# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Myosin-10 / TRP channels

- Basic Information
- External Database
- PPI pairs (3)
- Biological Process (20)
- Disease (0)

Name: Myosin-10 (Myosin-10)
Official Symbol: MYH10 provided by HGNC
Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4628 | P35580 | DIP-31110N | P35580 | MINT-1133516 | 110713 | P35580 |  | hsa:4628 | 160776
Mouse | 77579 | Q61879 | DIP-31956N | Q61879 | MINT-4102674 | 218774 | Q61879 |  | mmu:77579 |
Rat | 79433 | Q9JLT0 |  |  | MINT-4568339 | 249464 | Q9JLT0 |  | rno:79433 |

PPI pairs:

TRPC3 | TRPC5 | TRPV4

Biological Process:

- GO:0030048 : actin filament-based movement
- GO:0007512 : adult heart development
- GO:0007411 : axon guidance
- GO:0055003 : cardiac myofibril assembly
- GO:0008283 : cell proliferation
- GO:0021680 : cerebellar Purkinje cell layer development
- GO:0000281 : cytokinesis after mitosis
- GO:0006887 : exocytosis
- GO:0021592 : fourth ventricle development
- GO:0001701 : in utero embryonic development
- GO:0021670 : lateral ventricle development
- GO:0050885 : neuromuscular process controlling balance
- GO:0001764 : neuron migration
- GO:0007097 : nuclear migration
- GO:0001778 : plasma membrane repair
- GO:0008360 : regulation of cell shape
- GO:0060041 : retina development in camera-type eye
- GO:0006930 : substrate-dependent cell migration, cell extension
- GO:0021678 : third ventricle development
- GO:0055015 : ventricular cardiac muscle cell development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | Myosin-10 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC5 |  | Myosin-10 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPV4 |  | Myosin-10 | Affinity purification-mass spectrometry | Mouse | Full-length | Human | HEK293 | Cell lystaes |  | 22492541

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV4 |  | Myosin-10 | Co-immunofluorescence staining |  | HEK293 | Mouse | Full-length | Not used |  | 22492541

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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