# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPV1 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (94)
- Biological Process (3)
- Disease (0)

Name: Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Official Symbol: TRPV1 provided by HGNC
Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 7442 | Q8NER1 |  |  | MINT-4721979 | 113281 | Q8NER1 | 507 | hsa:7442 | 602076
Mouse | 193034 | Q704Y3 | DIP-59791N |  | MINT-5185032 | 228724 | Q704Y3 |  | mmu:193034 |
Rat | 83810 | O35433 | DIP-46106N | O35433 | MINT-5117510 | 249845 | O35433 |  | rno:83810 |

PPI pairs:

80K-H | AKAP5/AKAP150 | AMPKơ2 | Actin | Akt | Apolipoprotein O | Bkca | CB1
CDK12 | CDK5 | CHERP | CaMKII | Calmodulin | Catenin-ơ2 | Catenin-Ƥ2 | Cbl
Contactin-1 | DAP-150 | DAZAP2 | E-cadherin | EGFR | Eferin/Rab11-FIP3 | FAF1 | GABARAP
GCN5 | Glucose 6 phosphatase | Glycogen phosphorylase | HAX-1 | ITM2C | JMJD2C | KCNQ2 | KCNQ3
KIF13B | KIF2A | KIF3B | KPNƢ1 | KvƢ2 | NKX2.2 | NMDAR1 | NMDAR2B
NOMO1 | Neuronatin | OS-9 | P2RX3 | PACS-1 | PEX10 | PI3K-p85ơ | PI3K-p85Ƣ
PIRT | PKA | PKARIIơ | PKC | PKCƢ | PKCƥ | PLAGL1 | PLCƣ1
POLR2G | POLR3D | PPARơ | PRKD1/PKCƬ | RAB26 | RAB8b | RANBP9 | RPL12
Ribosomal protein L9 | RyR1 | SGT | SMA3 | SNAPIN | Src | Synaptotagmin 1 | Synaptotagmin 4
TAK1 | TGS1 | TMEM115 | TRPA1 | TRPV2 | TRPV3 | Thrombospondin-3 | TrkA
Tubulin | UBP5 | ZBTB17 | ZO-1 | eNOS | snRNP 70 | ơ-tubulin-1A | ơ-tubulin-1B
ơENaC | ơII-spectrin | Ƣ-arrestin 2 | Ƣ-catenin | Ƣ-tubulin-3 | Ƣ-tubulin-5

Biological Process:

- GO:0007166 : cell surface receptor signaling pathway
- GO:0007635 : chemosensory behavior
- GO:0050955 : thermoception

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | 80K-H | Speculation |  |  |  |  |  | Prediction | 19801576
TRPV1 |  | Actin | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | AKAP5/AKAP150 | Inference |  |  |  |  |  | Prediction | 18381233
TRPV1 |  | Akt | Inference |  |  |  |  |  | Prediction | 21493704
TRPV1 |  | AMPKơ2 | Inference |  |  |  |  |  | Prediction | 22451268
TRPV1 |  | Apolipoprotein O | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | BKca | Inference |  |  |  |  |  | Prediction | 24147119
TRPV1 |  | Calmodulin | Inference |  |  |  |  |  | Prediction | 12808128
TRPV1 |  | CaMKII | Inference |  |  |  |  |  | Prediction | 21493704
TRPV1 |  | Catenin-ơ2 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | Catenin-Ƥ2 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | CB1 | Inference |  |  |  |  |  | Prediction | 23142606
TRPV1 |  | Cbl | Inference |  |  |  |  |  | Prediction | 19155296
TRPV1 |  | CDK12 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | CDK5 | Inference |  |  |  |  |  | Prediction | 17194758
TRPV1 |  | CHERP | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | Contactin-1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | DAP-150 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | DAZAP2 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | E-cadherin | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | E-cadherin | Inference |  |  |  |  |  | Prediction | 23345400
TRPV1 |  | Eferin/Rab11-FIP3 | Yeast two-hybrid | Rat | 684-820 | Mouse | Brain | cDNA library |  | 15883036
TRPV1 |  | EGFR | Inference |  |  |  |  |  | Prediction | 19155296
TRPV1 |  | eNOS | Inference |  |  |  |  |  | Prediction | 21493704
TRPV1 |  | FAF1 | Yeast two-hybrid | Rat | 243-440 | Rat | Sensory neuron | cDNA expression library |  | 16510717
TRPV1 |  | GABARAP | Yeast two-hybrid | Rat | 1-414 | Rat | Brain | cDNA library |  | 20179142
TRPV1 |  | GCN5 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | Glucose 6 phosphatase | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | Glycogen phosphorylase | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | Ƣ-arrestin 2 | Speculation |  |  |  |  |  | Prediction | 22952227
TRPV1 |  | Ƣ-catenin | Inference |  |  |  |  |  | Prediction | 23345400
TRPV1 |  | Ƣ-tubulin-3 | Inference |  |  |  |  |  | Prediction | 17298389
TRPV1 |  | Ƣ-tubulin-5 | Affinity purification-mass spectrometry | Rat | 681-838 | Rat | Spinal cord | Extract |  | 15569253
TRPV1 |  | HAX-1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | ITM2C | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | JMJD2C | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | KCNQ2 | Inference |  |  |  |  |  | Prediction | 21844219
TRPV1 |  | KCNQ3 | Inference |  |  |  |  |  | Prediction | 21844219
TRPV1 |  | KIF13B | Inference |  |  |  |  |  | Prediction | 23077056
TRPV1 |  | KIF2A | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | KIF3B | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | KPNƢ1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | KvƢ2 | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | Neuronatin | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | NKX2.2 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | NMDAR1 | Inference |  |  |  |  |  | Prediction | 22609428
TRPV1 |  | NMDAR2B | Inference |  |  |  |  |  | Prediction | 22609428
TRPV1 |  | NOMO1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | ơ-tubulin-1A | Inference |  |  |  |  |  | Prediction | 15569253
TRPV1 |  | ơ-tubulin-1B | Inference |  |  |  |  |  | Prediction | 22262838
TRPV1 |  | ơENaC | Inference |  |  |  |  |  | Prediction | 24890824
TRPV1 |  | ơII-spectrin | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | OS-9 | Inference |  |  |  |  |  | Prediction | 17932042
TRPV1 |  | P2RX3 | Inference |  |  |  |  |  | Prediction | 19223122
TRPV1 |  | PACS-1 | Inference |  |  |  |  |  | Prediction | 23159249
TRPV1 |  | PEX10 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | PI3K-p85Ƣ | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | PI3K-p85ơ | Inference |  |  |  |  |  | Prediction | 17074976
TRPV1 |  | PIRT | Inference |  |  |  |  |  | Prediction | 18455988
TRPV1 |  | PKA | Inference |  |  |  |  |  | Prediction | 12194871
TRPV1 |  | PKARIIơ | Inference |  |  |  |  |  | Prediction | 18463244
TRPV1 |  | PKC | Inference |  |  |  |  |  | Prediction | 14523239
TRPV1 |  | PKCƢ | Inference |  |  |  |  |  | Prediction | 24920628
TRPV1 |  | PKCƥ | Inference |  |  |  |  |  | Prediction | 11884385
TRPV1 |  | PLAGL1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | PLCƣ1 | Inference |  |  |  |  |  | Prediction | 15744307
TRPV1 |  | POLR2G | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | POLR3D | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | PPARơ | Inference |  |  |  |  |  | Prediction | 25014183
TRPV1 |  | PRKD1/PKCƬ | Inference |  |  |  |  |  | Prediction | 15471852
TRPV1 |  | RAB26 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | RAB8b | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | RANBP9 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | Ribosomal protein L9 | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | RPL12 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | RyR1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rabbit | Fast-twitch muscle | Triad vesicles |  | 18215135
TRPV1 |  | SGT | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | SMA3 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | SNAPIN | Yeast two-hybrid | Rat | 1-414 | Rat | Brain | cDNA library |  | 15066994
TRPV1 |  | SNAPIN | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | snRNP 70 | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | SRC | Inference |  |  |  |  |  | Prediction | 15084474
TRPV1 |  | Synaptotagmin 1 | Inference |  |  |  |  |  | Prediction | 15066994
TRPV1 |  | Synaptotagmin 4 | Yeast two-hybrid | Rat | 1-414 | Rat | Brain | cDNA library |  | 15066994
TRPV1 |  | TAK1 | Inference |  |  |  |  |  | Prediction | 23142606
TRPV1 |  | TGS1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | Thrombospondin-3 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | TMEM115 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | TrkA | Inference |  |  |  |  |  | Prediction | 11418861
TRPV1 |  | TRPA1 | Inference |  |  |  |  |  | Prediction | 20231274
TRPV1 |  | TRPV2 | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | TRPV2 | Inference |  |  |  |  |  | Prediction | 15713749
TRPV1 |  | TRPV3 | Inference |  |  |  |  |  | Prediction | 12077606
TRPV1 |  | UBP5 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | ZBTB17 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976
TRPV1 |  | ZO-1 | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPV1 |  | AKAP5/AKAP150 | Fusion protein-pull down assay | Human | 681-839 | E. coli | Not used |  | HEK293 lysates | 18701070
TRPV1 |  | Calmodulin | Fast performance liquid chromatography | Rat | 759-802 | E. coli | Human | Full-length | E. coli | 23109716
TRPV1 |  | Calmodulin | Fast performance liquid chromatography | Rat | 712?838 | E. coli | Mouse | Full-length | E. coli | 23119017
TRPV1 |  | Calmodulin | Fusion protein-pull down assay | Rat | N-terminus | E. coli | Not specified | Full-length | In vitro translation | 14699077
TRPV1 |  | Calmodulin | Fusion protein-pull down assay | Rat | C-terminus | E. coli | Bovine | Full-length | Not specified | 12808128
TRPV1 |  | Calmodulin | X-ray diffraction-structural analysis | Rat | 784-798 | E. coli | Human | Full-length | E. coli | 23109716
TRPV1 |  | Cbl | Fusion protein-pull down assay | Not specified | 680-838 | HEK293 lysates | Not used |  | A431 Human epithelial carcinoma cell line | 19155296
TRPV1 |  | Eferin/Rab11-FIP3 | Fusion protein-pull down assay | Rat | Full-length | HEK293T lysates | Mouse | Full-length | E. coli | 15883036
TRPV1 |  | EGFR | Fusion protein-pull down assay | Not specified | 680-838 | HEK293 lysates | Not used |  | A431 Human epithelial carcinoma cell line | 19155296
TRPV1 |  | FAF1 | Fusion protein-pull down assay | Rat | 1-440 | E. coli | Rat | Full-length | E. coli | 16510717
TRPV1 |  | GABARAP | Fusion protein-pull down assay | Not used |  | Rat brain lysates | Human | Full-length | E. coli | 20179142
TRPV1 |  | Ƣ-tubulin-3 | Fusion protein-pull down assay | Rat | 681-838 | E. coli | Not used |  | Pig brain tissue lysates | 17298389
TRPV1 |  | Ƣ-tubulin-5 | Fusion protein-pull down assay | Rat | 681-838 | E. coli | Rat | Full-length | Rat spinal cord extract | 15569253
TRPV1 |  | KIF13B | Co-immunoprecipitation | Rat | Full-length | CHO cell lysates | Rat | 1-557 | E. coli | 23077056
TRPV1 |  | ơ-tubulin-1A | Fusion protein-pull down assay | Rat | 681-838 | E. coli | Rat | Full-length | Rat spinal cord extract | 15569253
TRPV1 |  | PI3K-p85ơ | Fusion protein-pull down assay | Rat | Full-length | HEK293 lysates | Not specified | Full-length | E. coli | 17074976
TRPV1 |  | PLCƣ1 | Yeast two-hybrid | Rat | 761-835 | Yeast | Rat | 796-920 | Yeast | 15744307
TRPV1 |  | PRKD1/PKCƬ | Fusion protein-pull down assay | Rat | Full-length | E. coli | Not specified | Full-length | Not specified | 15471852
TRPV1 |  | SNAPIN | Fusion protein-pull down assay | Rat | 1-414 | E. coli | Human | Full-length | In vitro translation | 15066994
TRPV1 |  | Synaptotagmin 1 | Fusion protein-pull down assay | Rat | 1-414 | E. coli | Human | Full-length | In vitro translation | 15066994
TRPV1 |  | Synaptotagmin 4 | Fusion protein-pull down assay | Rat | 1-414 | E. coli | Human | Full-length | In vitro translation | 15066994

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | 80K-H | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 19801576
TRPV1 |  | AKAP5/AKAP150 | Co-immunofluorescence staining | Rat trigeminal ganglia neuron |  |  |  |  |  | 18381233
TRPV1 |  | AKAP5/AKAP150 | Co-immunofluorescence staining | Mouse dorsal root ganglion tissue |  |  |  |  |  | 18463244
TRPV1 |  | AKAP5/AKAP150 | Co-immunofluorescence staining | Rat dorsal root ganglion neuron |  |  |  |  |  | 18701070
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Rat trigeminal ganglia neuron |  |  |  |  |  | 22789851
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Rat trigeminal ganglia neuron |  |  |  |  |  | 18381233
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | CHO | Rat | Full-length | Rat | Full-length | 18381233
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Mouse spinalcord tissue |  |  |  |  |  | 18463244
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Mouse dorsal root ganglion tissue |  |  |  |  |  | 18463244
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 23264624
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Mouse | Full-length | 23264624
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Rat dorsal root ganglion neuron |  |  |  |  |  | 18701070
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 18701070
TRPV1 |  | Akt | Co-immunoprecipitation | Bovine aortic endothelial cells |  |  |  |  |  | 21493704
TRPV1 |  | AMPKơ2 | Co-immunoprecipitation | Bovine aortic endothelial cells |  |  |  |  |  | 22451268
TRPV1 |  | BKca | Co-immunofluorescence staining |  | HEK293 | Mouse | Full-length | Human | Full-length | 24147119
TRPV1 |  | BKca | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 24147119
TRPV1 |  | BKca | Co-immunoprecipitation | Rat dorsal root ganglion neuron |  |  |  |  |  | 24147119
TRPV1 |  | Calmodulin | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Rat | Full-length | 12808128
TRPV1 |  | CaMKII | Co-immunoprecipitation | Bovine aortic endothelial cells |  |  |  |  |  | 21493704
TRPV1 |  | CB1 | Co-immunofluorescence staining | Mouse corneal epithelium section |  |  |  |  |  | 23142606
TRPV1 |  | CB1 | Co-immunofluorescence staining | Human corneal epithelial cells |  |  |  |  |  | 23142606
TRPV1 |  | CB1 | Co-immunoprecipitation | Human corneal epithelial cells |  |  |  |  |  | 23142606
TRPV1 |  | E-cadherin | Co-immunofluorescence staining | Rat SMG cell line (SMG-C6) |  |  |  |  |  | 23345400
TRPV1 |  | E-cadherin | Co-immunoprecipitation | Rat SMG cell line (SMG-C6) |  |  |  |  |  | 23345400
TRPV1 |  | Eferin/Rab11-FIP3 | Co-immunofluorescence staining |  | HEK293T | Rat | Full-length | Human | Full-length | 15883036
TRPV1 |  | Eferin/Rab11-FIP3 | Co-immunoprecipitation |  | HEK293T | Rat | Full-length | Human | Full-length | 15883036
TRPV1 |  | EGFR | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not used |  | 19155296
TRPV1 |  | EGFR | Co-immunoprecipitation | HaCaT |  |  |  |  |  | 19155296
TRPV1 |  | eNOS | Co-immunoprecipitation | Bovine aortic endothelial cells |  |  |  |  |  | 21493704
TRPV1 |  | eNOS | Co-immunoprecipitation | Bovine aortic endothelial cells |  |  |  |  |  | 22451268
TRPV1 |  | eNOS | Mammalian two-hybrid |  | Bovine aortic endothelial cells | Rat | Full-length | Human | Full-length | 22451268
TRPV1 |  | FAF1 | Co-immunofluorescence staining | Rat dorsal root ganglion cell |  |  |  |  |  | 16510717
TRPV1 |  | FAF1 | Co-immunoprecipitation | Rat dorsal root ganglion cell |  |  |  |  |  | 16510717
TRPV1 |  | FAF1 | Co-immunoprecipitation |  | HEK293T | Rat | Full-length | Rat | Full-length | 16510717
TRPV1 |  | GABARAP | Co-immunofluorescence staining | Neonatal rat dorsal root ganglion |  |  |  |  |  | 20179142
TRPV1 |  | GABARAP | Fluorescence resonance energy transfer |  | HEK293 | Rat | Full-length | Human | Full-length | 20179142
TRPV1 |  | Ƣ-arrestin 2 | Co-immunoprecipitation | Rat trigeminal ganglia sensory neuron |  |  |  |  |  | 22952227
TRPV1 |  | Ƣ-arrestin 2 | Co-immunoprecipitation | Rat trigeminal (TG) ganglia |  |  |  |  |  | 24695785
TRPV1 |  | Ƣ-arrestin 2 | Co-immunoprecipitation |  | CHO | Rat | Full-length | Bovine | Full-length | 23360390
TRPV1 |  | Ƣ-catenin | Co-immunofluorescence staining | Rat SMG cell line (SMG-C6) |  |  |  |  |  | 23345400
TRPV1 |  | Ƣ-catenin | Co-immunoprecipitation | Rat SMG cell line (SMG-C6) |  |  |  |  |  | 23345400
TRPV1 |  | Ƣ-tubulin-5 | Co-immunoprecipitation |  | Rat dorsal root ganglion derived cell line F11 | Rat | Full-length | Not used |  | 15569253
TRPV1 |  | KCNQ2 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 21844219
TRPV1 |  | KCNQ3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 21844219
TRPV1 |  | KIF13B | Co-immunoprecipitation |  | CHO (rTRPV1 stable cell) | Not used |  | Rat | 1-557 | 23077056
TRPV1 |  | KIF13B | Co-immunoprecipitation |  | F11 | Rat | Full-length | Rat | 1-557 | 23077056
TRPV1 |  | KvƢ2 | Co-immunofluorescence staining | Mouse dorsal root ganglion neuron |  |  |  |  |  | 24036102
TRPV1 |  | KvƢ2 | Co-immunofluorescence staining |  | HEK293 tsA 201 | Mouse | Full-length | Not specified | Not specified | 24036102
TRPV1 |  | KvƢ2 | Co-immunoprecipitation |  | HEK293 tsA 201 | Mouse | Full-length | Not specified | Not specified | 24036102
TRPV1 |  | NMDAR1 | Co-immunofluorescence staining | Rat trigeminal ganglia lysates |  |  |  |  |  | 22609428
TRPV1 |  | NMDAR1 | Co-immunoprecipitation | Rat trigeminal ganglia lysates |  |  |  |  |  | 22609428
TRPV1 |  | NMDAR2B | Co-immunoprecipitation | Rat trigeminal ganglia lysates |  |  |  |  |  | 22609428
TRPV1 |  | ơ-tubulin-1B | Fluorescence resonance energy transfer |  | CHO | Mouse | Full-length | Human | Full-length | 22262838
TRPV1 |  | ơENaC | Co-immunofluorescence staining | Mouse M1-cortical collecting duct |  |  |  |  |  | 24890824
TRPV1 |  | ơENaC | Co-immunoprecipitation | Mouse M1-cortical collecting duct |  |  |  |  |  | 24890824
TRPV1 |  | OS-9 | Co-immunoprecipitation |  | HEK293T | Mouse | Full-length | Mouse | Full-length | 17932042
TRPV1 |  | P2RX3 | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Human | Full-length | 19223122
TRPV1 |  | PACS-1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 23159249
TRPV1 |  | PI3K-p85Ƣ | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Not used |  | 17074976
TRPV1 |  | PI3K-p85Ƣ | Co-immunoprecipitation | Mouse dorsal root ganglion cell |  |  |  |  |  | 17074976
TRPV1 |  | PIRT | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Mouse | Full-length | 18455988
TRPV1 |  | PKARIIơ | Co-immunoprecipitation | Mouse spinalcord tissue |  |  |  |  |  | 18463244
TRPV1 |  | PKCƢ | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Human | Full-length | 24920628
TRPV1 |  | PKCƢ | Co-immunofluorescence staining | Rat dorsal root ganglion cell |  |  |  |  |  | 24920628
TRPV1 |  | PKCƢ | Co-immunoprecipitation | Rat dorsal root ganglion cell |  |  |  |  |  | 24920628
TRPV1 |  | PKCƢ | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 24920628
TRPV1 |  | PPARơ | Co-immunoprecipitation |  | CHO | Rat | Full-length | Rat | Full-length | 25014183
TRPV1 |  | PRKD1/PKCƬ | Co-immunofluorescence staining | Rat dorsal root ganglion section |  |  |  |  |  | 18063480
TRPV1 |  | PRKD1/PKCƬ | Co-immunoprecipitation | Rat dorsal root ganglion lysates |  |  |  |  |  | 18063480
TRPV1 |  | PRKD1/PKCƬ | Co-immunoprecipitation |  | CHO | Rat | Full-length | Human | Full-length | 15471852
TRPV1 |  | PRKD1/PKCƬ | Co-immunoprecipitation | Rat dorsal root ganglion neuron |  |  |  |  |  | 15471852
TRPV1 |  | SNAPIN | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 15066994
TRPV1 |  | SRC | Co-immunoprecipitation | Rat dorsal root ganglion neuron |  |  |  |  |  | 15084474
TRPV1 |  | SRC | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 16319926
TRPV1 |  | Synaptotagmin 1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 15066994
TRPV1 |  | Synaptotagmin 4 | Co-immunofluorescence staining | Rat dorsal root ganglion neuron |  |  |  |  |  | 15066994
TRPV1 |  | Synaptotagmin 4 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 15066994
TRPV1 |  | TAK1 | Co-immunoprecipitation | Human corneal epithelial cells |  |  |  |  |  | 23142606
TRPV1 |  | TrkA | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Rat | Full-length | 11418861
TRPV1 |  | TRPA1 | Co-immunoprecipitation |  | CHO | Rat | Full-length | Mouse | Full-length | 20231274
TRPV1 |  | TRPA1 | Co-immunoprecipitation | Mouse trigeminal ganglia lysates |  |  |  |  |  | 20231274
TRPV1 |  | TRPV2 | Co-immunofluorescence staining | Rat dorsal root ganglion tissue |  |  |  |  |  | 16115206
TRPV1 |  | TRPV2 | Co-immunofluorescence staining |  | HEK293 | Rat | Full-length | Rat | Full-length | 16237318
TRPV1 |  | TRPV2 | Co-immunofluorescence staining | Rat dorsal root ganglion section |  |  |  |  |  | 16237318
TRPV1 |  | TRPV2 | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Rat | Full-length | 16115206
TRPV1 |  | TRPV2 | Co-immunoprecipitation | Rat brain cortical lysates |  |  |  |  |  | 16115206
TRPV1 |  | TRPV2 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 16237318
TRPV1 |  | TRPV2 | Co-immunoprecipitation |  | Rat dorsal root ganglion derived cell line F11 | Rat | Full-length | Rat | Full-length | 16237318
TRPV1 |  | TRPV2 | Co-immunoprecipitation | Rat dorsal root ganglion lysates |  |  |  |  |  | 16237318
TRPV1 |  | TRPV2 | Co-immunoprecipitation | Rat spinal cord lysates |  |  |  |  |  | 16237318
TRPV1 |  | TRPV2 | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Mouse | Full-length | 15713749
TRPV1 |  | TRPV3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 12077606
TRPV1 |  | Tubulin | Co-immunofluorescence staining | Rat supraoptic nucleus lysates |  |  |  |  |  | 25123313
TRPV1 |  | Tubulin | Co-immunoprecipitation | Rat supraoptic nucleus lysates |  |  |  |  |  | 25123313

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Human | Not determined | Human | 326-336 |  |  | 23699529
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation | Human | 736-749 | Human | Not determined |  |  | 18701070
TRPV1 |  | AKAP5/AKAP150 | Fluorescence resonance energy transfer | Human | Not determined | Human | 326-336 |  |  | 23699529
TRPV1 |  | AKAP5/AKAP150 | Fusion protein-pull down assay | Human | 736-749 | Human | Not determined |  |  | 18701070
TRPV1 |  | AKAP5/AKAP150 | Patch clamp | Human | 738 ?745 | Human | Not determined |  |  | 23616546
TRPV1 |  | Calmodulin | Fast performance liquid chromatography | Rat | 712?838 | Mouse | Not determined |  |  | 23119017
TRPV1 |  | Calmodulin | Fusion protein-pull down assay | Rat | 767-801 | Bovine | Not determined |  |  | 12808128
TRPV1 |  | Calmodulin | Fusion protein-pull down assay | Human | 101-364 | Not specified | Not determined |  |  | 19864432
TRPV1 |  | Calmodulin | Fusion protein-pull down assay | Rat | 189-222 | Not specified | Not determined |  |  | 14699077
TRPV1 |  | Calmodulin | Fusion protein-pull down assay | Rat | ARD domain | Not specified | Not determined |  |  | 20926660
TRPV1 |  | Calmodulin | X-ray diffraction-structural analysis | Rat | 784-798 | Human | 11-145 |  |  | 23109716
TRPV1 |  | Eferin/Rab11-FIP3 | Yeast two-hybrid | Rat | 684-820 | Mouse | 345-444 |  |  | 15883036
TRPV1 |  | FAF1 | Fusion protein-pull down assay | Rat | 243-440 | Rat | 110-169 |  |  | 16510717
TRPV1 |  | GABARAP | Fusion protein-pull down assay | Rat | 1-414 | Human | 1-36 |  |  | 20179142
TRPV1 |  | Ƣ-tubulin-3 | Fusion protein-pull down assay | Rat | 681-730 | Pig | Not determined |  |  | 17298389
TRPV1 |  | KCNQ2 | Co-immunoprecipitation | Human | Not determined | Human | 97-318 |  |  | 21844219
TRPV1 |  | KCNQ2 | Co-immunoprecipitation | Human | 1-684 | Human | Not determined |  |  | 21844219
TRPV1 |  | KIF13B | Cell surface biotinylation | Rat | Not determined | Rat | 455-557 |  |  | 23077056
TRPV1 |  | KIF13B | Co-immunoprecipitation | Rat | Not determined | Rat | 455-557 |  |  | 23077056
TRPV1 |  | PI3K-p85ơ | Fusion protein-pull down assay | Rat | N-terminus | Not specified | SH2 domain |  |  | 17074976
TRPV1 |  | PIRT | Co-immunoprecipitation | Rat | Not determined | Mouse | 110-135 |  |  | 18455988
TRPV1 |  | PKCƢ | Fusion protein-pull down assay | Human | 1-433 | Human | 341-673 |  |  | 24920628
TRPV1 |  | PLCƣ1 | Yeast two-hybrid | Rat | 761-835 | Rat | 861-920 |  |  | 15744307
TRPV1 |  | PRKD1/PKCƬ | Fusion protein-pull down assay | Rat | 99-118 | Human | Not determined |  |  | 15471852
TRPV1 |  | SRC | Fusion protein-pull down assay | Human | 1-433 | Rat | 83-144 |  |  | 16319926
TRPV1 |  | SRC | Fusion protein-pull down assay | Human | 681-839 | Rat | 83-144 |  |  | 16319926
TRPV1 |  | Synaptotagmin 4 | Fusion protein-pull down assay | Rat | 1-414 | Human | C2A domain |  |  | 15066994

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV1 |  | AKAP5/AKAP150 | Cell surface biotinylation |  | Increase in plasma membrane level |  | 18701070
TRPV1 |  | AKAP5/AKAP150 | Co-immunofluorescence staining |  | Increase in plasma membrane level |  | 23699529
TRPV1 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | Increase in plasma membrane level |  | 23616546
TRPV1 |  | AKAP5/AKAP150 | In vivo PTM assay | Phosphorylation |  |  | 18381233
TRPV1 |  | AKAP5/AKAP150 | Patch clamp |  |  | Activation | 18701070
TRPV1 |  | Calmodulin | Patch clamp |  |  | Inhibition | 14699077
TRPV1 |  | Calmodulin | Patch clamp |  |  | Sensitization | 23109716
TRPV1 |  | Calmodulin | Patch clamp |  |  | Inhibition | 12808128
TRPV1 |  | CB1 | Patch clamp |  |  | Inhibition | 23142606
TRPV1 |  | CDK5 | Cell surface biotinylation |  | Increase in plasma membrane level |  | 23077056
TRPV1 |  | CDK5 | In vitro PTM assay | Phosphorylation (Thr-407) |  |  | 17194758
TRPV1 |  | CDK5 | In vitro PTM assay | Phosphorylation |  |  | 22451679
TRPV1 |  | CDK5 | In vivo PTM assay | Phosphorylation (Thr-407) |  |  | 17194758
TRPV1 |  | FAF1 | Calcium measurement |  |  | Inhibition | 16510717
TRPV1 |  | FAF1 | Patch clamp |  |  | Inhibition | 16510717
TRPV1 |  | GABARAP | Calcium measurement |  |  | Inhibition | 20179142
TRPV1 |  | GABARAP | Cell surface biotinylation |  | Increase in plasma membrane level |  | 20179142
TRPV1 |  | GABARAP | Patch clamp |  |  | Inhibition | 20179142
TRPV1 |  | Ƣ-arrestin 2 | Calcium measurement |  |  | Desensitization | 22952227
TRPV1 |  | Ƣ-arrestin 2 | In vivo PTM assay | Dephosphorylation |  |  | 22952227
TRPV1 |  | KIF13B | Cell surface biotinylation |  | Increase in plasma membrane level |  | 23077056
TRPV1 |  | KvƢ2 | Cell surface biotinylation |  | Increase in plasma membrane level |  | 24036102
TRPV1 |  | PIRT | Patch clamp |  |  | Activation | 18455988
TRPV1 |  | PKA | In vitro PTM assay | Phosphorylation (Ser-116) |  |  | 12194871
TRPV1 |  | PKA | Patch clamp |  |  | Activation | 12194871
TRPV1 |  | PKC | In vitro PTM assay | Phosphorylation |  |  | 14523239
TRPV1 |  | PKCƢ | In vivo PTM assay | Phosphorylation (Thr-705) |  |  | 24920628
TRPV1 |  | PKCƢ | Patch clamp |  |  | Activation | 24920628
TRPV1 |  | PKCƥ | In vitro PTM assay | Phosphorylation (Ser-800) |  |  | 11884385
TRPV1 |  | PKCƥ | In vivo PTM assay | Phosphorylation (Ser-502) |  |  | 11884385
TRPV1 |  | PKCƥ | Patch clamp |  |  | Activation | 11884385
TRPV1 |  | PPARơ | Calcium measurement |  |  | Activation | 25014183
TRPV1 |  | PPARơ | Patch clamp |  |  | Activation | 25014183
TRPV1 |  | PRKD1/PKCƬ | Calcium measurement |  |  | Activation | 15471852
TRPV1 |  | PRKD1/PKCƬ | In vitro PTM assay | Phosphorylation (Ser-116) |  |  | 15471852
TRPV1 |  | SRC | Calcium measurement |  |  | Activation | 16319926
TRPV1 |  | SRC | In vitro PTM assay | Phosphorylayion (Tyr-200) |  |  | 16319926
TRPV1 |  | SRC | In vivo PTM assay | Phosphorylation |  |  | 15084474
TRPV1 |  | SRC | In vivo PTM assay | Phosphorylayion (Tyr-200) |  |  | 16319926
TRPV1 |  | SRC | Patch clamp |  |  | Activation | 15084474
TRPV1 |  | SRC | Patch clamp |  |  | Activation | 16319926
TRPV1 |  | TrkA | In vivo PTM assay | Phosphorylayion (Tyr-200) |  |  | 16319926
TRPV1 |  | TrkA | Patch clamp |  |  | Activation | 16319926

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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