# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Myosin-HIIA / TRP channels

- Basic Information
- External Database
- PPI pairs (3)
- Biological Process (22)
- Disease (6)

Name: Myosin-9 (Myosin-HIIA)
Official Symbol: MYH9 provided by HGNC
Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4627 | P35579 | DIP-33103N | P35579 | MINT-1147379 | 110712 | P35579 |  | hsa:4627 | 160775
Mouse | 17886 | Q8VDD5 | DIP-29546N | Q8VDD5 | MINT-2524850 | 201650 | Q8VDD5 |  | mmu:17886 |
Rat | 25745 | Q62812 | DIP-43726N | Q62812 | MINT-2778870 | 247773 | Q62812 |  | rno:25745 |

PPI pairs:

TRPC5 | TRPM7 | TRPV4

Biological Process:

- GO:0031532 : actin cytoskeleton reorganization
- GO:0030048 : actin filament-based movement
- GO:0001525 : angiogenesis
- GO:0007411 : axon guidance
- GO:0043534 : blood vessel endothelial cell migration
- GO:0016337 : cell-cell adhesion
- GO:0000910 : cytokinesis
- GO:0051295 : establishment of meiotic spindle localization
- GO:0001768 : establishment of T cell polarity
- GO:0001701 : in utero embryonic development
- GO:0007229 : integrin-mediated signaling pathway
- GO:0050900 : leukocyte migration
- GO:0007132 : meiotic metaphase I
- GO:0000212 : meiotic spindle organization
- GO:0006509 : membrane protein ectodomain proteolysis
- GO:0030224 : monocyte differentiation
- GO:0007520 : myoblast fusion
- GO:0030220 : platelet formation
- GO:0015031 : protein transport
- GO:0008360 : regulation of cell shape
- GO:0038032 : termination of G-protein coupled receptor signaling pathway
- GO:0032796 : uropod organization

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:160775 : May-Hegglin anomaly (OMIM:155100 )
- OMIM:160775 : Fechtner syndrome (OMIM:153640 )
- OMIM:160775 : Sebastian syndrome (OMIM:605249 )
- OMIM:160775 : Deafness, autosomal dominant 17 (OMIM:603622 )
- OMIM:160775 : Epstein syndrome (OMIM:153650 )
- OMIM:160775 : Macrothrombocytopenia and progressive sensorineural deafness (OMIM:600208 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC5 |  | Myosin-HIIA | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPM7 |  | Myosin-HIIA | Inference |  |  |  |  |  | Prediction | 16407977
TRPV4 |  | Myosin-HIIA | Affinity purification-mass spectrometry | Mouse | Full-length | Human | HEK293 | Cell lystaes |  | 22492541

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPM7 |  | Myosin-HIIA | Co-immunoprecipitation |  | N1E-115 neuroblastoma cell | Mouse | Full-length | Not used |  | 16407977
TRPM7 |  | Myosin-HIIA | Co-immunoprecipitation | PC12 |  |  |  |  |  | 16407977
TRPV4 |  | Myosin-HIIA | Co-immunofluorescence staining |  | HEK293 | Mouse | Full-length | Not used |  | 22492541

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPM7 |  | Myosin-HIIA | Co-immunoprecipitation | Mouse | 1158-1864 | Mouse | 1795-1960 |  |  | 16407977

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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