# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# NMDAR1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (8)
- Disease (1)

Name: Glutamate receptor ionotropic, NMDA 1 (NMDAR1)
Official Symbol: GRIN1 provided by HGNC
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 2902 | Q05586 | DIP-36736N | Q05586 | MINT-1900224 | 109159 | Q05586 |  | hsa:2902 | 138249
Mouse | 14810 | P35438 | DIP-31577N | P35438 | MINT-135802 | 200067 | P35438 |  | mmu:14810 |
Rat | 24408 | P35439 | DIP-674N | P35439 | MINT-101336 | 246573 | P35439 |  | rno:24408 |

PPI pairs:

TRPV1

Biological Process:

- GO:0055074 : calcium ion homeostasis
- GO:0070588 : calcium ion transmembrane transport
- GO:0035235 : ionotropic glutamate receptor signaling pathway
- GO:2000463 : positive regulation of excitatory postsynaptic membrane potential
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0018964 : propylene metabolic process
- GO:0045471 : response to ethanol
- GO:0008542 : visual learning

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:138249 : Mental retardation, autosomal dominant 8 (OMIM:614254 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | NMDAR1 | Inference |  |  |  |  |  | Prediction | 22609428

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | NMDAR1 | Co-immunofluorescence staining | Rat trigeminal ganglia lysates |  |  |  |  |  | 22609428
TRPV1 |  | NMDAR1 | Co-immunoprecipitation | Rat trigeminal ganglia lysates |  |  |  |  |  | 22609428

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.