# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# VAMPB / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (8)
- Disease (2)

Name: Vesicle-associated membrane protein-associated protein B/C (VAMPB)
Official Symbol: VAPB provided by HGNC
Function:
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 9217 | O95292 | DIP-39816N | O95292 | MINT-3002838 | 114650 | O95292 |  | hsa:9217 | 605704
Mouse | 56491 | Q9QY76 | DIP-32207N | Q9QY76 |  | 208016 | Q9QY76 |  | mmu:56491 |
Rat | 60431 | Q9Z269 | DIP-57372N |  | MINT-4566897 | 248831 | Q9Z269 |  | rno:60431 |

PPI pairs:

TRPP1

Biological Process:

- GO:0006987 : activation of signaling protein activity involved in unfolded protein response
- GO:0008219 : cell death
- GO:0006874 : cellular calcium ion homeostasis
- GO:0006644 : phospholipid metabolic process
- GO:0045070 : positive regulation of viral genome replication
- GO:0044281 : small molecule metabolic process
- GO:0030148 : sphingolipid biosynthetic process
- GO:0019048 : virus-host interaction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:605704 : Amyotrophic lateral sclerosis 8 (OMIM:608627 )
- OMIM:605704 : Spinal muscular atrophy, late-onset, Finkel type (OMIM:182980 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | VAMPB | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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