# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# ID2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (37)
- Disease (0)

Name: DNA-binding protein inhibitor ID-2 (ID2)
Official Symbol: ID2 provided by HGNC
Function:
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 3398 | Q02363 | DIP-46874N | Q02363 | MINT-1372728 | 109624 | Q02363 |  | hsa:3398 | 600386
Mouse | 15902 | P41136 | DIP-167N | P41136 | MINT-217665 | 200506 | P41136 |  | mmu:15902 |
Rat | 25587 | P41137 |  |  |  | 247617 | P41137 |  | rno:25587 |

PPI pairs:

TRPP1

Biological Process:

- GO:0060612 : adipose tissue development
- GO:0003166 : bundle of His development
- GO:0048469 : cell maturation
- GO:0071285 : cellular response to lithium ion
- GO:0090398 : cellular senescence
- GO:0048557 : embryonic digestive tract morphogenesis
- GO:0061031 : endodermal digestive tract morphogenesis
- GO:0009649 : entrainment of circadian clock
- GO:0043353 : enucleate erythrocyte differentiation
- GO:0061030 : epithelial cell differentiation involved in mammary gland alveolus development
- GO:0033598 : mammary gland epithelial cell proliferation
- GO:0001656 : metanephros development
- GO:0001779 : natural killer cell differentiation
- GO:0045578 : negative regulation of B cell differentiation
- GO:0043392 : negative regulation of DNA binding
- GO:2000178 : negative regulation of neural precursor cell proliferation
- GO:0045665 : negative regulation of neuron differentiation
- GO:0048715 : negative regulation of oligodendrocyte differentiation
- GO:0045668 : negative regulation of osteoblast differentiation
- GO:0043433 : negative regulation of sequence-specific DNA binding transcription factor activity
- GO:0000122 : negative regulation of transcription from RNA polymerase II promoter
- GO:0045892 : negative regulation of transcription, DNA-dependent
- GO:0048663 : neuron fate commitment
- GO:0021772 : olfactory bulb development
- GO:0014003 : oligodendrocyte development
- GO:0048541 : Peyer's patch development
- GO:0048711 : positive regulation of astrocyte differentiation
- GO:0045777 : positive regulation of blood pressure
- GO:0045787 : positive regulation of cell cycle
- GO:0071158 : positive regulation of cell cycle arrest
- GO:0045648 : positive regulation of erythrocyte differentiation
- GO:0045600 : positive regulation of fat cell differentiation
- GO:0045651 : positive regulation of macrophage differentiation
- GO:0048661 : positive regulation of smooth muscle cell proliferation
- GO:0071931 : positive regulation of transcription involved in G1/S phase of mitotic cell cycle
- GO:2000045 : regulation of G1/S transition of mitotic cell cycle
- GO:0019216 : regulation of lipid metabolic process

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | ID2 | Yeast two-hybrid | Human | 679-968 | Human | Fetal kidney | cDNA library |  | 16311606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPP1 |  | ID2 | Yeast two-hybrid | Human | 679-968 | Yeast | Human | 1-134 | Yeast | 16311606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | ID2 | Co-immunofluorescence staining |  | HEK293T | Human | Full-length | Not used |  | 16311606
TRPP1 |  | ID2 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Not used |  | 16311606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | ID2 | Yeast two-hybrid | Human | 679-968 | Human | 30-84 |  |  | 16311606

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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