# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Slc1a3 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (17)
- Disease (1)

Name: Excitatory amino acid transporter 1 (Slc1a3)
Official Symbol: SLC1A3 provided by HGNC
Function:
Transports L-glutamate and also L-and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 6507 | P43003 |  |  | MINT-5004226 | 112398 | P43003 |  | hsa:6507 | 600111
Mouse | 20512 | P56564 |  | P56564 |  | 203291 | P56564 |  | mmu:20512 |
Rat | 29483 | P24942 |  |  |  | 248125 | P24942 |  | rno:29483 |

PPI pairs:

TRPC3

Biological Process:

- GO:0031223 : auditory behavior
- GO:0048667 : cell morphogenesis involved in neuron differentiation
- GO:0021545 : cranial nerve development
- GO:0070779 : D-aspartate import
- GO:0009449 : gamma-aminobutyric acid biosynthetic process
- GO:0006537 : glutamate biosynthetic process
- GO:0051938 : L-glutamate import
- GO:0043490 : malate-aspartate shuttle
- GO:0050885 : neuromuscular process controlling balance
- GO:0001504 : neurotransmitter uptake
- GO:0050806 : positive regulation of synaptic transmission
- GO:0046677 : response to antibiotic
- GO:0042493 : response to drug
- GO:0010035 : response to inorganic substance
- GO:0009416 : response to light stimulus
- GO:0009611 : response to wounding
- GO:0007605 : sensory perception of sound

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:600111 : Episodic ataxia, type 6 (OMIM:612656 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | Slc1a3 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.