# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# RhoA / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (30)
- Disease (0)

Name: Transforming protein RhoA (RhoA)
Official Symbol: RHOA provided by HGNC
Function:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 387 | P61586 | DIP-29642N | P61586 | MINT-4999683 | 106880 | P61586 |  | hsa:387 | 165390
Mouse | 11848 | Q9QUI0 | DIP-29984N | Q9QUI0 | MINT-118662 | 198192 | Q9QUI0 |  | mmu:11848 |
Rat | 117273 | P61589 | DIP-37248N | P61589 | MINT-4542785 | 250720 | P61589 |  | rno:117273 |

PPI pairs:

TRPC1

Biological Process:

- GO:0030036 : actin cytoskeleton organization
- GO:0030521 : androgen receptor signaling pathway
- GO:0043297 : apical junction assembly
- GO:0007411 : axon guidance
- GO:0007160 : cell-matrix adhesion
- GO:0036089 : cleavage furrow formation
- GO:0050771 : negative regulation of axonogenesis
- GO:0033144 : negative regulation of intracellular steroid hormone receptor signaling pathway
- GO:0043524 : negative regulation of neuron apoptotic process
- GO:0048011 : nerve growth factor receptor signaling pathway
- GO:0043931 : ossification involved in bone maturation
- GO:0048015 : phosphatidylinositol-mediated signaling
- GO:0030168 : platelet activation
- GO:0050772 : positive regulation of axonogenesis
- GO:0071777 : positive regulation of cell cycle cytokinesis
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0045666 : positive regulation of neuron differentiation
- GO:0042346 : positive regulation of NF-kappaB import into nucleus
- GO:0051496 : positive regulation of stress fiber assembly
- GO:0030334 : regulation of cell migration
- GO:0033688 : regulation of osteoblast proliferation
- GO:0051056 : regulation of small GTPase mediated signal transduction
- GO:0006357 : regulation of transcription from RNA polymerase II promoter
- GO:0007266 : Rho protein signal transduction
- GO:0007519 : skeletal muscle tissue development
- GO:0090307 : spindle assembly involved in mitosis
- GO:0043149 : stress fiber assembly
- GO:0061383 : trabecula morphogenesis
- GO:0007179 : transforming growth factor beta receptor signaling pathway
- GO:0019048 : virus-host interaction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | RhoA | Inference |  |  |  |  |  | Prediction | 12766172

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | RhoA | Co-immunofluorescence staining |  | Human pulmonary arterial endothelial cell | Not used |  | Not specified | Full-length | 12766172
TRPC1 |  | RhoA | Co-immunoprecipitation | Human pulmonary arterial endothelial cell |  |  |  |  |  | 12766172

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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