# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# FKBP12 / TRP channels

- Basic Information
- External Database
- PPI pairs (3)
- Biological Process (17)
- Disease (0)

Name: Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP12)
Official Symbol: FKBP1A provided by HGNC
Function:
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 2280 | P62942 | DIP-29710N | P62942 | MINT-87893 | 108570 | P62942 |  | hsa:2280 | 186945
Mouse | 14225 | P26883 | DIP-29707N |  | MINT-4095099 | 199682 | P26883 |  | mmu:14225 |
Rat | 25639 | Q62658 |  |  | MINT-4565116 | 247668 | Q62658 |  | rno:25639 |

PPI pairs:

TRPC3 | TRPC6 | TRPC7

Biological Process:

- GO:0006458 : 'de novo' protein folding
- GO:0034205 : beta-amyloid formation
- GO:0043206 : extracellular fibril organization
- GO:0060347 : heart trabecula formation
- GO:0032513 : negative regulation of protein phosphatase type 2B activity
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0032092 : positive regulation of protein binding
- GO:0031398 : positive regulation of protein ubiquitination
- GO:0022417 : protein maturation by protein folding
- GO:0042026 : protein refolding
- GO:0032925 : regulation of activin receptor signaling pathway
- GO:0050776 : regulation of immune response
- GO:0060314 : regulation of ryanodine-sensitive calcium-release channel activity
- GO:0007183 : SMAD protein complex assembly
- GO:0042110 : T cell activation
- GO:0007179 : transforming growth factor beta receptor signaling pathway
- GO:0055010 : ventricular cardiac muscle tissue morphogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | FKBP12 | Inference |  |  |  |  |  | Prediction | 15199065
TRPC6 |  | FKBP12 | Inference |  |  |  |  |  | Prediction | 15994335
TRPC7 |  | FKBP12 | Inference |  |  |  |  |  | Prediction | 15199065

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPC3 |  | FKBP12 | Co-immunoprecipitation | Human | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065
TRPC6 |  | FKBP12 | Co-immunoprecipitation | Mouse | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065
TRPC7 |  | FKBP12 | Co-immunoprecipitation | Mouse | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | FKBP12 | Co-immunoprecipitation | Rat cerebral cortex |  |  |  |  |  | 15199065
TRPC6 |  | FKBP12 | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335
TRPC6 |  | FKBP12 | Co-immunoprecipitation | Rat cerebral cortex |  |  |  |  |  | 15199065
TRPC7 |  | FKBP12 | Co-immunoprecipitation | Rat cerebral cortex |  |  |  |  |  | 15199065

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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