# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# RyR1 / TRP channels

- Basic Information
- External Database
- PPI pairs (4)
- Biological Process (8)
- Disease (4)

Name: Ryanodine receptor 1 (RyR1)
Official Symbol: RYR1 provided by HGNC
Function:
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 6261 | P21817 | DIP-29708N | P21817 | MINT-1605046 | 112173 | P21817 |  | hsa:6261 | 180901
Mouse | 20190 | Q80X16 | DIP-29705N | Q80X16 |  | 203045 | Q80X16 |  | mmu:20190 |
Rat | 114207 | F1LMY4 |  |  | MINT-195292 | 250309 |  |  | rno:114207 |

PPI pairs:

TRPC1 | TRPC5 | TRPV1 | TRPV6

Biological Process:

- GO:0071313 : cellular response to caffeine
- GO:0006936 : muscle contraction
- GO:0043931 : ossification involved in bone maturation
- GO:0003151 : outflow tract morphogenesis
- GO:0014808 : release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- GO:0001666 : response to hypoxia
- GO:0048741 : skeletal muscle fiber development
- GO:0043588 : skin development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:180901 : Malignant hyperthermia susceptibility 1 (OMIM:145600 )
- OMIM:180901 : Central core disease (OMIM:117000 )
- OMIM:180901 : Minicore myopathy with external ophthalmoplegia (OMIM:255320 )
- OMIM:180901 : Neuromuscular disease, congenital, with uniform type 1 fiber (OMIM:117000 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | RyR1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rabbit | Fast-twitch muscle | Triad vesicles |  | 18215135
TRPC5 |  | RyR1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rabbit | Fast-twitch muscle | Triad vesicles |  | 18215135
TRPV1 |  | RyR1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rabbit | Fast-twitch muscle | Triad vesicles |  | 18215135
TRPV6 |  | RyR1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rabbit | Fast-twitch muscle | Triad vesicles |  | 18215135

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | RyR1 | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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