# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TAP2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (9)
- Disease (2)

Name: Antigen peptide transporter 2 (TAP2)
Official Symbol: TAP2 provided by HGNC
Function:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 6891 | Q03519 | DIP-322N | Q03519 | MINT-2838244 | 112754 | Q03519 |  | hsa:6891 | 170261
Mouse | 21355 | P36371 |  |  | MINT-4136884 | 203967 | P36371 |  | mmu:21355 |
Rat | 24812 | P36372 |  |  | UNK-5377031 | 246934 | P36372 |  | rno:24812 |

PPI pairs:

TRPP1

Biological Process:

- GO:0002485 : antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
- GO:0002489 : antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
- GO:0002479 : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- GO:0002481 : antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
- GO:0046967 : cytosol to ER transport
- GO:0019060 : intracellular transport of viral proteins in host cell
- GO:0046968 : peptide antigen transport
- GO:0002591 : positive regulation of antigen processing and presentation of peptide antigen via MHC class I
- GO:0001916 : positive regulation of T cell mediated cytotoxicity

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:170261 : Bare lymphocyte syndrome, type I, due to TAP2 deficiency (OMIM:604571 )
- OMIM:170261 : Wegener-like granulomatosis (OMIM: )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | TAP2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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