monocyte-to-macrophage	JJ	JJ	_	28	amod	_	_
28	differentiation	differentiation	NN	NN	_	24	conj	_	_
29	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CCAAT	ccaat	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	18	nsubj	_	_
4	present	present	JJ	JJ	_	3	amod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	reverse	reverse	JJ	JJ	_	7	amod	_	_
7	orientation	orientation	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	this	this	DT	DT	_	11	det	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	ferritin	ferritin	NN	NN	_	16	compound	_	_
15	H-chain	h-chain	JJ	JJ	_	16	amod	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	necessary	necessary	JJ	JJ	_	0	root	_	_
19	for	for	IN	IN	_	20	case	_	_
20	binding	binding	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	for	for	IN	IN	_	24	case	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	18	punct	_	_
26	since	since	IN	IN	_	32	mark	_	_
27	a	a	DT	DT	_	30	det	_	_
28	single	single	JJ	JJ	_	30	amod	_	_
29	point	point	NN	NN	_	30	compound	_	_
30	mutation	mutation	NN	NN	_	32	nsubj	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	able	able	JJ	JJ	_	18	advcl	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	abolish	abolish	VB	VB	_	32	xcomp	_	_
35	the	the	DT	DT	_	36	det	_	_
36	binding	binding	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	HRF	hrf	NN	NN	_	36	nmod	_	_
39	and	and	CC	CC	_	36	cc	_	_
40	the	the	DT	DT	_	42	det	_	_
41	transcriptional	transcriptional	JJ	JJ	_	42	amod	_	_
42	activity	activity	NN	NN	_	36	conj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	transfected	transfect	VBN	VBN	_	45	amod	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	18	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	competition	competition	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	9	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	supershift	supershift	NN	NN	_	6	compound	_	_
6	assays	assay	NNS	NNS	_	3	conj	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	identified	identify	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	induced	induce	VBN	VBN	_	12	amod	_	_
12	HRF	hrf	NN	NN	_	9	dobj	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	containing	contain	VBG	VBG	_	9	advcl	_	_
15	at	at	IN	IN	_	16	case	_	_
16	least	least	JJS	JJS	_	20	advmod	_	_
17	the	the	DT	DT	_	20	det	_	_
18	ubiquitous	ubiquitous	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	14	dobj	_	_
21	NF-Y	nf-y	NN	NN	_	20	dep	_	_
22	.	.	.	.	_	9	punct	_	_

1	NF-Y	nf-y	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	formed	form	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	three	three	CD	CD	_	6	nummod	_	_
6	subunits	subunit	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	A	a	DT	DT	_	6	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	B	b	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	C	c	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	all	all	DT	DT	_	19	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	15	nmod	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	necessary	necessary	JJ	JJ	_	6	acl:relcl	_	_
20	for	for	IN	IN	_	22	case	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	11	nsubj	_	_
2	with	with	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	transdominant	transdominant	JJ	JJ	_	6	amod	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	mutant	mutant	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	NF-YA	nf-ya	NN	NN	_	10	compound	_	_
10	subunit	subunit	NN	NN	_	6	nmod	_	_
11	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	11	dobj	_	_
15	by	by	IN	IN	_	16	case	_	_
16	heme	heme	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	indicating	indicate	VBG	VBG	_	11	advcl	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	NF-Y	nf-y	NN	NN	_	21	nsubj	_	_
21	plays	play	VBZ	VBZ	_	18	ccomp	_	_
22	an	a	DT	DT	_	24	det	_	_
23	essential	essential	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	differential	differential	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	NF-YA	nf-ya	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	heme-treated	heme-treated	JJ	JJ	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	control	control	JJ	JJ	_	13	conj	_	_
16	FLCs	flc	NNS	NNS	_	13	dep	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	during	during	IN	IN	_	20	case	_	_
19	monocyte-to-macrophage	monocyte-to-macrophage	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	13	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	mutant	mutant	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	1	nmod	_	_
7	that	that	WDT	WDT	_	10	nsubj	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	activate	activate	VB	VB	_	6	acl:relcl	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	response	response	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	multiple	multiple	JJ	JJ	_	16	amod	_	_
16	stimuli	stimulus	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Numerous	numerous	JJ	JJ	_	2	amod	_	_
2	genes	gene	NNS	NNS	_	17	nsubjpass	_	_
3	required	require	VBN	VBN	_	2	acl	_	_
4	during	during	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	immune	immune	JJ	JJ	_	3	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	inflammation	inflammation	NN	NN	_	6	conj	_	_
9	response	response	NN	NN	_	6	dep	_	_
10	as	as	RB	RB	_	6	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	the	the	DT	DT	_	15	det	_	_
14	adhesion	adhesion	NN	NN	_	15	compound	_	_
15	process	process	NN	NN	_	6	conj	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	regulated	regulate	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	21	case	_	_
19	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	kappaB	kappab	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	17	punct	_	_

1	Associated	associate	VBN	VBN	_	0	root	_	_
2	with	with	IN	IN	_	4	case	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	inhibitor	inhibitor	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	I	i	NN	NN	_	7	compound	_	_
7	kappaB	kappab	NN	NN	_	4	appos	_	_
8	,	,	,	,	_	1	punct	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	nsubj	_	_
10	resides	reside	VBZ	VBZ	_	1	parataxis	_	_
11	as	as	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	inactive	inactive	JJ	JJ	_	14	amod	_	_
14	form	form	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	10	nmod	_	_
3	by	by	IN	IN	_	5	case	_	_
4	various	various	JJ	JJ	_	5	amod	_	_
5	agents	agent	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	I	i	NN	NN	_	8	compound	_	_
8	kappaB	kappab	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	proteolyzed	proteolyze	VBN	VBN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	nsubj	_	_
13	translocates	translocate	VBZ	VBZ	_	10	conj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nucleus	nucleus	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	where	where	WRB	WRB	_	20	advmod	_	_
19	it	it	PRP	PRP	_	20	nsubj	_	_
20	activates	activate	VBZ	VBZ	_	16	acl:relcl	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	target	target	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transduction	transduction	NN	NN	_	3	compound	_	_
3	pathways	pathway	NNS	NNS	_	10	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	lead	lead	VBP	VBP	_	3	acl:relcl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	I	i	NN	NN	_	8	compound	_	_
8	kappaB	kappab	NN	NN	_	9	compound	_	_
9	inactivation	inactivation	NN	NN	_	5	nmod	_	_
10	remain	remain	VBP	VBP	_	0	root	_	_
11	poorly	poorly	RB	RB	_	10	advmod	_	_
12	understood	understand	VBN	VBN	_	10	xcomp	_	_
13	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	characterized	characterize	VBN	VBN	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	mutant	mutant	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	the	the	DT	DT	_	18	det	_	_
13	70/Z3-derived	70/z3-derived	JJ	JJ	_	18	amod	_	_
14	1.3E2	1.3e2	NN	NN	_	18	compound	_	_
15	murine	murine	JJ	JJ	_	18	amod	_	_
16	pre-B	pre-b	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	10	appos	_	_
19	,	,	,	,	_	10	punct	_	_
20	that	that	WDT	WDT	_	23	nsubj	_	_
21	does	do	VBZ	VBZ	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	activate	activate	VB	VB	_	10	acl:relcl	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	23	dobj	_	_
25	in	in	IN	IN	_	26	case	_	_
26	response	response	NN	NN	_	23	nmod	_	_
27	to	to	TO	TO	_	29	case	_	_
28	several	several	JJ	JJ	_	29	amod	_	_
29	stimuli	stimulus	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	26	mark	_	_
4	upon	upon	IN	IN	_	5	case	_	_
5	stimulation	stimulation	NN	NN	_	26	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	Taxol	taxol	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	phorbol	phorbol	NN	NN	_	13	compound	_	_
12	myristate	myristate	NN	NN	_	13	compound	_	_
13	acetate	acetate	NN	NN	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	interleukin-1	interleukin-1	NN	NN	_	7	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	or	or	CC	CC	_	7	cc	_	_
18	double-stranded	double-stranded	JJ	JJ	_	19	amod	_	_
19	RNA	rna	NN	NN	_	7	conj	_	_
20	,	,	,	,	_	26	punct	_	_
21	I	i	NN	NN	_	23	compound	_	_
22	kappaB	kappab	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	26	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	26	auxpass	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	degraded	degrade	VBN	VBN	_	2	ccomp	_	_
27	,	,	,	,	_	26	punct	_	_
28	as	as	IN	IN	_	30	case	_	_
29	a	a	DT	DT	_	30	det	_	_
30	result	result	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	an	a	DT	DT	_	33	det	_	_
33	absence	absence	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	induced	induce	VBN	VBN	_	36	amod	_	_
36	phosphorylation	phosphorylation	NN	NN	_	33	nmod	_	_
37	on	on	IN	IN	_	38	case	_	_
38	serines	serine	NNS	NNS	_	36	nmod	_	_
39	32	32	CD	CD	_	38	dep	_	_
40	and	and	CC	CC	_	38	cc	_	_
41	36	36	CD	CD	_	38	conj	_	_
42	.	.	.	.	_	2	punct	_	_

1	Neither	neither	CC	CC	_	3	cc:preconj	_	_
2	a	a	DT	DT	_	3	det	_	_
3	mutation	mutation	NN	NN	_	27	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	I	i	NN	NN	_	7	compound	_	_
6	kappaB	kappab	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	3	nmod	_	_
8	nor	nor	CC	CC	_	3	cc	_	_
9	a	a	DT	DT	_	10	det	_	_
10	mutation	mutation	NN	NN	_	3	conj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	p50	p50	NN	NN	_	10	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	relA	rela	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	the	the	DT	DT	_	19	det	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	major	major	JJ	JJ	_	19	amod	_	_
19	subunits	subunit	NNS	NNS	_	12	appos	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	this	this	DT	DT	_	25	det	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	3	punct	_	_
27	accounts	account	VBZ	VBZ	_	0	root	_	_
28	for	for	IN	IN	_	31	case	_	_
29	this	this	DT	DT	_	31	det	_	_
30	phosphorylation	phosphorylation	NN	NN	_	31	compound	_	_
31	defect	defect	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	27	punct	_	_

1	As	as	RB	RB	_	4	advmod	_	_
2	well	well	RB	RB	_	4	advmod	_	_
3	as	as	IN	IN	_	4	mark	_	_
4	culminating	culminate	VBG	VBG	_	28	dep	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	inducible	inducible	JJ	JJ	_	8	amod	_	_
8	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	I	i	NN	NN	_	11	compound	_	_
11	kappaB	kappab	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	8	nmod	_	_
13	on	on	IN	IN	_	14	case	_	_
14	serines	serine	NNS	NNS	_	8	nmod	_	_
15	32	32	CD	CD	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	36	36	CD	CD	_	14	conj	_	_
18	,	,	,	,	_	28	punct	_	_
19	all	all	PDT	PDT	_	21	det:predet	_	_
20	the	the	DT	DT	_	21	det	_	_
21	stimuli	stimulus	NNS	NNS	_	28	nsubj	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	are	be	VBP	VBP	_	24	cop	_	_
24	inactive	inactive	JJ	JJ	_	21	acl:relcl	_	_
25	on	on	IN	IN	_	27	case	_	_
26	1.3E2	1.3e2	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	exhibit	exhibit	VBP	VBP	_	0	root	_	_
29	a	a	DT	DT	_	30	det	_	_
30	sensitivity	sensitivity	NN	NN	_	28	dobj	_	_
31	to	to	TO	TO	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	antioxidant	antioxidant	JJ	JJ	_	30	nmod	_	_
34	pyrrolidine	pyrrolidine	NN	NN	_	35	compound	_	_
35	dithiocarbamate	dithiocarbamate	NN	NN	_	33	dep	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	PDTC	pdtc	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	28	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	stimuli	stimulus	NNS	NNS	_	18	nsubj	_	_
5	such	such	JJ	JJ	_	8	case	_	_
6	as	as	IN	IN	_	5	mwe	_	_
7	hyperosmotic	hyperosmotic	JJ	JJ	_	8	amod	_	_
8	shock	shock	NN	NN	_	4	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	phosphatase	phosphatase	NN	NN	_	11	compound	_	_
11	inhibitors	inhibitor	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	use	use	VBP	VBP	_	8	acl:relcl	_	_
15	PDTC-insensitive	pdtc-insensitive	JJ	JJ	_	16	amod	_	_
16	pathways	pathway	NNS	NNS	_	14	dobj	_	_
17	,	,	,	,	_	4	punct	_	_
18	induce	induce	VBP	VBP	_	0	root	_	_
19	I	i	NN	NN	_	20	compound	_	_
20	kappaB	kappab	NN	NN	_	22	compound	_	_
21	alpha	alpha	NN	NN	_	22	compound	_	_
22	degradation	degradation	NN	NN	_	18	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	1.3E2	1.3e2	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	18	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	redox	redox	JJ	JJ	_	5	amod	_	_
5	status	status	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	1.3E2	1.3e2	NN	NN	_	5	nmod	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	reveal	reveal	VB	VB	_	0	root	_	_
11	any	any	DT	DT	_	12	det	_	_
12	difference	difference	NN	NN	_	10	dobj	_	_
13	from	from	IN	IN	_	15	case	_	_
14	wild-type	wild-type	JJ	JJ	_	15	amod	_	_
15	70Z/3	70z/3	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	17	det	_	_
6	human	human	JJ	JJ	_	17	amod	_	_
7	T-cell	t-cell	NN	NN	_	17	compound	_	_
8	leukemia	leukemia	NN	NN	_	17	compound	_	_
9	virus	virus	NN	NN	_	17	compound	_	_
10	type	type	NN	NN	_	17	compound	_	_
11	1	1	CD	CD	_	17	nummod	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	HTLV-1	htlv-1	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	-derived	-derived	JJ	JJ	_	17	amod	_	_
16	Tax	tax	NN	NN	_	17	compound	_	_
17	trans-activator	trans-activator	NN	NN	_	18	nsubj	_	_
18	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	1.3E2	1.3e2	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	18	punct	_	_
24	suggesting	suggest	VBG	VBG	_	18	advcl	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	this	this	DT	DT	_	28	det	_	_
27	viral	viral	JJ	JJ	_	28	amod	_	_
28	protein	protein	NN	NN	_	31	nsubj	_	_
29	does	do	VBZ	VBZ	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	operate	operate	VB	VB	_	24	ccomp	_	_
32	via	via	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	defective	defective	JJ	JJ	_	35	amod	_	_
35	pathway	pathway	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	25	mark	_	_
6	two	two	CD	CD	_	10	nummod	_	_
7	other	other	JJ	JJ	_	10	amod	_	_
8	I	i	NN	NN	_	10	compound	_	_
9	kappaB	kappab	NN	NN	_	10	compound	_	_
10	molecules	molecule	NNS	NNS	_	25	nsubjpass	_	_
11	,	,	,	,	_	10	punct	_	_
12	I	i	NN	NN	_	14	compound	_	_
13	kappaB	kappab	NN	NN	_	14	compound	_	_
14	beta	beta	NN	NN	_	10	appos	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	21	det	_	_
17	recently	recently	RB	RB	_	18	advmod	_	_
18	identified	identify	VBN	VBN	_	21	amod	_	_
19	I	i	NN	NN	_	21	compound	_	_
20	kappaB	kappab	NN	NN	_	21	compound	_	_
21	epsilon	epsilon	NN	NN	_	14	conj	_	_
22	,	,	,	,	_	10	punct	_	_
23	are	be	VBP	VBP	_	25	auxpass	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	degraded	degrade	VBN	VBN	_	4	ccomp	_	_
26	in	in	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	1.3E2	1.3e2	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	line	line	NN	NN	_	25	nmod	_	_
31	following	follow	VBG	VBG	_	32	case	_	_
32	stimulation	stimulation	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	1.3E2	1.3e2	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	cellular	cellular	JJ	JJ	_	10	amod	_	_
9	transduction	transduction	NN	NN	_	10	compound	_	_
10	mutant	mutant	NN	NN	_	3	ccomp	_	_
11	exhibiting	exhibit	VBG	VBG	_	10	acl	_	_
12	a	a	DT	DT	_	13	det	_	_
13	defect	defect	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	step	step	NN	NN	_	11	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	16	acl:relcl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	different	different	JJ	JJ	_	23	amod	_	_
23	stimuli	stimulus	NNS	NNS	_	19	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	activate	activate	VB	VB	_	19	xcomp	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	analysis	analysis	NN	NN	_	6	nsubj	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	common	common	JJ	JJ	_	9	amod	_	_
9	step	step	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	trigger	trigger	VBP	VBP	_	13	acl:relcl	_	_
16	I	i	NN	NN	_	18	compound	_	_
17	kappaB	kappab	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	I	i	NN	NN	_	22	compound	_	_
21	kappaB	kappab	NN	NN	_	22	compound	_	_
22	beta	beta	NN	NN	_	18	conj	_	_
23	,	,	,	,	_	18	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	I	i	NN	NN	_	27	compound	_	_
26	kappaB	kappab	NN	NN	_	27	compound	_	_
27	epsilon	epsilon	NN	NN	_	18	conj	_	_
28	degradation	degradation	NN	NN	_	18	dep	_	_
29	.	.	.	.	_	6	punct	_	_

1	Transcription	transcription	NN	NN	_	7	nsubj	_	_
2	mediated	mediate	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	4	case	_	_
4	NFAT	nfat	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	inducible	inducible	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	effector	effector	NN	NN	_	7	nmod	_	_
10	CD4+	cd4+	JJ	JJ	_	17	amod	_	_
11	T	t	NN	NN	_	17	compound	_	_
12	helper	helper	NN	NN	_	17	compound	_	_
13	2	2	CD	CD	_	17	nummod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	Th2	th2	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	cells	cell	NNS	NNS	_	9	dep	_	_
18	but	but	CC	CC	_	9	cc	_	_
19	not	not	RB	RB	_	22	neg	_	_
20	in	in	IN	IN	_	22	case	_	_
21	Th1	th1	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	9	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	NFAT	nfat	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	play	play	VBP	VBP	_	0	root	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	regulating	regulate	VBG	VBG	_	7	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	several	several	JJ	JJ	_	18	amod	_	_
17	cytokine	cytokine	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	14	nmod	_	_
19	during	during	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	immune	immune	JJ	JJ	_	22	amod	_	_
22	response	response	NN	NN	_	14	nmod	_	_
23	,	,	,	,	_	7	punct	_	_
24	such	such	JJ	JJ	_	27	case	_	_
25	as	as	IN	IN	_	24	mwe	_	_
26	the	the	DT	DT	_	27	det	_	_
27	genes	gene	NNS	NNS	_	7	nmod	_	_
28	for	for	IN	IN	_	29	case	_	_
29	interleukin	interleukin	NN	NN	_	27	nmod	_	_
30	2	2	CD	CD	_	29	nummod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	IL-2	il-2	NN	NN	_	29	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	IL-4	il-4	NN	NN	_	29	conj	_	_
36	,	,	,	,	_	27	punct	_	_
37	among	among	IN	IN	_	38	case	_	_
38	others	other	NNS	NNS	_	27	nmod	_	_
39	.	.	.	.	_	7	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	antigen	antigen	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	precursor	precursor	NN	NN	_	13	nsubj	_	_
6	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
7	T	t	NN	NN	_	12	compound	_	_
8	helper	helper	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	pTh	pth	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	cells	cell	NNS	NNS	_	5	dep	_	_
13	proliferate	proliferate	VBP	VBP	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	differentiate	differentiate	VBP	VBP	_	13	conj	_	_
16	into	into	IN	IN	_	18	case	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	populations	population	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	effector	effector	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	eTh1	eth1	NN	NN	_	18	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	eTh2	eth2	NN	NN	_	23	conj	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	,	,	,	,	_	15	punct	_	_
28	each	each	DT	DT	_	29	det	_	_
29	one	one	NN	NN	_	30	nsubj	_	_
30	expressing	express	VBG	VBG	_	15	dep	_	_
31	a	a	DT	DT	_	33	det	_	_
32	specific	specific	JJ	JJ	_	33	amod	_	_
33	pattern	pattern	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	cytokines	cytokine	NNS	NNS	_	33	nmod	_	_
36	that	that	WDT	WDT	_	37	nsubj	_	_
37	distinguishes	distinguish	VBZ	VBZ	_	33	acl:relcl	_	_
38	them	they	PRP	PRP	_	37	dobj	_	_
39	from	from	IN	IN	_	41	case	_	_
40	their	they	PRP$	PRP$	_	41	nmod:poss	_	_
41	precursors	precursor	NNS	NNS	_	37	nmod	_	_
42	.	.	.	.	_	13	punct	_	_

1	eTh2	eth2	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	major	major	JJ	JJ	_	6	amod	_	_
6	source	source	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-4	il-4	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	while	while	IN	IN	_	14	mark	_	_
11	gamma	gamma	NN	NN	_	12	compound	_	_
12	interferon	interferon	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	produced	produce	VBN	VBN	_	6	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	eTh1	eth1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	we	we	PRP	PRP	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	reporter	reporter	NN	NN	_	7	compound	_	_
6	transgenic	transgenic	JJ	JJ	_	7	amod	_	_
7	mice	mouse	NNS	NNS	_	4	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	show	show	VB	VB	_	4	xcomp	_	_
10	that	that	IN	IN	_	20	mark	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	20	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activities	activity	NNS	NNS	_	12	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NFAT	nfat	NN	NN	_	15	nmod	_	_
18	are	be	VBP	VBP	_	20	auxpass	_	_
19	transiently	transiently	RB	RB	_	20	advmod	_	_
20	induced	induce	VBN	VBN	_	9	ccomp	_	_
21	during	during	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	pTh	pth	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	into	into	IN	IN	_	29	case	_	_
28	either	either	CC	CC	_	29	cc:preconj	_	_
29	eTh1	eth1	NN	NN	_	23	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	eTh2	eth2	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	conj	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	mediate	mediate	VB	VB	_	20	xcomp	_	_
35	the	the	DT	DT	_	36	det	_	_
36	expression	expression	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	IL-2	il-2	NN	NN	_	36	nmod	_	_
39	as	as	IN	IN	_	43	case	_	_
40	a	a	DT	DT	_	43	det	_	_
41	common	common	JJ	JJ	_	43	amod	_	_
42	growth	growth	NN	NN	_	43	compound	_	_
43	factor	factor	NN	NN	_	34	nmod	_	_
44	in	in	IN	IN	_	46	case	_	_
45	both	both	CC	CC	_	46	dep	_	_
46	pathways	pathway	NNS	NNS	_	43	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	29	advmod	_	_
2	,	,	,	,	_	29	punct	_	_
3	although	although	IN	IN	_	9	mark	_	_
4	NFAT	nfat	NN	NN	_	6	compound	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	similarly	similarly	RB	RB	_	9	advmod	_	_
9	induced	induce	VBN	VBN	_	29	dep	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	eTh1	eth1	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	eTh2	eth2	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	upon	upon	IN	IN	_	18	case	_	_
17	antigen	antigen	NN	NN	_	18	compound	_	_
18	stimulation	stimulation	NN	NN	_	9	nmod	_	_
19	,	,	,	,	_	29	punct	_	_
20	only	only	RB	RB	_	23	advmod	_	_
21	the	the	DT	DT	_	23	det	_	_
22	NFAT	nfat	NN	NN	_	23	compound	_	_
23	complexes	complex	NNS	NNS	_	29	nsubj	_	_
24	present	present	JJ	JJ	_	23	amod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	eTh2	eth2	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	able	able	JJ	JJ	_	0	root	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	mediate	mediate	VB	VB	_	29	xcomp	_	_
32	high-level	high-level	JJ	JJ	_	33	amod	_	_
33	transcription	transcription	NN	NN	_	31	dobj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	relatively	relatively	RB	RB	_	37	advmod	_	_
37	little	little	JJ	JJ	_	40	amod	_	_
38	NFAT	nfat	NN	NN	_	40	compound	_	_
39	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
40	activity	activity	NN	NN	_	42	nsubjpass	_	_
41	was	be	VBD	VBD	_	42	auxpass	_	_
42	induced	induce	VBN	VBN	_	29	conj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	eTh1	eth1	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	29	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	pTh	pth	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	neither	neither	CC	CC	_	9	cc:preconj	_	_
9	eTh1	eth1	NN	NN	_	13	nsubj	_	_
10	nor	nor	CC	CC	_	9	cc	_	_
11	eTh2	eth2	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	produced	produce	VBD	VBD	_	0	root	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	IL-2	il-2	NN	NN	_	13	dobj	_	_
16	upon	upon	IN	IN	_	17	case	_	_
17	stimulation	stimulation	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	but	but	CC	CC	_	13	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	high	high	JJ	JJ	_	22	amod	_	_
22	levels	level	NNS	NNS	_	28	nsubj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NFAT	nfat	NN	NN	_	26	compound	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activities	activity	NNS	NNS	_	22	nmod	_	_
27	directly	directly	RB	RB	_	28	advmod	_	_
28	correlate	correlate	VBP	VBP	_	13	conj	_	_
29	with	with	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	IL-4	il-4	NN	NN	_	32	compound	_	_
32	production	production	NN	NN	_	28	nmod	_	_
33	induced	induce	VBN	VBN	_	32	acl	_	_
34	in	in	IN	IN	_	35	case	_	_
35	response	response	NN	NN	_	33	nmod	_	_
36	to	to	TO	TO	_	38	case	_	_
37	antigen	antigen	NN	NN	_	38	compound	_	_
38	stimulation	stimulation	NN	NN	_	35	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	eTh2	eth2	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	NFAT	nfat	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	3	ccomp	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	effector	effector	NN	NN	_	12	compound	_	_
12	function	function	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	eTh2	eth2	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	that	that	IN	IN	_	32	mark	_	_
18	the	the	DT	DT	_	19	det	_	_
19	failure	failure	NN	NN	_	32	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	eTh1	eth1	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	produce	produce	VB	VB	_	19	acl	_	_
25	IL-4	il-4	NN	NN	_	24	dobj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	response	response	NN	NN	_	24	nmod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	an	a	DT	DT	_	30	det	_	_
30	antigen	antigen	NN	NN	_	27	nmod	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	due	due	JJ	JJ	_	8	conj	_	_
33	,	,	,	,	_	32	punct	_	_
34	at	at	IN	IN	_	36	advmod	_	_
35	least	least	JJS	JJS	_	34	mwe	_	_
36	partially	partially	RB	RB	_	32	advmod	_	_
37	,	,	,	,	_	32	punct	_	_
38	to	to	TO	TO	_	40	case	_	_
39	a	a	DT	DT	_	40	det	_	_
40	failure	failure	NN	NN	_	32	nmod	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	induce	induce	VB	VB	_	40	acl	_	_
43	high-level	high-level	JJ	JJ	_	44	amod	_	_
44	transcription	transcription	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	48	case	_	_
46	the	the	DT	DT	_	48	det	_	_
47	IL-4	il-4	NN	NN	_	48	compound	_	_
48	gene	gene	NN	NN	_	44	nmod	_	_
49	by	by	IN	IN	_	50	case	_	_
50	NFAT	nfat	NN	NN	_	44	nmod	_	_
51	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NFAT	nfat	NN	NN	_	1	nmod	_	_
4	could	could	MD	MD	_	9	aux	_	_
5	be	be	VB	VB	_	9	cop	_	_
6	therefore	therefore	RB	RB	_	9	advmod	_	_
7	a	a	DT	DT	_	9	det	_	_
8	critical	critical	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	polarization	polarization	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	eTh1	eth1	NN	NN	_	12	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	eTh2	eth2	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	p50	p50	NN	NN	_	5	compound	_	_
5	homodimer	homodimer	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	freshly	freshly	RB	RB	_	10	advmod	_	_
8	isolated	isolate	VBN	VBN	_	10	amod	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
11	decreases	decrease	VBZ	VBZ	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	in	in	FW	FW	_	11	nmod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	in	in	FW	FW	_	13	conj	_	_
17	vivo	vivo	FW	FW	_	16	dep	_	_
18	differentiation	differentiation	NN	NN	_	13	dep	_	_
19	:	:	:	:	_	11	punct	_	_
20	a	a	DT	DT	_	22	det	_	_
21	possible	possible	JJ	JJ	_	22	amod	_	_
22	mechanism	mechanism	NN	NN	_	11	dep	_	_
23	influencing	influence	VBG	VBG	_	22	acl	_	_
24	human	human	JJ	JJ	_	27	amod	_	_
25	immunodeficiency	immunodeficiency	NN	NN	_	27	compound	_	_
26	virus	virus	NN	NN	_	27	compound	_	_
27	replication	replication	NN	NN	_	23	dobj	_	_
28	in	in	IN	IN	_	29	case	_	_
29	monocytes	monocyte	NNS	NNS	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	mature	mature	JJ	JJ	_	32	amod	_	_
32	macrophages	macrophage	NNS	NNS	_	29	conj	_	_
33	.	.	.	.	_	11	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	9	nsubj	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HIV-1	hiv-1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	replicates	replicate	VBZ	VBZ	_	0	root	_	_
10	more	more	RBR	RBR	_	11	advmod	_	_
11	efficiently	efficiently	RB	RB	_	9	advmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	11	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	differentiated	differentiate	VBN	VBN	_	16	amod	_	_
16	macrophages	macrophage	NNS	NNS	_	11	nmod	_	_
17	than	than	IN	IN	_	21	case	_	_
18	in	in	IN	IN	_	21	case	_	_
19	freshly	freshly	RB	RB	_	21	advmod	_	_
20	isolated	isolate	VBN	VBN	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	8	mark	_	_
4	this	this	DT	DT	_	8	nsubjpass	_	_
5	may	may	MD	MD	_	8	aux	_	_
6	be	be	VB	VB	_	8	auxpass	_	_
7	partly	partly	RB	RB	_	8	advmod	_	_
8	explained	explain	VBN	VBN	_	2	ccomp	_	_
9	by	by	IN	IN	_	10	case	_	_
10	changes	change	NNS	NNS	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	monocyte	monocyte	NN	NN	_	17	compound	_	_
17	differentiation	differentiation	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	constitutive	constitutive	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
12	changed	change	VBD	VBD	_	2	ccomp	_	_
13	significantly	significantly	RB	RB	_	12	advmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	in	in	FW	FW	_	15	amod	_	_
17	vitro	vitro	FW	FW	_	16	dep	_	_
18	to	to	TO	TO	_	20	case	_	_
19	monocyte-derived	monocyte-derived	JJ	JJ	_	20	amod	_	_
20	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	MDMs	mdm	NNS	NNS	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	differentiation	differentiation	NN	NN	_	15	conj	_	_
26	in	in	FW	FW	_	25	amod	_	_
27	vivo	vivo	FW	FW	_	26	dep	_	_
28	to	to	TO	TO	_	30	case	_	_
29	alveolar	alveolar	JJ	JJ	_	30	amod	_	_
30	macrophages	macrophage	NNS	NNS	_	25	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	AMs	am	NNS	NNS	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	2	punct	_	_

1	Freshly	freshly	RB	RB	_	3	advmod	_	_
2	isolated	isolate	VBN	VBN	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	5	nsubj	_	_
4	constitutively	constitutively	RB	RB	_	5	advmod	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	high	high	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	transcriptionally	transcriptionally	RB	RB	_	12	advmod	_	_
10	inactive	inactive	JJ	JJ	_	12	amod	_	_
11	p50	p50	NN	NN	_	12	compound	_	_
12	homodimer	homodimer	NN	NN	_	7	nmod	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	decreased	decrease	VBD	VBD	_	7	acl:relcl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	time	time	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	culture	culture	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	favor	favor	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	dep	_	_
23	transcriptionally	transcriptionally	RB	RB	_	24	advmod	_	_
24	active	active	JJ	JJ	_	25	amod	_	_
25	p50/p65	p50/p65	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	p50/RelB	p50/relb	NN	NN	_	25	conj	_	_
28	heterodimers	heterodimer	NNS	NNS	_	25	dep	_	_
29	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	in	in	IN	IN	_	3	case	_	_
3	MDMs	mdm	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	AMs	am	NNS	NNS	_	7	nsubj	_	_
6	constitutively	constitutively	RB	RB	_	7	advmod	_	_
7	expressed	express	VBD	VBD	_	0	root	_	_
8	p50/p65	p50/p65	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	p50/RelB	p50/relb	NN	NN	_	8	conj	_	_
11	although	although	IN	IN	_	14	mark	_	_
12	at	at	IN	IN	_	14	case	_	_
13	lower	lower	JJR	JJR	_	14	amod	_	_
14	levels	level	NNS	NNS	_	7	advcl	_	_
15	.	.	.	.	_	7	punct	_	_

1	HIV	hiv	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	fresh	fresh	JJ	JJ	_	5	amod	_	_
5	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
6	failed	fail	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	induce	induce	VB	VB	_	6	xcomp	_	_
9	p50/p65	p50/p65	NN	NN	_	8	dobj	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	seen	see	VBN	VBN	_	6	advcl	_	_
12	in	in	IN	IN	_	13	case	_	_
13	MDMs	mdm	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	replacement	replacement	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	p50	p50	NN	NN	_	5	compound	_	_
5	homodimers	homodimer	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	transcriptionally	transcriptionally	RB	RB	_	8	advmod	_	_
8	active	active	JJ	JJ	_	9	amod	_	_
9	heterodimers	heterodimer	NNS	NNS	_	2	nmod	_	_
10	following	follow	VBG	VBG	_	11	case	_	_
11	time	time	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	culture	culture	NN	NN	_	11	nmod	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	partially	partially	RB	RB	_	16	advmod	_	_
16	explain	explain	VB	VB	_	0	root	_	_
17	the	the	DT	DT	_	19	det	_	_
18	progressive	progressive	JJ	JJ	_	19	amod	_	_
19	increase	increase	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	susceptibility	susceptibility	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	infection	infection	NN	NN	_	21	nmod	_	_
27	during	during	IN	IN	_	30	case	_	_
28	in	in	FW	FW	_	30	amod	_	_
29	vitro	vitro	FW	FW	_	28	dep	_	_
30	culture	culture	NN	NN	_	21	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	change	change	NN	NN	_	13	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	components	component	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	monocyte	monocyte	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	2	nmod	_	_
9	in	in	FW	FW	_	8	amod	_	_
10	vivo	vivo	FW	FW	_	9	dep	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	explain	explain	VB	VB	_	0	root	_	_
14	the	the	DT	DT	_	17	det	_	_
15	different	different	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	15	dep	_	_
17	activities	activity	NNS	NNS	_	13	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	these	these	DT	DT	_	21	det	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	populations	population	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	HIV-infected	hiv-infected	JJ	JJ	_	24	amod	_	_
24	individuals	individual	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nucleotide	nucleotide	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	regulate	regulate	VBP	VBP	_	4	acl:relcl	_	_
7	transcription	transcription	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	MCF13	mcf13	NN	NN	_	13	compound	_	_
11	murine	murine	JJ	JJ	_	13	amod	_	_
12	leukemia	leukemia	NN	NN	_	13	compound	_	_
13	virus	virus	NN	NN	_	7	nmod	_	_
14	long	long	JJ	JJ	_	16	amod	_	_
15	terminal	terminal	JJ	JJ	_	16	amod	_	_
16	repeat	repeat	NN	NN	_	13	dep	_	_
17	in	in	IN	IN	_	20	case	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	7	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	24	nsubj	_	_
3	downstream	downstream	JJ	JJ	_	2	advmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	enhancer	enhancer	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	DEN	den	NN	NN	_	3	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	long	long	JJ	JJ	_	14	amod	_	_
13	terminal	terminal	JJ	JJ	_	14	amod	_	_
14	repeat	repeat	NN	NN	_	3	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	mink	mink	NN	NN	_	19	nmod:npmod	_	_
18	cell	cell	NN	NN	_	19	nmod:npmod	_	_
19	focus-forming	focus-forming	JJ	JJ	_	22	amod	_	_
20	murine	murine	JJ	JJ	_	19	dep	_	_
21	leukemia	leukemia	NN	NN	_	22	compound	_	_
22	virus	virus	NN	NN	_	14	nmod	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	important	important	JJ	JJ	_	0	root	_	_
25	for	for	IN	IN	_	27	case	_	_
26	viral	viral	JJ	JJ	_	27	amod	_	_
27	pathogenicity	pathogenicity	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	24	punct	_	_

1	Another	another	DT	DT	_	3	det	_	_
2	important	important	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	DEN	den	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	control	control	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	determined	determine	VBN	VBN	_	8	conj	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	an	a	DT	DT	_	23	det	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	critical	critical	JJ	JJ	_	19	ccomp	_	_
26	for	for	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	activity	activity	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	1	nmod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	4	dep	_	_
7	in	in	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	T-lymphocytic	t-lymphocytic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	1	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	hypochlorous	hypochlorous	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Reactive	reactive	JJ	JJ	_	3	amod	_	_
2	oxygen	oxygen	NN	NN	_	3	compound	_	_
3	species	species	NNS	NNS	_	11	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	ROS	ro	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	such	such	JJ	JJ	_	10	case	_	_
8	as	as	IN	IN	_	7	mwe	_	_
9	hydrogen	hydrogen	NN	NN	_	10	compound	_	_
10	peroxide	peroxide	NN	NN	_	3	nmod	_	_
11	serve	serve	VBP	VBP	_	0	root	_	_
12	as	as	IN	IN	_	14	case	_	_
13	second	second	JJ	JJ	_	14	amod	_	_
14	messengers	messenger	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	17	nmod	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	21	dep	_	_
23	,	,	,	,	_	17	punct	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	hence	hence	RB	RB	_	28	advmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	dep	_	_
28	activation	activation	NN	NN	_	17	conj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	replication	replication	NN	NN	_	28	conj	_	_
31	of	of	IN	IN	_	35	case	_	_
32	human	human	JJ	JJ	_	35	amod	_	_
33	immunodeficiency	immunodeficiency	NN	NN	_	35	compound	_	_
34	virus	virus	NN	NN	_	35	compound	_	_
35	type	type	NN	NN	_	28	nmod	_	_
36	1	1	CD	CD	_	35	nummod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	HIV-1	hiv-1	NN	NN	_	35	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	in	in	IN	IN	_	42	case	_	_
41	human	human	JJ	JJ	_	42	amod	_	_
42	cells	cell	NNS	NNS	_	28	nmod	_	_
43	.	.	.	.	_	11	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	inflammatory	inflammatory	JJ	JJ	_	3	amod	_	_
3	reactions	reaction	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	many	many	JJ	JJ	_	7	amod	_	_
6	oxidative	oxidative	JJ	JJ	_	7	amod	_	_
7	species	species	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	produced	produce	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	one	one	CD	CD	_	16	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	which	which	WDT	WDT	_	11	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	hypochlorous	hypochlorous	JJ	JJ	_	16	amod	_	_
16	acid	acid	NN	NN	_	9	dep	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HOCl	hocl	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	16	punct	_	_
21	which	which	WDT	WDT	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	responsible	responsible	JJ	JJ	_	16	acl:relcl	_	_
24	for	for	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	microbicidal	microbicidal	JJ	JJ	_	27	amod	_	_
27	effects	effect	NNS	NNS	_	23	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	activated	activate	VBN	VBN	_	32	amod	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	polymorphonuclear	polymorphonuclear	JJ	JJ	_	32	amod	_	_
32	leukocytes	leukocyte	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	Treatment	treatment	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	T-lymphocytic	t-lymphocytic	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	micromolar	micromolar	JJ	JJ	_	9	amod	_	_
9	concentrations	concentration	NNS	NNS	_	1	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	HOCl	hocl	NN	NN	_	9	nmod	_	_
12	promoted	promote	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	appearance	appearance	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	14	nmod	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	17	dep	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	the	the	DT	DT	_	22	det	_	_
21	heterodimer	heterodimer	NN	NN	_	22	compound	_	_
22	p50/p65	p50/p65	NN	NN	_	17	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	nucleus	nucleus	NN	NN	_	14	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	,	,	,	,	_	14	punct	_	_
31	even	even	RB	RB	_	34	advmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	absence	absence	NN	NN	_	14	nmod	_	_
35	of	of	IN	IN	_	39	case	_	_
36	de	de	FW	FW	_	39	amod	_	_
37	novo	novo	FW	FW	_	36	dep	_	_
38	protein	protein	NN	NN	_	39	compound	_	_
39	synthesis	synthesis	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	12	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
7	inhibitory	inhibitory	JJ	JJ	_	8	amod	_	_
8	subunits	subunit	NNS	NNS	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IkappaB	ikappab	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	21	mark	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	IkappaB-alpha	ikappab-alpha	NN	NN	_	16	compound	_	_
16	proteolysis	proteolysis	NN	NN	_	21	nsubjpass	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	p105	p105	NN	NN	_	19	compound	_	_
19	processing	processing	NN	NN	_	16	conj	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	induced	induce	VBN	VBN	_	12	ccomp	_	_
22	by	by	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	treatment	treatment	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	very	very	RB	RB	_	5	advmod	_	_
5	effective	effective	JJ	JJ	_	0	root	_	_
6	when	when	WRB	WRB	_	9	advmod	_	_
7	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	subjected	subject	VBN	VBN	_	5	advcl	_	_
10	to	to	TO	TO	_	11	case	_	_
11	hyperthermia	hyperthermia	NN	NN	_	9	nmod	_	_
12	before	before	IN	IN	_	14	mark	_	_
13	being	be	VBG	VBG	_	14	auxpass	_	_
14	treated	treat	VBN	VBN	_	9	advcl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	HOCl	hocl	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Various	various	JJ	JJ	_	2	amod	_	_
2	antioxidants	antioxidant	NNS	NNS	_	15	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	such	such	JJ	JJ	_	7	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	pyrrolidine	pyrrolidine	NN	NN	_	7	compound	_	_
7	dithiocarbamate	dithiocarbamate	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	p-bromophenacyl-bromide	p-bromophenacyl-bromide	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	nordihydroguaiaretic	nordihydroguaiaretic	JJ	JJ	_	12	amod	_	_
12	acid	acid	NN	NN	_	7	conj	_	_
13	could	could	MD	MD	_	15	aux	_	_
14	strongly	strongly	RB	RB	_	15	advmod	_	_
15	reduce	reduce	VB	VB	_	0	root	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	translocation	translocation	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	15	punct	_	_
19	demonstrating	demonstrate	VBG	VBG	_	15	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	importance	importance	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	oxidative	oxidative	JJ	JJ	_	24	amod	_	_
24	species	species	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transduction	transduction	NN	NN	_	28	compound	_	_
28	mechanism	mechanism	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	Moreover	moreover	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	ACH-2	ach-2	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	10	nsubj	_	_
5	treated	treat	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	7	case	_	_
7	HOCl	hocl	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	H2O2	h2o2	NN	NN	_	7	conj	_	_
10	released	release	VBD	VBD	_	0	root	_	_
11	tumour	tumour	NN	NN	_	13	compound	_	_
12	necrosis	necrosis	NN	NN	_	13	compound	_	_
13	factor-alpha	factor-alpha	NN	NN	_	10	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	supernatants	supernatant	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	5	compound	_	_
5	release	release	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	HOCl	hocl	NN	NN	_	5	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	H2O2	h2o2	NN	NN	_	10	conj	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	fact	fact	NN	NN	_	14	nmod	_	_
18	that	that	IN	IN	_	29	mark	_	_
19	:	:	:	:	_	29	punct	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	1	1	LS	LS	_	29	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	the	the	DT	DT	_	25	det	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	appearance	appearance	NN	NN	_	29	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	25	nmod	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	promoted	promote	VBN	VBN	_	17	dep	_	_
30	in	in	IN	IN	_	32	case	_	_
31	untreated	untreated	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	;	;	:	:	_	29	punct	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	2	2	LS	LS	_	44	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	synergism	synergism	NN	NN	_	44	nsubjpass	_	_
39	between	between	IN	IN	_	40	case	_	_
40	TNF-alpha	tnf-alpha	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	HOCl	hocl	NN	NN	_	40	conj	_	_
43	was	be	VBD	VBD	_	44	auxpass	_	_
44	detected	detect	VBN	VBN	_	29	conj	_	_
45	.	.	.	.	_	14	punct	_	_

1	Collectively	collectively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	HOCl	hocl	NN	NN	_	10	nsubjpass	_	_
8	should	should	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	considered	consider	VBN	VBN	_	5	ccomp	_	_
11	as	as	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	oxidative	oxidative	JJ	JJ	_	14	amod	_	_
14	species	species	NNS	NNS	_	10	nmod	_	_
15	capable	capable	JJ	JJ	_	14	amod	_	_
16	of	of	IN	IN	_	17	mark	_	_
17	inducing	induce	VBG	VBG	_	15	advcl	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	T-lymphocytic	t-lymphocytic	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	line	line	NN	NN	_	17	nmod	_	_
24	through	through	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	transduction	transduction	NN	NN	_	27	compound	_	_
27	mechanism	mechanism	NN	NN	_	17	nmod	_	_
28	involving	involve	VBG	VBG	_	27	acl	_	_
29	ROS	ro	NNS	NNS	_	28	dobj	_	_
30	,	,	,	,	_	17	punct	_	_
31	and	and	CC	CC	_	17	cc	_	_
32	having	have	VBG	VBG	_	17	conj	_	_
33	a	a	DT	DT	_	35	det	_	_
34	long-distance	long-distance	JJ	JJ	_	35	amod	_	_
35	effect	effect	NN	NN	_	32	dobj	_	_
36	through	through	IN	IN	_	39	case	_	_
37	subsequent	subsequent	JJ	JJ	_	39	amod	_	_
38	TNF-alpha	tnf-alpha	NN	NN	_	39	compound	_	_
39	release	release	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
2	B-independent	b-independent	JJ	JJ	_	3	amod	_	_
3	suppression	suppression	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	HIV	hiv	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	ascorbic	ascorbic	JJ	JJ	_	9	amod	_	_
9	acid	acid	NN	NN	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Ascorbic	ascorbic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	11	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	ascorbate	ascorbate	NN	NN	_	2	dep	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	vitamin	vitamin	NN	NN	_	7	compound	_	_
7	C	c	NN	NN	_	4	conj	_	_
8	)	)	-RRB-	-RRB-	_	4	punct	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	shown	show	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	suppress	suppress	VB	VB	_	11	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	induction	induction	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HIV	hiv	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	latently	latently	RB	RB	_	23	advmod	_	_
20	infected	infected	JJ	JJ	_	23	amod	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	lymphocytic	lymphocytic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	15	nmod	_	_
24	following	follow	VBG	VBG	_	25	case	_	_
25	stimulation	stimulation	NN	NN	_	13	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	tumor	tumor	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PMA	pma	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	inflammatory	inflammatory	JJ	JJ	_	35	amod	_	_
35	cytokine	cytokine	NN	NN	_	29	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	TNF-alpha	tnf-alpha	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	assess	assess	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	7	mark	_	_
4	this	this	DT	DT	_	5	det	_	_
5	inhibition	inhibition	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
8	via	via	IN	IN	_	9	case	_	_
9	modulation	modulation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	cellular	cellular	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	appos	_	_
18	,	,	,	,	_	2	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	carried	carry	VBD	VBD	_	2	parataxis	_	_
21	out	out	RP	RP	_	20	compound:prt	_	_
22	gel	gel	NN	NN	_	24	compound	_	_
23	shift	shift	NN	NN	_	24	compound	_	_
24	analysis	analysis	NN	NN	_	20	dobj	_	_
25	on	on	IN	IN	_	27	case	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	extracts	extract	NNS	NNS	_	24	nmod	_	_
28	prepared	prepare	VBN	VBN	_	27	acl	_	_
29	under	under	IN	IN	_	31	case	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	conditions	condition	NNS	NNS	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	stimulation	stimulation	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	dep	_	_
37	presence	presence	NN	NN	_	28	nmod	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	absence	absence	NN	NN	_	37	conj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	ascorbate	ascorbate	NN	NN	_	37	nmod	_	_
42	,	,	,	,	_	41	punct	_	_
43	N-acetylcysteine	n-acetylcysteine	NN	NN	_	41	conj	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	NAC	nac	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	,	,	,	,	_	41	punct	_	_
48	or	or	CC	CC	_	41	cc	_	_
49	zidovudine	zidovudine	NN	NN	_	41	conj	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	AZT	azt	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	2	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	ACH-2	ach-2	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	NAC	nac	NN	NN	_	1	nmod	_	_
8	followed	follow	VBN	VBN	_	1	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	stimulation	stimulation	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	PMA	pma	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	or	or	CC	CC	_	12	cc	_	_
17	hydrogen	hydrogen	NN	NN	_	18	compound	_	_
18	peroxide	peroxide	NN	NN	_	12	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	H2O2	h2o2	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	resulted	result	VBD	VBD	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	strong	strong	JJ	JJ	_	25	amod	_	_
25	suppression	suppression	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	neither	neither	CC	CC	_	5	cc:preconj	_	_
5	ascorbate	ascorbate	NN	NN	_	8	nsubj	_	_
6	nor	nor	CC	CC	_	5	cc	_	_
7	AZT	azt	NN	NN	_	5	conj	_	_
8	affected	affect	VBD	VBD	_	0	root	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	under	under	IN	IN	_	16	case	_	_
13	all	all	DT	DT	_	16	det	_	_
14	three	three	CD	CD	_	16	nummod	_	_
15	induction	induction	NN	NN	_	16	compound	_	_
16	conditions	condition	NNS	NNS	_	8	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	ACH-2	ach-2	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	8	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Ascorbate	ascorbate	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	AZT	azt	NN	NN	_	1	conj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	on	on	IN	IN	_	11	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	following	follow	VBG	VBG	_	13	case	_	_
13	TNF-alpha-	tnf-alpha-	NN	NN	_	5	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	PMA-induced	pma-induced	JJ	JJ	_	13	conj	_	_
16	stimulation	stimulation	NN	NN	_	13	dep	_	_
17	of	of	IN	IN	_	20	case	_	_
18	U1	u1	NN	NN	_	20	compound	_	_
19	promonocytic	promonocytic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	15	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	inhibition	inhibition	NN	NN	_	7	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	ascorbate	ascorbate	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
16	via	via	IN	IN	_	19	case	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	inhibition	inhibition	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	unlike	unlike	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	15	nmod	_	_
23	seen	see	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	other	other	JJ	JJ	_	26	amod	_	_
26	antioxidants	antioxidant	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Egr-1/RelA	egr-1/rela	NN	NN	_	4	compound	_	_
4	synergy	synergy	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	distinguishing	distinguish	VBG	VBG	_	1	acl	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	from	from	IN	IN	_	16	case	_	_
11	tumor	tumor	NN	NN	_	16	compound	_	_
12	necrosis	necrosis	NN	NN	_	16	compound	_	_
13	factor-alpha-induced	factor-alpha-induced	JJ	JJ	_	16	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B1	b1	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	6	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	an	a	DT	DT	_	7	det	_	_
5	important	important	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	required	require	VBN	VBN	_	7	acl	_	_
9	for	for	IN	IN	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	immunological	immunological	JJ	JJ	_	16	amod	_	_
16	functions	function	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B1	b1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	nsubj	_	_
5	encodes	encode	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	105-kD	105-kd	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	5	dobj	_	_
9	that	that	WDT	WDT	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	the	the	DT	DT	_	12	det	_	_
12	precursor	precursor	NN	NN	_	8	acl:relcl	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	p50	p50	NN	NN	_	16	compound	_	_
16	component	component	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Previously	previously	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	we	we	PRP	PRP	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	others	other	NNS	NNS	_	3	conj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	nsubj	_	_
11	regulates	regulate	VBZ	VBZ	_	7	ccomp	_	_
12	the	the	DT	DT	_	15	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B1	b1	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	manuscript	manuscript	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	investigated	investigate	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	6	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	28	nmod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	28	nsubj	_	_
15	stimulated	stimulate	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	phorbol	phorbol	NN	NN	_	19	compound	_	_
18	12-myristate	12-myristate	NN	NN	_	19	compound	_	_
19	13-acetate	13-acetate	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMA	pma	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	phytohemagglutin	phytohemagglutin	NN	NN	_	19	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	PHA	pha	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	display	display	VBP	VBP	_	9	acl:relcl	_	_
29	significantly	significantly	RB	RB	_	30	advmod	_	_
30	higher	higher	JJR	JJR	_	31	amod	_	_
31	levels	level	NNS	NNS	_	28	dobj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B1	b1	NN	NN	_	35	compound	_	_
35	encoding	encoding	NN	NN	_	31	nmod	_	_
36	transcripts	transcript	NNS	NNS	_	35	dep	_	_
37	than	than	IN	IN	_	38	case	_	_
38	cells	cell	NNS	NNS	_	31	nmod	_	_
39	stimulated	stimulate	VBN	VBN	_	38	acl	_	_
40	with	with	IN	IN	_	43	case	_	_
41	tumor	tumor	NN	NN	_	43	compound	_	_
42	necrosis	necrosis	NN	NN	_	43	compound	_	_
43	factor-alpha	factor-alpha	NN	NN	_	39	nmod	_	_
44	,	,	,	,	_	28	punct	_	_
45	despite	despite	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	fact	fact	NN	NN	_	28	nmod	_	_
48	that	that	IN	IN	_	51	mark	_	_
49	both	both	DT	DT	_	50	det	_	_
50	stimuli	stimulus	NNS	NNS	_	51	nsubj	_	_
51	activate	activate	VBP	VBP	_	47	ccomp	_	_
52	NF-kappa	nf-kappa	NN	NN	_	53	compound	_	_
53	B	b	NN	NN	_	51	dobj	_	_
54	.	.	.	.	_	6	punct	_	_

1	Characterization	characterization	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B1	b1	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	1	nmod	_	_
7	identified	identify	VBD	VBD	_	0	root	_	_
8	an	a	DT	DT	_	10	det	_	_
9	Egr-1	egr-1	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	7	dobj	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	10	acl:relcl	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	essential	essential	JJ	JJ	_	13	xcomp	_	_
17	for	for	IN	IN	_	21	case	_	_
18	both	both	CC	CC	_	21	dep	_	_
19	the	the	DT	DT	_	21	det	_	_
20	PMA/PHA-mediated	pma/pha-mediated	JJ	JJ	_	21	amod	_	_
21	induction	induction	NN	NN	_	16	nmod	_	_
22	as	as	RB	RB	_	21	cc	_	_
23	well	well	RB	RB	_	22	mwe	_	_
24	as	as	IN	IN	_	22	mwe	_	_
25	the	the	DT	DT	_	27	det	_	_
26	synergistic	synergistic	JJ	JJ	_	27	amod	_	_
27	activation	activation	NN	NN	_	21	conj	_	_
28	observed	observe	VBN	VBN	_	27	acl	_	_
29	after	after	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	expression	expression	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	RelA	rela	NN	NN	_	35	compound	_	_
35	subunit	subunit	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	35	nmod	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	Egr-1	egr-1	NN	NN	_	35	conj	_	_
41	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	Egr-1	egr-1	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	12	case	_	_
8	endogenous	endogenous	JJ	JJ	_	12	amod	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B1	b1	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	since	since	IN	IN	_	24	mark	_	_
15	PMA/PHA-stimulated	pma/pha-stimulated	JJ	JJ	_	18	amod	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	24	nsubjpass	_	_
19	expressing	express	VBG	VBG	_	18	acl	_	_
20	antisense	antisense	JJ	JJ	_	22	amod	_	_
21	Egr-1	egr-1	NN	NN	_	22	compound	_	_
22	RNA	rna	NN	NN	_	19	dobj	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	inhibited	inhibit	VBN	VBN	_	6	advcl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
27	ability	ability	NN	NN	_	24	nmod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	upregulate	upregulate	VB	VB	_	27	acl	_	_
30	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
31	B1	b1	NN	NN	_	32	compound	_	_
32	transcription	transcription	NN	NN	_	29	dobj	_	_
33	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	synergy	synergy	NN	NN	_	17	nsubj	_	_
7	mediated	mediate	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	Egr-1	egr-1	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	conj	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	have	have	VBP	VBP	_	3	ccomp	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	ramifications	ramification	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	development	development	NN	NN	_	19	nmod	_	_
24	by	by	IN	IN	_	25	mark	_	_
25	upregulating	upregulate	VBG	VBG	_	17	advcl	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B1	b1	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	25	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	synthesis	synthesis	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	immunogenicity	immunogenicity	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	varicella-zoster	varicella-zoster	NN	NN	_	9	compound	_	_
7	virus	virus	NN	NN	_	9	compound	_	_
8	glycoprotein	glycoprotein	NN	NN	_	9	compound	_	_
9	E	e	NN	NN	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	immediate-early	immediate-early	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	9	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IE62	ie62	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	expressed	express	VBN	VBN	_	9	acl	_	_
17	in	in	IN	IN	_	21	case	_	_
18	recombinant	recombinant	JJ	JJ	_	21	amod	_	_
19	herpes	herpes	NN	NN	_	21	compound	_	_
20	simplex	simplex	NN	NN	_	21	compound	_	_
21	virus-1	virus-1	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	evaluate	evaluate	VB	VB	_	30	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	conditions	condition	NNS	NNS	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	optimal	optimal	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	immunogenicity	immunogenicity	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	18	case	_	_
13	varicella-zoster	varicella-zoster	JJ	JJ	_	18	amod	_	_
14	virus	virus	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	VZV	vzv	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	proteins	protein	NNS	NNS	_	9	nmod	_	_
19	in	in	IN	IN	_	27	case	_	_
20	a	a	DT	DT	_	27	det	_	_
21	herpes	herpes	NN	NN	_	23	compound	_	_
22	simplex	simplex	NN	NN	_	23	compound	_	_
23	virus-1	virus-1	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	HSV-1	hsv-1	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	vector	vector	NN	NN	_	9	nmod	_	_
28	,	,	,	,	_	30	punct	_	_
29	we	we	PRP	PRP	_	30	nsubj	_	_
30	selected	select	VBD	VBD	_	0	root	_	_
31	the	the	DT	DT	_	34	det	_	_
32	VZV	vzv	NN	NN	_	34	compound	_	_
33	glycoprotein	glycoprotein	NN	NN	_	34	compound	_	_
34	E	e	NN	NN	_	30	dobj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	gE	ge	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	,	,	,	,	_	34	punct	_	_
39	encoded	encode	VBN	VBN	_	34	acl	_	_
40	by	by	IN	IN	_	41	case	_	_
41	ORF	orf	NN	NN	_	39	nmod	_	_
42	68	68	CD	CD	_	41	nummod	_	_
43	and	and	CC	CC	_	41	cc	_	_
44	the	the	DT	DT	_	46	det	_	_
45	VZV	vzv	NN	NN	_	46	compound	_	_
46	product	product	NN	NN	_	41	conj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	ORF	orf	NN	NN	_	46	nmod	_	_
49	62	62	CD	CD	_	48	nummod	_	_
50	,	,	,	,	_	46	punct	_	_
51	an	a	DT	DT	_	55	det	_	_
52	immediate-early	immediate-early	JJ	JJ	_	55	amod	_	_
53	major	major	JJ	JJ	_	55	amod	_	_
54	tegument	tegument	NN	NN	_	55	compound	_	_
55	protein	protein	NN	NN	_	46	appos	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	IE62	ie62	NN	NN	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	30	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	HSV/VZV	hsv/vzv	NN	NN	_	3	compound	_	_
3	recombinants	recombinant	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	generated	generate	VBN	VBN	_	0	root	_	_
6	:	:	:	:	_	5	punct	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1	1	LS	LS	_	21	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	VZV	vzv	NN	NN	_	14	compound	_	_
11	gE	ge	NN	NN	_	14	compound	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	coding	coding	NN	NN	_	14	compound	_	_
14	sequences	sequence	NNS	NNS	_	21	nsubjpass	_	_
15	along	along	IN	IN	_	19	case	_	_
16	with	with	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	region	region	NN	NN	_	14	nmod	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	inserted	insert	VBN	VBN	_	5	parataxis	_	_
22	into	into	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	thymidine	thymidine	NN	NN	_	29	compound	_	_
25	kinase	kinase	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	TK	tk	NN	NN	_	29	compound	_	_
28	)	)	-RRB-	-RRB-	_	29	punct	_	_
29	gene	gene	NN	NN	_	21	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	HSV-1	hsv-1	NN	NN	_	33	compound	_	_
32	strain	strain	NN	NN	_	33	compound	_	_
33	KOS	kos	NN	NN	_	29	nmod	_	_
34	;	;	:	:	_	21	punct	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	2	2	LS	LS	_	47	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	VZV	vzv	NN	NN	_	39	compound	_	_
39	gE	ge	NN	NN	_	47	nsubjpass	_	_
40	expressed	express	VBN	VBN	_	39	acl	_	_
41	from	from	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	HSV-1	hsv-1	NN	NN	_	45	compound	_	_
44	ICP4	icp4	NN	NN	_	45	compound	_	_
45	promoter	promoter	NN	NN	_	40	nmod	_	_
46	was	be	VBD	VBD	_	47	auxpass	_	_
47	inserted	insert	VBN	VBN	_	21	conj	_	_
48	into	into	IN	IN	_	55	case	_	_
49	the	the	DT	DT	_	55	det	_	_
50	glycoprotein	glycoprotein	NN	NN	_	55	compound	_	_
51	C	c	NN	NN	_	55	compound	_	_
52	(	(	-LRB-	-LRB-	_	55	punct	_	_
53	gC	gc	NN	NN	_	55	compound	_	_
54	)	)	-RRB-	-RRB-	_	55	punct	_	_
55	gene	gene	NN	NN	_	47	nmod	_	_
56	of	of	IN	IN	_	59	case	_	_
57	HSV-1	hsv-1	NN	NN	_	59	compound	_	_
58	strain	strain	NN	NN	_	59	compound	_	_
59	F	f	NN	NN	_	55	nmod	_	_
60	;	;	:	:	_	21	punct	_	_
61	and	and	CC	CC	_	21	cc	_	_
62	(	(	-LRB-	-LRB-	_	63	punct	_	_
63	3	3	LS	LS	_	79	dep	_	_
64	)	)	-RRB-	-RRB-	_	63	punct	_	_
65	VZV	vzv	NN	NN	_	69	compound	_	_
66	IE62	ie62	NN	NN	_	69	compound	_	_
67	protein	protein	NN	NN	_	69	compound	_	_
68	coding	coding	NN	NN	_	69	compound	_	_
69	sequences	sequence	NNS	NNS	_	79	nsubjpass	_	_
70	under	under	IN	IN	_	72	case	_	_
71	the	the	DT	DT	_	72	det	_	_
72	control	control	NN	NN	_	69	nmod	_	_
73	of	of	IN	IN	_	77	case	_	_
74	the	the	DT	DT	_	77	det	_	_
75	HSV-1	hsv-1	NN	NN	_	77	compound	_	_
76	ICP4	icp4	NN	NN	_	77	compound	_	_
77	promoter	promoter	NN	NN	_	72	nmod	_	_
78	were	be	VBD	VBD	_	79	auxpass	_	_
79	inserted	insert	VBN	VBN	_	21	conj	_	_
80	into	into	IN	IN	_	83	case	_	_
81	the	the	DT	DT	_	83	det	_	_
82	gC	gc	NN	NN	_	83	compound	_	_
83	gene	gene	NN	NN	_	79	nmod	_	_
84	of	of	IN	IN	_	87	case	_	_
85	HSV-1	hsv-1	NN	NN	_	87	compound	_	_
86	strain	strain	NN	NN	_	87	compound	_	_
87	F	f	NN	NN	_	83	nmod	_	_
88	.	.	.	.	_	5	punct	_	_

1	Immunoblot	immunoblot	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	immunoperoxidase	immunoperoxidase	NN	NN	_	5	compound	_	_
5	staining	staining	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	infected	infected	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	monolayers	monolayer	NNS	NNS	_	5	nmod	_	_
10	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
11	vector	vector	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	VZV	vzv	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Following	follow	VBG	VBG	_	3	case	_	_
2	intracranial	intracranial	JJ	JJ	_	3	amod	_	_
3	inoculation	inoculation	NN	NN	_	19	nmod	_	_
4	in	in	IN	IN	_	5	case	_	_
5	mice	mouse	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	19	punct	_	_
7	both	both	CC	CC	_	9	cc:preconj	_	_
8	VZV	vzv	NN	NN	_	9	compound	_	_
9	gE-HSV	ge-hsv	NN	NN	_	19	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TK	tk	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	VZV	vzv	NN	NN	_	15	compound	_	_
15	IE62-HSV	ie62-hsv	NN	NN	_	9	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	gC	gc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	induced	induce	VBD	VBD	_	0	root	_	_
20	an	a	DT	DT	_	22	det	_	_
21	IgG	igg	NN	NN	_	22	compound	_	_
22	response	response	NN	NN	_	19	dobj	_	_
23	against	against	IN	IN	_	25	case	_	_
24	VZV	vzv	NN	NN	_	25	compound	_	_
25	gE	ge	NN	NN	_	19	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	VZV	vzv	NN	NN	_	28	compound	_	_
28	IE62	ie62	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	19	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	tested	test	VBN	VBN	_	29	advcl	_	_
3	in	in	IN	IN	_	5	case	_	_
4	cytotoxicity	cytotoxicity	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	2	nmod	_	_
6	using	use	VBG	VBG	_	5	acl	_	_
7	T-lymphocytes	t-lymphocyte	NNS	NNS	_	6	dobj	_	_
8	from	from	IN	IN	_	12	case	_	_
9	VZV	vzv	NN	NN	_	12	compound	_	_
10	immune	immune	JJ	JJ	_	12	amod	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	donors	donor	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	29	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	range	range	NN	NN	_	29	nsubj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	precursor	precursor	NN	NN	_	18	compound	_	_
18	frequencies	frequency	NNS	NNS	_	15	nmod	_	_
19	for	for	IN	IN	_	20	case	_	_
20	T-lymphocytes	t-lymphocyte	NNS	NNS	_	18	nmod	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	recognized	recognize	VBD	VBD	_	20	acl:relcl	_	_
23	VZV	vzv	NN	NN	_	24	compound	_	_
24	gE	ge	NN	NN	_	22	dobj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	VZV	vzv	NN	NN	_	27	compound	_	_
27	IE62	ie62	NN	NN	_	24	conj	_	_
28	was	be	VBD	VBD	_	29	cop	_	_
29	similar	similar	JJ	JJ	_	0	root	_	_
30	whether	whether	IN	IN	_	34	mark	_	_
31	these	these	DT	DT	_	32	det	_	_
32	proteins	protein	NNS	NNS	_	34	nsubjpass	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	expressed	express	VBN	VBN	_	29	ccomp	_	_
35	by	by	IN	IN	_	36	case	_	_
36	HSV-1	hsv-1	NN	NN	_	34	nmod	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	a	a	DT	DT	_	40	det	_	_
39	vaccinia	vaccinia	NN	NN	_	40	compound	_	_
40	vector	vector	NN	NN	_	36	conj	_	_
41	.	.	.	.	_	29	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	HSV-1	hsv-1	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	competent	competent	JJ	JJ	_	9	amod	_	_
9	vector	vector	NN	NN	_	3	ccomp	_	_
10	for	for	IN	IN	_	11	case	_	_
11	expression	expression	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	VZV	vzv	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	support	support	VBP	VBP	_	3	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	feasibility	feasibility	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	mark	_	_
21	engineering	engineer	VBG	VBG	_	19	acl	_	_
22	a	a	DT	DT	_	24	det	_	_
23	combined	combined	JJ	JJ	_	24	amod	_	_
24	vaccine	vaccine	NN	NN	_	21	dobj	_	_
25	for	for	IN	IN	_	29	case	_	_
26	these	these	DT	DT	_	29	det	_	_
27	closely	closely	RB	RB	_	28	advmod	_	_
28	related	related	JJ	JJ	_	29	amod	_	_
29	alpha-herpesviruses	alpha-herpesvirus	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Correlation	correlation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	lymphocytic	lymphocytic	JJ	JJ	_	5	amod	_	_
5	infiltration	infiltration	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	tumor	tumor	NN	NN	_	8	compound	_	_
8	tissue	tissue	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	hormonal	hormonal	JJ	JJ	_	2	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	metabolic	metabolic	JJ	JJ	_	11	conj	_	_
14	state	state	NN	NN	_	11	dep	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	11	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	breast	breast	NN	NN	_	19	compound	_	_
19	cancer	cancer	NN	NN	_	16	nmod	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	2	compound	_	_
2	infiltration	infiltration	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	tumor	tumor	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	studied	study	VBN	VBN	_	0	root	_	_
7	vis-a-vis	vis-a-vis	FW	FW	_	10	dep	_	_
8	hormone	hormone	NN	NN	_	10	compound	_	_
9	metabolic	metabolic	JJ	JJ	_	10	amod	_	_
10	status	status	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	tumor	tumor	NN	NN	_	15	compound	_	_
13	tissue	tissue	NN	NN	_	15	compound	_	_
14	hormone	hormone	NN	NN	_	15	compound	_	_
15	sensitivity	sensitivity	NN	NN	_	10	conj	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	tobacco	tobacco	NN	NN	_	18	compound	_	_
18	smoking	smoking	NN	NN	_	10	conj	_	_
19	,	,	,	,	_	6	punct	_	_
20	in	in	IN	IN	_	24	case	_	_
21	113	113	CD	CD	_	24	nummod	_	_
22	breast	breast	NN	NN	_	24	compound	_	_
23	cancer	cancer	NN	NN	_	24	compound	_	_
24	patients	patient	NNS	NNS	_	6	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	aged	aged	JJ	JJ	_	24	amod	_	_
27	25-77	25-77	CD	CD	_	26	dep	_	_
28	.	.	.	.	_	6	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	average	average	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	correlation	correlation	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	established	establish	VBN	VBN	_	0	root	_	_
9	between	between	IN	IN	_	10	case	_	_
10	degree	degree	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	lymphocyte	lymphocyte	NN	NN	_	13	compound	_	_
13	infiltration	infiltration	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	breast	breast	NN	NN	_	16	compound	_	_
16	tumor	tumor	NN	NN	_	10	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	age	age	NN	NN	_	10	conj	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	menopause	menopause	NN	NN	_	21	compound	_	_
21	onset	onset	NN	NN	_	10	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	smoking	smoking	NN	NN	_	4	compound	_	_
3	menopausal	menopausal	JJ	JJ	_	4	amod	_	_
4	patients	patient	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	infiltration	infiltration	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	higher	higher	JJR	JJR	_	9	xcomp	_	_
13	than	than	IN	IN	_	15	case	_	_
14	in	in	IN	IN	_	15	case	_	_
15	non-smokers	non-smoker	NNS	NNS	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	p	p	NN	NN	_	15	dep	_	_
18	&lt;	&lt;	JJR	JJR	_	17	amod	_	_
19	0.05	0.05	CD	CD	_	18	dep	_	_
20	)	)	-RRB-	-RRB-	_	17	punct	_	_
21	.	.	.	.	_	9	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	correlation	correlation	NN	NN	_	2	nsubj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	rate	rate	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	infiltration	infiltration	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	level	level	NN	NN	_	8	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	progesterone	progesterone	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	tumor	tumor	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	subgroups	subgroup	NNS	NNS	_	3	nsubj	_	_
3	displayed	display	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	direct	direct	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	3	dobj	_	_
7	between	between	IN	IN	_	8	case	_	_
8	infiltration	infiltration	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	sex-binding	sex-binding	JJ	JJ	_	11	amod	_	_
11	globulin	globulin	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	11	punct	_	_
13	cholesterol	cholesterol	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	luteinizing	luteinizing	JJ	JJ	_	16	amod	_	_
16	hormone	hormone	NN	NN	_	11	appos	_	_
17	in	in	IN	IN	_	18	case	_	_
18	blood	blood	NN	NN	_	11	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	lean	lean	JJ	JJ	_	23	amod	_	_
22	body	body	NN	NN	_	23	compound	_	_
23	mass	mass	NN	NN	_	8	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	matched	match	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	inverse	inverse	JJ	JJ	_	7	amod	_	_
7	correlation	correlation	NN	NN	_	3	nmod	_	_
8	between	between	IN	IN	_	10	case	_	_
9	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
10	infiltration	infiltration	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	blood-thyroid	blood-thyroid	JJ	JJ	_	14	amod	_	_
13	hormone	hormone	NN	NN	_	14	compound	_	_
14	concentration	concentration	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	14	punct	_	_
16	urine	urine	NN	NN	_	17	compound	_	_
17	catecholamines	catecholamine	NNS	NNS	_	14	conj	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	free	free	JJ	JJ	_	21	amod	_	_
20	cortisol	cortisol	NN	NN	_	21	compound	_	_
21	excretion	excretion	NN	NN	_	14	conj	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	fat/lean	fat/lean	JJ	JJ	_	26	amod	_	_
24	body	body	NN	NN	_	26	compound	_	_
25	mass	mass	NN	NN	_	26	compound	_	_
26	ratio	ratio	NN	NN	_	14	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Considering	consider	VBG	VBG	_	2	case	_	_
2	the	the	DT	DT	_	22	nmod	_	_
3	abovesaid	abovesaid	VBN	VBN	_	2	amod	_	_
4	as	as	RB	RB	_	2	cc	_	_
5	well	well	RB	RB	_	4	mwe	_	_
6	as	as	IN	IN	_	4	mwe	_	_
7	the	the	DT	DT	_	9	det	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	ability	ability	NN	NN	_	2	conj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	perform	perform	VB	VB	_	9	acl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	dual	dual	JJ	JJ	_	14	amod	_	_
14	function	function	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	immunocytes	immunocyte	NNS	NNS	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	hormonocytes	hormonocyte	NNS	NNS	_	16	conj	_	_
19	,	,	,	,	_	22	punct	_	_
20	it	it	PRP	PRP	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	suggested	suggest	VBN	VBN	_	0	root	_	_
23	that	that	IN	IN	_	28	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	results	result	NNS	NNS	_	28	nsubjpass	_	_
26	may	may	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	used	use	VBN	VBN	_	22	ccomp	_	_
29	in	in	IN	IN	_	32	case	_	_
30	both	both	CC	CC	_	32	cc:preconj	_	_
31	the	the	DT	DT	_	32	det	_	_
32	study	study	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	lymphocyte	lymphocyte	NN	NN	_	35	compound	_	_
35	infiltration	infiltration	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	research	research	NN	NN	_	32	conj	_	_
38	in	in	IN	IN	_	39	case	_	_
39	means	means	NNS	NNS	_	37	nmod	_	_
40	of	of	IN	IN	_	42	case	_	_
41	its	its	PRP$	PRP$	_	42	nmod:poss	_	_
42	control	control	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	22	punct	_	_

1	Thymocytes	thymocyte	NNS	NNS	_	2	nsubj	_	_
2	control	control	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CD4	cd4	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	2	dobj	_	_
6	differently	differently	RB	RB	_	2	advmod	_	_
7	from	from	IN	IN	_	10	case	_	_
8	mature	mature	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analyzed	analyze	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activity	activity	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	enhancer	enhancer	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	promoter	promoter	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	silencer	silencer	NN	NN	_	7	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	CD4	cd4	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	7	nmod	_	_
19	during	during	IN	IN	_	22	case	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	development	development	NN	NN	_	4	nmod	_	_
23	using	use	VBG	VBG	_	2	xcomp	_	_
24	transgenic	transgenic	JJ	JJ	_	25	amod	_	_
25	mice	mouse	NNS	NNS	_	23	dobj	_	_
26	.	.	.	.	_	2	punct	_	_

1	Immunofluorescence	immunofluorescence	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	18	nsubj	_	_
3	on	on	IN	IN	_	5	case	_	_
4	thymic	thymic	JJ	JJ	_	5	amod	_	_
5	populations	population	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	mice	mouse	NNS	NNS	_	5	nmod	_	_
8	carrying	carry	VBG	VBG	_	7	acl	_	_
9	transgenes	transgene	NNS	NNS	_	8	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	various	various	JJ	JJ	_	12	amod	_	_
12	combinations	combination	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	these	these	DT	DT	_	17	det	_	_
15	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	elements	element	NNS	NNS	_	12	nmod	_	_
18	revealed	reveal	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	thymocytes	thymocyte	NNS	NNS	_	21	nsubj	_	_
21	control	control	VBP	VBP	_	18	ccomp	_	_
22	the	the	DT	DT	_	24	det	_	_
23	CD4	cd4	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	different	different	JJ	JJ	_	28	amod	_	_
28	manner	manner	NN	NN	_	21	nmod	_	_
29	than	than	IN	IN	_	33	case	_	_
30	mature	mature	JJ	JJ	_	33	amod	_	_
31	peripheral	peripheral	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	5'-positive	5'-positive	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	unit	unit	NN	NN	_	17	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	consisting	consist	VBG	VBG	_	4	acl	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	5'	5'	JJ	JJ	_	13	amod	_	_
13	enhancer	enhancer	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	4	punct	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	already	already	RB	RB	_	17	advmod	_	_
17	active	active	JJ	JJ	_	0	root	_	_
18	at	at	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	det	_	_
20	CD4-CD8-double-negative	cd4-cd8-double-negative	JJ	JJ	_	24	amod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	DN	dn	JJ	JJ	_	20	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	stage	stage	NN	NN	_	17	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	development	development	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	activity	activity	NN	NN	_	5	nsubj	_	_
5	becomes	become	VBZ	VBZ	_	0	root	_	_
6	lower	lower	JJR	JJR	_	5	xcomp	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	double-positive	double-positive	JJ	JJ	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	fraction	fraction	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	CD4+	cd4+	JJ	JJ	_	18	amod	_	_
16	CD8int/-	cd8int/-	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	population	population	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	indicating	indicate	VBG	VBG	_	5	xcomp	_	_
21	that	that	IN	IN	_	41	mark	_	_
22	an	a	DT	DT	_	24	det	_	_
23	additional	additional	JJ	JJ	_	24	amod	_	_
24	enhancer	enhancer	NN	NN	_	41	nsubjpass	_	_
25	,	,	,	,	_	24	punct	_	_
26	located	located	JJ	JJ	_	24	amod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	either	either	CC	CC	_	30	cc:preconj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	first	first	JJ	JJ	_	26	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	third	third	JJ	JJ	_	30	conj	_	_
34	intron	intron	NN	NN	_	30	dep	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	CD4	cd4	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	30	nmod	_	_
39	,	,	,	,	_	24	punct	_	_
40	is	be	VBZ	VBZ	_	41	auxpass	_	_
41	required	require	VBN	VBN	_	20	ccomp	_	_
42	for	for	IN	IN	_	45	case	_	_
43	CD4	cd4	NN	NN	_	44	compound	_	_
44	gene	gene	NN	NN	_	45	compound	_	_
45	expression	expression	NN	NN	_	41	nmod	_	_
46	in	in	IN	IN	_	48	case	_	_
47	this	this	DT	DT	_	48	det	_	_
48	population	population	NN	NN	_	45	nmod	_	_
49	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	other	other	JJ	JJ	_	5	amod	_	_
3	studied	study	VBN	VBN	_	5	amod	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	element	element	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	the	the	DT	DT	_	10	det	_	_
8	minimal	minimal	JJ	JJ	_	10	amod	_	_
9	CD4	cd4	NN	NN	_	10	compound	_	_
10	silencer	silencer	NN	NN	_	0	root	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	inhibits	inhibit	VBZ	VBZ	_	10	acl:relcl	_	_
13	CD4	cd4	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
18	CD8	cd8	NN	NN	_	20	compound	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	silencer	silencer	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	inactive	inactive	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	most	most	RBS	RBS	_	10	advmod	_	_
8	immature	immature	JJ	JJ	_	10	amod	_	_
9	DN	dn	JJ	JJ	_	10	amod	_	_
10	thymocytes	thymocyte	NNS	NNS	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	probably	probably	RB	RB	_	14	advmod	_	_
14	use	use	VBP	VBP	_	10	acl:relcl	_	_
15	a	a	DT	DT	_	18	det	_	_
16	distinct	distinct	JJ	JJ	_	18	amod	_	_
17	silencer	silencer	NN	NN	_	18	compound	_	_
18	mechanism	mechanism	NN	NN	_	14	dobj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	down-regulate	down-regulate	VB	VB	_	14	xcomp	_	_
21	CD4	cd4	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CD4	cd4	NN	NN	_	5	compound	_	_
5	silencer	silencer	NN	NN	_	8	nsubj	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	active	active	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
11	CD8int/-	cd8int/-	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	thymus	thymus	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	implying	imply	VBG	VBG	_	8	xcomp	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	an	a	DT	DT	_	20	det	_	_
20	anti-silencer	anti-silencer	NN	NN	_	23	nsubjpass	_	_
21	may	may	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	required	require	VBN	VBN	_	17	ccomp	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	resume	resume	VB	VB	_	23	xcomp	_	_
26	CD4	cd4	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	this	this	DT	DT	_	31	det	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	population	population	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Altogether	altogether	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CD4	cd4	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	regulated	regulate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	several	several	JJ	JJ	_	10	amod	_	_
10	positive	positive	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	negative	negative	JJ	JJ	_	10	conj	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	10	dep	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	come	come	VBP	VBP	_	10	acl:relcl	_	_
17	into	into	IN	IN	_	18	case	_	_
18	play	play	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	developmentally	developmentally	RB	RB	_	22	advmod	_	_
22	coordinated	coordinate	VBN	VBN	_	23	amod	_	_
23	manner	manner	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Heat-shock	heat-shock	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cadmium	cadmium	NN	NN	_	4	compound	_	_
4	chloride	chloride	NN	NN	_	1	conj	_	_
5	increase	increase	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	8	dep	_	_
7	vimentin	vimentin	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	protein	protein	NN	NN	_	8	conj	_	_
11	levels	level	NNS	NNS	_	8	dep	_	_
12	in	in	IN	IN	_	16	case	_	_
13	U-937	u-937	NN	NN	_	16	compound	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	promonocytic	promonocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Heat-shock	heat-shock	NN	NN	_	24	nsubj	_	_
2	for	for	IN	IN	_	4	case	_	_
3	2	2	CD	CD	_	4	nummod	_	_
4	hours	hour	NNS	NNS	_	1	nmod	_	_
5	at	at	IN	IN	_	8	case	_	_
6	42	42	CD	CD	_	8	nummod	_	_
7	degrees	degree	NNS	NNS	_	8	compound	_	_
8	C	c	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	or	or	CC	CC	_	1	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	administration	administration	NN	NN	_	1	conj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	3	3	CD	CD	_	15	nummod	_	_
15	hours	hour	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	100	100	CD	CD	_	20	dep	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	150	150	CD	CD	_	17	conj	_	_
20	microM	microm	NN	NN	_	22	dep	_	_
21	cadmium	cadmium	NN	NN	_	22	compound	_	_
22	chloride	chloride	NN	NN	_	12	nmod	_	_
23	,	,	,	,	_	1	punct	_	_
24	inhibited	inhibit	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	28	det	_	_
26	subsequent	subsequent	JJ	JJ	_	28	amod	_	_
27	proliferation	proliferation	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	24	dobj	_	_
29	,	,	,	,	_	24	punct	_	_
30	induced	induce	VBD	VBD	_	24	conj	_	_
31	the	the	DT	DT	_	32	det	_	_
32	expression	expression	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	functional	functional	JJ	JJ	_	36	amod	_	_
35	differentiation	differentiation	NN	NN	_	36	compound	_	_
36	markers	marker	NNS	NNS	_	32	nmod	_	_
37	,	,	,	,	_	24	punct	_	_
38	and	and	CC	CC	_	24	cc	_	_
39	caused	cause	VBD	VBD	_	24	conj	_	_
40	an	a	DT	DT	_	41	det	_	_
41	increase	increase	NN	NN	_	39	dobj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	amount	amount	NN	NN	_	41	nmod	_	_
45	of	of	IN	IN	_	49	case	_	_
46	the	the	DT	DT	_	49	det	_	_
47	stress-responsive	stress-responsive	JJ	JJ	_	49	amod	_	_
48	HSP70	hsp70	NN	NN	_	49	compound	_	_
49	protein	protein	NN	NN	_	44	nmod	_	_
50	in	in	IN	IN	_	54	case	_	_
51	U-937	u-937	NN	NN	_	54	compound	_	_
52	human	human	JJ	JJ	_	54	amod	_	_
53	promonocytic	promonocytic	JJ	JJ	_	54	amod	_	_
54	cells	cell	NNS	NNS	_	49	nmod	_	_
55	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	heat	heat	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cadmium	cadmium	NN	NN	_	5	conj	_	_
8	produced	produce	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	amount	amount	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	intermediate	intermediate	JJ	JJ	_	18	amod	_	_
17	filament	filament	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	13	nmod	_	_
19	vimentin	vimentin	NN	NN	_	18	dep	_	_
20	,	,	,	,	_	8	punct	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	determined	determine	VBN	VBN	_	8	advcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	immunoblot	immunoblot	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	immunofluorescence	immunofluorescence	NN	NN	_	24	conj	_	_
27	assays	assay	NNS	NNS	_	24	dep	_	_
28	.	.	.	.	_	8	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	amounts	amount	NNS	NNS	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	actin	actin	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	beta-tubulin	beta-tubulin	NN	NN	_	7	conj	_	_
10	were	be	VBD	VBD	_	13	auxpass	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	altered	alter	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	amount	amount	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	vimentin	vimentin	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	increased	increase	VBN	VBN	_	0	root	_	_
9	during	during	IN	IN	_	10	case	_	_
10	recovery	recovery	NN	NN	_	8	nmod	_	_
11	from	from	IN	IN	_	12	case	_	_
12	stress	stress	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	indicating	indicate	VBG	VBG	_	8	advcl	_	_
15	that	that	IN	IN	_	21	mark	_	_
16	vimentin	vimentin	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	21	nsubjpass	_	_
18	was	be	VBD	VBD	_	21	auxpass	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	exclusively	exclusively	RB	RB	_	21	advmod	_	_
21	regulated	regulate	VBN	VBN	_	14	ccomp	_	_
22	at	at	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	level	level	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	cadmium	cadmium	NN	NN	_	3	nsubj	_	_
3	caused	cause	VBD	VBD	_	20	advcl	_	_
4	an	a	DT	DT	_	8	det	_	_
5	early	early	JJ	JJ	_	8	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	transient	transient	JJ	JJ	_	5	dep	_	_
8	stimulation	stimulation	NN	NN	_	3	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-jun	c-jun	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	c-fos	c-fos	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	conj	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	8	conj	_	_
18	,	,	,	,	_	20	punct	_	_
19	heat-shock	heat-shock	NN	NN	_	20	nsubj	_	_
20	failed	fail	VBD	VBD	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	alter	alter	VB	VB	_	20	xcomp	_	_
23	both	both	CC	CC	_	25	cc:preconj	_	_
24	protooncogene	protooncogene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	transcription	transcription	NN	NN	_	29	compound	_	_
28	factor	factor	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	20	punct	_	_
31	indicating	indicate	VBG	VBG	_	20	xcomp	_	_
32	that	that	IN	IN	_	40	mark	_	_
33	the	the	DT	DT	_	36	det	_	_
34	stress-induced	stress-induced	JJ	JJ	_	36	amod	_	_
35	vimentin	vimentin	NN	NN	_	36	compound	_	_
36	increase	increase	NN	NN	_	40	nsubj	_	_
37	was	be	VBD	VBD	_	40	cop	_	_
38	not	not	RB	RB	_	40	neg	_	_
39	the	the	DT	DT	_	40	det	_	_
40	result	result	NN	NN	_	31	ccomp	_	_
41	of	of	IN	IN	_	44	case	_	_
42	AP-1-mediated	ap-1-mediated	JJ	JJ	_	44	amod	_	_
43	transcriptional	transcriptional	JJ	JJ	_	44	amod	_	_
44	activation	activation	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	20	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	rate	rate	NN	NN	_	19	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	decay	decay	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	vimentin	vimentin	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	10	nmod	_	_
14	upon	upon	IN	IN	_	17	case	_	_
15	actinomycin	actinomycin	NN	NN	_	17	compound	_	_
16	D	d	NN	NN	_	17	compound	_	_
17	administration	administration	NN	NN	_	10	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	decreased	decrease	VBN	VBN	_	5	ccomp	_	_
20	in	in	IN	IN	_	21	case	_	_
21	heat-	heat-	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	cadmium-pretreated	cadmium-pretreated	JJ	JJ	_	21	conj	_	_
24	cells	cell	NNS	NNS	_	21	dep	_	_
25	in	in	IN	IN	_	26	case	_	_
26	comparison	comparison	NN	NN	_	19	nmod	_	_
27	to	to	TO	TO	_	29	case	_	_
28	untreated	untreated	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	stress	stress	NN	NN	_	6	compound	_	_
6	treatments	treatment	NNS	NNS	_	7	nsubj	_	_
7	cause	cause	VBP	VBP	_	3	ccomp	_	_
8	an	a	DT	DT	_	9	det	_	_
9	increase	increase	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	vimentin	vimentin	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	promonocytic	promonocytic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	which	which	WDT	WDT	_	20	nsubjpass	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	explained	explain	VBN	VBN	_	3	ccomp	_	_
21	at	at	IN	IN	_	24	advmod	_	_
22	least	least	JJS	JJS	_	21	mwe	_	_
23	in	in	IN	IN	_	24	case	_	_
24	part	part	NN	NN	_	20	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	transcript	transcript	NN	NN	_	27	compound	_	_
27	stabilization	stabilization	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Jak1	jak1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	6	mark	_	_
6	mediating	mediate	VBG	VBG	_	4	advcl	_	_
7	interleukin-4-induced	interleukin-4-induced	JJ	JJ	_	9	amod	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	insulin	insulin	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	substrate	substrate	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Stat6	stat6	NN	NN	_	13	conj	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	molecules	molecule	NNS	NNS	_	15	dep	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	Jak1	jak1	NN	NN	_	14	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	Jak2	jak2	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	Jak3	jak3	NN	NN	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	Fes	fes	NN	NN	_	2	conj	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	kinases	kinase	NNS	NNS	_	2	dep	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	undergo	undergo	VB	VB	_	14	xcomp	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	16	nmod	_	_
21	to	to	TO	TO	_	27	case	_	_
22	interleukin	interleukin	NN	NN	_	24	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	IL	il	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	-4	-4	CD	CD	_	24	nummod	_	_
27	stimulation	stimulation	NN	NN	_	20	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	different	different	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	systems	system	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	clear	clear	JJ	JJ	_	0	root	_	_
7	which	which	WDT	WDT	_	16	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	if	if	IN	IN	_	10	mark	_	_
10	any	any	DT	DT	_	7	dep	_	_
11	,	,	,	,	_	7	punct	_	_
12	of	of	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	kinases	kinase	NNS	NNS	_	7	nmod	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	responsible	responsible	JJ	JJ	_	6	ccomp	_	_
17	for	for	IN	IN	_	18	mark	_	_
18	initiating	initiate	VBG	VBG	_	16	advcl	_	_
19	IL-4-induced	il-4-induced	JJ	JJ	_	21	amod	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
24	substrates	substrate	NNS	NNS	_	21	nmod	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	18	advmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	utilized	utilize	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	14	det	_	_
10	mutant	mutant	JJ	JJ	_	14	amod	_	_
11	Jak1-deficient	jak1-deficient	JJ	JJ	_	14	amod	_	_
12	HeLa	hela	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	8	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	E1C3	e1c3	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
20	parental	parental	JJ	JJ	_	22	amod	_	_
21	Jak1-expressing	jak1-expressing	JJ	JJ	_	22	amod	_	_
22	counterpart	counterpart	NN	NN	_	14	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	1D4	1d4	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	8	punct	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	analyze	analyze	VB	VB	_	8	xcomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	role	role	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	Jak1	jak1	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	33	mark	_	_
33	mediating	mediate	VBG	VBG	_	29	acl	_	_
34	IL-4-induced	il-4-induced	JJ	JJ	_	37	amod	_	_
35	tyrosine	tyrosine	NN	NN	_	37	compound	_	_
36	phosphorylation	phosphorylation	NN	NN	_	37	compound	_	_
37	events	event	NNS	NNS	_	33	dobj	_	_
38	.	.	.	.	_	8	punct	_	_

1	IL-4	il-4	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	4	nsubj	_	_
3	rapidly	rapidly	RB	RB	_	4	advmod	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	insulin	insulin	NN	NN	_	12	compound	_	_
9	receptor	receptor	NN	NN	_	12	compound	_	_
10	substrate	substrate	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IRS	irs	NN	NN	_	6	nmod	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-1	-1	CD	CD	_	12	nummod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	IRS-2	irs-2	NN	NN	_	12	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	1D4	1d4	NN	NN	_	4	nmod	_	_
19	but	but	CC	CC	_	18	cc	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	in	in	IN	IN	_	23	case	_	_
22	E1C3	e1c3	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	IL-4-mediated	il-4-mediated	JJ	JJ	_	3	amod	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Stat6	stat6	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	pronounced	pronounce	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	1D4	1d4	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	while	while	IN	IN	_	18	mark	_	_
13	no	no	DT	DT	_	16	neg	_	_
14	IL-4-induced	il-4-induced	JJ	JJ	_	16	amod	_	_
15	Stat6	stat6	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	detected	detect	VBN	VBN	_	7	advcl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	E1C3	e1c3	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	IL-4	il-4	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	Stat6	stat6	NN	NN	_	7	compound	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	from	from	IN	IN	_	9	case	_	_
9	lysates	lysate	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	1D4	1d4	NN	NN	_	9	nmod	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	11	cc	_	_
14	E1C3	e1c3	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	conj	_	_
16	utilizing	utilize	VBG	VBG	_	3	xcomp	_	_
17	a	a	DT	DT	_	25	det	_	_
18	radiolabeled	radiolabele	VBN	VBN	_	25	amod	_	_
19	immunoglobulin	immunoglobulin	NN	NN	_	25	compound	_	_
20	heavy	heavy	JJ	JJ	_	25	amod	_	_
21	chain	chain	NN	NN	_	25	compound	_	_
22	germline	germline	NN	NN	_	25	compound	_	_
23	epsilon	epsilon	NN	NN	_	25	compound	_	_
24	promotor	promotor	NN	NN	_	25	compound	_	_
25	sequence	sequence	NN	NN	_	16	dobj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	Iepsilon	iepsilon	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	in	in	IN	IN	_	34	case	_	_
30	an	a	DT	DT	_	34	det	_	_
31	electrophoretic	electrophoretic	JJ	JJ	_	34	amod	_	_
32	mobility	mobility	NN	NN	_	34	compound	_	_
33	shift	shift	NN	NN	_	34	compound	_	_
34	assay	assay	NN	NN	_	16	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Reconstitution	reconstitution	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Jak1	jak1	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	E1C3	e1c3	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	restored	restore	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	ability	ability	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-4	il-4	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	induce	induce	VB	VB	_	10	acl	_	_
15	IRS	irs	NN	NN	_	14	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Stat6	stat6	NN	NN	_	15	conj	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphorylation	phosphorylation	NN	NN	_	15	dep	_	_
20	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	Jak1	jak1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	required	require	VBN	VBN	_	4	ccomp	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	mediating	mediate	VBG	VBG	_	9	advcl	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	activation	activation	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	crucial	crucial	JJ	JJ	_	18	amod	_	_
18	molecules	molecule	NNS	NNS	_	15	nmod	_	_
19	involved	involve	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	23	case	_	_
21	IL-4	il-4	NN	NN	_	23	compound	_	_
22	signal	signal	NN	NN	_	23	compound	_	_
23	transduction	transduction	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Immune	immune	JJ	JJ	_	2	amod	_	_
2	hyperactivation	hyperactivation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HIV-1-infected	hiv-1-infected	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	mediated	mediate	VBN	VBN	_	2	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	Tat	tat	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD28	cd28	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	9	conj	_	_
14	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	compound	_	_
3	virus-type	virus-type	NN	NN	_	8	compound	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HIV-1	hiv-1	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	infection	infection	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	characterized	characterize	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	chronic	chronic	JJ	JJ	_	14	amod	_	_
14	state	state	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	hyperactivation	hyperactivation	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Infection	infection	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	HIV-1	hiv-1	NN	NN	_	1	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	1	advmod	_	_
11	resulted	result	VBD	VBD	_	0	root	_	_
12	in	in	IN	IN	_	18	case	_	_
13	increased	increase	VBN	VBN	_	18	amod	_	_
14	interleukin-2	interleukin-2	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-2	il-2	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	secretion	secretion	NN	NN	_	11	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	20	nmod	_	_
25	via	via	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	dep	_	_
27	CD3	cd3	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD28	cd28	NN	NN	_	27	conj	_	_
30	receptors	receptor	NNS	NNS	_	27	dep	_	_
31	.	.	.	.	_	11	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	transactivator	transactivator	NN	NN	_	1	nmod	_	_
6	Tat	tat	NN	NN	_	5	dep	_	_
7	recapitulated	recapitulate	VBD	VBD	_	0	root	_	_
8	this	this	DT	DT	_	9	det	_	_
9	phenotype	phenotype	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	7	conj	_	_
13	with	with	IN	IN	_	16	case	_	_
14	increased	increase	VBN	VBN	_	16	amod	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	secretion	secretion	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	response	response	NN	NN	_	16	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	costimulation	costimulation	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	CD3	cd3	NN	NN	_	20	nmod	_	_
23	plus	plus	CC	CC	_	22	cc	_	_
24	CD28	cd28	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	IL-2	il-2	NN	NN	_	2	compound	_	_
2	superinduction	superinduction	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	Tat	tat	NN	NN	_	2	nmod	_	_
5	occurred	occur	VBD	VBD	_	0	root	_	_
6	at	at	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	level	level	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	5	conj	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CD28-responsive	cd28-responsive	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IL-2	il-2	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	and	and	CC	CC	_	5	cc	_	_
23	was	be	VBD	VBD	_	25	cop	_	_
24	exclusively	exclusively	RB	RB	_	25	advmod	_	_
25	dependent	dependent	JJ	JJ	_	5	conj	_	_
26	on	on	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	29	29	CD	CD	_	30	nummod	_	_
29	amino	amino	NN	NN	_	30	compound	_	_
30	acids	acid	NNS	NNS	_	25	nmod	_	_
31	encoded	encode	VBN	VBN	_	30	acl	_	_
32	by	by	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	second	second	JJ	JJ	_	37	amod	_	_
35	exon	exon	NN	NN	_	37	compound	_	_
36	of	of	IN	IN	_	37	amod	_	_
37	Tat	tat	NN	NN	_	31	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	c-Rel	c-rel	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	target	target	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	pentoxifylline-mediated	pentoxifylline-mediated	JJ	JJ	_	7	amod	_	_
7	inhibition	inhibition	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	possible	possible	JJ	JJ	_	4	amod	_	_
3	clinical	clinical	JJ	JJ	_	2	dep	_	_
4	use	use	NN	NN	_	25	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	methyl	methyl	NN	NN	_	8	compound	_	_
8	xanthine	xanthine	NN	NN	_	4	nmod	_	_
9	derivative	derivative	JJ	JJ	_	8	amod	_	_
10	,	,	,	,	_	8	punct	_	_
11	pentoxifylline	pentoxifylline	NN	NN	_	8	appos	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PF	pf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	4	punct	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	treatment	treatment	NN	NN	_	4	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell-dependent	cell-dependent	JJ	JJ	_	22	amod	_	_
22	diseases	disease	NNS	NNS	_	18	nmod	_	_
23	is	be	VBZ	VBZ	_	25	aux	_	_
24	being	be	VBG	VBG	_	25	auxpass	_	_
25	noted	note	VBN	VBN	_	0	root	_	_
26	with	with	IN	IN	_	28	case	_	_
27	increasing	increase	VBG	VBG	_	28	amod	_	_
28	interest	interest	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	studied	study	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	consequences	consequence	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	PF	pf	NN	NN	_	12	compound	_	_
12	treatment	treatment	NN	NN	_	9	nmod	_	_
13	during	during	IN	IN	_	15	case	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	12	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	10	amod	_	_
9	c-Rel	c-rel	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	blocked	block	VBN	VBN	_	2	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	PF	pf	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	whereas	whereas	IN	IN	_	27	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	induction	induction	NN	NN	_	27	nsubjpass	_	_
19	of	of	IN	IN	_	23	case	_	_
20	other	other	JJ	JJ	_	23	amod	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
22	family	family	NN	NN	_	23	compound	_	_
23	members	member	NNS	NNS	_	18	nmod	_	_
24	was	be	VBD	VBD	_	27	auxpass	_	_
25	not	not	RB	RB	_	27	neg	_	_
26	significantly	significantly	RB	RB	_	27	advmod	_	_
27	affected	affect	VBN	VBN	_	12	advcl	_	_
28	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	induction	induction	NN	NN	_	19	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-AT	nf-at	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	has	have	VBZ	VBZ	_	3	acl:relcl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	same	same	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	requirements	requirement	NNS	NNS	_	8	dobj	_	_
13	as	as	IN	IN	_	15	case	_	_
14	c-Rel	c-rel	NN	NN	_	15	compound	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	inhibited	inhibit	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	21	case	_	_
21	PF	pf	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	19	punct	_	_

1	Among	among	IN	IN	_	2	case	_	_
2	genes	gene	NNS	NNS	_	14	nmod	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	respond	respond	VBP	VBP	_	2	acl:relcl	_	_
5	to	to	TO	TO	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	14	punct	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	suppressed	suppress	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PF	pf	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	14	punct	_	_
18	whereas	whereas	IN	IN	_	28	mark	_	_
19	IL-2R	il-2r	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	alpha	alpha	NN	NN	_	24	compound	_	_
22	)	)	-RRB-	-RRB-	_	24	punct	_	_
23	chain	chain	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	induction	induction	NN	NN	_	28	nsubjpass	_	_
26	was	be	VBD	VBD	_	28	auxpass	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	affected	affect	VBN	VBN	_	14	advcl	_	_
29	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	implicated	implicate	VBD	VBD	_	0	root	_	_
4	c-Rel	c-rel	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	3	nmod	_	_
9	factor	factor	IN	IN	_	8	amod	_	_
10	,	,	,	,	_	8	punct	_	_
11	for	for	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	16	nmod	_	_
13	experimental	experimental	JJ	JJ	_	14	amod	_	_
14	support	support	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	obtained	obtain	VBN	VBN	_	8	acl:relcl	_	_
17	from	from	IN	IN	_	20	case	_	_
18	transient	transient	JJ	JJ	_	20	amod	_	_
19	transfection	transfection	NN	NN	_	20	compound	_	_
20	experiments	experiment	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	with	with	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	observation	observation	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	14	punct	_	_
10	c-Rel	c-rel	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	14	nsubjpass	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PF	pf	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	greater	greater	JJR	JJR	_	3	amod	_	_
3	selectivity	selectivity	NN	NN	_	19	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	PF	pf	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	compared	compare	VBN	VBN	_	9	case	_	_
8	with	with	IN	IN	_	9	case	_	_
9	FK506	fk506	NN	NN	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	at	at	IN	IN	_	14	case	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	molecular	molecular	JJ	JJ	_	3	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cellular	cellular	JJ	JJ	_	14	conj	_	_
17	levels	level	NNS	NNS	_	14	dep	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	prove	prove	VB	VB	_	0	root	_	_
20	advantageous	advantageous	JJ	JJ	_	19	xcomp	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	manipulating	manipulate	VBG	VBG	_	20	advcl	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	responses	response	NNS	NNS	_	22	dobj	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vivo	vivo	FW	FW	_	25	advmod	_	_
28	.	.	.	.	_	19	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell-specific	cell-specific	JJ	JJ	_	4	amod	_	_
4	enhancer	enhancer	NN	NN	_	10	nsubjpass	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	interleukin-3	interleukin-3	NN	NN	_	8	compound	_	_
8	locus	locus	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	activated	activate	VBN	VBN	_	0	root	_	_
11	cooperatively	cooperatively	RB	RB	_	10	advmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Oct	oct	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NFAT	nfat	NN	NN	_	13	conj	_	_
16	elements	element	NNS	NNS	_	13	dep	_	_
17	within	within	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	DNase	dnase	NN	NN	_	21	compound	_	_
20	I-hypersensitive	i-hypersensitive	JJ	JJ	_	21	amod	_	_
21	site	site	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	Interleukin-3	interleukin-3	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-3	il-3	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	cytokine	cytokine	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	7	acl:relcl	_	_
11	primarily	primarily	RB	RB	_	15	advmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	8	det	_	_
5	inducible	inducible	JJ	JJ	_	8	amod	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell-specific	cell-specific	JJ	JJ	_	8	amod	_	_
8	enhancer	enhancer	NN	NN	_	3	dobj	_	_
9	14	14	CD	CD	_	10	nummod	_	_
10	kb	kb	NN	NN	_	11	nmod:npmod	_	_
11	upstream	upstream	RB	RB	_	8	advmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-3	il-3	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	8	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	responded	respond	VBD	VBD	_	8	acl:relcl	_	_
18	to	to	TO	TO	_	19	case	_	_
19	activation	activation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	25	compound	_	_
24	signaling	signaling	NN	NN	_	25	compound	_	_
25	pathways	pathway	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-3	il-3	NN	NN	_	3	compound	_	_
3	enhancer	enhancer	NN	NN	_	4	nsubj	_	_
4	spanned	span	VBD	VBD	_	0	root	_	_
5	an	a	DT	DT	_	11	det	_	_
6	inducible	inducible	JJ	JJ	_	11	amod	_	_
7	cyclosporin	cyclosporin	NN	NN	_	11	compound	_	_
8	A-sensitive	a-sensitive	JJ	JJ	_	11	amod	_	_
9	DNase	dnase	NN	NN	_	11	compound	_	_
10	I-hypersensitive	i-hypersensitive	JJ	JJ	_	11	amod	_	_
11	site	site	NN	NN	_	4	dobj	_	_
12	found	find	VBN	VBN	_	11	acl	_	_
13	only	only	RB	RB	_	16	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Four	four	CD	CD	_	3	nummod	_	_
2	NFAT-like	nfat-like	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	4	nsubj	_	_
4	exist	exist	VBP	VBP	_	0	root	_	_
5	within	within	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	enhancer	enhancer	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	two	two	CD	CD	_	6	nummod	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	active	active	JJ	JJ	_	6	amod	_	_
5	NFAT-like	nfat-like	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	located	located	JJ	JJ	_	0	root	_	_
9	at	at	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	center	center	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	DNase	dnase	NN	NN	_	16	compound	_	_
15	I-hypersensitive	i-hypersensitive	JJ	JJ	_	16	amod	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	these	these	DT	DT	_	5	det	_	_
4	NFAT-like	nfat-like	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	1	nmod	_	_
6	encompassed	encompass	VBD	VBD	_	0	root	_	_
7	overlapping	overlap	VBG	VBG	_	8	amod	_	_
8	Oct-	oct-	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	NFATp/c-binding	nfatp/c-binding	JJ	JJ	_	8	conj	_	_
11	sites	site	NNS	NNS	_	8	dep	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	functioned	function	VBD	VBD	_	8	acl:relcl	_	_
15	in	in	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	highly	highly	RB	RB	_	18	advmod	_	_
18	synergistic	synergistic	JJ	JJ	_	19	amod	_	_
19	manner	manner	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	T	t	NN	NN	_	8	compound	_	_
6	cell-	cell-	NN	NN	_	8	compound	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	15	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-3	il-3	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	partly	partly	RB	RB	_	15	advmod	_	_
15	controlled	control	VBN	VBN	_	2	ccomp	_	_
16	through	through	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	enhancer	enhancer	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	cooperation	cooperation	NN	NN	_	15	nmod	_	_
21	between	between	IN	IN	_	22	case	_	_
22	Oct	oct	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NFAT	nfat	NN	NN	_	22	conj	_	_
25	family	family	NN	NN	_	26	compound	_	_
26	proteins	protein	NNS	NNS	_	22	dep	_	_
27	.	.	.	.	_	2	punct	_	_

1	TRAMP	tramp	NN	NN	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	apoptosis-mediating	apoptosis-mediating	JJ	JJ	_	6	amod	_	_
6	receptor	receptor	NN	NN	_	1	appos	_	_
7	with	with	IN	IN	_	9	case	_	_
8	sequence	sequence	NN	NN	_	9	compound	_	_
9	homology	homology	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	tumor	tumor	NN	NN	_	14	compound	_	_
12	necrosis	necrosis	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	9	nmod	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	Fas	fas	NN	NN	_	14	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	Apo-1/CD95	apo-1/cd95	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	novel	novel	JJ	JJ	_	3	amod	_	_
3	member	member	NN	NN	_	20	nsubjpass	_	_
4	of	of	IN	IN	_	13	case	_	_
5	the	the	DT	DT	_	13	det	_	_
6	tumor	tumor	NN	NN	_	13	compound	_	_
7	necrosis	necrosis	NN	NN	_	13	compound	_	_
8	factor	factor	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	TNF	tnf	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	3	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	designated	designate	VBN	VBN	_	3	acl	_	_
16	TRAMP	tramp	NN	NN	_	15	xcomp	_	_
17	,	,	,	,	_	3	punct	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	identified	identify	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	structural	structural	JJ	JJ	_	3	amod	_	_
3	organization	organization	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	393	393	CD	CD	_	11	nummod	_	_
7	amino	amino	NN	NN	_	11	compound	_	_
8	acid	acid	NN	NN	_	11	compound	_	_
9	long	long	JJ	JJ	_	11	amod	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	TRAMP	tramp	NN	NN	_	3	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	most	most	RBS	RBS	_	14	advmod	_	_
14	homologous	homologous	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	TNF	tnf	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	14	nmod	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	.	.	.	.	_	14	punct	_	_

1	TRAMP	tramp	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	abundantly	abundantly	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	on	on	IN	IN	_	6	case	_	_
6	thymocytes	thymocyte	NNS	NNS	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	6	conj	_	_
9	.	.	.	.	_	4	punct	_	_

1	Its	its	PRP$	PRP$	_	3	nmod:poss	_	_
2	extracellular	extracellular	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	composed	compose	VBN	VBN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	four	four	CD	CD	_	9	nummod	_	_
8	cysteine-rich	cysteine-rich	JJ	JJ	_	9	amod	_	_
9	domains	domain	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	15	nsubj	_	_
15	contains	contain	VBZ	VBZ	_	5	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	death	death	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	15	dobj	_	_
19	known	know	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	signal	signal	NN	NN	_	22	compound	_	_
22	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TRAMP	tramp	NN	NN	_	1	nmod	_	_
4	leads	lead	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	two	two	CD	CD	_	8	nummod	_	_
7	major	major	JJ	JJ	_	8	amod	_	_
8	responses	response	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	apoptosis	apoptosis	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	TRAMP-induced	tramp-induced	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	death	death	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	an	a	DT	DT	_	8	det	_	_
8	inhibitor	inhibitor	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	ICE-like	ice-like	JJ	JJ	_	11	amod	_	_
11	proteases	protease	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	but	but	CC	CC	_	8	cc	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	by	by	IN	IN	_	16	case	_	_
16	Bcl-2	bcl-2	NN	NN	_	8	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	TRAMP	tramp	NN	NN	_	7	nsubj	_	_
5	does	do	VBZ	VBZ	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	appear	appear	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	interact	interact	VB	VB	_	7	xcomp	_	_
10	with	with	IN	IN	_	11	case	_	_
11	any	any	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	known	known	JJ	JJ	_	16	amod	_	_
15	apoptosis-inducing	apoptosis-inducing	JJ	JJ	_	16	amod	_	_
16	ligands	ligand	NNS	NNS	_	11	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	TNF	tnf	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	tissue	tissue	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	AP-1	ap-1	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B/Rel	b/rel	NN	NN	_	3	conj	_	_
7	,	,	,	,	_	3	punct	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	Sp1	sp1	NN	NN	_	3	conj	_	_
10	proteins	protein	NNS	NNS	_	3	dep	_	_
11	in	in	IN	IN	_	12	case	_	_
12	uninduced	uninduced	JJ	JJ	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	12	conj	_	_
15	expression	expression	NN	NN	_	12	dep	_	_
16	.	.	.	.	_	1	punct	_	_

1	Tissue	tissue	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	TF	tf	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	expression	expression	NN	NN	_	13	nsubj	_	_
7	by	by	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
11	during	during	IN	IN	_	12	case	_	_
12	sepsis	sepsis	NN	NN	_	6	nmod	_	_
13	initiates	initiate	VBZ	VBZ	_	0	root	_	_
14	intravascular	intravascular	JJ	JJ	_	15	amod	_	_
15	thrombosis	thrombosis	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	13	punct	_	_

1	Bacterial	bacterial	JJ	JJ	_	2	amod	_	_
2	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	LPS	lps	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	rapidly	rapidly	RB	RB	_	7	advmod	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	TF	tf	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	TF	tf	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	sites	site	NNS	NNS	_	5	dobj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	AP-1	ap-1	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	c-Rel/p65	c-rel/p65	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	Egr-1	egr-1	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	Sp1	sp1	NN	NN	_	12	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
2	B/Rel	b/rel	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	6	nsubjpass	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	physically	physically	RB	RB	_	9	advmod	_	_
9	interact	interact	VB	VB	_	6	xcomp	_	_
10	with	with	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	AP-1	ap-1	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Sp1	sp1	NN	NN	_	12	conj	_	_
15	proteins	protein	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	these	these	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	uninduced	uninduced	JJ	JJ	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	LPS-induced	lps-induced	JJ	JJ	_	14	conj	_	_
17	TF	tf	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	14	dep	_	_
20	in	in	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
23	THP-1	thp-1	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Deletional	deletional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	five	five	CD	CD	_	7	nummod	_	_
6	Sp1	sp1	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	8	nsubj	_	_
8	mediated	mediate	VBD	VBD	_	3	ccomp	_	_
9	basal	basal	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	uninduced	uninduced	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	AP-1	ap-1	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	5	nsubj	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	7	compound	_	_
7	heterodimers	heterodimer	NNS	NNS	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	unstimulated	unstimulated	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	LPS-stimulated	lps-stimulated	JJ	JJ	_	10	conj	_	_
13	cells	cell	NNS	NNS	_	10	dep	_	_
14	.	.	.	.	_	5	punct	_	_

1	Maximal	maximal	JJ	JJ	_	3	amod	_	_
2	LPS	lps	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	TF	tf	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	required	require	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	two	two	CD	CD	_	12	nummod	_	_
11	AP-1	ap-1	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	8	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	17	det	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	12	conj	_	_
18	within	within	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	LPS	lps	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Disruption	disruption	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	conserved	conserve	VBN	VBN	_	5	amod	_	_
5	spacing	spacing	NN	NN	_	1	nmod	_	_
6	between	between	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	proximal	proximal	JJ	JJ	_	10	amod	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	15	det	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	10	conj	_	_
16	abolished	abolish	VBD	VBD	_	0	root	_	_
17	LPS	lps	NN	NN	_	18	compound	_	_
18	induction	induction	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	16	punct	_	_

1	Replacement	replacement	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	AP-1	ap-1	NN	NN	_	6	compound	_	_
6	sites	site	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	intrinsically	intrinsically	RB	RB	_	9	advmod	_	_
9	bent	bent	JJ	JJ	_	10	amod	_	_
10	DNA	dna	NN	NN	_	1	nmod	_	_
11	partially	partially	RB	RB	_	12	advmod	_	_
12	restored	restore	VBD	VBD	_	0	root	_	_
13	LPS	lps	NN	NN	_	14	compound	_	_
14	induction	induction	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	12	punct	_	_
16	suggesting	suggest	VBG	VBG	_	12	advcl	_	_
17	an	a	DT	DT	_	20	det	_	_
18	additional	additional	JJ	JJ	_	20	amod	_	_
19	structural	structural	JJ	JJ	_	18	dep	_	_
20	role	role	NN	NN	_	16	dobj	_	_
21	for	for	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	AP-1	ap-1	NN	NN	_	24	compound	_	_
24	sites	site	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	Synergistic	synergistic	JJ	JJ	_	2	amod	_	_
2	transactivation	transactivation	NN	NN	_	27	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	LPS	lps	NN	NN	_	7	compound	_	_
6	response	response	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	Drosophila	drosophila	FW	FW	_	11	compound	_	_
10	Schneider	schneider	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	coexpression	coexpression	NN	NN	_	2	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	c-Fos	c-fos	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	c-Jun	c-jun	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	c-Rel	c-rel	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	p65	p65	NN	NN	_	15	conj	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	c-Jun	c-jun	NN	NN	_	22	conj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	p65	p65	NN	NN	_	24	conj	_	_
27	required	require	VBD	VBD	_	0	root	_	_
28	the	the	DT	DT	_	30	det	_	_
29	transactivation	transactivation	NN	NN	_	30	compound	_	_
30	domains	domain	NNS	NNS	_	27	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	c-Jun	c-jun	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	p65	p65	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	27	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	11	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	c-Rel/p65	c-rel/p65	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	Sp1	sp1	NN	NN	_	5	conj	_	_
11	regulate	regulate	VBP	VBP	_	3	ccomp	_	_
12	TF	tf	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	AML1a	aml1a	NN	NN	_	5	nsubj	_	_
2	but	but	CC	CC	_	3	cc	_	_
3	not	not	RB	RB	_	1	cc	_	_
4	AML1b	aml1b	NN	NN	_	1	conj	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
7	differentiation	differentiation	NN	NN	_	5	dobj	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	butyrate	butyrate	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	enhances	enhance	VBZ	VBZ	_	5	conj	_	_
14	the	the	DT	DT	_	16	det	_	_
15	megakaryocytic	megakaryocytic	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	K562	k562	NN	NN	_	20	compound	_	_
19	leukemia	leukemia	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	AML1	aml1	NN	NN	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	play	play	VB	VB	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	growth	growth	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	differentiation	differentiation	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	along	along	IN	IN	_	13	case	_	_
13	erythroid	erythroid	JJ	JJ	_	11	nmod	_	_
14	and/or	and/or	CC	CC	_	13	cc	_	_
15	megakaryocytic	megakaryocytic	JJ	JJ	_	13	conj	_	_
16	lineages	lineage	NNS	NNS	_	13	dep	_	_
17	,	,	,	,	_	3	punct	_	_
18	because	because	IN	IN	_	27	mark	_	_
19	a	a	DT	DT	_	21	det	_	_
20	significant	significant	JJ	JJ	_	21	amod	_	_
21	level	level	NN	NN	_	27	nsubjpass	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	AML1	aml1	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	21	nmod	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	expressed	express	VBN	VBN	_	3	advcl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	overexpressed	overexpress	VBD	VBD	_	0	root	_	_
3	AML1a	aml1a	NN	NN	_	2	dobj	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	without	without	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription-activating	transcription-activating	JJ	JJ	_	8	amod	_	_
8	domain	domain	NN	NN	_	3	nmod	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	AML1b	aml1b	NN	NN	_	3	conj	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	domain	domain	NN	NN	_	11	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	proteins	protein	NNS	NNS	_	3	dep	_	_
18	in	in	IN	IN	_	21	case	_	_
19	K562	k562	NN	NN	_	21	compound	_	_
20	leukemia	leukemia	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	2	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	which	which	WDT	WDT	_	26	nsubjpass	_	_
24	can	can	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	induced	induce	VBN	VBN	_	21	acl:relcl	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	differentiate	differentiate	VB	VB	_	26	xcomp	_	_
29	into	into	IN	IN	_	31	case	_	_
30	hemoglobin-producing	hemoglobin-producing	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	megakaryocytes	megakaryocyte	NNS	NNS	_	31	conj	_	_
34	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	AML1a-transfected	aml1a-transfected	JJ	JJ	_	4	amod	_	_
3	K562	k562	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	reduced	reduce	VBN	VBN	_	8	amod	_	_
8	capacity	capacity	NN	NN	_	5	dobj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	differentiate	differentiate	VB	VB	_	8	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	sodium	sodium	NN	NN	_	16	compound	_	_
16	n-butyrate	n-butyrate	NN	NN	_	13	nmod	_	_
17	but	but	CC	CC	_	13	cc	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	13	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	other	other	JJ	JJ	_	24	amod	_	_
24	inducers	inducer	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	such	such	JJ	JJ	_	28	case	_	_
27	as	as	IN	IN	_	26	mwe	_	_
28	hemin	hemin	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	1-beta-D-arabinofuranosylcytosine	1-beta-d-arabinofuranosylcytosine	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	herbimycin	herbimycin	NN	NN	_	34	compound	_	_
34	A	a	NN	NN	_	28	conj	_	_
35	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	AML1	aml1	NN	NN	_	4	compound	_	_
3	antisense	antisense	JJ	JJ	_	4	amod	_	_
4	oligodeoxynucleotide	oligodeoxynucleotide	NN	NN	_	10	nsubj	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	4	cc	_	_
7	the	the	DT	DT	_	9	det	_	_
8	sense	sense	NN	NN	_	9	compound	_	_
9	oligomer	oligomer	NN	NN	_	4	conj	_	_
10	recovered	recover	VBD	VBD	_	0	root	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	differentiation-inducing	differentiation-inducing	JJ	JJ	_	13	amod	_	_
13	capacity	capacity	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	butyrate	butyrate	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	AML1b	aml1b	NN	NN	_	7	nsubj	_	_
7	conferred	confer	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	similar	similar	JJ	JJ	_	11	amod	_	_
10	differentiation-inducing	differentiation-inducing	JJ	JJ	_	9	dep	_	_
11	capacity	capacity	NN	NN	_	7	dobj	_	_
12	upon	upon	IN	IN	_	14	case	_	_
13	K562	k562	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	transfected	transfect	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	17	case	_	_
17	vector	vector	NN	NN	_	15	nmod	_	_
18	alone	alone	RB	RB	_	17	advmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	AML1a	aml1a	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	enhanced	enhance	VBN	VBN	_	7	amod	_	_
7	sensitivity	sensitivity	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	megakaryocytic	megakaryocytic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	nmod	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	phorbol	phorbol	NN	NN	_	14	compound	_	_
14	ester	ester	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	AML1	aml1	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	8	nsubj	_	_
8	play	play	VBP	VBP	_	4	ccomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	erythroid	erythroid	JJ	JJ	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	megakaryocytic	megakaryocytic	JJ	JJ	_	12	conj	_	_
15	differentiation	differentiation	NN	NN	_	12	dep	_	_
16	.	.	.	.	_	3	punct	_	_

1	Differentiation	differentiation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	U-937	u-937	NN	NN	_	5	compound	_	_
4	promonocytic	promonocytic	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	etoposide	etoposide	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	ICRF-193	icrf-193	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	two	two	CD	CD	_	16	nummod	_	_
12	antitumour	antitumour	JJ	JJ	_	16	amod	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	topoisomerase	topoisomerase	NN	NN	_	16	compound	_	_
15	II	ii	CD	CD	_	14	nummod	_	_
16	inhibitors	inhibitor	NNS	NNS	_	7	appos	_	_
17	with	with	IN	IN	_	19	case	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	action	action	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	compared	compare	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	action	action	NN	NN	_	3	dobj	_	_
6	on	on	IN	IN	_	11	case	_	_
7	U-937	u-937	NN	NN	_	11	compound	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	promonocytic	promonocytic	JJ	JJ	_	11	amod	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	two	two	CD	CD	_	17	nummod	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	topoisomerase	topoisomerase	NN	NN	_	17	compound	_	_
16	II	ii	CD	CD	_	15	nummod	_	_
17	inhibitors	inhibitor	NNS	NNS	_	5	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	namely	namely	RB	RB	_	22	advmod	_	_
20	the	the	DT	DT	_	22	det	_	_
21	epipodophyllotoxin	epipodophyllotoxin	NN	NN	_	22	compound	_	_
22	etoposide	etoposide	NN	NN	_	17	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	bisdioxopiperazine	bisdioxopiperazine	NN	NN	_	26	compound	_	_
26	ICRF-193	icrf-193	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	2	compound	_	_
2	hour	hour	NN	NN	_	3	amod	_	_
3	pulse-treatment	pulse-treatment	NN	NN	_	8	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	3	3	CD	CD	_	6	compound	_	_
6	microM	microm	NN	NN	_	7	amod	_	_
7	etoposide	etoposide	NN	NN	_	3	nmod	_	_
8	caused	cause	VBD	VBD	_	0	root	_	_
9	topoisomerase	topoisomerase	NN	NN	_	10	nmod:npmod	_	_
10	associated	associated	JJ	JJ	_	14	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	primary	primary	JJ	JJ	_	10	dep	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	breakage	breakage	NN	NN	_	8	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	19	nsubjpass	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	rapidly	rapidly	RB	RB	_	19	advmod	_	_
19	followed	follow	VBN	VBN	_	14	acl:relcl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	8	nsubjpass	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	upon	upon	IN	IN	_	10	case	_	_
10	pulse-treatment	pulse-treatment	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	6	6	CD	CD	_	13	compound	_	_
13	microM	microm	NN	NN	_	14	amod	_	_
14	ICRF-193	icrf-193	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	continuous	continuous	JJ	JJ	_	4	amod	_	_
4	treatments	treatment	NNS	NNS	_	20	nsubj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	subcytotoxic	subcytotoxic	JJ	JJ	_	7	amod	_	_
7	concentrations	concentration	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	etoposide	etoposide	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	0.15	0.15	CD	CD	_	12	nummod	_	_
12	microM	microm	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	ICRF-193	icrf-193	NN	NN	_	9	conj	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	0.3	0.3	CD	CD	_	18	nummod	_	_
18	microM	microm	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	produced	produce	VBD	VBD	_	0	root	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	similar	similar	JJ	JJ	_	23	amod	_	_
23	effects	effect	NNS	NNS	_	20	dobj	_	_
24	,	,	,	,	_	23	punct	_	_
25	namely	namely	RB	RB	_	28	advmod	_	_
26	decreased	decrease	VBN	VBN	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	proliferation	proliferation	NN	NN	_	23	appos	_	_
29	,	,	,	,	_	28	punct	_	_
30	accumulation	accumulation	NN	NN	_	28	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	cells	cell	NNS	NNS	_	30	nmod	_	_
33	at	at	IN	IN	_	34	case	_	_
34	G2	g2	NN	NN	_	30	nmod	_	_
35	,	,	,	,	_	28	punct	_	_
36	increase	increase	NN	NN	_	28	conj	_	_
37	in	in	IN	IN	_	39	case	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	mass	mass	NN	NN	_	36	nmod	_	_
40	,	,	,	,	_	28	punct	_	_
41	and	and	CC	CC	_	28	cc	_	_
42	induction	induction	NN	NN	_	28	conj	_	_
43	of	of	IN	IN	_	44	case	_	_
44	differentiation	differentiation	NN	NN	_	42	nmod	_	_
45	.	.	.	.	_	20	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	conditions	condition	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	etoposide	etoposide	NN	NN	_	6	nsubj	_	_
6	produced	produce	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	biphasic	biphasic	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	C	c	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	consisted	consist	VBD	VBD	_	9	acl:relcl	_	_
17	in	in	IN	IN	_	21	case	_	_
18	an	a	DT	DT	_	21	det	_	_
19	early	early	JJ	JJ	_	21	amod	_	_
20	transient	transient	JJ	JJ	_	19	dep	_	_
21	activation	activation	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	from	from	IN	IN	_	24	case	_	_
24	hours	hour	NNS	NNS	_	21	nmod	_	_
25	1	1	CD	CD	_	27	compound	_	_
26	to	to	TO	TO	_	27	dep	_	_
27	6	6	CD	CD	_	24	nummod	_	_
28	)	)	-RRB-	-RRB-	_	24	punct	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	membrane-bound	membrane-bound	JJ	JJ	_	32	amod	_	_
32	enzyme	enzyme	NN	NN	_	21	nmod	_	_
33	followed	follow	VBN	VBN	_	21	acl	_	_
34	by	by	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	later	later	JJ	JJ	_	37	amod	_	_
37	activation	activation	NN	NN	_	33	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	hour	hour	NN	NN	_	37	appos	_	_
40	48	48	CD	CD	_	39	nummod	_	_
41	)	)	-RRB-	-RRB-	_	39	punct	_	_
42	of	of	IN	IN	_	46	case	_	_
43	the	the	DT	DT	_	46	dep	_	_
44	total	total	JJ	JJ	_	46	amod	_	_
45	,	,	,	,	_	46	punct	_	_
46	membrane-bound	membrane-bound	JJ	JJ	_	37	nmod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	cytosolic	cytosolic	JJ	JJ	_	46	conj	_	_
49	enzyme	enzyme	NN	NN	_	46	dep	_	_
50	.	.	.	.	_	6	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	ICRF-193	icrf-193	NN	NN	_	6	nsubj	_	_
5	only	only	RB	RB	_	6	advmod	_	_
6	provoked	provoke	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	late	late	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	from	from	IN	IN	_	12	case	_	_
12	hours	hour	NNS	NNS	_	9	nmod	_	_
13	72	72	CD	CD	_	15	compound	_	_
14	to	to	TO	TO	_	15	dep	_	_
15	96	96	CD	CD	_	12	nummod	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	total	total	JJ	JJ	_	20	amod	_	_
20	enzyme	enzyme	NN	NN	_	9	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	used	use	VBN	VBN	_	10	advcl	_	_
3	at	at	IN	IN	_	5	case	_	_
4	differentiation-inducing	differentiation-inducing	JJ	JJ	_	5	amod	_	_
5	concentrations	concentration	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	both	both	DT	DT	_	9	det	_	_
8	topoisomerase	topoisomerase	NN	NN	_	9	compound	_	_
9	inhibitors	inhibitor	NNS	NNS	_	10	nsubj	_	_
10	caused	cause	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	great	great	JJ	JJ	_	13	amod	_	_
13	stimulation	stimulation	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	with	with	IN	IN	_	21	case	_	_
20	maximum	maximum	JJ	JJ	_	21	amod	_	_
21	value	value	NN	NN	_	13	nmod	_	_
22	at	at	IN	IN	_	23	case	_	_
23	hour	hour	NN	NN	_	21	nmod	_	_
24	12	12	CD	CD	_	23	nummod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	etoposide-treated	etoposide-treated	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	at	at	IN	IN	_	30	case	_	_
30	hour	hour	NN	NN	_	23	conj	_	_
31	48	48	CD	CD	_	30	nummod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	ICRF-193-treated	icrf-193-treated	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	23	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	19	nmod	_	_
3	,	,	,	,	_	19	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	19	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	B	b	NN	NN	_	6	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	EGR-1	egr-1	NN	NN	_	11	conj	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	11	dep	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	little	little	RB	RB	_	19	advmod	_	_
19	affected	affect	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	topoisomerase	topoisomerase	NN	NN	_	7	compound	_	_
6	II	ii	CD	CD	_	7	nummod	_	_
7	inhibitors	inhibitor	NNS	NNS	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	induce	induce	VB	VB	_	3	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	differentiation	differentiation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	promonocytic	promonocytic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	independently	independently	RB	RB	_	9	advmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	capacity	capacity	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	cause	cause	VB	VB	_	19	acl	_	_
22	DNA	dna	NN	NN	_	24	compound	_	_
23	strand	strand	NN	NN	_	24	compound	_	_
24	breaks	breaks	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	are	be	VBP	VBP	_	0	root	_	_
5	other	other	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	4	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	such	such	JJ	JJ	_	12	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	the	the	DT	DT	_	12	det	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	protein	protein	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	C	c	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	which	which	WDT	WDT	_	21	nsubjpass	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	probably	probably	RB	RB	_	21	advmod	_	_
21	derived	derive	VBN	VBN	_	6	acl:relcl	_	_
22	from	from	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	production	production	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	primary	primary	JJ	JJ	_	28	amod	_	_
27	DNA	dna	NN	NN	_	28	compound	_	_
28	breakage	breakage	NN	NN	_	24	nmod	_	_
29	by	by	IN	IN	_	32	case	_	_
30	some	some	DT	DT	_	32	det	_	_
31	anti-topoisomerase	anti-topoisomerase	JJ	JJ	_	32	amod	_	_
32	drugs	drug	NNS	NNS	_	24	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	Rel-A	rel-a	NN	NN	_	9	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	c-Rel	c-rel	NN	NN	_	2	conj	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	complexes	complex	NNS	NNS	_	2	dep	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	differentially	differentially	RB	RB	_	9	advmod	_	_
9	distributed	distribute	VBN	VBN	_	0	root	_	_
10	within	within	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	thymocytes	thymocyte	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	9	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	9	compound	_	_
3	B	b	NN	NN	_	9	compound	_	_
4	(	(	-LRB-	-LRB-	_	9	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
6	B	b	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	/Rel	/rel	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	13	nsubj	_	_
10	are	be	VBP	VBP	_	13	cop	_	_
11	inducible	inducible	JJ	JJ	_	13	amod	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	regulators	regulator	NNS	NNS	_	0	root	_	_
14	of	of	IN	IN	_	17	case	_	_
15	numerous	numerous	JJ	JJ	_	17	amod	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	They	they	PRP	PRP	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	particularly	particularly	RB	RB	_	4	advmod	_	_
4	abundant	abundant	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	thought	think	VBN	VBN	_	4	conj	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	critical	critical	JJ	JJ	_	10	xcomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	genes	gene	NNS	NNS	_	16	nmod	_	_
19	involved	involve	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	21	case	_	_
21	immune	immune	JJ	JJ	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	inflammatory	inflammatory	JJ	JJ	_	21	conj	_	_
24	responses	response	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	reported	report	VBN	VBN	_	0	root	_	_
4	previously	previously	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	a	a	DT	DT	_	10	det	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	12	nsubj	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	present	present	JJ	JJ	_	3	ccomp	_	_
13	in	in	IN	IN	_	17	case	_	_
14	freshly	freshly	RB	RB	_	15	advmod	_	_
15	extracted	extract	VBN	VBN	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	thymocytes	thymocyte	NNS	NNS	_	12	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	absence	absence	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	in	in	FW	FW	_	24	amod	_	_
23	vitro	vitro	FW	FW	_	22	dep	_	_
24	treatment	treatment	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	report	report	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	identified	identify	VBD	VBD	_	0	root	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	dobj	_	_
11	extracted	extract	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	thymocyte	thymocyte	NN	NN	_	15	compound	_	_
15	nuclei	nucleus	NNS	NNS	_	11	nmod	_	_
16	as	as	IN	IN	_	18	mark	_	_
17	being	be	VBG	VBG	_	18	cop	_	_
18	p50/p65	p50/p65	NN	NN	_	7	advcl	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	p50/c-Rel	p50/c-rel	NN	NN	_	18	conj	_	_
21	complexes	complex	NNS	NNS	_	18	dep	_	_
22	.	.	.	.	_	7	punct	_	_

1	Immunochemical	immunochemical	JJ	JJ	_	11	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	immunofluorescent	immunofluorescent	JJ	JJ	_	1	conj	_	_
4	staining	staining	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	thymus	thymus	NN	NN	_	7	compound	_	_
7	sections	section	NNS	NNS	_	4	nmod	_	_
8	using	use	VBG	VBG	_	4	acl	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	Abs	ab	NNS	NNS	_	8	dobj	_	_
11	allowed	allow	VBD	VBD	_	0	root	_	_
12	visualization	visualization	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	12	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	thymocytes	thymocyte	NNS	NNS	_	12	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	nonthymocyte	nonthymocyte	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	detection	detection	NN	NN	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	preferential	preferential	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p50/c-Rel	p50/c-rel	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	medullary	medullary	JJ	JJ	_	11	amod	_	_
11	thymocytes	thymocyte	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	whereas	whereas	IN	IN	_	16	mark	_	_
14	p50/p65	p50/p65	NN	NN	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	present	present	JJ	JJ	_	3	advcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	cortical	cortical	JJ	JJ	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	medullary	medullary	JJ	JJ	_	19	conj	_	_
22	regions	region	NNS	NNS	_	19	dep	_	_
23	of	of	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	thymus	thymus	NN	NN	_	26	compound	_	_
26	lobules	lobule	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	intensity	intensity	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	p65	p65	NN	NN	_	7	compound	_	_
7	labeling	labeling	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	much	much	RB	RB	_	10	advmod	_	_
10	higher	higher	JJR	JJR	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	several	several	JJ	JJ	_	13	amod	_	_
13	thymocytes	thymocyte	NNS	NNS	_	10	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	medulla	medulla	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	p65	p65	NN	NN	_	9	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	p50	p50	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	c-Rel	c-rel	NN	NN	_	1	conj	_	_
7	activities	activity	NNS	NNS	_	1	dep	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	CD4-	cd4-	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	CD8-positive	cd8-positive	JJ	JJ	_	12	conj	_	_
15	thymocytes	thymocyte	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	p65	p65	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-Rel	c-rel	NN	NN	_	5	conj	_	_
8	complexes	complex	NNS	NNS	_	5	dep	_	_
9	play	play	VBP	VBP	_	3	ccomp	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	roles	role	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	that	that	IN	IN	_	22	mark	_	_
17	both	both	DT	DT	_	18	det	_	_
18	forms	form	NNS	NNS	_	22	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	play	play	VBP	VBP	_	9	conj	_	_
23	critical	critical	JJ	JJ	_	24	amod	_	_
24	roles	role	NNS	NNS	_	22	dobj	_	_
25	during	during	IN	IN	_	27	case	_	_
26	late	late	JJ	JJ	_	27	amod	_	_
27	stages	stage	NNS	NNS	_	22	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	intrathymic	intrathymic	JJ	JJ	_	31	amod	_	_
31	maturation	maturation	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Alteration	alteration	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	single	single	JJ	JJ	_	5	amod	_	_
5	serine	serine	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	basic	basic	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	1	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	Epstein-Barr	epstein-barr	JJ	JJ	_	15	amod	_	_
13	virus	virus	NN	NN	_	15	compound	_	_
14	ZEBRA	zebra	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	9	nmod	_	_
16	separates	separate	VBZ	VBZ	_	0	root	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	functions	function	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	disruption	disruption	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	latency	latency	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ZEBRA	zebra	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	10	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	6	amod	_	_
6	virus	virus	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EBV	ebv	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	activates	activate	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	12	det	_	_
12	switch	switch	NN	NN	_	10	dobj	_	_
13	from	from	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	latent	latent	JJ	JJ	_	12	nmod	_	_
16	to	to	TO	TO	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	lytic	lytic	JJ	JJ	_	20	amod	_	_
19	expression	expression	NN	NN	_	20	compound	_	_
20	program	program	NN	NN	_	12	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	virus	virus	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	ZEBRA	zebra	NN	NN	_	16	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	member	member	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	bZIP	bzip	NN	NN	_	8	compound	_	_
8	family	family	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activator	activator	NN	NN	_	0	root	_	_
17	capable	capable	JJ	JJ	_	16	amod	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	inducing	induce	VBG	VBG	_	17	advcl	_	_
20	expression	expression	NN	NN	_	19	dobj	_	_
21	from	from	IN	IN	_	25	case	_	_
22	viral	viral	JJ	JJ	_	25	amod	_	_
23	lytic	lytic	JJ	JJ	_	25	amod	_	_
24	cycle	cycle	NN	NN	_	25	compound	_	_
25	promoters	promoter	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	had	have	VBD	VBD	_	5	aux	_	_
3	previously	previously	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	thought	think	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	ZEBRA	zebra	NN	NN	_	9	nmod:poss	_	_
8	's	's	POS	POS	_	7	case	_	_
9	capacity	capacity	NN	NN	_	14	nsubj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	disrupt	disrupt	VB	VB	_	9	acl	_	_
12	EBV	ebv	NN	NN	_	13	compound	_	_
13	latency	latency	NN	NN	_	11	dobj	_	_
14	resided	reside	VBD	VBD	_	5	ccomp	_	_
15	primarily	primarily	RB	RB	_	18	advmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	ability	ability	NN	NN	_	14	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	activate	activate	VB	VB	_	18	acl	_	_
21	transcription	transcription	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	genes	gene	NNS	NNS	_	21	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	encode	encode	VBP	VBP	_	23	acl:relcl	_	_
26	products	product	NNS	NNS	_	25	dobj	_	_
27	required	require	VBN	VBN	_	26	acl	_	_
28	for	for	IN	IN	_	30	case	_	_
29	lytic	lytic	JJ	JJ	_	30	amod	_	_
30	replication	replication	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	generated	generate	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	point	point	NN	NN	_	5	compound	_	_
5	mutant	mutant	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	ZEBRA	zebra	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	Z	z	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	S186A	s186a	NN	NN	_	5	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	5	punct	_	_
14	that	that	WDT	WDT	_	17	nsubj	_	_
15	was	be	VBD	VBD	_	17	cop	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	impaired	impaired	JJ	JJ	_	5	acl:relcl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	ability	ability	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	activate	activate	VB	VB	_	20	acl	_	_
23	transcription	transcription	NN	NN	_	22	dobj	_	_
24	;	;	:	:	_	2	punct	_	_
25	however	however	RB	RB	_	29	advmod	_	_
26	,	,	,	,	_	29	punct	_	_
27	this	this	DT	DT	_	28	det	_	_
28	mutation	mutation	NN	NN	_	29	nsubj	_	_
29	abolished	abolish	VBD	VBD	_	2	parataxis	_	_
30	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
31	ability	ability	NN	NN	_	29	dobj	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	initiate	initiate	VB	VB	_	31	acl	_	_
34	the	the	DT	DT	_	37	det	_	_
35	viral	viral	JJ	JJ	_	37	amod	_	_
36	lytic	lytic	JJ	JJ	_	35	dep	_	_
37	cascade	cascade	NN	NN	_	33	dobj	_	_
38	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mutant	mutant	NN	NN	_	16	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	containing	contain	VBG	VBG	_	2	acl	_	_
5	a	a	DT	DT	_	7	det	_	_
6	serine-to-alanine	serine-to-alanine	JJ	JJ	_	7	amod	_	_
7	substitution	substitution	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	protein	protein	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	bound	bind	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	21	case	_	_
18	several	several	JJ	JJ	_	21	amod	_	_
19	known	known	JJ	JJ	_	21	amod	_	_
20	ZEBRA-binding	zebra-binding	JJ	JJ	_	21	amod	_	_
21	sites	site	NNS	NNS	_	16	nmod	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	activated	activate	VBD	VBD	_	16	conj	_	_
24	transcription	transcription	NN	NN	_	23	dobj	_	_
25	from	from	IN	IN	_	26	case	_	_
26	reporters	reporter	NNS	NNS	_	23	nmod	_	_
27	bearing	bear	VBG	VBG	_	26	acl	_	_
28	known	known	JJ	JJ	_	30	amod	_	_
29	ZEBRA-responsive	zebra-responsive	JJ	JJ	_	30	amod	_	_
30	promoters	promoter	NNS	NNS	_	27	dobj	_	_
31	but	but	CC	CC	_	16	cc	_	_
32	did	do	VBD	VBD	_	34	aux	_	_
33	not	not	RB	RB	_	34	neg	_	_
34	disrupt	disrupt	VB	VB	_	16	conj	_	_
35	latency	latency	NN	NN	_	34	dobj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	EBV-infected	ebv-infected	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	lines	line	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	16	punct	_	_

1	Therefore	therefore	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	initiation	initiation	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	EBV	ebv	NN	NN	_	8	compound	_	_
7	lytic	lytic	JJ	JJ	_	8	amod	_	_
8	cycle	cycle	NN	NN	_	3	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ZEBRA	zebra	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	3	nmod	_	_
13	requires	require	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	function	function	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	addition	addition	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	;	;	:	:	_	13	punct	_	_
22	a	a	DT	DT	_	23	det	_	_
23	change	change	NN	NN	_	35	nsubj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	serine	serine	NN	NN	_	23	nmod	_	_
26	186	186	CD	CD	_	25	nummod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	alanine	alanine	NN	NN	_	23	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	DNA-binding	dna-binding	JJ	JJ	_	32	amod	_	_
32	domain	domain	NN	NN	_	23	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	ZEBRA	zebra	NN	NN	_	32	nmod	_	_
35	abolished	abolish	VBD	VBD	_	13	parataxis	_	_
36	this	this	DT	DT	_	38	det	_	_
37	additional	additional	JJ	JJ	_	38	amod	_	_
38	function	function	NN	NN	_	35	dobj	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	uncovered	uncover	VBD	VBD	_	35	conj	_	_
41	a	a	DT	DT	_	43	det	_	_
42	new	new	JJ	JJ	_	43	amod	_	_
43	role	role	NN	NN	_	40	dobj	_	_
44	for	for	IN	IN	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	ZEBRA	zebra	NN	NN	_	47	compound	_	_
47	protein	protein	NN	NN	_	43	nmod	_	_
48	in	in	IN	IN	_	49	case	_	_
49	disruption	disruption	NN	NN	_	40	nmod	_	_
50	of	of	IN	IN	_	52	case	_	_
51	EBV	ebv	NN	NN	_	52	compound	_	_
52	latency	latency	NN	NN	_	49	nmod	_	_
53	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	additional	additional	JJ	JJ	_	3	amod	_	_
3	function	function	NN	NN	_	16	nsubj	_	_
4	that	that	WDT	WDT	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	3	acl:relcl	_	_
7	for	for	IN	IN	_	8	case	_	_
8	initiation	initiation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	lytic	lytic	JJ	JJ	_	14	amod	_	_
12	viral	viral	JJ	JJ	_	11	dep	_	_
13	life	life	NN	NN	_	14	compound	_	_
14	cycle	cycle	NN	NN	_	8	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	likely	likely	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	require	require	VB	VB	_	16	xcomp	_	_
19	phosphorylation	phosphorylation	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	serine	serine	NN	NN	_	19	nmod	_	_
22	186	186	CD	CD	_	21	nummod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	ZEBRA	zebra	NN	NN	_	26	compound	_	_
26	protein	protein	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	19	punct	_	_
28	which	which	WDT	WDT	_	30	nsubj	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	influence	influence	VB	VB	_	19	acl:relcl	_	_
31	either	either	CC	CC	_	33	cc:preconj	_	_
32	DNA	dna	NN	NN	_	33	compound	_	_
33	recognition	recognition	NN	NN	_	30	dobj	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	transcriptional	transcriptional	JJ	JJ	_	36	amod	_	_
36	activation	activation	NN	NN	_	33	conj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	lytic	lytic	JJ	JJ	_	40	amod	_	_
39	viral	viral	JJ	JJ	_	40	amod	_	_
40	promoters	promoter	NNS	NNS	_	33	nmod	_	_
41	in	in	IN	IN	_	45	case	_	_
42	a	a	DT	DT	_	45	det	_	_
43	chromatinized	chromatinize	VBN	VBN	_	45	amod	_	_
44	viral	viral	JJ	JJ	_	45	amod	_	_
45	episome	episome	NN	NN	_	33	nmod	_	_
46	.	.	.	.	_	16	punct	_	_

1	Redox	redox	NN	NN	_	2	compound	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	mitogen-activated	mitogen-activated	JJ	JJ	_	7	amod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	2	nmod	_	_
9	during	during	IN	IN	_	11	case	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	obligatory	obligatory	JJ	JJ	_	7	amod	_	_
7	requirement	requirement	NN	NN	_	4	dobj	_	_
8	for	for	IN	IN	_	13	case	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	reactive	reactive	JJ	JJ	_	13	amod	_	_
11	oxygen	oxygen	NN	NN	_	13	compound	_	_
12	species	species	NNS	NNS	_	13	compound	_	_
13	generation	generation	NN	NN	_	7	nmod	_	_
14	during	during	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	have	have	VBP	VBP	_	21	aux	_	_
21	proposed	propose	VBN	VBN	_	4	conj	_	_
22	that	that	IN	IN	_	28	mark	_	_
23	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
24	reactive	reactive	JJ	JJ	_	26	amod	_	_
25	oxygen	oxygen	NN	NN	_	26	compound	_	_
26	species	species	NNS	NNS	_	28	nsubj	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	act	act	VB	VB	_	21	ccomp	_	_
29	as	as	IN	IN	_	31	case	_	_
30	signalling	signalling	NN	NN	_	31	compound	_	_
31	agents	agent	NNS	NNS	_	28	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	regulation	regulation	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	certain	certain	JJ	JJ	_	37	amod	_	_
37	cellular	cellular	JJ	JJ	_	38	amod	_	_
38	processes	process	NNS	NNS	_	34	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	for	for	IN	IN	_	41	case	_	_
41	example	example	NN	NN	_	38	nmod	_	_
42	,	,	,	,	_	38	punct	_	_
43	during	during	IN	IN	_	46	case	_	_
44	cell	cell	NN	NN	_	46	compound	_	_
45	cycle	cycle	NN	NN	_	46	compound	_	_
46	entry	entry	NN	NN	_	38	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	9	nsubjpass	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	interested	interest	VBN	VBN	_	2	parataxis	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	determine	determine	VB	VB	_	9	xcomp	_	_
12	which	which	WP	WP	_	22	nsubjpass	_	_
13	,	,	,	,	_	22	punct	_	_
14	if	if	IN	IN	_	15	mark	_	_
15	any	any	DT	DT	_	22	dep	_	_
16	,	,	,	,	_	22	punct	_	_
17	cell	cell	NN	NN	_	20	compound	_	_
18	cycle	cycle	NN	NN	_	20	compound	_	_
19	entry	entry	NN	NN	_	20	compound	_	_
20	events	event	NNS	NNS	_	22	dep	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	affected	affect	VBN	VBN	_	11	advcl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	oxidative	oxidative	JJ	JJ	_	25	amod	_	_
25	signalling	signalling	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	earlier	earlier	JJR	JJR	_	3	amod	_	_
3	studies	study	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	dobj	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	AP-1	ap-1	NN	NN	_	12	conj	_	_
15	as	as	IN	IN	_	17	case	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	targets	target	NNS	NNS	_	7	nmod	_	_
18	for	for	IN	IN	_	21	case	_	_
19	oxidative	oxidative	JJ	JJ	_	21	amod	_	_
20	signalling	signalling	NN	NN	_	21	compound	_	_
21	processes	process	NNS	NNS	_	17	nmod	_	_
22	during	during	IN	IN	_	25	case	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	cycle	cycle	NN	NN	_	25	compound	_	_
25	entry	entry	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	7	punct	_	_
27	and	and	CC	CC	_	7	cc	_	_
28	have	have	VBP	VBP	_	29	aux	_	_
29	shown	show	VBN	VBN	_	7	conj	_	_
30	that	that	IN	IN	_	34	mark	_	_
31	oxidative	oxidative	JJ	JJ	_	32	amod	_	_
32	signalling	signalling	NN	NN	_	34	nsubjpass	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	involved	involve	VBN	VBN	_	29	ccomp	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	regulation	regulation	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	early	early	JJ	JJ	_	40	amod	_	_
40	changes	change	NNS	NNS	_	37	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	gene	gene	NN	NN	_	43	compound	_	_
43	expression	expression	NN	NN	_	40	nmod	_	_
44	during	during	IN	IN	_	50	case	_	_
45	the	the	DT	DT	_	50	det	_	_
46	G0	g0	NN	NN	_	50	compound	_	_
47	to	to	TO	TO	_	48	case	_	_
48	G1	g1	NN	NN	_	46	nmod	_	_
49	phase	phase	NN	NN	_	50	compound	_	_
50	transition	transition	NN	NN	_	40	nmod	_	_
51	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	extend	extend	VB	VB	_	0	root	_	_
3	these	these	DT	DT	_	5	det	_	_
4	initial	initial	JJ	JJ	_	5	amod	_	_
5	observations	observation	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	examined	examine	VBN	VBN	_	2	parataxis	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effect	effect	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	antioxidant	antioxidant	JJ	JJ	_	14	amod	_	_
14	treatment	treatment	NN	NN	_	11	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activity	activity	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	mitogen-activated	mitogen-activated	JJ	JJ	_	22	amod	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	kinases	kinase	NNS	NNS	_	17	nmod	_	_
23	erk1	erk1	NN	NN	_	22	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	erk2	erk2	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	9	punct	_	_
27	as	as	IN	IN	_	28	case	_	_
28	members	member	NNS	NNS	_	9	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	a	a	DT	DT	_	33	det	_	_
31	signal	signal	NN	NN	_	33	compound	_	_
32	transduction	transduction	NN	NN	_	33	compound	_	_
33	pathway	pathway	NN	NN	_	28	nmod	_	_
34	known	know	VBN	VBN	_	33	acl	_	_
35	to	to	TO	TO	_	37	mark	_	_
36	directly	directly	RB	RB	_	37	advmod	_	_
37	regulate	regulate	VB	VB	_	34	xcomp	_	_
38	transcription	transcription	NN	NN	_	40	compound	_	_
39	factor	factor	NN	NN	_	40	compound	_	_
40	function	function	NN	NN	_	37	dobj	_	_
41	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	as	as	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	probe	probe	NN	NN	_	1	nmod	_	_
5	cysteamine	cysteamine	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	an	a	DT	DT	_	9	det	_	_
8	aminothiol	aminothiol	NN	NN	_	9	compound	_	_
9	compound	compound	NN	NN	_	5	appos	_	_
10	with	with	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	antioxidant	antioxidant	JJ	JJ	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	antiproliferative	antiproliferative	JJ	JJ	_	12	conj	_	_
15	activity	activity	NN	NN	_	12	dep	_	_
16	,	,	,	,	_	1	punct	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	identified	identify	VBN	VBN	_	1	parataxis	_	_
20	erk2	erk2	NN	NN	_	19	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	24	det	_	_
23	key	key	JJ	JJ	_	24	amod	_	_
24	element	element	NN	NN	_	20	appos	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	MAP	map	NN	NN	_	29	compound	_	_
28	kinase	kinase	NN	NN	_	29	compound	_	_
29	pathway	pathway	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	19	punct	_	_
31	as	as	IN	IN	_	33	mark	_	_
32	being	be	VBG	VBG	_	33	cop	_	_
33	responsive	responsive	JJ	JJ	_	19	advcl	_	_
34	to	to	TO	TO	_	36	case	_	_
35	oxidative	oxidative	JJ	JJ	_	36	amod	_	_
36	signalling	signalling	NN	NN	_	33	nmod	_	_
37	during	during	IN	IN	_	39	case	_	_
38	lymphocyte	lymphocyte	NN	NN	_	39	compound	_	_
39	activation	activation	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	further	further	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	suggest	suggest	VB	VB	_	5	acl	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	for	for	IN	IN	_	13	case	_	_
11	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
12	oxidant	oxidant	JJ	JJ	_	13	amod	_	_
13	generation	generation	NN	NN	_	9	nmod	_	_
14	as	as	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	mechanism	mechanism	NN	NN	_	9	nmod	_	_
18	during	during	IN	IN	_	21	case	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	cycle	cycle	NN	NN	_	21	compound	_	_
21	entry	entry	NN	NN	_	9	nmod	_	_
22	,	,	,	,	_	3	punct	_	_
23	and	and	CC	CC	_	3	cc	_	_
24	establish	establish	VBP	VBP	_	3	conj	_	_
25	a	a	DT	DT	_	26	det	_	_
26	link	link	NN	NN	_	24	dobj	_	_
27	between	between	IN	IN	_	29	case	_	_
28	oxidative	oxidative	JJ	JJ	_	29	amod	_	_
29	signalling	signalling	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	other	other	JJ	JJ	_	32	amod	_	_
32	aspects	aspect	NNS	NNS	_	29	conj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	intracellular	intracellular	JJ	JJ	_	37	amod	_	_
36	signalling	signalling	NN	NN	_	37	compound	_	_
37	network	network	NN	NN	_	32	nmod	_	_
38	that	that	WDT	WDT	_	40	nsubjpass	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	activated	activate	VBN	VBN	_	37	acl:relcl	_	_
41	in	in	IN	IN	_	42	case	_	_
42	response	response	NN	NN	_	40	nmod	_	_
43	to	to	TO	TO	_	45	case	_	_
44	mitogenic	mitogenic	JJ	JJ	_	45	amod	_	_
45	stimulation	stimulation	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	3	punct	_	_

1	Common	common	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	distinct	distinct	JJ	JJ	_	1	conj	_	_
4	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
5	signaling	signaling	NN	NN	_	6	compound	_	_
6	pathways	pathway	NNS	NNS	_	1	dep	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	neutrophils	neutrophil	NNS	NNS	_	1	nmod	_	_
10	utilized	utilize	VBN	VBN	_	1	acl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	platelet	platelet	NN	NN	_	14	compound	_	_
13	activating	activating	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	FMLP	fmlp	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	1	punct	_	_

1	Stimulation	stimulation	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	neutrophils	neutrophil	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	chemoattractants	chemoattractant	NNS	NNS	_	1	nmod	_	_
7	FMLP	fmlp	NN	NN	_	6	dep	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	platelet	platelet	NN	NN	_	11	compound	_	_
10	activating	activating	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	7	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PAF	paf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	results	result	VBZ	VBZ	_	0	root	_	_
16	in	in	IN	IN	_	21	case	_	_
17	different	different	JJ	JJ	_	21	amod	_	_
18	but	but	CC	CC	_	17	cc	_	_
19	overlapping	overlap	VBG	VBG	_	17	conj	_	_
20	functional	functional	JJ	JJ	_	21	amod	_	_
21	responses	response	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	questioned	question	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	7	mark	_	_
4	these	these	DT	DT	_	5	det	_	_
5	differences	difference	NNS	NNS	_	7	nsubj	_	_
6	might	might	MD	MD	_	7	aux	_	_
7	reflect	reflect	VB	VB	_	2	ccomp	_	_
8	patterns	pattern	NNS	NNS	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
11	signal	signal	NN	NN	_	12	compound	_	_
12	transduction	transduction	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	7	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	either	either	CC	CC	_	4	cc:preconj	_	_
4	PAF	paf	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	FMLP	fmlp	NN	NN	_	4	conj	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	equivalent	equivalent	JJ	JJ	_	10	amod	_	_
10	phosphorylation	phosphorylation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	activation	activation	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	21	case	_	_
14	the	the	DT	DT	_	21	det	_	_
15	mitogen-activated	mitogen-activated	JJ	JJ	_	21	amod	_	_
16	protein	protein	NN	NN	_	21	compound	_	_
17	kinase	kinase	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	MAPk	mapk	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	homologue	homologue	NN	NN	_	12	nmod	_	_
22	38-kD	38-kd	JJ	JJ	_	25	amod	_	_
23	murine	murine	JJ	JJ	_	25	amod	_	_
24	MAP	map	NN	NN	_	25	compound	_	_
25	kinase	kinase	NN	NN	_	21	dep	_	_
26	homologous	homologous	JJ	JJ	_	25	amod	_	_
27	to	to	TO	TO	_	32	case	_	_
28	HOG-1	hog-1	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	p38	p38	NN	NN	_	32	compound	_	_
31	)	)	-RRB-	-RRB-	_	32	punct	_	_
32	MAPk	mapk	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	FMLP	fmlp	NN	NN	_	5	nsubj	_	_
3	nor	nor	CC	CC	_	2	cc	_	_
4	PAF	paf	NN	NN	_	2	conj	_	_
5	activated	activate	VBD	VBD	_	0	root	_	_
6	c-jun	c-jun	NN	NN	_	8	compound	_	_
7	NH2-terminal	nh2-terminal	JJ	JJ	_	8	amod	_	_
8	MAPk	mapk	NN	NN	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	JNKs	jnk	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	.	.	.	.	_	5	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	identical	identical	JJ	JJ	_	3	amod	_	_
3	conditions	condition	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	FMLP	fmlp	NN	NN	_	10	nsubj	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	5	cc	_	_
8	PAF	paf	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	resulted	result	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	18	case	_	_
12	significant	significant	JJ	JJ	_	18	amod	_	_
13	p42/44	p42/44	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	ERK	erk	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	MAPk	mapk	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	FMLP	fmlp	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	PAF	paf	NN	NN	_	2	conj	_	_
5	activated	activate	VBD	VBD	_	0	root	_	_
6	MAP	map	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	kinase-3	kinase-3	NN	NN	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MKK3	mkk3	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	a	a	DT	DT	_	15	det	_	_
14	known	known	JJ	JJ	_	15	amod	_	_
15	activator	activator	NN	NN	_	8	appos	_	_
16	of	of	IN	IN	_	18	case	_	_
17	p38	p38	NN	NN	_	18	compound	_	_
18	MAPk	mapk	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Both	both	CC	CC	_	5	cc:preconj	_	_
2	MAP	map	NN	NN	_	5	compound	_	_
3	ERK	erk	NN	NN	_	5	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	kinase-1	kinase-1	NN	NN	_	12	nsubjpass	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MEKK1	mekk1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	Raf	raf	NN	NN	_	5	conj	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	activated	activate	VBN	VBN	_	0	root	_	_
13	strongly	strongly	RB	RB	_	15	advmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	FMLP	fmlp	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	15	cc	_	_
18	minimally	minimally	RB	RB	_	20	advmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	PAF	paf	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	12	punct	_	_

1	Pertussis	pertussis	NN	NN	_	2	compound	_	_
2	toxin	toxin	NN	NN	_	3	nsubj	_	_
3	blocked	block	VBD	VBD	_	0	root	_	_
4	FMLP-induced	fmlp-induced	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	p42/44	p42/44	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	ERK	erk	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	MAPk	mapk	NN	NN	_	13	compound	_	_
13	cascade	cascade	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	but	but	CC	CC	_	16	cc	_	_
16	not	not	RB	RB	_	5	cc	_	_
17	that	that	DT	DT	_	5	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	p38	p38	NN	NN	_	20	compound	_	_
20	MAPk	mapk	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	specific	specific	JJ	JJ	_	5	amod	_	_
3	p38	p38	NN	NN	_	4	compound	_	_
4	MAPk	mapk	NN	NN	_	5	compound	_	_
5	inhibitor	inhibitor	NN	NN	_	10	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	SK&amp;F	sk&amp;f	NN	NN	_	5	appos	_	_
8	86002	86002	CD	CD	_	7	nummod	_	_
9	)	)	-RRB-	-RRB-	_	7	punct	_	_
10	blocked	block	VBD	VBD	_	0	root	_	_
11	superoxide	superoxide	NN	NN	_	13	compound	_	_
12	anion	anion	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	10	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	FMLP	fmlp	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	reduced	reduce	VBD	VBD	_	10	conj	_	_
20	adhesion	adhesion	NN	NN	_	19	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	chemotaxis	chemotaxis	NN	NN	_	20	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	response	response	NN	NN	_	19	nmod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	PAF	paf	NN	NN	_	24	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	FMLP	fmlp	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	patterns	pattern	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	intracellular	intracellular	JJ	JJ	_	8	amod	_	_
8	signaling	signaling	NN	NN	_	5	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	chemoattractants	chemoattractant	NNS	NNS	_	5	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	suggest	suggest	VBP	VBP	_	3	conj	_	_
14	that	that	IN	IN	_	22	mark	_	_
15	selective	selective	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	22	nsubj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
19	signaling	signaling	NN	NN	_	20	compound	_	_
20	cascades	cascade	NNS	NNS	_	16	nmod	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	underlie	underlie	VB	VB	_	13	ccomp	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	patterns	pattern	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	functional	functional	JJ	JJ	_	27	amod	_	_
27	responses	response	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	an	a	DT	DT	_	7	det	_	_
5	interleukin-12	interleukin-12	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	component	component	NN	NN	_	2	nmod	_	_
8	by	by	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	helper	helper	NN	NN	_	13	compound	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	cells	cell	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Interleukin-12	interleukin-12	NN	NN	_	17	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-12	il-12	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	heterodimeric	heterodimeric	JJ	JJ	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	1	appos	_	_
9	produced	produce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	dendritic	dendritic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	,	,	,	,	_	1	punct	_	_
17	plays	play	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	crucial	crucial	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	regulating	regulate	VBG	VBG	_	17	nmod	_	_
23	interferon	interferon	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	27	punct	_	_
25	IFN	ifn	NN	NN	_	27	compound	_	_
26	)	)	-RRB-	-RRB-	_	27	punct	_	_
27	-gamma	-gamma	NN	NN	_	28	compound	_	_
28	production	production	NN	NN	_	22	dobj	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	generation	generation	NN	NN	_	22	conj	_	_
33	of	of	IN	IN	_	41	case	_	_
34	IFN-gamma-producing	ifn-gamma-producing	JJ	JJ	_	41	amod	_	_
35	T	t	NN	NN	_	41	compound	_	_
36	helper	helper	NN	NN	_	41	compound	_	_
37	1	1	CD	CD	_	41	nummod	_	_
38	(	(	-LRB-	-LRB-	_	41	punct	_	_
39	Th1	th1	NN	NN	_	41	compound	_	_
40	)	)	-RRB-	-RRB-	_	41	punct	_	_
41	cells	cell	NNS	NNS	_	32	nmod	_	_
42	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	28	mark	_	_
5	the	the	DT	DT	_	13	det	_	_
6	IL-12	il-12	NN	NN	_	13	compound	_	_
7	receptor	receptor	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	IL-12R	il-12r	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	beta	beta	NN	NN	_	13	compound	_	_
12	2	2	CD	CD	_	13	nummod	_	_
13	subunit	subunit	NN	NN	_	28	nsubjpass	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	18	dep	_	_
16	recently	recently	RB	RB	_	18	advmod	_	_
17	cloned	clone	VBN	VBN	_	18	amod	_	_
18	binding	binding	NN	NN	_	13	appos	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	signal	signal	NN	NN	_	21	compound	_	_
21	transducing	transducing	NN	NN	_	18	conj	_	_
22	component	component	NN	NN	_	18	dep	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	IL-12R	il-12r	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	13	punct	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	expressed	express	VBN	VBN	_	3	ccomp	_	_
29	on	on	IN	IN	_	31	case	_	_
30	human	human	JJ	JJ	_	31	amod	_	_
31	Th1	th1	NN	NN	_	28	nmod	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	31	cc	_	_
34	Th2	th2	NN	NN	_	31	conj	_	_
35	clones	clone	NNS	NNS	_	31	dep	_	_
36	and	and	CC	CC	_	28	cc	_	_
37	is	be	VBZ	VBZ	_	38	auxpass	_	_
38	induced	induce	VBN	VBN	_	28	conj	_	_
39	during	during	IN	IN	_	40	case	_	_
40	differentiation	differentiation	NN	NN	_	38	nmod	_	_
41	of	of	IN	IN	_	44	case	_	_
42	human	human	JJ	JJ	_	44	amod	_	_
43	naive	naive	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	40	nmod	_	_
45	along	along	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	Th1	th1	NN	NN	_	44	nmod	_	_
48	but	but	CC	CC	_	49	cc	_	_
49	not	not	RB	RB	_	47	cc	_	_
50	the	the	DT	DT	_	51	det	_	_
51	Th2	th2	NN	NN	_	47	conj	_	_
52	pathway	pathway	NN	NN	_	47	dep	_	_
53	.	.	.	.	_	3	punct	_	_

1	IL-12	il-12	NN	NN	_	10	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	type	type	NN	NN	_	1	conj	_	_
4	I	i	CD	CD	_	3	nummod	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	3	cc	_	_
7	type	type	NN	NN	_	3	conj	_	_
8	II	ii	CD	CD	_	7	nummod	_	_
9	interferons	interferon	NNS	NNS	_	3	dep	_	_
10	induce	induce	VBP	VBP	_	0	root	_	_
11	expression	expression	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	IL-12R	il-12r	NN	NN	_	17	compound	_	_
15	beta	beta	NN	NN	_	17	compound	_	_
16	2	2	CD	CD	_	17	nummod	_	_
17	chain	chain	NN	NN	_	11	nmod	_	_
18	during	during	IN	IN	_	23	case	_	_
19	in	in	FW	FW	_	23	amod	_	_
20	vitro	vitro	FW	FW	_	19	dep	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	11	nmod	_	_
24	after	after	IN	IN	_	27	case	_	_
25	antigen	antigen	NN	NN	_	27	compound	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	triggering	triggering	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	dep	_	_
2	selective	selective	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	13	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	regulation	regulation	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	IL-12R	il-12r	NN	NN	_	11	compound	_	_
9	beta	beta	NN	NN	_	11	compound	_	_
10	2	2	CD	CD	_	11	nummod	_	_
11	subunit	subunit	NN	NN	_	3	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	help	help	VB	VB	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	understand	understand	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	basis	basis	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	Th1/Th2	th1/th2	NN	NN	_	20	compound	_	_
20	differentiation	differentiation	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	provide	provide	VB	VB	_	13	conj	_	_
24	therapeutic	therapeutic	JJ	JJ	_	25	amod	_	_
25	options	option	NNS	NNS	_	23	dobj	_	_
26	for	for	IN	IN	_	27	mark	_	_
27	altering	alter	VBG	VBG	_	25	acl	_	_
28	the	the	DT	DT	_	30	det	_	_
29	Th1/Th2	th1/th2	NN	NN	_	30	compound	_	_
30	balance	balance	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	several	several	JJ	JJ	_	34	amod	_	_
33	immuno-pathological	immuno-pathological	JJ	JJ	_	34	amod	_	_
34	conditions	condition	NNS	NNS	_	27	nmod	_	_
35	such	such	JJ	JJ	_	38	case	_	_
36	as	as	IN	IN	_	35	mwe	_	_
37	autoimmune	autoimmune	JJ	JJ	_	38	amod	_	_
38	diseases	disease	NNS	NNS	_	34	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	allergies	allergy	NNS	NNS	_	38	conj	_	_
41	.	.	.	.	_	13	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	5	dep	_	_
7	in	in	IN	IN	_	10	case	_	_
8	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	10	amod	_	_
9	U937	u937	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	course	course	NN	NN	_	13	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	serious	serious	JJ	JJ	_	7	amod	_	_
6	bacterial	bacterial	JJ	JJ	_	5	dep	_	_
7	infections	infection	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	13	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LPS	lps	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	interacts	interact	VBZ	VBZ	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	monocyte/macrophage	monocyte/macrophage	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	resulting	result	VBG	VBG	_	13	xcomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	generation	generation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	inflammatory	inflammatory	JJ	JJ	_	24	amod	_	_
24	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	5	nsubj	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	2	dep	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	crucial	crucial	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	mark	_	_
7	activating	activate	VBG	VBG	_	5	advcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	genes	gene	NNS	NNS	_	9	nmod	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	proinflammatory	proinflammatory	JJ	JJ	_	14	amod	_	_
14	cytokines	cytokine	NNS	NNS	_	12	dobj	_	_
15	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	22	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	22	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	LPS	lps	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	promonocytic	promonocytic	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	9	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	U937	u937	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	followed	follow	VBD	VBD	_	6	ccomp	_	_
23	a	a	DT	DT	_	26	det	_	_
24	rather	rather	RB	RB	_	25	advmod	_	_
25	slow	slow	JJ	JJ	_	26	amod	_	_
26	kinetics	kinetics	NN	NN	_	22	dobj	_	_
27	,	,	,	,	_	22	punct	_	_
28	depending	depend	VBG	VBG	_	31	case	_	_
29	on	on	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	rate	rate	NN	NN	_	22	advcl	_	_
32	of	of	IN	IN	_	35	case	_	_
33	IkappaB-alpha	ikappab-alpha	NN	NN	_	35	compound	_	_
34	inhibitor	inhibitor	NN	NN	_	35	compound	_	_
35	hydrolysis	hydrolysis	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	degradation	degradation	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p105	p105	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p100	p100	NN	NN	_	4	conj	_	_
7	inhibitors	inhibitor	NNS	NNS	_	4	dep	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	under	under	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	conditions	condition	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transduction	transduction	NN	NN	_	3	compound	_	_
3	pathway	pathway	NN	NN	_	11	nsubj	_	_
4	leading	lead	VBG	VBG	_	3	acl	_	_
5	to	to	TO	TO	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	U937	u937	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	involved	involve	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
14	generation	generation	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	reactive	reactive	JJ	JJ	_	18	amod	_	_
17	oxygen	oxygen	NN	NN	_	18	compound	_	_
18	species	species	NNS	NNS	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	ROS	ro	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	11	punct	_	_
23	as	as	IN	IN	_	24	mark	_	_
24	demonstrated	demonstrate	VBN	VBN	_	11	advcl	_	_
25	by	by	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	concomitant	concomitant	JJ	JJ	_	29	amod	_	_
28	inhibitory	inhibitory	JJ	JJ	_	27	dep	_	_
29	effects	effect	NNS	NNS	_	24	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	antioxidants	antioxidant	NNS	NNS	_	29	nmod	_	_
32	on	on	IN	IN	_	34	case	_	_
33	NF-kappaB	nf-kappab	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	29	nmod	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	the	the	DT	DT	_	37	det	_	_
37	emission	emission	NN	NN	_	29	conj	_	_
38	of	of	IN	IN	_	41	case	_	_
39	a	a	DT	DT	_	41	det	_	_
40	fluorescent	fluorescent	JJ	JJ	_	41	amod	_	_
41	probe	probe	NN	NN	_	37	nmod	_	_
42	reacting	react	VBG	VBG	_	41	acl	_	_
43	intracellularly	intracellularly	RB	RB	_	42	advmod	_	_
44	with	with	IN	IN	_	46	case	_	_
45	hydrogen	hydrogen	NN	NN	_	46	compound	_	_
46	peroxide	peroxide	NN	NN	_	42	nmod	_	_
47	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	ROS	ro	NNS	NNS	_	3	compound	_	_
3	pathway	pathway	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	characterized	characterize	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	use	use	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	other	other	JJ	JJ	_	12	amod	_	_
12	inhibitors	inhibitor	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	phospholipase	phospholipase	NN	NN	_	6	compound	_	_
6	A2	a2	NN	NN	_	11	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	5-lipoxygenase	5-lipoxygenase	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	involved	involve	VBN	VBN	_	3	ccomp	_	_
12	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	pathway	pathway	NN	NN	_	17	nsubj	_	_
7	involving	involve	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	acidic	acidic	JJ	JJ	_	10	amod	_	_
10	sphingomyelinase	sphingomyelinase	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	endolysosomial	endolysosomial	JJ	JJ	_	14	amod	_	_
14	membrane	membrane	NN	NN	_	10	nmod	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	seem	seem	VB	VB	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	participate	participate	VB	VB	_	17	xcomp	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	LPS-induced	lps-induced	JJ	JJ	_	24	amod	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	U937	u937	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	Detection	detection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	adenovirus	adenovirus	NN	NN	_	4	compound	_	_
4	DNA	dna	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
7	blood	blood	NN	NN	_	9	compound	_	_
8	mononuclear	mononuclear	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	by	by	IN	IN	_	14	case	_	_
11	polymerase	polymerase	NN	NN	_	14	compound	_	_
12	chain	chain	NN	NN	_	14	compound	_	_
13	reaction	reaction	NN	NN	_	14	compound	_	_
14	assay	assay	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Adenovirus	adenovirus	NN	NN	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	establish	establish	VB	VB	_	0	root	_	_
4	persistent	persistent	JJ	JJ	_	5	amod	_	_
5	infections	infection	NNS	NNS	_	3	dobj	_	_
6	which	which	WDT	WDT	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	reactivate	reactivate	VB	VB	_	5	acl:relcl	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	cause	cause	VB	VB	_	8	conj	_	_
11	disease	disease	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	immunocompromised	immunocompromised	JJ	JJ	_	14	amod	_	_
14	hosts	host	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	postulated	postulate	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	serve	serve	VB	VB	_	4	xcomp	_	_
7	as	as	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	site	site	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	adenoviral	adenoviral	JJ	JJ	_	12	amod	_	_
12	persistence	persistence	NN	NN	_	9	nmod	_	_
13	based	base	VBN	VBN	_	16	case	_	_
14	upon	upon	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	ability	ability	NN	NN	_	6	advcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	isolate	isolate	VB	VB	_	16	dep	_	_
19	adenovirus	adenovirus	NN	NN	_	18	dobj	_	_
20	from	from	IN	IN	_	21	case	_	_
21	tonsils	tonsil	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	detect	detect	VB	VB	_	18	conj	_	_
25	adenovirus	adenovirus	NN	NN	_	26	compound	_	_
26	DNA	dna	NN	NN	_	24	dobj	_	_
27	by	by	IN	IN	_	30	case	_	_
28	Southern	southern	NN	NN	_	30	compound	_	_
29	blot	blot	NN	NN	_	30	compound	_	_
30	hybridization	hybridization	NN	NN	_	18	nmod	_	_
31	in	in	IN	IN	_	35	case	_	_
32	peripheral	peripheral	JJ	JJ	_	35	amod	_	_
33	blood	blood	NN	NN	_	35	compound	_	_
34	mononuclear	mononuclear	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	18	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	PBMC	pbmc	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	a	a	DT	DT	_	13	det	_	_
7	more	more	RBR	RBR	_	8	advmod	_	_
8	sensitive	sensitive	JJ	JJ	_	13	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	specific	specific	JJ	JJ	_	8	conj	_	_
11	polymerase	polymerase	NN	NN	_	13	compound	_	_
12	chain	chain	NN	NN	_	13	compound	_	_
13	reaction	reaction	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PCR	pcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	assay	assay	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	developed	develop	VBN	VBN	_	2	parataxis	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	detect	detect	VB	VB	_	19	xcomp	_	_
22	adenovirus	adenovirus	NN	NN	_	23	compound	_	_
23	DNA	dna	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	sets	set	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nested	nest	VBD	VBD	_	5	amod	_	_
5	primers	primer	NNS	NNS	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	designed	design	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	conserved	conserve	VBN	VBN	_	10	amod	_	_
10	sequences	sequence	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	adenovirus	adenovirus	NN	NN	_	10	nmod	_	_
14	E1A	e1a	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	hexon	hexon	NN	NN	_	13	conj	_	_
17	genes	gene	NNS	NNS	_	13	dep	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	E1A	e1a	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	hexon	hexon	NN	NN	_	2	conj	_	_
5	primers	primer	NNS	NNS	_	2	dep	_	_
6	amplified	amplify	VBD	VBD	_	0	root	_	_
7	DNA	dna	NN	NN	_	6	dobj	_	_
8	from	from	IN	IN	_	11	case	_	_
9	representative	representative	JJ	JJ	_	11	amod	_	_
10	adenoviral	adenoviral	JJ	JJ	_	9	dep	_	_
11	serotypes	serotype	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	all	all	DT	DT	_	16	det	_	_
14	six	six	CD	CD	_	16	nummod	_	_
15	adenoviral	adenoviral	JJ	JJ	_	16	amod	_	_
16	groups	group	NNS	NNS	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	A-F	a-f	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	6	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	primers	primer	NNS	NNS	_	3	nsubj	_	_
3	detected	detect	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	single	single	JJ	JJ	_	6	amod	_	_
6	copy	copy	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	adenovirus	adenovirus	NN	NN	_	12	compound	_	_
10	type	type	NN	NN	_	12	compound	_	_
11	2	2	CD	CD	_	12	nummod	_	_
12	genome	genome	NN	NN	_	6	nmod	_	_
13	but	but	CC	CC	_	3	cc	_	_
14	were	be	VBD	VBD	_	16	cop	_	_
15	less	less	RBR	RBR	_	16	advmod	_	_
16	sensitive	sensitive	JJ	JJ	_	3	conj	_	_
17	for	for	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	group	group	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	type	type	NN	NN	_	16	nmod	_	_
22	35	35	CD	CD	_	21	nummod	_	_
23	.	.	.	.	_	3	punct	_	_

1	None	none	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	33	33	CD	CD	_	5	nummod	_	_
4	PBMC	pbmc	NN	NN	_	5	compound	_	_
5	specimens	specimen	NNS	NNS	_	1	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	healthy	healthy	JJ	JJ	_	8	amod	_	_
8	adults	adult	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	1	cc	_	_
10	only	only	RB	RB	_	11	advmod	_	_
11	one	one	CD	CD	_	1	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	40	40	CD	CD	_	15	nummod	_	_
14	pediatric	pediatric	JJ	JJ	_	15	amod	_	_
15	samples	sample	NNS	NNS	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	positive	positive	JJ	JJ	_	0	root	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	at	at	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	low	low	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	17	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	for	for	IN	IN	_	26	case	_	_
25	adenovirus	adenovirus	NN	NN	_	26	compound	_	_
26	DNA	dna	NN	NN	_	17	nmod	_	_
27	by	by	IN	IN	_	30	case	_	_
28	nested	nested	JJ	JJ	_	30	amod	_	_
29	PCR	pcr	NN	NN	_	30	compound	_	_
30	assay	assay	NN	NN	_	17	nmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	PBMC	pbmc	NN	NN	_	15	nsubj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	children	child	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	fatal	fatal	JJ	JJ	_	11	amod	_	_
10	adenoviral	adenoviral	JJ	JJ	_	9	dep	_	_
11	infection	infection	NN	NN	_	7	nmod	_	_
12	were	be	VBD	VBD	_	15	cop	_	_
13	both	both	RB	RB	_	15	advmod	_	_
14	strongly	strongly	RB	RB	_	15	advmod	_	_
15	positive	positive	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	adenovirus	adenovirus	NN	NN	_	18	compound	_	_
18	DNA	dna	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	,	,	,	,	_	18	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	contrast	contrast	NN	NN	_	18	nmod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	previous	previous	JJ	JJ	_	11	amod	_	_
11	study	study	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	18	punct	_	_
13	PBMC	pbmc	NN	NN	_	18	nsubj	_	_
14	are	be	VBP	VBP	_	18	cop	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	a	a	DT	DT	_	18	det	_	_
17	common	common	JJ	JJ	_	18	amod	_	_
18	site	site	NN	NN	_	3	ccomp	_	_
19	of	of	IN	IN	_	24	case	_	_
20	persistent	persistent	JJ	JJ	_	24	amod	_	_
21	group	group	NN	NN	_	24	compound	_	_
22	C	c	NN	NN	_	24	compound	_	_
23	adenoviral	adenoviral	JJ	JJ	_	24	amod	_	_
24	infection	infection	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	assay	assay	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	PBMC	pbmc	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	adenovirus-specific	adenovirus-specific	JJ	JJ	_	10	amod	_	_
10	PCR	pcr	NN	NN	_	4	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	help	help	VB	VB	_	0	root	_	_
13	detect	detect	VB	VB	_	12	ccomp	_	_
14	early	early	JJ	JJ	_	16	amod	_	_
15	invasive	invasive	JJ	JJ	_	14	dep	_	_
16	disease	disease	NN	NN	_	13	dobj	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	warrants	warrant	VBZ	VBZ	_	13	conj	_	_
19	further	further	JJ	JJ	_	20	amod	_	_
20	evaluation	evaluation	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	12	punct	_	_

1	Control	control	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NFATx1	nfatx1	NN	NN	_	5	compound	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	translocation	translocation	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	calcineurin-regulated	calcineurin-regulated	JJ	JJ	_	10	amod	_	_
9	inhibitory	inhibitory	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
3	factor	factor	NN	NN	_	7	compound	_	_
4	of	of	IN	IN	_	7	amod	_	_
5	activated	activate	VBN	VBN	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	11	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NFAT	nfat	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	regulates	regulate	VBZ	VBZ	_	0	root	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	through	through	IN	IN	_	20	case	_	_
19	cis-acting	cis-acting	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	11	nmod	_	_
21	located	located	JJ	JJ	_	20	amod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	promoters	promoter	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	several	several	JJ	JJ	_	28	amod	_	_
27	cytokine	cytokine	NN	NN	_	28	compound	_	_
28	genes	gene	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	NFATx1	nfatx1	NN	NN	_	16	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	preferentially	preferentially	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	1	acl:relcl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	thymus	thymus	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	leukocytes	leukocyte	NNS	NNS	_	9	conj	_	_
14	,	,	,	,	_	1	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	one	one	CD	CD	_	0	root	_	_
17	of	of	IN	IN	_	19	case	_	_
18	four	four	CD	CD	_	19	nummod	_	_
19	members	member	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	NFAT	nfat	NN	NN	_	23	compound	_	_
23	family	family	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	performed	perform	VBN	VBN	_	0	root	_	_
4	domain	domain	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NFATx1	nfatx1	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	examining	examine	VBG	VBG	_	3	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	deletion	deletion	NN	NN	_	14	compound	_	_
14	mutations	mutation	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	NFATx1	nfatx1	NN	NN	_	14	nsubj	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	dep	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	interaction	interaction	NN	NN	_	4	conj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	AP-1	ap-1	NN	NN	_	12	compound	_	_
12	polypeptides	polypeptide	NNS	NNS	_	9	nmod	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	dependent	dependent	JJ	JJ	_	2	ccomp	_	_
15	on	on	IN	IN	_	20	case	_	_
16	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
17	central	central	JJ	JJ	_	20	amod	_	_
18	Rel	rel	NN	NN	_	20	compound	_	_
19	similarity	similarity	NN	NN	_	20	compound	_	_
20	region	region	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	reduced	reduce	VBN	VBN	_	14	conj	_	_
27	by	by	IN	IN	_	28	case	_	_
28	deletions	deletion	NNS	NNS	_	26	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	either	either	CC	CC	_	33	cc:preconj	_	_
31	its	its	PRP$	PRP$	_	33	nmod:poss	_	_
32	N-terminal	n-terminal	JJ	JJ	_	33	amod	_	_
33	domain	domain	NN	NN	_	28	nmod	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	its	its	PRP$	PRP$	_	37	nmod:poss	_	_
36	C-terminal	c-terminal	JJ	JJ	_	37	amod	_	_
37	domain	domain	NN	NN	_	33	conj	_	_
38	,	,	,	,	_	2	punct	_	_
39	suggesting	suggest	VBG	VBG	_	2	xcomp	_	_
40	the	the	DT	DT	_	41	det	_	_
41	presence	presence	NN	NN	_	39	dobj	_	_
42	of	of	IN	IN	_	46	case	_	_
43	intrinsic	intrinsic	JJ	JJ	_	46	amod	_	_
44	transcriptional	transcriptional	JJ	JJ	_	46	amod	_	_
45	activation	activation	NN	NN	_	46	compound	_	_
46	motifs	motif	NNS	NNS	_	41	nmod	_	_
47	in	in	IN	IN	_	49	case	_	_
48	both	both	DT	DT	_	49	det	_	_
49	regions	region	NNS	NNS	_	41	nmod	_	_
50	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	potent	potent	JJ	JJ	_	7	amod	_	_
6	inhibitory	inhibitory	JJ	JJ	_	7	amod	_	_
7	sequence	sequence	NN	NN	_	3	dobj	_	_
8	within	within	IN	IN	_	11	case	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	inactivation	inactivation	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	inhibition	inhibition	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	2	ccomp	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	calcineurin	calcineurin	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	19	det	_	_
18	calcium-calmodulin-dependent	calcium-calmodulin-dependent	JJ	JJ	_	19	amod	_	_
19	phosphatase	phosphatase	NN	NN	_	15	appos	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	calcineurin	calcineurin	NN	NN	_	6	nsubj	_	_
6	associated	associate	VBD	VBD	_	3	ccomp	_	_
7	with	with	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	N-terminal	n-terminal	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NFATx1	nfatx1	NN	NN	_	10	nmod	_	_
13	at	at	IN	IN	_	16	case	_	_
14	multiple	multiple	JJ	JJ	_	16	amod	_	_
15	docking	docking	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	6	nmod	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	caused	cause	VBD	VBD	_	6	conj	_	_
19	a	a	DT	DT	_	20	det	_	_
20	reduction	reduction	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	size	size	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	20	punct	_	_
24	indicative	indicative	JJ	JJ	_	20	amod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	dephosphorylation	dephosphorylation	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	in	in	IN	IN	_	29	case	_	_
29	NFATx1	nfatx1	NN	NN	_	20	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	mapped	map	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	inhibitory	inhibitory	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	less	less	JJR	JJR	_	3	nmod	_	_
9	than	than	IN	IN	_	8	amod	_	_
10	60	60	CD	CD	_	11	nummod	_	_
11	residues	residue	NNS	NNS	_	8	dep	_	_
12	,	,	,	,	_	8	punct	_	_
13	containing	contain	VBG	VBG	_	8	acl	_	_
14	motifs	motif	NNS	NNS	_	13	dobj	_	_
15	that	that	WDT	WDT	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	conserved	conserve	VBN	VBN	_	14	acl:relcl	_	_
18	in	in	IN	IN	_	21	case	_	_
19	all	all	DT	DT	_	21	det	_	_
20	NFAT	nfat	NN	NN	_	21	compound	_	_
21	proteins	protein	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	deletion	deletion	NN	NN	_	14	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	NFATx1	nfatx1	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	mapped	map	VBN	VBN	_	13	amod	_	_
12	60	60	CD	CD	_	13	nummod	_	_
13	residues	residue	NNS	NNS	_	6	nmod	_	_
14	leads	lead	VBZ	VBZ	_	4	ccomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	translocation	translocation	NN	NN	_	14	nmod	_	_
19	independent	independent	JJ	JJ	_	18	amod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	calcium	calcium	NN	NN	_	22	compound	_	_
22	signaling	signaling	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	proposing	propose	VBG	VBG	_	5	acl	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	N-terminal	n-terminal	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	11	nsubj	_	_
11	confers	confer	VBZ	VBZ	_	6	ccomp	_	_
12	calcium-signaling	calcium-signaling	JJ	JJ	_	13	amod	_	_
13	dependence	dependence	NN	NN	_	11	dobj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	NFATx1	nfatx1	NN	NN	_	17	compound	_	_
16	transactivation	transactivation	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	regulating	regulate	VBG	VBG	_	11	advcl	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	intracellular	intracellular	JJ	JJ	_	22	amod	_	_
22	localization	localization	NN	NN	_	19	dobj	_	_
23	through	through	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	module	module	NN	NN	_	19	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	associates	associate	VBZ	VBZ	_	26	acl:relcl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	calcineurin	calcineurin	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	is	be	VBZ	VBZ	_	34	cop	_	_
33	a	a	DT	DT	_	34	det	_	_
34	target	target	NN	NN	_	28	conj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	its	its	PRP$	PRP$	_	38	nmod:poss	_	_
37	phosphatase	phosphatase	NN	NN	_	38	compound	_	_
38	activity	activity	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	PMLRARalpha	pmlraralpha	NN	NN	_	3	compound	_	_
3	transgene	transgene	NN	NN	_	4	nsubj	_	_
4	initiates	initiate	VBZ	VBZ	_	0	root	_	_
5	murine	murine	JJ	JJ	_	8	amod	_	_
6	acute	acute	JJ	JJ	_	8	amod	_	_
7	promyelocytic	promyelocytic	JJ	JJ	_	8	amod	_	_
8	leukemia	leukemia	NN	NN	_	4	dobj	_	_
9	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	malignant	malignant	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	acute	acute	JJ	JJ	_	7	amod	_	_
6	promyelocytic	promyelocytic	JJ	JJ	_	7	amod	_	_
7	leukemia	leukemia	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	APL	apl	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	contain	contain	VBP	VBP	_	0	root	_	_
12	a	a	DT	DT	_	15	det	_	_
13	reciprocal	reciprocal	JJ	JJ	_	15	amod	_	_
14	chromosomal	chromosomal	JJ	JJ	_	13	dep	_	_
15	translocation	translocation	NN	NN	_	11	dobj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	fuses	fuse	VBZ	VBZ	_	15	acl:relcl	_	_
18	the	the	DT	DT	_	21	det	_	_
19	promyelocytic	promyelocytic	JJ	JJ	_	21	amod	_	_
20	leukemia	leukemia	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	dobj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PML	pml	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	with	with	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	det	_	_
27	retinoic	retinoic	JJ	JJ	_	31	amod	_	_
28	acid	acid	NN	NN	_	31	compound	_	_
29	receptor	receptor	NN	NN	_	31	compound	_	_
30	alpha	alpha	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	17	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	RAR	rar	NN	NN	_	34	compound	_	_
34	alpha	alpha	NN	NN	_	31	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	chimera	chimera	NN	NN	_	9	compound	_	_
8	PMLRAR	pmlrar	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	4	ccomp	_	_
11	a	a	DT	DT	_	12	det	_	_
12	role	role	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	leukemogenesis	leukemogenesis	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	expressed	express	VBD	VBD	_	2	parataxis	_	_
18	a	a	DT	DT	_	21	det	_	_
19	PMLRAR	pmlrar	NN	NN	_	21	compound	_	_
20	alpha	alpha	NN	NN	_	21	compound	_	_
21	cDNA	cdna	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	17	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	transgenic	transgenic	JJ	JJ	_	27	amod	_	_
27	mice	mouse	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	PMLRAR	pmlrar	NN	NN	_	4	compound	_	_
2	alpha	alpha	NN	NN	_	4	compound	_	_
3	transgenic	transgenic	JJ	JJ	_	4	amod	_	_
4	mice	mouse	NNS	NNS	_	5	nsubj	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	impaired	impaired	JJ	JJ	_	8	amod	_	_
7	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
8	maturation	maturation	NN	NN	_	5	dobj	_	_
9	early	early	RB	RB	_	11	advmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	life	life	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	progressed	progress	VBD	VBD	_	8	acl:relcl	_	_
15	at	at	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	low	low	JJ	JJ	_	18	amod	_	_
18	frequency	frequency	NN	NN	_	14	nmod	_	_
19	over	over	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	course	course	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	several	several	JJ	JJ	_	24	amod	_	_
24	months	month	NNS	NNS	_	21	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	overt	overt	JJ	JJ	_	27	amod	_	_
27	APL	apl	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Both	both	CC	CC	_	4	cc:preconj	_	_
2	the	the	DT	DT	_	4	det	_	_
3	preleukemic	preleukemic	JJ	JJ	_	4	amod	_	_
4	state	state	NN	NN	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	leukemia	leukemia	NN	NN	_	4	conj	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	transplanted	transplant	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	nontransgenic	nontransgenic	JJ	JJ	_	13	amod	_	_
13	mice	mouse	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transplanted	transplant	VBN	VBN	_	18	amod	_	_
18	preleukemia	preleukemia	NN	NN	_	20	nsubj	_	_
19	could	could	MD	MD	_	20	aux	_	_
20	progress	progress	VB	VB	_	10	conj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	APL	apl	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	APL	apl	NN	NN	_	3	nsubj	_	_
3	recapitulated	recapitulate	VBD	VBD	_	0	root	_	_
4	features	feature	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	disease	disease	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	including	include	VBG	VBG	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	response	response	NN	NN	_	4	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	retinoic	retinoic	JJ	JJ	_	15	amod	_	_
15	acid	acid	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	caused	cause	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	leukemic	leukemic	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	differentiate	differentiate	VB	VB	_	3	xcomp	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	11	advmod	_	_
11	and	and	CC	CC	_	8	advmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	11	advmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	eliciting	elicit	VBG	VBG	_	3	xcomp	_	_
16	remissions	remission	NNS	NNS	_	15	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	both	both	CC	CC	_	21	cc:preconj	_	_
19	the	the	DT	DT	_	21	det	_	_
20	preleukemic	preleukemic	JJ	JJ	_	21	amod	_	_
21	state	state	NN	NN	_	16	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	APL	apl	NN	NN	_	21	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	mice	mouse	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PMLRAR	pmlrar	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	7	nsubj	_	_
7	impairs	impair	VBZ	VBZ	_	3	ccomp	_	_
8	neutrophil	neutrophil	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	initiates	initiate	VBZ	VBZ	_	7	conj	_	_
12	the	the	DT	DT	_	13	det	_	_
13	development	development	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	APL	apl	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transgenic	transgenic	JJ	JJ	_	3	amod	_	_
3	mice	mouse	NNS	NNS	_	6	nsubj	_	_
4	described	describe	VBN	VBN	_	3	acl	_	_
5	here	here	RB	RB	_	4	advmod	_	_
6	provide	provide	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	10	det	_	_
8	apparently	apparently	RB	RB	_	9	advmod	_	_
9	accurate	accurate	JJ	JJ	_	10	amod	_	_
10	model	model	NN	NN	_	6	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	APL	apl	NN	NN	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	includes	include	VBZ	VBZ	_	10	acl:relcl	_	_
16	clear	clear	JJ	JJ	_	17	amod	_	_
17	evidence	evidence	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	tumor	tumor	NN	NN	_	20	compound	_	_
20	progression	progression	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	model	model	NN	NN	_	5	nsubj	_	_
3	should	should	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	cop	_	_
5	useful	useful	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	mark	_	_
7	exploring	explore	VBG	VBG	_	5	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	pathogenesis	pathogenesis	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	APL	apl	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mechanisms	mechanism	NNS	NNS	_	10	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	therapeutic	therapeutic	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	15	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	retinoic	retinoic	JJ	JJ	_	22	amod	_	_
22	acid	acid	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	7	punct	_	_
24	as	as	RB	RB	_	7	cc	_	_
25	well	well	RB	RB	_	24	mwe	_	_
26	as	as	IN	IN	_	24	mwe	_	_
27	for	for	IN	IN	_	29	case	_	_
28	preclinical	preclinical	JJ	JJ	_	29	amod	_	_
29	studies	study	NNS	NNS	_	7	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	therapeutic	therapeutic	JJ	JJ	_	32	amod	_	_
32	regimens	regimen	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	transducer	transducer	NN	NN	_	12	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activator	activator	NN	NN	_	6	compound	_	_
5	of	of	IN	IN	_	6	amod	_	_
6	transcription-3	transcription-3	NN	NN	_	2	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	STAT3	stat3	NN	NN	_	2	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	constitutively	constitutively	RB	RB	_	12	advmod	_	_
12	activated	activate	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	18	case	_	_
14	normal	normal	JJ	JJ	_	18	amod	_	_
15	,	,	,	,	_	18	punct	_	_
16	self-renewing	self-renewing	JJ	JJ	_	18	amod	_	_
17	B-1	b-1	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	but	but	CC	CC	_	12	cc	_	_
20	only	only	RB	RB	_	21	advmod	_	_
21	inducibly	inducibly	RB	RB	_	22	advmod	_	_
22	expressed	express	VBN	VBN	_	12	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	conventional	conventional	JJ	JJ	_	26	amod	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	22	nmod	_	_
27	-LSB-	-lsb-	-LRB-	-LRB-	_	28	punct	_	_
28	see	see	VB	VB	_	12	parataxis	_	_
29	comments	comment	NNS	NNS	_	28	dobj	_	_
30	-RSB-	-rsb-	-RRB-	-RRB-	_	28	punct	_	_

1	Cytokine	cytokine	NN	NN	_	6	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	growth	growth	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	1	conj	_	_
6	engagement	engagement	NN	NN	_	7	nsubj	_	_
7	leads	lead	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	dep	_	_
10	rapid	rapid	JJ	JJ	_	11	amod	_	_
11	phosphorylation	phosphorylation	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	activation	activation	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	latent	latent	JJ	JJ	_	19	amod	_	_
16	,	,	,	,	_	19	punct	_	_
17	cytosolic	cytosolic	JJ	JJ	_	19	amod	_	_
18	signal	signal	NN	NN	_	19	compound	_	_
19	transducers	transducer	NNS	NNS	_	11	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	activators	activator	NNS	NNS	_	27	compound	_	_
22	of	of	IN	IN	_	27	amod	_	_
23	transcription	transcription	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	27	punct	_	_
25	STAT	stat	NN	NN	_	27	compound	_	_
26	)	)	-RRB-	-RRB-	_	27	punct	_	_
27	proteins	protein	NNS	NNS	_	19	conj	_	_
28	,	,	,	,	_	11	punct	_	_
29	which	which	WDT	WDT	_	31	nsubj	_	_
30	then	then	RB	RB	_	31	advmod	_	_
31	translocate	translocate	VBP	VBP	_	11	acl:relcl	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	nucleus	nucleus	NN	NN	_	31	nmod	_	_
35	where	where	WRB	WRB	_	37	advmod	_	_
36	they	they	PRP	PRP	_	37	nsubj	_	_
37	regulate	regulate	VBP	VBP	_	34	acl:relcl	_	_
38	transcriptional	transcriptional	JJ	JJ	_	39	amod	_	_
39	events	event	NNS	NNS	_	37	dobj	_	_
40	from	from	IN	IN	_	43	case	_	_
41	specific	specific	JJ	JJ	_	43	amod	_	_
42	promoter	promoter	NN	NN	_	43	compound	_	_
43	sequences	sequence	NNS	NNS	_	39	nmod	_	_
44	.	.	.	.	_	7	punct	_	_

1	STAT3	stat3	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	particular	particular	JJ	JJ	_	7	nmod	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	15	case	_	_
9	Abl	abl	NN	NN	_	15	compound	_	_
10	,	,	,	,	_	9	punct	_	_
11	Src	src	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	HTLV-1	htlv-1	NN	NN	_	9	conj	_	_
15	transformation	transformation	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	B-1	b-1	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubj	_	_
3	are	be	VBP	VBP	_	8	cop	_	_
4	self-renewing	self-renewing	JJ	JJ	_	8	amod	_	_
5	,	,	,	,	_	8	punct	_	_
6	CD5+	cd5+	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	0	root	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	display	display	VBP	VBP	_	8	acl:relcl	_	_
11	a	a	DT	DT	_	12	det	_	_
12	propensity	propensity	NN	NN	_	10	dobj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	malignant	malignant	JJ	JJ	_	15	amod	_	_
15	transformation	transformation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	are	be	VBP	VBP	_	20	cop	_	_
18	the	the	DT	DT	_	20	det	_	_
19	normal	normal	JJ	JJ	_	20	amod	_	_
20	counterpart	counterpart	NN	NN	_	10	conj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	chronic	chronic	JJ	JJ	_	25	amod	_	_
24	lymphocytic	lymphocytic	JJ	JJ	_	25	amod	_	_
25	leukemias	leukemia	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Further	further	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	B-1	b-1	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	characterized	characterize	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	aberrant	aberrant	JJ	JJ	_	10	amod	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	signaling	signaling	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	including	include	VBG	VBG	_	13	case	_	_
13	hyperresponsiveness	hyperresponsiveness	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	phorbol	phorbol	NN	NN	_	18	compound	_	_
16	ester	ester	NN	NN	_	18	compound	_	_
17	PKC	pkc	NN	NN	_	18	compound	_	_
18	agonists	agonist	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	B-1	b-1	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubj	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	express	express	VBP	VBP	_	3	ccomp	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	activated	activate	VBN	VBN	_	11	amod	_	_
11	STAT3	stat3	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	16	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	expressed	express	VBN	VBN	_	11	acl:relcl	_	_
17	by	by	IN	IN	_	23	case	_	_
18	unmanipulated	unmanipulated	JJ	JJ	_	23	amod	_	_
19	conventional	conventional	JJ	JJ	_	23	amod	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	B-2	b-2	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	STAT3	stat3	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B-2	b-2	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	after	after	IN	IN	_	14	case	_	_
12	antigen	antigen	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	engagement	engagement	NN	NN	_	7	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	delayed	delayed	JJ	JJ	_	18	amod	_	_
18	fashion	fashion	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	after	after	IN	IN	_	22	case	_	_
21	3	3	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	18	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	7	punct	_	_

1	Induction	induction	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	STAT3	stat3	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	12	case	_	_
7	both	both	CC	CC	_	12	cc:preconj	_	_
8	the	the	DT	DT	_	12	det	_	_
9	serine/threonine	serine/threonine	NN	NN	_	12	compound	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	inhibitor	inhibitor	NN	NN	_	5	nmod	_	_
13	H-7	h-7	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	immunosuppressive	immunosuppressive	JJ	JJ	_	17	amod	_	_
17	drug	drug	NN	NN	_	12	conj	_	_
18	rapamycin	rapamycin	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	requires	require	VBZ	VBZ	_	5	conj	_	_
21	de	de	FW	FW	_	24	amod	_	_
22	novo	novo	FW	FW	_	21	dep	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	synthesis	synthesis	NN	NN	_	20	dobj	_	_
25	,	,	,	,	_	20	punct	_	_
26	demonstrating	demonstrate	VBG	VBG	_	20	advcl	_	_
27	novel	novel	JJ	JJ	_	28	amod	_	_
28	coupling	coupling	NN	NN	_	26	dobj	_	_
29	between	between	IN	IN	_	30	case	_	_
30	sIg	sig	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	STAT	stat	NN	NN	_	33	compound	_	_
33	proteins	protein	NNS	NNS	_	30	conj	_	_
34	that	that	WDT	WDT	_	35	nsubj	_	_
35	differs	differ	VBZ	VBZ	_	28	acl:relcl	_	_
36	from	from	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	classical	classical	JJ	JJ	_	39	amod	_	_
39	paradigm	paradigm	NN	NN	_	35	nmod	_	_
40	for	for	IN	IN	_	42	case	_	_
41	STAT	stat	NN	NN	_	42	compound	_	_
42	induction	induction	NN	NN	_	39	nmod	_	_
43	by	by	IN	IN	_	45	case	_	_
44	cytokine	cytokine	NN	NN	_	45	compound	_	_
45	receptors	receptor	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inability	inability	NN	NN	_	27	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	prolonged	prolonged	JJ	JJ	_	5	amod	_	_
5	stimulation	stimulation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	conventional	conventional	JJ	JJ	_	9	amod	_	_
8	B-2	b-2	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	anti-Ig	anti-ig	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	treatment	treatment	NN	NN	_	5	appos	_	_
15	sufficient	sufficient	JJ	JJ	_	14	amod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	15	dep	_	_
18	CD5	cd5	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	,	,	,	,	_	17	punct	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	result	result	VB	VB	_	17	dep	_	_
23	in	in	IN	IN	_	26	case	_	_
24	sustained	sustained	JJ	JJ	_	26	amod	_	_
25	STAT3	stat3	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	suggests	suggest	VBZ	VBZ	_	0	root	_	_
28	that	that	IN	IN	_	34	mark	_	_
29	STAT3	stat3	NN	NN	_	34	nsubj	_	_
30	is	be	VBZ	VBZ	_	34	cop	_	_
31	a	a	DT	DT	_	34	det	_	_
32	specific	specific	JJ	JJ	_	34	amod	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	marker	marker	NN	NN	_	27	ccomp	_	_
35	for	for	IN	IN	_	37	case	_	_
36	B-1	b-1	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	27	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	STAT3	stat3	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	play	play	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	13	case	_	_
9	B	b	NN	NN	_	13	compound	_	_
10	cell	cell	NN	NN	_	13	compound	_	_
11	antigen-specific	antigen-specific	JJ	JJ	_	13	amod	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	responses	response	NNS	NNS	_	5	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	constitutive	constitutive	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	associated	associate	VBN	VBN	_	5	conj	_	_
21	with	with	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	normal	normal	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	population	population	NN	NN	_	20	nmod	_	_
26	exhibiting	exhibit	VBG	VBG	_	25	acl	_	_
27	intrinsic	intrinsic	JJ	JJ	_	29	amod	_	_
28	proliferative	proliferative	JJ	JJ	_	29	amod	_	_
29	behavior	behavior	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	T	t	NN	NN	_	5	compound	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	activation	activation	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	8	nsubj	_	_
6	NF-ATc	nf-atc	NN	NN	_	5	dep	_	_
7	positively	positively	RB	RB	_	8	advmod	_	_
8	regulates	regulate	VBZ	VBZ	_	0	root	_	_
9	HIV-1	hiv-1	NN	NN	_	8	dobj	_	_
10	replication	replication	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Clinical	clinical	JJ	JJ	_	2	amod	_	_
2	deterioration	deterioration	NN	NN	_	14	nsubjpass	_	_
3	in	in	IN	IN	_	12	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	12	compound	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HIV-1	hiv-1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	infection	infection	NN	NN	_	2	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	17	case	_	_
16	increased	increase	VBN	VBN	_	17	amod	_	_
17	levels	level	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	replication	replication	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	burden	burden	NN	NN	_	17	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	dep	_	_
25	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
26	blood	blood	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	lymphoid	lymphoid	JJ	JJ	_	29	amod	_	_
29	organs	organ	NNS	NNS	_	26	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	11	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	ensuing	ensuing	JJ	JJ	_	8	amod	_	_
6	cellular	cellular	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	3	conj	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	critical	critical	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	replication	replication	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	hypothesis	hypothesis	NN	NN	_	20	nsubj	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	the	the	DT	DT	_	10	det	_	_
5	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
6	factor	factor	NN	NN	_	10	compound	_	_
7	of	of	IN	IN	_	10	amod	_	_
8	activated	activate	VBN	VBN	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	15	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	NF-AT	nf-at	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	influence	influence	VB	VB	_	2	ccomp	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	replication	replication	NN	NN	_	15	dobj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	therefore	therefore	RB	RB	_	20	advmod	_	_
20	compelling	compelling	JJ	JJ	_	0	root	_	_
21	given	give	VBN	VBN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	tight	tight	JJ	JJ	_	24	amod	_	_
24	correlation	correlation	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	HIV-1	hiv-1	NN	NN	_	28	compound	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	induction	induction	NN	NN	_	24	nmod	_	_
29	to	to	TO	TO	_	32	case	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	certain	certain	JJ	JJ	_	10	amod	_	_
5	NF-AT	nf-at	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	Rel	rel	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	members	member	NNS	NNS	_	12	nsubj	_	_
11	productively	productively	RB	RB	_	12	advmod	_	_
12	bind	bind	VBP	VBP	_	2	ccomp	_	_
13	the	the	DT	DT	_	16	det	_	_
14	kappaB	kappab	NN	NN	_	16	compound	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	elements	element	NNS	NNS	_	12	dobj	_	_
17	,	,	,	,	_	12	punct	_	_
18	synergize	synergize	VBP	VBP	_	12	conj	_	_
19	with	with	IN	IN	_	20	case	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Tat	tat	NN	NN	_	20	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	activation	activation	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	HIV-1	hiv-1	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	12	punct	_	_
29	and	and	CC	CC	_	12	cc	_	_
30	enhance	enhance	VBP	VBP	_	12	conj	_	_
31	HIV-1	hiv-1	NN	NN	_	32	compound	_	_
32	replication	replication	NN	NN	_	30	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	link	link	VBP	VBP	_	0	root	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	3	dobj	_	_
6	critical	critical	JJ	JJ	_	5	amod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	commitment	commitment	NN	NN	_	6	nmod	_	_
11	directly	directly	RB	RB	_	3	advmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	replication	replication	NN	NN	_	3	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	ALY	aly	NN	NN	_	12	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	context-dependent	context-dependent	JJ	JJ	_	5	amod	_	_
5	coactivator	coactivator	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	7	case	_	_
7	LEF-1	lef-1	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	AML-1	aml-1	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	1	punct	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	0	root	_	_
13	for	for	IN	IN	_	16	case	_	_
14	TCRalpha	tcralpha	NN	NN	_	15	compound	_	_
15	enhancer	enhancer	NN	NN	_	16	compound	_	_
16	function	function	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	LEF-1	lef-1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	participates	participate	VBZ	VBZ	_	5	acl:relcl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	20	case	_	_
12	the	the	DT	DT	_	20	det	_	_
13	T-cell	t-cell	NN	NN	_	20	compound	_	_
14	receptor	receptor	NN	NN	_	20	compound	_	_
15	alpha	alpha	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	TCR	tcr	NN	NN	_	20	compound	_	_
18	alpha	alpha	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	enhancer	enhancer	NN	NN	_	10	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	facilitating	facilitate	VBG	VBG	_	7	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	assembly	assembly	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	multiple	multiple	JJ	JJ	_	27	amod	_	_
27	proteins	protein	NNS	NNS	_	24	nmod	_	_
28	into	into	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	higher	higher	JJR	JJR	_	31	amod	_	_
31	order	order	NN	NN	_	22	nmod	_	_
32	nucleoprotein	nucleoprotein	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	31	dep	_	_
34	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	LEF-1	lef-1	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	dependent	dependent	JJ	JJ	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	in	in	IN	IN	_	9	case	_	_
9	part	part	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	on	on	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HMG	hmg	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	6	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	induces	induce	VBZ	VBZ	_	14	acl:relcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	sharp	sharp	JJ	JJ	_	19	amod	_	_
19	bend	bend	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	helix	helix	NN	NN	_	16	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	on	on	IN	IN	_	29	case	_	_
27	an	a	DT	DT	_	29	det	_	_
28	activation	activation	NN	NN	_	29	compound	_	_
29	domain	domain	NN	NN	_	14	conj	_	_
30	that	that	WDT	WDT	_	31	nsubj	_	_
31	stimulates	stimulate	VBZ	VBZ	_	29	acl:relcl	_	_
32	transcription	transcription	NN	NN	_	31	dobj	_	_
33	only	only	RB	RB	_	37	advmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	specific	specific	JJ	JJ	_	37	amod	_	_
37	context	context	NN	NN	_	31	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	other	other	JJ	JJ	_	41	amod	_	_
40	enhancer-binding	enhancer-binding	JJ	JJ	_	41	amod	_	_
41	proteins	protein	NNS	NNS	_	37	nmod	_	_
42	.	.	.	.	_	6	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	aim	aim	NN	NN	_	16	nmod	_	_
4	of	of	IN	IN	_	5	mark	_	_
5	gaining	gain	VBG	VBG	_	3	acl	_	_
6	insight	insight	NN	NN	_	5	dobj	_	_
7	into	into	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	function	function	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	context-dependent	context-dependent	JJ	JJ	_	13	amod	_	_
12	activation	activation	NN	NN	_	13	compound	_	_
13	domains	domain	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	cloned	clone	VBD	VBD	_	0	root	_	_
17	ALY	aly	NN	NN	_	16	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	22	det	_	_
20	novel	novel	JJ	JJ	_	22	amod	_	_
21	LEF-1-interacting	lef-1-interacting	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	17	appos	_	_
23	.	.	.	.	_	16	punct	_	_

1	ALY	aly	NN	NN	_	8	nsubj	_	_
2	is	be	VBZ	VBZ	_	8	cop	_	_
3	a	a	DT	DT	_	8	det	_	_
4	ubiquitously	ubiquitously	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	8	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	nuclear	nuclear	JJ	JJ	_	5	dep	_	_
8	protein	protein	NN	NN	_	0	root	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	specifically	specifically	RB	RB	_	11	advmod	_	_
11	associates	associate	VBZ	VBZ	_	8	acl:relcl	_	_
12	with	with	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	activation	activation	NN	NN	_	15	compound	_	_
15	domains	domain	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	LEF-1	lef-1	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	AML-1	aml-1	NN	NN	_	17	conj	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	CBF	cbf	NN	NN	_	22	compound	_	_
22	alpha2	alpha2	NN	NN	_	15	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	PEBP2	pebp2	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	27	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	B	b	NN	NN	_	22	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	8	punct	_	_
30	which	which	WDT	WDT	_	34	nsubj	_	_
31	is	be	VBZ	VBZ	_	34	cop	_	_
32	another	another	DT	DT	_	34	det	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	component	component	NN	NN	_	8	acl:relcl	_	_
35	of	of	IN	IN	_	40	case	_	_
36	the	the	DT	DT	_	40	det	_	_
37	TCR	tcr	NN	NN	_	40	compound	_	_
38	alpha	alpha	NN	NN	_	40	compound	_	_
39	enhancer	enhancer	NN	NN	_	40	compound	_	_
40	complex	complex	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	ALY	aly	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	increase	increase	VB	VB	_	0	root	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	6	dobj	_	_
9	by	by	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	LEF-1	lef-1	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	AML	aml	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	6	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ALY	aly	NN	NN	_	1	nmod	_	_
4	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	TCR	tcr	NN	NN	_	12	compound	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	6	nmod	_	_
13	reconstituted	reconstitute	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	18	case	_	_
15	transfected	transfect	VBN	VBN	_	18	amod	_	_
16	nonlymphoid	nonlymphoid	JJ	JJ	_	18	amod	_	_
17	HeLa	hela	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	whereas	whereas	IN	IN	_	28	mark	_	_
21	down-regulation	down-regulation	NN	NN	_	28	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	ALY	aly	NN	NN	_	21	nmod	_	_
24	by	by	IN	IN	_	26	case	_	_
25	anti-sense	anti-sense	JJ	JJ	_	26	amod	_	_
26	oligonucleotides	oligonucleotide	NNS	NNS	_	21	nmod	_	_
27	virtually	virtually	RB	RB	_	28	advmod	_	_
28	eliminates	eliminate	VBZ	VBZ	_	4	advcl	_	_
29	TCR	tcr	NN	NN	_	31	compound	_	_
30	alpha	alpha	NN	NN	_	31	compound	_	_
31	enhancer	enhancer	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	28	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	Similar	similar	JJ	JJ	_	7	advmod	_	_
2	to	to	TO	TO	_	3	case	_	_
3	LEF-1	lef-1	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	ALY	aly	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	stimulate	stimulate	VB	VB	_	0	root	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	context	context	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	TCR	tcr	NN	NN	_	16	compound	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	enhancer	enhancer	NN	NN	_	11	nmod	_	_
17	but	but	CC	CC	_	21	cc	_	_
18	apparently	apparently	RB	RB	_	21	dep	_	_
19	not	not	RB	RB	_	21	dep	_	_
20	when	when	WRB	WRB	_	21	advmod	_	_
21	tethered	tether	VBN	VBN	_	7	parataxis	_	_
22	to	to	TO	TO	_	23	case	_	_
23	DNA	dna	NN	NN	_	21	nmod	_	_
24	through	through	IN	IN	_	28	case	_	_
25	an	a	DT	DT	_	28	det	_	_
26	heterologous	heterologous	JJ	JJ	_	28	amod	_	_
27	DNA-binding	dna-binding	JJ	JJ	_	28	amod	_	_
28	domain	domain	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	ALY	aly	NN	NN	_	5	nsubj	_	_
5	mediates	mediate	VBZ	VBZ	_	2	ccomp	_	_
6	context-dependent	context-dependent	JJ	JJ	_	8	amod	_	_
7	transcriptional	transcriptional	JJ	JJ	_	6	dep	_	_
8	activation	activation	NN	NN	_	5	dobj	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	facilitating	facilitate	VBG	VBG	_	5	advcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	functional	functional	JJ	JJ	_	13	amod	_	_
13	collaboration	collaboration	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	multiple	multiple	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	TCR	tcr	NN	NN	_	22	compound	_	_
20	alpha	alpha	NN	NN	_	22	compound	_	_
21	enhancer	enhancer	NN	NN	_	22	compound	_	_
22	complex	complex	NN	NN	_	10	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Differentiation	differentiation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T-helper	t-helper	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	:	:	:	:	_	1	punct	_	_
6	selective	selective	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	1	dep	_	_
8	by	by	IN	IN	_	9	case	_	_
9	members	member	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	STAT	stat	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-4	il-4	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	interleukin-12	interleukin-12	NN	NN	_	1	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-12	il-12	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	control	control	VBP	VBP	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	differentiation	differentiation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	T-helper	t-helper	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	summarize	summarize	VBP	VBP	_	0	root	_	_
4	studies	study	NNS	NNS	_	3	dobj	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	investigate	investigate	VBP	VBP	_	4	acl:relcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	6	dobj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	14	nmod	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cytokines	cytokine	NNS	NNS	_	14	nsubj	_	_
13	selectively	selectively	RB	RB	_	14	advmod	_	_
14	reprogramme	reprogramme	VBP	VBP	_	8	acl:relcl	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	T-lymphocytes	t-lymphocyte	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	3	nsubj	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	phosphorylation	phosphorylation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	specific	specific	JJ	JJ	_	10	amod	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	residues	residue	NNS	NNS	_	6	nmod	_	_
11	within	within	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	corresponding	corresponding	JJ	JJ	_	19	amod	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	phosphotyrosines	phosphotyrosine	NNS	NNS	_	3	nsubj	_	_
3	serve	serve	VBP	VBP	_	0	root	_	_
4	as	as	IN	IN	_	6	case	_	_
5	docking	docking	NN	NN	_	6	compound	_	_
6	sites	site	NNS	NNS	_	3	nmod	_	_
7	for	for	IN	IN	_	12	case	_	_
8	latent	latent	JJ	JJ	_	12	amod	_	_
9	,	,	,	,	_	12	punct	_	_
10	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	6	nmod	_	_
13	known	know	VBN	VBN	_	12	acl	_	_
14	as	as	IN	IN	_	16	case	_	_
15	signal	signal	NN	NN	_	16	compound	_	_
16	transducers	transducer	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	activators	activator	NNS	NNS	_	24	compound	_	_
19	of	of	IN	IN	_	24	amod	_	_
20	transcription	transcription	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	Stat	stat	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	proteins	protein	NNS	NNS	_	16	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Receptor/Stat	receptor/stat	NN	NN	_	2	compound	_	_
2	interaction	interaction	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	13	case	_	_
6	the	the	DT	DT	_	13	det	_	_
7	src	src	NN	NN	_	13	compound	_	_
8	homology	homology	NN	NN	_	13	compound	_	_
9	2	2	CD	CD	_	13	nummod	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	SH2	sh2	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	domain	domain	NN	NN	_	4	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	corresponding	corresponding	JJ	JJ	_	18	amod	_	_
17	Stat	stat	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	Stat	stat	NN	NN	_	13	nsubj	_	_
3	binding	bind	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	strongly	strongly	RB	RB	_	13	advmod	_	_
13	depends	depend	VBZ	VBZ	_	27	advcl	_	_
14	on	on	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	phosphotyrosine	phosphotyrosine	NN	NN	_	17	compound	_	_
17	residue	residue	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	27	punct	_	_
19	the	the	DT	DT	_	20	det	_	_
20	recruitment	recruitment	NN	NN	_	27	nsubjpass	_	_
21	of	of	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	Stat	stat	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	20	nmod	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	dictated	dictate	VBN	VBN	_	0	root	_	_
28	by	by	IN	IN	_	31	case	_	_
29	amino	amino	NN	NN	_	31	compound	_	_
30	acid	acid	NN	NN	_	31	compound	_	_
31	residues	residue	NNS	NNS	_	27	nmod	_	_
32	C-terminal	c-terminal	JJ	JJ	_	31	amod	_	_
33	to	to	TO	TO	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	phosphotyrosine	phosphotyrosine	NN	NN	_	27	nmod	_	_
36	.	.	.	.	_	27	punct	_	_

1	Specific	specific	JJ	JJ	_	3	amod	_	_
2	docking	docking	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	10	nsubjpass	_	_
4	within	within	IN	IN	_	7	case	_	_
5	individual	individual	JJ	JJ	_	7	amod	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	3	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	15	case	_	_
12	almost	almost	RB	RB	_	13	advmod	_	_
13	all	all	DT	DT	_	15	amod	_	_
14	Stat	stat	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	direct	direct	JJ	JJ	_	3	amod	_	_
3	coupling	coupling	NN	NN	_	10	nsubj	_	_
4	between	between	IN	IN	_	6	case	_	_
5	cytokine	cytokine	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	6	conj	_	_
10	helps	help	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	explain	explain	VB	VB	_	10	xcomp	_	_
13	how	how	WRB	WRB	_	14	advmod	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	16	nsubj	_	_
16	elicit	elicit	VBP	VBP	_	12	ccomp	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	patterns	pattern	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	Cell-to-cell	cell-to-cell	JJ	JJ	_	2	amod	_	_
2	contact	contact	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	long	long	JJ	JJ	_	7	amod	_	_
6	terminal	terminal	JJ	JJ	_	7	amod	_	_
7	repeat	repeat	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
11	virus	virus	NN	NN	_	7	nmod	_	_
12	1	1	CD	CD	_	11	nummod	_	_
13	through	through	IN	IN	_	16	case	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	kappaB	kappab	NN	NN	_	16	compound	_	_
16	motif	motif	NN	NN	_	3	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Cell-to-cell	cell-to-cell	JJ	JJ	_	2	amod	_	_
2	contact	contact	NN	NN	_	15	nsubj	_	_
3	between	between	IN	IN	_	6	case	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	transfected	transfect	VBN	VBN	_	14	amod	_	_
9	human	human	JJ	JJ	_	14	amod	_	_
10	colonic	colonic	JJ	JJ	_	14	amod	_	_
11	carcinoma	carcinoma	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	line	line	NN	NN	_	14	compound	_	_
14	HT29	ht29	NN	NN	_	6	conj	_	_
15	activates	activate	VBZ	VBZ	_	0	root	_	_
16	transcription	transcription	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	long	long	JJ	JJ	_	21	amod	_	_
20	terminal	terminal	JJ	JJ	_	21	amod	_	_
21	repeats	repeat	NNS	NNS	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	LTR	ltr	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	of	of	IN	IN	_	28	case	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	immunodeficiency	immunodeficiency	NN	NN	_	28	compound	_	_
28	virus	virus	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	LTR	ltr	NNS	NNS	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	controlled	control	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	complex	complex	JJ	JJ	_	9	amod	_	_
9	array	array	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	virus-encoded	virus-encoded	JJ	JJ	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	cellular	cellular	JJ	JJ	_	11	conj	_	_
14	proteins	protein	NNS	NNS	_	11	dep	_	_
15	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	various	various	JJ	JJ	_	3	amod	_	_
3	constructs	construct	NNS	NNS	_	1	dobj	_	_
4	expressing	express	VBG	VBG	_	3	acl	_	_
5	a	a	DT	DT	_	8	det	_	_
6	lacZ	lacz	NN	NN	_	8	compound	_	_
7	reporter	reporter	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	dobj	_	_
9	under	under	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	control	control	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	intact	intact	JJ	JJ	_	11	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	three	three	CD	CD	_	17	nummod	_	_
17	deleted	deleted	JJ	JJ	_	14	conj	_	_
18	forms	form	NNS	NNS	_	14	dep	_	_
19	of	of	IN	IN	_	21	case	_	_
20	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
21	LTR	ltr	NNS	NNS	_	14	nmod	_	_
22	,	,	,	,	_	1	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	obtained	obtain	VBD	VBD	_	1	parataxis	_	_
25	evidence	evidence	NN	NN	_	24	dobj	_	_
26	that	that	IN	IN	_	37	mark	_	_
27	the	the	DT	DT	_	30	det	_	_
28	kappaB	kappab	NN	NN	_	30	compound	_	_
29	regulatory	regulatory	JJ	JJ	_	30	amod	_	_
30	elements	element	NNS	NNS	_	37	nsubjpass	_	_
31	located	located	JJ	JJ	_	30	amod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	U3	u3	NN	NN	_	35	compound	_	_
35	region	region	NN	NN	_	31	nmod	_	_
36	are	be	VBP	VBP	_	37	auxpass	_	_
37	involved	involve	VBN	VBN	_	25	ccomp	_	_
38	in	in	IN	IN	_	40	case	_	_
39	cell-to-cell	cell-to-cell	JJ	JJ	_	40	amod	_	_
40	activation	activation	NN	NN	_	37	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	HIV-1	hiv-1	NN	NN	_	43	compound	_	_
43	LTR	ltr	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	1	punct	_	_

1	Cell-to-cell	cell-to-cell	JJ	JJ	_	2	amod	_	_
2	contact	contact	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	vitro	vitro	FW	FW	_	4	dep	_	_
6	binding	binding	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	16	case	_	_
8	the	the	DT	DT	_	16	det	_	_
9	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
10	factor	factor	NN	NN	_	16	compound	_	_
11	kappaB	kappab	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
14	)	)	-RRB-	-RRB-	_	16	punct	_	_
15	p50/p65	p50/p65	NN	NN	_	16	compound	_	_
16	heterodimer	heterodimer	NN	NN	_	6	nmod	_	_
17	to	to	TO	TO	_	21	case	_	_
18	an	a	DT	DT	_	21	det	_	_
19	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
20	kappaB	kappab	NN	NN	_	21	compound	_	_
21	oligonucleotide	oligonucleotide	NN	NN	_	6	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Cell-to-cell	cell-to-cell	JJ	JJ	_	3	amod	_	_
2	contact	contact	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	9	auxpass	_	_
7	only	only	RB	RB	_	8	advmod	_	_
8	partially	partially	RB	RB	_	9	advmod	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	100	100	CD	CD	_	12	compound	_	_
12	microM	microm	NN	NN	_	14	amod	_	_
13	pyrrolidine	pyrrolidine	NN	NN	_	14	compound	_	_
14	dithiocarbamate	dithiocarbamate	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	correlated	correlate	VBN	VBN	_	9	conj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	significant	significant	JJ	JJ	_	22	amod	_	_
22	decrease	decrease	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	cellular	cellular	JJ	JJ	_	27	amod	_	_
25	inhibitor	inhibitor	NN	NN	_	27	compound	_	_
26	kappaB	kappab	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	detectable	detectable	JJ	JJ	_	0	root	_	_
7	before	before	IN	IN	_	9	case	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	h	h	NN	NN	_	6	nmod	_	_
10	after	after	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	contact	contact	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	dependent	dependent	JJ	JJ	_	6	conj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	synthesis	synthesis	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Lineage-	lineage-	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	stage-specific	stage-specific	JJ	JJ	_	1	conj	_	_
4	expression	expression	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	8	case	_	_
6	runt	runt	NN	NN	_	8	compound	_	_
7	box	box	NN	NN	_	8	compound	_	_
8	polypeptides	polypeptide	NNS	NNS	_	1	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	primitive	primitive	JJ	JJ	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	definitive	definitive	JJ	JJ	_	10	conj	_	_
13	hematopoiesis	hematopoiesis	NN	NN	_	10	dep	_	_
14	.	.	.	.	_	1	punct	_	_

1	Translocations	translocation	NNS	NNS	_	9	nsubjpass	_	_
2	involving	involve	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	CBFA2	cbfa2	NN	NN	_	6	compound	_	_
6	locus	locus	NN	NN	_	2	dobj	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	leukemia	leukemia	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	11	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	originally	originally	RB	RB	_	5	advmod	_	_
5	named	name	VBN	VBN	_	2	acl	_	_
6	AML1	aml1	NN	NN	_	5	xcomp	_	_
7	,	,	,	,	_	2	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	homologue	homologue	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	Drosophila	drosophila	FW	FW	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	runt	runt	NN	NN	_	11	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	controls	control	VBZ	VBZ	_	16	acl:relcl	_	_
19	early	early	JJ	JJ	_	20	amod	_	_
20	events	event	NNS	NNS	_	18	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	fly	fly	NN	NN	_	23	compound	_	_
23	embryogenesis	embryogenesis	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	clarify	clarify	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	mammalian	mammalian	JJ	JJ	_	8	amod	_	_
7	runt	runt	NN	NN	_	8	compound	_	_
8	products	product	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	normal	normal	JJ	JJ	_	4	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	leukemic	leukemic	JJ	JJ	_	10	conj	_	_
13	hematopoiesis	hematopoiesis	NN	NN	_	10	dep	_	_
14	,	,	,	,	_	2	punct	_	_
15	we	we	PRP	PRP	_	17	nsubj	_	_
16	have	have	VBP	VBP	_	17	aux	_	_
17	studied	study	VBN	VBN	_	2	parataxis	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	pattern	pattern	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	expression	expression	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	mouse	mouse	NN	NN	_	25	compound	_	_
24	hematopoietic	hematopoietic	JJ	JJ	_	25	amod	_	_
25	tissues	tissue	NNS	NNS	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	adult	adult	JJ	JJ	_	25	nmod	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	during	during	IN	IN	_	31	case	_	_
31	ontogeny	ontogeny	NN	NN	_	25	conj	_	_
32	using	use	VBG	VBG	_	17	xcomp	_	_
33	an	a	DT	DT	_	36	det	_	_
34	anti-runt	anti-runt	JJ	JJ	_	36	amod	_	_
35	box	box	NN	NN	_	36	compound	_	_
36	antiserum	antiserum	NN	NN	_	32	dobj	_	_
37	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	adult	adult	JJ	JJ	_	5	amod	_	_
4	bone	bone	NN	NN	_	5	compound	_	_
5	marrow	marrow	NN	NN	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	found	find	VBD	VBD	_	0	root	_	_
9	expression	expression	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	runt	runt	NN	NN	_	12	compound	_	_
12	polypeptides	polypeptide	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	differentiating	differentiate	VBG	VBG	_	16	amod	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	in	in	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	Within	within	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	erythroid	erythroid	JJ	JJ	_	4	amod	_	_
4	lineage	lineage	NN	NN	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	runt	runt	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	biphasic	biphasic	JJ	JJ	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	clearly	clearly	RB	RB	_	12	advmod	_	_
12	present	present	JJ	JJ	_	9	dep	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	erythroblasts	erythroblast	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	early	early	JJ	JJ	_	19	amod	_	_
18	blood	blood	NN	NN	_	19	compound	_	_
19	islands	island	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	fetal	fetal	JJ	JJ	_	24	amod	_	_
24	liver	liver	NN	NN	_	19	conj	_	_
25	,	,	,	,	_	9	punct	_	_
26	but	but	CC	CC	_	9	cc	_	_
27	absent	absent	JJ	JJ	_	9	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	adult	adult	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Biochemical	biochemical	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	12	nsubj	_	_
3	by	by	IN	IN	_	5	case	_	_
4	Western	western	NN	NN	_	5	compound	_	_
5	blotting	blotting	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	fetal	fetal	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	adult	adult	JJ	JJ	_	7	conj	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
11	populations	population	NNS	NNS	_	7	dep	_	_
12	shows	show	VBZ	VBZ	_	0	root	_	_
13	several	several	JJ	JJ	_	15	amod	_	_
14	runt	runt	JJ	JJ	_	15	amod	_	_
15	isoforms	isoform	NNS	NNS	_	12	dobj	_	_
16	.	.	.	.	_	12	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	least	least	JJS	JJS	_	3	advmod	_	_
3	one	one	CD	CD	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	them	they	PRP	PRP	_	3	nmod	_	_
6	appears	appear	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	be	be	VB	VB	_	10	cop	_	_
9	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
10	specific	specific	JJ	JJ	_	6	xcomp	_	_
11	.	.	.	.	_	6	punct	_	_

1	Cytokine	cytokine	NN	NN	_	3	compound	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	networks	network	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	a	a	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	era	era	NN	NN	_	3	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	biomedical	biomedical	JJ	JJ	_	10	amod	_	_
10	research	research	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Elucidation	elucidation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	biochemical	biochemical	JJ	JJ	_	5	amod	_	_
5	nature	nature	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	signal	signal	NN	NN	_	10	compound	_	_
9	transduction	transduction	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	5	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	regulate	regulate	VBP	VBP	_	10	acl:relcl	_	_
13	transcription	transcription	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	replication	replication	NN	NN	_	13	conj	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	the	the	DT	DT	_	18	det	_	_
18	focus	focus	NN	NN	_	0	root	_	_
19	of	of	IN	IN	_	20	case	_	_
20	attention	attention	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	molecular	molecular	JJ	JJ	_	23	amod	_	_
23	biology	biology	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	research	research	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	make	make	VB	VB	_	0	root	_	_
5	feasible	feasible	JJ	JJ	_	6	amod	_	_
6	manipulation	manipulation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	growth	growth	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	differentiation	differentiation	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	mammalian	mammalian	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	which	which	WDT	WDT	_	19	nsubj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	turn	turn	NN	NN	_	19	nmod	_	_
18	would	would	MD	MD	_	19	aux	_	_
19	have	have	VB	VB	_	6	acl:relcl	_	_
20	profound	profound	JJ	JJ	_	21	amod	_	_
21	implication	implication	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	biomedical	biomedical	JJ	JJ	_	24	amod	_	_
24	research	research	NN	NN	_	19	nmod	_	_
25	on	on	IN	IN	_	26	case	_	_
26	cell	cell	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	gene	gene	NN	NN	_	26	conj	_	_
29	therapy	therapy	NN	NN	_	26	dep	_	_
30	,	,	,	,	_	24	punct	_	_
31	and	and	CC	CC	_	24	cc	_	_
32	development	development	NN	NN	_	24	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	pharmaceutical	pharmaceutical	JJ	JJ	_	35	amod	_	_
35	products	product	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	2	nsubj	_	_
2	control	control	VBP	VBP	_	0	root	_	_
3	growth	growth	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	differentiation	differentiation	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	death	death	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	function	function	NN	NN	_	3	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	lymphocytic	lymphocytic	JJ	JJ	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	hemopoietic	hemopoietic	JJ	JJ	_	14	appos	_	_
17	systems	system	NNS	NNS	_	14	dep	_	_
18	,	,	,	,	_	2	punct	_	_
19	and	and	CC	CC	_	2	cc	_	_
20	together	together	RB	RB	_	23	advmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	nerve	nerve	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	2	conj	_	_
24	provide	provide	VBP	VBP	_	2	dep	_	_
25	a	a	DT	DT	_	27	det	_	_
26	pertinent	pertinent	JJ	JJ	_	27	amod	_	_
27	model	model	NN	NN	_	24	dobj	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	study	study	VB	VB	_	27	acl	_	_
30	intercellular	intercellular	JJ	JJ	_	31	amod	_	_
31	communications	communication	NNS	NNS	_	29	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	intercellular	intercellular	JJ	JJ	_	35	amod	_	_
34	signal	signal	NN	NN	_	35	compound	_	_
35	networks	network	NNS	NNS	_	31	conj	_	_
36	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	outlines	outline	VBZ	VBZ	_	0	root	_	_
4	general	general	JJ	JJ	_	5	amod	_	_
5	features	feature	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	signal	signal	NN	NN	_	8	compound	_	_
8	transduction	transduction	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	aspects	aspect	NNS	NNS	_	16	nsubjpass	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	networks	network	NNS	NNS	_	11	nmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	discussed	discuss	VBN	VBN	_	3	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	emphasis	emphasis	NN	NN	_	16	nmod	_	_
19	on	on	IN	IN	_	18	acl	_	_
20	:	:	:	:	_	3	punct	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	regulation	regulation	NN	NN	_	3	dep	_	_
23	of	of	IN	IN	_	24	case	_	_
24	Th1	th1	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Th2-specific	th2-specific	JJ	JJ	_	24	conj	_	_
27	cytokine	cytokine	NN	NN	_	28	compound	_	_
28	genes	gene	NNS	NNS	_	24	dep	_	_
29	in	in	IN	IN	_	31	case	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	22	nmod	_	_
32	,	,	,	,	_	22	punct	_	_
33	the	the	DT	DT	_	34	det	_	_
34	roles	role	NNS	NNS	_	22	conj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	cytokines	cytokine	NNS	NNS	_	34	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	their	they	PRP$	PRP$	_	39	nmod:poss	_	_
39	receptors	receptor	NNS	NNS	_	36	conj	_	_
40	in	in	IN	IN	_	41	case	_	_
41	growth	growth	NN	NN	_	34	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	differentiation	differentiation	NN	NN	_	41	conj	_	_
44	of	of	IN	IN	_	46	case	_	_
45	hemopoietic	hemopoietic	JJ	JJ	_	46	amod	_	_
46	cells	cell	NNS	NNS	_	41	nmod	_	_
47	,	,	,	,	_	22	punct	_	_
48	and	and	CC	CC	_	22	cc	_	_
49	the	the	DT	DT	_	50	det	_	_
50	manipulation	manipulation	NN	NN	_	22	conj	_	_
51	of	of	IN	IN	_	53	case	_	_
52	cytokine	cytokine	NN	NN	_	53	compound	_	_
53	networks	network	NNS	NNS	_	50	nmod	_	_
54	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	5	nsubj	_	_
4	potently	potently	RB	RB	_	5	advmod	_	_
5	up-regulates	up-regulate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	RANTES	rantes	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	13	det	_	_
13	chemokine	chemokine	NN	NN	_	10	appos	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	blocks	block	VBZ	VBZ	_	13	acl:relcl	_	_
16	HIV	hiv	NN	NN	_	17	compound	_	_
17	infection	infection	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	complex	complex	JJ	JJ	_	3	amod	_	_
3	network	network	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	cytokines	cytokine	NNS	NNS	_	3	nmod	_	_
6	that	that	WDT	WDT	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	5	acl:relcl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	inflammatory	inflammatory	JJ	JJ	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	immunoregulatory	immunoregulatory	JJ	JJ	_	10	conj	_	_
13	responses	response	NNS	NNS	_	10	dep	_	_
14	plays	play	VBZ	VBZ	_	0	root	_	_
15	a	a	DT	DT	_	17	det	_	_
16	critical	critical	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	pathogenesis	pathogenesis	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	HIV	hiv	NN	NN	_	23	compound	_	_
23	infection	infection	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	RANTES	rantes	NN	NN	_	16	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	9	punct	_	_
3	regulated	regulate	VBN	VBN	_	9	amod	_	_
4	upon	upon	IN	IN	_	9	amod	_	_
5	activation	activation	NN	NN	_	9	compound	_	_
6	,	,	,	,	_	9	punct	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cell	cell	NN	NN	_	1	appos	_	_
10	expressed	express	VBN	VBN	_	9	amod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	secreted	secrete	VBN	VBN	_	9	conj	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	cytokine	cytokine	NN	NN	_	0	root	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	belongs	belong	VBZ	VBZ	_	16	acl:relcl	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	beta-chemokine	beta-chemokine	NN	NN	_	22	compound	_	_
22	family	family	NN	NN	_	18	nmod	_	_
23	;	;	:	:	_	16	punct	_	_
24	it	it	PRP	PRP	_	26	nsubj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	chemoattractant	chemoattractant	JJ	JJ	_	16	parataxis	_	_
27	for	for	IN	IN	_	30	case	_	_
28	CD4+/CD45RO	cd4+/cd45ro	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	,	,	,	,	_	26	punct	_	_
32	it	it	PRP	PRP	_	34	nsubjpass	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	produced	produce	VBN	VBN	_	26	parataxis	_	_
35	by	by	IN	IN	_	38	case	_	_
36	various	various	JJ	JJ	_	38	amod	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	types	type	NNS	NNS	_	34	nmod	_	_
39	including	include	VBG	VBG	_	40	case	_	_
40	CD8+	cd8+	JJ	JJ	_	38	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	CD4+	cd4+	JJ	JJ	_	40	conj	_	_
43	T	t	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	40	dep	_	_
45	as	as	RB	RB	_	40	cc	_	_
46	well	well	RB	RB	_	45	mwe	_	_
47	as	as	IN	IN	_	45	mwe	_	_
48	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	40	conj	_	_
49	,	,	,	,	_	34	punct	_	_
50	and	and	CC	CC	_	34	cc	_	_
51	has	have	VBZ	VBZ	_	54	aux	_	_
52	recently	recently	RB	RB	_	54	advmod	_	_
53	been	be	VBN	VBN	_	54	auxpass	_	_
54	shown	show	VBN	VBN	_	34	conj	_	_
55	to	to	TO	TO	_	56	mark	_	_
56	suppress	suppress	VB	VB	_	54	xcomp	_	_
57	replication	replication	NN	NN	_	56	dobj	_	_
58	of	of	IN	IN	_	60	case	_	_
59	macrophage-tropic	macrophage-tropic	JJ	JJ	_	60	amod	_	_
60	strains	strain	NNS	NNS	_	57	nmod	_	_
61	of	of	IN	IN	_	62	case	_	_
62	HIV	hiv	NN	NN	_	60	nmod	_	_
63	in	in	IN	IN	_	66	case	_	_
64	CD4+	cd4+	JJ	JJ	_	66	amod	_	_
65	T	t	NN	NN	_	66	compound	_	_
66	cells	cell	NNS	NNS	_	57	nmod	_	_
67	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	RANTES	rantes	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	the	the	DT	DT	_	13	det	_	_
11	RANTES	rantes	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	region	region	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	analyzed	analyze	VBN	VBN	_	2	parataxis	_	_
16	by	by	IN	IN	_	18	case	_	_
17	transient	transient	JJ	JJ	_	18	amod	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	gel-mobility	gel-mobility	JJ	JJ	_	21	amod	_	_
21	shift	shift	NN	NN	_	18	conj	_	_
22	assays	assay	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	:	:	:	:	_	11	punct	_	_
5	1	1	LS	LS	_	11	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	RANTES	rantes	NN	NN	_	9	compound	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	up-regulated	up-regulate	VBN	VBN	_	2	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	PMA	pma	NN	NN	_	11	nmod	_	_
14	plus	plus	CC	CC	_	13	cc	_	_
15	ionomycin	ionomycin	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	coexpression	coexpression	NN	NN	_	13	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	p65	p65	NN	NN	_	21	compound	_	_
21	subunit	subunit	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	29	case	_	_
23	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
24	factor	factor	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	NF	nf	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	-kappa	-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	21	nmod	_	_
30	,	,	,	,	_	13	punct	_	_
31	the	the	DT	DT	_	33	det	_	_
32	proinflammatory	proinflammatory	JJ	JJ	_	33	amod	_	_
33	cytokines	cytokine	NNS	NNS	_	13	conj	_	_
34	TNF-alpha	tnf-alpha	NN	NN	_	33	dep	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	IL-1	il-1	NN	NN	_	37	compound	_	_
37	beta	beta	NN	NN	_	34	conj	_	_
38	,	,	,	,	_	13	punct	_	_
39	and	and	CC	CC	_	13	cc	_	_
40	the	the	DT	DT	_	43	det	_	_
41	CD28	cd28	NN	NN	_	43	compound	_	_
42	costimulatory	costimulatory	JJ	JJ	_	43	amod	_	_
43	pathway	pathway	NN	NN	_	13	conj	_	_
44	;	;	:	:	_	11	punct	_	_
45	2	2	LS	LS	_	51	dep	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	the	the	DT	DT	_	50	det	_	_
48	RANTES	rantes	NN	NN	_	50	compound	_	_
49	promoter	promoter	NN	NN	_	50	compound	_	_
50	region	region	NN	NN	_	51	nsubj	_	_
51	contains	contain	VBZ	VBZ	_	11	conj	_	_
52	four	four	CD	CD	_	56	nummod	_	_
53	NF-kappa	nf-kappa	NN	NN	_	56	compound	_	_
54	B	b	NN	NN	_	56	compound	_	_
55	binding	binding	NN	NN	_	56	compound	_	_
56	sites	site	NNS	NNS	_	51	dobj	_	_
57	at	at	IN	IN	_	58	case	_	_
58	positions	position	NNS	NNS	_	51	nmod	_	_
59	-30	-30	CD	CD	_	58	dep	_	_
60	,	,	,	,	_	58	punct	_	_
61	-44	-44	CD	CD	_	58	conj	_	_
62	,	,	,	,	_	58	punct	_	_
63	-213	-213	CD	CD	_	58	conj	_	_
64	,	,	,	,	_	58	punct	_	_
65	and	and	CC	CC	_	58	cc	_	_
66	-579	-579	CD	CD	_	58	conj	_	_
67	relative	relative	JJ	JJ	_	58	amod	_	_
68	to	to	TO	TO	_	72	case	_	_
69	the	the	DT	DT	_	72	det	_	_
70	transcription	transcription	NN	NN	_	72	compound	_	_
71	start	start	NN	NN	_	72	compound	_	_
72	site	site	NN	NN	_	67	nmod	_	_
73	;	;	:	:	_	11	punct	_	_
74	3	3	LS	LS	_	93	dep	_	_
75	)	)	-RRB-	-RRB-	_	74	punct	_	_
76	one	one	CD	CD	_	77	nummod	_	_
77	site	site	NN	NN	_	93	nsubj	_	_
78	(	(	-LRB-	-LRB-	_	79	punct	_	_
79	-213	-213	CD	CD	_	77	appos	_	_
80	)	)	-RRB-	-RRB-	_	79	punct	_	_
81	is	be	VBZ	VBZ	_	93	cop	_	_
82	an	a	DT	DT	_	93	det	_	_
83	NF-AT	nf-at	NN	NN	_	93	compound	_	_
84	(	(	-LRB-	-LRB-	_	93	punct	_	_
85	nuclear	nuclear	JJ	JJ	_	93	amod	_	_
86	factor	factor	NN	NN	_	93	compound	_	_
87	of	of	IN	IN	_	93	amod	_	_
88	activated	activate	VBN	VBN	_	93	amod	_	_
89	T	t	NN	NN	_	93	compound	_	_
90	cells	cell	NNS	NNS	_	93	compound	_	_
91	)	)	-RRB-	-RRB-	_	93	punct	_	_
92	binding	binding	NN	NN	_	93	compound	_	_
93	site	site	NN	NN	_	11	conj	_	_
94	that	that	WDT	WDT	_	96	nsubj	_	_
95	also	also	RB	RB	_	96	advmod	_	_
96	has	have	VBZ	VBZ	_	93	acl:relcl	_	_
97	weak	weak	JJ	JJ	_	98	amod	_	_
98	affinity	affinity	NN	NN	_	96	dobj	_	_
99	to	to	TO	TO	_	101	case	_	_
100	NF-kappa	nf-kappa	NN	NN	_	101	compound	_	_
101	B	b	NN	NN	_	98	nmod	_	_
102	,	,	,	,	_	93	punct	_	_
103	and	and	CC	CC	_	93	cc	_	_
104	the	the	DT	DT	_	107	det	_	_
105	most	most	RBS	RBS	_	106	advmod	_	_
106	distal	distal	JJ	JJ	_	107	amod	_	_
107	site	site	NN	NN	_	112	nsubj	_	_
108	(	(	-LRB-	-LRB-	_	109	punct	_	_
109	-579	-579	CD	CD	_	107	appos	_	_
110	)	)	-RRB-	-RRB-	_	109	punct	_	_
111	also	also	RB	RB	_	112	advmod	_	_
112	serves	serve	VBZ	VBZ	_	93	conj	_	_
113	as	as	IN	IN	_	116	case	_	_
114	a	a	DT	DT	_	116	det	_	_
115	CD28-responsive	cd28-responsive	JJ	JJ	_	116	amod	_	_
116	element	element	NN	NN	_	112	nmod	_	_
117	;	;	:	:	_	11	punct	_	_
118	and	and	CC	CC	_	11	cc	_	_
119	4	4	LS	LS	_	144	dep	_	_
120	)	)	-RRB-	-RRB-	_	119	punct	_	_
121	mutation	mutation	NN	NN	_	144	nsubj	_	_
122	on	on	IN	IN	_	123	case	_	_
123	any	any	DT	DT	_	121	nmod	_	_
124	of	of	IN	IN	_	128	case	_	_
125	those	those	DT	DT	_	128	det	_	_
126	NF-kappa	nf-kappa	NN	NN	_	128	compound	_	_
127	B	b	NN	NN	_	128	compound	_	_
128	sites	site	NNS	NNS	_	123	nmod	_	_
129	or	or	CC	CC	_	121	cc	_	_
130	coexpression	coexpression	NN	NN	_	121	conj	_	_
131	of	of	IN	IN	_	135	case	_	_
132	I	i	NN	NN	_	135	compound	_	_
133	kappa	kappa	NN	NN	_	135	compound	_	_
134	B	b	NN	NN	_	135	compound	_	_
135	alpha	alpha	NN	NN	_	130	nmod	_	_
136	(	(	-LRB-	-LRB-	_	141	punct	_	_
137	cytoplasmic	cytoplasmic	JJ	JJ	_	141	amod	_	_
138	inhibitor	inhibitor	NN	NN	_	141	compound	_	_
139	of	of	IN	IN	_	141	amod	_	_
140	NF-kappa	nf-kappa	NN	NN	_	141	compound	_	_
141	B	b	NN	NN	_	135	appos	_	_
142	)	)	-RRB-	-RRB-	_	141	punct	_	_
143	markedly	markedly	RB	RB	_	144	advmod	_	_
144	reduced	reduce	VBD	VBD	_	11	conj	_	_
145	the	the	DT	DT	_	147	det	_	_
146	promoter	promoter	NN	NN	_	147	compound	_	_
147	activity	activity	NN	NN	_	144	dobj	_	_
148	.	.	.	.	_	2	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	16	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	potent	potent	JJ	JJ	_	9	amod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	7	dep	_	_
9	activator	activator	NN	NN	_	4	appos	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HIV	hiv	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	involved	involve	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	RANTES	rantes	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	24	det	_	_
24	chemokine	chemokine	NN	NN	_	21	appos	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	blocks	block	VBZ	VBZ	_	24	acl:relcl	_	_
27	infection	infection	NN	NN	_	26	dobj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	macrophage-tropic	macrophage-tropic	JJ	JJ	_	30	amod	_	_
30	strains	strain	NNS	NNS	_	27	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	HIV	hiv	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	Response	response	NN	NN	_	0	root	_	_
2	to	to	TO	TO	_	5	case	_	_
3	intranasal	intranasal	JJ	JJ	_	5	amod	_	_
4	fluticasone	fluticasone	NN	NN	_	5	compound	_	_
5	propionate	propionate	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	perennial	perennial	JJ	JJ	_	8	amod	_	_
8	allergic	allergic	JJ	JJ	_	9	amod	_	_
9	rhinitis	rhinitis	NN	NN	_	1	nmod	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	associated	associate	VBN	VBN	_	1	acl	_	_
12	with	with	IN	IN	_	15	case	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	characteristics	characteristic	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	reduction	reduction	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	symptoms	symptom	NNS	NNS	_	4	nmod	_	_
7	due	due	JJ	JJ	_	4	amod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	treatment	treatment	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	corticosteroids	corticosteroid	NNS	NNS	_	9	nmod	_	_
12	varies	vary	VBZ	VBZ	_	1	dep	_	_
13	among	among	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	perennial	perennial	JJ	JJ	_	17	amod	_	_
17	rhinitis	rhinitis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Most	most	JJS	JJS	_	2	amod	_	_
2	patients	patient	NNS	NNS	_	4	nsubj	_	_
3	will	will	MD	MD	_	4	aux	_	_
4	respond	respond	VB	VB	_	0	root	_	_
5	but	but	CC	CC	_	4	cc	_	_
6	a	a	DT	DT	_	8	det	_	_
7	few	few	JJ	JJ	_	8	amod	_	_
8	patients	patient	NNS	NNS	_	9	nsubj	_	_
9	respond	respond	VBP	VBP	_	4	conj	_	_
10	less	less	RBR	RBR	_	9	advmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	drugs	drug	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	1	dep	_	_
5	the	the	DT	DT	_	6	det	_	_
6	association	association	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	reduction	reduction	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	symptoms	symptom	NNS	NNS	_	8	nmod	_	_
11	due	due	JJ	JJ	_	8	amod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	glucocorticoids	glucocorticoid	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	characteristics	characteristic	NNS	NNS	_	13	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	8	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	perennial	perennial	JJ	JJ	_	22	amod	_	_
22	allergic	allergic	JJ	JJ	_	23	amod	_	_
23	rhinitis	rhinitis	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	4	punct	_	_
25	in	in	FW	FW	_	30	amod	_	_
26	vitro	vitro	FW	FW	_	25	dep	_	_
27	glucocorticoid	glucocorticoid	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	studies	study	NNS	NNS	_	32	nsubjpass	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	performed	perform	VBN	VBN	_	4	parataxis	_	_
33	with	with	IN	IN	_	37	case	_	_
34	peripheral	peripheral	JJ	JJ	_	37	amod	_	_
35	blood	blood	NN	NN	_	37	compound	_	_
36	mononuclear	mononuclear	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	using	use	VBG	VBG	_	32	xcomp	_	_
39	dexamethasone	dexamethasone	NN	NN	_	38	dobj	_	_
40	and	and	CC	CC	_	32	cc	_	_
41	in	in	FW	FW	_	43	amod	_	_
42	vitro	vitro	FW	FW	_	41	dep	_	_
43	production	production	NN	NN	_	47	nsubjpass	_	_
44	of	of	IN	IN	_	45	case	_	_
45	mediators	mediator	NNS	NNS	_	43	nmod	_	_
46	were	be	VBD	VBD	_	47	auxpass	_	_
47	measured	measure	VBN	VBN	_	32	conj	_	_
48	.	.	.	.	_	1	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	During	during	IN	IN	_	8	case	_	_
4	a	a	DT	DT	_	8	det	_	_
5	double-blind	double-blind	JJ	JJ	_	6	amod	_	_
6	placebo-controlled	placebo-controlled	JJ	JJ	_	8	amod	_	_
7	crossover	crossover	JJ	JJ	_	8	amod	_	_
8	study	study	NN	NN	_	34	nmod	_	_
9	,	,	,	,	_	34	punct	_	_
10	200	200	CD	CD	_	11	compound	_	_
11	micrograms	microgram	NNS	NNS	_	16	amod	_	_
12	fluticasone	fluticasone	NN	NN	_	16	compound	_	_
13	propionate	propionate	JJ	JJ	_	16	amod	_	_
14	aqueous	aqueous	JJ	JJ	_	16	amod	_	_
15	nasal	nasal	JJ	JJ	_	16	amod	_	_
16	spray	spray	NN	NN	_	34	nsubjpass	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	active	active	JJ	JJ	_	22	amod	_	_
21	treatment	treatment	NN	NN	_	22	compound	_	_
22	period	period	NN	NN	_	16	nmod	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	placebo	placebo	NN	NN	_	16	conj	_	_
26	(	(	-LRB-	-LRB-	_	31	punct	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	placebo	placebo	NN	NN	_	31	compound	_	_
30	treatment	treatment	NN	NN	_	31	compound	_	_
31	period	period	NN	NN	_	25	nmod	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	administered	administer	VBN	VBN	_	1	dep	_	_
35	twice	twice	RB	RB	_	36	advmod	_	_
36	daily	daily	RB	RB	_	34	advmod	_	_
37	for	for	IN	IN	_	39	case	_	_
38	2	2	CD	CD	_	39	nummod	_	_
39	weeks	week	NNS	NNS	_	34	nmod	_	_
40	to	to	TO	TO	_	42	case	_	_
41	22	22	CD	CD	_	42	nummod	_	_
42	patients	patient	NNS	NNS	_	34	nmod	_	_
43	allergic	allergic	JJ	JJ	_	42	amod	_	_
44	to	to	TO	TO	_	47	case	_	_
45	house	house	NN	NN	_	47	compound	_	_
46	dust	dust	NN	NN	_	47	compound	_	_
47	mite	mite	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	1	punct	_	_

1	At	at	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	end	end	NN	NN	_	10	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	both	both	DT	DT	_	7	det	_	_
6	treatment	treatment	NN	NN	_	7	compound	_	_
7	periods	period	NNS	NNS	_	3	nmod	_	_
8	symptoms	symptom	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	scored	score	VBN	VBN	_	0	root	_	_
11	after	after	IN	IN	_	13	case	_	_
12	allergen	allergen	NN	NN	_	13	compound	_	_
13	provocation	provocation	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	100	100	CD	CD	_	13	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	1000	1000	CD	CD	_	15	amod	_	_
18	,	,	,	,	_	15	punct	_	_
19	10000	10000	CD	CD	_	15	amod	_	_
20	BU/mL	bu/ml	NN	NN	_	15	dep	_	_
21	)	)	-RRB-	-RRB-	_	15	punct	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	during	during	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	9.5	9.5	CD	CD	_	26	nummod	_	_
26	hours	hour	NNS	NNS	_	13	conj	_	_
27	after	after	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	challenge	challenge	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	Receptor	receptor	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	7	nsubjpass	_	_
4	with	with	IN	IN	_	5	case	_	_
5	dexamethasone	dexamethasone	NN	NN	_	3	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	performed	perform	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	12	case	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Leukotriene	leukotriene	NN	NN	_	2	compound	_	_
2	B4	b4	NN	NN	_	23	nsubjpass	_	_
3	produced	produce	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	5	case	_	_
5	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	3	advmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	soluble	soluble	JJ	JJ	_	11	amod	_	_
10	interleukin-2	interleukin-2	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	2	conj	_	_
12	released	release	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	12	advmod	_	_
17	and	and	CC	CC	_	2	cc	_	_
18	cortisol	cortisol	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	2	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	plasma	plasma	NN	NN	_	19	nmod	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	determined	determine	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	No	no	DT	DT	_	6	neg	_	_
4	significant	significant	JJ	JJ	_	6	amod	_	_
5	partial	partial	JJ	JJ	_	4	dep	_	_
6	correlations	correlation	NNS	NNS	_	65	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
13	blood	blood	NN	NN	_	17	compound	_	_
14	mononuclear	mononuclear	JJ	JJ	_	17	amod	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	9	nmod	_	_
18	(	(	-LRB-	-LRB-	_	23	punct	_	_
19	6821	6821	CD	CD	_	23	nummod	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	5669	5669	CD	CD	_	19	conj	_	_
22	binding	bind	VBG	VBG	_	23	amod	_	_
23	sites	site	NNS	NNS	_	9	dep	_	_
24	per	per	IN	IN	_	25	case	_	_
25	cell	cell	NN	NN	_	23	nmod	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	and	and	CC	CC	_	9	cc	_	_
28	the	the	DT	DT	_	29	det	_	_
29	affinity	affinity	NN	NN	_	9	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	Kd	kd	NN	NN	_	29	dep	_	_
32	:	:	:	:	_	31	punct	_	_
33	16.5	16.5	CD	CD	_	36	nummod	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	13.51	13.51	CD	CD	_	33	conj	_	_
36	nmol/L	nmol/l	NN	NN	_	31	dep	_	_
37	)	)	-RRB-	-RRB-	_	31	punct	_	_
38	for	for	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	glucocorticoid	glucocorticoid	NN	NN	_	41	compound	_	_
41	receptors	receptor	NNS	NNS	_	29	nmod	_	_
42	with	with	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	symptom	symptom	NN	NN	_	45	compound	_	_
45	score	score	NN	NN	_	6	nmod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	placebo	placebo	NN	NN	_	45	dep	_	_
48	:	:	:	:	_	47	punct	_	_
49	4.3	4.3	CD	CD	_	52	nummod	_	_
50	+/-	+/-	CC	CC	_	49	cc	_	_
51	2.45	2.45	CD	CD	_	49	conj	_	_
52	pts	pt	NNS	NNS	_	47	dep	_	_
53	;	;	:	:	_	47	punct	_	_
54	fluticasone	fluticasone	NN	NN	_	47	dep	_	_
55	:	:	:	:	_	54	punct	_	_
56	2.4	2.4	CD	CD	_	59	nummod	_	_
57	+/-	+/-	CC	CC	_	56	cc	_	_
58	1.55	1.55	CD	CD	_	56	conj	_	_
59	pts	pt	NNS	NNS	_	54	dep	_	_
60	)	)	-RRB-	-RRB-	_	47	punct	_	_
61	after	after	IN	IN	_	63	case	_	_
62	active	active	JJ	JJ	_	63	amod	_	_
63	treatment	treatment	NN	NN	_	45	nmod	_	_
64	were	be	VBD	VBD	_	65	auxpass	_	_
65	found	find	VBN	VBN	_	1	dep	_	_
66	.	.	.	.	_	1	punct	_	_

1	Also	also	RB	RB	_	59	advmod	_	_
2	no	no	DT	DT	_	5	neg	_	_
3	significant	significant	JJ	JJ	_	5	amod	_	_
4	partial	partial	JJ	JJ	_	3	dep	_	_
5	correlations	correlation	NNS	NNS	_	59	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	levels	level	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	leukotriene	leukotriene	NN	NN	_	11	compound	_	_
11	B4	b4	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	45.6	45.6	CD	CD	_	17	dep	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	105.3	105.3	CD	CD	_	13	conj	_	_
16	ng/10(6)	ng/10(6)	CD	CD	_	13	compound	_	_
17	cells	cell	NNS	NNS	_	11	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	produced	produce	VBN	VBN	_	11	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vitro	vitro	FW	FW	_	19	advmod	_	_
24	,	,	,	,	_	11	punct	_	_
25	soluble	soluble	JJ	JJ	_	27	amod	_	_
26	interleukin-2	interleukin-2	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	11	appos	_	_
28	(	(	-LRB-	-LRB-	_	33	punct	_	_
29	734	734	CD	CD	_	33	dep	_	_
30	+/-	+/-	CC	CC	_	29	cc	_	_
31	237	237	CD	CD	_	29	conj	_	_
32	ng/10(6)	ng/10(6)	CD	CD	_	29	compound	_	_
33	cells	cell	NNS	NNS	_	27	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	released	release	VBN	VBN	_	27	acl	_	_
36	by	by	IN	IN	_	37	case	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	35	nmod	_	_
38	in	in	FW	FW	_	39	compound	_	_
39	vitro	vitro	FW	FW	_	35	advmod	_	_
40	and	and	CC	CC	_	8	cc	_	_
41	cortisol	cortisol	NN	NN	_	42	compound	_	_
42	levels	level	NNS	NNS	_	8	conj	_	_
43	(	(	-LRB-	-LRB-	_	47	punct	_	_
44	571	571	CD	CD	_	47	nummod	_	_
45	+/-	+/-	CC	CC	_	44	cc	_	_
46	236	236	CD	CD	_	44	conj	_	_
47	ng/mL	ng/ml	NN	NN	_	42	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	in	in	IN	IN	_	50	case	_	_
50	plasma	plasma	NN	NN	_	42	nmod	_	_
51	with	with	IN	IN	_	54	case	_	_
52	the	the	DT	DT	_	54	det	_	_
53	symptom	symptom	NN	NN	_	54	compound	_	_
54	score	score	NN	NN	_	5	nmod	_	_
55	after	after	IN	IN	_	57	case	_	_
56	active	active	JJ	JJ	_	57	amod	_	_
57	treatment	treatment	NN	NN	_	54	nmod	_	_
58	were	be	VBD	VBD	_	59	auxpass	_	_
59	found	find	VBN	VBN	_	0	root	_	_
60	.	.	.	.	_	59	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	reduction	reduction	NN	NN	_	24	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	symptoms	symptom	NNS	NNS	_	4	nmod	_	_
7	due	due	JJ	JJ	_	4	amod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	topical	topical	JJ	JJ	_	11	amod	_	_
10	fluticasone	fluticasone	NN	NN	_	11	compound	_	_
11	propionate	propionate	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	4	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	rhinitis	rhinitis	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	allergy	allergy	NN	NN	_	15	conj	_	_
18	to	to	TO	TO	_	21	case	_	_
19	house	house	NN	NN	_	21	compound	_	_
20	dust	dust	NN	NN	_	21	compound	_	_
21	mite	mite	NN	NN	_	17	nmod	_	_
22	is	be	VBZ	VBZ	_	24	auxpass	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	correlated	correlate	VBN	VBN	_	1	dep	_	_
25	with	with	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	characteristics	characteristic	NNS	NNS	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	glucocorticoid	glucocorticoid	NN	NN	_	31	compound	_	_
31	receptor	receptor	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	HIV	hiv	NN	NN	_	4	nsubj	_	_
2	does	do	VBZ	VBZ	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	replicate	replicate	VB	VB	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	naive	naive	JJ	JJ	_	9	amod	_	_
7	CD4	cd4	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	stimulated	stimulate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	CD3/CD28	cd3/cd28	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	the	the	DT	DT	_	12	det	_	_
9	T	t	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	tropic	tropic	JJ	JJ	_	12	amod	_	_
12	strain	strain	NN	NN	_	20	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HIV	hiv	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	LAI	lai	NN	NN	_	12	appos	_	_
17	,	,	,	,	_	12	punct	_	_
18	does	do	VBZ	VBZ	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	replicate	replicate	VB	VB	_	6	ccomp	_	_
21	in	in	IN	IN	_	25	case	_	_
22	naive	naive	JJ	JJ	_	25	amod	_	_
23	CD4	cd4	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	stimulated	stimulate	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	28	mark	_	_
28	cross-linking	cross-linking	JJ	JJ	_	26	advcl	_	_
29	CD3	cd3	NN	NN	_	28	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	CD28	cd28	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	LAI	lai	NN	NN	_	5	nsubj	_	_
5	replicates	replicate	VBZ	VBZ	_	0	root	_	_
6	well	well	RB	RB	_	5	advmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	memory	memory	NN	NN	_	11	compound	_	_
9	CD4	cd4	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	stimulated	stimulate	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	same	same	JJ	JJ	_	16	amod	_	_
16	way	way	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Unlike	unlike	IN	IN	_	5	case	_	_
2	this	this	DT	DT	_	5	det	_	_
3	physiologically	physiologically	RB	RB	_	4	advmod	_	_
4	relevant	relevant	JJ	JJ	_	5	amod	_	_
5	stimulation	stimulation	NN	NN	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	PHA	pha	NN	NN	_	8	nsubj	_	_
8	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
9	productive	productive	JJ	JJ	_	11	amod	_	_
10	LAI	lai	NN	NN	_	11	compound	_	_
11	replication	replication	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	naive	naive	JJ	JJ	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	memory	memory	NN	NN	_	14	conj	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	dep	_	_
19	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	conducted	conduct	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	11	case	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	purified	purify	VBN	VBN	_	11	amod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	FACS-isolated	facs-isolated	JJ	JJ	_	7	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	subsets	subset	NNS	NNS	_	4	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	CD4	cd4	NN	NN	_	15	compound	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	identified	identify	VBN	VBN	_	11	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	expression	expression	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	CD45RA	cd45ra	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	CD62L	cd62l	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Remixing	remixing	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	purified	purify	VBN	VBN	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	naive	naive	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	13	nsubj	_	_
11	do	do	VBP	VBP	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	suppress	suppress	VB	VB	_	6	ccomp	_	_
14	LAI	lai	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	memory	memory	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	that	that	IN	IN	_	27	mark	_	_
22	memory	memory	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	27	nsubj	_	_
25	do	do	VBP	VBP	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	restore	restore	VB	VB	_	13	conj	_	_
28	LAI	lai	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	naive	naive	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	suppression	suppression	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	productive	productive	JJ	JJ	_	6	amod	_	_
5	LAI	lai	NN	NN	_	6	compound	_	_
6	replication	replication	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	naive	naive	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	due	due	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	differential	differential	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	viral	viral	JJ	JJ	_	19	amod	_	_
19	coreceptors	coreceptor	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	nor	nor	CC	CC	_	13	cc	_	_
22	is	be	VBZ	VBZ	_	24	cop	_	_
23	it	it	PRP	PRP	_	24	nsubj	_	_
24	due	due	JJ	JJ	_	13	conj	_	_
25	to	to	TO	TO	_	26	case	_	_
26	inhibition	inhibition	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	activation	activation	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	important	important	JJ	JJ	_	32	amod	_	_
32	HIV	hiv	NN	NN	_	28	nmod	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	32	dep	_	_
35	,	,	,	,	_	32	punct	_	_
36	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
37	factor-kappaB	factor-kappab	NN	NN	_	32	appos	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	activator	activator	NN	NN	_	40	compound	_	_
40	protein-1	protein-1	NN	NN	_	37	conj	_	_
41	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inherent	inherent	JJ	JJ	_	3	amod	_	_
3	resistance	resistance	NN	NN	_	22	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	naive	naive	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	productive	productive	JJ	JJ	_	11	amod	_	_
10	HIV	hiv	NN	NN	_	11	compound	_	_
11	infection	infection	NN	NN	_	3	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	coupled	couple	VBN	VBN	_	3	acl	_	_
14	with	with	IN	IN	_	17	case	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	proliferative	proliferative	JJ	JJ	_	17	amod	_	_
17	advantage	advantage	NN	NN	_	13	nmod	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	demonstrated	demonstrate	VBN	VBN	_	13	advcl	_	_
20	here	here	RB	RB	_	19	advmod	_	_
21	,	,	,	,	_	3	punct	_	_
22	provides	provide	VBZ	VBZ	_	0	root	_	_
23	a	a	DT	DT	_	25	det	_	_
24	sound	sound	JJ	JJ	_	25	amod	_	_
25	basis	basis	NN	NN	_	22	dobj	_	_
26	for	for	IN	IN	_	29	case	_	_
27	proposed	proposed	JJ	JJ	_	29	amod	_	_
28	clinical	clinical	JJ	JJ	_	27	dep	_	_
29	therapies	therapy	NNS	NNS	_	25	nmod	_	_
30	using	use	VBG	VBG	_	29	acl	_	_
31	ex	ex	FW	FW	_	33	amod	_	_
32	vivo	vivo	FW	FW	_	31	dep	_	_
33	expansion	expansion	NN	NN	_	30	dobj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	reinfusion	reinfusion	NN	NN	_	33	conj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	CD4	cd4	NN	NN	_	39	compound	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	33	nmod	_	_
40	from	from	IN	IN	_	42	case	_	_
41	HIV-infected	hiv-infected	JJ	JJ	_	42	amod	_	_
42	adults	adult	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Pax-5	pax-5	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	alternatively	alternatively	RB	RB	_	6	advmod	_	_
6	spliced	splice	VBN	VBN	_	0	root	_	_
7	during	during	IN	IN	_	9	case	_	_
8	B-cell	b-cell	NN	NN	_	9	compound	_	_
9	development	development	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	Pax-5	pax-5	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	during	during	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	stages	stage	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	B-cell	b-cell	NN	NN	_	13	compound	_	_
13	differentiation	differentiation	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	influences	influence	VBZ	VBZ	_	6	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	several	several	JJ	JJ	_	21	amod	_	_
20	B-cell-specific	b-cell-specific	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	19	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	existing	exist	VBG	VBG	_	6	amod	_	_
6	isoform	isoform	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Pax-5	pax-5	NN	NN	_	6	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	14	dobj	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	named	name	VBN	VBN	_	8	acl:relcl	_	_
14	Pax-5a	pax-5a	NN	NN	_	13	xcomp	_	_
15	)	)	-RRB-	-RRB-	_	8	punct	_	_
16	,	,	,	,	_	19	punct	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	isolated	isolate	VBN	VBN	_	0	root	_	_
20	three	three	CD	CD	_	22	nummod	_	_
21	new	new	JJ	JJ	_	22	amod	_	_
22	isoforms	isoform	NNS	NNS	_	19	dobj	_	_
23	,	,	,	,	_	22	punct	_	_
24	Pax-5b	pax-5b	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	24	punct	_	_
26	Pax-5d	pax-5d	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	Pax-5e	pax-5e	NN	NN	_	24	conj	_	_
30	,	,	,	,	_	19	punct	_	_
31	from	from	IN	IN	_	33	case	_	_
32	murine	murine	JJ	JJ	_	33	amod	_	_
33	spleen	spleen	NN	NN	_	19	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	B-lymphoid	b-lymphoid	JJ	JJ	_	37	amod	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	33	conj	_	_
38	using	use	VBG	VBG	_	19	xcomp	_	_
39	library	library	NN	NN	_	40	compound	_	_
40	screenings	screening	NNS	NNS	_	38	dobj	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	polymerase	polymerase	NN	NN	_	45	compound	_	_
43	chain	chain	NN	NN	_	45	compound	_	_
44	reaction	reaction	NN	NN	_	45	compound	_	_
45	amplification	amplification	NN	NN	_	40	conj	_	_
46	.	.	.	.	_	19	punct	_	_

1	Isoforms	isoform	NNS	NNS	_	6	nsubj	_	_
2	Pax-5b	pax-5b	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Pax-5e	pax-5e	NN	NN	_	2	conj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	spliced	splice	VBN	VBN	_	0	root	_	_
7	out	out	RP	RP	_	6	compound:prt	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	second	second	JJ	JJ	_	10	amod	_	_
10	exon	exon	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	resulting	result	VBG	VBG	_	6	advcl	_	_
13	in	in	IN	IN	_	14	case	_	_
14	proteins	protein	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	20	case	_	_
16	only	only	RB	RB	_	20	advmod	_	_
17	a	a	DT	DT	_	20	det	_	_
18	partial	partial	JJ	JJ	_	20	amod	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Isoforms	isoform	NNS	NNS	_	6	nsubj	_	_
2	Pax-5d	pax-5d	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Pax-5e	pax-5e	NN	NN	_	2	conj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	deleted	delete	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	3'-region	3'-region	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	encodes	encode	VBZ	VBZ	_	8	acl:relcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transactivating	transactivate	VBG	VBG	_	14	amod	_	_
14	domain	domain	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	replaced	replace	VBN	VBN	_	6	conj	_	_
18	it	it	PRP	PRP	_	17	dobj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	novel	novel	JJ	JJ	_	22	amod	_	_
22	sequence	sequence	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	existence	existence	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	alternative	alternative	JJ	JJ	_	6	amod	_	_
5	Pax-5	pax-5	NN	NN	_	6	compound	_	_
6	transcripts	transcript	NNS	NNS	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	confirmed	confirm	VBN	VBN	_	0	root	_	_
9	using	use	VBG	VBG	_	8	xcomp	_	_
10	RNase	rnase	NN	NN	_	12	compound	_	_
11	protection	protection	NN	NN	_	12	compound	_	_
12	assays	assay	NNS	NNS	_	9	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Pax-5a	pax-5a	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Pax-5b	pax-5b	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	3	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	using	use	VBG	VBG	_	8	xcomp	_	_
10	Western	western	NN	NN	_	12	compound	_	_
11	blot	blot	NN	NN	_	12	compound	_	_
12	analysis	analysis	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	Pax-5a	pax-5a	NN	NN	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	detectable	detectable	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	pro-	pro-	JJ	JJ	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	pre-	pre-	JJ	JJ	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	mature	mature	JJ	JJ	_	5	conj	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	5	dep	_	_
13	,	,	,	,	_	5	punct	_	_
14	but	but	CC	CC	_	5	cc	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	in	in	IN	IN	_	18	case	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	plasmacytomas	plasmacytoma	NNS	NNS	_	5	conj	_	_
19	;	;	:	:	_	3	punct	_	_
20	Pax-5b	pax-5b	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	3	parataxis	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	cop	_	_
25	present	present	JJ	JJ	_	22	xcomp	_	_
26	at	at	IN	IN	_	28	case	_	_
27	low	low	JJ	JJ	_	28	amod	_	_
28	levels	level	NNS	NNS	_	25	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	mature	mature	JJ	JJ	_	32	amod	_	_
31	B-cell	b-cell	NN	NN	_	32	compound	_	_
32	lines	line	NNS	NNS	_	35	nmod	_	_
33	and	and	CC	CC	_	35	cc	_	_
34	,	,	,	,	_	35	punct	_	_
35	unexpectedly	unexpectedly	RB	RB	_	25	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	in	in	IN	IN	_	41	case	_	_
38	one	one	CD	CD	_	41	nummod	_	_
39	plasma	plasma	NN	NN	_	41	compound	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	line	line	NN	NN	_	35	conj	_	_
42	,	,	,	,	_	35	punct	_	_
43	but	but	CC	CC	_	35	cc	_	_
44	not	not	RB	RB	_	46	neg	_	_
45	in	in	IN	IN	_	46	case	_	_
46	pro-B-cell	pro-b-cell	JJ	JJ	_	35	conj	_	_
47	or	or	CC	CC	_	46	cc	_	_
48	T-cell	t-cell	NN	NN	_	46	conj	_	_
49	lines	line	NNS	NNS	_	46	dep	_	_
50	.	.	.	.	_	3	punct	_	_

1	Mobility	mobility	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	9	advmod	_	_
8	translated	translate	VBN	VBN	_	9	amod	_	_
9	Pax-5a	pax-5a	NN	NN	_	20	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Pax-5d	pax-5d	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	9	cc	_	_
15	Pax-5b	pax-5b	NN	NN	_	9	conj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	Pax-5e	pax-5e	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	9	punct	_	_
19	could	could	MD	MD	_	20	aux	_	_
20	interact	interact	VB	VB	_	4	ccomp	_	_
21	with	with	IN	IN	_	26	case	_	_
22	a	a	DT	DT	_	26	det	_	_
23	B-cell-specific	b-cell-specific	JJ	JJ	_	26	amod	_	_
24	activator	activator	NN	NN	_	26	compound	_	_
25	protein-binding	protein-binding	JJ	JJ	_	26	amod	_	_
26	site	site	NN	NN	_	20	nmod	_	_
27	on	on	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	blk	blk	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	this	this	DT	DT	_	3	det	_	_
3	assay	assay	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	1	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	showed	show	VBD	VBD	_	1	parataxis	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	Pax-5d	pax-5d	NN	NN	_	11	nsubj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	present	present	JJ	JJ	_	7	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	some	some	DT	DT	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	but	but	CC	CC	_	20	cc	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	all	all	DT	DT	_	16	dep	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	B-lymphoid	b-lymphoid	JJ	JJ	_	23	amod	_	_
23	lines	line	NNS	NNS	_	16	dep	_	_
24	and	and	CC	CC	_	11	cc	_	_
25	interacts	interact	VBZ	VBZ	_	11	conj	_	_
26	with	with	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	B-cell-specific	b-cell-specific	JJ	JJ	_	31	amod	_	_
29	activator	activator	NN	NN	_	31	compound	_	_
30	protein-binding	protein-binding	JJ	JJ	_	31	amod	_	_
31	site	site	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	differential	differential	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	alternatively	alternatively	RB	RB	_	10	advmod	_	_
8	spliced	splice	VBN	VBN	_	10	amod	_	_
9	Pax-5	pax-5	NN	NN	_	10	compound	_	_
10	isoforms	isoform	NNS	NNS	_	5	nmod	_	_
11	suggests	suggest	VBZ	VBZ	_	0	root	_	_
12	that	that	IN	IN	_	19	mark	_	_
13	they	they	PRP	PRP	_	19	nsubj	_	_
14	may	may	MD	MD	_	19	aux	_	_
15	be	be	VB	VB	_	19	cop	_	_
16	important	important	JJ	JJ	_	19	amod	_	_
17	regulators	regulator	NNS	NNS	_	19	compound	_	_
18	of	of	IN	IN	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	11	ccomp	_	_
20	during	during	IN	IN	_	22	case	_	_
21	B-cell	b-cell	NN	NN	_	22	compound	_	_
22	maturation	maturation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Oxidant-regulation	oxidant-regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	chronically	chronically	RB	RB	_	8	advmod	_	_
8	inflamed	inflamed	JJ	JJ	_	9	amod	_	_
9	intestine	intestine	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	aux	_	_
3	becoming	become	VBG	VBG	_	0	root	_	_
4	increasingly	increasingly	RB	RB	_	5	advmod	_	_
5	apparent	apparent	JJ	JJ	_	3	xcomp	_	_
6	that	that	IN	IN	_	28	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	chronic	chronic	JJ	JJ	_	10	amod	_	_
9	gut	gut	NN	NN	_	10	compound	_	_
10	inflammation	inflammation	NN	NN	_	28	nsubjpass	_	_
11	observed	observe	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	idiopathic	idiopathic	JJ	JJ	_	15	amod	_	_
15	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
16	bowel	bowel	NN	NN	_	17	compound	_	_
17	diseases	disease	NNS	NNS	_	11	nmod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	e.g.	e.g.	FW	FW	_	21	dep	_	_
20	ulcerative	ulcerative	JJ	JJ	_	21	amod	_	_
21	colitis	colitis	NN	NN	_	17	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	Crohn	crohn	NN	NN	_	25	nmod:poss	_	_
24	's	's	POS	POS	_	25	case	_	_
25	disease	disease	NN	NN	_	21	appos	_	_
26	)	)	-RRB-	-RRB-	_	21	punct	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	associated	associate	VBN	VBN	_	3	ccomp	_	_
29	with	with	IN	IN	_	31	case	_	_
30	enhanced	enhance	VBN	VBN	_	31	amod	_	_
31	production	production	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	leukocyte-derived	leukocyte-derived	JJ	JJ	_	34	amod	_	_
34	oxidants	oxidant	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Oxidants	oxidant	NNS	NNS	_	7	nsubjpass	_	_
2	such	such	JJ	JJ	_	5	case	_	_
3	as	as	IN	IN	_	2	mwe	_	_
4	hydrogen	hydrogen	NN	NN	_	5	compound	_	_
5	peroxide	peroxide	NN	NN	_	1	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	known	know	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	7	xcomp	_	_
10	certain	certain	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	dobj	_	_
13	such	such	JJ	JJ	_	19	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
16	transcription	transcription	NN	NN	_	19	compound	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	beta	beta	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	kB	kb	NN	NN	_	13	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	ubiquitous	ubiquitous	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	pleiotropic	pleiotropic	JJ	JJ	_	16	amod	_	_
16	regulator	regulator	NN	NN	_	13	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	numerous	numerous	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	13	nmod	_	_
20	involved	involve	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	immune	immune	JJ	JJ	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	inflammatory	inflammatory	JJ	JJ	_	23	conj	_	_
26	responses	response	NNS	NNS	_	23	dep	_	_
27	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	activated	activate	VBN	VBN	_	0	root	_	_
6	via	via	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	dep	_	_
8	selective	selective	JJ	JJ	_	9	amod	_	_
9	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	ubiquination	ubiquination	NN	NN	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	degradation	degradation	NN	NN	_	9	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
16	inhibitor	inhibitor	NN	NN	_	18	compound	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	I-kB	i-kb	NN	NN	_	9	nmod	_	_
19	thereby	thereby	RB	RB	_	20	advmod	_	_
20	allowing	allow	VBG	VBG	_	5	xcomp	_	_
21	translocation	translocation	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	into	into	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	nucleus	nucleus	NN	NN	_	21	nmod	_	_
28	where	where	WRB	WRB	_	30	advmod	_	_
29	it	it	PRP	PRP	_	30	nsubj	_	_
30	upregulates	upregulate	VBZ	VBZ	_	27	acl:relcl	_	_
31	the	the	DT	DT	_	32	det	_	_
32	transcription	transcription	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	a	a	DT	DT	_	35	det	_	_
35	variety	variety	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	adhesion	adhesion	NN	NN	_	38	compound	_	_
38	molecules	molecule	NNS	NNS	_	35	nmod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	e.g.	e.g.	FW	FW	_	41	dep	_	_
41	ICAM-1	icam-1	NN	NN	_	38	dep	_	_
42	,	,	,	,	_	41	punct	_	_
43	VCAM-1	vcam-1	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	41	punct	_	_
45	,	,	,	,	_	38	punct	_	_
46	cytokines	cytokine	NNS	NNS	_	38	conj	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	TNF	tnf	NN	NN	_	46	dep	_	_
49	,	,	,	,	_	48	punct	_	_
50	IL-1	il-1	NN	NN	_	48	appos	_	_
51	,	,	,	,	_	48	punct	_	_
52	IL-6	il-6	NN	NN	_	48	appos	_	_
53	)	)	-RRB-	-RRB-	_	48	punct	_	_
54	and	and	CC	CC	_	38	cc	_	_
55	enzymes	enzyme	NNS	NNS	_	38	conj	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	iNOS	inos	NN	NN	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proteolytic	proteolytic	JJ	JJ	_	3	amod	_	_
3	degradation	degradation	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	post-translationally	post-translationally	RB	RB	_	7	advmod	_	_
7	modified	modify	VBN	VBN	_	9	amod	_	_
8	I-kappa	i-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	known	know	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	11	xcomp	_	_
15	by	by	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	26S	26s	NN	NN	_	19	compound	_	_
18	proteasome	proteasome	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Based	base	VBN	VBN	_	3	case	_	_
2	upon	upon	IN	IN	_	3	case	_	_
3	work	work	NN	NN	_	9	advcl	_	_
4	from	from	IN	IN	_	6	case	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	laboratory	laboratory	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	propose	propose	VBP	VBP	_	0	root	_	_
10	that	that	IN	IN	_	16	mark	_	_
11	inhibition	inhibition	NN	NN	_	16	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	produces	produce	VBZ	VBZ	_	9	ccomp	_	_
17	significant	significant	JJ	JJ	_	20	amod	_	_
18	anti	anti	JJ	JJ	_	19	amod	_	_
19	inflammatory	inflammatory	JJ	JJ	_	17	dep	_	_
20	activity	activity	NN	NN	_	16	dobj	_	_
21	which	which	WDT	WDT	_	24	nsubjpass	_	_
22	may	may	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	mediated	mediate	VBN	VBN	_	20	acl:relcl	_	_
25	by	by	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	inhibition	inhibition	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	transcription	transcription	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	certain	certain	JJ	JJ	_	33	amod	_	_
32	pro-inflammatory	pro-inflammatory	JJ	JJ	_	33	amod	_	_
33	mediators	mediator	NNS	NNS	_	29	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	adhesion	adhesion	NN	NN	_	36	compound	_	_
36	molecules	molecule	NNS	NNS	_	33	conj	_	_
37	.	.	.	.	_	9	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	LAZ3/BCL6	laz3/bcl6	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	11	case	_	_
5	follicular	follicular	JJ	JJ	_	6	amod	_	_
6	center	center	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	FC	fc	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	1	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	reactive	reactive	JJ	JJ	_	15	amod	_	_
14	lymph	lymph	NN	NN	_	15	compound	_	_
15	nodes	node	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	FC-derived	fc-derived	JJ	JJ	_	19	amod	_	_
18	non-Hodgkin	non-hodgkin	JJ	JJ	_	19	amod	_	_
19	lymphomas	lymphoma	NNS	NNS	_	11	conj	_	_
20	.	.	.	.	_	1	punct	_	_

1	Chromosomal	chromosomal	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	16	nsubjpass	_	_
3	resulting	result	VBG	VBG	_	2	acl	_	_
4	in	in	IN	IN	_	6	case	_	_
5	abnormal	abnormal	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	LAZ3/BCL6	laz3/bcl6	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	implicated	implicate	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	tumorigenesis	tumorigenesis	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	non-Hodgkin	non-hodgkin	JJ	JJ	_	22	amod	_	_
22	lymphoma	lymphoma	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	NHL	nhl	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	16	punct	_	_

1	Therefore	therefore	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	studied	study	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	pattern	pattern	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	LAZ3/BCL6	laz3/bcl6	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	in	in	FW	FW	_	12	amod	_	_
11	situ	situ	FW	FW	_	10	dep	_	_
12	hybridization	hybridization	NN	NN	_	3	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	synthetic	synthetic	JJ	JJ	_	16	amod	_	_
15	oligonucleotide	oligonucleotide	NN	NN	_	16	compound	_	_
16	probes	probe	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	frozen	freeze	VBN	VBN	_	20	amod	_	_
19	tissue	tissue	NN	NN	_	20	compound	_	_
20	sections	section	NNS	NNS	_	3	nmod	_	_
21	from	from	IN	IN	_	25	case	_	_
22	five	five	CD	CD	_	25	nummod	_	_
23	reactive	reactive	JJ	JJ	_	25	amod	_	_
24	lymph	lymph	NN	NN	_	25	compound	_	_
25	nodes	node	NNS	NNS	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	38	38	CD	CD	_	29	nummod	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	cell	cell	NN	NN	_	25	conj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	non-B	non-b	JJ	JJ	_	32	amod	_	_
32	NHL	nhl	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	LAZ3/BCL6	laz3/bcl6	NN	NN	_	7	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	Northern	northern	NN	NN	_	13	compound	_	_
12	blot	blot	NN	NN	_	13	compound	_	_
13	analysis	analysis	NN	NN	_	5	nmod	_	_
14	on	on	IN	IN	_	17	case	_	_
15	multiple	multiple	JJ	JJ	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	tissues	tissue	NNS	NNS	_	5	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	LAZ3/BCL6	laz3/bcl6	NN	NN	_	3	compound	_	_
3	transcript	transcript	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	variety	variety	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	tissues	tissue	NNS	NNS	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	including	include	VBG	VBG	_	14	case	_	_
13	skeletal	skeletal	JJ	JJ	_	14	amod	_	_
14	muscle	muscle	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	leukocytes	leukocyte	NNS	NNS	_	14	appos	_	_
19	,	,	,	,	_	8	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	weakly	weakly	RB	RB	_	25	advmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	normal	normal	JJ	JJ	_	25	amod	_	_
24	lymph	lymph	NN	NN	_	25	compound	_	_
25	nodes	node	NNS	NNS	_	8	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	tumor	tumor	NN	NN	_	4	compound	_	_
4	samples	sample	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	expression	expression	NN	NN	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	LAZ3/BCL6	laz3/bcl6	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	68	68	CD	CD	_	13	nummod	_	_
13	%	%	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	all	all	DT	DT	_	18	det	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	NHL	nhl	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	none	none	NN	NN	_	13	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	non-B	non-b	JJ	JJ	_	24	amod	_	_
24	lymphomas	lymphoma	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	cases	case	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	follicular	follicular	JJ	JJ	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	mixed	mixed	JJ	JJ	_	7	amod	_	_
7	small	small	JJ	JJ	_	4	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	large	large	JJ	JJ	_	7	conj	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lymphomas	lymphoma	NNS	NNS	_	7	dep	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	LAZ3/BCL6	laz3/bcl6	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	confined	confine	VBN	VBN	_	14	acl	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	neoplastic	neoplastic	JJ	JJ	_	19	amod	_	_
19	follicles	follicle	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	follicular	follicular	JJ	JJ	_	4	amod	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	pattern	pattern	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	all	all	DT	DT	_	13	det	_	_
10	non-malignant	non-malignant	JJ	JJ	_	13	amod	_	_
11	reactive	reactive	JJ	JJ	_	10	dep	_	_
12	lymph	lymph	NN	NN	_	13	compound	_	_
13	nodes	node	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Hence	hence	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	LAZ3/BCL6	laz3/bcl6	NN	NN	_	4	nmod	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	correlate	correlate	VB	VB	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	malignancy	malignancy	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	but	but	CC	CC	_	9	cc	_	_
14	reflects	reflect	VBZ	VBZ	_	9	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	origin	origin	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	from	from	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	germinal	germinal	JJ	JJ	_	23	amod	_	_
23	centers	center	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Estrogen	estrogen	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	progesterone	progesterone	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	1	conj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	vernal	vernal	JJ	JJ	_	7	amod	_	_
7	keratoconjunctivitis	keratoconjunctivitis	NN	NN	_	1	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	PURPOSE	purpose	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Sex-related	sex-related	JJ	JJ	_	4	amod	_	_
4	influences	influence	NNS	NNS	_	7	nsubjpass	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	implicated	implicate	VBN	VBN	_	1	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	pathogenesis	pathogenesis	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	vernal	vernal	JJ	JJ	_	13	amod	_	_
13	keratoconjunctivitis	keratoconjunctivitis	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	VKC	vkc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	an	a	DT	DT	_	21	det	_	_
19	allergic	allergic	JJ	JJ	_	20	amod	_	_
20	eosinophilic	eosinophilic	JJ	JJ	_	21	amod	_	_
21	disease	disease	NN	NN	_	13	appos	_	_
22	.	.	.	.	_	7	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	authors	author	NNS	NNS	_	5	nsubj	_	_
5	evaluated	evaluate	VBD	VBD	_	1	dep	_	_
6	tarsal	tarsal	JJ	JJ	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	bulbar	bulbar	JJ	JJ	_	6	conj	_	_
9	conjunctival	conjunctival	JJ	JJ	_	10	amod	_	_
10	biopsies	biopsy	NNS	NNS	_	6	dep	_	_
11	from	from	IN	IN	_	13	case	_	_
12	seven	seven	CD	CD	_	13	nummod	_	_
13	patients	patient	NNS	NNS	_	6	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	severe	severe	JJ	JJ	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	symptomatic	symptomatic	JJ	JJ	_	15	conj	_	_
18	VKC	vkc	NN	NN	_	13	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	5	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	estrogen	estrogen	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	progesterone	progesterone	NN	NN	_	26	compound	_	_
26	receptors	receptor	NNS	NNS	_	23	conj	_	_
27	by	by	IN	IN	_	28	mark	_	_
28	using	use	VBG	VBG	_	5	advcl	_	_
29	monoclonal	monoclonal	JJ	JJ	_	30	amod	_	_
30	antibodies	antibody	NNS	NNS	_	28	dobj	_	_
31	with	with	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	peroxidase-antiperoxidase	peroxidase-antiperoxidase	JJ	JJ	_	34	amod	_	_
34	technique	technique	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Both	both	CC	CC	_	5	cc:preconj	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	epithelium	epithelium	NN	NN	_	28	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	subepithelium	subepithelium	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	tarsal	tarsal	JJ	JJ	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	bulbar	bulbar	JJ	JJ	_	10	conj	_	_
13	conjunctiva	conjunctiva	NN	NN	_	10	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	patients	patient	NNS	NNS	_	10	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	VKC	vkc	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	5	cc	_	_
21	those	those	DT	DT	_	5	conj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	four	four	CD	CD	_	26	nummod	_	_
24	nonatopic	nonatopic	JJ	JJ	_	26	amod	_	_
25	control	control	JJ	JJ	_	26	amod	_	_
26	subjects	subject	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	5	punct	_	_
28	showed	show	VBD	VBD	_	1	dep	_	_
29	intense	intense	JJ	JJ	_	31	amod	_	_
30	positive	positive	JJ	JJ	_	29	dep	_	_
31	staining	staining	NN	NN	_	28	dobj	_	_
32	for	for	IN	IN	_	33	case	_	_
33	estrogen	estrogen	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	progesterone	progesterone	NN	NN	_	36	compound	_	_
36	receptors	receptor	NNS	NNS	_	33	conj	_	_
37	.	.	.	.	_	1	punct	_	_

1	Immunofluorescence	immunofluorescence	NN	NN	_	2	compound	_	_
2	colocalization	colocalization	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	estrogen	estrogen	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	progesterone	progesterone	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	5	conj	_	_
9	with	with	IN	IN	_	12	case	_	_
10	eosinophil	eosinophil	NN	NN	_	12	compound	_	_
11	cationic	cationic	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	2	nmod	_	_
13	showed	show	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	22	mark	_	_
15	approximately	approximately	RB	RB	_	16	advmod	_	_
16	70	70	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	22	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	positive	positive	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	were	be	VBD	VBD	_	22	cop	_	_
22	eosinophils	eosinophil	NNS	NNS	_	13	ccomp	_	_
23	.	.	.	.	_	13	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Sexual	sexual	JJ	JJ	_	4	amod	_	_
4	hormones	hormone	NNS	NNS	_	11	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	through	through	IN	IN	_	8	case	_	_
7	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
8	receptors	receptor	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	influence	influence	VB	VB	_	1	dep	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	eosinophils	eosinophil	NNS	NNS	_	13	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	VKC	vkc	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Use	use	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	new	new	JJ	JJ	_	5	amod	_	_
4	biologic	biologic	JJ	JJ	_	3	dep	_	_
5	markers	marker	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	ovulation	ovulation	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Biological	biological	JJ	JJ	_	2	amod	_	_
2	markers	marker	NNS	NNS	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ovulation	ovulation	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	after	after	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	great	great	JJ	JJ	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	past	past	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	fallen	fall	VBN	VBN	_	0	root	_	_
16	into	into	IN	IN	_	17	case	_	_
17	disuse	disuse	NN	NN	_	15	nmod	_	_
18	for	for	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	large	large	JJ	JJ	_	21	amod	_	_
21	diffusion	diffusion	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	biochemical	biochemical	JJ	JJ	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	biophysical	biophysical	JJ	JJ	_	23	conj	_	_
26	ones	one	NNS	NNS	_	23	dep	_	_
27	.	.	.	.	_	15	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	real	real	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	hormones	hormone	NNS	NNS	_	5	nmod	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	ovulation	ovulation	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	biological	biological	JJ	JJ	_	15	amod	_	_
15	modifications	modification	NNS	NNS	_	12	nmod	_	_
16	on	on	IN	IN	_	18	case	_	_
17	target	target	NN	NN	_	18	compound	_	_
18	tissues	tissue	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	explore	explore	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	modifications	modification	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	reproductive	reproductive	JJ	JJ	_	9	amod	_	_
8	target	target	NN	NN	_	9	compound	_	_
9	tissues	tissue	NNS	NNS	_	4	nmod	_	_
10	as	as	IN	IN	_	12	case	_	_
11	ovulation	ovulation	NN	NN	_	12	compound	_	_
12	markers	marker	NNS	NNS	_	2	nmod	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	studied	study	VBD	VBD	_	2	parataxis	_	_
15	the	the	DT	DT	_	16	det	_	_
16	behaviour	behaviour	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Albuminemia	albuminemia	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	Platelet	platelet	NN	NN	_	21	compound	_	_
21	Factor	factor	NN	NN	_	18	appos	_	_
22	IV	iv	CD	CD	_	21	nummod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	as	as	IN	IN	_	25	case	_	_
25	indicator	indicator	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	Platelet	platelet	NN	NN	_	28	compound	_	_
28	Aggregation	aggregation	NN	NN	_	25	nmod	_	_
29	)	)	-RRB-	-RRB-	_	25	punct	_	_
30	,	,	,	,	_	18	punct	_	_
31	Type	type	NN	NN	_	34	compound	_	_
32	II	ii	CD	CD	_	34	nummod	_	_
33	estrogenic	estrogenic	JJ	JJ	_	34	amod	_	_
34	receptors	receptor	NNS	NNS	_	18	appos	_	_
35	in	in	IN	IN	_	39	case	_	_
36	42	42	CD	CD	_	39	nummod	_	_
37	ovulation	ovulation	NN	NN	_	38	nmod:npmod	_	_
38	induced	induced	JJ	JJ	_	39	amod	_	_
39	women	woman	NNS	NNS	_	18	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	undergoing	undergo	VBG	VBG	_	39	acl	_	_
42	our	we	PRP$	PRP$	_	43	nmod:poss	_	_
43	observation	observation	NN	NN	_	41	dobj	_	_
44	.	.	.	.	_	2	punct	_	_

1	33	33	CD	CD	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	them	they	PRP	PRP	_	1	nmod	_	_
4	had	have	VBD	VBD	_	0	root	_	_
5	ovulation	ovulation	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	9	9	CD	CD	_	8	nsubj	_	_
8	developed	develop	VBD	VBD	_	4	conj	_	_
9	a	a	DT	DT	_	11	det	_	_
10	LUF	luf	NN	NN	_	11	compound	_	_
11	syndrome	syndrome	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	4	punct	_	_
13	constituting	constitute	VBG	VBG	_	4	parataxis	_	_
14	two	two	CD	CD	_	16	nummod	_	_
15	biological	biological	JJ	JJ	_	16	amod	_	_
16	models	model	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	opposite	opposite	JJ	JJ	_	20	amod	_	_
20	situation	situation	NN	NN	_	16	nmod	_	_
21	for	for	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	three	three	CD	CD	_	24	nummod	_	_
24	markers	marker	NNS	NNS	_	13	nmod	_	_
25	observed	observe	VBN	VBN	_	24	acl	_	_
26	.	.	.	.	_	4	punct	_	_

1	All	all	PDT	PDT	_	3	det:predet	_	_
2	the	the	DT	DT	_	3	det	_	_
3	markers	marker	NNS	NNS	_	7	nsubj	_	_
4	considered	consider	VBN	VBN	_	3	acl	_	_
5	were	be	VBD	VBD	_	7	cop	_	_
6	sufficiently	sufficiently	RB	RB	_	7	advmod	_	_
7	sensitive	sensitive	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	but	but	CC	CC	_	7	cc	_	_
10	among	among	IN	IN	_	11	case	_	_
11	them	they	PRP	PRP	_	19	nmod	_	_
12	,	,	,	,	_	19	punct	_	_
13	Platelet	platelet	NN	NN	_	14	compound	_	_
14	Factor	factor	NN	NN	_	19	nsubj	_	_
15	IV	iv	CD	CD	_	14	nummod	_	_
16	was	be	VBD	VBD	_	19	cop	_	_
17	the	the	DT	DT	_	19	det	_	_
18	most	most	RBS	RBS	_	19	advmod	_	_
19	reliable	reliable	JJ	JJ	_	7	conj	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	hormonal	hormonal	JJ	JJ	_	23	amod	_	_
23	ovulatory	ovulatory	JJ	JJ	_	24	amod	_	_
24	situation	situation	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	relA	rela	NN	NN	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	p65	p65	NN	NN	_	1	nmod	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	I	i	NN	NN	_	12	compound	_	_
9	kappa	kappa	NN	NN	_	12	compound	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	subunit	subunit	NN	NN	_	5	conj	_	_
13	expression	expression	NN	NN	_	5	dep	_	_
14	during	during	IN	IN	_	15	case	_	_
15	differentiation	differentiation	NN	NN	_	1	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	evaluated	evaluate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	conj	_	_
9	of	of	IN	IN	_	17	case	_	_
10	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
11	factor	factor	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	NF	nf	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	-kappa	-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	subunits	subunit	NNS	NNS	_	4	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	in	in	IN	IN	_	26	case	_	_
25	monocyte-derived	monocyte-derived	JJ	JJ	_	26	amod	_	_
26	macrophages	macrophage	NNS	NNS	_	22	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	MDMs	mdm	NNS	NNS	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	2	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	4	amod	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	10	nsubjpass	_	_
5	consisting	consist	VBG	VBG	_	4	acl	_	_
6	of	of	IN	IN	_	8	case	_	_
7	p50	p50	NN	NN	_	8	compound	_	_
8	homodimers	homodimer	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	10	nmod	_	_
14	from	from	IN	IN	_	17	case	_	_
15	both	both	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	types	type	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	additional	additional	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	11	nsubj	_	_
4	composed	compose	VBN	VBN	_	3	acl	_	_
5	of	of	IN	IN	_	10	case	_	_
6	p50/RelA	p50/rela	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	p65	p65	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	heterodimers	heterodimer	NNS	NNS	_	4	nmod	_	_
11	appeared	appear	VBD	VBD	_	0	root	_	_
12	only	only	RB	RB	_	15	advmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	11	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	7-day	7-day	JJ	JJ	_	18	amod	_	_
18	MDMs	mdm	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Immunoblot	immunoblot	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	p50	p50	NN	NN	_	7	compound	_	_
7	subunit	subunit	NN	NN	_	10	nsubjpass	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	constitutively	constitutively	RB	RB	_	10	advmod	_	_
10	expressed	express	VBN	VBN	_	3	ccomp	_	_
11	in	in	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	MDMs	mdm	NNS	NNS	_	12	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	9	det	_	_
5	RelA	rela	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	p65	p65	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	subunit	subunit	NN	NN	_	12	nsubj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	barely	barely	RB	RB	_	12	advmod	_	_
12	detectable	detectable	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	but	but	CC	CC	_	12	cc	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	level	level	NN	NN	_	19	nsubj	_	_
19	increased	increase	VBD	VBD	_	12	conj	_	_
20	markedly	markedly	RB	RB	_	19	advmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	MDMs	mdm	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Analysis	analysis	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	RelA	rela	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	p65	p65	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	mRNA	mrna	NN	NN	_	1	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	20	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	stability	stability	NN	NN	_	20	nsubj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	RelA	rela	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	p65	p65	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	mRNA	mrna	NN	NN	_	11	nmod	_	_
18	was	be	VBD	VBD	_	20	cop	_	_
19	significantly	significantly	RB	RB	_	20	advmod	_	_
20	higher	higher	JJR	JJR	_	8	ccomp	_	_
21	in	in	IN	IN	_	22	case	_	_
22	MDMs	mdm	NNS	NNS	_	20	nmod	_	_
23	,	,	,	,	_	20	punct	_	_
24	compared	compare	VBN	VBN	_	26	case	_	_
25	with	with	IN	IN	_	26	case	_	_
26	monocytes	monocyte	NNS	NNS	_	20	advcl	_	_
27	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	MDMs	mdm	NNS	NNS	_	30	nmod	_	_
3	,	,	,	,	_	30	punct	_	_
4	an	a	DT	DT	_	5	det	_	_
5	upregulation	upregulation	NN	NN	_	30	nsubjpass	_	_
6	of	of	IN	IN	_	11	case	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	5	nmod	_	_
12	as	as	RB	RB	_	5	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	the	the	DT	DT	_	16	det	_	_
16	appearance	appearance	NN	NN	_	5	conj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	novel	novel	JJ	JJ	_	22	amod	_	_
20	M(r)	m(r)	NN	NN	_	22	amod	_	_
21	40,000	40,000	CD	CD	_	20	compound	_	_
22	form	form	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	I	i	NN	NN	_	27	compound	_	_
25	kappa	kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	22	nmod	_	_
28	were	be	VBD	VBD	_	30	auxpass	_	_
29	also	also	RB	RB	_	30	advmod	_	_
30	observed	observe	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	macrophage	macrophage	NN	NN	_	6	compound	_	_
6	differentiation	differentiation	NN	NN	_	7	nsubj	_	_
7	results	result	VBZ	VBZ	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	active	active	JJ	JJ	_	17	amod	_	_
13	p50/RelA	p50/rela	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	p65	p65	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	heterodimers	heterodimer	NNS	NNS	_	10	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	capacity	capacity	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	activate	activate	VB	VB	_	20	acl	_	_
23	target	target	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	parallel	parallel	JJ	JJ	_	3	amod	_	_
3	induction	induction	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	I	i	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	3	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	allow	allow	VB	VB	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	continuous	continuous	JJ	JJ	_	15	amod	_	_
15	presence	presence	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	cytoplasmic	cytoplasmic	JJ	JJ	_	19	amod	_	_
19	reservoir	reservoir	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	p50/RelA	p50/rela	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	p65	p65	NN	NN	_	25	compound	_	_
24	)	)	-RRB-	-RRB-	_	25	punct	_	_
25	complexes	complex	NNS	NNS	_	19	nmod	_	_
26	that	that	WDT	WDT	_	29	nsubj	_	_
27	are	be	VBP	VBP	_	29	cop	_	_
28	readily	readily	RB	RB	_	29	advmod	_	_
29	available	available	JJ	JJ	_	25	acl:relcl	_	_
30	for	for	IN	IN	_	32	case	_	_
31	inducer-mediated	inducer-mediated	JJ	JJ	_	32	amod	_	_
32	stimulation	stimulation	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	Requirement	requirement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	prestimulated	prestimulated	JJ	JJ	_	6	amod	_	_
4	THP-1	thp-1	NN	NN	_	6	compound	_	_
5	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	TNF	tnf	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	1	nmod	_	_
5	.	.	.	.	_	1	punct	_	_

1	Blood	blood	NN	NN	_	2	compound	_	_
2	monocytes	monocyte	NNS	NNS	_	4	nsubj	_	_
3	spontaneously	spontaneously	RB	RB	_	4	advmod	_	_
4	activate	activate	VBP	VBP	_	0	root	_	_
5	endothelial	endothelial	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	culture	culture	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	leading	lead	VBG	VBG	_	4	advcl	_	_
11	to	to	TO	TO	_	12	case	_	_
12	adhesion	adhesion	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	onto	onto	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	endothelial	endothelial	JJ	JJ	_	19	amod	_	_
19	surface	surface	NN	NN	_	12	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	overproduction	overproduction	NN	NN	_	12	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	endothelial	endothelial	JJ	JJ	_	24	amod	_	_
24	proteins	protein	NNS	NNS	_	21	nmod	_	_
25	such	such	JJ	JJ	_	29	case	_	_
26	as	as	IN	IN	_	25	mwe	_	_
27	von	von	NN	NN	_	29	compound	_	_
28	Willebrand	willebrand	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	24	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	vWf	vwf	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	plasminogen	plasminogen	NN	NN	_	37	compound	_	_
35	activator	activator	NN	NN	_	37	compound	_	_
36	inhibitor	inhibitor	NN	NN	_	37	compound	_	_
37	type	type	NN	NN	_	29	conj	_	_
38	1	1	CD	CD	_	37	nummod	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	PAI-1	pai-1	NN	NN	_	37	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	overcome	overcome	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	difficulty	difficulty	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	obtaining	obtain	VBG	VBG	_	4	acl	_	_
7	quiescent	quiescent	JJ	JJ	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	6	dobj	_	_
9	,	,	,	,	_	2	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	studied	study	VBD	VBD	_	2	parataxis	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ability	ability	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	promonocytic	promonocytic	JJ	JJ	_	17	amod	_	_
16	THP-1	thp-1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	activate	activate	VB	VB	_	13	acl	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	2	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	nmod:npmod	_	_
2	(	(	-LRB-	-LRB-	_	5	punct	_	_
3	LPS	lps	NN	NN	_	5	nmod:npmod	_	_
4	)	)	-RRB-	-RRB-	_	5	punct	_	_
5	-prestimulated	-prestimulated	JJ	JJ	_	11	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	untreated	untreated	JJ	JJ	_	5	conj	_	_
8	THP-1	thp-1	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	dep	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	cocultured	coculture	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	18	case	_	_
13	resting	rest	VBG	VBG	_	18	amod	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	umbilical	umbilical	JJ	JJ	_	18	amod	_	_
16	vein	vein	NN	NN	_	18	compound	_	_
17	endothelial	endothelial	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HUVEC	huvec	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	for	for	IN	IN	_	26	case	_	_
23	3	3	CD	CD	_	26	nummod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	24	24	CD	CD	_	23	conj	_	_
26	h	h	NN	NN	_	11	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	presence	presence	NN	NN	_	11	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	colimycin	colimycin	NN	NN	_	29	nmod	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	neutralize	neutralize	VB	VB	_	11	xcomp	_	_
34	LPS	lps	NN	NN	_	35	compound	_	_
35	traces	trace	NNS	NNS	_	33	dobj	_	_
36	.	.	.	.	_	11	punct	_	_

1	Addition	addition	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	untreated	untreated	JJ	JJ	_	5	amod	_	_
4	THP-1	thp-1	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	little	little	JJ	JJ	_	8	amod	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	on	on	IN	IN	_	11	case	_	_
10	HUVEC	huvec	NNS	NNS	_	11	compound	_	_
11	adhesiveness	adhesiveness	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Addition	addition	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	prestimulated	prestimulated	JJ	JJ	_	5	amod	_	_
4	THP-1	thp-1	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	followed	follow	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	noticeable	noticeable	JJ	JJ	_	11	amod	_	_
11	adhesion	adhesion	NN	NN	_	7	nmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	3	3	CD	CD	_	14	nummod	_	_
14	h	h	NN	NN	_	7	nmod	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	reversed	reverse	VBD	VBD	_	7	dep	_	_
17	to	to	TO	TO	_	19	case	_	_
18	basal	basal	JJ	JJ	_	19	amod	_	_
19	values	value	NNS	NNS	_	16	nmod	_	_
20	within	within	IN	IN	_	22	case	_	_
21	24	24	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	conditions	condition	NNS	NNS	_	15	nmod	_	_
4	HUVEC	huvec	NNS	NNS	_	6	compound	_	_
5	adhesion	adhesion	NN	NN	_	6	compound	_	_
6	molecules	molecule	NNS	NNS	_	15	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	E-selectin	e-selectin	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	VCAM-1	vcam-1	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	ICAM-1	icam-1	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	increased	increase	VBN	VBN	_	0	root	_	_
16	at	at	IN	IN	_	18	case	_	_
17	3	3	CD	CD	_	18	nummod	_	_
18	h	h	NN	NN	_	15	nmod	_	_
19	with	with	IN	IN	_	22	mark	_	_
20	only	only	RB	RB	_	21	advmod	_	_
21	ICAM-1	icam-1	NN	NN	_	22	nsubj	_	_
22	remaining	remain	VBG	VBG	_	15	advcl	_	_
23	overexpressed	overexpress	VBN	VBN	_	22	xcomp	_	_
24	at	at	IN	IN	_	26	case	_	_
25	24	24	CD	CD	_	26	nummod	_	_
26	h	h	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	15	punct	_	_

1	Diffusible	diffusible	JJ	JJ	_	3	amod	_	_
2	endothelial	endothelial	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	17	nsubj	_	_
4	such	such	JJ	JJ	_	7	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	soluble	soluble	JJ	JJ	_	7	amod	_	_
7	E-selectin	e-selectin	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	PAI-1	pai-1	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	vWf	vwf	NN	NN	_	7	conj	_	_
12	to	to	TO	TO	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	minimal	minimal	JJ	JJ	_	15	amod	_	_
15	extent	extent	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	increased	increase	VBD	VBD	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	supernatants	supernatant	NNS	NNS	_	17	nmod	_	_
20	from	from	IN	IN	_	21	case	_	_
21	HUVEC	huvec	NNS	NNS	_	19	nmod	_	_
22	cocultured	coculture	VBN	VBN	_	21	acl	_	_
23	for	for	IN	IN	_	25	case	_	_
24	24	24	CD	CD	_	25	nummod	_	_
25	h	h	NN	NN	_	22	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	prestimulated	prestimulated	JJ	JJ	_	29	amod	_	_
28	THP-1	thp-1	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	those	those	DT	DT	_	3	det	_	_
3	cocultures	coculture	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	TNF	tnf	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	concentrations	concentration	NNS	NNS	_	8	nsubj	_	_
8	peaked	peak	VBD	VBD	_	0	root	_	_
9	at	at	IN	IN	_	11	case	_	_
10	3	3	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	8	nmod	_	_
12	whereas	whereas	IN	IN	_	15	mark	_	_
13	IL-1	il-1	NN	NN	_	15	compound	_	_
14	beta	beta	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	8	advcl	_	_
16	progressively	progressively	RB	RB	_	15	advmod	_	_
17	rose	rise	VBD	VBD	_	15	dep	_	_
18	until	until	IN	IN	_	20	case	_	_
19	24	24	CD	CD	_	20	nummod	_	_
20	h	h	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Addition	addition	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	an	a	DT	DT	_	6	det	_	_
4	anti-TNF	anti-tnf	JJ	JJ	_	6	amod	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	antibody	antibody	NN	NN	_	1	nmod	_	_
7	decreased	decrease	VBD	VBD	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	40	40	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	7	nmod	_	_
11	E-selectin	e-selectin	NN	NN	_	7	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	ICAM-1	icam-1	NN	NN	_	11	conj	_	_
14	induction	induction	NN	NN	_	11	dep	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	suppressed	suppress	VBD	VBD	_	7	conj	_	_
17	PAI-1	pai-1	NN	NN	_	18	compound	_	_
18	overproduction	overproduction	NN	NN	_	16	dobj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	weak	weak	JJ	JJ	_	22	amod	_	_
22	effect	effect	NN	NN	_	16	nmod	_	_
23	on	on	IN	IN	_	24	case	_	_
24	vWf	vwf	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	anti-IL-1	anti-il-1	JJ	JJ	_	4	amod	_	_
3	beta	beta	NN	NN	_	4	compound	_	_
4	antibody	antibody	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	negligible	negligible	JJ	JJ	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	on	on	IN	IN	_	11	case	_	_
9	HUVEC	huvec	NNS	NNS	_	11	compound	_	_
10	adhesion	adhesion	NN	NN	_	11	compound	_	_
11	molecules	molecule	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	PAI-1	pai-1	NN	NN	_	11	appos	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	vWf	vwf	NN	NN	_	13	conj	_	_
16	production	production	NN	NN	_	13	dep	_	_
17	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	promonocytic	promonocytic	JJ	JJ	_	8	amod	_	_
7	THP-1	thp-1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	require	require	VBP	VBP	_	4	ccomp	_	_
10	prestimulation	prestimulation	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	14	mark	_	_
12	order	order	NN	NN	_	11	mwe	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	activate	activate	VB	VB	_	9	advcl	_	_
15	HUVEC	huvec	NNS	NNS	_	14	dobj	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	TNF	tnf	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	20	nsubj	_	_
20	contributes	contribute	VBZ	VBZ	_	9	conj	_	_
21	to	to	TO	TO	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	phenomenon	phenomenon	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	c-Jun	c-jun	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	GST-pi	gst-pi	NN	NN	_	1	conj	_	_
4	expression	expression	NN	NN	_	1	dep	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	plasma	plasma	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Bone	bone	NN	NN	_	3	compound	_	_
2	marrow	marrow	NN	NN	_	3	compound	_	_
3	samples	sample	NNS	NNS	_	22	nsubjpass	_	_
4	from	from	IN	IN	_	6	case	_	_
5	33	33	CD	CD	_	6	nummod	_	_
6	patients	patient	NNS	NNS	_	3	nmod	_	_
7	affected	affect	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	MM	mm	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	MGUS	mgus	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	8	8	CD	CD	_	15	nummod	_	_
15	patients	patient	NNS	NNS	_	6	conj	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	affected	affect	VBN	VBN	_	15	acl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	lymphoproliferative	lymphoproliferative	JJ	JJ	_	20	amod	_	_
20	diseases	disease	NNS	NNS	_	17	nmod	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	studied	study	VBN	VBN	_	0	root	_	_
23	for	for	IN	IN	_	24	case	_	_
24	expression	expression	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	c-Jun	c-jun	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	a	a	DT	DT	_	29	det	_	_
29	component	component	NN	NN	_	26	dep	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factor	factor	NN	NN	_	29	nmod	_	_
34	AP-1	ap-1	NN	NN	_	33	dep	_	_
35	)	)	-RRB-	-RRB-	_	29	punct	_	_
36	and	and	CC	CC	_	26	cc	_	_
37	glutathione-S-transferase	glutathione-s-transferase	NN	NN	_	38	compound	_	_
38	pi	pi	NN	NN	_	26	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	GST-pi	gst-pi	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	using	use	VBG	VBG	_	22	xcomp	_	_
43	immunocytochemical	immunocytochemical	JJ	JJ	_	44	amod	_	_
44	methods	method	NNS	NNS	_	42	dobj	_	_
45	.	.	.	.	_	22	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	high	high	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	frequent	frequent	JJ	JJ	_	2	conj	_	_
5	expression	expression	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	these	these	DT	DT	_	9	det	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	proteins	protein	NNS	NNS	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	MM	mm	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	MGUS	mgus	NN	NN	_	14	conj	_	_
17	patients	patient	NNS	NNS	_	14	dep	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	31/33	31/33	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	14	dep	_	_
21	positive	positive	JJ	JJ	_	20	amod	_	_
22	for	for	IN	IN	_	23	case	_	_
23	c-Jun	c-jun	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	29/33	29/33	CD	CD	_	26	nummod	_	_
26	patients	patient	NNS	NNS	_	20	conj	_	_
27	positive	positive	JJ	JJ	_	26	amod	_	_
28	for	for	IN	IN	_	29	case	_	_
29	GST-pi	gst-pi	NN	NN	_	27	nmod	_	_
30	)	)	-RRB-	-RRB-	_	20	punct	_	_
31	and	and	CC	CC	_	14	cc	_	_
32	in	in	IN	IN	_	33	case	_	_
33	controls	control	NNS	NNS	_	14	conj	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	affected	affect	VBN	VBN	_	33	acl	_	_
36	by	by	IN	IN	_	38	case	_	_
37	monoclonal	monoclonal	JJ	JJ	_	38	amod	_	_
38	gammopathy	gammopathy	NN	NN	_	35	nmod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	7/8	7/8	CD	CD	_	41	nummod	_	_
41	patients	patient	NNS	NNS	_	33	dep	_	_
42	positive	positive	JJ	JJ	_	41	amod	_	_
43	for	for	IN	IN	_	45	case	_	_
44	both	both	CC	CC	_	45	cc:preconj	_	_
45	c-Jun	c-jun	NN	NN	_	42	nmod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	GST-pi	gst-pi	NN	NN	_	45	conj	_	_
48	)	)	-RRB-	-RRB-	_	41	punct	_	_
49	.	.	.	.	_	11	punct	_	_

1	No	no	DT	DT	_	4	neg	_	_
2	statistically	statistically	RB	RB	_	3	advmod	_	_
3	significant	significant	JJ	JJ	_	4	amod	_	_
4	correlation	correlation	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	between	between	IN	IN	_	8	case	_	_
8	c-Jun-	c-jun-	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GST-pi-positive	gst-pi-positive	JJ	JJ	_	8	conj	_	_
11	plasma	plasma	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	dep	_	_
13	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	two	two	CD	CD	_	6	nummod	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	related	related	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	clinical	clinical	JJ	JJ	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	laboratory	laboratory	NN	NN	_	11	conj	_	_
14	data	datum	NNS	NNS	_	11	dep	_	_
15	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	seem	seem	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	confirm	confirm	VB	VB	_	3	xcomp	_	_
6	a	a	DT	DT	_	8	det	_	_
7	possible	possible	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	complex	complex	NN	NN	_	8	nmod	_	_
13	AP-1	ap-1	NN	NN	_	12	dep	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	activating	activate	VBG	VBG	_	8	acl	_	_
16	GST-pi	gst-pi	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	plasma	plasma	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	distinct	distinct	JJ	JJ	_	3	amod	_	_
3	pathways	pathway	NNS	NNS	_	13	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	interleukin-5	interleukin-5	NN	NN	_	6	compound	_	_
6	synthesis	synthesis	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	allergen-specific	allergen-specific	JJ	JJ	_	11	amod	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	clones	clone	NNS	NNS	_	6	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	suppressed	suppress	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	8	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	GC	gc	NNS	NNS	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	have	have	VBP	VBP	_	8	aux	_	_
6	long	long	RB	RB	_	8	advmod	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	as	as	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	most	most	RBS	RBS	_	12	advmod	_	_
12	effective	effective	JJ	JJ	_	13	amod	_	_
13	agents	agent	NNS	NNS	_	8	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	treatment	treatment	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	allergic	allergic	JJ	JJ	_	19	amod	_	_
19	diseases	disease	NNS	NNS	_	16	nmod	_	_
20	accompanied	accompany	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	eosinophilia	eosinophilia	NN	NN	_	20	nmod	_	_
23	such	such	JJ	JJ	_	26	case	_	_
24	as	as	IN	IN	_	23	mwe	_	_
25	chronic	chronic	JJ	JJ	_	26	amod	_	_
26	asthma	asthma	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	atopic	atopic	JJ	JJ	_	29	amod	_	_
29	dermatitis	dermatitis	NN	NN	_	26	conj	_	_
30	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	development	development	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	chronic	chronic	JJ	JJ	_	5	amod	_	_
5	eosinophilic	eosinophilic	JJ	JJ	_	6	amod	_	_
6	inflammation	inflammation	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	on	on	IN	IN	_	10	case	_	_
10	interleukin-5	interleukin-5	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL-5	il-5	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	10	punct	_	_
15	a	a	DT	DT	_	18	det	_	_
16	selective	selective	JJ	JJ	_	18	amod	_	_
17	eosinophil-activating	eosinophil-activating	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	10	appos	_	_
19	,	,	,	,	_	10	punct	_	_
20	produced	produce	VBN	VBN	_	10	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	helper	helper	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	delineate	delineate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	IL-5	il-5	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	established	establish	VBD	VBD	_	2	parataxis	_	_
13	allergen-specific	allergen-specific	JJ	JJ	_	16	amod	_	_
14	CD4+	cd4+	JJ	JJ	_	16	amod	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	clones	clone	NNS	NNS	_	12	dobj	_	_
17	from	from	IN	IN	_	19	case	_	_
18	asthmatic	asthmatic	JJ	JJ	_	19	amod	_	_
19	patients	patient	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	GC	gc	NNS	NNS	_	3	nsubj	_	_
2	efficiently	efficiently	RB	RB	_	3	advmod	_	_
3	suppressed	suppress	VBD	VBD	_	0	root	_	_
4	IL-5	il-5	NN	NN	_	5	compound	_	_
5	synthesis	synthesis	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	clones	clone	NNS	NNS	_	5	nmod	_	_
9	activated	activate	VBN	VBN	_	5	acl	_	_
10	via	via	IN	IN	_	13	case	_	_
11	either	either	CC	CC	_	13	cc:preconj	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TCR	tcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	or	or	CC	CC	_	13	cc	_	_
18	IL-2	il-2	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	13	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	IL-2R	il-2r	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-5	il-5	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	1	nmod	_	_
5	upon	upon	IN	IN	_	6	case	_	_
6	TCR	tcr	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-2R	il-2r	NN	NN	_	6	conj	_	_
9	stimulation	stimulation	NN	NN	_	6	dep	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	totally	totally	RB	RB	_	12	advmod	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	IL-5	il-5	NN	NN	_	5	compound	_	_
3	promoter/enhancer-luciferase	promoter/enhancer-luciferase	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	construct	construct	NN	NN	_	11	nsubjpass	_	_
6	transfected	transfect	VBN	VBN	_	5	acl	_	_
7	to	to	TO	TO	_	9	case	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	clones	clone	NNS	NNS	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	transcribed	transcribe	VBN	VBN	_	0	root	_	_
12	on	on	IN	IN	_	14	case	_	_
13	either	either	CC	CC	_	14	cc:preconj	_	_
14	TCR	tcr	NN	NN	_	11	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	IL-2R	il-2r	NN	NN	_	14	conj	_	_
17	stimulation	stimulation	NN	NN	_	14	dep	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	clearly	clearly	RB	RB	_	21	advmod	_	_
21	downregulated	downregulate	VBN	VBN	_	11	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	dexamethasone	dexamethasone	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	11	punct	_	_
25	indicating	indicate	VBG	VBG	_	11	advcl	_	_
26	that	that	IN	IN	_	41	mark	_	_
27	the	the	DT	DT	_	33	det	_	_
28	approximately	approximately	RB	RB	_	33	advmod	_	_
29	500-bp	500-bp	JJ	JJ	_	33	amod	_	_
30	human	human	JJ	JJ	_	33	amod	_	_
31	IL-5	il-5	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	segment	segment	NN	NN	_	41	nsubj	_	_
34	located	located	JJ	JJ	_	33	amod	_	_
35	5'	5'	RB	RB	_	36	advmod	_	_
36	upstream	upstream	RB	RB	_	34	nmod	_	_
37	of	of	IN	IN	_	36	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	coding	code	VBG	VBG	_	40	amod	_	_
40	region	region	NN	NN	_	36	dep	_	_
41	contains	contain	VBZ	VBZ	_	25	ccomp	_	_
42	activation-inducible	activation-inducible	JJ	JJ	_	44	amod	_	_
43	enhancer	enhancer	NN	NN	_	44	compound	_	_
44	elements	element	NNS	NNS	_	41	dobj	_	_
45	responsible	responsible	JJ	JJ	_	44	amod	_	_
46	for	for	IN	IN	_	48	case	_	_
47	the	the	DT	DT	_	48	det	_	_
48	regulation	regulation	NN	NN	_	45	nmod	_	_
49	by	by	IN	IN	_	50	case	_	_
50	GC	gc	NNS	NNS	_	48	nmod	_	_
51	.	.	.	.	_	11	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
2	mobility	mobility	NN	NN	_	5	compound	_	_
3	shift	shift	NN	NN	_	5	compound	_	_
4	assay	assay	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	6	nsubj	_	_
6	suggested	suggest	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	AP-1	ap-1	NN	NN	_	15	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	conj	_	_
11	are	be	VBP	VBP	_	15	cop	_	_
12	among	among	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	possible	possible	JJ	JJ	_	15	amod	_	_
15	targets	target	NNS	NNS	_	6	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	GC	gc	NNS	NNS	_	18	compound	_	_
18	actions	action	NNS	NNS	_	15	nmod	_	_
19	on	on	IN	IN	_	22	case	_	_
20	TCR-stimulated	tcr-stimulated	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	NF-AT	nf-at	NN	NN	_	7	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	7	auxpass	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	stimulation	stimulation	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	25	nsubj	_	_
3	showing	show	VBG	VBG	_	2	acl	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	GC	gc	NNS	NNS	_	6	nsubj	_	_
6	suppressed	suppress	VBD	VBD	_	3	ccomp	_	_
7	IL-5	il-5	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	6	dobj	_	_
9	by	by	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	CD4+	cd4+	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	activated	activate	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	18	case	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	stimuli	stimulus	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	TCR	tcr	NN	NN	_	18	appos	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	IL-2R	il-2r	NN	NN	_	20	conj	_	_
23	stimulation	stimulation	NN	NN	_	20	dep	_	_
24	,	,	,	,	_	2	punct	_	_
25	underscore	underscore	VBP	VBP	_	0	root	_	_
26	the	the	DT	DT	_	27	det	_	_
27	efficacy	efficacy	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	GC	gc	NNS	NNS	_	27	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	treatment	treatment	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	allergic	allergic	JJ	JJ	_	35	amod	_	_
35	diseases	disease	NNS	NNS	_	32	nmod	_	_
36	via	via	IN	IN	_	37	case	_	_
37	suppression	suppression	NN	NN	_	32	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	T-cell	t-cell	NN	NN	_	41	compound	_	_
40	IL-5	il-5	NN	NN	_	41	compound	_	_
41	synthesis	synthesis	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	25	punct	_	_

1	Experimental	experimental	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	mice	mouse	NNS	NNS	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	spontaneous	spontaneous	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	2	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	SLE	sle	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	polyomavirus	polyomavirus	NN	NN	_	13	compound	_	_
13	T-antigen	t-antigen	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	0	root	_	_
4	for	for	IN	IN	_	5	case	_	_
5	induction	induction	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	antibodies	antibody	NNS	NNS	_	5	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	DNA	dna	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	eukaryotic	eukaryotic	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	experimental	experimental	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	polyomavirus	polyomavirus	NN	NN	_	13	compound	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	T-antigen	t-antigen	NN	NN	_	7	nmod	_	_
14	has	have	VBZ	VBZ	_	4	ccomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	potential	potential	NN	NN	_	14	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	induce	induce	VB	VB	_	16	acl	_	_
19	anti-DNA	anti-dna	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	18	dobj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	mice	mouse	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	sets	set	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	independent	independent	JJ	JJ	_	5	amod	_	_
5	evidences	evidence	NNS	NNS	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	presented	present	VBN	VBN	_	0	root	_	_
8	here	here	RB	RB	_	7	advmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	demonstrate	demonstrate	VBP	VBP	_	7	dep	_	_
11	a	a	DT	DT	_	13	det	_	_
12	biological	biological	JJ	JJ	_	13	amod	_	_
13	relevance	relevance	NN	NN	_	10	dobj	_	_
14	for	for	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	model	model	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	First	first	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	describe	describe	VBP	VBP	_	0	root	_	_
5	results	result	NNS	NNS	_	4	dobj	_	_
6	demonstrating	demonstrate	VBG	VBG	_	5	acl	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	mice	mouse	NNS	NNS	_	13	nsubj	_	_
9	inoculated	inoculate	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	T-antigen-expressing	t-antigen-expressing	JJ	JJ	_	12	amod	_	_
12	plasmids	plasmid	NNS	NNS	_	9	nmod	_	_
13	produced	produce	VBD	VBD	_	6	ccomp	_	_
14	antibodies	antibody	NNS	NNS	_	13	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	only	only	RB	RB	_	19	cc:preconj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	T-antigen	t-antigen	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	DNA	dna	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	but	but	CC	CC	_	19	cc	_	_
24	also	also	RB	RB	_	19	conj	_	_
25	to	to	TO	TO	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	DNA-binding	dna-binding	JJ	JJ	_	30	amod	_	_
28	eukaryotic	eukaryotic	JJ	JJ	_	30	amod	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	24	nmod	_	_
31	TATA-binding	tata-binding	JJ	JJ	_	32	amod	_	_
32	protein	protein	NN	NN	_	30	dep	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	TBP	tbp	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	24	punct	_	_
37	and	and	CC	CC	_	24	cc	_	_
38	to	to	TO	TO	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	cAMP-response-element-binding	camp-response-element-binding	JJ	JJ	_	41	amod	_	_
41	protein	protein	NN	NN	_	24	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	CREB	creb	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	4	punct	_	_

1	Secondly	secondly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	whether	whether	IN	IN	_	8	mark	_	_
6	polyomavirus	polyomavirus	NN	NN	_	7	compound	_	_
7	reactivation	reactivation	NN	NN	_	8	nsubj	_	_
8	occurs	occur	VBZ	VBZ	_	4	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	SLE	sle	NN	NN	_	11	compound	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	whether	whether	IN	IN	_	27	mark	_	_
15	antibodies	antibody	NNS	NNS	_	27	nsubjpass	_	_
16	to	to	TO	TO	_	17	case	_	_
17	T-antigen	t-antigen	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	DNA	dna	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	to	to	TO	TO	_	23	case	_	_
23	TBP	tbp	NN	NN	_	17	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	CREB	creb	NN	NN	_	23	conj	_	_
26	are	be	VBP	VBP	_	27	auxpass	_	_
27	linked	link	VBN	VBN	_	8	conj	_	_
28	to	to	TO	TO	_	30	case	_	_
29	such	such	JJ	JJ	_	30	amod	_	_
30	events	event	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	7	cc:preconj	_	_
2	within	within	IN	IN	_	7	nmod	_	_
3	and	and	CC	CC	_	7	cc	_	_
4	among	among	IN	IN	_	7	conj	_	_
5	these	these	DT	DT	_	7	det	_	_
6	SLE	sle	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	13	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	frequent	frequent	JJ	JJ	_	11	amod	_	_
10	polyomavirus	polyomavirus	NN	NN	_	11	compound	_	_
11	reactivations	reactivation	NNS	NNS	_	13	nsubjpass	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	that	that	WDT	WDT	_	18	nsubjpass	_	_
15	could	could	MD	MD	_	18	aux	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	explained	explain	VBN	VBN	_	13	dep	_	_
19	by	by	IN	IN	_	21	case	_	_
20	certain	certain	JJ	JJ	_	21	amod	_	_
21	rearrangements	rearrangement	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	noncoding	noncoding	JJ	JJ	_	26	amod	_	_
25	control	control	NN	NN	_	26	compound	_	_
26	regions	region	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	21	punct	_	_
28	nor	nor	CC	CC	_	21	cc	_	_
29	by	by	IN	IN	_	31	case	_	_
30	corticosteroid	corticosteroid	NN	NN	_	31	compound	_	_
31	treatment	treatment	NN	NN	_	21	conj	_	_
32	.	.	.	.	_	13	punct	_	_

1	Linked	link	VBN	VBN	_	0	root	_	_
2	to	to	TO	TO	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	antibodies	antibody	NNS	NNS	_	17	nsubjpass	_	_
7	to	to	TO	TO	_	8	case	_	_
8	T-antigen	t-antigen	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	DNA	dna	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	TBP	tbp	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	CREB	creb	NN	NN	_	8	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	detected	detect	VBN	VBN	_	1	parataxis	_	_
18	,	,	,	,	_	17	punct	_	_
19	identical	identical	JJ	JJ	_	17	advmod	_	_
20	to	to	TO	TO	_	23	mark	_	_
21	what	what	WP	WP	_	23	dobj	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	observed	observe	VBD	VBD	_	19	advcl	_	_
24	in	in	IN	IN	_	25	case	_	_
25	mice	mouse	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	Antibodies	antibody	NNS	NNS	_	6	nsubjpass	_	_
2	recognizing	recognize	VBG	VBG	_	1	acl	_	_
3	double-stranded	double-stranded	JJ	JJ	_	4	amod	_	_
4	DNA	dna	NN	NN	_	2	dobj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	confined	confine	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	frequent	frequent	JJ	JJ	_	12	amod	_	_
11	polyomavirus	polyomavirus	NN	NN	_	12	compound	_	_
12	reactivations	reactivation	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	described	describe	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	24	mark	_	_
7	cognate	cognate	JJ	JJ	_	8	amod	_	_
8	interaction	interaction	NN	NN	_	24	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	recognizing	recognize	VBG	VBG	_	11	acl	_	_
13	DNA	dna	NN	NN	_	12	dobj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	DNA-associated	dna-associated	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	13	conj	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	conj	_	_
20	recognizing	recognize	VBG	VBG	_	19	acl	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	antigen	antigen	NN	NN	_	20	dobj	_	_
23	had	have	VBD	VBD	_	24	aux	_	_
24	taken	take	VBN	VBN	_	5	ccomp	_	_
25	place	place	NN	NN	_	24	dobj	_	_
26	as	as	IN	IN	_	28	case	_	_
27	a	a	DT	DT	_	28	det	_	_
28	consequence	consequence	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	complex	complex	JJ	JJ	_	31	amod	_	_
31	formation	formation	NN	NN	_	28	nmod	_	_
32	between	between	IN	IN	_	34	case	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	ag	ag	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	DNA	dna	NN	NN	_	34	conj	_	_
37	in	in	FW	FW	_	38	compound	_	_
38	vivo	vivo	FW	FW	_	31	advmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	context	context	NN	NN	_	24	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	polyomavirus	polyomavirus	NN	NN	_	44	compound	_	_
44	reactivations	reactivation	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	5	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	an	a	DT	DT	_	6	det	_	_
4	SAF-like	saf-like	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	1	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	serum	serum	NN	NN	_	14	compound	_	_
12	amyloid	amyloid	NN	NN	_	14	compound	_	_
13	A	a	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	monocyte/macrophage	monocyte/macrophage	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	9	nmod	_	_
18	by	by	IN	IN	_	19	case	_	_
19	lipopolysaccharide	lipopolysaccharide	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Serum	serum	NN	NN	_	3	compound	_	_
2	amyloid	amyloid	NN	NN	_	3	compound	_	_
3	A	a	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	SAA	saa	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	linked	link	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	atherosclerosis	atherosclerosis	NN	NN	_	9	nmod	_	_
12	because	because	IN	IN	_	15	case	_	_
13	of	of	IN	IN	_	12	mwe	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	9	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	remodel	remodel	VB	VB	_	15	acl	_	_
18	high-density	high-density	JJ	JJ	_	19	amod	_	_
19	lipoprotein	lipoprotein	NN	NN	_	17	dobj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	depletion	depletion	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	apolipoprotein	apolipoprotein	NN	NN	_	25	compound	_	_
25	A1	a1	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	15	punct	_	_
27	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
28	ability	ability	NN	NN	_	15	conj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	bind	bind	VB	VB	_	28	acl	_	_
31	cholesterol	cholesterol	NN	NN	_	30	dobj	_	_
32	,	,	,	,	_	15	punct	_	_
33	and	and	CC	CC	_	15	cc	_	_
34	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
35	presence	presence	NN	NN	_	15	conj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	atherosclerotic	atherosclerotic	JJ	JJ	_	39	amod	_	_
39	plaques	plaque	NNS	NNS	_	35	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	coronary	coronary	JJ	JJ	_	39	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	carotid	carotid	JJ	JJ	_	41	conj	_	_
44	arteries	artery	NNS	NNS	_	41	dep	_	_
45	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	investigated	investigate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	induction	induction	NN	NN	_	10	compound	_	_
10	mechanism	mechanism	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	SAA	saa	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	THP-1	thp-1	NN	NN	_	17	compound	_	_
16	monocyte/macrophage	monocyte/macrophage	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	play	play	VBP	VBP	_	17	acl:relcl	_	_
20	a	a	DT	DT	_	22	det	_	_
21	critical	critical	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	development	development	NN	NN	_	19	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	atherosclerotic	atherosclerotic	JJ	JJ	_	29	amod	_	_
28	fatty	fatty	JJ	JJ	_	29	amod	_	_
29	streak	streak	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	25	cc	_	_
31	plaque	plaque	NN	NN	_	32	compound	_	_
32	formation	formation	NN	NN	_	25	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	others	other	NNS	NNS	_	1	conj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	SAA	saa	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	induced	induce	VBN	VBN	_	5	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	monocyte/macrophage	monocyte/macrophage	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	lipopolysaccharide	lipopolysaccharide	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LPS	lps	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	5	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	promoter	promoter	NN	NN	_	4	compound	_	_
3	function	function	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	show	show	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	the	the	DT	DT	_	12	det	_	_
10	SAA	saa	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	18	nsubj	_	_
13	between	between	IN	IN	_	14	case	_	_
14	-280	-280	CD	CD	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	-226	-226	CD	CD	_	14	conj	_	_
17	can	can	MD	MD	_	18	aux	_	_
18	confer	confer	VB	VB	_	7	ccomp	_	_
19	LPS	lps	NN	NN	_	20	compound	_	_
20	responsiveness	responsiveness	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Gel	gel	NN	NN	_	5	compound	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	6	nsubj	_	_
6	detected	detect	VBD	VBD	_	0	root	_	_
7	an	a	DT	DT	_	10	det	_	_
8	induced	induce	VBN	VBN	_	10	amod	_	_
9	DNA-binding	dna-binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	10	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	LPS	lps	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Characterization	characterization	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	UV	uv	NN	NN	_	8	compound	_	_
8	cross-linking	cross-linking	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	Southwestern	southwestern	NN	NN	_	11	compound	_	_
11	blot	blot	NN	NN	_	1	appos	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	antibody	antibody	JJ	JJ	_	15	amod	_	_
15	ablation/supershift	ablation/supershift	NN	NN	_	11	conj	_	_
16	assays	assay	NNS	NNS	_	11	dep	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	it	it	PRP	PRP	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	similar	similar	JJ	JJ	_	17	ccomp	_	_
22	to	to	TO	TO	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	recently	recently	RB	RB	_	25	advmod	_	_
25	reported	report	VBN	VBN	_	27	amod	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	factor	factor	NN	NN	_	21	nmod	_	_
28	designated	designate	VBN	VBN	_	27	acl	_	_
29	SAF	saf	NN	NN	_	28	xcomp	_	_
30	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	LPS-mediated	lps-mediated	JJ	JJ	_	8	amod	_	_
6	SAA	saa	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	14	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	monocyte/macrophage	monocyte/macrophage	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	primarily	primarily	RB	RB	_	14	advmod	_	_
14	due	due	JJ	JJ	_	3	ccomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	SAF	saf	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NFAT-family	nfat-family	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	normal	normal	JJ	JJ	_	9	amod	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	NFAT	nfat	NN	NN	_	2	compound	_	_
2	proteins	protein	NNS	NNS	_	3	nsubj	_	_
3	constitute	constitute	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	family	family	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	involved	involve	VBN	VBN	_	5	acl	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	mediating	mediate	VBG	VBG	_	9	advcl	_	_
12	signal	signal	NN	NN	_	13	compound	_	_
13	transduction	transduction	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	3	det	_	_
3	panel	panel	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	specific	specific	JJ	JJ	_	6	amod	_	_
6	antisera	antisera	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	immunoprecipitation	immunoprecipitation	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	1	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	found	find	VBD	VBD	_	1	parataxis	_	_
13	that	that	IN	IN	_	21	mark	_	_
14	NFATp	nfatp	NN	NN	_	21	nsubjpass	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	135	135	CD	CD	_	17	nummod	_	_
17	kDa	kda	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	constitutively	constitutively	RB	RB	_	21	advmod	_	_
21	expressed	express	VBN	VBN	_	12	ccomp	_	_
22	in	in	IN	IN	_	26	case	_	_
23	normal	normal	JJ	JJ	_	26	amod	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	21	punct	_	_
28	while	while	IN	IN	_	40	mark	_	_
29	synthesis	synthesis	NN	NN	_	40	nsubjpass	_	_
30	of	of	IN	IN	_	31	case	_	_
31	NFATc	nfatc	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	predominant	predominant	JJ	JJ	_	34	amod	_	_
34	form	form	NN	NN	_	31	dep	_	_
35	of	of	IN	IN	_	37	case	_	_
36	86	86	CD	CD	_	37	nummod	_	_
37	kDa	kda	NN	NN	_	34	nmod	_	_
38	)	)	-RRB-	-RRB-	_	34	punct	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	induced	induce	VBN	VBN	_	21	advcl	_	_
41	by	by	IN	IN	_	43	case	_	_
42	ionomycin	ionomycin	NN	NN	_	43	compound	_	_
43	treatment	treatment	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	1	punct	_	_

1	NFAT4/x	nfat4/x	NN	NN	_	5	nsubjpass	_	_
2	was	be	VBD	VBD	_	5	auxpass	_	_
3	very	very	RB	RB	_	4	advmod	_	_
4	weakly	weakly	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	unstimulated	unstimulated	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	level	level	NN	NN	_	15	nsubj	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	increase	increase	VB	VB	_	5	conj	_	_
16	upon	upon	IN	IN	_	17	case	_	_
17	treatment	treatment	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	activating	activate	VBG	VBG	_	20	amod	_	_
20	agents	agent	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	NFAT3	nfat3	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	under	under	IN	IN	_	8	case	_	_
7	any	any	DT	DT	_	8	det	_	_
8	conditions	condition	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	Higher-molecular-weight	higher-molecular-weight	JJ	JJ	_	2	amod	_	_
2	species	species	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFATc	nfatc	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	of	of	IN	IN	_	7	case	_	_
7	110	110	CD	CD	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	140	140	CD	CD	_	7	conj	_	_
10	kDa	kda	NN	NN	_	7	dep	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	translation	translation	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NFATc	nfatc	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	apparently	apparently	RB	RB	_	9	advmod	_	_
9	initiates	initiate	VBZ	VBZ	_	0	root	_	_
10	at	at	IN	IN	_	14	case	_	_
11	two	two	CD	CD	_	14	nummod	_	_
12	different	different	JJ	JJ	_	14	amod	_	_
13	AUG	aug	NN	NN	_	14	compound	_	_
14	codons	codon	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	giving	give	VBG	VBG	_	9	xcomp	_	_
17	rise	rise	NN	NN	_	16	dobj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	differ	differ	VBP	VBP	_	19	acl:relcl	_	_
22	in	in	IN	IN	_	23	case	_	_
23	size	size	NN	NN	_	21	nmod	_	_
24	by	by	IN	IN	_	27	case	_	_
25	36	36	CD	CD	_	27	nummod	_	_
26	amino	amino	NN	NN	_	27	compound	_	_
27	acids	acid	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Additional	additional	JJ	JJ	_	3	amod	_	_
2	size	size	NN	NN	_	3	compound	_	_
3	heterogeneity	heterogeneity	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	NFATc	nfatc	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NFATp	nfatp	NN	NN	_	6	conj	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	from	from	IN	IN	_	11	case	_	_
11	phosphorylation	phosphorylation	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	21	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	ionomycin	ionomycin	NN	NN	_	5	compound	_	_
5	treatment	treatment	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	21	punct	_	_
7	exposure	exposure	NN	NN	_	21	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	phorbol	phorbol	NN	NN	_	13	compound	_	_
12	myristate	myristate	NN	NN	_	13	compound	_	_
13	acetate	acetate	NN	NN	_	7	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PMA	pma	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	plus	plus	CC	CC	_	13	cc	_	_
18	anti-CD28	anti-cd28	NN	NN	_	13	conj	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	induce	induce	VB	VB	_	0	root	_	_
22	NFATc	nfatc	NN	NN	_	21	dobj	_	_
23	,	,	,	,	_	21	punct	_	_
24	indicating	indicate	VBG	VBG	_	21	advcl	_	_
25	that	that	IN	IN	_	37	mark	_	_
26	under	under	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	conditions	condition	NNS	NNS	_	37	nmod	_	_
29	,	,	,	,	_	37	punct	_	_
30	interleukin-2	interleukin-2	NN	NN	_	31	compound	_	_
31	synthesis	synthesis	NN	NN	_	37	nsubj	_	_
32	by	by	IN	IN	_	34	case	_	_
33	these	these	DT	DT	_	34	det	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	is	be	VBZ	VBZ	_	37	cop	_	_
36	apparently	apparently	RB	RB	_	37	advmod	_	_
37	independent	independent	JJ	JJ	_	24	ccomp	_	_
38	of	of	IN	IN	_	39	case	_	_
39	NFATc	nfatc	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	PMA	pma	NN	NN	_	14	nsubj	_	_
8	plus	plus	CC	CC	_	7	cc	_	_
9	anti-CD28	anti-cd28	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	PMA	pma	NN	NN	_	7	conj	_	_
12	plus	plus	CC	CC	_	11	cc	_	_
13	ionomycin	ionomycin	NN	NN	_	11	conj	_	_
14	resulted	result	VBD	VBD	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	NFAT	nfat	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	PMA-ionomycin-induced	pma-ionomycin-induced	JJ	JJ	_	5	amod	_	_
5	synthesis	synthesis	NN	NN	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NFATc	nfatc	NN	NN	_	5	nmod	_	_
8	that	that	WDT	WDT	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	5	acl:relcl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	immunoprecipitation	immunoprecipitation	NN	NN	_	10	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	mirrored	mirror	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	assays	assay	NNS	NNS	_	15	nmod	_	_
21	:	:	:	:	_	15	punct	_	_
22	nearly	nearly	RB	RB	_	23	advmod	_	_
23	all	all	DT	DT	_	28	nsubj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activity	activity	NN	NN	_	23	nmod	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	due	due	JJ	JJ	_	15	parataxis	_	_
29	to	to	TO	TO	_	30	case	_	_
30	NFATp	nfatp	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	study	study	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	expression	expression	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	all	all	DT	DT	_	11	det	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	7	nmod	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	level	level	NN	NN	_	7	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	normal	normal	JJ	JJ	_	20	amod	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	7	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	High	high	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	DNA-binding	dna-binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	E2F	e2f	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	adult	adult	JJ	JJ	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	leukemia	leukemia	NN	NN	_	2	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	human	human	JJ	JJ	_	20	amod	_	_
15	T-cell	t-cell	NN	NN	_	20	compound	_	_
16	leukemia	leukemia	NN	NN	_	20	compound	_	_
17	virus	virus	NN	NN	_	20	compound	_	_
18	type	type	NN	NN	_	20	compound	_	_
19	I-infected	i-infected	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	12	conj	_	_
21	:	:	:	:	_	2	punct	_	_
22	possible	possible	JJ	JJ	_	23	amod	_	_
23	enhancement	enhancement	NN	NN	_	2	dep	_	_
24	of	of	IN	IN	_	25	case	_	_
25	DNA-binding	dna-binding	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	E2F	e2f	NN	NN	_	25	nmod	_	_
28	by	by	IN	IN	_	36	case	_	_
29	the	the	DT	DT	_	36	det	_	_
30	human	human	JJ	JJ	_	36	amod	_	_
31	T-cell	t-cell	NN	NN	_	36	compound	_	_
32	leukemia	leukemia	NN	NN	_	36	compound	_	_
33	virus	virus	NN	NN	_	36	compound	_	_
34	I	i	CD	CD	_	36	nummod	_	_
35	transactivating	transactivating	NN	NN	_	36	compound	_	_
36	protein	protein	NN	NN	_	23	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	Tax	tax	NN	NN	_	36	appos	_	_
39	.	.	.	.	_	23	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	4	nsubj	_	_
3	E2F	e2f	NN	NN	_	2	dep	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	promoters	promoter	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	certain	certain	JJ	JJ	_	10	amod	_	_
10	growth-	growth-	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cell	cell	NN	NN	_	10	conj	_	_
13	cycle-controlling	cycle-controlling	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	10	dep	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	forms	form	VBZ	VBZ	_	4	conj	_	_
17	distinct	distinct	JJ	JJ	_	19	amod	_	_
18	heteromeric	heteromeric	JJ	JJ	_	19	amod	_	_
19	complexes	complex	NNS	NNS	_	16	dobj	_	_
20	with	with	IN	IN	_	23	case	_	_
21	other	other	JJ	JJ	_	23	amod	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	proteins	protein	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	proposed	propose	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	E2F	e2f	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	5	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	cellular	cellular	JJ	JJ	_	13	amod	_	_
12	proliferation	proliferation	NN	NN	_	13	compound	_	_
13	control	control	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	13	nsubj	_	_
6	I	i	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-I	htlv-i	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	an	a	DT	DT	_	13	det	_	_
12	etiological	etiological	JJ	JJ	_	13	amod	_	_
13	agent	agent	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	17	case	_	_
15	adult	adult	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ATL	atl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	mobility-shift	mobility-shift	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	2	nmod	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	E2F-containing	e2f-containing	JJ	JJ	_	10	amod	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	complexes	complex	NNS	NNS	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	2	ccomp	_	_
13	in	in	IN	IN	_	16	case	_	_
14	HTLV-I-infected	htlv-i-infected	JJ	JJ	_	16	amod	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	leukemic	leukemic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	conj	_	_
20	obtained	obtain	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	ATL	atl	NN	NN	_	23	compound	_	_
23	patients	patient	NNS	NNS	_	20	nmod	_	_
24	but	but	CC	CC	_	16	cc	_	_
25	not	not	RB	RB	_	30	neg	_	_
26	in	in	IN	IN	_	30	case	_	_
27	an	a	DT	DT	_	30	det	_	_
28	uninfected	uninfected	JJ	JJ	_	30	amod	_	_
29	T-cell	t-cell	NN	NN	_	30	compound	_	_
30	line	line	NN	NN	_	16	conj	_	_
31	,	,	,	,	_	30	punct	_	_
32	Jurkat	jurkat	NN	NN	_	30	appos	_	_
33	,	,	,	,	_	30	punct	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	normal	normal	JJ	JJ	_	39	amod	_	_
36	peripheral	peripheral	JJ	JJ	_	39	amod	_	_
37	blood	blood	NN	NN	_	39	compound	_	_
38	mononuclear	mononuclear	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	30	conj	_	_
40	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tax	tax	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	13	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	encoded	encode	VBN	VBN	_	3	acl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	HTLV-I	htlv-i	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	3	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	potent	potent	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	activator	activator	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	15	case	_	_
15	viral	viral	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	several	several	JJ	JJ	_	15	conj	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	15	dep	_	_
20	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	expression	expression	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Tax	tax	NN	NN	_	4	nmod	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	induce	induce	VB	VB	_	2	ccomp	_	_
9	the	the	DT	DT	_	12	det	_	_
10	E2F-containing	e2f-containing	JJ	JJ	_	12	amod	_	_
11	DNA-binding	dna-binding	JJ	JJ	_	12	amod	_	_
12	complexes	complex	NNS	NNS	_	8	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Jurkat	jurkat	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	Tax	tax	NN	NN	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	through	through	IN	IN	_	6	case	_	_
6	enhancement	enhancement	NN	NN	_	16	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	DNA-binding	dna-binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	E2F	e2f	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	capable	capable	JJ	JJ	_	0	root	_	_
17	of	of	IN	IN	_	18	mark	_	_
18	regulating	regulate	VBG	VBG	_	16	advcl	_	_
19	cellular	cellular	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	dobj	_	_
22	implicated	implicate	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	dep	_	_
25	proliferation	proliferation	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	transformation	transformation	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	ATL	atl	NN	NN	_	18	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	5	nsubj	_	_
3	may	may	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	cop	_	_
5	relevant	relevant	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanisms	mechanism	NNS	NNS	_	5	nmod	_	_
9	whereby	whereby	WRB	WRB	_	16	advmod	_	_
10	HTLV-I	htlv-i	NN	NN	_	16	nsubj	_	_
11	which	which	WDT	WDT	_	14	nsubj	_	_
12	does	do	VBZ	VBZ	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	contain	contain	VB	VB	_	10	acl:relcl	_	_
15	oncogenes	oncogene	NNS	NNS	_	14	dobj	_	_
16	induces	induce	VBZ	VBZ	_	8	acl:relcl	_	_
17	neoplasia	neoplasia	NN	NN	_	16	dobj	_	_
18	.	.	.	.	_	5	punct	_	_

1	Oncogenic	oncogenic	JJ	JJ	_	2	amod	_	_
2	forms	form	NNS	NNS	_	17	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NOTCH1	notch1	NN	NN	_	2	nmod	_	_
5	lacking	lack	VBG	VBG	_	2	acl	_	_
6	either	either	CC	CC	_	10	cc:preconj	_	_
7	the	the	DT	DT	_	10	det	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	binding	bind	VBG	VBG	_	10	amod	_	_
10	site	site	NN	NN	_	5	dobj	_	_
11	for	for	IN	IN	_	12	case	_	_
12	RBP-Jkappa	rbp-jkappa	NN	NN	_	10	nmod	_	_
13	or	or	CC	CC	_	10	cc	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	localization	localization	NN	NN	_	16	compound	_	_
16	sequences	sequence	NNS	NNS	_	10	conj	_	_
17	retain	retain	VBP	VBP	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ability	ability	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	associate	associate	VB	VB	_	19	acl	_	_
22	with	with	IN	IN	_	23	case	_	_
23	RBP-Jkappa	rbp-jkappa	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	activate	activate	VB	VB	_	21	conj	_	_
26	transcription	transcription	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	17	punct	_	_

1	Truncated	truncated	JJ	JJ	_	2	amod	_	_
2	forms	form	NNS	NNS	_	28	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	NOTCH1	notch1	NN	NN	_	7	compound	_	_
6	transmembrane	transmembrane	JJ	JJ	_	7	amod	_	_
7	receptor	receptor	NN	NN	_	2	nmod	_	_
8	engineered	engineer	VBN	VBN	_	2	acl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	resemble	resemble	VB	VB	_	8	xcomp	_	_
11	mutant	mutant	JJ	JJ	_	12	amod	_	_
12	forms	form	NNS	NNS	_	10	xcomp	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NOTCH1	notch1	NN	NN	_	12	nmod	_	_
15	found	find	VBN	VBN	_	12	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	certain	certain	JJ	JJ	_	18	amod	_	_
18	cases	case	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	leukemia/lymphoma	leukemia/lymphoma	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	T-ALL	t-all	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	efficiently	efficiently	RB	RB	_	28	advmod	_	_
28	induce	induce	VBP	VBP	_	0	root	_	_
29	T-ALL	t-all	NN	NN	_	28	dobj	_	_
30	when	when	WRB	WRB	_	31	advmod	_	_
31	expressed	express	VBN	VBN	_	28	advcl	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	bone	bone	NN	NN	_	35	compound	_	_
35	marrow	marrow	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	mice	mouse	NNS	NNS	_	35	nmod	_	_
38	.	.	.	.	_	28	punct	_	_

1	Unlike	unlike	IN	IN	_	3	case	_	_
2	full-sized	full-sized	JJ	JJ	_	3	amod	_	_
3	NOTCH1	notch1	NN	NN	_	35	nmod	_	_
4	,	,	,	,	_	35	punct	_	_
5	two	two	CD	CD	_	8	nummod	_	_
6	such	such	JJ	JJ	_	7	amod	_	_
7	truncated	truncated	JJ	JJ	_	8	amod	_	_
8	forms	form	NNS	NNS	_	35	nsubjpass	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	protein	protein	NN	NN	_	8	nmod	_	_
12	either	either	CC	CC	_	13	cc:preconj	_	_
13	lacking	lack	VBG	VBG	_	8	dep	_	_
14	a	a	DT	DT	_	16	det	_	_
15	major	major	JJ	JJ	_	16	amod	_	_
16	portion	portion	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	extracellular	extracellular	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	DeltaE	deltae	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	or	or	CC	CC	_	13	cc	_	_
25	consisting	consist	VBG	VBG	_	13	conj	_	_
26	only	only	RB	RB	_	30	advmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	intracellular	intracellular	JJ	JJ	_	30	amod	_	_
30	domain	domain	NN	NN	_	25	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	ICN	icn	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	were	be	VBD	VBD	_	35	auxpass	_	_
35	found	find	VBN	VBN	_	0	root	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	activate	activate	VB	VB	_	35	xcomp	_	_
38	transcription	transcription	NN	NN	_	37	dobj	_	_
39	in	in	IN	IN	_	41	case	_	_
40	cultured	culture	VBN	VBN	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	,	,	,	,	_	37	punct	_	_
43	presumably	presumably	RB	RB	_	47	advmod	_	_
44	through	through	IN	IN	_	47	case	_	_
45	RBP-Jkappa	rbp-jkappa	NN	NN	_	47	compound	_	_
46	response	response	NN	NN	_	47	compound	_	_
47	elements	element	NNS	NNS	_	37	nmod	_	_
48	within	within	IN	IN	_	49	case	_	_
49	DNA	dna	NN	NN	_	47	nmod	_	_
50	.	.	.	.	_	35	punct	_	_

1	Both	both	CC	CC	_	3	dep	_	_
2	truncated	truncated	JJ	JJ	_	3	dep	_	_
3	forms	form	NNS	NNS	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	RBP-Jkappa	rbp-jkappa	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	extracts	extract	NNS	NNS	_	10	nmod	_	_
13	prepared	prepare	VBN	VBN	_	12	acl	_	_
14	from	from	IN	IN	_	15	case	_	_
15	human	human	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	murine	murine	JJ	JJ	_	15	conj	_	_
18	T-ALL	t-all	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	15	dep	_	_
21	.	.	.	.	_	5	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	3	nsubj	_	_
3	required	require	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	weak	weak	JJ	JJ	_	10	amod	_	_
9	RBP-Jkappa-binding	rbp-jkappa-binding	JJ	JJ	_	10	amod	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	within	within	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	NOTCH1	notch1	NN	NN	_	16	compound	_	_
14	ankyrin	ankyrin	NN	NN	_	16	compound	_	_
15	repeat	repeat	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	5	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	30	advmod	_	_
2	,	,	,	,	_	30	punct	_	_
3	a	a	DT	DT	_	8	det	_	_
4	second	second	JJ	JJ	_	8	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	stronger	stronger	JJR	JJR	_	4	dep	_	_
7	RBP-Jkappa-binding	rbp-jkappa-binding	JJ	JJ	_	8	amod	_	_
8	site	site	NN	NN	_	30	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	lies	lie	VBZ	VBZ	_	8	acl:relcl	_	_
12	within	within	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	intracellular	intracellular	JJ	JJ	_	15	amod	_	_
15	domain	domain	NN	NN	_	11	nmod	_	_
16	close	close	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transmembrane	transmembrane	JJ	JJ	_	20	amod	_	_
20	region	region	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	augments	augment	VBZ	VBZ	_	11	conj	_	_
24	association	association	NN	NN	_	23	dobj	_	_
25	with	with	IN	IN	_	26	case	_	_
26	RBP-Jkappa	rbp-jkappa	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	8	punct	_	_
28	was	be	VBD	VBD	_	30	auxpass	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	needed	need	VBN	VBN	_	0	root	_	_
31	for	for	IN	IN	_	32	case	_	_
32	oncogenesis	oncogenesis	NN	NN	_	30	nmod	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	for	for	IN	IN	_	36	case	_	_
35	transcriptional	transcriptional	JJ	JJ	_	36	amod	_	_
36	activation	activation	NN	NN	_	32	conj	_	_
37	.	.	.	.	_	30	punct	_	_

1	While	while	IN	IN	_	3	mark	_	_
2	ICN	icn	NN	NN	_	3	nsubj	_	_
3	appeared	appear	VBD	VBD	_	10	advcl	_	_
4	primarily	primarily	RB	RB	_	7	advmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	nucleus	nucleus	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	DeltaE	deltae	NN	NN	_	10	nsubj	_	_
10	localized	localize	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	cytoplasmic	cytoplasmic	JJ	JJ	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	nuclear	nuclear	JJ	JJ	_	12	conj	_	_
15	membranes	membrane	NNS	NNS	_	12	dep	_	_
16	,	,	,	,	_	10	punct	_	_
17	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	intranuclear	intranuclear	JJ	JJ	_	20	amod	_	_
20	localization	localization	NN	NN	_	23	nsubj	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	essential	essential	JJ	JJ	_	17	ccomp	_	_
24	for	for	IN	IN	_	25	case	_	_
25	oncogenesis	oncogenesis	NN	NN	_	23	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	activation	activation	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	support	support	NN	NN	_	13	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	interpretation	interpretation	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	mutation	mutation	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	putative	putative	JJ	JJ	_	12	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	localization	localization	NN	NN	_	12	compound	_	_
12	sequences	sequence	NNS	NNS	_	7	nmod	_	_
13	decreased	decrease	VBD	VBD	_	0	root	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	localization	localization	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	increased	increase	VBD	VBD	_	13	conj	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	17	dobj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	membrane-bound	membrane-bound	JJ	JJ	_	22	amod	_	_
22	DeltaE	deltae	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	12	nsubj	_	_
3	by	by	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	mutant	mutant	JJ	JJ	_	6	amod	_	_
6	form	form	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	membrane-bound	membrane-bound	JJ	JJ	_	9	amod	_	_
9	DeltaE	deltae	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	approximately	approximately	RB	RB	_	12	advmod	_	_
12	equivalent	equivalent	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	that	that	DT	DT	_	12	nmod	_	_
15	produced	produce	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	intranuclear	intranuclear	JJ	JJ	_	18	amod	_	_
18	ICN	icn	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	consistent	consistent	JJ	JJ	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	NOTCH1	notch1	NN	NN	_	8	compound	_	_
8	oncogenesis	oncogenesis	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	13	nsubj	_	_
12	being	be	VBG	VBG	_	13	cop	_	_
13	independent	independent	JJ	JJ	_	5	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	association	association	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	RBP-Jkappa	rbp-jkappa	NN	NN	_	15	nmod	_	_
18	at	at	IN	IN	_	20	case	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	pathway	pathway	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	inflammatory	inflammatory	JJ	JJ	_	8	amod	_	_
8	stimuli	stimulus	NNS	NNS	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	neutrophils	neutrophil	NNS	NNS	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Activated	activate	VBN	VBN	_	2	amod	_	_
2	neutrophils	neutrophil	NNS	NNS	_	3	nsubj	_	_
3	have	have	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ability	ability	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	upregulate	upregulate	VB	VB	_	5	dep	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	many	many	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	in	in	IN	IN	_	15	case	_	_
15	particular	particular	JJ	JJ	_	12	nmod	_	_
16	those	those	DT	DT	_	12	dep	_	_
17	encoding	encode	VBG	VBG	_	16	acl	_	_
18	cytokines	cytokine	NNS	NNS	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	chemokines	chemokine	NNS	NNS	_	18	conj	_	_
21	,	,	,	,	_	7	punct	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	subsequently	subsequently	RB	RB	_	25	advmod	_	_
25	release	release	VB	VB	_	7	conj	_	_
26	the	the	DT	DT	_	28	det	_	_
27	corresponding	corresponding	JJ	JJ	_	28	amod	_	_
28	proteins	protein	NNS	NNS	_	25	dobj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	little	little	JJ	JJ	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	known	know	VBN	VBN	_	18	advcl	_	_
5	to	to	TO	TO	_	6	case	_	_
6	date	date	NN	NN	_	4	nmod	_	_
7	concerning	concern	VBG	VBG	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	it	it	PRP	PRP	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	noteworthy	noteworthy	JJ	JJ	_	0	root	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	many	many	JJ	JJ	_	24	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	genes	gene	NNS	NNS	_	20	nmod	_	_
24	depend	depend	VBP	VBP	_	18	ccomp	_	_
25	on	on	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	27	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	such	such	JJ	JJ	_	34	case	_	_
33	as	as	IN	IN	_	32	mwe	_	_
34	NF-kappaB	nf-kappab	NN	NN	_	30	nmod	_	_
35	,	,	,	,	_	24	punct	_	_
36	for	for	IN	IN	_	38	case	_	_
37	inducible	inducible	JJ	JJ	_	38	amod	_	_
38	expression	expression	NN	NN	_	24	nmod	_	_
39	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	8	mark	_	_
5	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	3	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	neutrophils	neutrophil	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	as	as	RB	RB	_	8	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	fate	fate	NN	NN	_	8	conj	_	_
18	on	on	IN	IN	_	20	case	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	dimers	dimer	NNS	NNS	_	17	nsubj	_	_
6	consisting	consist	VBG	VBG	_	5	acl	_	_
7	of	of	IN	IN	_	9	case	_	_
8	p50	p50	NN	NN	_	9	compound	_	_
9	NFkappaB1	nfkappab1	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	p65	p65	NN	NN	_	12	compound	_	_
12	RelA	rela	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	and/or	and/or	CC	CC	_	9	cc	_	_
15	c-Rel	c-rel	NN	NN	_	9	conj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	present	present	JJ	JJ	_	3	ccomp	_	_
18	in	in	IN	IN	_	19	case	_	_
19	neutrophils	neutrophil	NNS	NNS	_	17	nmod	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	that	that	IN	IN	_	31	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	greater	greater	JJR	JJR	_	24	amod	_	_
24	part	part	NN	NN	_	31	nsubjpass	_	_
25	of	of	IN	IN	_	28	case	_	_
26	these	these	DT	DT	_	28	det	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	complexes	complex	NNS	NNS	_	24	nmod	_	_
29	is	be	VBZ	VBZ	_	31	auxpass	_	_
30	physically	physically	RB	RB	_	31	advmod	_	_
31	associated	associate	VBN	VBN	_	17	conj	_	_
32	with	with	IN	IN	_	34	case	_	_
33	cytoplasmic	cytoplasmic	JJ	JJ	_	34	amod	_	_
34	IkappaB-alpha	ikappab-alpha	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	resting	rest	VBG	VBG	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Following	follow	VBG	VBG	_	3	case	_	_
2	neutrophil	neutrophil	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	39	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	proinflammatory	proinflammatory	JJ	JJ	_	6	amod	_	_
6	agonists	agonist	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	such	such	JJ	JJ	_	10	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nmod	_	_
11	-LSB-	-lsb-	-LRB-	-LRB-	_	12	punct	_	_
12	LPS	lps	NN	NN	_	10	appos	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	10	punct	_	_
15	tumor	tumor	NN	NN	_	17	compound	_	_
16	necrosis	necrosis	NN	NN	_	17	compound	_	_
17	factor-alpha	factor-alpha	NN	NN	_	10	conj	_	_
18	-LSB-	-lsb-	-LRB-	-LRB-	_	19	punct	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	17	appos	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	10	punct	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	fMet-Leu-Phe	fmet-leu-phe	NN	NN	_	10	conj	_	_
24	)	)	-RRB-	-RRB-	_	10	punct	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	induce	induce	VBP	VBP	_	6	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	production	production	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	cytokines	cytokine	NNS	NNS	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	chemokines	chemokine	NNS	NNS	_	30	conj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	these	these	DT	DT	_	35	det	_	_
35	cells	cell	NNS	NNS	_	26	nmod	_	_
36	,	,	,	,	_	39	punct	_	_
37	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	38	compound	_	_
38	proteins	protein	NNS	NNS	_	39	nsubj	_	_
39	translocated	translocate	VBD	VBD	_	0	root	_	_
40	to	to	TO	TO	_	42	case	_	_
41	nuclear	nuclear	JJ	JJ	_	42	amod	_	_
42	fractions	fraction	NNS	NNS	_	39	nmod	_	_
43	,	,	,	,	_	39	punct	_	_
44	resulting	result	VBG	VBG	_	39	xcomp	_	_
45	in	in	IN	IN	_	48	case	_	_
46	a	a	DT	DT	_	48	det	_	_
47	transient	transient	JJ	JJ	_	48	amod	_	_
48	induction	induction	NN	NN	_	44	nmod	_	_
49	of	of	IN	IN	_	53	case	_	_
50	NF-kappaB	nf-kappab	NN	NN	_	53	compound	_	_
51	DNA	dna	NN	NN	_	53	compound	_	_
52	binding	binding	NN	NN	_	53	compound	_	_
53	activity	activity	NN	NN	_	48	nmod	_	_
54	,	,	,	,	_	44	punct	_	_
55	as	as	IN	IN	_	56	mark	_	_
56	determined	determine	VBN	VBN	_	44	advcl	_	_
57	in	in	IN	IN	_	61	case	_	_
58	gel	gel	NN	NN	_	61	compound	_	_
59	mobility	mobility	NN	NN	_	61	compound	_	_
60	shift	shift	NN	NN	_	61	compound	_	_
61	assays	assay	NNS	NNS	_	56	nmod	_	_
62	.	.	.	.	_	39	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	onset	onset	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	DT	DT	_	5	det	_	_
5	processes	process	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	11	mark	_	_
9	be	be	VB	VB	_	11	cop	_	_
10	closely	closely	RB	RB	_	11	advmod	_	_
11	paralleled	parallel	VBN	VBN	_	7	xcomp	_	_
12	by	by	IN	IN	_	11	nmod	_	_
13	,	,	,	,	_	11	punct	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	dependent	dependent	JJ	JJ	_	11	conj	_	_
16	on	on	IN	IN	_	15	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	IkappaB-alpha	ikappab-alpha	NN	NN	_	19	compound	_	_
19	degradation	degradation	NN	NN	_	11	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Proinflammatory	proinflammatory	JJ	JJ	_	2	amod	_	_
2	neutrophil	neutrophil	NN	NN	_	3	compound	_	_
3	stimuli	stimulus	NNS	NNS	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	promoted	promote	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	accumulation	accumulation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	IkappaB-alpha	ikappab-alpha	NN	NN	_	11	compound	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	transcripts	transcript	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	resulting	result	VBG	VBG	_	5	advcl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	reexpression	reexpression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IkappaB-alpha	ikappab-alpha	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	3	case	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	knowledge	knowledge	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	this	this	DT	DT	_	6	nsubj	_	_
6	constitutes	constitute	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	first	first	JJ	JJ	_	9	amod	_	_
9	indication	indication	NN	NN	_	6	dobj	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	underlie	underlie	VB	VB	_	9	ccomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	action	action	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	proinflammatory	proinflammatory	JJ	JJ	_	19	amod	_	_
19	stimuli	stimulus	NNS	NNS	_	16	nmod	_	_
20	towards	towards	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	neutrophil	neutrophil	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	16	nmod	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	,	,	,	,	_	14	punct	_	_
27	as	as	IN	IN	_	28	mark	_	_
28	such	such	JJ	JJ	_	14	advcl	_	_
29	,	,	,	,	_	14	punct	_	_
30	adds	add	VBZ	VBZ	_	14	dep	_	_
31	a	a	DT	DT	_	33	det	_	_
32	new	new	JJ	JJ	_	33	amod	_	_
33	facet	facet	NN	NN	_	30	dobj	_	_
34	to	to	TO	TO	_	36	case	_	_
35	our	we	PRP$	PRP$	_	36	nmod:poss	_	_
36	understanding	understanding	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	neutrophil	neutrophil	NN	NN	_	39	compound	_	_
39	biology	biology	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	Glucocorticoid-resistance	glucocorticoid-resistance	NN	NN	_	7	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	peripheral-blood	peripheral-blood	JJ	JJ	_	4	amod	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	does	do	VBZ	VBZ	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	correlate	correlate	VB	VB	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	number	number	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	affinity	affinity	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	glucocorticoid-receptors	glucocorticoid-receptor	NNS	NNS	_	11	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	chronic	chronic	JJ	JJ	_	18	amod	_	_
16	renal	renal	JJ	JJ	_	18	amod	_	_
17	failure	failure	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	GC	gc	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	resistance	resistance	NN	NN	_	16	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	chronic	chronic	JJ	JJ	_	11	amod	_	_
10	renal	renal	JJ	JJ	_	11	amod	_	_
11	failure	failure	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	CRF	crf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	seriously	seriously	RB	RB	_	16	advmod	_	_
16	impairs	impair	VBZ	VBZ	_	0	root	_	_
17	successive	successive	JJ	JJ	_	19	amod	_	_
18	GC	gc	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	16	dobj	_	_
20	after	after	IN	IN	_	22	case	_	_
21	renal	renal	JJ	JJ	_	22	amod	_	_
22	transplantation	transplantation	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	relationship	relationship	NN	NN	_	2	dobj	_	_
5	between	between	IN	IN	_	10	case	_	_
6	GC-receptor	gc-receptor	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	GC-R	gc-r	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	parameters	parameter	NNS	NNS	_	4	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	peripheral-blood	peripheral-blood	JJ	JJ	_	14	amod	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PBMC	pbmc	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	PBMC	pbmc	NN	NN	_	20	compound	_	_
20	resistance	resistance	NN	NN	_	10	conj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	GC	gc	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	21	21	CD	CD	_	26	nummod	_	_
25	CRF	crf	NN	NN	_	26	compound	_	_
26	patients	patient	NNS	NNS	_	2	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	18	18	CD	CD	_	30	nummod	_	_
29	healthy	healthy	JJ	JJ	_	30	amod	_	_
30	subjects	subject	NNS	NNS	_	26	conj	_	_
31	.	.	.	.	_	2	punct	_	_

1	Each	each	DT	DT	_	3	det	_	_
2	subject	subject	NN	NN	_	3	compound	_	_
3	group	group	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	divided	divide	VBN	VBN	_	0	root	_	_
6	into	into	IN	IN	_	8	case	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	subgroups	subgroup	NNS	NNS	_	5	nmod	_	_
9	according	accord	VBG	VBG	_	12	case	_	_
10	to	to	TO	TO	_	9	mwe	_	_
11	PBMC	pbmc	NN	NN	_	12	compound	_	_
12	sensitivity	sensitivity	NN	NN	_	8	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	prednisolone	prednisolone	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	mitogen	mitogen	NN	NN	_	19	compound	_	_
18	assay	assay	NN	NN	_	19	compound	_	_
19	procedure	procedure	NN	NN	_	12	nmod	_	_
20	;	;	:	:	_	5	punct	_	_
21	i.e.	i.e.	FW	FW	_	5	advcl	_	_
22	,	,	,	,	_	5	punct	_	_
23	sensitive	sensitive	JJ	JJ	_	5	dep	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	IC50	ic50	NN	NN	_	23	dep	_	_
26	&lt;	&lt;	JJR	JJR	_	25	amod	_	_
27	381	381	CD	CD	_	28	nummod	_	_
28	ng/mL	ng/ml	NN	NN	_	26	dep	_	_
29	)	)	-RRB-	-RRB-	_	25	punct	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	resistant	resistant	JJ	JJ	_	23	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	IC50	ic50	NN	NN	_	31	dep	_	_
34	&gt;	&gt;	JJR	JJR	_	33	amod	_	_
35	381	381	CD	CD	_	36	nummod	_	_
36	ng/mL	ng/ml	NN	NN	_	34	dep	_	_
37	)	)	-RRB-	-RRB-	_	33	punct	_	_
38	groups	group	NNS	NNS	_	23	dep	_	_
39	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	healthy	healthy	JJ	JJ	_	3	amod	_	_
3	subjects	subject	NNS	NNS	_	23	nmod	_	_
4	,	,	,	,	_	23	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mean	mean	NN	NN	_	23	nsubj	_	_
7	GC-R	gc-r	NN	NN	_	6	dep	_	_
8	Bmax	bmax	NN	NN	_	6	dep	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	Kd	kd	NN	NN	_	6	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	quiescent	quiescent	JJ	JJ	_	13	amod	_	_
13	PBMC	pbmc	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	GC-sensitive	gc-sensitive	JJ	JJ	_	17	amod	_	_
17	group	group	NN	NN	_	13	nmod	_	_
18	were	be	VBD	VBD	_	23	cop	_	_
19	2.89	2.89	CD	CD	_	23	nummod	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	1.23	1.23	CD	CD	_	19	conj	_	_
22	fmol/10(6)	fmol/10(6)	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	0	root	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	4.00	4.00	CD	CD	_	28	nummod	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	2.24	2.24	CD	CD	_	25	conj	_	_
28	nM	nm	NN	NN	_	23	conj	_	_
29	,	,	,	,	_	23	punct	_	_
30	respectively	respectively	RB	RB	_	23	advmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	Bmax	bmax	NN	NN	_	7	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	subjects	subject	NNS	NNS	_	2	nmod	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	case	_	_
9	6.61	6.61	CD	CD	_	7	nmod	_	_
10	+/-	+/-	CC	CC	_	9	cc	_	_
11	2.02	2.02	CD	CD	_	9	conj	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	257.7	257.7	CD	CD	_	16	nummod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	107.8	107.8	CD	CD	_	13	conj	_	_
16	%	%	NN	NN	_	9	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	after	after	IN	IN	_	21	case	_	_
19	24	24	CD	CD	_	20	compound	_	_
20	h	h	NN	NN	_	21	amod	_	_
21	stimulation	stimulation	NN	NN	_	7	nmod	_	_
22	with	with	IN	IN	_	24	case	_	_
23	concanavalin	concanavalin	NN	NN	_	24	compound	_	_
24	A	a	NN	NN	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	p	p	NN	NN	_	21	dep	_	_
27	&lt;	&lt;	JJR	JJR	_	26	amod	_	_
28	0.01	0.01	CD	CD	_	27	dep	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	,	,	,	,	_	7	punct	_	_
31	while	while	IN	IN	_	37	mark	_	_
32	the	the	DT	DT	_	34	det	_	_
33	Kd	kd	NN	NN	_	34	compound	_	_
34	change	change	NN	NN	_	37	nsubj	_	_
35	was	be	VBD	VBD	_	37	cop	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	significant	significant	JJ	JJ	_	7	advcl	_	_
38	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	GC-R	gc-r	NN	NN	_	18	nsubj	_	_
3	Bmax	bmax	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Kd	kd	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	quiescent	quiescent	JJ	JJ	_	8	amod	_	_
8	PBMC	pbmc	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	GC-resistant	gc-resistant	JJ	JJ	_	12	amod	_	_
12	group	group	NN	NN	_	8	nmod	_	_
13	were	be	VBD	VBD	_	18	cop	_	_
14	5.33	5.33	CD	CD	_	18	nummod	_	_
15	+/-	+/-	CC	CC	_	14	cc	_	_
16	1.37	1.37	CD	CD	_	14	conj	_	_
17	fmol/10(6)	fmol/10(6)	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	0	root	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	3.20	3.20	CD	CD	_	23	nummod	_	_
21	+/-	+/-	CC	CC	_	20	cc	_	_
22	1.39	1.39	CD	CD	_	20	conj	_	_
23	nM	nm	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	18	punct	_	_
25	respectively	respectively	RB	RB	_	18	advmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	Both	both	DT	DT	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	parameters	parameter	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	however	however	RB	RB	_	10	advmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	change	change	VB	VB	_	0	root	_	_
11	significantly	significantly	RB	RB	_	10	advmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	mitogen	mitogen	NN	NN	_	14	compound	_	_
14	stimulation	stimulation	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	significant	significant	JJ	JJ	_	6	amod	_	_
5	negative	negative	JJ	JJ	_	4	dep	_	_
6	correlation	correlation	NN	NN	_	2	nsubj	_	_
7	between	between	IN	IN	_	8	case	_	_
8	IC50S	ic50s	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	prednisolone	prednisolone	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	increase-ratios	increase-ratios	NN	NN	_	8	conj	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	post/pre	post/pre	JJ	JJ	_	15	amod	_	_
15	ratio	ratio	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Bmax	bmax	NN	NN	_	12	nmod	_	_
19	after	after	IN	IN	_	21	case	_	_
20	mitogen	mitogen	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	2	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	p	p	NN	NN	_	21	dep	_	_
24	&lt;	&lt;	JJR	JJR	_	23	amod	_	_
25	0.05	0.05	CD	CD	_	24	dep	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	CRF	crf	NN	NN	_	3	compound	_	_
3	patients	patient	NNS	NNS	_	20	nmod	_	_
4	,	,	,	,	_	20	punct	_	_
5	Bmax	bmax	NN	NN	_	20	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Kd	kd	NN	NN	_	5	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	quiescent	quiescent	JJ	JJ	_	10	amod	_	_
10	PBMC	pbmc	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GC-sensitive	gc-sensitive	JJ	JJ	_	14	amod	_	_
14	group	group	NN	NN	_	10	nmod	_	_
15	were	be	VBD	VBD	_	20	cop	_	_
16	6.04	6.04	CD	CD	_	20	nummod	_	_
17	+/-	+/-	CC	CC	_	16	cc	_	_
18	2.35	2.35	CD	CD	_	16	conj	_	_
19	fmol/10(6)	fmol/10(6)	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	0	root	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	3.49	3.49	CD	CD	_	25	nummod	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	1.72	1.72	CD	CD	_	22	conj	_	_
25	nM	nm	NN	NN	_	20	conj	_	_
26	,	,	,	,	_	20	punct	_	_
27	respectively	respectively	RB	RB	_	20	advmod	_	_
28	,	,	,	,	_	20	punct	_	_
29	while	while	IN	IN	_	42	mark	_	_
30	those	those	DT	DT	_	42	nsubj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	PBMC	pbmc	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	GC-resistant	gc-resistant	JJ	JJ	_	36	amod	_	_
36	group	group	NN	NN	_	32	nmod	_	_
37	were	be	VBD	VBD	_	42	cop	_	_
38	5.13	5.13	CD	CD	_	42	nummod	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	2.31	2.31	CD	CD	_	38	conj	_	_
41	fmol/10(6)	fmol/10(6)	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	20	advcl	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	4.04	4.04	CD	CD	_	47	nummod	_	_
45	+/-	+/-	CC	CC	_	44	cc	_	_
46	1.62	1.62	CD	CD	_	44	conj	_	_
47	nM	nm	NN	NN	_	42	conj	_	_
48	,	,	,	,	_	42	punct	_	_
49	respectively	respectively	RB	RB	_	42	advmod	_	_
50	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	Bmax	bmax	NN	NN	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Kd	kd	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	8	auxpass	_	_
6	not	not	RB	RB	_	8	neg	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	changed	change	VBN	VBN	_	0	root	_	_
9	after	after	IN	IN	_	11	case	_	_
10	mitogen	mitogen	NN	NN	_	11	compound	_	_
11	stimulation	stimulation	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	both	both	DT	DT	_	14	det	_	_
14	subgroups	subgroup	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	CRF	crf	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	in	in	IN	IN	_	4	case	_	_
4	contrast	contrast	NN	NN	_	10	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	healthy	healthy	JJ	JJ	_	7	amod	_	_
7	subjects	subject	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	there	there	EX	EX	_	10	expl	_	_
10	was	be	VBD	VBD	_	0	root	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	correlation	correlation	NN	NN	_	10	nsubj	_	_
13	between	between	IN	IN	_	14	case	_	_
14	IC50	ic50	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	GC-R	gc-r	NN	NN	_	17	compound	_	_
17	parameters	parameter	NNS	NNS	_	14	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	CRF	crf	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	concluded	conclude	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	21	mark	_	_
4	,	,	,	,	_	21	punct	_	_
5	in	in	IN	IN	_	7	case	_	_
6	healthy	healthy	JJ	JJ	_	7	amod	_	_
7	subjects	subject	NNS	NNS	_	21	nmod	_	_
8	,	,	,	,	_	21	punct	_	_
9	decreased	decrease	VBN	VBN	_	11	amod	_	_
10	PBMC	pbmc	NN	NN	_	11	compound	_	_
11	capacity	capacity	NN	NN	_	21	nsubjpass	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	amplify	amplify	VB	VB	_	11	acl	_	_
14	GC-R	gc-r	NN	NN	_	15	compound	_	_
15	numbers	number	NNS	NNS	_	13	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	response	response	NN	NN	_	13	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	mitogen	mitogen	NN	NN	_	17	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	correlated	correlate	VBN	VBN	_	2	ccomp	_	_
22	with	with	IN	IN	_	24	case	_	_
23	GC	gc	NN	NN	_	24	compound	_	_
24	resistance	resistance	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	whereas	whereas	IN	IN	_	35	mark	_	_
27	in	in	IN	IN	_	29	case	_	_
28	CRF	crf	NN	NN	_	29	compound	_	_
29	patients	patient	NNS	NNS	_	35	nmod	_	_
30	the	the	DT	DT	_	32	det	_	_
31	resistant	resistant	JJ	JJ	_	32	amod	_	_
32	mechanism	mechanism	NN	NN	_	35	nsubjpass	_	_
33	is	be	VBZ	VBZ	_	35	auxpass	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	correlated	correlate	VBN	VBN	_	21	advcl	_	_
36	with	with	IN	IN	_	38	case	_	_
37	GC-R	gc-r	NN	NN	_	38	compound	_	_
38	parameters	parameter	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	unknown	unknown	JJ	JJ	_	3	amod	_	_
3	event	event	NN	NN	_	6	nsubjpass	_	_
4	might	might	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	involved	involve	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	GC-resistance	gc-resistance	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CRF	crf	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Significance	significance	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	quantitative	quantitative	JJ	JJ	_	4	amod	_	_
4	analysis	analysis	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	AML1/ETO	aml1/eto	NN	NN	_	7	compound	_	_
7	transcripts	transcript	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	stem	stem	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	from	from	IN	IN	_	17	case	_	_
14	t(8;21)	t(8;21)	NN	NN	_	17	compound	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	myelogenous	myelogenous	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Autologous	autologous	JJ	JJ	_	6	amod	_	_
2	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
3	blood	blood	NN	NN	_	5	compound	_	_
4	stem	stem	NN	NN	_	5	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	transplantation	transplantation	NN	NN	_	11	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PBSCT	pbsct	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	aux	_	_
11	replacing	replace	VBG	VBG	_	0	root	_	_
12	autologous	autologous	JJ	JJ	_	15	amod	_	_
13	bone	bone	NN	NN	_	15	compound	_	_
14	marrow	marrow	NN	NN	_	15	compound	_	_
15	transplantation	transplantation	NN	NN	_	11	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	BMT	bmt	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	treatment	treatment	NN	NN	_	11	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	leukemia	leukemia	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	One	one	CD	CD	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	potential	potential	JJ	JJ	_	5	amod	_	_
5	advantages	advantage	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	autologous	autologous	JJ	JJ	_	8	amod	_	_
8	PBSCT	pbsct	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	the	the	DT	DT	_	11	det	_	_
11	possibility	possibility	NN	NN	_	0	root	_	_
12	that	that	IN	IN	_	22	mark	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	stem	stem	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	22	nsubj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PBSC	pbsc	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	are	be	VBP	VBP	_	22	cop	_	_
21	less	less	RBR	RBR	_	22	advmod	_	_
22	likely	likely	JJ	JJ	_	11	ccomp	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	contaminated	contaminate	VBN	VBN	_	22	xcomp	_	_
26	by	by	IN	IN	_	28	case	_	_
27	leukemic	leukemic	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	than	than	IN	IN	_	32	mark	_	_
30	bone	bone	NN	NN	_	32	compound	_	_
31	marrow	marrow	NN	NN	_	32	compound	_	_
32	grafts	graft	NNS	NNS	_	22	ccomp	_	_
33	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	major	major	JJ	JJ	_	5	amod	_	_
5	problem	problem	NN	NN	_	7	nsubj	_	_
6	still	still	RB	RB	_	7	advmod	_	_
7	remains	remain	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	high	high	JJ	JJ	_	10	amod	_	_
10	incidence	incidence	NN	NN	_	7	xcomp	_	_
11	of	of	IN	IN	_	13	case	_	_
12	leukemic	leukemic	JJ	JJ	_	13	amod	_	_
13	relapse	relapse	NN	NN	_	10	nmod	_	_
14	following	follow	VBG	VBG	_	16	case	_	_
15	autologous	autologous	JJ	JJ	_	16	amod	_	_
16	PBSCT	pbsct	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	which	which	WDT	WDT	_	21	nsubjpass	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	caused	cause	VBN	VBN	_	13	acl:relcl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	reinfusion	reinfusion	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	PBSC	pbsc	NNS	NNS	_	24	nmod	_	_
27	contaminated	contaminate	VBN	VBN	_	26	acl	_	_
28	by	by	IN	IN	_	30	case	_	_
29	leukemic	leukemic	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	developed	develop	VBN	VBN	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	quantitative	quantitative	JJ	JJ	_	8	amod	_	_
8	assay	assay	NN	NN	_	5	dobj	_	_
9	using	use	VBG	VBG	_	8	acl	_	_
10	competitive	competitive	JJ	JJ	_	15	amod	_	_
11	reverse	reverse	JJ	JJ	_	13	amod	_	_
12	transcriptase	transcriptase	NN	NN	_	13	compound	_	_
13	polymerase	polymerase	NN	NN	_	15	compound	_	_
14	chain	chain	NN	NN	_	15	compound	_	_
15	reaction	reaction	NN	NN	_	9	dobj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	estimates	estimate	VBZ	VBZ	_	15	acl:relcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	number	number	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	AML1/ETO	aml1/eto	NN	NN	_	22	compound	_	_
22	transcripts	transcript	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	t(8;21)	t(8;21)	NN	NN	_	19	nmod	_	_
25	acute	acute	JJ	JJ	_	27	amod	_	_
26	myelogenous	myelogenous	JJ	JJ	_	27	amod	_	_
27	leukemia	leukemia	NN	NN	_	24	dep	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	AML	aml	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	5	punct	_	_
32	in	in	IN	IN	_	35	mark	_	_
33	order	order	NN	NN	_	32	mwe	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	determine	determine	VB	VB	_	5	advcl	_	_
36	the	the	DT	DT	_	37	det	_	_
37	degree	degree	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	41	case	_	_
39	leukemic	leukemic	JJ	JJ	_	41	amod	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	contamination	contamination	NN	NN	_	37	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	PBSC	pbsc	NNS	NNS	_	44	compound	_	_
44	harvests	harvest	NNS	NNS	_	37	nmod	_	_
45	,	,	,	,	_	35	punct	_	_
46	and	and	CC	CC	_	35	cc	_	_
47	to	to	TO	TO	_	48	mark	_	_
48	monitor	monitor	VB	VB	_	35	conj	_	_
49	minimal	minimal	JJ	JJ	_	51	amod	_	_
50	residual	residual	JJ	JJ	_	51	amod	_	_
51	disease	disease	NN	NN	_	48	dobj	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	MRD	mrd	NN	NN	_	51	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	quantitatively	quantitatively	RB	RB	_	48	advmod	_	_
56	in	in	IN	IN	_	57	case	_	_
57	patients	patient	NNS	NNS	_	48	nmod	_	_
58	with	with	IN	IN	_	60	case	_	_
59	t(8;21)	t(8;21)	NN	NN	_	60	compound	_	_
60	AML	aml	NN	NN	_	57	nmod	_	_
61	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	24	mark	_	_
5	although	although	IN	IN	_	13	mark	_	_
6	PBSC	pbsc	NNS	NNS	_	7	compound	_	_
7	harvests	harvest	NNS	NNS	_	13	nsubjpass	_	_
8	collected	collect	VBN	VBN	_	7	acl	_	_
9	after	after	IN	IN	_	11	case	_	_
10	consolidation	consolidation	NN	NN	_	11	compound	_	_
11	chemotherapy	chemotherapy	NN	NN	_	8	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	contaminated	contaminate	VBN	VBN	_	24	advcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	24	punct	_	_
18	the	the	DT	DT	_	19	det	_	_
19	degree	degree	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	leukemic	leukemic	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	contamination	contamination	NN	NN	_	19	nmod	_	_
24	decreases	decrease	VBZ	VBZ	_	3	ccomp	_	_
25	with	with	IN	IN	_	27	case	_	_
26	repeated	repeated	JJ	JJ	_	27	amod	_	_
27	cycles	cycle	NNS	NNS	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	chemotherapy	chemotherapy	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	MRD	mrd	NN	NN	_	9	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	PBSC	pbsc	NNS	NNS	_	7	compound	_	_
7	harvests	harvest	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	less	less	JJR	JJR	_	0	root	_	_
10	than	than	IN	IN	_	15	case	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	corresponding	corresponding	JJ	JJ	_	15	amod	_	_
14	bone	bone	NN	NN	_	15	compound	_	_
15	marrow	marrow	NN	NN	_	9	nmod	_	_
16	obtained	obtain	VBN	VBN	_	15	acl	_	_
17	on	on	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	day	day	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	PBSC	pbsc	NNS	NNS	_	23	compound	_	_
23	collection	collection	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	6	mark	_	_
4	be	be	VB	VB	_	6	cop	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	relationship	relationship	NN	NN	_	2	nsubj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	AML1/ETO	aml1/eto	NN	NN	_	12	compound	_	_
12	transcripts	transcript	NNS	NNS	_	9	nmod	_	_
13	found	find	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	infused	infuse	VBN	VBN	_	18	amod	_	_
17	PBSC	pbsc	NNS	NNS	_	18	compound	_	_
18	harvests	harvest	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	incidence	incidence	NN	NN	_	9	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	leukemic	leukemic	JJ	JJ	_	24	amod	_	_
24	relapse	relapse	NN	NN	_	21	nmod	_	_
25	following	follow	VBG	VBG	_	27	case	_	_
26	autologous	autologous	JJ	JJ	_	27	amod	_	_
27	PBSCT	pbsct	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	our	we	PRP$	PRP$	_	30	nmod:poss	_	_
30	study	study	NN	NN	_	6	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	substantial	substantial	JJ	JJ	_	5	amod	_	_
5	decrease	decrease	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	AML1/ETO	aml1/eto	NN	NN	_	8	compound	_	_
8	transcripts	transcript	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	seen	see	VBN	VBN	_	0	root	_	_
11	following	follow	VBG	VBG	_	13	case	_	_
12	autologous	autologous	JJ	JJ	_	13	amod	_	_
13	PBSCT	pbsct	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	quantitative	quantitative	JJ	JJ	_	5	amod	_	_
5	analysis	analysis	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	AML1/ETO	aml1/eto	NN	NN	_	8	compound	_	_
8	transcripts	transcript	NNS	NNS	_	5	nmod	_	_
9	may	may	MD	MD	_	12	aux	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	clinically	clinically	RB	RB	_	12	advmod	_	_
12	useful	useful	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	t(8;21)	t(8;21)	NN	NN	_	17	compound	_	_
17	AML	aml	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	methylation	methylation	NN	NN	_	3	compound	_	_
3	changes	change	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	hematologic	hematologic	JJ	JJ	_	6	amod	_	_
6	malignancies	malignancy	NNS	NNS	_	3	nmod	_	_
7	:	:	:	:	_	3	punct	_	_
8	biologic	biologic	JJ	JJ	_	3	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	clinical	clinical	JJ	JJ	_	8	conj	_	_
11	implications	implication	NNS	NNS	_	8	dep	_	_
12	.	.	.	.	_	3	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	methylation	methylation	NN	NN	_	3	compound	_	_
3	changes	change	NNS	NNS	_	10	nsubj	_	_
4	are	be	VBP	VBP	_	10	cop	_	_
5	among	among	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	most	most	RBS	RBS	_	9	advmod	_	_
8	common	common	JJ	JJ	_	9	amod	_	_
9	detectable	detectable	JJ	JJ	_	10	amod	_	_
10	abnormalities	abnormality	NNS	NNS	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	neoplasia	neoplasia	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	Hypermethylation	hypermethylation	NN	NN	_	8	nsubj	_	_
2	within	within	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	promoters	promoter	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	selected	select	VBN	VBN	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	appears	appear	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	especially	especially	RB	RB	_	12	advmod	_	_
12	common	common	JJ	JJ	_	8	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	all	all	DT	DT	_	15	det	_	_
15	types	type	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	hematopoietic	hematopoietic	JJ	JJ	_	19	amod	_	_
19	neoplasms	neoplasm	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	and	and	CC	CC	_	8	cc	_	_
22	is	be	VBZ	VBZ	_	24	auxpass	_	_
23	usually	usually	RB	RB	_	24	advmod	_	_
24	associated	associate	VBN	VBN	_	8	conj	_	_
25	with	with	IN	IN	_	26	case	_	_
26	inactivation	inactivation	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	involved	involve	VBN	VBN	_	32	amod	_	_
30	gene	gene	NN	NN	_	32	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	s	s	NNS	NNS	_	26	nmod	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	8	punct	_	_

1	Such	such	JJ	JJ	_	3	amod	_	_
2	hypermethylation-associated	hypermethylation-associated	JJ	JJ	_	3	amod	_	_
3	silencing	silencing	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	several	several	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	9	nmod	_	_
13	regulating	regulate	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	growth	growth	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	differentiation	differentiation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	hematopoietic	hematopoietic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	including	include	VBG	VBG	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	estrogen	estrogen	NN	NN	_	29	compound	_	_
25	receptor	receptor	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	ER	er	NN	NN	_	29	compound	_	_
28	)	)	-RRB-	-RRB-	_	29	punct	_	_
29	gene	gene	NN	NN	_	20	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	P15	p15	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	P16	p16	NN	NN	_	29	conj	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	others	other	NNS	NNS	_	29	conj	_	_
36	.	.	.	.	_	9	punct	_	_

1	Hypermethylation	hypermethylation	NN	NN	_	8	nsubj	_	_
2	within	within	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	promoters	promoter	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	some	some	DT	DT	_	7	det	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	appear	appear	VBP	VBP	_	0	root	_	_
9	to	to	TO	TO	_	13	mark	_	_
10	be	be	VB	VB	_	13	cop	_	_
11	an	a	DT	DT	_	13	det	_	_
12	early	early	JJ	JJ	_	13	amod	_	_
13	event	event	NN	NN	_	8	xcomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	pathogenesis	pathogenesis	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	neoplasia	neoplasia	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	ER	er	NN	NN	_	18	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	P15	p15	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	,	,	,	,	_	8	punct	_	_
25	while	while	IN	IN	_	28	mark	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	28	nsubj	_	_
28	seem	seem	VBP	VBP	_	8	advcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	become	become	VB	VB	_	28	xcomp	_	_
31	methylated	methylate	VBN	VBN	_	30	xcomp	_	_
32	during	during	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	progression	progression	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	leukemias	leukemia	NNS	NNS	_	34	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	HIC1	hic1	NN	NN	_	36	dep	_	_
39	,	,	,	,	_	38	punct	_	_
40	c-abl	c-abl	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	38	punct	_	_
42	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	high	high	JJ	JJ	_	3	amod	_	_
3	prevalence	prevalence	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	methylation	methylation	NN	NN	_	3	nmod	_	_
7	suggests	suggest	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	this	this	DT	DT	_	11	det	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	abnormality	abnormality	NN	NN	_	14	nsubjpass	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	7	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	monitor	monitor	VB	VB	_	14	xcomp	_	_
17	disease	disease	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	during	during	IN	IN	_	20	case	_	_
20	therapy	therapy	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	technology	technology	NN	NN	_	6	nsubj	_	_
6	allows	allow	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	sensitive	sensitive	JJ	JJ	_	9	amod	_	_
9	identification	identification	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	hypermethylation	hypermethylation	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	background	background	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
21	possible	possible	JJ	JJ	_	23	amod	_	_
22	new	new	JJ	JJ	_	21	dep	_	_
23	strategies	strategy	NNS	NNS	_	20	dobj	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	detection	detection	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	minimal	minimal	JJ	JJ	_	30	amod	_	_
29	residual	residual	JJ	JJ	_	30	amod	_	_
30	disease	disease	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Finally	finally	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	reactivation	reactivation	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	tumor-suppressor	tumor-suppressor	JJ	JJ	_	7	amod	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	through	through	IN	IN	_	10	case	_	_
9	pharmacologic	pharmacologic	JJ	JJ	_	10	amod	_	_
10	inhibition	inhibition	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	methyltransferase	methyltransferase	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	resultant	resultant	JJ	JJ	_	17	amod	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	demethylation	demethylation	NN	NN	_	13	conj	_	_
18	appears	appear	VBZ	VBZ	_	0	root	_	_
19	to	to	TO	TO	_	24	mark	_	_
20	be	be	VB	VB	_	24	cop	_	_
21	a	a	DT	DT	_	24	det	_	_
22	promising	promising	JJ	JJ	_	24	amod	_	_
23	new	new	JJ	JJ	_	22	dep	_	_
24	avenue	avenue	NN	NN	_	18	xcomp	_	_
25	of	of	IN	IN	_	26	case	_	_
26	therapy	therapy	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	acute	acute	JJ	JJ	_	29	amod	_	_
29	leukemia	leukemia	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	collagenase-1	collagenase-1	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	11	case	_	_
6	differentiated	differentiate	VBN	VBN	_	11	amod	_	_
7	monocyte-like	monocyte-like	JJ	JJ	_	11	amod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	U937	u937	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	AP-1	ap-1	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	an	a	DT	DT	_	20	det	_	_
18	upstream	upstream	JJ	JJ	_	20	amod	_	_
19	C/EBP-beta	c/ebp-beta	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	16	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	a	a	DT	DT	_	15	det	_	_
13	distal	distal	JJ	JJ	_	15	amod	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	element	element	NN	NN	_	10	conj	_	_
16	regulate	regulate	VBP	VBP	_	6	ccomp	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	induction	induction	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	collagenase-1	collagenase-1	NN	NN	_	18	nmod	_	_
21	during	during	IN	IN	_	23	case	_	_
22	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Chloramphenicol	chloramphenicol	NN	NN	_	4	compound	_	_
2	acetyltransferase	acetyltransferase	NN	NN	_	4	compound	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	constructs	construct	NNS	NNS	_	16	nsubjpass	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	regions	region	NNS	NNS	_	5	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	collagenase-1	collagenase-1	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	6	nmod	_	_
12	were	be	VBD	VBD	_	16	auxpass	_	_
13	stably	stably	RB	RB	_	14	advmod	_	_
14	or	or	CC	CC	_	16	advmod	_	_
15	transiently	transiently	RB	RB	_	14	advmod	_	_
16	transfected	transfect	VBN	VBN	_	0	root	_	_
17	into	into	IN	IN	_	19	case	_	_
18	U937	u937	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	16	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	assessed	assess	VBN	VBN	_	16	conj	_	_
26	at	at	IN	IN	_	28	case	_	_
27	various	various	JJ	JJ	_	28	amod	_	_
28	times	time	NNS	NNS	_	25	nmod	_	_
29	after	after	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	onset	onset	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	40	case	_	_
33	phorbol	phorbol	NN	NN	_	40	compound	_	_
34	12-myristate	12-myristate	NN	NN	_	40	compound	_	_
35	13-acetate	13-acetate	NN	NN	_	40	compound	_	_
36	(	(	-LRB-	-LRB-	_	40	punct	_	_
37	PMA	pma	NN	NN	_	40	compound	_	_
38	)	)	-RRB-	-RRB-	_	40	punct	_	_
39	-mediated	-mediated	JJ	JJ	_	40	amod	_	_
40	differentiation	differentiation	NN	NN	_	31	nmod	_	_
41	.	.	.	.	_	16	punct	_	_

1	Rapid	rapid	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	strong	strong	JJ	JJ	_	1	conj	_	_
4	induction	induction	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	lost	lose	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	constructs	construct	NNS	NNS	_	9	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	mutant	mutant	JJ	JJ	_	16	amod	_	_
15	AP-1	ap-1	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	11	nmod	_	_
17	;	;	:	:	_	9	punct	_	_
18	however	however	RB	RB	_	29	advmod	_	_
19	,	,	,	,	_	29	punct	_	_
20	at	at	IN	IN	_	23	case	_	_
21	16-96	16-96	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	23	amod	_	_
23	post-PMA	post-pma	NN	NN	_	29	nmod	_	_
24	,	,	,	,	_	29	punct	_	_
25	the	the	DT	DT	_	28	det	_	_
26	mutant	mutant	JJ	JJ	_	28	amod	_	_
27	collagenase-1	collagenase-1	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	29	nsubj	_	_
29	displayed	display	VBD	VBD	_	9	parataxis	_	_
30	AP-1	ap-1	NN	NN	_	31	nmod:npmod	_	_
31	independent	independent	JJ	JJ	_	29	xcomp	_	_
32	PMA-mediated	pma-mediated	JJ	JJ	_	31	dep	_	_
33	transactivation	transactivation	NN	NN	_	29	dep	_	_
34	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	AP-1	ap-1	NN	NN	_	4	compound	_	_
3	mutant	mutant	JJ	JJ	_	4	amod	_	_
4	constructs	construct	NNS	NNS	_	6	nsubj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	delayed	delay	VBN	VBN	_	9	amod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	PMA-treated	pma-treated	JJ	JJ	_	12	amod	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Western	western	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	supershift	supershift	NN	NN	_	1	conj	_	_
4	analyses	analysis	NNS	NNS	_	1	dep	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	Jun	jun	NN	NN	_	13	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Fos	fos	NN	NN	_	8	conj	_	_
11	proteins	protein	NNS	NNS	_	8	dep	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	present	present	JJ	JJ	_	5	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	extracts	extract	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	PMA-differentiated	pma-differentiated	JJ	JJ	_	20	amod	_	_
19	U937	u937	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Promoter	promoter	NN	NN	_	3	compound	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	constructs	construct	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	potential	potential	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	distal	distal	JJ	JJ	_	11	amod	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	regulating	regulate	VBG	VBG	_	7	acl	_	_
14	collagenase-1	collagenase-1	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	Western	western	NN	NN	_	12	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	supershift	supershift	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	deletion	deletion	NN	NN	_	4	conj	_	_
11	analyses	analysis	NNS	NNS	_	4	dep	_	_
12	suggested	suggest	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	role	role	NN	NN	_	12	dobj	_	_
15	for	for	IN	IN	_	22	case	_	_
16	CCAAT/enhancer-binding	ccaat/enhancer-binding	JJ	JJ	_	22	amod	_	_
17	protein-beta	protein-beta	NN	NN	_	22	compound	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	C/EBP-beta	c/ebp-beta	NN	NN	_	22	compound	_	_
20	)	)	-RRB-	-RRB-	_	22	punct	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	14	nmod	_	_
23	between	between	IN	IN	_	24	case	_	_
24	-2010	-2010	CD	CD	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	-1954	-1954	CD	CD	_	24	conj	_	_
27	in	in	IN	IN	_	28	mark	_	_
28	regulating	regulate	VBG	VBG	_	14	acl	_	_
29	transcription	transcription	NN	NN	_	28	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	collagenase-1	collagenase-1	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	monocytic	monocytic	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	distinct	distinct	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	16	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	acting	act	VBG	VBG	_	7	acl	_	_
10	somewhat	somewhat	RB	RB	_	11	advmod	_	_
11	independently	independently	RB	RB	_	9	advmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	each	each	DT	DT	_	14	det	_	_
14	other	other	JJ	JJ	_	11	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	control	control	VBP	VBP	_	3	ccomp	_	_
17	expression	expression	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	collagenase-1	collagenase-1	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	rapid	rapid	JJ	JJ	_	11	amod	_	_
10	PMA-mediated	pma-mediated	JJ	JJ	_	9	dep	_	_
11	induction	induction	NN	NN	_	16	nsubjpass	_	_
12	of	of	IN	IN	_	14	case	_	_
13	collagenase-1	collagenase-1	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	controlled	control	VBN	VBN	_	6	ccomp	_	_
17	by	by	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	mechanism	mechanism	NN	NN	_	16	nmod	_	_
20	distinct	distinct	JJ	JJ	_	19	amod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	regulating	regulate	VBG	VBG	_	22	acl	_	_
24	the	the	DT	DT	_	26	det	_	_
25	sustained	sustained	JJ	JJ	_	26	amod	_	_
26	expression	expression	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	proteinase	proteinase	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	activated	activate	VBN	VBN	_	32	amod	_	_
32	macrophages	macrophage	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	tumour	tumour	NN	NN	_	6	compound	_	_
3	associated	associated	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	surface	surface	NN	NN	_	6	compound	_	_
6	antigen	antigen	NN	NN	_	9	nsubj	_	_
7	A6H	a6h	NN	NN	_	6	dep	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	costimulatory	costimulatory	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	CD4+	cd4+	JJ	JJ	_	9	nmod	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	12	cc	_	_
15	CD8+	cd8+	JJ	JJ	_	12	conj	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	dep	_	_
18	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	A6H	a6h	NN	NN	_	4	compound	_	_
3	monoclonal	monoclonal	JJ	JJ	_	4	amod	_	_
4	antibody	antibody	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	mAb	mab	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	recognizes	recognize	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	120,000-140,000	120,000-140,000	CD	CD	_	12	nummod	_	_
11	MW	mw	NN	NN	_	12	compound	_	_
12	antigen	antigen	NN	NN	_	8	dobj	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	expressed	express	VBN	VBN	_	12	acl:relcl	_	_
16	at	at	IN	IN	_	18	case	_	_
17	similar	similar	JJ	JJ	_	18	amod	_	_
18	densities	density	NNS	NNS	_	15	nmod	_	_
19	on	on	IN	IN	_	21	case	_	_
20	85-90	85-90	CD	CD	_	21	amod	_	_
21	%	%	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	CD4+	cd4+	JJ	JJ	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	CD8+	cd8+	JJ	JJ	_	24	conj	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	dep	_	_
29	and	and	CC	CC	_	21	cc	_	_
30	on	on	IN	IN	_	33	case	_	_
31	renal	renal	JJ	JJ	_	33	amod	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	carcinomas	carcinoma	NNS	NNS	_	21	conj	_	_
34	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	A6H	a6h	NN	NN	_	6	compound	_	_
6	mAb	mab	NN	NN	_	2	nmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	costimulatory	costimulatory	JJ	JJ	_	10	amod	_	_
10	signal	signal	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	anti-CD3	anti-cd3	JJ	JJ	_	15	amod	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	report	report	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	show	show	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	A6H	a6h	NN	NN	_	10	nsubj	_	_
10	costimulated	costimulate	VBD	VBD	_	7	ccomp	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	12	conj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	purified	purify	VBN	VBN	_	20	amod	_	_
18	CD4+	cd4+	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	10	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	CD8+	cd8+	JJ	JJ	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	subpopulation	subpopulation	NN	NN	_	7	nsubj	_	_
7	failed	fail	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	respond	respond	VB	VB	_	7	xcomp	_	_
10	.	.	.	.	_	7	punct	_	_

1	CD4+	cd4+	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	9	nsubj	_	_
4	costimulated	costimulate	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	A6H	a6h	NN	NN	_	8	compound	_	_
8	mAb	mab	NN	NN	_	4	nmod	_	_
9	upregulated	upregulate	VBD	VBD	_	0	root	_	_
10	CD80	cd80	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	CD86	cd86	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	CD71	cd71	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	interleukin-2	interleukin-2	NN	NN	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	21	punct	_	_
18	IL-2	il-2	NN	NN	_	21	compound	_	_
19	)	)	-RRB-	-RRB-	_	21	punct	_	_
20	R	r	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	10	conj	_	_
22	,	,	,	,	_	10	punct	_	_
23	IL-2R	il-2r	NN	NN	_	24	compound	_	_
24	beta	beta	NN	NN	_	10	conj	_	_
25	and	and	CC	CC	_	10	cc	_	_
26	IL-2R	il-2r	NN	NN	_	27	compound	_	_
27	gamma	gamma	NN	NN	_	10	conj	_	_
28	,	,	,	,	_	9	punct	_	_
29	while	while	IN	IN	_	39	mark	_	_
30	no	no	DT	DT	_	32	neg	_	_
31	corresponding	corresponding	JJ	JJ	_	32	amod	_	_
32	up-regulation	up-regulation	NN	NN	_	39	nsubjpass	_	_
33	of	of	IN	IN	_	37	case	_	_
34	these	these	DT	DT	_	37	det	_	_
35	cell	cell	NN	NN	_	37	compound	_	_
36	surface	surface	NN	NN	_	37	compound	_	_
37	molecules	molecule	NNS	NNS	_	32	nmod	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	seen	see	VBN	VBN	_	9	advcl	_	_
40	in	in	IN	IN	_	43	case	_	_
41	CD8+	cd8+	JJ	JJ	_	43	amod	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	39	nmod	_	_
44	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	18	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	nature	nature	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	A6H	a6h	NN	NN	_	10	compound	_	_
10	mAb	mab	NN	NN	_	11	compound	_	_
11	costimulus	costimulus	NN	NN	_	6	nmod	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	4	nmod	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	examined	examine	VBN	VBN	_	0	root	_	_
19	induction	induction	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	OCT-1	oct-1	NN	NN	_	23	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	AP-1	ap-1	NN	NN	_	24	conj	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	24	conj	_	_
30	which	which	WDT	WDT	_	32	nsubjpass	_	_
31	are	be	VBP	VBP	_	32	auxpass	_	_
32	known	know	VBN	VBN	_	23	acl:relcl	_	_
33	to	to	TO	TO	_	36	mark	_	_
34	be	be	VB	VB	_	36	cop	_	_
35	transcriptional	transcriptional	JJ	JJ	_	36	amod	_	_
36	regulators	regulator	NNS	NNS	_	32	xcomp	_	_
37	of	of	IN	IN	_	39	case	_	_
38	several	several	JJ	JJ	_	39	amod	_	_
39	cytokine	cytokine	NN	NN	_	36	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	cytokine	cytokine	NN	NN	_	42	compound	_	_
42	receptor	receptor	NN	NN	_	39	conj	_	_
43	genes	gene	NNS	NNS	_	39	dep	_	_
44	,	,	,	,	_	39	punct	_	_
45	including	include	VBG	VBG	_	47	case	_	_
46	the	the	DT	DT	_	47	dep	_	_
47	IL-2	il-2	NN	NN	_	39	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	IL-2R	il-2r	NN	NN	_	47	conj	_	_
50	genes	gene	NNS	NNS	_	47	dep	_	_
51	.	.	.	.	_	18	punct	_	_

1	Co-ligation	co-ligation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	A6H	a6h	NN	NN	_	5	compound	_	_
5	antigen	antigen	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CD3	cd3	NN	NN	_	9	compound	_	_
9	complex	complex	NN	NN	_	5	conj	_	_
10	induced	induce	VBD	VBD	_	0	root	_	_
11	expression	expression	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	11	nmod	_	_
16	AP-1	ap-1	NN	NN	_	15	dep	_	_
17	in	in	IN	IN	_	20	case	_	_
18	CD4+	cd4+	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	10	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	whereas	whereas	IN	IN	_	35	mark	_	_
23	no	no	DT	DT	_	24	neg	_	_
24	increase	increase	NN	NN	_	35	nsubjpass	_	_
25	in	in	IN	IN	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	octamer-binding	octamer-binding	JJ	JJ	_	33	amod	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	Oct	oct	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	proteins	protein	NNS	NNS	_	27	conj	_	_
34	was	be	VBD	VBD	_	35	auxpass	_	_
35	seen	see	VBN	VBN	_	10	advcl	_	_
36	compared	compare	VBN	VBN	_	39	case	_	_
37	to	to	TO	TO	_	39	case	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	advcl	_	_
40	stimulated	stimulate	VBN	VBN	_	39	acl	_	_
41	with	with	IN	IN	_	42	case	_	_
42	anti-CD3	anti-cd3	NN	NN	_	40	nmod	_	_
43	alone	alone	RB	RB	_	42	advmod	_	_
44	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	induction	induction	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	AP-1	ap-1	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	seen	see	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	14	case	_	_
10	A6H	a6h	NN	NN	_	11	nmod:npmod	_	_
11	costimulated	costimulated	JJ	JJ	_	14	amod	_	_
12	CD8+	cd8+	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	both	both	CC	CC	_	7	dep	_	_
6	proximal	proximal	JJ	JJ	_	7	amod	_	_
7	steps	step	NNS	NNS	_	19	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	CD8+	cd8+	JJ	JJ	_	11	amod	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	as	as	RB	RB	_	7	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	the	the	DT	DT	_	17	det	_	_
16	later	later	JJ	JJ	_	17	amod	_	_
17	phases	phase	NNS	NNS	_	7	conj	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	unresponsive	unresponsive	JJ	JJ	_	3	ccomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	A6H	a6h	NN	NN	_	22	compound	_	_
22	ligation	ligation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	differences	difference	NNS	NNS	_	18	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	A6H	a6h	NN	NN	_	6	compound	_	_
6	molecule	molecule	NN	NN	_	2	nmod	_	_
7	or	or	CC	CC	_	2	cc	_	_
8	distinct	distinct	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	A6H	a6h	NN	NN	_	13	nmod:npmod	_	_
13	transduced	transduced	JJ	JJ	_	16	amod	_	_
14	AP-1	ap-1	NN	NN	_	16	compound	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	pathway	pathway	NN	NN	_	9	nmod	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	exist	exist	VB	VB	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	CD4+	cd4+	JJ	JJ	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	CD8+	cd8+	JJ	JJ	_	20	conj	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	subpopulations	subpopulation	NNS	NNS	_	20	dep	_	_
26	.	.	.	.	_	18	punct	_	_

1	Inhibitor	inhibitor	NN	NN	_	14	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IK	ik	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	of	of	IN	IN	_	12	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	12	compound	_	_
7	induced	induced	JJ	JJ	_	12	amod	_	_
8	HLA	hla	NN	NN	_	11	compound	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	antigens	antigen	NNS	NNS	_	12	compound	_	_
12	expression	expression	NN	NN	_	1	nmod	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
15	HLA	hla	NN	NN	_	16	compound	_	_
16	class	class	NN	NN	_	19	compound	_	_
17	II	ii	CD	CD	_	16	nummod	_	_
18	constitutive	constitutive	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	14	dobj	_	_
20	in	in	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	human	human	JJ	JJ	_	26	amod	_	_
23	Raji	raji	NN	NN	_	26	compound	_	_
24	B	b	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	12	case	_	_
4	major	major	JJ	JJ	_	12	amod	_	_
5	histocompatibility	histocompatibility	NN	NN	_	12	compound	_	_
6	complex	complex	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	12	punct	_	_
8	MHC	mhc	NN	NN	_	12	compound	_	_
9	)	)	-RRB-	-RRB-	_	12	punct	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	antigens	antigen	NNS	NNS	_	2	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	constitutive	constitutive	JJ	JJ	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	professional	professional	JJ	JJ	_	19	amod	_	_
17	antigen	antigen	NN	NN	_	19	compound	_	_
18	presenting	presenting	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	APCs	apc	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	but	but	CC	CC	_	14	cc	_	_
24	can	can	MD	MD	_	27	aux	_	_
25	also	also	RB	RB	_	27	advmod	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	induced	induce	VBN	VBN	_	14	conj	_	_
28	by	by	IN	IN	_	29	case	_	_
29	interferon-gamma	interferon-gamma	NN	NN	_	27	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	IFN-gamma	ifn-gamma	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	on	on	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	majority	majority	NN	NN	_	27	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	non	non	JJ	JJ	_	40	amod	_	_
39	professional	professional	JJ	JJ	_	40	amod	_	_
40	APCs	apc	NNS	NNS	_	35	nmod	_	_
41	(	(	-LRB-	-LRB-	_	43	punct	_	_
42	e.g.	e.g.	FW	FW	_	43	dep	_	_
43	fibroblasts	fibroblast	NNS	NNS	_	40	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	characterised	characterise	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	4	dobj	_	_
8	called	call	VBN	VBN	_	7	acl	_	_
9	IK	ik	NN	NN	_	8	xcomp	_	_
10	which	which	WDT	WDT	_	14	nsubj	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	an	a	DT	DT	_	14	det	_	_
13	efficient	efficient	JJ	JJ	_	14	amod	_	_
14	inhibitor	inhibitor	NN	NN	_	9	acl:relcl	_	_
15	of	of	IN	IN	_	17	case	_	_
16	IFN-gamma	ifn-gamma	NN	NN	_	17	compound	_	_
17	induction	induction	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	MHC	mhc	NN	NN	_	22	compound	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	antigens	antigen	NNS	NNS	_	23	compound	_	_
23	expression	expression	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	IK	ik	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	MHC	mhc	NN	NN	_	12	compound	_	_
12	class	class	NN	NN	_	14	compound	_	_
13	II	ii	CD	CD	_	12	nummod	_	_
14	expression	expression	NN	NN	_	7	nmod	_	_
15	since	since	IN	IN	_	27	mark	_	_
16	over-expression	over-expression	NN	NN	_	27	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	protein	protein	NN	NN	_	16	nmod	_	_
20	by	by	IN	IN	_	22	case	_	_
21	stable	stable	JJ	JJ	_	22	amod	_	_
22	transfection	transfection	NN	NN	_	16	nmod	_	_
23	into	into	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	led	lead	VBD	VBD	_	4	advcl	_	_
28	to	to	TO	TO	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	total	total	JJ	JJ	_	31	amod	_	_
31	disappearance	disappearance	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	38	case	_	_
33	constitutive	constitutive	JJ	JJ	_	38	amod	_	_
34	MHC	mhc	NN	NN	_	37	compound	_	_
35	class	class	NN	NN	_	37	compound	_	_
36	II	ii	CD	CD	_	37	nummod	_	_
37	mRNA	mrna	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	transactivator	transactivator	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CIITA	ciita	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	necessary	necessary	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	constitutive	constitutive	JJ	JJ	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	12	conj	_	_
15	induced	induced	JJ	JJ	_	14	amod	_	_
16	MHC	mhc	NN	NN	_	17	compound	_	_
17	class	class	NN	NN	_	19	compound	_	_
18	II	ii	CD	CD	_	17	nummod	_	_
19	expressions	expression	NNS	NNS	_	12	dep	_	_
20	.	.	.	.	_	9	punct	_	_

1	Examination	examination	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CIITA	ciita	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	IK	ik	NN	NN	_	9	compound	_	_
7	stably	stably	RB	RB	_	9	advmod	_	_
8	transfected	transfect	VBN	VBN	_	9	amod	_	_
9	clones	clone	NNS	NNS	_	4	nmod	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	marked	marked	JJ	JJ	_	13	amod	_	_
13	reduction	reduction	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	CIITA	ciita	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IK	ik	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	5	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	key	key	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	MHC	mhc	NN	NN	_	22	compound	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	antigens	antigen	NNS	NNS	_	17	nmod	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	that	that	IN	IN	_	36	mark	_	_
25	inhibition	inhibition	NN	NN	_	36	nsubj	_	_
26	induced	induce	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	IK	ik	NN	NN	_	26	nmod	_	_
29	is	be	VBZ	VBZ	_	36	cop	_	_
30	upstream	upstream	JJ	JJ	_	36	advmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	CIITA	ciita	NN	NN	_	30	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	this	this	DT	DT	_	36	det	_	_
35	regulatory	regulatory	JJ	JJ	_	36	amod	_	_
36	pathway	pathway	NN	NN	_	10	conj	_	_
37	.	.	.	.	_	1	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	actions	action	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	prolactin	prolactin	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	immune	immune	JJ	JJ	_	8	amod	_	_
8	system	system	NN	NN	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunoregulatory	immunoregulatory	JJ	JJ	_	3	compound	_	_
3	properties	property	NNS	NNS	_	13	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	prolactin	prolactin	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	a	a	DT	DT	_	10	det	_	_
8	pituitary	pituitary	JJ	JJ	_	10	amod	_	_
9	peptide	peptide	NN	NN	_	10	compound	_	_
10	hormone	hormone	NN	NN	_	5	appos	_	_
11	,	,	,	,	_	3	punct	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	received	receive	VBN	VBN	_	0	root	_	_
14	renewed	renewed	JJ	JJ	_	15	amod	_	_
15	attention	attention	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	prolactin	prolactin	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	15	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	6	det	_	_
6	member	member	NN	NN	_	3	appos	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	hematopoietin/cytokine	hematopoietin/cytokine	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	superfamily	superfamily	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	ubiquitously	ubiquitously	RB	RB	_	15	advmod	_	_
15	expressed	express	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	cells	cell	NNS	NNS	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	immune	immune	JJ	JJ	_	21	amod	_	_
21	system	system	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Certain	certain	JJ	JJ	_	2	amod	_	_
2	subpopulations	subpopulation	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	synthesize	synthesize	VBP	VBP	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	secrete	secrete	VBP	VBP	_	5	conj	_	_
8	biologically	biologically	RB	RB	_	9	advmod	_	_
9	active	active	JJ	JJ	_	10	amod	_	_
10	prolactin	prolactin	NN	NN	_	5	dobj	_	_
11	,	,	,	,	_	5	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	suggests	suggest	VBZ	VBZ	_	5	dep	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	prolactin	prolactin	NN	NN	_	17	nsubj	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	act	act	VB	VB	_	13	ccomp	_	_
18	as	as	IN	IN	_	23	case	_	_
19	an	a	DT	DT	_	23	det	_	_
20	autocrine	autocrine	NN	NN	_	23	amod	_	_
21	and/or	and/or	CC	CC	_	20	cc	_	_
22	paracrine	paracrine	NN	NN	_	20	conj	_	_
23	factor	factor	NN	NN	_	17	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	modulate	modulate	VB	VB	_	17	xcomp	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activities	activity	NNS	NNS	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	cells	cell	NNS	NNS	_	27	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	immune	immune	JJ	JJ	_	33	amod	_	_
33	system	system	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	focuses	focus	VBZ	VBZ	_	0	root	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	actions	action	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	prolactin	prolactin	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	system	system	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Emphasis	emphasis	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	given	give	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	recent	recent	JJ	JJ	_	6	amod	_	_
6	information	information	NN	NN	_	3	nmod	_	_
7	about	about	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	prolactin	prolactin	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	signal	signal	NN	NN	_	15	compound	_	_
15	transduction	transduction	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	10	punct	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	signaling	signal	VBG	VBG	_	20	amod	_	_
20	molecules	molecule	NNS	NNS	_	10	conj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	prolactin-inducible	prolactin-inducible	JJ	JJ	_	24	amod	_	_
23	target	target	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	20	conj	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	participate	participate	VBP	VBP	_	20	acl:relcl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	these	these	DT	DT	_	29	det	_	_
29	responses	response	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	9	det	_	_
5	prolactin-inducible	prolactin-inducible	JJ	JJ	_	9	amod	_	_
6	interferon	interferon	NN	NN	_	9	compound	_	_
7	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
8	factor-1	factor-1	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	roles	role	NNS	NNS	_	9	conj	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	mediating	mediate	VBG	VBG	_	12	acl	_	_
15	diverse	diverse	JJ	JJ	_	17	amod	_	_
16	immune	immune	JJ	JJ	_	15	dep	_	_
17	responses	response	NNS	NNS	_	14	dobj	_	_
18	.	.	.	.	_	9	punct	_	_

1	Spontaneous	spontaneous	JJ	JJ	_	2	amod	_	_
2	occurrence	occurrence	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	early	early	JJ	JJ	_	8	amod	_	_
5	region	region	NN	NN	_	8	compound	_	_
6	1A	1a	NN	NN	_	8	compound	_	_
7	reiteration	reiteration	NN	NN	_	8	compound	_	_
8	mutants	mutant	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	type	type	NN	NN	_	12	compound	_	_
11	5	5	CD	CD	_	12	nummod	_	_
12	adenovirus	adenovirus	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	persistently	persistently	RB	RB	_	17	advmod	_	_
15	infected	infected	JJ	JJ	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	T-lymphocytes	t-lymphocyte	NNS	NNS	_	2	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Mutants	mutant	NNS	NNS	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	type	type	NN	NN	_	5	compound	_	_
4	5	5	CD	CD	_	5	nummod	_	_
5	adenovirus	adenovirus	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	Ad5	ad5	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	with	with	IN	IN	_	12	case	_	_
10	reiterated	reiterate	VBN	VBN	_	12	amod	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	sequences	sequence	NNS	NNS	_	1	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	E1a	e1a	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	12	nmod	_	_
17	appeared	appear	VBD	VBD	_	0	root	_	_
18	in	in	IN	IN	_	23	case	_	_
19	a	a	DT	DT	_	23	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	T-lymphocyte	t-lymphocyte	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	line	line	NN	NN	_	17	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	Molt-4	molt-4	NN	NN	_	23	appos	_	_
26	,	,	,	,	_	23	punct	_	_
27	persistently	persistently	RB	RB	_	28	advmod	_	_
28	infected	infect	VBN	VBN	_	23	acl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	H5sub304	h5sub304	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	a	a	DT	DT	_	34	det	_	_
33	deletion/substitution	deletion/substitution	NN	NN	_	34	compound	_	_
34	mutant	mutant	NN	NN	_	30	appos	_	_
35	that	that	WDT	WDT	_	36	nsubj	_	_
36	has	have	VBZ	VBZ	_	34	acl:relcl	_	_
37	a	a	DT	DT	_	39	det	_	_
38	wild-type	wild-type	JJ	JJ	_	39	amod	_	_
39	phenotype	phenotype	NN	NN	_	36	dobj	_	_
40	in	in	IN	IN	_	42	case	_	_
41	viral	viral	JJ	JJ	_	42	amod	_	_
42	replication	replication	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	17	punct	_	_

1	Endonuclease	endonuclease	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	sequencing	sequencing	NN	NN	_	2	conj	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	reiteration	reiteration	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	each	each	DT	DT	_	11	det	_	_
11	mutant	mutant	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	four	four	CD	CD	_	5	nummod	_	_
4	representative	representative	JJ	JJ	_	5	amod	_	_
5	mutants	mutant	NNS	NNS	_	12	nmod	_	_
6	investigated	investigate	VBN	VBN	_	5	acl	_	_
7	,	,	,	,	_	12	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	reiterations	reiteration	NNS	NNS	_	12	nsubj	_	_
11	all	all	DT	DT	_	12	advmod	_	_
12	started	start	VBD	VBD	_	0	root	_	_
13	within	within	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	six-base-pair	six-base-pair	JJ	JJ	_	17	amod	_	_
16	consensus	consensus	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	G	g	NN	NN	_	17	appos	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	or	or	CC	CC	_	22	cc	_	_
22	C	c	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	CTGTG	ctgtg	NN	NN	_	19	dep	_	_
25	,	,	,	,	_	17	punct	_	_
26	located	located	JJ	JJ	_	17	amod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	second	second	JJ	JJ	_	30	amod	_	_
30	exon	exon	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	E1a	e1a	NN	NN	_	34	compound	_	_
34	region	region	NN	NN	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	at	at	IN	IN	_	37	case	_	_
37	nt	nt	NN	NN	_	34	nmod	_	_
38	1333	1333	CD	CD	_	37	dep	_	_
39	,	,	,	,	_	37	punct	_	_
40	1367	1367	CD	CD	_	37	conj	_	_
41	,	,	,	,	_	37	punct	_	_
42	or	or	CC	CC	_	37	cc	_	_
43	1419	1419	CD	CD	_	37	conj	_	_
44	)	)	-RRB-	-RRB-	_	37	punct	_	_
45	.	.	.	.	_	12	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	not	not	RB	RB	_	2	neg	_	_
4	any	any	DT	DT	_	6	det	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	homology	homology	NN	NN	_	2	nsubj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	breakpoints	breakpoint	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	second	second	JJ	JJ	_	13	amod	_	_
13	exon	exon	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	inserting	inserting	JJ	JJ	_	17	amod	_	_
17	sequences	sequence	NNS	NNS	_	9	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	starting	start	VBG	VBG	_	17	dep	_	_
20	at	at	IN	IN	_	21	case	_	_
21	nt	nt	NN	NN	_	19	nmod	_	_
22	532	532	CD	CD	_	21	dep	_	_
23	,	,	,	,	_	21	punct	_	_
24	710	710	CD	CD	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	or	or	CC	CC	_	21	cc	_	_
27	792	792	CD	CD	_	21	conj	_	_
28	)	)	-RRB-	-RRB-	_	19	punct	_	_
29	.	.	.	.	_	2	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	reiterated	reiterate	VBN	VBN	_	8	amod	_	_
7	splicing	splicing	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	15	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	representative	representative	JJ	JJ	_	12	amod	_	_
12	mutants	mutant	NNS	NNS	_	8	nmod	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	all	all	DT	DT	_	15	advmod	_	_
15	used	use	VBN	VBN	_	3	dep	_	_
16	in	in	IN	IN	_	18	case	_	_
17	RNA	rna	NN	NN	_	18	compound	_	_
18	splicing	splicing	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	the	the	DT	DT	_	26	det	_	_
22	closest	closest	JJS	JJS	_	26	amod	_	_
23	donor	donor	NN	NN	_	26	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	recipient	recipient	NN	NN	_	23	conj	_	_
26	joints	joint	NNS	NNS	_	28	nsubjpass	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	used	use	VBN	VBN	_	15	conj	_	_
29	most	most	RBS	RBS	_	30	advmod	_	_
30	frequently	frequently	RB	RB	_	28	advmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	during	during	IN	IN	_	7	case	_	_
6	persistent	persistent	JJ	JJ	_	7	amod	_	_
7	infection	infection	NN	NN	_	9	nmod	_	_
8	Ad5	ad5	NN	NN	_	9	nsubj	_	_
9	underwent	undergo	VBD	VBD	_	3	ccomp	_	_
10	spontaneous	spontaneous	JJ	JJ	_	11	amod	_	_
11	mutations	mutation	NNS	NNS	_	9	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	sequence-specific	sequence-specific	JJ	JJ	_	14	amod	_	_
14	breakage	breakage	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	nonhomologous	nonhomologous	JJ	JJ	_	20	amod	_	_
17	end-end	end-end	JJ	JJ	_	20	amod	_	_
18	joining	joining	NN	NN	_	20	compound	_	_
19	recombination	recombination	NN	NN	_	20	compound	_	_
20	events	event	NNS	NNS	_	14	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	E1a	e1a	NN	NN	_	4	compound	_	_
3	reiteration	reiteration	NN	NN	_	4	compound	_	_
4	mutants	mutant	NNS	NNS	_	7	nsubjpass	_	_
5	could	could	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	propagated	propagate	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	HeLa	hela	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	A549	a549	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	KB	kb	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	conj	_	_
16	;	;	:	:	_	7	punct	_	_
17	they	they	PRP	PRP	_	20	nsubj	_	_
18	were	be	VBD	VBD	_	20	cop	_	_
19	genetically	genetically	RB	RB	_	20	advmod	_	_
20	stable	stable	JJ	JJ	_	7	parataxis	_	_
21	;	;	:	:	_	20	punct	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	they	they	PRP	PRP	_	24	nsubj	_	_
24	killed	kill	VBD	VBD	_	20	conj	_	_
25	CREF	cref	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	24	dobj	_	_
27	at	at	IN	IN	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	strikingly	strikingly	RB	RB	_	30	advmod	_	_
30	high	high	JJ	JJ	_	31	amod	_	_
31	frequency	frequency	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	Preliminary	preliminary	JJ	JJ	_	2	amod	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	tend	tend	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	correlate	correlate	VB	VB	_	3	xcomp	_	_
6	this	this	DT	DT	_	9	det	_	_
7	CREF	cref	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	killing	killing	NN	NN	_	5	dobj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	accumulation	accumulation	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	early	early	JJ	JJ	_	17	amod	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	proteins	protein	NNS	NNS	_	12	nmod	_	_
18	and/or	and/or	CC	CC	_	17	cc	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	DNA	dna	NN	NN	_	17	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	infected	infected	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	12	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	degree	degree	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	damage	damage	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	Ad5wt	ad5wt	NN	NN	_	8	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	H5sub304	h5sub304	NN	NN	_	10	conj	_	_
13	infection	infection	NN	NN	_	10	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	CREF	cref	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	observed	observe	VBN	VBN	_	4	amod	_	_
3	E1a	e1a	NN	NN	_	4	compound	_	_
4	reiterations	reiteration	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	model	model	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	gain	gain	VB	VB	_	7	acl	_	_
10	insight	insight	NN	NN	_	9	dobj	_	_
11	into	into	IN	IN	_	12	mark	_	_
12	understanding	understand	VBG	VBG	_	10	acl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	evolutionary	evolutionary	JJ	JJ	_	15	amod	_	_
15	events	event	NNS	NNS	_	12	dobj	_	_
16	of	of	IN	IN	_	24	case	_	_
17	some	some	DT	DT	_	24	det	_	_
18	,	,	,	,	_	24	punct	_	_
19	if	if	IN	IN	_	20	mark	_	_
20	not	not	RB	RB	_	24	ccomp	_	_
21	all	all	DT	DT	_	20	dep	_	_
22	,	,	,	,	_	24	punct	_	_
23	adenovirus	adenovirus	NN	NN	_	24	dep	_	_
24	types	type	NNS	NNS	_	15	nmod	_	_
25	during	during	IN	IN	_	27	case	_	_
26	many	many	JJ	JJ	_	27	amod	_	_
27	years	year	NNS	NNS	_	15	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	symbiotic	symbiotic	JJ	JJ	_	32	amod	_	_
30	,	,	,	,	_	29	punct	_	_
31	persistent	persistent	JJ	JJ	_	29	dep	_	_
32	relationship	relationship	NN	NN	_	27	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	tonsils	tonsil	NNS	NNS	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	adenoids	adenoids	NNS	NNS	_	35	conj	_	_
38	and	and	CC	CC	_	35	cc	_	_
39	possibly	possibly	RB	RB	_	41	advmod	_	_
40	other	other	JJ	JJ	_	41	amod	_	_
41	lymphoid	lymphoid	JJ	JJ	_	42	amod	_	_
42	organs	organ	NNS	NNS	_	35	conj	_	_
43	.	.	.	.	_	5	punct	_	_

1	Quantification	quantification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	vitamin	vitamin	NN	NN	_	6	compound	_	_
4	D	d	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	competitive	competitive	JJ	JJ	_	11	amod	_	_
9	polymerase	polymerase	NN	NN	_	11	compound	_	_
10	chain	chain	NN	NN	_	11	compound	_	_
11	reaction	reaction	NN	NN	_	1	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	PBMC	pbmc	NN	NN	_	11	nmod	_	_
14	:	:	:	:	_	1	punct	_	_
15	lack	lack	NN	NN	_	1	dep	_	_
16	of	of	IN	IN	_	17	case	_	_
17	correspondence	correspondence	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	common	common	JJ	JJ	_	21	amod	_	_
20	allelic	allelic	JJ	JJ	_	21	amod	_	_
21	variants	variant	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	been	be	VBN	VBN	_	5	auxpass	_	_
4	recently	recently	RB	RB	_	5	advmod	_	_
5	claimed	claim	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	polymorphism	polymorphism	NN	NN	_	16	nsubj	_	_
8	for	for	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	vitamin	vitamin	NN	NN	_	12	compound	_	_
11	D	d	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	VDR	vdr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	influences	influence	VBZ	VBZ	_	5	ccomp	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	aspects	aspect	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	calcium	calcium	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	bone	bone	NN	NN	_	20	conj	_	_
23	metabolism	metabolism	NN	NN	_	20	dep	_	_
24	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	evaluate	evaluate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	physiologic	physiologic	JJ	JJ	_	5	amod	_	_
5	plausibility	plausibility	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	claims	claim	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	compared	compare	VBD	VBD	_	2	parataxis	_	_
12	the	the	DT	DT	_	13	det	_	_
13	abundance	abundance	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	VDR	vdr	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
20	blood	blood	NN	NN	_	22	compound	_	_
21	mononuclear	mononuclear	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	PBMCs	pbmc	NNS	NNS	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	between	between	IN	IN	_	29	case	_	_
27	different	different	JJ	JJ	_	29	amod	_	_
28	VDR	vdr	NN	NN	_	29	compound	_	_
29	genotypes	genotype	NNS	NNS	_	11	nmod	_	_
30	using	use	VBG	VBG	_	11	xcomp	_	_
31	a	a	DT	DT	_	38	det	_	_
32	quantitative	quantitative	JJ	JJ	_	38	amod	_	_
33	reverse	reverse	JJ	JJ	_	38	amod	_	_
34	transcribed	transcribe	VBN	VBN	_	38	amod	_	_
35	polymerase	polymerase	NN	NN	_	38	compound	_	_
36	chain	chain	NN	NN	_	38	compound	_	_
37	reaction-based	reaction-based	JJ	JJ	_	38	amod	_	_
38	method	method	NN	NN	_	30	dobj	_	_
39	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	method	method	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	based	base	VBN	VBN	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	coamplification	coamplification	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	VDR	vdr	NN	NN	_	10	compound	_	_
10	cDNA	cdna	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	an	a	DT	DT	_	14	det	_	_
13	internal	internal	JJ	JJ	_	14	amod	_	_
14	standard	standard	NN	NN	_	10	conj	_	_
15	consisting	consist	VBG	VBG	_	14	acl	_	_
16	of	of	IN	IN	_	18	case	_	_
17	known	known	JJ	JJ	_	18	amod	_	_
18	concentrations	concentration	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	VDR	vdr	NN	NN	_	23	compound	_	_
23	CDNA	cdna	NN	NN	_	18	nmod	_	_
24	mutated	mutate	VBN	VBN	_	23	acl	_	_
25	at	at	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	BglII	bglii	NN	NN	_	29	compound	_	_
28	restriction	restriction	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	24	nmod	_	_
30	;	;	:	:	_	4	punct	_	_
31	the	the	DT	DT	_	33	det	_	_
32	interassay	interassay	JJ	JJ	_	33	amod	_	_
33	coefficient	coefficient	NN	NN	_	38	nsubj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	variation	variation	NN	NN	_	33	nmod	_	_
36	is	be	VBZ	VBZ	_	38	cop	_	_
37	11	11	CD	CD	_	38	nummod	_	_
38	%	%	NN	NN	_	4	parataxis	_	_
39	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	validate	validate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	method	method	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	made	make	VBD	VBD	_	2	parataxis	_	_
8	use	use	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	earlier	earlier	JJR	JJR	_	13	amod	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	studies	study	NNS	NNS	_	7	nmod	_	_
14	indicating	indicate	VBG	VBG	_	13	acl	_	_
15	that	that	IN	IN	_	27	mark	_	_
16	normal	normal	JJ	JJ	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	27	nsubj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	activated	activate	VBN	VBN	_	18	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	but	but	CC	CC	_	20	cc	_	_
23	not	not	RB	RB	_	20	conj	_	_
24	resting	rest	VBG	VBG	_	23	amod	_	_
25	,	,	,	,	_	20	punct	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	20	conj	_	_
27	expressed	express	VBD	VBD	_	14	ccomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	VDR	vdr	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	concentration	concentration	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	VDR	vdr	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	11	cop	_	_
8	10(-8)	10(-8)	CD	CD	_	10	compound	_	_
9	to	to	TO	TO	_	10	dep	_	_
10	10(-7)	10(-7)	CD	CD	_	11	nummod	_	_
11	g/g	g/g	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	total	total	JJ	JJ	_	14	amod	_	_
14	RNA	rna	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	cell-sorted	cell-sorted	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	in	in	IN	IN	_	23	case	_	_
20	in	in	FW	FW	_	23	compound	_	_
21	vitro	vitro	FW	FW	_	23	compound	_	_
22	activated	activate	VBN	VBN	_	23	amod	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	17	conj	_	_
24	,	,	,	,	_	11	punct	_	_
25	but	but	CC	CC	_	11	cc	_	_
26	only	only	RB	RB	_	27	advmod	_	_
27	10(-12)	10(-12)	CD	CD	_	28	nummod	_	_
28	g/g	g/g	NN	NN	_	11	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	total	total	JJ	JJ	_	31	amod	_	_
31	mRNA	mrna	NN	NN	_	28	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	resting	rest	VBG	VBG	_	34	amod	_	_
34	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
35	,	,	,	,	_	11	punct	_	_
36	establishing	establish	VBG	VBG	_	11	advcl	_	_
37	that	that	IN	IN	_	48	mark	_	_
38	the	the	DT	DT	_	40	det	_	_
39	VDR	vdr	NN	NN	_	40	compound	_	_
40	mRNA	mrna	NN	NN	_	48	nsubj	_	_
41	determined	determine	VBN	VBN	_	40	acl	_	_
42	by	by	IN	IN	_	44	case	_	_
43	our	we	PRP$	PRP$	_	44	nmod:poss	_	_
44	method	method	NN	NN	_	41	nmod	_	_
45	in	in	IN	IN	_	46	case	_	_
46	PBMCs	pbmc	NNS	NNS	_	44	nmod	_	_
47	is	be	VBZ	VBZ	_	48	cop	_	_
48	due	due	JJ	JJ	_	36	ccomp	_	_
49	to	to	TO	TO	_	51	case	_	_
50	constitutive	constitutive	JJ	JJ	_	51	amod	_	_
51	expression	expression	NN	NN	_	48	nmod	_	_
52	in	in	IN	IN	_	53	case	_	_
53	monocytes	monocyte	NNS	NNS	_	51	nmod	_	_
54	.	.	.	.	_	11	punct	_	_

1	Following	follow	VBG	VBG	_	5	case	_	_
2	an	a	DT	DT	_	5	det	_	_
3	initial	initial	JJ	JJ	_	5	amod	_	_
4	genotype	genotype	NN	NN	_	5	compound	_	_
5	screening	screening	NN	NN	_	41	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	85	85	CD	CD	_	9	nummod	_	_
8	normal	normal	JJ	JJ	_	9	amod	_	_
9	volunteers	volunteer	NNS	NNS	_	5	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	polymerase	polymerase	NN	NN	_	13	compound	_	_
12	chain	chain	NN	NN	_	13	compound	_	_
13	reaction	reaction	NN	NN	_	5	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	restriction	restriction	NN	NN	_	18	compound	_	_
16	fragment	fragment	NN	NN	_	18	compound	_	_
17	length	length	NN	NN	_	18	compound	_	_
18	polymorphism	polymorphism	NN	NN	_	19	compound	_	_
19	analysis	analysis	NN	NN	_	13	conj	_	_
20	,	,	,	,	_	41	punct	_	_
21	14	14	CD	CD	_	22	nummod	_	_
22	individuals	individual	NNS	NNS	_	41	nsubjpass	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	Bb	bb	NN	NN	_	26	compound	_	_
26	genotype	genotype	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	22	punct	_	_
28	12	12	CD	CD	_	22	conj	_	_
29	with	with	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	bb	bb	NN	NN	_	32	compound	_	_
32	genotype	genotype	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	22	punct	_	_
34	and	and	CC	CC	_	22	cc	_	_
35	12	12	CD	CD	_	22	conj	_	_
36	with	with	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	BB	bb	NN	NN	_	39	compound	_	_
39	genotype	genotype	NN	NN	_	35	nmod	_	_
40	were	be	VBD	VBD	_	41	auxpass	_	_
41	selected	select	VBN	VBN	_	0	root	_	_
42	.	.	.	.	_	41	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	concentration	concentration	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	VDR	vdr	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	corrected	correct	VBN	VBN	_	2	acl	_	_
9	for	for	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	similar	similar	JJ	JJ	_	0	root	_	_
17	among	among	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	three	three	CD	CD	_	21	nummod	_	_
20	genotype	genotype	NN	NN	_	21	compound	_	_
21	groups	group	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	as	as	IN	IN	_	27	dep	_	_
24	were	be	VBD	VBD	_	27	dep	_	_
25	the	the	DT	DT	_	27	det	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	variables	variable	NNS	NNS	_	16	advcl	_	_
28	examined	examine	VBN	VBN	_	27	acl	_	_
29	:	:	:	:	_	16	punct	_	_
30	serum	serum	NN	NN	_	31	compound	_	_
31	calcitriol	calcitriol	NN	NN	_	16	dep	_	_
32	,	,	,	,	_	31	punct	_	_
33	serum	serum	NN	NN	_	34	compound	_	_
34	osteocalcin	osteocalcin	NN	NN	_	31	conj	_	_
35	,	,	,	,	_	31	punct	_	_
36	and	and	CC	CC	_	31	cc	_	_
37	vertebral	vertebral	NN	NN	_	31	conj	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	hip	hip	NN	NN	_	40	compound	_	_
40	bone	bone	NN	NN	_	37	conj	_	_
41	density	density	NN	NN	_	37	dep	_	_
42	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	VDR	vdr	NN	NN	_	5	compound	_	_
5	polymorphism	polymorphism	NN	NN	_	8	nsubj	_	_
6	does	do	VBZ	VBZ	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	affect	affect	VB	VB	_	2	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	abundance	abundance	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	VDR	vdr	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	HLA-DMA	hla-dma	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	HLA-DMB	hla-dmb	NN	NN	_	1	conj	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	dep	_	_
6	functions	function	VBZ	VBZ	_	0	root	_	_
7	through	through	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	conserved	conserve	VBN	VBN	_	11	amod	_	_
10	S-X-Y	s-x-y	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	MHC	mhc	NN	NN	_	6	compound	_	_
3	class	class	NN	NN	_	6	compound	_	_
4	II	ii	CD	CD	_	6	nummod	_	_
5	homologous	homologous	JJ	JJ	_	6	amod	_	_
6	proteins	protein	NNS	NNS	_	10	nsubj	_	_
7	HLA-DMA	hla-dma	NN	NN	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	HLA-DMB	hla-dmb	NN	NN	_	7	conj	_	_
10	function	function	VBP	VBP	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	loading	loading	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	peptides	peptide	NNS	NNS	_	13	nmod	_	_
16	onto	onto	IN	IN	_	19	case	_	_
17	class	class	NN	NN	_	19	compound	_	_
18	II	ii	CD	CD	_	19	nummod	_	_
19	molecules	molecule	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Like	like	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	genes	gene	NNS	NNS	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HLA-DM	hla-dm	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	10	nsubj	_	_
10	contain	contain	VBP	VBP	_	0	root	_	_
11	upstream	upstream	JJ	JJ	_	13	amod	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	sequences	sequence	NNS	NNS	_	10	dobj	_	_
14	similar	similar	JJ	JJ	_	13	amod	_	_
15	to	to	TO	TO	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	S-X-Y	s-x-y	NN	NN	_	19	compound	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	region	region	NN	NN	_	14	nmod	_	_
20	as	as	RB	RB	_	13	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	additional	additional	JJ	JJ	_	25	amod	_	_
24	putative	putative	JJ	JJ	_	25	amod	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	sites	site	NNS	NNS	_	13	conj	_	_
27	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	8	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	DM	dm	NN	NN	_	6	compound	_	_
6	genes	gene	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	regulated	regulate	VBN	VBN	_	2	ccomp	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	similar	similar	JJ	JJ	_	12	amod	_	_
12	manner	manner	NN	NN	_	8	nmod	_	_
13	as	as	IN	IN	_	16	case	_	_
14	class	class	NN	NN	_	16	compound	_	_
15	II	ii	CD	CD	_	16	nummod	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	a	a	DT	DT	_	19	det	_	_
19	series	series	NN	NN	_	28	nsubjpass	_	_
20	of	of	IN	IN	_	21	case	_	_
21	in	in	FW	FW	_	19	nmod	_	_
22	vivo	vivo	FW	FW	_	21	dep	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	in	in	FW	FW	_	21	conj	_	_
25	vitro	vitro	FW	FW	_	24	dep	_	_
26	analyses	analysis	NNS	NNS	_	21	dep	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	performed	perform	VBN	VBN	_	2	parataxis	_	_
29	.	.	.	.	_	2	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	expression	expression	NN	NN	_	11	nsubj	_	_
6	from	from	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	DM	dm	NN	NN	_	9	compound	_	_
9	promoters	promoter	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	dependent	dependent	JJ	JJ	_	3	ccomp	_	_
12	on	on	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	conserved	conserve	VBN	VBN	_	16	amod	_	_
15	S-X-Y	s-x-y	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	class	class	NN	NN	_	5	compound	_	_
3	II-specific	ii-specific	JJ	JJ	_	5	amod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	11	nsubjpass	_	_
6	RFX	rfx	NN	NN	_	5	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CIITA	ciita	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	13	case	_	_
13	expression	expression	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	as	as	IN	IN	_	22	mark	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	22	nsubj	_	_
18	deficient	deficient	JJ	JJ	_	17	amod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	factors	factor	NNS	NNS	_	18	nmod	_	_
22	failed	fail	VBD	VBD	_	11	advcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	allow	allow	VB	VB	_	22	xcomp	_	_
25	transcription	transcription	NN	NN	_	24	dobj	_	_
26	from	from	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	DM	dm	NN	NN	_	29	compound	_	_
29	promoters	promoter	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	in	in	FW	FW	_	7	amod	_	_
5	vivo	vivo	FW	FW	_	4	dep	_	_
6	footprint	footprint	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	dep	_	_
10	putative	putative	JJ	JJ	_	11	amod	_	_
11	X	x	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Y	y	NN	NN	_	11	conj	_	_
14	boxes	box	NNS	NNS	_	11	dep	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	occupied	occupy	VBN	VBN	_	8	xcomp	_	_
18	by	by	IN	IN	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	wild-type	wild-type	JJ	JJ	_	24	amod	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	but	but	CC	CC	_	24	cc	_	_
27	not	not	RB	RB	_	31	neg	_	_
28	in	in	IN	IN	_	31	case	_	_
29	RFX-deficient	rfx-deficient	JJ	JJ	_	31	amod	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	24	conj	_	_
32	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	astrocytes	astrocyte	NNS	NNS	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	IFN-gamma	ifn-gamma	NN	NN	_	5	compound	_	_
5	treatment	treatment	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	increased	increase	VBN	VBN	_	8	amod	_	_
8	occupancy	occupancy	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	sites	site	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	None	none	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	other	other	JJ	JJ	_	6	amod	_	_
5	putative	putative	JJ	JJ	_	6	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	sites	site	NNS	NNS	_	1	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	occupied	occupy	VBN	VBN	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	indicating	indicate	VBG	VBG	_	9	advcl	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	they	they	PRP	PRP	_	19	nsubj	_	_
16	may	may	MD	MD	_	19	aux	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	be	be	VB	VB	_	19	cop	_	_
19	functional	functional	JJ	JJ	_	13	ccomp	_	_
20	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	gel	gel	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	6	nsubj	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	synergistic	synergistic	JJ	JJ	_	9	amod	_	_
8	complex	complex	JJ	JJ	_	9	amod	_	_
9	formation	formation	NN	NN	_	6	dobj	_	_
10	between	between	IN	IN	_	11	case	_	_
11	proteins	protein	NNS	NNS	_	9	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	bind	bind	VBP	VBP	_	11	acl:relcl	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	putative	putative	JJ	JJ	_	18	amod	_	_
17	X	x	NN	NN	_	18	compound	_	_
18	boxes	box	NNS	NNS	_	13	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	DM	dm	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	as	as	IN	IN	_	26	dep	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	found	find	VBN	VBN	_	6	advcl	_	_
27	for	for	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	DRA	dra	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Therefore	therefore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	DM	dm	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	6	nsubj	_	_
6	share	share	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	common	common	JJ	JJ	_	9	amod	_	_
9	mechanism	mechanism	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	regulation	regulation	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	class	class	NN	NN	_	16	compound	_	_
15	II	ii	CD	CD	_	16	nummod	_	_
16	genes	gene	NNS	NNS	_	6	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	enhancer-blocking	enhancer-blocking	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	0	root	_	_
4	between	between	IN	IN	_	5	case	_	_
5	alpha	alpha	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	delta	delta	NN	NN	_	5	conj	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	segments	segment	NNS	NNS	_	5	dep	_	_
10	within	within	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	human	human	JJ	JJ	_	17	amod	_	_
13	T	t	NN	NN	_	17	compound	_	_
14	cell	cell	NN	NN	_	17	compound	_	_
15	receptor	receptor	NN	NN	_	17	compound	_	_
16	alpha/delta	alpha/delta	NN	NN	_	17	compound	_	_
17	locus	locus	NN	NN	_	3	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	T	t	NN	NN	_	7	compound	_	_
2	cell	cell	NN	NN	_	7	compound	_	_
3	receptor	receptor	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	TCR	tcr	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	alpha	alpha	NN	NN	_	13	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	delta	delta	NN	NN	_	7	conj	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	segments	segment	NNS	NNS	_	7	dep	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	organized	organize	VBN	VBN	_	0	root	_	_
14	within	within	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	single	single	JJ	JJ	_	18	amod	_	_
17	genetic	genetic	JJ	JJ	_	18	amod	_	_
18	locus	locus	NN	NN	_	13	nmod	_	_
19	but	but	CC	CC	_	13	cc	_	_
20	are	be	VBP	VBP	_	22	auxpass	_	_
21	differentially	differentially	RB	RB	_	22	advmod	_	_
22	regulated	regulate	VBN	VBN	_	13	conj	_	_
23	during	during	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	development	development	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	enhancer-blocking	enhancer-blocking	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	14	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	BEAD-1	bead-1	NN	NN	_	3	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	for	for	IN	IN	_	8	mark	_	_
8	blocking	block	VBG	VBG	_	5	acl	_	_
9	element	element	NN	NN	_	10	compound	_	_
10	alpha/delta	alpha/delta	NN	NN	_	8	dobj	_	_
11	1	1	CD	CD	_	10	nummod	_	_
12	)	)	-RRB-	-RRB-	_	5	punct	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	localized	localized	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	2.0-kb	2.0-kb	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	3'	3'	RB	RB	_	25	advmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	TCR	tcr	NN	NN	_	24	compound	_	_
22	delta	delta	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	segments	segment	NNS	NNS	_	19	nmod	_	_
25	and	and	CC	CC	_	18	advmod	_	_
26	5'	5'	RB	RB	_	25	advmod	_	_
27	of	of	IN	IN	_	32	case	_	_
28	TCR	tcr	NN	NN	_	32	compound	_	_
29	alpha	alpha	NN	NN	_	32	compound	_	_
30	joining	joining	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	segments	segment	NNS	NNS	_	26	nmod	_	_
33	within	within	IN	IN	_	35	case	_	_
34	this	this	DT	DT	_	35	det	_	_
35	locus	locus	NN	NN	_	18	nmod	_	_
36	.	.	.	.	_	14	punct	_	_

1	BEAD-1	bead-1	NN	NN	_	2	nsubj	_	_
2	blocked	block	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	TCR	tcr	NN	NN	_	9	compound	_	_
8	delta	delta	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Edelta	edelta	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	activate	activate	VB	VB	_	4	acl	_	_
15	a	a	DT	DT	_	16	det	_	_
16	promoter	promoter	NN	NN	_	14	dobj	_	_
17	when	when	WRB	WRB	_	18	advmod	_	_
18	located	located	JJ	JJ	_	2	advcl	_	_
19	between	between	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	two	two	CD	CD	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	chromatin-integrated	chromatin-integrated	JJ	JJ	_	25	amod	_	_
25	construct	construct	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	BEAD-1	bead-1	NN	NN	_	5	nsubj	_	_
5	functions	function	VBZ	VBZ	_	2	ccomp	_	_
6	as	as	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	boundary	boundary	NN	NN	_	5	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	separates	separate	VBZ	VBZ	_	8	acl:relcl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	TCR	tcr	NN	NN	_	14	compound	_	_
13	alpha/delta	alpha/delta	NN	NN	_	14	compound	_	_
14	locus	locus	NN	NN	_	10	dobj	_	_
15	into	into	IN	IN	_	18	case	_	_
16	distinct	distinct	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	domains	domain	NNS	NNS	_	10	nmod	_	_
19	controlled	control	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	Edelta	edelta	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	TCR	tcr	NN	NN	_	26	compound	_	_
25	alpha	alpha	NN	NN	_	26	compound	_	_
26	enhancer	enhancer	NN	NN	_	21	conj	_	_
27	,	,	,	,	_	5	punct	_	_
28	and	and	CC	CC	_	5	cc	_	_
29	that	that	IN	IN	_	31	mark	_	_
30	it	it	PRP	PRP	_	31	nsubj	_	_
31	prevents	prevent	VBZ	VBZ	_	5	conj	_	_
32	Edelta	edelta	NN	NN	_	31	dobj	_	_
33	from	from	IN	IN	_	34	mark	_	_
34	opening	open	VBG	VBG	_	31	advcl	_	_
35	the	the	DT	DT	_	36	det	_	_
36	chromatin	chromatin	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	43	case	_	_
38	the	the	DT	DT	_	43	det	_	_
39	TCR	tcr	NN	NN	_	40	compound	_	_
40	alpha	alpha	NN	NN	_	43	compound	_	_
41	joining	joining	NN	NN	_	43	compound	_	_
42	gene	gene	NN	NN	_	43	compound	_	_
43	segments	segment	NNS	NNS	_	36	nmod	_	_
44	for	for	IN	IN	_	46	case	_	_
45	VDJ	vdj	NN	NN	_	46	compound	_	_
46	recombination	recombination	NN	NN	_	34	nmod	_	_
47	at	at	IN	IN	_	50	case	_	_
48	an	a	DT	DT	_	50	det	_	_
49	early	early	JJ	JJ	_	50	amod	_	_
50	stage	stage	NN	NN	_	31	nmod	_	_
51	of	of	IN	IN	_	54	case	_	_
52	T	t	NN	NN	_	54	compound	_	_
53	cell	cell	NN	NN	_	54	compound	_	_
54	development	development	NN	NN	_	50	nmod	_	_
55	.	.	.	.	_	2	punct	_	_

1	Plasma	plasma	NN	NN	_	3	compound	_	_
2	sialyltransferase	sialyltransferase	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	psychiatric	psychiatric	JJ	JJ	_	6	amod	_	_
6	disorders	disorder	NNS	NNS	_	3	nmod	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	possible	possible	JJ	JJ	_	10	amod	_	_
10	indicator	indicator	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	HPA	hpa	JJ	JJ	_	14	amod	_	_
13	axis	axis	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	dysfunction	dysfunction	NN	NN	_	29	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	12	amod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HPA	hpa	JJ	JJ	_	8	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	axis	axis	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	possibly	possibly	RB	RB	_	15	advmod	_	_
15	attributed	attribute	VBN	VBN	_	2	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	change	change	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	25	case	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	GR	gr	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	functionality	functionality	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	2	punct	_	_
27	has	have	VBZ	VBZ	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	implicated	implicate	VBN	VBN	_	0	root	_	_
30	in	in	IN	IN	_	31	case	_	_
31	depression	depression	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	29	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	measured	measure	VBN	VBN	_	0	root	_	_
4	both	both	CC	CC	_	9	cc:preconj	_	_
5	lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	GR	gr	NN	NN	_	9	compound	_	_
7	receptor	receptor	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	parameters	parameter	NNS	NNS	_	3	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	plasma	plasma	NN	NN	_	13	compound	_	_
12	sialyltransferase	sialyltransferase	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	3	punct	_	_
15	as	as	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	biochemical	biochemical	JJ	JJ	_	18	amod	_	_
18	marker	marker	NN	NN	_	3	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	GR	gr	NN	NN	_	21	compound	_	_
21	function	function	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	3	punct	_	_
23	in	in	IN	IN	_	25	case	_	_
24	two	two	CD	CD	_	25	nummod	_	_
25	groups	group	NNS	NNS	_	3	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	patients	patient	NNS	NNS	_	25	nmod	_	_
28	suffering	suffer	VBG	VBG	_	27	acl	_	_
29	from	from	IN	IN	_	30	case	_	_
30	depression	depression	NN	NN	_	28	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	schizophrenia	schizophrenia	NN	NN	_	30	conj	_	_
33	and	and	CC	CC	_	25	cc	_	_
34	in	in	IN	IN	_	36	case	_	_
35	a	a	DT	DT	_	36	det	_	_
36	group	group	NN	NN	_	25	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	age-	age-	NN	NN	_	36	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	sex-matched	sex-matched	JJ	JJ	_	38	conj	_	_
41	controls	control	NNS	NNS	_	38	dep	_	_
42	.	.	.	.	_	3	punct	_	_

1	While	while	IN	IN	_	3	mark	_	_
2	there	there	EX	EX	_	3	expl	_	_
3	was	be	VBD	VBD	_	17	advcl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	increase	increase	NN	NN	_	3	nsubj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	plasma	plasma	NN	NN	_	10	compound	_	_
9	cortisol	cortisol	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	depressed	depressed	JJ	JJ	_	14	amod	_	_
14	group	group	NN	NN	_	3	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	there	there	EX	EX	_	17	expl	_	_
17	were	be	VBD	VBD	_	0	root	_	_
18	no	no	DT	DT	_	19	neg	_	_
19	changes	change	NNS	NNS	_	17	nsubj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	lymphocyte	lymphocyte	NN	NN	_	25	compound	_	_
23	GR	gr	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	parameters	parameter	NNS	NNS	_	19	nmod	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	K	k	NN	NN	_	29	compound	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	m	m	NN	NN	_	25	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	29	cc	_	_
32	Bmax	bmax	NN	NN	_	29	conj	_	_
33	)	)	-RRB-	-RRB-	_	29	punct	_	_
34	.	.	.	.	_	17	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	however	however	RB	RB	_	2	advmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	significant	significant	JJ	JJ	_	8	amod	_	_
8	decrease	decrease	NN	NN	_	2	nsubj	_	_
9	in	in	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	plasma	plasma	NN	NN	_	12	compound	_	_
12	sialyltransferase	sialyltransferase	NN	NN	_	15	compound	_	_
13	:	:	:	:	_	12	punct	_	_
14	cortisol	cortisol	NN	NN	_	15	compound	_	_
15	ratio	ratio	NN	NN	_	8	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	depressed	depressed	JJ	JJ	_	19	amod	_	_
19	group	group	NN	NN	_	2	nmod	_	_
20	suggesting	suggest	VBG	VBG	_	2	xcomp	_	_
21	an	a	DT	DT	_	22	det	_	_
22	inability	inability	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	raised	raise	VBN	VBN	_	27	amod	_	_
26	cortisol	cortisol	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	22	nmod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	induce	induce	VB	VB	_	22	acl	_	_
30	enzyme	enzyme	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	29	dobj	_	_
32	and	and	CC	CC	_	2	cc	_	_
33	this	this	DT	DT	_	34	det	_	_
34	ratio	ratio	NN	NN	_	36	nsubj	_	_
35	may	may	MD	MD	_	36	aux	_	_
36	provide	provide	VB	VB	_	2	conj	_	_
37	a	a	DT	DT	_	40	det	_	_
38	useful	useful	JJ	JJ	_	40	amod	_	_
39	biochemical	biochemical	JJ	JJ	_	38	dep	_	_
40	marker	marker	NN	NN	_	36	dobj	_	_
41	of	of	IN	IN	_	44	case	_	_
42	cortisol	cortisol	NN	NN	_	44	compound	_	_
43	receptor	receptor	NN	NN	_	44	compound	_	_
44	function	function	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	there	there	EX	EX	_	3	expl	_	_
3	was	be	VBD	VBD	_	25	advcl	_	_
4	an	a	DT	DT	_	5	det	_	_
5	increase	increase	NN	NN	_	3	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	plasma	plasma	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	alpha	alpha	NN	NN	_	15	compound	_	_
13	2,6	2,6	CD	CD	_	15	nummod	_	_
14	sialyltransferase	sialyltransferase	NN	NN	_	15	compound	_	_
15	isozyme	isozyme	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	schizophrenic	schizophrenic	JJ	JJ	_	19	amod	_	_
19	group	group	NN	NN	_	3	nmod	_	_
20	,	,	,	,	_	25	punct	_	_
21	no	no	DT	DT	_	23	neg	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	changes	change	NNS	NNS	_	25	nsubjpass	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	determined	determine	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	Therefore	therefore	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	while	while	IN	IN	_	11	mark	_	_
4	the	the	DT	DT	_	10	det	_	_
5	total	total	JJ	JJ	_	10	amod	_	_
6	plasma	plasma	NN	NN	_	7	compound	_	_
7	sialyltransferase	sialyltransferase	NN	NN	_	10	compound	_	_
8	:	:	:	:	_	10	punct	_	_
9	cortisol	cortisol	NN	NN	_	10	compound	_	_
10	ratio	ratio	NN	NN	_	11	nsubj	_	_
11	reflects	reflect	VBZ	VBZ	_	24	dep	_	_
12	HPA	hpa	JJ	JJ	_	14	amod	_	_
13	axis	axis	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	24	punct	_	_
16	alterations	alteration	NNS	NNS	_	24	nsubjpass	_	_
17	in	in	IN	IN	_	20	case	_	_
18	specific	specific	JJ	JJ	_	20	amod	_	_
19	isozyme	isozyme	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	may	may	MD	MD	_	24	aux	_	_
22	also	also	RB	RB	_	24	advmod	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	associated	associate	VBN	VBN	_	0	root	_	_
25	with	with	IN	IN	_	29	case	_	_
26	other	other	JJ	JJ	_	29	amod	_	_
27	CNS	cns	NN	NN	_	29	compound	_	_
28	disease	disease	NN	NN	_	29	compound	_	_
29	states	state	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	24	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	N-terminal	n-terminal	JJ	JJ	_	5	amod	_	_
5	region	region	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	mineralocorticoid	mineralocorticoid	NN	NN	_	12	compound	_	_
10	receptor	receptor	NN	NN	_	12	compound	_	_
11	hormone-binding	hormone-binding	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	5	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	agonist	agonist	NN	NN	_	1	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	antagonist	antagonist	NN	NN	_	14	conj	_	_
17	binding	binding	NN	NN	_	14	dep	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	revealed	reveal	VBN	VBN	_	1	dep	_	_
20	by	by	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	new	new	JJ	JJ	_	24	amod	_	_
23	monoclonal	monoclonal	JJ	JJ	_	24	amod	_	_
24	antibody	antibody	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	better	better	JJR	JJR	_	5	amod	_	_
5	understanding	understanding	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	mark	_	_
10	binding	bind	VBG	VBG	_	8	acl	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	mineralocorticoid	mineralocorticoid	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	hMR	hmr	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	2	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	developed	develop	VBD	VBD	_	2	parataxis	_	_
22	a	a	DT	DT	_	25	det	_	_
23	new	new	JJ	JJ	_	25	amod	_	_
24	monoclonal	monoclonal	JJ	JJ	_	25	amod	_	_
25	antibody	antibody	NN	NN	_	21	dobj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	mAb	mab	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	raised	raise	VBN	VBN	_	25	acl	_	_
30	against	against	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	hormone-binding	hormone-binding	JJ	JJ	_	33	amod	_	_
33	domain	domain	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	HBD	hbd	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	2	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	purpose	purpose	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	mice	mouse	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	immunized	immunize	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	fusion	fusion	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	7	nmod	_	_
12	including	include	VBG	VBG	_	11	acl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	sequence	sequence	NN	NN	_	12	dobj	_	_
15	Thr729-Lys984	thr729-lys984	NN	NN	_	14	dep	_	_
16	of	of	IN	IN	_	17	case	_	_
17	hMR	hmr	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	ELISA	elisa	NN	NN	_	3	compound	_	_
3	screening	screening	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	mAb	mab	NN	NN	_	6	compound	_	_
6	18C7	18c7	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	selected	select	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	specificity	specificity	NN	NN	_	8	nmod	_	_
12	towards	towards	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	HBD	hbd	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	antibody	antibody	NN	NN	_	3	nsubj	_	_
3	recognized	recognize	VBD	VBD	_	0	root	_	_
4	both	both	CC	CC	_	6	cc:preconj	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	denatured	denature	VBN	VBN	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	native	native	JJ	JJ	_	10	amod	_	_
9	MR	mr	NN	NN	_	10	compound	_	_
10	forms	form	NNS	NNS	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	as	as	RB	RB	_	6	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	the	the	DT	DT	_	18	det	_	_
16	hetero-oligomeric	hetero-oligomeric	JJ	JJ	_	18	amod	_	_
17	MR	mr	NN	NN	_	18	compound	_	_
18	form	form	NN	NN	_	6	conj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	transformed	transformed	JJ	JJ	_	23	amod	_	_
22	MR	mr	NN	NN	_	23	compound	_	_
23	state	state	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	12	advcl	_	_
3	several	several	JJ	JJ	_	5	amod	_	_
4	HBD	hbd	NN	NN	_	5	compound	_	_
5	subfragments	subfragment	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	12	punct	_	_
7	the	the	DT	DT	_	10	det	_	_
8	mAb	mab	NN	NN	_	10	compound	_	_
9	18C7	18c7	NN	NN	_	10	compound	_	_
10	epitope	epitope	NN	NN	_	12	nsubj	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	located	located	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	N-terminal	n-terminal	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	HBD	hbd	NN	NN	_	16	nmod	_	_
20	from	from	IN	IN	_	23	case	_	_
21	Thr729	thr729	NN	NN	_	23	compound	_	_
22	to	to	TO	TO	_	23	dep	_	_
23	Leu765	leu765	NN	NN	_	12	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	then	then	RB	RB	_	3	advmod	_	_
3	studied	study	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	antibody	antibody	NN	NN	_	5	nmod	_	_
9	on	on	IN	IN	_	10	case	_	_
10	aldosterone	aldosterone	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	progesterone	progesterone	NN	NN	_	10	conj	_	_
13	binding	binding	NN	NN	_	10	dep	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	hMR	hmr	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	18C7	18c7	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	incubated	incubate	VBN	VBN	_	11	advcl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	liganded	liganded	JJ	JJ	_	7	amod	_	_
7	MR	mr	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	it	it	PRP	PRP	_	11	nsubj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	able	able	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	partly	partly	RB	RB	_	14	advmod	_	_
14	displace	displace	VB	VB	_	11	xcomp	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	20	20	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	14	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	the	the	DT	DT	_	20	det	_	_
20	hormone	hormone	NN	NN	_	14	dobj	_	_
21	from	from	IN	IN	_	24	case	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	binding	bind	VBG	VBG	_	24	amod	_	_
24	site	site	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	18C7	18c7	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	incubated	incubate	VBN	VBN	_	14	advcl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	MR	mr	NN	NN	_	4	nmod	_	_
7	before	before	IN	IN	_	8	case	_	_
8	aldosterone	aldosterone	NN	NN	_	4	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	progesterone	progesterone	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	14	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	antibody	antibody	NN	NN	_	14	nsubj	_	_
14	inhibited	inhibit	VBD	VBD	_	0	root	_	_
15	75-80	75-80	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	binding	binding	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	18C7	18c7	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	binding	binding	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	hormones	hormone	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	sucrose	sucrose	NN	NN	_	4	compound	_	_
3	gradient	gradient	JJ	JJ	_	4	amod	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	simultaneous	simultaneous	JJ	JJ	_	8	amod	_	_
8	presence	presence	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	kinds	kind	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	complexes	complex	NNS	NNS	_	11	nmod	_	_
15	:	:	:	:	_	5	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	steroid-MR	steroid-mr	JJ	JJ	_	18	amod	_	_
18	complex	complex	NN	NN	_	5	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	antibody-MR	antibody-mr	JJ	JJ	_	22	amod	_	_
22	complex	complex	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	After	after	IN	IN	_	14	mark	_	_
2	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
3	associated	associate	VBN	VBN	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	14	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	especially	especially	RB	RB	_	10	advmod	_	_
7	the	the	DT	DT	_	10	det	_	_
8	heat-shock	heat-shock	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	hsp90	hsp90	NN	NN	_	4	appos	_	_
11	,	,	,	,	_	4	punct	_	_
12	had	have	VBD	VBD	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	cop	_	_
14	cross-linked	cross-linked	JJ	JJ	_	24	advcl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	hMR	hmr	NN	NN	_	14	nmod	_	_
18	by	by	IN	IN	_	19	case	_	_
19	dimethylpimelimidate	dimethylpimelimidate	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	24	punct	_	_
21	18C7	18c7	NN	NN	_	24	nsubj	_	_
22	was	be	VBD	VBD	_	24	cop	_	_
23	still	still	RB	RB	_	24	advmod	_	_
24	able	able	JJ	JJ	_	0	root	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	react	react	VB	VB	_	24	xcomp	_	_
27	with	with	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	receptor	receptor	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	24	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	epitope	epitope	NN	NN	_	12	nsubjpass	_	_
7	recognized	recognize	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	18C7	18c7	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	directly	directly	RB	RB	_	12	advmod	_	_
12	implicated	implicate	VBN	VBN	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	hormone	hormone	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	lack	lack	NN	NN	_	30	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	steroid	steroid	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	HBD	hbd	NN	NN	_	8	compound	_	_
8	mutants	mutant	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	Thr729-Leu765	thr729-leu765	JJ	JJ	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	8	nmod	_	_
13	deleted	delete	VBN	VBN	_	12	acl	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	Jalaguier	Jalaguier	NNP	NNP	_	2	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	Mesnier	Mesnier	NNP	NNP	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	Leger	Leger	NNP	NNP	_	15	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	Auzou	Auzou	NNP	NNP	_	15	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	1996	1996	CD	CD	_	15	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	J.Steroid	J.Steroid	NNP	NNP	_	26	compound	_	_
26	Biochem.Mol.Biol.57	Biochem.Mol.Biol.57	NNP	NNP	_	15	dep	_	_
27	,	,	,	,	_	15	punct	_	_
28	43-50	43-50	CD	CD	_	15	amod	_	_
29	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_
30	supports	support	VBZ	VBZ	_	0	root	_	_
31	this	this	DT	DT	_	32	det	_	_
32	hypothesis	hypothesis	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	30	punct	_	_

1	Because	because	IN	IN	_	5	case	_	_
2	of	of	IN	IN	_	1	mwe	_	_
3	the	the	DT	DT	_	5	det	_	_
4	similar	similar	JJ	JJ	_	5	amod	_	_
5	behaviours	behaviour	NNS	NNS	_	12	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	aldosterone	aldosterone	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	progesterone	progesterone	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	conclude	conclude	VBP	VBP	_	0	root	_	_
13	that	that	IN	IN	_	23	mark	_	_
14	the	the	DT	DT	_	17	det	_	_
15	N-terminal	n-terminal	JJ	JJ	_	17	amod	_	_
16	Thr729-Leu765	thr729-leu765	JJ	JJ	_	17	amod	_	_
17	region	region	NN	NN	_	23	nsubjpass	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	HBD	hbd	NN	NN	_	17	nmod	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	similarly	similarly	RB	RB	_	23	advmod	_	_
23	involved	involve	VBN	VBN	_	12	ccomp	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	binding	binding	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	both	both	DT	DT	_	29	det	_	_
29	hormones	hormone	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Triggering	triggering	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HLA-DR	hla-dr	NN	NN	_	4	compound	_	_
4	antigens	antigen	NNS	NNS	_	1	nmod	_	_
5	differentially	differentially	RB	RB	_	6	advmod	_	_
6	modulates	modulate	VBZ	VBZ	_	0	root	_	_
7	tumor	tumor	NN	NN	_	10	compound	_	_
8	necrosis	necrosis	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	release	release	NN	NN	_	6	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	at	at	IN	IN	_	17	case	_	_
16	distinct	distinct	JJ	JJ	_	17	amod	_	_
17	stage	stage	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	maturation	maturation	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Triggering	triggering	NN	NN	_	24	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	HLA	hla	NN	NN	_	6	compound	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	antigens	antigen	NNS	NNS	_	1	nmod	_	_
7	by	by	IN	IN	_	15	case	_	_
8	the	the	DT	DT	_	15	det	_	_
9	anti-HLA-DR	anti-hla-dr	JJ	JJ	_	15	amod	_	_
10	monoclonal	monoclonal	JJ	JJ	_	15	amod	_	_
11	antibody	antibody	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	mAb	mab	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	L243	l243	NN	NN	_	1	nmod	_	_
16	significantly	significantly	RB	RB	_	22	advmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	P	p	NN	NN	_	16	dep	_	_
19	&lt;	&lt;	JJR	JJR	_	18	amod	_	_
20	0.05	0.05	CD	CD	_	19	dep	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	and	and	CC	CC	_	24	advmod	_	_
23	differentially	differentially	RB	RB	_	22	advmod	_	_
24	enhanced	enhance	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	26	det	_	_
26	release	release	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	tumor	tumor	NN	NN	_	31	compound	_	_
29	necrosis	necrosis	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	alpha	alpha	NN	NN	_	26	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	TNF-alpha	tnf-alpha	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	by	by	IN	IN	_	40	case	_	_
36	the	the	DT	DT	_	40	det	_	_
37	non-Hodgkin	non-hodgkin	JJ	JJ	_	40	amod	_	_
38	's	's	POS	POS	_	40	case	_	_
39	lymphoma	lymphoma	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	26	nmod	_	_
41	Ri-I	ri-i	NN	NN	_	40	dep	_	_
42	,	,	,	,	_	41	punct	_	_
43	Ci-I	ci-i	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	41	punct	_	_
45	and	and	CC	CC	_	41	cc	_	_
46	Sc-I	sc-i	NN	NN	_	41	conj	_	_
47	,	,	,	,	_	40	punct	_	_
48	which	which	WDT	WDT	_	53	nsubj	_	_
49	are	be	VBP	VBP	_	53	cop	_	_
50	at	at	IN	IN	_	53	case	_	_
51	a	a	DT	DT	_	53	det	_	_
52	distinct	distinct	JJ	JJ	_	53	amod	_	_
53	stage	stage	NN	NN	_	40	acl:relcl	_	_
54	of	of	IN	IN	_	56	case	_	_
55	B-cell	b-cell	NN	NN	_	56	compound	_	_
56	differentiation	differentiation	NN	NN	_	53	nmod	_	_
57	,	,	,	,	_	40	punct	_	_
58	and	and	CC	CC	_	40	cc	_	_
59	by	by	IN	IN	_	66	case	_	_
60	the	the	DT	DT	_	66	det	_	_
61	more	more	RBR	RBR	_	62	advmod	_	_
62	mature	mature	JJ	JJ	_	66	amod	_	_
63	Burkitt	burkitt	NN	NN	_	66	compound	_	_
64	lymphoma	lymphoma	NN	NN	_	66	compound	_	_
65	cell	cell	NN	NN	_	66	compound	_	_
66	Raji	raji	NN	NN	_	40	conj	_	_
67	;	;	:	:	_	24	punct	_	_
68	in	in	IN	IN	_	69	case	_	_
69	contrast	contrast	NN	NN	_	74	nmod	_	_
70	,	,	,	,	_	74	punct	_	_
71	it	it	PRP	PRP	_	74	nsubj	_	_
72	did	do	VBD	VBD	_	74	aux	_	_
73	not	not	RB	RB	_	74	neg	_	_
74	induce	induce	VB	VB	_	24	parataxis	_	_
75	TNF-alpha	tnf-alpha	NN	NN	_	76	compound	_	_
76	release	release	NN	NN	_	74	dobj	_	_
77	by	by	IN	IN	_	81	case	_	_
78	the	the	DT	DT	_	81	det	_	_
79	pre-B	pre-b	JJ	JJ	_	81	amod	_	_
80	leukemia	leukemia	NN	NN	_	81	compound	_	_
81	cells	cell	NNS	NNS	_	76	nmod	_	_
82	Nalm-6	nalm-6	NN	NN	_	81	dep	_	_
83	and	and	CC	CC	_	82	cc	_	_
84	BV173	bv173	NN	NN	_	82	conj	_	_
85	.	.	.	.	_	24	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	2	compound	_	_
2	release	release	NN	NN	_	3	nsubj	_	_
3	peaked	peak	VBD	VBD	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	24	24	CD	CD	_	6	nummod	_	_
6	h	h	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	decreased	decrease	VBD	VBD	_	3	conj	_	_
9	thereafter	thereafter	RB	RB	_	8	advmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	it	it	PRP	PRP	_	15	nsubjpass	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	dose	dose	NN	NN	_	15	nmod:npmod	_	_
15	dependent	dependent	JJ	JJ	_	3	conj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	preceded	precede	VBN	VBN	_	15	conj	_	_
18	by	by	IN	IN	_	20	case	_	_
19	an	a	DT	DT	_	20	det	_	_
20	increase	increase	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	23	compound	_	_
23	mRNA	mrna	NN	NN	_	20	nmod	_	_
24	detectable	detectable	JJ	JJ	_	20	amod	_	_
25	after	after	IN	IN	_	27	case	_	_
26	3	3	CD	CD	_	27	nummod	_	_
27	h	h	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	stimulation	stimulation	NN	NN	_	27	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	mAb	mab	NN	NN	_	32	compound	_	_
32	L243	l243	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Secreted	secrete	VBN	VBN	_	2	amod	_	_
2	TNF-alpha	tnf-alpha	NN	NN	_	3	nsubj	_	_
3	mediated	mediate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	enhancement	enhancement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	activator	activator	NN	NN	_	17	compound	_	_
17	protein-1	protein-1	NN	NN	_	22	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	AP-1	ap-1	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	5	conj	_	_
23	;	;	:	:	_	3	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	fact	fact	NN	NN	_	41	nmod	_	_
26	,	,	,	,	_	41	punct	_	_
27	the	the	DT	DT	_	28	det	_	_
28	triggering	triggering	NN	NN	_	41	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	HLA-DR	hla-dr	NN	NN	_	31	compound	_	_
31	antigens	antigen	NNS	NNS	_	28	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	presence	presence	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	antihuman	antihuman	JJ	JJ	_	38	amod	_	_
37	TNF-alpha-neutralizing	tnf-alpha-neutralizing	JJ	JJ	_	38	amod	_	_
38	antibodies	antibody	NNS	NNS	_	34	nmod	_	_
39	did	do	VBD	VBD	_	41	aux	_	_
40	not	not	RB	RB	_	41	neg	_	_
41	upregulate	upregulate	VB	VB	_	3	parataxis	_	_
42	NF-kappa	nf-kappa	NN	NN	_	43	compound	_	_
43	B	b	NN	NN	_	41	dobj	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	AP-1	ap-1	NN	NN	_	43	conj	_	_
46	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	released	release	VBN	VBN	_	5	amod	_	_
5	TNF-alpha	tnf-alpha	NN	NN	_	8	nsubj	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	responsible	responsible	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	homotypic	homotypic	JJ	JJ	_	12	amod	_	_
12	aggregation	aggregation	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Ri-I	ri-i	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	Ci-I	ci-i	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	Sc-I	sc-i	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	Raji	raji	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	14	conj	_	_
23	induced	induce	VBN	VBN	_	14	acl	_	_
24	by	by	IN	IN	_	26	case	_	_
25	mAb	mab	NN	NN	_	26	compound	_	_
26	L243	l243	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	8	punct	_	_
28	and	and	CC	CC	_	8	cc	_	_
29	it	it	PRP	PRP	_	32	nsubj	_	_
30	did	do	VBD	VBD	_	32	aux	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	affect	affect	VB	VB	_	8	conj	_	_
33	the	the	DT	DT	_	34	det	_	_
34	proliferation	proliferation	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	investigated	investigate	VBN	VBN	_	37	acl	_	_
39	.	.	.	.	_	8	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	24	mark	_	_
7	:	:	:	:	_	24	punct	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	a	a	LS	LS	_	24	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	ability	ability	NN	NN	_	24	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	release	release	VB	VB	_	12	acl	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	17	dobj	_	_
19	after	after	IN	IN	_	20	case	_	_
20	triggering	triggering	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	HLA-DR	hla-dr	NN	NN	_	23	compound	_	_
23	antigens	antigen	NNS	NNS	_	20	nmod	_	_
24	depends	depend	VBZ	VBZ	_	5	ccomp	_	_
25	on	on	IN	IN	_	27	case	_	_
26	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
27	stage	stage	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	differentiation	differentiation	NN	NN	_	27	nmod	_	_
30	;	;	:	:	_	24	punct	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	b	b	LS	LS	_	38	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	levels	level	NNS	NNS	_	38	nsubj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	released	release	VBN	VBN	_	37	amod	_	_
37	TNF-alpha	tnf-alpha	NN	NN	_	34	nmod	_	_
38	seem	seem	VBP	VBP	_	24	conj	_	_
39	to	to	TO	TO	_	40	mark	_	_
40	correlate	correlate	VB	VB	_	38	xcomp	_	_
41	with	with	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	stage	stage	NN	NN	_	40	nmod	_	_
44	of	of	IN	IN	_	46	case	_	_
45	B-cell	b-cell	NN	NN	_	46	compound	_	_
46	maturation	maturation	NN	NN	_	43	nmod	_	_
47	but	but	CC	CC	_	38	cc	_	_
48	do	do	VBP	VBP	_	50	aux	_	_
49	not	not	RB	RB	_	50	neg	_	_
50	correlate	correlate	VB	VB	_	38	conj	_	_
51	with	with	IN	IN	_	53	case	_	_
52	the	the	DT	DT	_	53	det	_	_
53	amounts	amount	NNS	NNS	_	50	nmod	_	_
54	of	of	IN	IN	_	58	case	_	_
55	cell	cell	NN	NN	_	58	compound	_	_
56	surface	surface	NN	NN	_	58	compound	_	_
57	HLA-DR	hla-dr	NN	NN	_	58	compound	_	_
58	antigens	antigen	NNS	NNS	_	53	nmod	_	_
59	;	;	:	:	_	24	punct	_	_
60	(	(	-LRB-	-LRB-	_	61	punct	_	_
61	c	c	LS	LS	_	65	dep	_	_
62	)	)	-RRB-	-RRB-	_	61	punct	_	_
63	secreted	secrete	VBN	VBN	_	64	amod	_	_
64	TNF-alpha	tnf-alpha	NN	NN	_	65	nsubj	_	_
65	regulates	regulate	VBZ	VBZ	_	24	conj	_	_
66	the	the	DT	DT	_	67	det	_	_
67	levels	level	NNS	NNS	_	65	dobj	_	_
68	of	of	IN	IN	_	69	case	_	_
69	expression	expression	NN	NN	_	67	nmod	_	_
70	of	of	IN	IN	_	72	case	_	_
71	NF-kappa	nf-kappa	NN	NN	_	72	compound	_	_
72	B	b	NN	NN	_	69	nmod	_	_
73	and	and	CC	CC	_	72	cc	_	_
74	AP-1	ap-1	NN	NN	_	72	conj	_	_
75	by	by	IN	IN	_	78	case	_	_
76	an	a	DT	DT	_	78	det	_	_
77	autocrine	autocrine	JJ	JJ	_	78	amod	_	_
78	loop	loop	NN	NN	_	65	nmod	_	_
79	;	;	:	:	_	24	punct	_	_
80	and	and	CC	CC	_	24	cc	_	_
81	(	(	-LRB-	-LRB-	_	82	punct	_	_
82	d	d	LS	LS	_	93	dep	_	_
83	)	)	-RRB-	-RRB-	_	82	punct	_	_
84	intracellular	intracellular	JJ	JJ	_	85	amod	_	_
85	signals	signal	NNS	NNS	_	93	nsubj	_	_
86	mediating	mediate	VBG	VBG	_	85	acl	_	_
87	TNF-alpha	tnf-alpha	NN	NN	_	88	compound	_	_
88	release	release	NN	NN	_	86	dobj	_	_
89	by	by	IN	IN	_	91	case	_	_
90	B	b	NN	NN	_	91	compound	_	_
91	cells	cell	NNS	NNS	_	88	nmod	_	_
92	are	be	VBP	VBP	_	93	cop	_	_
93	distinct	distinct	JJ	JJ	_	24	conj	_	_
94	from	from	IN	IN	_	95	case	_	_
95	those	those	DT	DT	_	93	nmod	_	_
96	regulating	regulate	VBG	VBG	_	95	acl	_	_
97	homotypic	homotypic	JJ	JJ	_	98	amod	_	_
98	aggregation	aggregation	NN	NN	_	96	dobj	_	_
99	and	and	CC	CC	_	98	cc	_	_
100	proliferation	proliferation	NN	NN	_	98	conj	_	_
101	.	.	.	.	_	5	punct	_	_

1	Immediate	immediate	JJ	JJ	_	2	amod	_	_
2	early	early	JJ	JJ	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	early	early	JJ	JJ	_	7	amod	_	_
5	lytic	lytic	JJ	JJ	_	7	amod	_	_
6	cycle	cycle	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	2	conj	_	_
8	are	be	VBP	VBP	_	10	cop	_	_
9	frequent	frequent	JJ	JJ	_	10	amod	_	_
10	targets	target	NNS	NNS	_	0	root	_	_
11	of	of	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
14	virus-induced	virus-induced	JJ	JJ	_	18	amod	_	_
15	cytotoxic	cytotoxic	JJ	JJ	_	14	dep	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	response	response	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	a	a	DT	DT	_	9	det	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	gamma-herpesvirus	gamma-herpesvirus	NN	NN	_	2	appos	_	_
10	,	,	,	,	_	2	punct	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	establish	establish	VB	VB	_	0	root	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	nonproductive	nonproductive	JJ	JJ	_	12	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	latent	latent	JJ	JJ	_	14	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	productive	productive	JJ	JJ	_	14	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	lytic	lytic	JJ	JJ	_	19	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	infections	infection	NNS	NNS	_	14	dep	_	_
24	.	.	.	.	_	12	punct	_	_

1	Although	although	IN	IN	_	17	mark	_	_
2	the	the	DT	DT	_	10	det	_	_
3	CD8+	cd8+	JJ	JJ	_	10	amod	_	_
4	cytotoxic	cytotoxic	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CTL	ctl	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	response	response	NN	NN	_	17	nsubjpass	_	_
11	to	to	TO	TO	_	14	case	_	_
12	latently	latently	RB	RB	_	14	advmod	_	_
13	infected	infected	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	well	well	RB	RB	_	17	advmod	_	_
17	characterized	characterize	VBN	VBN	_	22	advcl	_	_
18	,	,	,	,	_	22	punct	_	_
19	very	very	RB	RB	_	20	advmod	_	_
20	little	little	JJ	JJ	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	known	know	VBN	VBN	_	0	root	_	_
23	about	about	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	controls	control	NNS	NNS	_	22	nmod	_	_
27	over	over	IN	IN	_	29	case	_	_
28	lytic	lytic	JJ	JJ	_	29	amod	_	_
29	infection	infection	NN	NN	_	26	nmod	_	_
30	;	;	:	:	_	22	punct	_	_
31	this	this	DT	DT	_	32	det	_	_
32	imbalance	imbalance	NN	NN	_	36	nsubj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	our	we	PRP$	PRP$	_	35	nmod:poss	_	_
35	understanding	understanding	NN	NN	_	32	nmod	_	_
36	belies	belie	VBZ	VBZ	_	22	parataxis	_	_
37	the	the	DT	DT	_	38	det	_	_
38	importance	importance	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	virus-replicative	virus-replicative	JJ	JJ	_	41	amod	_	_
41	lesions	lesion	NNS	NNS	_	38	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	several	several	JJ	JJ	_	44	amod	_	_
44	aspects	aspect	NNS	NNS	_	38	nmod	_	_
45	of	of	IN	IN	_	48	case	_	_
46	EBV	ebv	NN	NN	_	48	compound	_	_
47	disease	disease	NN	NN	_	48	compound	_	_
48	pathogenesis	pathogenesis	NN	NN	_	44	nmod	_	_
49	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	4	nsubj	_	_
4	shows	show	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	primary	primary	JJ	JJ	_	10	amod	_	_
8	CD8+	cd8+	JJ	JJ	_	10	amod	_	_
9	CTL	ctl	NN	NN	_	10	compound	_	_
10	response	response	NN	NN	_	17	nsubj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	EBV	ebv	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	infectious	infectious	JJ	JJ	_	16	amod	_	_
15	mononucleosis	mononucleosis	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	10	nmod	_	_
17	contains	contain	VBZ	VBZ	_	4	ccomp	_	_
18	multiple	multiple	JJ	JJ	_	21	amod	_	_
19	lytic	lytic	JJ	JJ	_	18	dep	_	_
20	antigen-specific	antigen-specific	JJ	JJ	_	18	dep	_	_
21	reactivities	reactivity	NNS	NNS	_	17	dobj	_	_
22	at	at	IN	IN	_	23	case	_	_
23	levels	level	NNS	NNS	_	21	nmod	_	_
24	at	at	IN	IN	_	25	case	_	_
25	least	least	JJS	JJS	_	27	advmod	_	_
26	as	as	RB	RB	_	27	advmod	_	_
27	high	high	JJ	JJ	_	23	amod	_	_
28	as	as	IN	IN	_	29	case	_	_
29	those	those	DT	DT	_	27	nmod	_	_
30	seen	see	VBN	VBN	_	29	acl	_	_
31	against	against	IN	IN	_	33	case	_	_
32	latent	latent	JJ	JJ	_	33	amod	_	_
33	antigens	antigen	NNS	NNS	_	30	nmod	_	_
34	;	;	:	:	_	4	punct	_	_
35	similar	similar	JJ	JJ	_	36	amod	_	_
36	reactivities	reactivity	NNS	NNS	_	39	nsubj	_	_
37	are	be	VBP	VBP	_	39	cop	_	_
38	also	also	RB	RB	_	39	advmod	_	_
39	detectable	detectable	JJ	JJ	_	4	parataxis	_	_
40	in	in	IN	IN	_	42	case	_	_
41	CTL	ctl	NN	NN	_	42	compound	_	_
42	memory	memory	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	4	punct	_	_

1	Clonal	clonal	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	individual	individual	JJ	JJ	_	5	amod	_	_
5	responses	response	NNS	NNS	_	3	dobj	_	_
6	to	to	TO	TO	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	immediate	immediate	JJ	JJ	_	11	amod	_	_
10	early	early	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	5	nmod	_	_
12	BZLF1	bzlf1	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	BRLF1	brlf1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	to	to	TO	TO	_	18	case	_	_
18	three	three	CD	CD	_	11	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	BMLF1	bmlf1	NN	NN	_	18	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	BMRF1	bmrf1	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	BALF2	balf2	NN	NN	_	20	conj	_	_
26	)	)	-RRB-	-RRB-	_	20	punct	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	six	six	CD	CD	_	31	nummod	_	_
30	early	early	JJ	JJ	_	31	amod	_	_
31	proteins	protein	NNS	NNS	_	11	nmod	_	_
32	tested	test	VBN	VBN	_	31	acl	_	_
33	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	several	several	JJ	JJ	_	3	amod	_	_
3	cases	case	NNS	NNS	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	peptide	peptide	NN	NN	_	7	compound	_	_
7	epitope	epitope	NN	NN	_	17	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	HLA-restricting	hla-restricting	JJ	JJ	_	10	amod	_	_
10	determinant	determinant	NN	NN	_	7	conj	_	_
11	recognized	recognize	VBN	VBN	_	7	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	CTLs	ctl	NNS	NNS	_	11	nmod	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	defined	define	VBN	VBN	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	one	one	CD	CD	_	21	nummod	_	_
20	unusual	unusual	JJ	JJ	_	21	amod	_	_
21	feature	feature	NN	NN	_	24	nsubj	_	_
22	being	be	VBG	VBG	_	24	cop	_	_
23	the	the	DT	DT	_	24	det	_	_
24	number	number	NN	NN	_	17	advcl	_	_
25	of	of	IN	IN	_	26	case	_	_
26	responses	response	NNS	NNS	_	24	nmod	_	_
27	restricted	restricted	JJ	JJ	_	26	amod	_	_
28	through	through	IN	IN	_	30	case	_	_
29	HLA-C	hla-c	NN	NN	_	30	compound	_	_
30	alleles	allele	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	work	work	NN	NN	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggests	suggest	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	EBV-replicative	ebv-replicative	JJ	JJ	_	7	amod	_	_
7	lesions	lesion	NNS	NNS	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	subject	subject	JJ	JJ	_	4	ccomp	_	_
10	to	to	TO	TO	_	13	case	_	_
11	direct	direct	JJ	JJ	_	13	amod	_	_
12	CTL	ctl	NN	NN	_	13	compound	_	_
13	control	control	NN	NN	_	9	nmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	9	advmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	that	that	IN	IN	_	27	mark	_	_
18	immediate	immediate	JJ	JJ	_	19	amod	_	_
19	early	early	JJ	JJ	_	27	nsubj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	early	early	JJ	JJ	_	19	conj	_	_
22	proteins	protein	NNS	NNS	_	19	dep	_	_
23	are	be	VBP	VBP	_	27	cop	_	_
24	frequently	frequently	RB	RB	_	27	advmod	_	_
25	the	the	DT	DT	_	27	det	_	_
26	immunodominant	immunodominant	JJ	JJ	_	27	amod	_	_
27	targets	target	NNS	NNS	_	9	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	contrasts	contrast	VBZ	VBZ	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	findings	finding	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	alpha-	alpha-	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	beta-herpesvirus	beta-herpesvirus	NN	NN	_	6	conj	_	_
9	systems	system	NNS	NNS	_	6	dep	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	herpes	herpes	NN	NN	_	12	compound	_	_
12	simplex	simplex	NN	NN	_	6	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	cytomegalovirus	cytomegalovirus	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	where	where	WRB	WRB	_	26	advmod	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	interference	interference	NN	NN	_	26	nsubj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	antigen-processing	antigen-processing	JJ	JJ	_	22	amod	_	_
22	pathway	pathway	NN	NN	_	18	nmod	_	_
23	during	during	IN	IN	_	25	case	_	_
24	lytic	lytic	JJ	JJ	_	25	amod	_	_
25	infection	infection	NN	NN	_	18	nmod	_	_
26	renders	render	VBZ	VBZ	_	6	acl:relcl	_	_
27	immediate	immediate	JJ	JJ	_	28	amod	_	_
28	early	early	JJ	JJ	_	34	nsubj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	early	early	JJ	JJ	_	28	conj	_	_
31	proteins	protein	NNS	NNS	_	28	dep	_	_
32	much	much	RB	RB	_	33	advmod	_	_
33	less	less	RBR	RBR	_	34	advmod	_	_
34	immunogenic	immunogenic	JJ	JJ	_	26	xcomp	_	_
35	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	unique	unique	JJ	JJ	_	3	amod	_	_
3	capacity	capacity	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	gamma-herpesvirus	gamma-herpesvirus	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	amplify	amplify	VB	VB	_	3	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	load	load	NN	NN	_	7	dobj	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vivo	vivo	FW	FW	_	7	advmod	_	_
13	through	through	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	latent	latent	JJ	JJ	_	17	amod	_	_
16	growth-transforming	growth-transforming	JJ	JJ	_	15	dep	_	_
17	infection	infection	NN	NN	_	7	nmod	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	have	have	VB	VB	_	20	aux	_	_
20	rendered	render	VBN	VBN	_	0	root	_	_
21	these	these	DT	DT	_	22	det	_	_
22	agents	agent	NNS	NNS	_	24	nsubj	_	_
23	less	less	RBR	RBR	_	24	advmod	_	_
24	dependent	dependent	JJ	JJ	_	20	xcomp	_	_
25	upon	upon	IN	IN	_	27	case	_	_
26	viral	viral	JJ	JJ	_	27	amod	_	_
27	replication	replication	NN	NN	_	24	nmod	_	_
28	as	as	IN	IN	_	30	case	_	_
29	a	a	DT	DT	_	30	det	_	_
30	means	means	NN	NN	_	20	nmod	_	_
31	of	of	IN	IN	_	33	mark	_	_
32	successfully	successfully	RB	RB	_	33	advmod	_	_
33	colonizing	colonize	VBG	VBG	_	30	acl	_	_
34	their	they	PRP$	PRP$	_	35	nmod:poss	_	_
35	hosts	host	NNS	NNS	_	33	dobj	_	_
36	.	.	.	.	_	20	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	new	new	JJ	JJ	_	4	amod	_	_
3	mouse	mouse	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	17	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	SRG3	srg3	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	related	related	JJ	JJ	_	4	amod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	SWI3	swi3	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Saccharomyces	saccharomyces	FW	FW	_	14	compound	_	_
14	cerevisiae	cerevisiae	FW	FW	_	11	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	0	root	_	_
18	for	for	IN	IN	_	19	case	_	_
19	apoptosis	apoptosis	NN	NN	_	17	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	glucocorticoids	glucocorticoid	NNS	NNS	_	20	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	thymoma	thymoma	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	line	line	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	isolated	isolate	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	new	new	JJ	JJ	_	6	amod	_	_
5	mouse	mouse	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	dobj	_	_
7	that	that	WDT	WDT	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	highly	highly	RB	RB	_	10	advmod	_	_
10	expressed	express	VBN	VBN	_	6	acl:relcl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	thymocytes	thymocyte	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	testis	testis	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	brain	brain	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	6	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	SRG3	srg3	NN	NN	_	2	appos	_	_
5	,	,	,	,	_	2	punct	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	significant	significant	JJ	JJ	_	10	amod	_	_
9	sequence	sequence	NN	NN	_	10	compound	_	_
10	homology	homology	NN	NN	_	6	dobj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	SWI3	swi3	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	17	det	_	_
15	yeast	yeast	NN	NN	_	17	compound	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activator	activator	NN	NN	_	12	appos	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	homolog	homolog	NN	NN	_	23	compound	_	_
23	BAF155	baf155	NN	NN	_	12	conj	_	_
24	.	.	.	.	_	6	punct	_	_

1	SRG3	srg3	NN	NN	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	1,100	1,100	CD	CD	_	5	nummod	_	_
4	amino	amino	NN	NN	_	5	compound	_	_
5	acids	acid	NNS	NNS	_	2	dobj	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	has	have	VBZ	VBZ	_	2	conj	_	_
8	33-47	33-47	CD	CD	_	9	dep	_	_
9	%	%	NN	NN	_	10	dep	_	_
10	identity	identity	NN	NN	_	7	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	SWI3	swi3	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	10	nmod	_	_
14	over	over	IN	IN	_	16	case	_	_
15	three	three	CD	CD	_	16	nummod	_	_
16	regions	region	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	SRG3	srg3	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	8	det	_	_
6	acidic	acidic	JJ	JJ	_	8	amod	_	_
7	NH2	nh2	NN	NN	_	8	compound	_	_
8	terminus	terminus	NN	NN	_	4	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	14	det	_	_
11	myb-like	myb-like	JJ	JJ	_	14	amod	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	a	a	DT	DT	_	18	det	_	_
17	leucine-zipper	leucine-zipper	JJ	JJ	_	18	amod	_	_
18	motif	motif	NN	NN	_	8	conj	_	_
19	,	,	,	,	_	8	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	a	a	DT	DT	_	25	det	_	_
22	proline-	proline-	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	glutamine-rich	glutamine-rich	JJ	JJ	_	22	conj	_	_
25	region	region	NN	NN	_	8	conj	_	_
26	at	at	IN	IN	_	29	case	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	COOH	cooh	NN	NN	_	29	compound	_	_
29	terminus	terminus	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Rabbit	rabbit	NN	NN	_	2	compound	_	_
2	antiserum	antiserum	NN	NN	_	11	nsubj	_	_
3	raised	raise	VBN	VBN	_	2	acl	_	_
4	against	against	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	COOH-terminal	cooh-terminal	JJ	JJ	_	7	amod	_	_
7	polypeptide	polypeptide	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	SRG3	srg3	NN	NN	_	7	nmod	_	_
11	recognized	recognize	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	13	det	_	_
13	protein	protein	NN	NN	_	11	dobj	_	_
14	with	with	IN	IN	_	18	case	_	_
15	an	a	DT	DT	_	18	det	_	_
16	apparent	apparent	JJ	JJ	_	18	amod	_	_
17	molecular	molecular	JJ	JJ	_	18	amod	_	_
18	mass	mass	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	155	155	CD	CD	_	21	nummod	_	_
21	kD	kd	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	serum	serum	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	detected	detect	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	170-kD	170-kd	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	4	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	seems	seem	VBZ	VBZ	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	14	mark	_	_
11	be	be	VB	VB	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	mouse	mouse	NN	NN	_	14	compound	_	_
14	homologue	homologue	NN	NN	_	9	xcomp	_	_
15	of	of	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	BAF170	baf170	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Immunoprecipitation	immunoprecipitation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	extract	extract	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	antiserum	antiserum	NN	NN	_	1	nmod	_	_
8	against	against	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	mouse	mouse	NN	NN	_	11	compound	_	_
11	SRG3	srg3	NN	NN	_	7	nmod	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	brought	bring	VBD	VBD	_	0	root	_	_
14	down	down	RP	RP	_	13	compound:prt	_	_
15	a	a	DT	DT	_	17	det	_	_
16	195-kD	195-kd	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	13	dobj	_	_
18	that	that	WDT	WDT	_	21	nsubjpass	_	_
19	could	could	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	recognized	recognize	VBN	VBN	_	17	acl:relcl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	an	a	DT	DT	_	24	det	_	_
24	antiserum	antiserum	NN	NN	_	21	nmod	_	_
25	raised	raise	VBN	VBN	_	24	acl	_	_
26	against	against	IN	IN	_	29	case	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	SWI2	swi2	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	SRG3	srg3	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	8	nsubj	_	_
8	associates	associate	VBZ	VBZ	_	3	ccomp	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	mouse	mouse	NN	NN	_	12	compound	_	_
12	SWI2	swi2	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	SRG3	srg3	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	about	about	RB	RB	_	8	advmod	_	_
7	three	three	CD	CD	_	8	compound	_	_
8	times	time	NNS	NNS	_	9	dep	_	_
9	higher	higher	JJR	JJR	_	5	advmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	thymocytes	thymocyte	NNS	NNS	_	9	nmod	_	_
12	than	than	IN	IN	_	15	case	_	_
13	in	in	IN	IN	_	15	case	_	_
14	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	anti-sense	anti-sense	JJ	JJ	_	5	amod	_	_
5	RNA	rna	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	SRG3	srg3	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	thymoma	thymoma	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	2	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	S49.1	s49.1	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	2	punct	_	_
17	reduced	reduce	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	20	det	_	_
19	expression	expression	NN	NN	_	20	compound	_	_
20	level	level	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	SRG3	srg3	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	17	punct	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	decreased	decrease	VBD	VBD	_	17	conj	_	_
28	the	the	DT	DT	_	31	det	_	_
29	apoptotic	apoptotic	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	death	death	NN	NN	_	27	dobj	_	_
32	induced	induce	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	34	case	_	_
34	glucocorticoids	glucocorticoid	NNS	NNS	_	32	nmod	_	_
35	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	SRG3	srg3	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	3	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	13	amod	_	_
13	apoptosis	apoptosis	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	thymoma	thymoma	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	implicates	implicate	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	SRG3	srg3	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	play	play	VB	VB	_	2	ccomp	_	_
8	an	a	DT	DT	_	11	det	_	_
9	important	important	JJ	JJ	_	11	amod	_	_
10	regulatory	regulatory	JJ	JJ	_	9	dep	_	_
11	role	role	NN	NN	_	7	dobj	_	_
12	during	during	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	development	development	NN	NN	_	7	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	thymus	thymus	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Cytomegalovirus	cytomegalovirus	NN	NN	_	4	compound	_	_
2	immediate	immediate	JJ	JJ	_	4	amod	_	_
3	early	early	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	5	nsubj	_	_
5	upregulate	upregulate	VBP	VBP	_	0	root	_	_
6	interleukin-6	interleukin-6	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	6	det	_	_
4	immediate	immediate	JJ	JJ	_	6	amod	_	_
5	early	early	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	18	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IE	ie	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	cytomegalovirus	cytomegalovirus	NN	NN	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	CMV	cmv	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	can	can	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	expressed	express	VBN	VBN	_	1	dep	_	_
19	in	in	IN	IN	_	21	case	_	_
20	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	known	know	VBN	VBN	_	18	conj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	regulate	regulate	VB	VB	_	24	xcomp	_	_
27	viral	viral	JJ	JJ	_	26	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	cellular	cellular	JJ	JJ	_	27	conj	_	_
30	genes	gene	NNS	NNS	_	27	dep	_	_
31	.	.	.	.	_	18	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-6	il-6	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	plays	play	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	central	central	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	numerous	numerous	JJ	JJ	_	11	amod	_	_
11	inflammatory	inflammatory	JJ	JJ	_	5	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	immune	immune	JJ	JJ	_	11	conj	_	_
14	processes	process	NNS	NNS	_	11	dep	_	_
15	.	.	.	.	_	5	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	increased	increase	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	lung	lung	NN	NN	_	8	compound	_	_
7	transplant	transplant	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	4	nmod	_	_
9	clinically	clinically	RB	RB	_	10	advmod	_	_
10	diagnosed	diagnose	VBN	VBN	_	8	acl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	CMV	cmv	NN	NN	_	13	compound	_	_
13	pneumonitis	pneumonitis	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IL-6	il-6	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	dependent	dependent	JJ	JJ	_	0	root	_	_
7	on	on	IN	IN	_	9	case	_	_
8	various	various	JJ	JJ	_	9	amod	_	_
9	stimuli	stimulus	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	include	include	VBP	VBP	_	9	acl:relcl	_	_
12	lipopolysaccharide	lipopolysaccharide	NN	NN	_	11	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LPS	lps	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	12	punct	_	_
17	viruses	virus	NNS	NNS	_	12	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	other	other	JJ	JJ	_	21	amod	_	_
21	cytokines	cytokine	NNS	NNS	_	12	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ability	ability	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	CMV	cmv	NN	NN	_	10	compound	_	_
8	IE	ie	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	products	product	NNS	NNS	_	5	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	modulate	modulate	VB	VB	_	5	acl	_	_
13	IL-6	il-6	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	THP-1	thp-1	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	4	appos	_	_
10	,	,	,	,	_	4	punct	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	transfected	transfect	VBN	VBN	_	1	dep	_	_
13	with	with	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	CMV	cmv	NN	NN	_	17	compound	_	_
16	IE	ie	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	7	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IL-6	il-6	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	conj	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	measured	measure	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	control	control	JJ	JJ	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CMV	cmv	NN	NN	_	15	compound	_	_
12	immediate	immediate	JJ	JJ	_	15	amod	_	_
13	early	early	JJ	JJ	_	15	amod	_	_
14	transfected	transfect	VBN	VBN	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	9	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	19	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	CMV	cmv	NN	NN	_	5	compound	_	_
4	IE	ie	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-6	il-6	NN	NN	_	5	conj	_	_
8	chloramphenicol	chloramphenicol	NN	NN	_	10	compound	_	_
9	acetyl	acetyl	NN	NN	_	10	compound	_	_
10	transferase	transferase	NN	NN	_	7	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CAT	cat	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	or	or	CC	CC	_	7	cc	_	_
15	IL-6	il-6	NN	NN	_	16	compound	_	_
16	luciferase	luciferase	NN	NN	_	7	conj	_	_
17	constructs	construct	NNS	NNS	_	7	dep	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	used	use	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	study	study	VB	VB	_	19	xcomp	_	_
22	IL-6	il-6	NN	NN	_	24	compound	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	19	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Interleukin-6	interleukin-6	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	4	conj	_	_
8	were	be	VBD	VBD	_	10	auxpass	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	increased	increase	VBN	VBN	_	1	dep	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	transfected	transfect	VBN	VBN	_	12	dep	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	CMV	cmv	NN	NN	_	18	compound	_	_
17	IE	ie	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	stimulated	stimulate	VBN	VBN	_	13	conj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	LPS	lps	NN	NN	_	20	nmod	_	_
23	compared	compare	VBN	VBN	_	27	case	_	_
24	to	to	TO	TO	_	27	case	_	_
25	LPS-stimulated	lps-stimulated	JJ	JJ	_	27	amod	_	_
26	control	control	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	10	advcl	_	_
28	.	.	.	.	_	1	punct	_	_

1	Cytomegalovirus	cytomegalovirus	NN	NN	_	4	compound	_	_
2	IE	ie	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	products	product	NNS	NNS	_	6	nsubj	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	enhanced	enhance	VBD	VBD	_	0	root	_	_
7	LPS	lps	NN	NN	_	8	compound	_	_
8	stimulation	stimulation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	IL-6	il-6	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	IL-6	il-6	NN	NN	_	16	compound	_	_
16	CAT	cat	NN	NN	_	6	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-6	il-6	NN	NN	_	19	compound	_	_
19	luciferase	luciferase	NN	NN	_	16	conj	_	_
20	assays	assay	NNS	NNS	_	16	dep	_	_
21	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	construct	construct	NN	NN	_	17	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	3	acl:relcl	_	_
6	a	a	DT	DT	_	9	det	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	5	dobj	_	_
10	but	but	CC	CC	_	5	cc	_	_
11	is	be	VBZ	VBZ	_	12	aux	_	_
12	missing	miss	VBG	VBG	_	5	conj	_	_
13	the	the	DT	DT	_	16	det	_	_
14	multiple	multiple	JJ	JJ	_	16	amod	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	12	dobj	_	_
17	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	continued	continued	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	IL-6	il-6	NN	NN	_	24	compound	_	_
23	luciferase	luciferase	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	LPS-stimulated	lps-stimulated	JJ	JJ	_	29	amod	_	_
27	CMV	cmv	NN	NN	_	29	compound	_	_
28	transfected	transfected	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Cytomegalovirus	cytomegalovirus	NN	NN	_	7	compound	_	_
4	immediate	immediate	JJ	JJ	_	7	amod	_	_
5	early	early	JJ	JJ	_	7	amod	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	products	product	NNS	NNS	_	9	nsubj	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	enhanced	enhance	VBD	VBD	_	1	dep	_	_
10	expression	expression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-6	il-6	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	LPS-stimulated	lps-stimulated	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	IL-6	il-6	NN	NN	_	6	compound	_	_
5	luciferase	luciferase	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	occurs	occur	VBZ	VBZ	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	absence	absence	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	multiple	multiple	JJ	JJ	_	15	amod	_	_
14	response	response	NN	NN	_	15	compound	_	_
15	region	region	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	area	area	NN	NN	_	15	appos	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-6	il-6	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	responsive	responsive	JJ	JJ	_	18	amod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	IL-1	il-1	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	TNF	tnf	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	25	conj	_	_
29	,	,	,	,	_	25	punct	_	_
30	cyclic	cyclic	JJ	JJ	_	31	amod	_	_
31	amp	amp	NN	NN	_	25	conj	_	_
32	,	,	,	,	_	25	punct	_	_
33	and	and	CC	CC	_	25	cc	_	_
34	phorbol	phorbol	NN	NN	_	36	compound	_	_
35	12-myristate	12-myristate	NN	NN	_	36	compound	_	_
36	13-acetate	13-acetate	NN	NN	_	25	conj	_	_
37	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	CMV	cmv	NN	NN	_	7	compound	_	_
5	IE	ie	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	products	product	NNS	NNS	_	2	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	enhance	enhance	VB	VB	_	2	acl	_	_
10	IL-6	il-6	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	9	dobj	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	play	play	VB	VB	_	0	root	_	_
14	an	a	DT	DT	_	16	det	_	_
15	important	important	JJ	JJ	_	16	amod	_	_
16	role	role	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	inflammatory	inflammatory	JJ	JJ	_	20	amod	_	_
20	states	state	NNS	NNS	_	13	nmod	_	_
21	associated	associate	VBN	VBN	_	20	acl	_	_
22	with	with	IN	IN	_	24	case	_	_
23	CMV	cmv	NN	NN	_	24	compound	_	_
24	infection	infection	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Cellular	cellular	JJ	JJ	_	3	amod	_	_
2	redox	redox	NN	NN	_	3	compound	_	_
3	status	status	NN	NN	_	4	nsubj	_	_
4	influences	influence	VBZ	VBZ	_	0	root	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	cytotoxic	cytotoxic	JJ	JJ	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	conj	_	_
10	activation	activation	NN	NN	_	6	dep	_	_
11	in	in	IN	IN	_	14	case	_	_
12	natural	natural	JJ	JJ	_	14	amod	_	_
13	killer	killer	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	23	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cellular	cellular	JJ	JJ	_	6	amod	_	_
5	redox	redox	NN	NN	_	6	compound	_	_
6	status	status	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	cytotoxic	cytotoxic	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	10	conj	_	_
15	in	in	IN	IN	_	21	case	_	_
16	natural	natural	JJ	JJ	_	21	amod	_	_
17	killer	killer	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	NK	nk	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	cells	cell	NNS	NNS	_	10	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	investigated	investigate	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	30	mark	_	_
5	stimulation	stimulation	NN	NN	_	30	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NK	nk	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	either	either	CC	CC	_	8	dep	_	_
11	freshly	freshly	RB	RB	_	12	advmod	_	_
12	isolated	isolate	VBN	VBN	_	10	dep	_	_
13	from	from	IN	IN	_	16	case	_	_
14	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
15	blood	blood	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PBL	pbl	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	or	or	CC	CC	_	10	cc	_	_
21	long-term	long-term	JJ	JJ	_	24	amod	_	_
22	cultured	culture	VBN	VBN	_	24	amod	_	_
23	NK	nk	NN	NN	_	24	compound	_	_
24	clones	clone	NNS	NNS	_	10	conj	_	_
25	,	,	,	,	_	5	punct	_	_
26	with	with	IN	IN	_	29	case	_	_
27	specific	specific	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	targets	target	NNS	NNS	_	5	nmod	_	_
30	results	result	VBZ	VBZ	_	3	ccomp	_	_
31	in	in	IN	IN	_	35	case	_	_
32	an	a	DT	DT	_	35	det	_	_
33	increased	increase	VBN	VBN	_	35	amod	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	30	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	35	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	AP-1	ap-1	NN	NN	_	38	conj	_	_
41	transcription	transcription	NN	NN	_	42	compound	_	_
42	factors	factor	NNS	NNS	_	38	dep	_	_
43	measured	measure	VBN	VBN	_	35	acl	_	_
44	by	by	IN	IN	_	46	case	_	_
45	gel	gel	NN	NN	_	46	compound	_	_
46	retardation	retardation	NN	NN	_	43	nmod	_	_
47	.	.	.	.	_	3	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NK	nk	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	antioxidant	antioxidant	JJ	JJ	_	1	nmod	_	_
8	pyrrolidine	pyrrolidine	NN	NN	_	9	compound	_	_
9	dithiocarbarmate	dithiocarbarmate	NN	NN	_	7	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	PDTC	pdtc	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	leads	lead	VBZ	VBZ	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	inhibition	inhibition	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	but	but	CC	CC	_	13	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	AP-1	ap-1	NN	NN	_	24	compound	_	_
24	binding	binding	NN	NN	_	28	nsubjpass	_	_
25	to	to	TO	TO	_	26	case	_	_
26	DNA	dna	NN	NN	_	24	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	superinduced	superinduce	VBN	VBN	_	13	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	PDTC	pdtc	NN	NN	_	2	nmod	_	_
8	paralleled	parallel	VBD	VBD	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	an	a	DT	DT	_	11	det	_	_
11	inhibition	inhibition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	spontaneous	spontaneous	JJ	JJ	_	14	amod	_	_
14	cytotoxicity	cytotoxicity	NN	NN	_	11	nmod	_	_
15	mediated	mediate	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	NK	nk	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	inhibitors	inhibitor	NNS	NNS	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	serine	serine	NN	NN	_	7	compound	_	_
7	proteases	protease	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	N-alpha-tosyl-L-lysine	n-alpha-tosyl-l-lysine	NN	NN	_	11	compound	_	_
10	chloromethyl	chloromethyl	NN	NN	_	11	compound	_	_
11	ketone	ketone	NN	NN	_	4	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	N-alpha-tosyl-L-phenylalanine	n-alpha-tosyl-l-phenylalanine	NN	NN	_	15	compound	_	_
14	chloromethyl	chloromethyl	NN	NN	_	15	compound	_	_
15	ketone	ketone	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	blocked	block	VBD	VBD	_	0	root	_	_
19	the	the	DT	DT	_	21	det	_	_
20	cytolytic	cytolytic	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NK	nk	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	against	against	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	sensitive	sensitive	JJ	JJ	_	28	amod	_	_
28	target	target	NN	NN	_	18	nmod	_	_
29	K562	k562	NN	NN	_	28	dep	_	_
30	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	NK	nk	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	affected	affect	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	pretreatment	pretreatment	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	effector	effector	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	proteasome	proteasome	NN	NN	_	18	compound	_	_
18	inhibitor	inhibitor	NN	NN	_	10	nmod	_	_
19	N-acetyl-leu-leu-norleucinal	n-acetyl-leu-leu-norleucinal	NN	NN	_	18	dep	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	selectively	selectively	RB	RB	_	22	advmod	_	_
22	inhibits	inhibit	VBZ	VBZ	_	18	acl:relcl	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	8	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	support	support	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	hypothesis	hypothesis	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NK	nk	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	involved	involve	VBD	VBD	_	7	ccomp	_	_
15	transcriptional	transcriptional	JJ	JJ	_	14	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	post-transcriptional	post-transcriptional	JJ	JJ	_	15	conj	_	_
18	events	event	NNS	NNS	_	15	dep	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	reactive	reactive	JJ	JJ	_	23	amod	_	_
23	intermediates	intermediate	NNS	NNS	_	25	nsubj	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	play	play	VB	VB	_	14	conj	_	_
26	an	a	DT	DT	_	28	det	_	_
27	important	important	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	molecular	molecular	JJ	JJ	_	32	amod	_	_
32	processes	process	NNS	NNS	_	25	nmod	_	_
33	related	related	JJ	JJ	_	32	amod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	generation	generation	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	cytotoxic	cytotoxic	JJ	JJ	_	40	amod	_	_
40	response	response	NN	NN	_	36	nmod	_	_
41	by	by	IN	IN	_	43	case	_	_
42	NK	nk	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	36	nmod	_	_
44	.	.	.	.	_	5	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	4	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocyte	lymphocyte	NN	NN	_	4	compound	_	_
4	development	development	NN	NN	_	0	root	_	_
5	induced	induce	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	targeted	target	VBN	VBN	_	8	amod	_	_
8	overexpression	overexpression	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IkappaB	ikappab	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	thymic	thymic	JJ	JJ	_	5	amod	_	_
5	maturation	maturation	NN	NN	_	2	nmod	_	_
6	for	for	IN	IN	_	7	case	_	_
7	factors	factor	NNS	NNS	_	2	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	family	family	NN	NN	_	7	nmod	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	long	long	RB	RB	_	15	advmod	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	suspected	suspect	VBN	VBN	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	15	cc	_	_
18	not	not	RB	RB	_	19	dep	_	_
19	yet	yet	RB	RB	_	20	advmod	_	_
20	proven	prove	VBN	VBN	_	15	conj	_	_
21	.	.	.	.	_	15	punct	_	_

1	Transgenic	transgenic	JJ	JJ	_	2	amod	_	_
2	mice	mouse	NNS	NNS	_	11	nsubjpass	_	_
3	with	with	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	6	amod	_	_
6	defect	defect	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	produced	produce	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	targeted	target	VBN	VBN	_	14	amod	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	IkappaB	ikappab	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	thymic	thymic	JJ	JJ	_	3	amod	_	_
3	cellularity	cellularity	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	mice	mouse	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	decreased	decrease	VBN	VBN	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proportion	proportion	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	mature	mature	JJ	JJ	_	7	amod	_	_
5	,	,	,	,	_	7	punct	_	_
6	TCRhigh	tcrhigh	JJ	JJ	_	7	amod	_	_
7	thymocytes	thymocyte	NNS	NNS	_	2	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	alphabeta	alphabeta	NN	NN	_	11	compound	_	_
11	lineage	lineage	NN	NN	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	reduced	reduce	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	remaining	remain	VBG	VBG	_	19	amod	_	_
18	TCRhigh	tcrhigh	JJ	JJ	_	19	amod	_	_
19	population	population	NN	NN	_	20	nsubj	_	_
20	contained	contain	VBD	VBD	_	13	conj	_	_
21	an	a	DT	DT	_	24	det	_	_
22	unusually	unusually	RB	RB	_	23	advmod	_	_
23	high	high	JJ	JJ	_	24	amod	_	_
24	proportion	proportion	NN	NN	_	20	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	double-positive	double-positive	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	defect	defect	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	maturation	maturation	NN	NN	_	2	nmod	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	transgene	transgene	NN	NN	_	10	compound	_	_
9	dose-dependent	dose-dependent	JJ	JJ	_	10	amod	_	_
10	reduction	reduction	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	with	with	IN	IN	_	23	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	CD8	cd8	NN	NN	_	19	compound	_	_
19	lineage	lineage	NN	NN	_	23	nsubjpass	_	_
20	being	be	VBG	VBG	_	23	auxpass	_	_
21	more	more	RBR	RBR	_	22	advmod	_	_
22	severely	severely	RB	RB	_	23	advmod	_	_
23	affected	affect	VBN	VBN	_	5	advcl	_	_
24	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	involvement	involvement	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	12	compound	_	_
11	family	family	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	late	late	JJ	JJ	_	15	amod	_	_
15	stages	stage	NNS	NNS	_	8	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	development	development	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	3	punct	_	_
21	coincident	coincident	JJ	JJ	_	3	advmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	positive	positive	JJ	JJ	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	negative	negative	JJ	JJ	_	23	conj	_	_
26	selection	selection	NN	NN	_	23	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	Sequential	sequential	JJ	JJ	_	2	amod	_	_
2	development	development	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	structural	structural	JJ	JJ	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	functional	functional	JJ	JJ	_	4	conj	_	_
7	alterations	alteration	NNS	NNS	_	4	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	tumor-bearing	tumor-bearing	NN	NN	_	13	compound	_	_
13	mice	mouse	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	TCR	tcr	NN	NN	_	9	nsubj	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	beta	beta	NN	NN	_	2	dep	_	_
5	or	or	CC	CC	_	2	cc	_	_
6	-gamma	-gamma	NN	NN	_	7	compound	_	_
7	delta	delta	NN	NN	_	2	conj	_	_
8	chains	chain	NNS	NNS	_	2	dep	_	_
9	bind	bind	VBP	VBP	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	peptide	peptide	NN	NN	_	12	compound	_	_
12	ligand	ligand	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	9	punct	_	_
14	whereas	whereas	IN	IN	_	25	mark	_	_
15	the	the	DT	DT	_	20	dep	_	_
16	associated	associate	VBN	VBN	_	20	amod	_	_
17	CD3	cd3	NN	NN	_	20	compound	_	_
18	delta	delta	NN	NN	_	20	compound	_	_
19	epsilon	epsilon	NN	NN	_	20	compound	_	_
20	gamma	gamma	NN	NN	_	25	nsubj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	TCR	tcr	NN	NN	_	24	compound	_	_
23	zeta	zeta	NN	NN	_	24	compound	_	_
24	subunits	subunit	NNS	NNS	_	20	conj	_	_
25	couple	couple	VBP	VBP	_	9	advcl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	TCR	tcr	NN	NN	_	25	dobj	_	_
28	to	to	TO	TO	_	32	case	_	_
29	intracellular	intracellular	JJ	JJ	_	32	amod	_	_
30	signal	signal	NN	NN	_	32	compound	_	_
31	transduction	transduction	NN	NN	_	32	compound	_	_
32	components	component	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	Recently	recently	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	several	several	JJ	JJ	_	4	amod	_	_
4	groups	group	NNS	NNS	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	described	describe	VBN	VBN	_	0	root	_	_
7	marked	marked	JJ	JJ	_	8	amod	_	_
8	alterations	alteration	NNS	NNS	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	signal	signal	NN	NN	_	12	compound	_	_
11	transduction	transduction	NN	NN	_	12	compound	_	_
12	elements	element	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	cancer	cancer	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	15	nmod	_	_
19	or	or	CC	CC	_	15	cc	_	_
20	in	in	IN	IN	_	21	case	_	_
21	mice	mouse	NNS	NNS	_	15	conj	_	_
22	bearing	bear	VBG	VBG	_	21	acl	_	_
23	tumor	tumor	NN	NN	_	22	dobj	_	_
24	for	for	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	few	few	JJ	JJ	_	27	amod	_	_
27	weeks	week	NNS	NNS	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	&gt;	&gt;	JJR	JJR	_	27	dep	_	_
30	26	26	CD	CD	_	31	nummod	_	_
31	days	day	NNS	NNS	_	29	nmod:tmod	_	_
32	)	)	-RRB-	-RRB-	_	29	punct	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	9	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	7	nmod	_	_
5	these	these	DT	DT	_	6	det	_	_
6	alterations	alteration	NNS	NNS	_	7	nsubj	_	_
7	develop	develop	VBP	VBP	_	2	acl:relcl	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	unknown	unknown	JJ	JJ	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	explore	explore	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	kinetics	kinetics	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	development	development	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	alterations	alteration	NNS	NNS	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	signal	signal	NN	NN	_	19	compound	_	_
18	transduction	transduction	NN	NN	_	19	compound	_	_
19	molecules	molecule	NNS	NNS	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	TCR	tcr	NN	NN	_	23	compound	_	_
22	zeta	zeta	NN	NN	_	23	compound	_	_
23	chain	chain	NN	NN	_	19	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	NF	nf	NN	NN	_	28	compound	_	_
26	kappaB	kappab	NN	NN	_	28	compound	_	_
27	family	family	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	23	conj	_	_
29	,	,	,	,	_	23	punct	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	tyrosine	tyrosine	NN	NN	_	35	compound	_	_
32	kinase	kinase	NN	NN	_	35	compound	_	_
33	p56	p56	NN	NN	_	35	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	lck	lck	NN	NN	_	23	conj	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	)	)	-RRB-	-RRB-	_	23	punct	_	_
38	in	in	IN	IN	_	39	case	_	_
39	mice	mouse	NNS	NNS	_	19	nmod	_	_
40	bearing	bear	VBG	VBG	_	39	acl	_	_
41	MC38	mc38	NN	NN	_	43	compound	_	_
42	colon	colon	NN	NN	_	43	compound	_	_
43	adenocarcinoma	adenocarcinoma	NN	NN	_	40	dobj	_	_
44	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	alterations	alteration	NNS	NNS	_	22	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	NF	nf	NN	NN	_	10	compound	_	_
8	kappaB	kappab	NN	NN	_	10	compound	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	specifically	specifically	RB	RB	_	14	advmod	_	_
13	the	the	DT	DT	_	14	det	_	_
14	failure	failure	NN	NN	_	5	appos	_	_
15	of	of	IN	IN	_	17	case	_	_
16	p65	p65	NN	NN	_	17	compound	_	_
17	translocation	translocation	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nucleus	nucleus	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	occur	occur	VBP	VBP	_	3	ccomp	_	_
23	earlier	earlier	RBR	RBR	_	24	advmod	_	_
24	and	and	CC	CC	_	22	advmod	_	_
25	more	more	RBR	RBR	_	26	advmod	_	_
26	frequently	frequently	RB	RB	_	24	advmod	_	_
27	than	than	IN	IN	_	29	mark	_	_
28	the	the	DT	DT	_	29	det	_	_
29	decrease	decrease	NN	NN	_	24	advcl	_	_
30	in	in	IN	IN	_	31	case	_	_
31	zeta-chain	zeta-chain	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	defects	defect	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	paralleled	parallel	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	impaired	impaired	JJ	JJ	_	8	amod	_	_
8	ability	ability	NN	NN	_	4	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	produce	produce	VB	VB	_	8	acl	_	_
11	Th1	th1	NN	NN	_	12	compound	_	_
12	cytokines	cytokine	NNS	NNS	_	10	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IL-2	il-2	NN	NN	_	12	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IFN-gamma	ifn-gamma	NN	NN	_	14	conj	_	_
17	)	)	-RRB-	-RRB-	_	14	punct	_	_
18	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	initial	initial	JJ	JJ	_	3	amod	_	_
3	changes	change	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	followed	follow	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	eventual	eventual	JJ	JJ	_	9	amod	_	_
9	loss	loss	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	TCR	tcr	NN	NN	_	13	compound	_	_
12	zeta	zeta	NN	NN	_	13	compound	_	_
13	chain	chain	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	p56	p56	NN	NN	_	17	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	lck	lck	NN	NN	_	13	conj	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	a	a	DT	DT	_	22	det	_	_
21	marked	marked	JJ	JJ	_	22	amod	_	_
22	decrease	decrease	NN	NN	_	9	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	cytotoxic	cytotoxic	JJ	JJ	_	25	amod	_	_
25	function	function	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	increased	increase	VBN	VBN	_	3	amod	_	_
3	rate	rate	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	lysosomal	lysosomal	JJ	JJ	_	6	amod	_	_
6	degradation	degradation	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	one	one	CD	CD	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	mechanisms	mechanism	NNS	NNS	_	8	nmod	_	_
12	responsible	responsible	JJ	JJ	_	11	amod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	loss	loss	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	zeta-chain	zeta-chain	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	interleukin-10	interleukin-10	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	on	on	IN	IN	_	11	case	_	_
7	B-cell	b-cell	NN	NN	_	11	compound	_	_
8	chronic	chronic	JJ	JJ	_	11	amod	_	_
9	lymphocytic	lymphocytic	JJ	JJ	_	11	amod	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	B-cell	b-cell	NN	NN	_	8	compound	_	_
2	chronic	chronic	JJ	JJ	_	8	amod	_	_
3	lymphocytic	lymphocytic	JJ	JJ	_	8	amod	_	_
4	leukemia	leukemia	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	B-CLL	b-cll	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	accumulate	accumulate	VBP	VBP	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	G0/G1	g0/g1	NN	NN	_	15	compound	_	_
15	phase	phase	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	cycle	cycle	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
22	that	that	IN	IN	_	27	mark	_	_
23	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
24	malignant	malignant	JJ	JJ	_	25	amod	_	_
25	expansion	expansion	NN	NN	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	due	due	JJ	JJ	_	21	ccomp	_	_
28	,	,	,	,	_	27	punct	_	_
29	at	at	IN	IN	_	32	advmod	_	_
30	least	least	JJS	JJS	_	29	mwe	_	_
31	in	in	IN	IN	_	32	case	_	_
32	part	part	NN	NN	_	27	nmod	_	_
33	,	,	,	,	_	27	punct	_	_
34	to	to	TO	TO	_	36	case	_	_
35	a	a	DT	DT	_	36	det	_	_
36	delay	delay	NN	NN	_	27	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	death	death	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	cellular	cellular	JJ	JJ	_	17	nsubj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	factors	factor	NNS	NNS	_	4	conj	_	_
8	responsible	responsible	JJ	JJ	_	4	amod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	delay	delay	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	B-CLL	b-cll	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	death	death	NN	NN	_	11	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	unknown	unknown	JJ	JJ	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	B-CLL	b-cll	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	do	do	VBP	VBP	_	4	aux	_	_
4	express	express	VB	VB	_	0	root	_	_
5	receptors	receptor	NNS	NNS	_	4	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	interferon-alpha	interferon-alpha	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IFN-alpha	ifn-alpha	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	IFN-gamma	ifn-gamma	NN	NN	_	7	conj	_	_
13	,	,	,	,	_	4	punct	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	activation	activation	NN	NN	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	both	both	DT	DT	_	15	nmod	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	shown	show	VBN	VBN	_	4	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	promote	promote	VB	VB	_	20	xcomp	_	_
23	B-CLL	b-cll	NN	NN	_	24	compound	_	_
24	survival	survival	NN	NN	_	22	dobj	_	_
25	in	in	FW	FW	_	24	amod	_	_
26	vitro	vitro	FW	FW	_	25	dep	_	_
27	by	by	IN	IN	_	28	mark	_	_
28	preventing	prevent	VBG	VBG	_	22	advcl	_	_
29	apoptosis	apoptosis	NN	NN	_	28	dobj	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	interleukin-10	interleukin-10	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	IL-10	il-10	NN	NN	_	6	compound	_	_
5	)	)	-RRB-	-RRB-	_	6	punct	_	_
6	receptor	receptor	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	another	another	DT	DT	_	9	det	_	_
9	member	member	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	IFN	ifn	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	but	but	CC	CC	_	9	cc	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	ligand	ligand	NN	NN	_	24	nsubjpass	_	_
19	,	,	,	,	_	18	punct	_	_
20	IL-10	il-10	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	18	punct	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	reported	report	VBN	VBN	_	9	conj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	induce	induce	VB	VB	_	24	xcomp	_	_
27	apoptosis	apoptosis	NN	NN	_	26	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	B-CLL	b-cll	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	undertook	undertake	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	biochemical	biochemical	JJ	JJ	_	10	amod	_	_
10	analysis	analysis	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	IL-10	il-10	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	on	on	IN	IN	_	19	case	_	_
16	freshly	freshly	RB	RB	_	17	advmod	_	_
17	isolated	isolate	VBN	VBN	_	19	amod	_	_
18	B-CLL	b-cll	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	characterized	characterize	VBD	VBD	_	7	conj	_	_
22	the	the	DT	DT	_	24	det	_	_
23	functional	functional	JJ	JJ	_	24	amod	_	_
24	responsiveness	responsiveness	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	IL-10	il-10	NN	NN	_	27	compound	_	_
27	binding	binding	NN	NN	_	24	nmod	_	_
28	to	to	TO	TO	_	32	case	_	_
29	its	its	PRP$	PRP$	_	32	nmod:poss	_	_
30	constitutively	constitutively	RB	RB	_	32	advmod	_	_
31	expressed	express	VBN	VBN	_	32	amod	_	_
32	receptor	receptor	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	B-CLL	b-cll	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	bind	bind	VBP	VBP	_	2	ccomp	_	_
7	IL-10	il-10	NN	NN	_	6	dobj	_	_
8	with	with	IN	IN	_	10	case	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	specificity	specificity	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	express	express	VBP	VBP	_	6	conj	_	_
13	between	between	IN	IN	_	19	case	_	_
14	47	47	CD	CD	_	19	nummod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	127	127	CD	CD	_	14	conj	_	_
17	IL-10	il-10	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	12	nmod	_	_
20	per	per	IN	IN	_	21	case	_	_
21	cell	cell	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	with	with	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	dissociation	dissociation	NN	NN	_	26	compound	_	_
26	constant	constant	NN	NN	_	12	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	range	range	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	36	case	_	_
31	168	168	CD	CD	_	33	nummod	_	_
32	to	to	TO	TO	_	33	dep	_	_
33	426	426	CD	CD	_	36	nummod	_	_
34	x	x	CC	CC	_	33	cc	_	_
35	10(-12)	10(-12)	CD	CD	_	33	conj	_	_
36	mol/L	mol/l	NN	NN	_	29	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	Ligand	ligand	NN	NN	_	13	nsubj	_	_
2	binding	binding	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	activation	activation	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL-10	il-10	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	1	nmod	_	_
9	expressed	express	VBN	VBN	_	8	acl	_	_
10	on	on	IN	IN	_	12	case	_	_
11	B-CLL	b-cll	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	results	result	VBZ	VBZ	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	signal	signal	NN	NN	_	19	compound	_	_
19	transducer	transducer	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	activator	activator	NN	NN	_	23	compound	_	_
22	of	of	IN	IN	_	23	amod	_	_
23	transcription	transcription	NN	NN	_	19	conj	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	STAT1	stat1	NN	NN	_	19	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	19	cc	_	_
29	STAT3	stat3	NN	NN	_	19	conj	_	_
30	proteins	protein	NNS	NNS	_	19	dep	_	_
31	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	STAT	stat	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	identical	identical	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	IL-10	il-10	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	8	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	normal	normal	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	similar	similar	JJ	JJ	_	8	conj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	IFN-alpha	ifn-alpha	NN	NN	_	17	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	STAT1	stat1	NN	NN	_	19	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	STAT3	stat3	NN	NN	_	21	conj	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	IFN-gamma	ifn-gamma	NN	NN	_	19	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	STAT1	stat1	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	receptor	receptor	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	19	dep	_	_
32	in	in	IN	IN	_	33	case	_	_
33	CLL	cll	NN	NN	_	19	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Further	further	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	consecutive	consecutive	JJ	JJ	_	5	amod	_	_
5	samples	sample	NNS	NNS	_	20	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	fresh	fresh	JJ	JJ	_	8	amod	_	_
8	blood	blood	NN	NN	_	5	nmod	_	_
9	obtained	obtain	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	9	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	B-CLL	b-cll	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	20	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	addition	addition	NN	NN	_	20	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IL-10	il-10	NN	NN	_	17	nmod	_	_
20	inhibited	inhibit	VBD	VBD	_	0	root	_	_
21	B-CLL	b-cll	NN	NN	_	22	compound	_	_
22	proliferation	proliferation	NN	NN	_	20	dobj	_	_
23	,	,	,	,	_	20	punct	_	_
24	enhanced	enhance	VBD	VBD	_	20	conj	_	_
25	B-CLL	b-cll	NN	NN	_	26	compound	_	_
26	differentiation	differentiation	NN	NN	_	24	dobj	_	_
27	,	,	,	,	_	20	punct	_	_
28	but	but	CC	CC	_	20	cc	_	_
29	did	do	VBD	VBD	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	induce	induce	VB	VB	_	20	conj	_	_
32	apoptosis	apoptosis	NN	NN	_	31	dobj	_	_
33	.	.	.	.	_	20	punct	_	_

1	Indeed	indeed	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	IL-10	il-10	NN	NN	_	9	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	like	like	IN	IN	_	6	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	9	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	able	able	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	reduce	reduce	VB	VB	_	9	xcomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	amount	amount	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	B-CLL	b-cll	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	death	death	NN	NN	_	14	nmod	_	_
19	caused	cause	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	hydrocortisone-induced	hydrocortisone-induced	JJ	JJ	_	22	amod	_	_
22	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	cytokines	cytokine	NNS	NNS	_	15	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	signal	signal	VBP	VBP	_	4	acl:relcl	_	_
8	through	through	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	interferon	interferon	NN	NN	_	11	compound	_	_
11	family	family	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	receptors	receptor	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	have	have	VBP	VBP	_	2	ccomp	_	_
16	comparable	comparable	JJ	JJ	_	17	amod	_	_
17	functional	functional	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	15	dobj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	B-CLL	b-cll	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	isotype-specific	isotype-specific	JJ	JJ	_	3	amod	_	_
3	activator	activator	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	13	case	_	_
5	major	major	JJ	JJ	_	13	amod	_	_
6	histocompatibility	histocompatibility	NN	NN	_	13	compound	_	_
7	complex	complex	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	MHC	mhc	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	genes	gene	NNS	NNS	_	3	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	independent	independent	JJ	JJ	_	3	acl:relcl	_	_
17	of	of	IN	IN	_	20	case	_	_
18	class	class	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	transactivator	transactivator	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Patients	patient	NNS	NNS	_	13	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	one	one	CD	CD	_	4	nummod	_	_
4	type	type	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	12	case	_	_
6	major	major	JJ	JJ	_	9	amod	_	_
7	histocompatibility	histocompatibility	NN	NN	_	9	compound	_	_
8	complex	complex	NN	NN	_	9	compound	_	_
9	class	class	NN	NN	_	12	compound	_	_
10	II	ii	CD	CD	_	9	nummod	_	_
11	combined	combined	JJ	JJ	_	12	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	4	nmod	_	_
13	have	have	VBP	VBP	_	0	root	_	_
14	mutations	mutation	NNS	NNS	_	13	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	termed	term	VBN	VBN	_	17	acl	_	_
19	class	class	NN	NN	_	21	compound	_	_
20	II	ii	CD	CD	_	21	nummod	_	_
21	transactivator	transactivator	NN	NN	_	18	xcomp	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CIITA	ciita	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	21	punct	_	_
26	which	which	WDT	WDT	_	28	nsubj	_	_
27	coordinately	coordinately	RB	RB	_	28	advmod	_	_
28	controls	control	VBZ	VBZ	_	21	acl:relcl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	transcription	transcription	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	38	case	_	_
32	the	the	DT	DT	_	38	det	_	_
33	three	three	CD	CD	_	38	nummod	_	_
34	major	major	JJ	JJ	_	38	amod	_	_
35	human	human	JJ	JJ	_	38	amod	_	_
36	class	class	NN	NN	_	38	compound	_	_
37	II	ii	CD	CD	_	38	nummod	_	_
38	genes	gene	NNS	NNS	_	30	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	HLA-DR	hla-dr	NN	NN	_	38	appos	_	_
41	,	,	,	,	_	40	punct	_	_
42	-DQ	-dq	NN	NN	_	40	conj	_	_
43	,	,	,	,	_	40	punct	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	-DP	-dp	NN	NN	_	40	conj	_	_
46	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	8	det	_	_
4	experimentally	experimentally	RB	RB	_	5	advmod	_	_
5	derived	derive	VBN	VBN	_	8	amod	_	_
6	B-lymphoblastoid	b-lymphoblastoid	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	13	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	clone	clone	NN	NN	_	8	appos	_	_
11	13	13	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	8	punct	_	_
13	expresses	express	VBZ	VBZ	_	0	root	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HLADQ	hladq	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	absence	absence	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	HLA-DR	hla-dr	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	HLA-DP	hla-dp	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	13	punct	_	_
26	despite	despite	IN	IN	_	28	case	_	_
27	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
28	mapping	mapping	NN	NN	_	13	nmod	_	_
29	by	by	IN	IN	_	31	case	_	_
30	complementation	complementation	NN	NN	_	31	compound	_	_
31	analysis	analysis	NN	NN	_	28	nmod	_	_
32	to	to	TO	TO	_	34	case	_	_
33	this	this	DT	DT	_	34	det	_	_
34	group	group	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	possible	possible	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	one	one	CD	CD	_	12	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	clone	clone	NN	NN	_	11	compound	_	_
9	13	13	CD	CD	_	11	nummod	_	_
10	CIITA	ciita	NN	NN	_	11	compound	_	_
11	alleles	allele	NNS	NNS	_	5	nmod	_	_
12	bore	bear	VBP	VBP	_	3	ccomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	mutation	mutation	NN	NN	_	12	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	allowed	allow	VBD	VBD	_	14	acl:relcl	_	_
17	HLA-DQ	hla-dq	NN	NN	_	16	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	but	but	CC	CC	_	17	cc	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	HLA-DR	hla-dr	NN	NN	_	17	conj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	-DP	-dp	NN	NN	_	21	conj	_	_
24	transcription	transcription	NN	NN	_	21	dep	_	_
25	.	.	.	.	_	3	punct	_	_

1	Alternatively	alternatively	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	another	another	DT	DT	_	4	det	_	_
4	factor	factor	NN	NN	_	11	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	distinct	distinct	JJ	JJ	_	4	amod	_	_
7	from	from	IN	IN	_	8	case	_	_
8	CIITA	ciita	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	might	might	MD	MD	_	11	aux	_	_
11	control	control	VB	VB	_	0	root	_	_
12	HLA-DQ	hla-dq	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	ectopic	ectopic	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	CIITA	ciita	NN	NN	_	9	compound	_	_
9	cDNAs	cdna	NNS	NNS	_	6	nmod	_	_
10	derived	derive	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	16	case	_	_
12	reverse	reverse	JJ	JJ	_	16	amod	_	_
13	transcriptase	transcriptase	NN	NN	_	16	compound	_	_
14	polymerase	polymerase	NN	NN	_	16	compound	_	_
15	chain	chain	NN	NN	_	16	compound	_	_
16	reaction	reaction	NN	NN	_	10	nmod	_	_
17	from	from	IN	IN	_	18	case	_	_
18	clone	clone	NN	NN	_	16	nmod	_	_
19	13	13	CD	CD	_	18	nummod	_	_
20	do	do	VBP	VBP	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	restore	restore	VB	VB	_	2	ccomp	_	_
23	expression	expression	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	HLA-DQ	hla-dq	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	30	case	_	_
27	another	another	DT	DT	_	30	det	_	_
28	CIITA-deficient	ciita-deficient	JJ	JJ	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	line	line	NN	NN	_	22	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	RJ2.2.5	rj2.2.5	NN	NN	_	30	appos	_	_
33	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	no	no	DT	DT	_	6	neg	_	_
5	CIITA	ciita	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	detectable	detectable	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	clone	clone	NN	NN	_	13	compound	_	_
11	13	13	CD	CD	_	10	nummod	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	somatic	somatic	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	fusion	fusion	NN	NN	_	12	nsubj	_	_
7	between	between	IN	IN	_	8	case	_	_
8	clone	clone	NN	NN	_	6	nmod	_	_
9	13	13	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	RJ2.2.5	rj2.2.5	NN	NN	_	8	conj	_	_
12	restored	restore	VBD	VBD	_	0	root	_	_
13	expression	expression	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HLA-DQ	hla-dq	NN	NN	_	17	compound	_	_
17	haplotype	haplotype	NN	NN	_	13	nmod	_	_
18	encoded	encode	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	RJ2.2.5	rj2.2.5	NN	NN	_	23	compound	_	_
22	DQB	dqb	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
7	the	the	DT	DT	_	8	det	_	_
8	existence	existence	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	HLA-DQ	hla-dq	NN	NN	_	14	compound	_	_
12	isotype-specific	isotype-specific	JJ	JJ	_	14	amod	_	_
13	trans-acting	trans-acting	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	functions	function	VBZ	VBZ	_	14	acl:relcl	_	_
18	independently	independently	RB	RB	_	17	advmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	CIITA	ciita	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Uncoupling	uncoupling	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	cycle	cycle	NN	NN	_	5	compound	_	_
5	arrest	arrest	NN	NN	_	1	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
11	differentiation	differentiation	NN	NN	_	12	compound	_	_
12	markers	marker	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	HL60	hl60	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	variants	variant	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Differentiation	differentiation	NN	NN	_	3	nsubj	_	_
2	generally	generally	RB	RB	_	3	advmod	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	cycle	cycle	NN	NN	_	7	compound	_	_
7	arrest	arrest	NN	NN	_	3	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	leukemia	leukemia	NN	NN	_	4	compound	_	_
3	HL60	hl60	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	respond	respond	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	11	compound	_	_
11	D3	d3	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	1,25D3	1,25d3	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	expressing	express	VBG	VBG	_	5	advcl	_	_
17	a	a	DT	DT	_	18	det	_	_
18	number	number	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	markers	marker	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	monocyte/macrophage	monocyte/macrophage	NN	NN	_	24	compound	_	_
24	phenotype	phenotype	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	5	cc	_	_
26	become	become	VBP	VBP	_	5	conj	_	_
27	arrested	arrest	VBN	VBN	_	26	xcomp	_	_
28	predominantly	predominantly	RB	RB	_	32	advmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	G1	g1	NN	NN	_	32	compound	_	_
32	phase	phase	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	cycle	cycle	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	series	series	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	A	a	NN	NN	_	4	dobj	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	12	case	_	_
11	1,25D3-resistant	1,25d3-resistant	JJ	JJ	_	12	amod	_	_
12	variants	variant	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HL60	hl60	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	proliferate	proliferate	VBP	VBP	_	12	acl:relcl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	presence	presence	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	1,25D3	1,25d3	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	do	do	VBP	VBP	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	express	express	VB	VB	_	17	conj	_	_
27	differentiation	differentiation	NN	NN	_	28	compound	_	_
28	markers	marker	NNS	NNS	_	26	dobj	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	Exp.	Exp.	NNP	NNP	_	32	compound	_	_
31	Cell	Cell	NNP	NNP	_	32	compound	_	_
32	Res.	Res.	NNP	NNP	_	4	dep	_	_
33	224	224	CD	CD	_	35	nummod	_	_
34	,	,	,	,	_	35	punct	_	_
35	312	312	CD	CD	_	32	dep	_	_
36	,	,	,	,	_	32	punct	_	_
37	1996	1996	CD	CD	_	32	amod	_	_
38	)	)	-RRB-	-RRB-	_	32	punct	_	_
39	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	another	another	DT	DT	_	7	det	_	_
5	series	series	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	B	b	NN	NN	_	3	dobj	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	11	case	_	_
10	such	such	JJ	JJ	_	11	amod	_	_
11	variants	variant	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	differ	differ	VBP	VBP	_	7	acl:relcl	_	_
15	from	from	IN	IN	_	18	case	_	_
16	A	a	NN	NN	_	18	compound	_	_
17	series	series	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	grown	grow	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	similar	similar	JJ	JJ	_	22	amod	_	_
22	concentrations	concentration	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	1,25D3	1,25d3	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	28	mark	_	_
26	that	that	IN	IN	_	28	mark	_	_
27	they	they	PRP	PRP	_	28	nsubj	_	_
28	express	express	VBP	VBP	_	14	advcl	_	_
29	the	the	DT	DT	_	31	det	_	_
30	CD14	cd14	NN	NN	_	31	compound	_	_
31	antigen	antigen	NN	NN	_	28	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	nonspecific	nonspecific	JJ	JJ	_	34	amod	_	_
34	esterase	esterase	NN	NN	_	31	conj	_	_
35	,	,	,	,	_	28	punct	_	_
36	characteristic	characteristic	JJ	JJ	_	28	advmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	monocyte	monocyte	NN	NN	_	36	nmod	_	_
40	,	,	,	,	_	28	punct	_	_
41	while	while	IN	IN	_	42	mark	_	_
42	continuing	continue	VBG	VBG	_	28	advcl	_	_
43	to	to	TO	TO	_	42	xcomp	_	_
44	proliferate	proliferate	NN	NN	_	43	dobj	_	_
45	and	and	CC	CC	_	28	cc	_	_
46	they	they	PRP	PRP	_	47	nsubj	_	_
47	develop	develop	VBP	VBP	_	28	conj	_	_
48	hypotetraploid	hypotetraploid	JJ	JJ	_	49	amod	_	_
49	DNA	dna	NN	NN	_	53	compound	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	4C	4c	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	content	content	NN	NN	_	47	dobj	_	_
54	at	at	IN	IN	_	56	case	_	_
55	higher	higher	JJR	JJR	_	56	amod	_	_
56	concentrations	concentration	NNS	NNS	_	47	nmod	_	_
57	of	of	IN	IN	_	59	case	_	_
58	ambient	ambient	JJ	JJ	_	59	amod	_	_
59	1,25D3	1,25d3	NN	NN	_	56	nmod	_	_
60	than	than	IN	IN	_	64	case	_	_
61	the	the	DT	DT	_	64	det	_	_
62	A	a	NN	NN	_	64	compound	_	_
63	series	series	NN	NN	_	64	compound	_	_
64	cells	cell	NNS	NNS	_	56	nmod	_	_
65	.	.	.	.	_	3	punct	_	_

1	Cells	cell	NNS	NNS	_	16	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	series	series	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	4C	4c	NN	NN	_	9	compound	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	content	content	NN	NN	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	100B	100b	NN	NN	_	9	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	200B	200b	NN	NN	_	11	conj	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	differed	differ	VBD	VBD	_	0	root	_	_
17	from	from	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	A	a	NN	NN	_	22	compound	_	_
20	series	series	NN	NN	_	22	compound	_	_
21	4C	4c	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	absence	absence	NN	NN	_	16	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	DNA	dna	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	25	nmod	_	_
29	by	by	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	full-length	full-length	JJ	JJ	_	32	amod	_	_
32	Sp1	sp1	NN	NN	_	28	nmod	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factor	factor	NN	NN	_	32	dep	_	_
35	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	series	series	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	resembled	resemble	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	A	a	NN	NN	_	10	compound	_	_
9	series	series	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	xcomp	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	exhibiting	exhibit	VBG	VBG	_	6	advcl	_	_
13	faster	faster	JJR	JJR	_	15	amod	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	rates	rate	NNS	NNS	_	12	dobj	_	_
16	than	than	IN	IN	_	20	mark	_	_
17	the	the	DT	DT	_	20	det	_	_
18	parental	parental	JJ	JJ	_	20	amod	_	_
19	HL60	hl60	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	dep	_	_
21	and	and	CC	CC	_	6	cc	_	_
22	showed	show	VBD	VBD	_	6	conj	_	_
23	high	high	JJ	JJ	_	24	amod	_	_
24	levels	level	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	vitamin	vitamin	NN	NN	_	28	compound	_	_
27	D	d	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	retinoid	retinoid	NN	NN	_	33	compound	_	_
31	receptor	receptor	NN	NN	_	33	compound	_	_
32	X	x	NN	NN	_	33	compound	_	_
33	proteins	protein	NNS	NNS	_	28	conj	_	_
34	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	initial	initial	JJ	JJ	_	7	amod	_	_
7	steps	step	NNS	NNS	_	14	nsubj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	1,25D3	1,25d3	NN	NN	_	12	compound	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	7	nmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	intact	intact	JJ	JJ	_	3	ccomp	_	_
15	in	in	IN	IN	_	19	case	_	_
16	B	b	NN	NN	_	19	compound	_	_
17	series	series	NNS	NNS	_	19	compound	_	_
18	resistant	resistant	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	lead	lead	VBP	VBP	_	14	conj	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	appearance	appearance	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	early	early	JJ	JJ	_	27	amod	_	_
27	markers	marker	NNS	NNS	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	monocytic	monocytic	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	progression	progression	NN	NN	_	17	nsubjpass	_	_
5	to	to	TO	TO	_	7	case	_	_
6	subsequent	subsequent	JJ	JJ	_	7	amod	_	_
7	events	event	NNS	NNS	_	4	nmod	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	comprise	comprise	VBP	VBP	_	7	acl:relcl	_	_
10	terminal	terminal	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	cycle	cycle	NN	NN	_	15	compound	_	_
15	arrest	arrest	NN	NN	_	11	conj	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	halted	halt	VBN	VBN	_	0	root	_	_
18	during	during	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	adaptation	adaptation	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	presence	presence	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	1,25D3	1,25d3	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	17	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	availability	availability	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	variant	variant	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	should	should	MD	MD	_	10	aux	_	_
10	provide	provide	VB	VB	_	0	root	_	_
11	a	a	DT	DT	_	12	det	_	_
12	system	system	NN	NN	_	10	dobj	_	_
13	for	for	IN	IN	_	14	mark	_	_
14	studying	study	VBG	VBG	_	12	acl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	link	link	NN	NN	_	14	dobj	_	_
17	between	between	IN	IN	_	18	case	_	_
18	differentiation	differentiation	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	cycle	cycle	NN	NN	_	22	compound	_	_
22	arrest	arrest	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	10	punct	_	_

