{"id":1240470273511612400,"conversation_id":"1240470262967152640","created_at":1584586134000,"date":"2020-03-19","time":"02:48:54","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"11/ Interpretation: this is an important study! It is the first complete RCT that I am aware of for treatments for COVID-19. It is remarkable that the authors were able to put this together in the midst of such a crisis and it does provide us with important/useful data","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":1,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470273511612416","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470272639148000,"conversation_id":"1240470262967152640","created_at":1584586134000,"date":"2020-03-19","time":"02:48:54","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"10/ Tolerability: 14% discontinued LPV/r because of adverse GI effects, but overall was well tolerated without serious adverse events.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470272639148032","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470271724867600,"conversation_id":"1240470262967152640","created_at":1584586134000,"date":"2020-03-19","time":"02:48:54","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"9/ Findings: in subgroup analysis, among those for whom LPV/r was started within 12 days of symptom onset, it *was* associated with faster clinical improvement (but not when started later). Patients in LPV/r arm had *shorter* ICU stays.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470271724867585","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470270764372000,"conversation_id":"1240470262967152640","created_at":1584586134000,"date":"2020-03-19","time":"02:48:54","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"8/ Findings: trial did NOT meet primary outcomes. However, 3 patients in the LPV/r arm died within 24 hours of enrolling and with a *modified intention to treat* analysis (excluding those 3 individuals), the median time to clinical improvement was different at 15 days vs 16 days","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":1,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470270764371968","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470268461621200,"conversation_id":"1240470262967152640","created_at":1584586133000,"date":"2020-03-19","time":"02:48:53","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"6/ Study designed to \"provide the trial with 80% power to detect a difference ... of 8 days in the median time to clinical improvement between the two groups\" assuming median duration of hospitalization was 20 days. (Note: seems like a large difference to expect from this agent)","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470268461621249","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470267484409900,"conversation_id":"1240470262967152640","created_at":1584586133000,"date":"2020-03-19","time":"02:48:53","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"5/ Intervention: LPV/r (400 mg / 100 mg BID x 14 days) plus standard of care or standard of care alone. “Standard of care:” included any necessary interventions including supplemental oxygen, noninvasive and invasive ventilation, antibiotics, vasopressors, RRT, and ECMO","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470267484409856","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470266548977700,"conversation_id":"1240470262967152640","created_at":1584586133000,"date":"2020-03-19","time":"02:48:53","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"4/ Exclusion criteria:\n1. Pregnancy\n2. Known allergy to LPV/r\n3. Severe liver disease (cirrhosis or ALT/AST > 5x ULN)\n4. Necessary meds that are contraindicated with LPV/r","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470266548977670","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470265555009500,"conversation_id":"1240470262967152640","created_at":1584586132000,"date":"2020-03-19","time":"02:48:52","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"3/ Inclusion criteria:\n1. + RT-PCR for SARS-CoV-2\n2. Age > 18\n3. Pneumonia confirmed by chest imaging\n4. SpO2 94% or less on ambient air or PaO2:FiO2 < 300 mmHg","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470265555009542","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1240470264619696000,"conversation_id":"1240470262967152640","created_at":1584586132000,"date":"2020-03-19","time":"02:48:52","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"2/ Baseline population: 201 patients at a hospital in Wuhan, China, baseline SpO2 ≤ 94% on ambient air or P/F < 300 mmHg. Randomization stratified to balance supplemental O2 (RA - 2L, NIV, MV/ECMO) and then 1:1 LPV/r versus standard of care. Table 1 shows balanced groups","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1240470264619696133","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1239520401321058300,"conversation_id":"1239520397537705985","created_at":1584359667000,"date":"2020-03-16","time":"11:54:27","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"To my knowledge there is no clinical data yet for hydroxychloroquine although it is more available in much of the world (including the US) and is being used/studied for COVID-19 disease.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":1,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1239520401321058305","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1239520397537706000,"conversation_id":"1239520397537705985","created_at":1584359666000,"date":"2020-03-16","time":"11:54:26","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"Report of interim data out of China: more than 100 patients treated w/chloroquine: superior to “the control treatment in inhibiting the exacerbation of pneumonia, improving lung imaging findings, promoting a virus-negative conversion, and shortening the length of disease course.”","mentions":[],"urls":[],"photos":[],"replies_count":2,"retweets_count":9,"likes_count":18,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1239520397537705985","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1238278856928301000,"conversation_id":"1238278856928301056","created_at":1584063660000,"date":"2020-03-13","time":"01:41:00","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"Wonder if all nursing homes should switch from nebulized medications to delivery by metered dose inhaler to prevent possible aerosolization of SARS-CoV-2 in undiagnosed patients given inadequate testing and rampant community spread all over the country. #FlattenTheCurve","mentions":[],"urls":[],"photos":[],"replies_count":0,"retweets_count":2,"likes_count":6,"hashtags":["#flattenthecurve"],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1238278856928301056","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237153067960844300,"conversation_id":"1237153064412422144","created_at":1583795251000,"date":"2020-03-09","time":"23:07:31","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"4/ They also note alarmingly that a single point mutation \"N501T\" may markedly enhance binding of SARS-CoV-2 RBD to human ACE2. If this happens the implication is the virus could become even more transmissible between people.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237153067960844290","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237153065960198100,"conversation_id":"1237153064412422144","created_at":1583795250000,"date":"2020-03-09","time":"23:07:30","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"2/ ACE2 \"is highly expressed in the heart and lungs.\" Acute myocarditis has been seen and is a cause of significant morbidity and mortality in cohorts out of China. Follow up data from SARS cohorts from 2002/2003 suggest there may be long term cardiovascular damage.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237153065960198146","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237127929227862000,"conversation_id":"1237127923469111296","created_at":1583789257000,"date":"2020-03-09","time":"21:27:37","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"5/ Would be interesting to see observational data about how patients on chloroquine or hydroxychloroquine (ie those with lupus or rheumatoid arthritis) do after SARS-CoV-2 infection. Is anyone aware of studies?","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":6,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237127929227862021","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237127928200286200,"conversation_id":"1237127923469111296","created_at":1583789257000,"date":"2020-03-09","time":"21:27:37","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"4/ \"Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration.\"","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":2,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237127928200286208","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237127925771702300,"conversation_id":"1237127923469111296","created_at":1583789256000,"date":"2020-03-09","time":"21:27:36","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"3/ \"Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.... [We] demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection...\"","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":1,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237127925771702272","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237127924521799700,"conversation_id":"1237127923469111296","created_at":1583789256000,"date":"2020-03-09","time":"21:27:36","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"2/ \"Remdesivir is an adenosine analogue, which incorporates into nascent viral RNA chains and results in pre-mature termination.\" It was developed for Ebola and has in vitro efficacy against SARS-CoV-2","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237127924521799687","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237123667135467500,"conversation_id":"1237123662177800192","created_at":1583788241000,"date":"2020-03-09","time":"21:10:41","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"6/ Also wonder about a \"SARS-PrEP\" trial: putting people in at risk communities on LOP/rtv prior before they are infected and seeing if differences between groups","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237123667135467520","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237123666380546000,"conversation_id":"1237123662177800192","created_at":1583788241000,"date":"2020-03-09","time":"21:10:41","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"5/ Perhaps there are other immunologic changes from HIV that lead to protection from SARS. Would be helpful to see series including PLWH.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237123666380546048","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237123665642377200,"conversation_id":"1237123662177800192","created_at":1583788241000,"date":"2020-03-09","time":"21:10:41","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"4/ Many questions: will these findings hold up in larger randomized trials? is the 3CLpro protease of SARSCoV2 similar enough to the original SARS virus that LOP/rtv will have activity? if there is activity how early does LOP/rtv have to be started to have efficacy?","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237123665642377218","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237123663301873700,"conversation_id":"1237123662177800192","created_at":1583788240000,"date":"2020-03-09","time":"21:10:40","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"2/ 3CLpro is a viral protease \"that cleaves the large replicase polyproteins during viral replication.\" Lopinavir–ritonavir inhibits 3CLpro and has shown some activity in vitro and in non-randomized trials for SARS.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237123663301873665","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237089956180512800,"conversation_id":"1237088138624991233","created_at":1583780204000,"date":"2020-03-09","time":"18:56:44","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"Also I feel like there has been a lot of speculation on the role of smoking in the pathogenesis of COVID-19 -- in this cohort only 6% smoked and no significant difference between those who died and those who survived (9% vs 4%, p = 0.21).","mentions":[],"urls":[],"photos":[],"replies_count":0,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237089956180512769","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1237044933426544600,"conversation_id":"1237044930469601281","created_at":1583769469000,"date":"2020-03-09","time":"15:57:49","timezone":"UTC","user_id":965643717502627800,"username":"ericmeyerowitz","name":"Eric Meyerowitz, MD","place":"","tweet":"4/ Perhaps we should instruct all PUI (regardless of whether they test positive) to self-isolate for the 14 days until we know more about the performance characteristics of our testing","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricMeyerowitz/status/1237044933426544640","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"965643717502627840","username":"EricMeyerowitz"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1274752358124142600,"conversation_id":"1274751514850942979","created_at":1592759620000,"date":"2020-06-21","time":"17:13:40","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Oops. I meant 6 countries (not 5); Pakistan was added in recent days","mentions":[],"urls":[],"photos":[],"replies_count":2,"retweets_count":5,"likes_count":38,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1274752358124142594","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1274504955810820000,"conversation_id":"1274504955810820096","created_at":1592700635000,"date":"2020-06-21","time":"00:50:35","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"“Slow the testing down”\nOMFG","mentions":[],"urls":[],"photos":[],"replies_count":124,"retweets_count":524,"likes_count":3317,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1274504955810820096","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1274383081290428400,"conversation_id":"1274383078215974912","created_at":1592671578000,"date":"2020-06-20","time":"16:46:18","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"News from very successful countries: containment is an enduring challenge. Places w/ no or very few cases for weeks:\nAustralia 25 new cases \nSouth Korea 67 new cases, most in 3 wks\nNew Zealand 2 new cases, asymptomatic, couple returning from India\nBeijing >200 cases;0 for 55 days","mentions":[],"urls":[],"photos":[],"replies_count":6,"retweets_count":26,"likes_count":68,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1274383081290428417","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1273006648785686500,"conversation_id":"1273003396975325184","created_at":1592343411000,"date":"2020-06-16","time":"21:36:51","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"BTW, NO place is good for a 20,000 person rally. \nAnd you can put X is the number when X >2","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":11,"likes_count":65,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1273006648785686530","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1272220871831109600,"conversation_id":"1272220854378622977","created_at":1592156067000,"date":"2020-06-14","time":"17:34:27","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"9. The magnitude of transmissibility from people without symptoms remains unknown and is hopefully low, but all the more reason to 😷😷😷 #masksforall and other mitigation measures. One last below the surface group are the chronic #COVID19 hits","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":58,"likes_count":160,"hashtags":["#masksforall","#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1272220871831109632","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1271477103297392600,"conversation_id":"1271476774757523457","created_at":1591978738000,"date":"2020-06-12","time":"16:18:58","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"BTW this is the 1st wave, WSJ. \nWe have a ways to go to just get through this one.","mentions":[],"urls":[],"photos":[],"replies_count":12,"retweets_count":25,"likes_count":156,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1271477103297392641","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1271067908949467100,"conversation_id":"1271064596728561667","created_at":1591881179000,"date":"2020-06-11","time":"13:12:59","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The patient was previously healthy, no pre-existing medical conditions. Yet, as the infection took its toll on the woman’s lungs they were  “completely plastered to tissue around them, the heart, the chest wall and diaphragm\"\nFirst US case, previously a 2-lung transplant in Italy","mentions":[],"urls":[],"photos":[],"replies_count":29,"retweets_count":289,"likes_count":829,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1271067908949467136","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1270858539951505400,"conversation_id":"1270550026574430208","created_at":1591831261000,"date":"2020-06-10","time":"23:21:01","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Texas is also of concern with positive test this week at 9.1% and spike in hospitalizations","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":53,"likes_count":150,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1270858539951505408","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1270178619168415700,"conversation_id":"1270178612457598976","created_at":1591669156000,"date":"2020-06-09","time":"02:19:16","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"To provide meaningful data on the magnitude of transmissibility from asymptomatic people a prospective study would need to be done to quantify spread & ideally include:\n—contact tracing, forward and backward\n—culture of the virus\n—virus genomic sequence to precisely define route","mentions":[],"urls":[],"photos":[],"replies_count":7,"retweets_count":85,"likes_count":351,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1270178619168415745","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1270178618421858300,"conversation_id":"1270178612457598976","created_at":1591669156000,"date":"2020-06-09","time":"02:19:16","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"But the whether the people in  this asymptomatic category (Asx) spread like those who have symptoms (or pre-symptomatics) is not determined. We only know the viral loads are similar from multiple reports. And we do know some spread occurs from ASx people.","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":103,"likes_count":356,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1270178618421858304","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1269359676128280600,"conversation_id":"1269359663591510016","created_at":1591473905000,"date":"2020-06-06","time":"20:05:05","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"In order to get our arms around this critical issue, we need to find asymptomatic people to avoid spread = #TestTraceIsolate. In the US w/ 330 million people that'll be exceedingly difficult, no less with one-off testing which requires repetition every week. Add false negatives.","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":63,"likes_count":251,"hashtags":["#testtraceisolate"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1269359676128280576","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1269359672701534200,"conversation_id":"1269359663591510016","created_at":1591473904000,"date":"2020-06-06","time":"20:05:04","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"But viral load is not the same as transmissibility, which hasn't been adequately studied. Ideally with genomics of the virus for precision. The cohorts we reviewed certainly support spread and perhaps > 14 days (e.g. USS aircraft).\nA v large, random sample to study this is needed","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":62,"likes_count":258,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1269359672701534209","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1269359667127259100,"conversation_id":"1269359663591510016","created_at":1591473902000,"date":"2020-06-06","time":"20:05:02","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"This 40-45% rate is striking for being so high and it's hard to come up with another pathogen with the spectrum: from no symptoms to being lethal.\nBut it's also notable that \"silent\" infections may not be so silent after all","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":61,"likes_count":251,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1269359667127259136","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1269359666359754800,"conversation_id":"1269359663591510016","created_at":1591473902000,"date":"2020-06-06","time":"20:05:02","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The representative samples help establish that the rate of having a #COVID19 infection but not having symptoms is about 40-45%\nThe longitudinal (serial) assessment helps anchor that rate since 0-10% turned out to convert, with only 1 exception, the  Kings County nursing facility","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":70,"likes_count":233,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1269359666359754752","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1268618780952785000,"conversation_id":"1268615583395807233","created_at":1591297261000,"date":"2020-06-04","time":"19:01:01","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The \"only\" major difference from the retracted paper v. prior/other 14 studies (10 observational, 4 RCTs) was the ~35% increase in mortality. Otherwise, there was consistency in lack of efficacy (and risk of heart arrhythmias in many).\nNow there's no data to support ⬆️ mortality","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":54,"likes_count":141,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1268618780952784901","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1268289977055510500,"conversation_id":"1268261242470187008","created_at":1591218868000,"date":"2020-06-03","time":"21:14:28","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"There's also a lot of data about children from the 16 cohorts.\nOne of the most careful studies was in Vo, Italy:\n“No infections were detected in either survey in 234 tested children ranging from 0 to 10 years, despite some of them living in the same household as infected people”","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":25,"likes_count":70,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1268289977055510528","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1268288408650002400,"conversation_id":"1268261242470187008","created_at":1591218494000,"date":"2020-06-03","time":"21:08:14","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Besides the high rate of people infected but lacking symptoms, it is noteworthy what is going on beneath the surface. For example: \n1 cohort of 331 (46.5%) were asymptomatic. But CT scans in 76 of these individuals, 54% showed significant abnormalities c/w #COVID19.","mentions":[],"urls":[],"photos":[],"replies_count":7,"retweets_count":37,"likes_count":89,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1268288408650002432","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1268200827610493000,"conversation_id":"1268198963875725313","created_at":1591197613000,"date":"2020-06-03","time":"15:20:13","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Interpretation in context: the mystery that multi-system inflammatory syndrome (Kawasaki-like) has had few, if any publications, from China but many reports throughout Europe and the US. Previously, post-viral Kawasaki disease well known to be more frequent among Asian children","mentions":[],"urls":[],"photos":[],"replies_count":2,"retweets_count":10,"likes_count":50,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1268200827610492933","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1268162733574242300,"conversation_id":"1268159866624815105","created_at":1591188531000,"date":"2020-06-03","time":"12:48:51","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"And Anders Tegneli deserves credit for acknowledging the mistake, something we haven’t seen in the US where tens of thousands of deaths occurred that were preventable","mentions":[],"urls":[],"photos":[],"replies_count":16,"retweets_count":52,"likes_count":292,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1268162733574242305","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1267895421331886000,"conversation_id":"1267561494331273216","created_at":1591124799000,"date":"2020-06-02","time":"19:06:39","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"For those not familiar with the medical use of \"masked facies\"\nor hypomimia: \"the loss of facial expressions\"\n\"It is so named because the condition gives the affected person a fixed, mask-like expression.\"\nThat's why this play on words with art is especially clever","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":5,"likes_count":39,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1267895421331886080","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1267151703092023300,"conversation_id":"1267151689515032577","created_at":1590947483000,"date":"2020-05-31","time":"17:51:23","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"But I think the bottom line is we don't know.\nThere needs to be more and better data to chase this down before anyone can proclaim that reopening schools is perfectly safe.","mentions":[],"urls":[],"photos":[],"replies_count":30,"retweets_count":66,"likes_count":246,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1267151703092023297","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1265825566957035500,"conversation_id":"1265727806916321280","created_at":1590631307000,"date":"2020-05-28","time":"02:01:47","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"BTW France banned the drug today for use in #COVID19 patients","mentions":[],"urls":[],"photos":[],"replies_count":7,"retweets_count":30,"likes_count":123,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1265825566957035520","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1265271855121789000,"conversation_id":"1265270763600244737","created_at":1590499292000,"date":"2020-05-26","time":"13:21:32","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"This impressive #3D structure and function work of human neutralizing antibodies (nAbs) helps get us to ones that can be synthetically manufactured for both prevention and treatment. And for knowledge of the templates that predict  effective vaccines.","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":27,"likes_count":78,"hashtags":["#3d"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1265271855121788929","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1264652928041668600,"conversation_id":"1264652928041668608","created_at":1590351728000,"date":"2020-05-24","time":"20:22:08","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Preventive medicine in the US, never a strength, parallels its virtual lack of #TestTraceIsolate to get ahead of #COVID19. Some countries started testing well before their 1st patient.\nNow it relies on its forte to repurpose/new drugs, neutralizing antibodies & vaccines, a rescue","mentions":[],"urls":[],"photos":[],"replies_count":9,"retweets_count":27,"likes_count":95,"hashtags":["#testtraceisolate","#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1264652928041668608","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263964116483371000,"conversation_id":"1263958776169693184","created_at":1590187503000,"date":"2020-05-22","time":"22:45:03","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Review of the data supports the drug's potential for promoting survival.\nFor all patients enrolled, the 30%⬇️ deaths is consistent in direction and magnitude as the ⬆️ 27% recovery time.\nPatients w/ most severe baseline status derived no benefit.","mentions":[],"urls":[],"photos":[],"replies_count":12,"retweets_count":50,"likes_count":174,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263964116483371008","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263925629482709000,"conversation_id":"1263925629482708993","created_at":1590178327000,"date":"2020-05-22","time":"20:12:07","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"A note about the world's worst super-spreader events:\n3 of the worst were from churches\nSouth Korea (Feb 9/16) >5,000 cases\nFrance (Feb 17) > 2,500 cases\nUS (March 10) 53 cases","mentions":[],"urls":[],"photos":[],"replies_count":85,"retweets_count":1120,"likes_count":2187,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263925629482708993","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263896317782179800,"conversation_id":"1263811764287725574","created_at":1590171338000,"date":"2020-05-22","time":"18:15:38","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Just 2 footnotes\n1. This report is >6X the N of Rx'd patients cumulatively reported on cf prior studies (includes 3=RCTs)\n2. The addition of a macrolide antibiotic (1 of which was azithromycin) added substantially to risk of ventricular tachycardia: HCQ 2.3X-> H+M 5.1X risk","mentions":[],"urls":[],"photos":[],"replies_count":13,"retweets_count":55,"likes_count":150,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263896317782179840","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263820223443898400,"conversation_id":"1263811764287725574","created_at":1590153196000,"date":"2020-05-22","time":"13:13:16","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"HCQ failed efficacy in the spectrum of mild to severe #COVID19, but now the higher mortality & VT in hospitalized patients (where arrhythmias get Dx'd and treated) raises 2 questions:\n1. Is it ethical to proceed with ongoing RCTs?\n2. How can the drug be given to outpatients?","mentions":[],"urls":[],"photos":[],"replies_count":47,"retweets_count":184,"likes_count":516,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263820223443898369","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263815704379142100,"conversation_id":"1263811764287725574","created_at":1590152119000,"date":"2020-05-22","time":"12:55:19","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The significant increase in deaths among HCQ of CQ treated patients cannot be directly attributed to the *2-5 fold increase*  in ventricular tachycardia (a malignant arrhythmia) but that must be playing a role.","mentions":[],"urls":[],"photos":[],"replies_count":18,"retweets_count":140,"likes_count":460,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263815704379142145","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263813148055724000,"conversation_id":"1263811764287725574","created_at":1590151509000,"date":"2020-05-22","time":"12:45:09","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"It's no longer that hydroxychloroquine has no sign of efficacy—it  is associated with an increase in mortality. \nThis is not a randomized trial but larger than all the preceding 10 studies and 3 randomized trials in aggregate. \nChloroquine was even worse for risk than HCQ.","mentions":[],"urls":[],"photos":[],"replies_count":55,"retweets_count":594,"likes_count":1311,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263813148055724032","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263582603166154800,"conversation_id":"1263581371156492290","created_at":1590096543000,"date":"2020-05-21","time":"21:29:03","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"We've known Kawasaki disease is more common in Asian children (pre-covid19) but was not reported from China in the pandemic before it appeared in Italy, UK and Europe.\nAdds to the mystery.","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":21,"likes_count":58,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263582603166154760","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1263166603656487000,"conversation_id":"1263164966095302657","created_at":1589997361000,"date":"2020-05-20","time":"17:56:01","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"All I see is serpentine and I have ophidiophobia 😨","mentions":[],"urls":[],"photos":[],"replies_count":19,"retweets_count":6,"likes_count":184,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1263166603656486913","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1262468365634830300,"conversation_id":"1262441494662639616","created_at":1589830888000,"date":"2020-05-18","time":"19:41:28","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Multiple responses, w/ various links/papers, suggest the risk of getting #COVID19 reduced (protection from) but when active smokers do get infected their outcomes are significantly worse.  Mechanism for the former is unknown. The new paper sheds some light on the latter.","mentions":[],"urls":[],"photos":[],"replies_count":10,"retweets_count":18,"likes_count":77,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1262468365634830336","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1262360249551294500,"conversation_id":"1262358733687906305","created_at":1589805111000,"date":"2020-05-18","time":"12:31:51","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Correction: I botched Barry's last name. It's Blitt.","mentions":[],"urls":[],"photos":[],"replies_count":0,"retweets_count":3,"likes_count":26,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1262360249551294466","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1262089677462364200,"conversation_id":"1262083005012561922","created_at":1589740602000,"date":"2020-05-17","time":"18:36:42","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Our >30% estimate is actually conservative, acknowledging that 12/14 cohorts with >40% must be admixed with pre-symptomatics.\nThe real % is important beyond spread concerns. We know from the Diamond Princess that people w/o symptoms had significant lung injury by CT scans 5/x","mentions":[],"urls":[],"photos":[],"replies_count":9,"retweets_count":20,"likes_count":60,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1262089677462364161","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1261692921834684400,"conversation_id":"1261689347335577601","created_at":1589646008000,"date":"2020-05-16","time":"16:20:08","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"3. Many hypotheses have been for these remarkable data including lack of testing and reporting, the lag of cases with later #SARSCoV2 arrival to the continent, the younger population.","mentions":[],"urls":[],"photos":[],"replies_count":6,"retweets_count":26,"likes_count":85,"hashtags":["#sarscov2"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1261692921834684422","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1261358911451312000,"conversation_id":"1252399471251451908","created_at":1589566374000,"date":"2020-05-15","time":"18:12:54","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"How many times do we need to replicate this experiment?","mentions":[],"urls":[],"photos":[],"replies_count":21,"retweets_count":9,"likes_count":60,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1261358911451312129","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1261006208913117200,"conversation_id":"1261004803607425024","created_at":1589482283000,"date":"2020-05-14","time":"18:51:23","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"It sure makes you wonder how many, what % of the  #healthcare workforce have asymptomatically dealt with an infection and begs the need for antibody testing at scale","mentions":[],"urls":[],"photos":[],"replies_count":8,"retweets_count":22,"likes_count":82,"hashtags":["#healthcare"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1261006208913117184","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1260968538442920000,"conversation_id":"1260585285655592962","created_at":1589473301000,"date":"2020-05-14","time":"16:21:41","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Correction: that should be 4 monoclonal antibodies with different epitopes from 1 patient","mentions":[],"urls":[],"photos":[],"replies_count":0,"retweets_count":2,"likes_count":13,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1260968538442919936","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1260580772756496400,"conversation_id":"1260579025812172800","created_at":1589380851000,"date":"2020-05-13","time":"14:40:51","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"This estimate of infection rate and, correspondingly seroprevalence, is similar to the US (somewhat lower here but in the range). It emphasizes the high proportion of people still at risk as mitigation strategies are relaxed","mentions":[],"urls":[],"photos":[],"replies_count":7,"retweets_count":51,"likes_count":135,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1260580772756496384","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1260352238905634800,"conversation_id":"1260352238905634816","created_at":1589326364000,"date":"2020-05-12","time":"23:32:44","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"How the anti-truth \"bots\" are programmed\n—It's all China's fault; all their data are lies\n—The US is best at testing in the world\n—The US is over-counting deaths\n—US performance is great, just adjust per capita\n—#COVID19 only affects elderly, fine to reopen\n—use foul language","mentions":[],"urls":[],"photos":[],"replies_count":34,"retweets_count":146,"likes_count":392,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1260352238905634816","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258887702516097000,"conversation_id":"1258886910920912896","created_at":1588977191000,"date":"2020-05-08","time":"22:33:11","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"A good way to wind up the week. More hope of finding effective therapies against #SARSCoV2. And in a published paper. We're going to beat this sucker virus, eventually.","mentions":[],"urls":[],"photos":[],"replies_count":8,"retweets_count":34,"likes_count":270,"hashtags":["#sarscov2"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258887702516097024","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258761141662003200,"conversation_id":"1258759911275548674","created_at":1588947017000,"date":"2020-05-08","time":"14:10:17","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Estimate of infection rate is wide, from 2-8% country-wide, yet to be established without a seroprevalence study from a random, large sample and test with 99.9+% specificity","mentions":[],"urls":[],"photos":[],"replies_count":0,"retweets_count":15,"likes_count":41,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258761141662003202","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258759911275548700,"conversation_id":"1258759911275548674","created_at":1588946724000,"date":"2020-05-08","time":"14:05:24","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"United States, May 8, impact of #COVID19:\n14.7% unemployment\n~5% infection rate \n2.5% covid-19 tested\n0.38% confirmed cases\n0.02% confirmed deaths\n-------------\nThe collateral damage is disproportionate to the direct viral hit; the confirmed cases and deaths underestimate true N","mentions":[],"urls":[],"photos":[],"replies_count":13,"retweets_count":71,"likes_count":136,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258759911275548674","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258238507685798000,"conversation_id":"1258238507685797888","created_at":1588822411000,"date":"2020-05-07","time":"03:33:31","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"How can a country that has required you to take your shoes off at airport security for a 2001 foiled attempt without a single person hurt ......\nbe the same one that has no systematic plan to address >73,000 Americans dead, >1.2 million confirmed cases?","mentions":[],"urls":[],"photos":[],"replies_count":582,"retweets_count":5740,"likes_count":17810,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258238507685797888","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258176597837807600,"conversation_id":"1258171469072236544","created_at":1588807651000,"date":"2020-05-06","time":"23:27:31","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"I cannot remember a single day in which we didn't learn something/a lot significant about #SARSCoV2 or the human impact of #COVID19 over many weeks. It's humbling and, at the same time, shows how much room there is for improvement in understanding and progress.\nToward prevailing.","mentions":[],"urls":[],"photos":[],"replies_count":13,"retweets_count":109,"likes_count":402,"hashtags":["#sarscov2","#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258176597837807621","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258045493394858000,"conversation_id":"1257804965126406144","created_at":1588776393000,"date":"2020-05-06","time":"14:46:33","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"By protecting people and gaining time, we can build on the initial drug efficacy success, along w/ convalescent sera, neutralizing antibodies. I'm optimistic we'll see lower fatality rates in the months ahead, no less maintain hope for a vaccine. We need an active approach. 2/2","mentions":[],"urls":[],"photos":[],"replies_count":23,"retweets_count":70,"likes_count":374,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258045493394857984","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1258044264736415700,"conversation_id":"1257804965126406144","created_at":1588776100000,"date":"2020-05-06","time":"14:41:40","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"I posted the letter w/o (holding back from) expressing my view. Now let me say I believe his rationale of \"playing dead\" to accept the death toll is a defeatist, nihilistic, mea culpa to the virus. We can surely do better than this. 1/2","mentions":[],"urls":[],"photos":[],"replies_count":18,"retweets_count":90,"likes_count":401,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1258044264736415746","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1257026074820481000,"conversation_id":"1257026074820481025","created_at":1588533345000,"date":"2020-05-03","time":"19:15:45","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"A bureaupathic country w/ 3+ trillion $ to dig out from its BIG outbreak miss.\nTake 2, let's miss again.\nWith no plan:\n—Accurate, massive testing (virus + Ab) w/ rapid turnaround\n—Hire x00,000 contact tracers (w/ > 30 million unemployed)\n— #TestTraceIsolate \n—Digital surveillance","mentions":[],"urls":[],"photos":[],"replies_count":6,"retweets_count":55,"likes_count":114,"hashtags":["#testtraceisolate"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1257026074820481025","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1256716230301384700,"conversation_id":"1256715718260711424","created_at":1588459472000,"date":"2020-05-02","time":"22:44:32","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The US also has company with India, Brazil and Russia as the only major countries not improving.\nBesides the US, the hardest hit ones (UK, France Spain, Italy) are all, fortunately,  on the descent.","mentions":[],"urls":[],"photos":[],"replies_count":11,"retweets_count":86,"likes_count":195,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1256716230301384704","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1256625718965854200,"conversation_id":"1256622578908581889","created_at":1588437893000,"date":"2020-05-02","time":"16:44:53","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The secondary attack rate among contacts:\nShenzhen: Household contacts 11.2%\nTaiwan: Household contacts 4.6%\nAnother way to look at this is that most household contacts did not get infected 4/x","mentions":[],"urls":[],"photos":[],"replies_count":5,"retweets_count":15,"likes_count":43,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1256625718965854208","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255573025472143400,"conversation_id":"1255539949471854592","created_at":1588186911000,"date":"2020-04-29","time":"19:01:51","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"That's 11.6 reduced to 8.0%, adding to my list of infamous typos :-(","mentions":[],"urls":[],"photos":[],"replies_count":9,"retweets_count":5,"likes_count":68,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255573025472143360","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255539949471854600,"conversation_id":"1255539949471854592","created_at":1588179025000,"date":"2020-04-29","time":"16:50:25","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The new remdesivir data from Tony Fauci from N >1,000 placebo-controlled trial (unpublished, Oval Office citation) does not show statistically significant reduction in mortality (8% vs 11%, in the right direction) but a clear-cut benefit in time to recovery 11 vs 15 days, P<0.001","mentions":[],"urls":[],"photos":[],"replies_count":99,"retweets_count":957,"likes_count":2114,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255539949471854592","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255497679322460200,"conversation_id":"1255320775231524864","created_at":1588168947000,"date":"2020-04-29","time":"14:02:27","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"For the per capita aficionados: \nThe US has 800% more confirmed cases than expected\nand >600% more deaths\nAdjustment for inaccurate counts of cases or deaths outside the US unlikely to materially change these estimates (the US has significant issues with this, too)","mentions":[],"urls":[],"photos":[],"replies_count":10,"retweets_count":37,"likes_count":53,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255497679322460161","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255366460941250600,"conversation_id":"1255366061106647040","created_at":1588137662000,"date":"2020-04-29","time":"05:21:02","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"So glad it helped you 🙏","mentions":[],"urls":[],"photos":[],"replies_count":0,"retweets_count":0,"likes_count":0,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255366460941250566","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255324993988300800,"conversation_id":"1255320775231524864","created_at":1588127776000,"date":"2020-04-29","time":"02:36:16","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"my calculations based on\nconfirmed cases\n1034588\n3113447\n33.2%\ndeaths\n58955\n216930\n27.2%\npopulation\n328,000,000\n7,800,000,000\n4.2%","mentions":[],"urls":[],"photos":[],"replies_count":9,"retweets_count":22,"likes_count":67,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255324993988300801","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255182728309272600,"conversation_id":"1255178668227231744","created_at":1588093857000,"date":"2020-04-28","time":"17:10:57","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"5. Any thinking that infants or children, on an absolute basis, cannot get extremely ill or die is flawed-just that it's very low. It cannot be predicted. \nFurther, their potential role as asymptomatic carriers needs to be respected and taken into account for reopening strategies","mentions":[],"urls":[],"photos":[],"replies_count":10,"retweets_count":45,"likes_count":110,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255182728309272576","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1255179654001918000,"conversation_id":"1255178668227231744","created_at":1588093124000,"date":"2020-04-28","time":"16:58:44","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"3. All of the studies to date suggest that viral load in individuals who are infected w/ #COVID19 are similar, irrespective of symptomatic status\nThat also suggests that many children are capable of being asymptomatic carriers for spread","mentions":[],"urls":[],"photos":[],"replies_count":4,"retweets_count":32,"likes_count":90,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1255179654001917952","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1254963962761769000,"conversation_id":"1254963379162112003","created_at":1588041699000,"date":"2020-04-28","time":"02:41:39","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"w/ isolated fever (not server)","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":8,"likes_count":26,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1254963962761768963","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1254907013110235100,"conversation_id":"1254900753644138496","created_at":1588028121000,"date":"2020-04-27","time":"22:55:21","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"2 things to add:\nCorrecting a typo-Only 11% of close contacts DID get infected (surprisingly low, yes)\nAnd the story with children, getting infected with mild or no symptoms, as an unwitting vector of spread (see Figure)","mentions":[],"urls":[],"photos":[],"replies_count":5,"retweets_count":16,"likes_count":47,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1254907013110235136","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1254834703426678800,"conversation_id":"1254833966156091394","created_at":1588010881000,"date":"2020-04-27","time":"18:08:01","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"And for those who challenged why such a question would be asked: we are trained to determine whether any patient death or significant morbidity was preventable and to learn from it.","mentions":[],"urls":[],"photos":[],"replies_count":5,"retweets_count":4,"likes_count":33,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1254834703426678785","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1254625675085922300,"conversation_id":"1254616955920592896","created_at":1587961045000,"date":"2020-04-27","time":"04:17:25","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Collectively, along w/ the totality of evidence since #COVID19 hit, the risk for healthy, young people, while lower than the aged, is FAR from zero and cannot be predicted. Moving \"low risk\" reentry forward, w/o vast testing & tight surveillance, will lead to substantial deaths","mentions":[],"urls":[],"photos":[],"replies_count":26,"retweets_count":88,"likes_count":261,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1254625675085922304","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1253803217328074800,"conversation_id":"1253800347765665793","created_at":1587764956000,"date":"2020-04-24","time":"21:49:16","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"5. So now test, test, test has some holes. We desperately need to do them but can't do them at the scale or frequency we need for the US population and geography; the accuracy can't be fully relied upon. The virus test is a one-off assessment. How can we be smarter about this?","mentions":[],"urls":[],"photos":[],"replies_count":5,"retweets_count":13,"likes_count":36,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1253803217328074752","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1253802474600685600,"conversation_id":"1253800347765665793","created_at":1587764779000,"date":"2020-04-24","time":"21:46:19","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"4. Relying on the serology tests sets up other problems. There is a significant false positive rate and lack of validation of any at scale, especially in populations w/ low infection rates.\nMoreover, we don't know if IgG antibody protects: (1)against spread and (2) for how long?","mentions":[],"urls":[],"photos":[],"replies_count":2,"retweets_count":24,"likes_count":51,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1253802474600685573","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1253801717486899200,"conversation_id":"1253800347765665793","created_at":1587764598000,"date":"2020-04-24","time":"21:43:18","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"3. Besides practical limitations of doing tests for >330 million people, once is not enough. A negative test could turn positive the next day. There is a major issue still w/ false negatives. Testing every week (or more frequent) would be ideal, but that's even more impractical.","mentions":[],"urls":[],"photos":[],"replies_count":2,"retweets_count":15,"likes_count":49,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1253801717486899200","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1253801249738068000,"conversation_id":"1253800347765665793","created_at":1587764487000,"date":"2020-04-24","time":"21:41:27","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"2. We need a massive number of tests now, daily, but it has taken the US several weeks just to get to <5 million total. Even with the recruitment of academic & industry labs (as we advocated), it'll take time & the big N of tests, while desirable, are ambitious, to say the least.","mentions":[],"urls":[],"photos":[],"replies_count":1,"retweets_count":11,"likes_count":34,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1253801249738067968","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1253692162916577300,"conversation_id":"1253692162916577280","created_at":1587738478000,"date":"2020-04-24","time":"14:27:58","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"We've now lost over 50,000 Americans from #COVID19.\nWhat % were preventable by early and aggressive testing, isolation and contact tracing?","mentions":[],"urls":[],"photos":[],"replies_count":38,"retweets_count":58,"likes_count":69,"hashtags":["#covid19"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1253692162916577280","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1253492057454153700,"conversation_id":"1253489498836492288","created_at":1587690769000,"date":"2020-04-24","time":"01:12:49","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"The plateau hypothesis has been refuted.","mentions":[],"urls":[],"photos":[],"replies_count":13,"retweets_count":31,"likes_count":122,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1253492057454153728","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1252360658974195700,"conversation_id":"1252356183077208082","created_at":1587421023000,"date":"2020-04-20","time":"22:17:03","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Yes,  some patients in these series were actually pre-symptomatic, but those data were not reported. The advantage of the Vo, Italy study was a sequential assessment which ruled that out; the asymptomatic rate was 43%","mentions":[],"urls":[],"photos":[],"replies_count":15,"retweets_count":29,"likes_count":132,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1252360658974195717","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1252065352227250200,"conversation_id":"1252060564743794689","created_at":1587350616000,"date":"2020-04-20","time":"02:43:36","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"A fatality search and recovery team of~400 members from the New York Air National Guard put on #PPE and go into homes and long-term care facilities: the number dying at home and outside a hospital setting is about 4 times the norm","mentions":[],"urls":[],"photos":[],"replies_count":3,"retweets_count":76,"likes_count":162,"hashtags":["#ppe"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1252065352227250176","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1251976104207777800,"conversation_id":"1251974424170913794","created_at":1587329338000,"date":"2020-04-19","time":"20:48:58","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"This is the real #CrushTheCurve and inspiring to see how many countries are capable of achieving it","mentions":[],"urls":[],"photos":[],"replies_count":7,"retweets_count":19,"likes_count":88,"hashtags":["#crushthecurve"],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1251976104207777792","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1251876162101338000,"conversation_id":"1251872896080732160","created_at":1587305510000,"date":"2020-04-19","time":"14:11:50","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Multiple studies, including yesterday's Vo, Italy preprint, have shown that the viral load (and presumably shedding/spread capacity) is similar irrespective of symptom status. \nWhile we don't have a large-scale random assessment, this 40% estimate emphasizes the challenge ahead","mentions":[],"urls":[],"photos":[],"replies_count":15,"retweets_count":103,"likes_count":211,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1251876162101338112","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1251528874116051000,"conversation_id":"1251282736343429126","created_at":1587222710000,"date":"2020-04-18","time":"15:11:50","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Noting that this is a comparison of infection prevalence in Washington vs antibody prevalence (a cumulative metric) in California. Also note that seropositive rate in Wuhan of 2-3% strongly points against Santa Clara county report. Both offered as external data reference points.","mentions":[],"urls":[],"photos":[],"replies_count":2,"retweets_count":12,"likes_count":29,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1251528874116050950","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1251318477618425900,"conversation_id":"1251266544178302978","created_at":1587172548000,"date":"2020-04-18","time":"01:15:48","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"No testing once, shame on you; no testing twice, shame on me","mentions":[],"urls":[],"photos":[],"replies_count":11,"retweets_count":34,"likes_count":176,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1251318477618425856","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1250876913813524500,"conversation_id":"1250871970045952000","created_at":1587067271000,"date":"2020-04-16","time":"20:01:11","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Let's do a poll 🤔","mentions":[],"urls":[],"photos":[],"replies_count":10,"retweets_count":4,"likes_count":13,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1250876913813524482","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
{"id":1249366000132165600,"conversation_id":"1249357423158026241","created_at":1586707041000,"date":"2020-04-12","time":"15:57:21","timezone":"UTC","user_id":86626845,"username":"erictopol","name":"Eric Topol","place":"","tweet":"Please note: All of these apps are OPT IN meant to supplement classic, laborious, physical contact tracing by people.","mentions":[],"urls":[],"photos":[],"replies_count":5,"retweets_count":7,"likes_count":29,"hashtags":[],"cashtags":[],"link":"https://twitter.com/EricTopol/status/1249366000132165632","retweet":false,"quote_url":"","video":0,"near":"","geo":"","source":"","user_rt_id":"","user_rt":"","retweet_id":"","reply_to":[{"user_id":"86626845","username":"EricTopol"}],"retweet_date":"","translate":"","trans_src":"","trans_dest":""}
