# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# PERK / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (22)
- Disease (1)

Name: Eukaryotic translation initiation factor 2-alpha kinase 3 (PERK)
Official Symbol: EIF2AK3 provided by HGNC
Function:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 9451 | Q9NZJ5 | DIP-34584N | Q9NZJ5 |  | 114840 | Q9NZJ5 |  | hsa:9451 | 604032
Mouse | 13666 | Q9Z2B5 | DIP-39494N | Q9Z2B5 |  | 199413 | Q9Z2B5 |  | mmu:13666 |
Rat | 29702 | Q9Z1Z1 |  |  |  | 248320 | Q9Z1Z1 |  | rno:29702 |

PPI pairs:

TRPP1

Biological Process:

- GO:0006919 : activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0006987 : activation of signaling protein activity involved in unfolded protein response
- GO:0030282 : bone mineralization
- GO:0019722 : calcium-mediated signaling
- GO:0002063 : chondrocyte development
- GO:0031018 : endocrine pancreas development
- GO:0007029 : endoplasmic reticulum organization
- GO:0006983 : ER overload response
- GO:0045444 : fat cell differentiation
- GO:0030073 : insulin secretion
- GO:0048009 : insulin-like growth factor receptor signaling pathway
- GO:0007595 : lactation
- GO:0031642 : negative regulation of myelination
- GO:0032057 : negative regulation of translational initiation in response to stress
- GO:0032092 : positive regulation of protein binding
- GO:0009967 : positive regulation of signal transduction
- GO:0046777 : protein autophosphorylation
- GO:0051260 : protein homooligomerization
- GO:0019217 : regulation of fatty acid metabolic process
- GO:0032933 : SREBP signaling pathway
- GO:0006412 : translation
- GO:0006926 : virus-infected cell apoptotic process

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:604032 : Wolcott-Rallison syndrome (OMIM:226980 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | PERK | Inference |  |  |  |  |  | Prediction | 18664456

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | PERK | Co-immunoprecipitation | Mouse Inner medullary collecting duct |  |  |  |  |  | 18664456
TRPP1 |  | PERK | Co-immunoprecipitation |  | HEK293T | Not used |  | Mouse | Full-length | 18664456
TRPP1 |  | PERK | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Not used |  | 18664456

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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