# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPM1 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (3)
- Biological Process (2)
- Disease (1)

Name: Transient receptor potential cation channel subfamily M member 1 (TRPM1)
Official Symbol: TRPM1 provided by HGNC
Function:
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4308 | Q7Z4N2 |  |  |  | 110453 | Q7Z4N2 | 493 | hsa:4308 | 603576
Mouse | 17364 | Q2TV84 |  |  |  | 201440 | Q2TV84 |  | mmu:17364 |
Rat | 361586 | Q2WEA5 |  |  |  | 262795 | Q2WEA5 |  | rno:361586 |

PPI pairs:

GPR179 | Nyctalopin | TRPM3

Biological Process:

- GO:0071482 : cellular response to light stimulus
- GO:0007601 : visual perception

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:603576 : Night blindness, congenital stationary, type 1C (OMIM:613216 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPM1 |  | GPR179 | Inference |  |  |  |  |  | Prediction | 24114537
TRPM1 |  | Nyctalopin | Inference |  |  |  |  |  | Prediction | 21734298
TRPM1 |  | TRPM3 | Inference |  |  |  |  |  | Prediction | 21278253

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPM1 |  | Nyctalopin | Yeast two-hybrid | Mouse | Full-length | Yeast | Mouse | Full-length | Yeast | 21734298

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPM1 |  | GPR179 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 24114537
TRPM1 |  | Nyctalopin | Co-immunofluorescence staining |  | Mouse retinal section | Mouse | Full-length | Mouse | Full-length | 21734298
TRPM1 |  | Nyctalopin | Co-immunoprecipitation |  | HEK293T | Mouse | Full-length | Mouse | Full-length | 21734298
TRPM1 |  | Nyctalopin | Co-immunoprecipitation |  | HEK293T | Mouse | Full-length | Mouse | Full-length | 21832182
TRPM1 |  | TRPM3 | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Mouse | Full-length | 21278253
TRPM1 |  | TRPM3 | Fluorescence resonance energy transfer |  | HEK293 | Rat | Full-length | Mouse | Full-length | 21278253

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPM1 |  | Nyctalopin | Patch clamp |  |  | Activation | 21734298

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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