# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# CB1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (29)
- Disease (0)

Name: Cannabinoid receptor 1 (CB1)
Official Symbol: CNR1 provided by HGNC
Function:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 1268 | P21554 |  | P21554 | MINT-7268382 | 107668 | P21554 |  | hsa:1268 | 114610
Mouse | 12801 | P47746 |  |  |  | 198793 | P47746 |  | mmu:12801 |
Rat | 25248 | P20272 |  | P20272 | MINT-7266592 | 247288 | P20272 |  | rno:25248 |

PPI pairs:

TRPV1

Biological Process:

- GO:0007188 : adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- GO:0007568 : aging
- GO:0007610 : behavior
- GO:0060135 : maternal process involved in female pregnancy
- GO:0007613 : memory
- GO:0045759 : negative regulation of action potential
- GO:0045776 : negative regulation of blood pressure
- GO:0033602 : negative regulation of dopamine secretion
- GO:0031999 : negative regulation of fatty acid beta-oxidation
- GO:0033004 : negative regulation of mast cell activation
- GO:0051001 : negative regulation of nitric-oxide synthase activity
- GO:0002866 : positive regulation of acute inflammatory response to antigenic stimulus
- GO:0043065 : positive regulation of apoptotic process
- GO:0045777 : positive regulation of blood pressure
- GO:0031622 : positive regulation of fever generation
- GO:0010976 : positive regulation of neuron projection development
- GO:0060259 : regulation of feeding behavior
- GO:0050796 : regulation of insulin secretion
- GO:0060405 : regulation of penile erection
- GO:0032228 : regulation of synaptic transmission, GABAergic
- GO:0051966 : regulation of synaptic transmission, glutamatergic
- GO:0042220 : response to cocaine
- GO:0045471 : response to ethanol
- GO:0032496 : response to lipopolysaccharide
- GO:0043278 : response to morphine
- GO:0035094 : response to nicotine
- GO:0007584 : response to nutrient
- GO:0019233 : sensory perception of pain
- GO:0007283 : spermatogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | CB1 | Inference |  |  |  |  |  | Prediction | 23142606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | CB1 | Co-immunofluorescence staining | Mouse corneal epithelium section |  |  |  |  |  | 23142606
TRPV1 |  | CB1 | Co-immunofluorescence staining | Human corneal epithelial cells |  |  |  |  |  | 23142606
TRPV1 |  | CB1 | Co-immunoprecipitation | Human corneal epithelial cells |  |  |  |  |  | 23142606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV1 |  | CB1 | Patch clamp |  |  | Inhibition | 23142606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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