# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# NDKA / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (19)
- Disease (1)

Name: Nucleoside diphosphate kinase A (NDKA)
Official Symbol: NME1 provided by HGNC
Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4830 | P15531 | DIP-39164N | P15531 | MINT-221462 | 110894 | P15531 |  | hsa:4830 | 156490
Mouse | 18102 | P15532 | DIP-34130N | P15532 | MINT-1868955 | 201788 | P15532 |  | mmu:18102 |
Rat | 191575 | Q05982 | DIP-37833N | Q05982 |  | 251322 | Q05982 |  | rno:191575 |

PPI pairs:

TRPML1

Biological Process:

- GO:0035690 : cellular response to drug
- GO:0071398 : cellular response to fatty acid
- GO:0071333 : cellular response to glucose stimulus
- GO:0006241 : CTP biosynthetic process
- GO:0006897 : endocytosis
- GO:0006183 : GTP biosynthetic process
- GO:0021766 : hippocampus development
- GO:0008285 : negative regulation of cell proliferation
- GO:0010629 : negative regulation of gene expression
- GO:0002762 : negative regulation of myeloid leukocyte differentiation
- GO:0015949 : nucleobase-containing small molecule interconversion
- GO:0043388 : positive regulation of DNA binding
- GO:0050679 : positive regulation of epithelial cell proliferation
- GO:0010976 : positive regulation of neuron projection development
- GO:0042981 : regulation of apoptotic process
- GO:0014075 : response to amine
- GO:0051591 : response to cAMP
- GO:0033574 : response to testosterone
- GO:0006228 : UTP biosynthetic process

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:156490 : Neuroblastoma (OMIM:256700 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPML1 |  | NDKA | Affinity purification-mass spectrometry | Mouse | Full-length | Mouse | RAW264.7 macrophages | Lysates |  | 23418601

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPML1 |  | NDKA | Split-Ubiquitin Yeast two-hybrid | Mouse | Full-length | Yeast | Mouse | Full-length | Yeast | 23418601

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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