# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Cdc42 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (60)
- Disease (0)

Name: Cell division control protein 42 homolog (Cdc42)
Official Symbol: CDC42 provided by HGNC
Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 998 | P60953 | DIP-31097N | P60953 | MINT-94609 | 107433 | P60953 |  | hsa:998 | 116952
Mouse | 12540 | P60766 | DIP-32554N | P60766 | MINT-1602743 | 198627 | P60766 |  | mmu:12540 |
Rat | 64465 | Q8CFN2 | DIP-44072N |  | MINT-3381856 | 249080 | Q8CFN2 |  | rno:64465 |

PPI pairs:

TRPML1

Biological Process:

- GO:0030036 : actin cytoskeleton organization
- GO:0090135 : actin filament branching
- GO:0051017 : actin filament bundle assembly
- GO:0034332 : adherens junction organization
- GO:0007411 : axon guidance
- GO:0007596 : blood coagulation
- GO:0060070 : canonical Wnt signaling pathway
- GO:0003161 : cardiac conduction system development
- GO:0034613 : cellular protein localization
- GO:0007173 : epidermal growth factor receptor signaling pathway
- GO:0090136 : epithelial cell-cell adhesion
- GO:0060684 : epithelial-mesenchymal cell signaling
- GO:0051683 : establishment of Golgi localization
- GO:0035088 : establishment or maintenance of apical/basal cell polarity
- GO:0007163 : establishment or maintenance of cell polarity
- GO:0038096 : Fc-gamma receptor signaling pathway involved in phagocytosis
- GO:0046847 : filopodium assembly
- GO:0007030 : Golgi organization
- GO:0031069 : hair follicle morphogenesis
- GO:0060789 : hair follicle placode formation
- GO:0060047 : heart contraction
- GO:0045087 : innate immune response
- GO:0031424 : keratinization
- GO:0003334 : keratinocyte development
- GO:0030225 : macrophage differentiation
- GO:0035264 : multicellular organism growth
- GO:0042692 : muscle cell differentiation
- GO:0042059 : negative regulation of epidermal growth factor receptor signaling pathway
- GO:0010629 : negative regulation of gene expression
- GO:0031333 : negative regulation of protein complex assembly
- GO:0048664 : neuron fate determination
- GO:0007097 : nuclear migration
- GO:0072384 : organelle transport along microtubule
- GO:0032467 : positive regulation of cytokinesis
- GO:0045740 : positive regulation of DNA replication
- GO:0010628 : positive regulation of gene expression
- GO:0071338 : positive regulation of hair follicle cell proliferation
- GO:0090316 : positive regulation of intracellular protein transport
- GO:0046330 : positive regulation of JNK cascade
- GO:0048554 : positive regulation of metalloenzyme activity
- GO:0051149 : positive regulation of muscle cell differentiation
- GO:0043525 : positive regulation of neuron apoptotic process
- GO:0033138 : positive regulation of peptidyl-serine phosphorylation
- GO:0043552 : positive regulation of phosphatidylinositol 3-kinase activity
- GO:0031274 : positive regulation of pseudopodium assembly
- GO:1900026 : positive regulation of substrate adhesion-dependent cell spreading
- GO:0051835 : positive regulation of synapse structural plasticity
- GO:0051988 : regulation of attachment of spindle microtubules to kinetochore
- GO:0051489 : regulation of filopodium assembly
- GO:0007088 : regulation of mitosis
- GO:0042176 : regulation of protein catabolic process
- GO:0043497 : regulation of protein heterodimerization activity
- GO:0045859 : regulation of protein kinase activity
- GO:0031647 : regulation of protein stability
- GO:0051056 : regulation of small GTPase mediated signal transduction
- GO:0007264 : small GTPase mediated signal transduction
- GO:0002040 : sprouting angiogenesis
- GO:0060661 : submandibular salivary gland formation
- GO:0021762 : substantia nigra development
- GO:0031295 : T cell costimulation

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPML1 |  | Cdc42 | Affinity purification-mass spectrometry | Mouse | Full-length | Mouse | RAW264.7 macrophages | Lysates |  | 23418601

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPML1 |  | Cdc42 | Split-Ubiquitin Yeast two-hybrid | Mouse | Full-length | Yeast | Mouse | Full-length | Yeast | 23418601

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPML1 |  | Cdc42 | Co-immunofluorescence staining |  | RAW264.7 macrophage | Mouse | Full-length | Mouse | Full-length | 23418601
TRPML1 |  | Cdc42 | Co-immunoprecipitation |  | HeLa | Mouse | Full-length | Mouse | Full-length | 23418601

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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