# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TrkB / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (29)
- Disease (1)

Name: BDNF/NT-3 growth factors receptor (TrkB)
Official Symbol: NTRK2 provided by HGNC
Function:
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4915 | Q16620 | DIP-5720N | Q16620 | MINT-156841 | 110970 | Q16620 |  | hsa:4915 | 600456
Mouse | 18212 | P15209 | DIP-5722N | P15209 | MINT-240722 | 201869 | P15209 |  | mmu:18212 |
Rat | 25054 | Q63604 | DIP-5717N |  | MINT-1204365 | 247131 | Q63604 |  | rno:25054 |

PPI pairs:

TRPC3

Biological Process:

- GO:0007190 : activation of adenylate cyclase activity
- GO:0035584 : calcium-mediated signaling using intracellular calcium source
- GO:0021954 : central nervous system neuron development
- GO:0021987 : cerebral cortex development
- GO:0007631 : feeding behavior
- GO:0014047 : glutamate secretion
- GO:0007612 : learning
- GO:0060291 : long-term synaptic potentiation
- GO:0042490 : mechanoreceptor differentiation
- GO:2000811 : negative regulation of anoikis
- GO:0043524 : negative regulation of neuron apoptotic process
- GO:0048011 : nerve growth factor receptor signaling pathway
- GO:0001764 : neuron migration
- GO:0048709 : oligodendrocyte differentiation
- GO:0048935 : peripheral nervous system neuron development
- GO:0050772 : positive regulation of axonogenesis
- GO:0008284 : positive regulation of cell proliferation
- GO:0010628 : positive regulation of gene expression
- GO:0043410 : positive regulation of MAPK cascade
- GO:0010976 : positive regulation of neuron projection development
- GO:0014068 : positive regulation of phosphatidylinositol 3-kinase cascade
- GO:0051968 : positive regulation of synaptic transmission, glutamatergic
- GO:0046777 : protein autophosphorylation
- GO:0050773 : regulation of dendrite development
- GO:0046928 : regulation of neurotransmitter secretion
- GO:0051896 : regulation of protein kinase B signaling cascade
- GO:0032314 : regulation of Rac GTPase activity
- GO:0046548 : retinal rod cell development
- GO:0001570 : vasculogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:600456 : Obesity, hyperphagia, and developmental delay (OMIM:613886 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | TrkB | Inference |  |  |  |  |  | Prediction | 10677043

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | TrkB | Co-immunofluorescence staining | Rat brain pontine neuron |  |  |  |  |  | 10677043
TRPC3 |  | TrkB | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 10677043

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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