# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Pericentrin / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (13)
- Disease (1)

Name: Pericentrin (Pericentrin)
Official Symbol: PCNT provided by HGNC
Function:
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5116 | O95613 | DIP-33829N | O95613 | MINT-4527763 | 111146 | O95613 |  | hsa:5116 | 605925
Mouse | 18541 | P48725 | DIP-54639N | P48725 | MINT-4084690 | 202052 | P48725 |  | mmu:18541 |
Rat |  |  |  |  |  |  |  |  |  |

PPI pairs:

TRPP1

Biological Process:

- GO:0006915 : apoptotic process
- GO:0048854 : brain morphogenesis
- GO:0021696 : cerebellar cortex morphogenesis
- GO:0042384 : cilium assembly
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0001701 : in utero embryonic development
- GO:0035108 : limb morphogenesis
- GO:0000226 : microtubule cytoskeleton organization
- GO:0035264 : multicellular organism growth
- GO:0061351 : neural precursor cell proliferation
- GO:0001764 : neuron migration
- GO:0021772 : olfactory bulb development
- GO:0007051 : spindle organization

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:605925 : Microcephalic osteodysplastic primordial dwarfism, type II (OMIM:210720 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | Pericentrin | Inference |  |  |  |  |  | Prediction | 15337773

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | Pericentrin | Co-immunofluorescence staining | RPE1 |  |  |  |  |  | 15337773
TRPP1 |  | Pericentrin | Co-immunoprecipitation | RPE1 |  |  |  |  |  | 15337773

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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