# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# BMPR-2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (26)
- Disease (3)

Name: Bone morphogenetic protein receptor type-2 (BMPR-2)
Official Symbol: BMPR2 provided by HGNC
Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 659 | Q13873 | DIP-5794N DIP-5941N DIP-5942N | Q13873 | MINT-124272 | 107127 | Q13873 |  | hsa:659 | 600799
Mouse | 12168 | O35607 | DIP-33908N | O35607 | MINT-1743993 | 198373 | O35607 |  | mmu:12168 |
Rat | 140590 |  |  |  |  | 250804 |  |  | rno:140590 |

PPI pairs:

TRPC1

Biological Process:

- GO:0009952 : anterior/posterior pattern specification
- GO:0060840 : artery development
- GO:0001974 : blood vessel remodeling
- GO:0030509 : BMP signaling pathway
- GO:0007420 : brain development
- GO:0009267 : cellular response to starvation
- GO:0048286 : lung alveolus development
- GO:0001946 : lymphangiogenesis
- GO:0060836 : lymphatic endothelial cell differentiation
- GO:0001707 : mesoderm formation
- GO:0030308 : negative regulation of cell growth
- GO:2000279 : negative regulation of DNA biosynthetic process
- GO:0003085 : negative regulation of systemic arterial blood pressure
- GO:0045906 : negative regulation of vasoconstriction
- GO:0030513 : positive regulation of BMP signaling pathway
- GO:0030501 : positive regulation of bone mineralization
- GO:0010595 : positive regulation of endothelial cell migration
- GO:0001938 : positive regulation of endothelial cell proliferation
- GO:0010634 : positive regulation of epithelial cell migration
- GO:0045669 : positive regulation of osteoblast differentiation
- GO:0010862 : positive regulation of pathway-restricted SMAD protein phosphorylation
- GO:0014916 : regulation of lung blood pressure
- GO:0061298 : retina vasculature development in camera-type eye
- GO:0006366 : transcription from RNA polymerase II promoter
- GO:0048010 : vascular endothelial growth factor receptor signaling pathway
- GO:0060841 : venous blood vessel development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:600799 : Pulmonary hypertension, familial primary (OMIM:178600 )
- OMIM:600799 : Pulmonary venoocclusive disease (OMIM:265450 )
- OMIM:600799 : Pulmonary hypertension, primary, fenfluramine-associated (OMIM:178600 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | BMPR-2 | Affinity purification-mass spectrometry | Not used as a bait |  | Mouse | Leg muscle | C2C12 lysates |  | 15188402

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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