# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPV3 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (4)
- Biological Process (2)
- Disease (1)

Name: Transient receptor potential cation channel subfamily V member 3 (TRPV3)
Official Symbol: TRPV3 provided by HGNC
Function:
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 162514 | Q8NET8 |  |  |  | 127821 | Q8NET8 | 509 | hsa:162514 | 607066
Mouse | 246788 | Q8K424 | DIP-55952N | Q8K424 |  | 232951 | Q8K424 |  | mmu:246788 |
Rat | 497948 | Q4QYD9 |  |  |  | 269258 | Q4QYD9 |  | rno:497948 |

PPI pairs:

AKAP5/AKAP150 | Calmodulin | EGFR | TRPV1

Biological Process:

- GO:0042636 : negative regulation of hair cycle
- GO:0009266 : response to temperature stimulus

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:607066 : Olmsted syndrome (OMIM:614594 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV3 |  | AKAP5/AKAP150 | Speculation |  |  |  |  |  | Prediction | 18701070
TRPV3 |  | Calmodulin | Inference |  |  |  |  |  | Prediction | 19864432
TRPV3 |  | EGFR | Inference |  |  |  |  |  | Prediction | 20403327
TRPV3 |  | TRPV1 | Inference |  |  |  |  |  | Prediction | 12077606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPV3 |  | Calmodulin | Fusion protein-pull down assay | Mouse | ARD domain | Not specified | Not determined | Not specified | In vitro translation | 20926660

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV3 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 18701070
TRPV3 |  | EGFR | Co-immunoprecipitation | TRPV3-YFP transgenic mouse skin tissue |  |  |  |  |  | 20403327
TRPV3 |  | TRPV1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 12077606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV3 |  | Calmodulin | Fusion protein-pull down assay | Mouse | ARD domain | Not specified | Not determined |  |  | 20926660
TRPV3 |  | Calmodulin | Fusion protein-pull down assay | Human | 115-367 | Not specified | Not determined |  |  | 19864432

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV3 |  | EGFR | Calcium measurement |  |  | Activation | 20403327

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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