# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TGM2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (12)
- Disease (0)

Name: Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
Official Symbol: TGM2 provided by HGNC
Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 7052 | P21980 | DIP-33557N | P21980 | MINT-88880 | 112910 | P21980 |  | hsa:7052 | 190196
Mouse | 21817 | P21981 |  |  | MINT-1869474 | 204168 | P21981 |  | mmu:21817 |
Rat | 56083 | Q6P6R6 |  |  |  | 248561 | Q6P6R6 |  | rno:56083 |

PPI pairs:

TRPV5

Biological Process:

- GO:0043277 : apoptotic cell clearance
- GO:0001974 : blood vessel remodeling
- GO:0060445 : branching involved in salivary gland morphogenesis
- GO:0051482 : elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
- GO:0006917 : induction of apoptosis
- GO:0018153 : isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
- GO:0045785 : positive regulation of cell adhesion
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0050729 : positive regulation of inflammatory response
- GO:0048661 : positive regulation of smooth muscle cell proliferation
- GO:0051260 : protein homooligomerization
- GO:0060662 : salivary gland cavitation

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV5 |  | TGM2 | Inference |  |  |  |  |  | Prediction | 21952826

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPV5 |  | TGM2 | Fusion protein-pull down assay | Mouse | Full-length | HEK293 lysates | Guinea pig | Not specified | Guinea pig liver | 21952826

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV5 |  | TGM2 | Calcium measurement |  |  | Inhibition | 21952826
TRPV5 |  | TGM2 | Cell surface biotinylation |  | Decrease in plasma membrane level |  | 21952826
TRPV5 |  | TGM2 | Patch clamp |  |  | Inhibition | 21952826

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.