# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# HERP / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (6)
- Disease (0)

Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERP)
Official Symbol: HERPUD1 provided by HGNC
Function:
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 9709 | Q15011 | DIP-46662N | Q15011 | MINT-2867283 | 115060 | Q15011 |  | hsa:9709 | 608070
Mouse | 64209 | Q9JJK5 |  |  | UNK-5549399 | 211038 | Q9JJK5 |  | mmu:64209 |
Rat | 85430 | Q9ESS9 |  |  | UNK-5546521 | 250100 | Q9ESS9 |  | rno:85430 |

PPI pairs:

TRPP1

Biological Process:

- GO:0006987 : activation of signaling protein activity involved in unfolded protein response
- GO:0006874 : cellular calcium ion homeostasis
- GO:0043154 : negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0032092 : positive regulation of protein binding
- GO:0031396 : regulation of protein ubiquitination
- GO:0006511 : ubiquitin-dependent protein catabolic process

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | HERP | Inference |  |  |  |  |  | Prediction | 18178578

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | HERP | Co-immunoprecipitation |  | HeLa | Human | Full-length | Mouse | Full-length | 18178578
TRPP1 |  | HERP | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Mouse | Full-length | 19801576

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | HERP | Co-immunoprecipitation | Human | 1-208 | Mouse | Not determined |  |  | 18178578
TRPP1 |  | HERP | Co-immunoprecipitation | Human | 689-968 | Mouse | Not determined |  |  | 18178578

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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