# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# SOD2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (43)
- Disease (1)

Name: Superoxide dismutase [Mn], mitochondrial (SOD2)
Official Symbol: SOD2 provided by HGNC
Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 6648 | P04179 |  | P04179 | MINT-5002369 | 112531 | P04179 |  | hsa:6648 | 147460
Mouse | 20656 | P09671 |  | P09671 |  | 203388 | P09671 |  | mmu:20656 |
Rat | 24787 | P07895 |  | P07895 |  | 246911 | P07895 |  | rno:24787 |

PPI pairs:

TRPC3

Biological Process:

- GO:0001315 : age-dependent response to reactive oxygen species
- GO:0071361 : cellular response to ethanol
- GO:0003032 : detection of oxygen
- GO:0048773 : erythrophore differentiation
- GO:0006749 : glutathione metabolic process
- GO:0007507 : heart development
- GO:0030097 : hemopoiesis
- GO:0050665 : hydrogen peroxide biosynthetic process
- GO:0055072 : iron ion homeostasis
- GO:0001889 : liver development
- GO:0007626 : locomotory behavior
- GO:0008285 : negative regulation of cell proliferation
- GO:0045599 : negative regulation of fat cell differentiation
- GO:0048147 : negative regulation of fibroblast proliferation
- GO:0043524 : negative regulation of neuron apoptotic process
- GO:0048666 : neuron development
- GO:0032364 : oxygen homeostasis
- GO:0045429 : positive regulation of nitric oxide biosynthetic process
- GO:0009791 : post-embryonic development
- GO:0051289 : protein homotetramerization
- GO:0050790 : regulation of catalytic activity
- GO:0051881 : regulation of mitochondrial membrane potential
- GO:0006357 : regulation of transcription from RNA polymerase II promoter
- GO:0001836 : release of cytochrome c from mitochondria
- GO:0019430 : removal of superoxide radicals
- GO:0022904 : respiratory electron transport chain
- GO:0014823 : response to activity
- GO:0048678 : response to axon injury
- GO:0046686 : response to cadmium ion
- GO:0042493 : response to drug
- GO:0051602 : response to electrical stimulus
- GO:0010332 : response to gamma radiation
- GO:0042542 : response to hydrogen peroxide
- GO:0055093 : response to hyperoxia
- GO:0001666 : response to hypoxia
- GO:0033591 : response to L-ascorbic acid
- GO:0032496 : response to lipopolysaccharide
- GO:0010042 : response to manganese ion
- GO:0010269 : response to selenium ion
- GO:0034021 : response to silicon dioxide
- GO:0010043 : response to zinc ion
- GO:0042554 : superoxide anion generation
- GO:0003069 : vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:147460 : Microvascular complications of diabetes 6 (OMIM:612634 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | SOD2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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