# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# DRP-2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (13)
- Disease (0)

Name: Dihydropyrimidinase-related protein 2 (DRP-2)
Official Symbol: DPYSL2 provided by HGNC
Function:
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 1808 | Q16555 |  | Q16555 | MINT-3032752 | 108142 | Q16555 |  | hsa:1808 | 602463
Mouse | 12934 | O08553 |  | O08553 |  | 198891 | O08553 |  | mmu:12934 |
Rat | 25416 | P47942 |  | P47942 | MINT-224453 | 247451 | P47942 |  | rno:25416 |

PPI pairs:

TRPC3

Biological Process:

- GO:0007411 : axon guidance
- GO:0007010 : cytoskeleton organization
- GO:0006139 : nucleobase-containing compound metabolic process
- GO:0021772 : olfactory bulb development
- GO:0014049 : positive regulation of glutamate secretion
- GO:0006208 : pyrimidine nucleobase catabolic process
- GO:0045664 : regulation of neuron differentiation
- GO:0001975 : response to amphetamine
- GO:0042220 : response to cocaine
- GO:0042493 : response to drug
- GO:0007165 : signal transduction
- GO:0021510 : spinal cord development
- GO:0048489 : synaptic vesicle transport

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | DRP-2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | DRP-2 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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