# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# RGS2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (13)
- Disease (0)

Name: Regulator of G-protein signaling 2 (RGS2)
Official Symbol: RGS2 provided by HGNC
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5997 | P41220 | DIP-44289N | P41220 | MINT-1380095 | 111929 | P41220 |  | hsa:5997 | 600861
Mouse | 19735 | O08849 | DIP-44292N |  | MINT-4953705 | 202883 | O08849 |  | mmu:19735 |
Rat | 84583 | Q9JHX0 |  |  | UNK-5548718 | 250014 | Q9JHX0 |  | rno:84583 |

PPI pairs:

TRPV6

Biological Process:

- GO:0050873 : brown fat cell differentiation
- GO:0007049 : cell cycle
- GO:0010614 : negative regulation of cardiac muscle hypertrophy
- GO:0045744 : negative regulation of G-protein coupled receptor protein signaling pathway
- GO:0043407 : negative regulation of MAP kinase activity
- GO:0010519 : negative regulation of phospholipase activity
- GO:0060452 : positive regulation of cardiac muscle contraction
- GO:0071877 : regulation of adrenergic receptor signaling pathway
- GO:0006417 : regulation of translation
- GO:0055119 : relaxation of cardiac muscle
- GO:0060087 : relaxation of vascular smooth muscle
- GO:0007283 : spermatogenesis
- GO:0038032 : termination of G-protein coupled receptor signaling pathway

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV6 |  | RGS2 | Yeast two-hybrid | Mouse | 1-326 | Mouse | Kidney | cDNA library |  | 16895908

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPV6 |  | RGS2 | Fusion protein-pull down assay | Mouse | Full-length | HEK293 lysates | Human | Full-length | E. coli | 16895908

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV6 |  | RGS2 | Patch clamp |  |  | Inhibition | 16895908

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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