# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# FAF1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (8)
- Disease (0)

Name: FAS-associated factor 1 (FAF1)
Official Symbol: FAF1 provided by HGNC
Function:
Potentiates but cannot initiate FAS-induced apoptosis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 11124 | Q9UNN5 | DIP-38245N | Q9UNN5 | MINT-88745 | 116298 | Q9UNN5 |  | hsa:11124 | 604460
Mouse | 14084 | P54731 | DIP-41606N |  | MINT-1513304 | 199588 | P54731 |  | mmu:14084 |
Rat | 140657 | Q924K2 |  |  | UNK-5532353 | 250821 | Q924K2 |  | rno:140657 |

PPI pairs:

TRPV1

Biological Process:

- GO:0006915 : apoptotic process
- GO:0008219 : cell death
- GO:0007253 : cytoplasmic sequestering of NF-kappaB
- GO:0043065 : positive regulation of apoptotic process
- GO:0031334 : positive regulation of protein complex assembly
- GO:0043161 : proteasomal ubiquitin-dependent protein catabolic process
- GO:0030155 : regulation of cell adhesion
- GO:0042176 : regulation of protein catabolic process

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | FAF1 | Yeast two-hybrid | Rat | 243-440 | Rat | Sensory neuron | cDNA expression library |  | 16510717

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPV1 |  | FAF1 | Fusion protein-pull down assay | Rat | 1-440 | E. coli | Rat | Full-length | E. coli | 16510717

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | FAF1 | Co-immunofluorescence staining | Rat dorsal root ganglion cell |  |  |  |  |  | 16510717
TRPV1 |  | FAF1 | Co-immunoprecipitation | Rat dorsal root ganglion cell |  |  |  |  |  | 16510717
TRPV1 |  | FAF1 | Co-immunoprecipitation |  | HEK293T | Rat | Full-length | Rat | Full-length | 16510717

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | FAF1 | Fusion protein-pull down assay | Rat | 243-440 | Rat | 110-169 |  |  | 16510717

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV1 |  | FAF1 | Calcium measurement |  |  | Inhibition | 16510717
TRPV1 |  | FAF1 | Patch clamp |  |  | Inhibition | 16510717

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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