# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Caveolin-3 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (28)
- Disease (6)

Name: Caveolin-3 (Caveolin-3)
Official Symbol: CAV3 provided by HGNC
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 859 | P56539 |  | P56539 | MINT-3021471 | 107307 | P56539 |  | hsa:859 | 601253
Mouse | 12391 | P51637 | DIP-31069N | P51637 | MINT-2982959 | 198516 | P51637 |  | mmu:12391 |
Rat | 29161 | P51638 | DIP-40859N |  | MINT-145738 | 247843 | P51638 |  | rno:29161 |

PPI pairs:

TRPC1

Biological Process:

- GO:0070836 : caveola assembly
- GO:0016049 : cell growth
- GO:0042632 : cholesterol homeostasis
- GO:0007204 : elevation of cytosolic calcium ion concentration
- GO:0042593 : glucose homeostasis
- GO:0046716 : muscle cell homeostasis
- GO:0007517 : muscle organ development
- GO:0051926 : negative regulation of calcium ion transport
- GO:0010614 : negative regulation of cardiac muscle hypertrophy
- GO:0045792 : negative regulation of cell size
- GO:0043407 : negative regulation of MAP kinase activity
- GO:0051001 : negative regulation of nitric-oxide synthase activity
- GO:0060299 : negative regulation of sarcomere organization
- GO:0031116 : positive regulation of microtubule polymerization
- GO:0072659 : protein localization to plasma membrane
- GO:0090279 : regulation of calcium ion import
- GO:1901019 : regulation of calcium ion transmembrane transporter activity
- GO:0055117 : regulation of cardiac muscle contraction
- GO:0002027 : regulation of heart rate
- GO:1900825 : regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential
- GO:0051394 : regulation of nerve growth factor receptor activity
- GO:0038009 : regulation of signal transduction by receptor internalization
- GO:0014819 : regulation of skeletal muscle contraction
- GO:2000649 : regulation of sodium ion transmembrane transporter activity
- GO:0060373 : regulation of ventricular cardiac muscle cell membrane depolarization
- GO:0060307 : regulation of ventricular cardiac muscle cell membrane repolarization
- GO:0033292 : T-tubule organization
- GO:0006641 : triglyceride metabolic process

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:601253 : Muscular dystrophy, limb-girdle, type IC (OMIM:607801 )
- OMIM:601253 : Rippling muscle disease (OMIM:606072 )
- OMIM:601253 : Creatine phosphokinase, elevated serum (OMIM:123320 )
- OMIM:601253 : Myopathy, distal, Tateyama type (OMIM:614321 )
- OMIM:601253 : Cardiomyopathy, familial hypertrophic (OMIM:192600 )
- OMIM:601253 : Long QT syndrome-9 (OMIM:611818 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | Caveolin-3 | Inference |  |  |  |  |  | Prediction | 18544631

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | Caveolin-3 | Co-immunofluorescence staining | Mouse skeletal muscle section |  |  |  |  |  | 18544631
TRPC1 |  | Caveolin-3 | Co-immunoprecipitation | Mouse skeletal muscle cell |  |  |  |  |  | 18544631
TRPC1 |  | Caveolin-3 | Fluorescence resonance energy transfer |  | Mouse skeletal muscle | Human | Full-length | Mouse | Full-length | 18544631

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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