# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Calcineurin / TRP channels

- Basic Information
- External Database
- PPI pairs (2)
- Biological Process (17)
- Disease (0)

Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Calcineurin)
Official Symbol: PPP3CA provided by HGNC
Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5530 | Q08209 | DIP-29315N DIP-6095N | Q08209 | MINT-1037516 | 111522 | Q08209 |  | hsa:5530 | 114105
Mouse | 19055 | P63328 | DIP-31543N | P63328 | MINT-135995 | 202344 | P63328 |  | mmu:19055 |
Rat | 24674 | P63329 |  |  | MINT-4106043 | 246806 | P63329 |  | rno:24674 |

PPI pairs:

TRPC1 | TRPC6

Biological Process:

- GO:0033173 : calcineurin-NFAT signaling cascade
- GO:0006816 : calcium ion transport
- GO:0035690 : cellular response to drug
- GO:0071333 : cellular response to glucose stimulus
- GO:0000082 : G1/S transition of mitotic cell cycle
- GO:0046676 : negative regulation of insulin secretion
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0006470 : protein dephosphorylation
- GO:0006606 : protein import into nucleus
- GO:0060079 : regulation of excitatory postsynaptic membrane potential
- GO:0050804 : regulation of synaptic transmission
- GO:0001975 : response to amphetamine
- GO:0051592 : response to calcium ion
- GO:0006950 : response to stress
- GO:0048741 : skeletal muscle fiber development
- GO:0042110 : T cell activation
- GO:0014883 : transition between fast and slow fiber

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | Calcineurin | Inference |  |  |  |  |  | Prediction | 23228564
TRPC6 |  | Calcineurin | Inference |  |  |  |  |  | Prediction | 15994335

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | Calcineurin | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 23228564
TRPC6 |  | Calcineurin | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPC6 |  | Calcineurin | In vivo PTM assay | Dephosphorylation |  |  | 24740790

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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