# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# PSMD7 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (16)
- Disease (0)

Name: 26S proteasome non-ATPase regulatory subunit 7 (PSMD7)
Official Symbol: PSMD7 provided by HGNC
Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5713 | P51665 | DIP-27572N | P51665 | MINT-5002613 | 111685 | P51665 |  | hsa:5713 | 157970
Mouse | 17463 | P26516 | DIP-35175N | P26516 | MINT-4108972 | 201472 | P26516 |  | mmu:17463 |
Rat | 307821 | D4AEH3 | DIP-56041N | D4AEH3 |  | 258820 |  |  | rno:307821 |

PPI pairs:

TRPP1

Biological Process:

- GO:0031145 : anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- GO:0002479 : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- GO:0006915 : apoptotic process
- GO:0006977 : DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- GO:0000082 : G1/S transition of mitotic cell cycle
- GO:0010467 : gene expression
- GO:0000216 : M/G1 transition of mitotic cell cycle
- GO:0016071 : mRNA metabolic process
- GO:0051436 : negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- GO:0051437 : positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- GO:0000209 : protein polyubiquitination
- GO:0042981 : regulation of apoptotic process
- GO:0006521 : regulation of cellular amino acid metabolic process
- GO:0000084 : S phase of mitotic cell cycle
- GO:0044281 : small molecule metabolic process
- GO:0016032 : viral reproduction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | PSMD7 | Inference |  |  |  |  |  | Prediction | 18178578

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | PSMD7 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 18178578

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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