# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation
How to Cite TRIP Database 2.0
Our project needs your support! Please cite following papers when you use TRIP Database in your publications, which is very important to sustain our service:

- Young-Cheul Shin, Soo-Yong Shin, Insuk So, Dongseop Kwon, and Ju-Hong Jeon. "TRIP Database: a manually curated database of protein–protein interactions for mammalian TRP channels." Nucleic acids research 39, no. suppl 1 (2011): D356-D361.
- Young-Cheul Shin, Soo-Yong Shin, Jung Nyeo Chun, Hyeon Sung Cho, Jin Muk Lim, Hong-Gee Kim, Insuk So, Dongseop Kwon, and Ju-Hong Jeon. "TRIP Database 2.0: A Manually Curated Information Hub for Accessing TRP Channel Interaction Network." PloS one 7, no. 10 (2012): e47165.
- Jung Nyeo Chun, Jin Muk Lim, Young Kang, Eung Hee Kim, Young-Cheul Shin, Hong-Gee Kim, Dayk Jang, Dongseop Kwon, Soo-Yong Shin, Insuk So, Ju-Hong Jeon. "A network perspective on unraveling the role of TRP channels in biology and disease."Pflügers Archiv - European Journal of Physiology February 2014, Volume 466, Issue 2, pp 173-182

# TRIP Database 2.0

## a manually curated database of protein-protein interactions for mammalian TRP channels

Transient receptor potential (TRP) channels are a family of Ca2+-permeable cation channels. In response to a wide range of cellular stimuli, they produce electrochemical signals via membrane potential or intracellular [Ca2+]. more info

Aberrant activity of TRP channels has been implicated in its possible role in a variety of human diseases, such as neurological disorders, cardiovascular disease, and cancer [1]. Therefore, TRP channels are regarded as attractive targets for therapeutic intervention.

TRP channels consist of 28 isotypes in mammals. Based on structural and functional similarity, they are divided into 6 subfamilies [2].

- TRPC (canonical): TRPC1-7 (TRPC2 is a pseudogene in human)
- TRPV (vanilloid): TRPV1-6
- TRPM (melastatin): TRPM1-8
- TRPML (mucolipin): TRPML1-3
- TRPP (polycystin): TRPP1-3
- TRPA (ankryin): TRPA1

Accumulating evidence indicates that TRP channels form signalosomes by interacting with many cellular proteins [3]. Because protein-protein interactions (PPIs) are crucial for determining the outcome of most pathophysiological processes [4], the investigation of PPIs of TRP channels will facilitate the understanding of TRP channel biology. In addition, a molecular landscape for TRP channel PPIs can provide insight into the molecular mechanisms by which TRP channels are associated with a diversity of diseases.

To stimulate future researches among scientists who are interested in TRP channel biology, we have developed the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that aims to provide comprehensive information on PPIs of mammalian TRP channels.

The current version of the TRIP Database documents

- PPI pairs: 706
- TRP channels: 28
- Cellular proteins: 436
- Curated articles: 431

1. TRPA1 - AKAP5/AKAP150
2. TRPA1 - CYLD
3. TRPA1 - Orai1
4. TRPA1 - Secretogranin3
5. TRPA1 - STIM1
6. TRPA1 - TRPC1
7. TRPA1 - TRPC6
8. TRPA1 - TRPV1
9. TRPC1 - Bkca
10. TRPC1 - BMPR-2
11. TRPC1 - Calcineurin
12. TRPC1 - Calmodulin
13. TRPC1 - Caspase-1
14. TRPC1 - Caspase-4/Caspase-11
15. TRPC1 - Cav1.2
16. TRPC1 - Caveolin-1
17. TRPC1 - Caveolin-3
18. TRPC1 - Cortactin
19. TRPC1 - D2R
20. TRPC1 - Dystrophin
21. TRPC1 - Enkurin
22. TRPC1 - FGFR-1
23. TRPC1 - FKBP52/FKBP4
24. TRPC1 - Gơq/11
25. TRPC1 - Ƣ-tubulin-5
26. TRPC1 - Homer
27. TRPC1 - Homer-1
28. TRPC1 - Homer-2
29. TRPC1 - Homer-3
30. TRPC1 - I-MFA
31. TRPC1 - IP3R2
32. TRPC1 - IP3R3
33. TRPC1 - MARCKS
34. TRPC1 - MGLUR1
35. TRPC1 - MxA
36. TRPC1 - NCS-1
37. TRPC1 - ơ-actinin
38. TRPC1 - ơ-actinin-1
39. TRPC1 - ơ1-syntrophin
40. TRPC1 - Orai1
41. TRPC1 - Orai2
42. TRPC1 - Orai3
43. TRPC1 - PLCƣ1
44. TRPC1 - PMCA
45. TRPC1 - Protein 4.1
46. TRPC1 - RhoA
47. TRPC1 - RNF24
48. TRPC1 - RyR1
49. TRPC1 - SERCA2
50. TRPC1 - SERCA3
51. TRPC1 - SNAP25
52. TRPC1 - Src
53. TRPC1 - STIM1
54. TRPC1 - STIM2
55. TRPC1 - TRPC3
56. TRPC1 - TRPC4
57. TRPC1 - TRPC5
58. TRPC1 - TRPC6
59. TRPC1 - TRPC7
60. TRPC1 - TRPP1
61. TRPC1 - TRPV4
62. TRPC1 - TRPV6
63. TRPC1 - VAMP
64. TRPC2 - Calmodulin
65. TRPC2 - Caspase-4/Caspase-11
66. TRPC2 - Enkurin
67. TRPC2 - Epo-R
68. TRPC2 - Homer-1
69. TRPC2 - IP3R2
70. TRPC2 - IP3R3
71. TRPC2 - Junctate
72. TRPC2 - PLCƣ1
73. TRPC2 - RTP1
74. TRPC2 - Src
75. TRPC2 - STIM1
76. TRPC2 - TRPC6
77. TRPC3 - 14-3-3 protein Ƣ/ơ
78. TRPC3 - 14-3-3 protein ƥ
79. TRPC3 - 14-3-3 protein ƨ
80. TRPC3 - Aconitase
81. TRPC3 - ADT1
82. TRPC3 - ALDOC
83. TRPC3 - Annexin 5
84. TRPC3 - AP2A2
85. TRPC3 - AP2B1
86. TRPC3 - AQP-2
87. TRPC3 - ATP synthase Ƣ
88. TRPC3 - Basp1
89. TRPC3 - Bkca
90. TRPC3 - Calmodulin
91. TRPC3 - Calreticulin
92. TRPC3 - Caskin-1
93. TRPC3 - CaSR
94. TRPC3 - Cav1.2
95. TRPC3 - Caveolin-1
96. TRPC3 - Citrate synthase
97. TRPC3 - Clathrin-H1
98. TRPC3 - Cytochrome c oxidase 2
99. TRPC3 - Cytochrome c oxidase 5A
100. TRPC3 - DRP-2
101. TRPC3 - Dynamin-1 heavy chain 1
102. TRPC3 - Dynamin-1L
103. TRPC3 - Epo-R
104. TRPC3 - Ezrin
105. TRPC3 - Fibronectin
106. TRPC3 - FKBP12
107. TRPC3 - Fumarase
108. TRPC3 - GC-A
109. TRPC3 - GLUD1
110. TRPC3 - GLUT-4
111. TRPC3 - Gơq
112. TRPC3 - Gơq/11
113. TRPC3 - Gz-ơ
114. TRPC3 - Homer
115. TRPC3 - Homer-1
116. TRPC3 - Idh3B
117. TRPC3 - IP3R1
118. TRPC3 - IP3R2
119. TRPC3 - IP3R3
120. TRPC3 - Junctate
121. TRPC3 - Junctophilin-2
122. TRPC3 - LETM1
123. TRPC3 - MAP2
124. TRPC3 - MDH1
125. TRPC3 - MDH2
126. TRPC3 - MG29
127. TRPC3 - MxA
128. TRPC3 - Myosin-10
129. TRPC3 - NCAM1
130. TRPC3 - NCX1
131. TRPC3 - Neurofascin
132. TRPC3 - Neuromodulin
133. TRPC3 - NKAơ1
134. TRPC3 - NKAơ2
135. TRPC3 - NKAơ3
136. TRPC3 - ơ-actinin
137. TRPC3 - Orai1
138. TRPC3 - Orai2
139. TRPC3 - Orai3
140. TRPC3 - ORP-150
141. TRPC3 - ơSNAP
142. TRPC3 - p97/VCP
143. TRPC3 - PDE3A
144. TRPC3 - PEBP1
145. TRPC3 - PGK1
146. TRPC3 - PKA
147. TRPC3 - PKCƢ
148. TRPC3 - PKG1
149. TRPC3 - PLCƣ1
150. TRPC3 - PLCƣ2
151. TRPC3 - PLCƢ3
152. TRPC3 - PMCA
153. TRPC3 - PMCA2
154. TRPC3 - PMCA3
155. TRPC3 - PMCA4
156. TRPC3 - Pyruvate kinase M1/M2
157. TRPC3 - RACK1
158. TRPC3 - RAP1A
159. TRPC3 - RAP1B
160. TRPC3 - RNF24
161. TRPC3 - RyR
162. TRPC3 - RyR2
163. TRPC3 - SERCA2
164. TRPC3 - Slc1a2
165. TRPC3 - Slc1a3
166. TRPC3 - SNAP23
167. TRPC3 - SNAP25
168. TRPC3 - SOD2
169. TRPC3 - Src
170. TRPC3 - STIM1
171. TRPC3 - STIM2
172. TRPC3 - SV2A
173. TRPC3 - Synapsin1
174. TRPC3 - Synaptotagmin 1
175. TRPC3 - Syntaxin1a
176. TRPC3 - Syntaxin3
177. TRPC3 - Tenascin-R
178. TRPC3 - TrkB
179. TRPC3 - TRPC4
180. TRPC3 - TRPC5
181. TRPC3 - TRPC6
182. TRPC3 - TRPC7
183. TRPC3 - TRPM4
184. TRPC3 - TRPP1
185. TRPC3 - UCH-L1
186. TRPC3 - VAMP2
187. TRPC3 - VAT2
188. TRPC3 - VDAC1
189. TRPC3 - VDAC3
190. TRPC3 - WNK4
191. TRPC4 - 80K-H
192. TRPC4 - Calmodulin
193. TRPC4 - Cav1.2
194. TRPC4 - Caveolin-1
195. TRPC4 - D2R
196. TRPC4 - FKBP5
197. TRPC4 - FKBP52/FKBP4
198. TRPC4 - FYN
199. TRPC4 - GJA1
200. TRPC4 - Gơi2
201. TRPC4 - Ƣ-catenin
202. TRPC4 - ƢV-spectrin
203. TRPC4 - Homer-3
204. TRPC4 - IP3R1
205. TRPC4 - IP3R2
206. TRPC4 - IP3R3
207. TRPC4 - LYN
208. TRPC4 - MxA
209. TRPC4 - NHERF1
210. TRPC4 - NHERF2
211. TRPC4 - ơ1-syntrophin
212. TRPC4 - ơII-spectrin
213. TRPC4 - PLCƣ1
214. TRPC4 - Protein 4.1
215. TRPC4 - RNF24
216. TRPC4 - SESTD1
217. TRPC4 - SHANK
218. TRPC4 - Src
219. TRPC4 - STIM1
220. TRPC4 - TARBP2
221. TRPC4 - TRPC5
222. TRPC4 - TRPC6
223. TRPC4 - TRPP1
224. TRPC4 - VASP
225. TRPC4 - VE-cadherin
226. TRPC4 - ZO-1
227. TRPC5 - AP2B1
228. TRPC5 - CaBP1
229. TRPC5 - Calmodulin
230. TRPC5 - CaMKIIƢ
231. TRPC5 - CAND1
232. TRPC5 - Cav1.2
233. TRPC5 - Clathrin-H1
234. TRPC5 - D2R
235. TRPC5 - Drebrin
236. TRPC5 - Dynamin-1
237. TRPC5 - EF2
238. TRPC5 - Enkurin
239. TRPC5 - FKBP52/FKBP4
240. TRPC5 - Gơi3
241. TRPC5 - ƢII-spectrin
242. TRPC5 - ƢIII-spectrin
243. TRPC5 - Homer-1
244. TRPC5 - Homer-3
245. TRPC5 - IP3R3
246. TRPC5 - Junctate
247. TRPC5 - MxA
248. TRPC5 - Myosin-10
249. TRPC5 - Myosin-5a
250. TRPC5 - Myosin-HIIA
251. TRPC5 - NCS-1
252. TRPC5 - Neurabin-1
253. TRPC5 - Neurabin-2
254. TRPC5 - NHERF1
255. TRPC5 - NKAơ1
256. TRPC5 - NKAơ3
257. TRPC5 - ơ-actinin
258. TRPC5 - ơ-actinin-1
259. TRPC5 - ơ-actinin-4
260. TRPC5 - ơ2-actin
261. TRPC5 - OGDH
262. TRPC5 - ơII-spectrin
263. TRPC5 - RNF24
264. TRPC5 - RyR1
265. TRPC5 - SEC31A
266. TRPC5 - SESTD1
267. TRPC5 - SNAP91
268. TRPC5 - SRA-1
269. TRPC5 - Src
270. TRPC5 - Stathmin1
271. TRPC5 - Stathmin2
272. TRPC5 - Stathmin3
273. TRPC5 - Stathmin4
274. TRPC5 - STIM1
275. TRPC5 - TARBP2
276. TRPC5 - TRF1
277. TRPC5 - TRF2
278. TRPC5 - TRPC6
279. TRPC5 - TRPC7
280. TRPC5 - TUBGCP2
281. TRPC5 - TUBGCP3
282. TRPC5 - UBC
283. TRPC6 - Bkca
284. TRPC6 - Calcineurin
285. TRPC6 - Calmodulin
286. TRPC6 - Cav1.2
287. TRPC6 - Clathrin-H1
288. TRPC6 - Drebrin
289. TRPC6 - Dynamin-1
290. TRPC6 - Epo-R
291. TRPC6 - FKBP12
292. TRPC6 - FYN
293. TRPC6 - GC-A
294. TRPC6 - Gơq/11
295. TRPC6 - IP3R2
296. TRPC6 - IP3R3
297. TRPC6 - M1 mAChR
298. TRPC6 - MxA
299. TRPC6 - Nephrin
300. TRPC6 - NKAơ1
301. TRPC6 - ơ-actinin
302. TRPC6 - Orai1
303. TRPC6 - Orai2
304. TRPC6 - Orai3
305. TRPC6 - PDE3A
306. TRPC6 - PKA
307. TRPC6 - PKCơ
308. TRPC6 - PKG1
309. TRPC6 - PLCƣ1
310. TRPC6 - Podocin
311. TRPC6 - Rab9
312. TRPC6 - RNF24
313. TRPC6 - S100A10
314. TRPC6 - SERCA2
315. TRPC6 - SERCA3
316. TRPC6 - SNAPIN
317. TRPC6 - SNF8
318. TRPC6 - Src
319. TRPC6 - STIM1
320. TRPC6 - Syntaxin3
321. TRPC6 - TRPC7
322. TRPC6 - UBC
323. TRPC7 - Calmodulin
324. TRPC7 - Cav1.2
325. TRPC7 - FKBP12
326. TRPC7 - IP3R3
327. TRPC7 - MxA
328. TRPC7 - PKG1
329. TRPC7 - RNF24
330. TRPC7 - TRPP1
331. TRPM1 - GPR179
332. TRPM1 - Nyctalopin
333. TRPM1 - TRPM3
334. TRPM2 - Calmodulin
335. TRPM2 - EFHC1
336. TRPM2 - PKCơ
337. TRPM2 - PTPL1
338. TRPM2 - Rac1
339. TRPM2 - UBC
340. TRPM3 - Calmodulin
341. TRPM3 - S100A10
342. TRPM3 - UBC
343. TRPM4 - 14-3-3ƣ
344. TRPM4 - Calmodulin
345. TRPM4 - CK1
346. TRPM4 - ƣENaC
347. TRPM4 - SUR1/ABCC8
348. TRPM4 - UBC
349. TRPM6 - PLCƣ1
350. TRPM6 - PLCƣ2
351. TRPM6 - PLCƢ3
352. TRPM6 - RACK1
353. TRPM6 - REA
354. TRPM6 - TRPM7
355. TRPM7 - Annexin 1
356. TRPM7 - ƣ-actin
357. TRPM7 - Myosin-HIIA
358. TRPM7 - PLCƣ1
359. TRPM7 - PLCƣ2
360. TRPM7 - PLCƢ3
361. TRPM7 - PLCƤ1
362. TRPM7 - RACK1
363. TRPM7 - SNAPIN
364. TRPM7 - Synapsin1
365. TRPM7 - Synaptotagmin 1
366. TRPM7 - UBC
367. TRPM8 - 5-HT1B
368. TRPM8 - AKAP5/AKAP150
369. TRPM8 - Gơq
370. TRPM8 - OPRM1
371. TRPM8 - PIRT
372. TRPML1 - ALG-2/PDCD6
373. TRPML1 - Cdc42
374. TRPML1 - ERIGC3
375. TRPML1 - HOP/STI1
376. TRPML1 - HSC70
377. TRPML1 - HSP40/DNAJB1
378. TRPML1 - HSP40/DNAJC14
379. TRPML1 - HSP90
380. TRPML1 - LAPTM4a
381. TRPML1 - LAPTM4b
382. TRPML1 - LAPTM5
383. TRPML1 - NDKA
384. TRPML1 - NovelProtein/NP9
385. TRPML1 - PEA-15
386. TRPML1 - Peroxisomal membrane protein 2
387. TRPML1 - PEX16
388. TRPML1 - PIP5K1A
389. TRPML1 - PKA
390. TRPML1 - Rac1
391. TRPML1 - Rac2
392. TRPML1 - RFP/TRIM27
393. TRPML1 - RhoG
394. TRPML1 - SEC13
395. TRPML1 - SEC31A
396. TRPML1 - SLC35E1
397. TRPML1 - STOML1
398. TRPML1 - TMEM163
399. TRPML1 - TPC1
400. TRPML1 - TPC2
401. TRPML1 - TRPML2
402. TRPML1 - TRPML3
403. TRPML1 - Unnamed protein (BAE)
404. TRPML1 - YIF1B
405. TRPML2 - HSC70
406. TRPML2 - TRPML3
407. TRPML3 - GATE16
408. TRPML3 - HSC70
409. TRPML3 - TPC1
410. TRPML3 - TPC2
411. TRPML3 - TRPV5
412. TRPML3 - TRPV6
413. TRPP1 - 80K-H
414. TRPP1 - ABHD12
415. TRPP1 - ATP13A1
416. TRPP1 - BAG2
417. TRPP1 - BRI3BP
418. TRPP1 - Calnexin
419. TRPP1 - CD2AP
420. TRPP1 - CDKAL1
421. TRPP1 - CISD2
422. TRPP1 - Cullin-1
423. TRPP1 - DHRS7B
424. TRPP1 - DIAP1/DRF1
425. TRPP1 - EGFR
426. TRPP1 - eIF2ơ
427. TRPP1 - EPHA2
428. TRPP1 - ERLIN2
429. TRPP1 - FAF2
430. TRPP1 - Filamin-A
431. TRPP1 - ƣ-adaptin
432. TRPP1 - Ƣ-Trcp1
433. TRPP1 - Ƣ-Trcp2
434. TRPP1 - H2-D1
435. TRPP1 - H2-K1
436. TRPP1 - HAX-1
437. TRPP1 - HDAC6
438. TRPP1 - HERP
439. TRPP1 - HSP40/DNAJA1
440. TRPP1 - ID2
441. TRPP1 - IFIT1
442. TRPP1 - IFT57
443. TRPP1 - IP3R1
444. TRPP1 - IP3R3
445. TRPP1 - KIF3A
446. TRPP1 - KIF3B
447. TRPP1 - KIM1/TIM1
448. TRPP1 - KRAS
449. TRPP1 - LAP2/TMPO
450. TRPP1 - LETMD1
451. TRPP1 - MGST1
452. TRPP1 - NEK8
453. TRPP1 - Numb
454. TRPP1 - Nup155
455. TRPP1 - ơ-actinin
456. TRPP1 - ơ-actinin-1
457. TRPP1 - ơ-actinin-2
458. TRPP1 - p97/VCP
459. TRPP1 - PACS-1
460. TRPP1 - PACS-2
461. TRPP1 - Paraoxonase 3
462. TRPP1 - PDIA3/GRP58
463. TRPP1 - Pericentrin
464. TRPP1 - PERK
465. TRPP1 - PGAM5
466. TRPP1 - Piezo1
467. TRPP1 - PIGEA-14/CBY1
468. TRPP1 - PKA
469. TRPP1 - PKD1/Polycystin-1
470. TRPP1 - PKD1L1/Polycystin-1L1
471. TRPP1 - PKHD1/FPC
472. TRPP1 - PLCƣ2
473. TRPP1 - PSMD7
474. TRPP1 - PTP1B
475. TRPP1 - RAB12
476. TRPP1 - RAB14
477. TRPP1 - RAB18
478. TRPP1 - RAB21
479. TRPP1 - RAB7
480. TRPP1 - RAD50
481. TRPP1 - RCHY1/PIRH2
482. TRPP1 - Ribophorin I
483. TRPP1 - Ribophorin II
484. TRPP1 - RP2
485. TRPP1 - RTP4
486. TRPP1 - RyR2
487. TRPP1 - SEC22B
488. TRPP1 - SEC61B
489. TRPP1 - SERCA2
490. TRPP1 - SGPL1
491. TRPP1 - SKP1
492. TRPP1 - SRPRB
493. TRPP1 - SSFA2
494. TRPP1 - ST7
495. TRPP1 - SUN3
496. TRPP1 - Syntaxin5
497. TRPP1 - TAP1
498. TRPP1 - TAP2
499. TRPP1 - Tapasin
500. TRPP1 - TAZ/WWTR1
501. TRPP1 - TBL2
502. TRPP1 - TFRC
503. TRPP1 - TMEM120a
504. TRPP1 - TMEM209
505. TRPP1 - TMEM48/NDC1
506. TRPP1 - TMEM59
507. TRPP1 - TOR1AIP1/LAB1B
508. TRPP1 - TRIM59
509. TRPP1 - Tropomyosin 1
510. TRPP1 - Troponin I 1
511. TRPP1 - Troponin I 2
512. TRPP1 - Troponin I 3
513. TRPP1 - TRPV4
514. TRPP1 - TTC35
515. TRPP1 - TYW1
516. TRPP1 - UBC
517. TRPP1 - UHRF1
518. TRPP1 - USE1
519. TRPP1 - VAMPA
520. TRPP1 - VAMPB
521. TRPP1 - VDAC3
522. TRPP1 - Viperin
523. TRPP1 - VRK2
524. TRPP1 - VTI1B
525. TRPP2 - ơ-actinin
526. TRPP2 - ơ-actinin-1
527. TRPP2 - ơ-actinin-2
528. TRPP2 - PKD1/Polycystin-1
529. TRPP2 - PKD1L3/Polycystin-1L3
530. TRPP2 - Troponin I 1
531. TRPP2 - Troponin I 2
532. TRPP2 - Troponin I 3
533. TRPP3 - RACK1
534. TRPV1 - 80K-H
535. TRPV1 - Actin
536. TRPV1 - AKAP5/AKAP150
537. TRPV1 - Akt
538. TRPV1 - AMPKơ2
539. TRPV1 - Apolipoprotein O
540. TRPV1 - Bkca
541. TRPV1 - Calmodulin
542. TRPV1 - CaMKII
543. TRPV1 - Catenin-ơ2
544. TRPV1 - Catenin-Ƥ2
545. TRPV1 - CB1
546. TRPV1 - Cbl
547. TRPV1 - CDK12
548. TRPV1 - CDK5
549. TRPV1 - CHERP
550. TRPV1 - Contactin-1
551. TRPV1 - DAP-150
552. TRPV1 - DAZAP2
553. TRPV1 - E-cadherin
554. TRPV1 - Eferin/Rab11-FIP3
555. TRPV1 - EGFR
556. TRPV1 - eNOS
557. TRPV1 - FAF1
558. TRPV1 - GABARAP
559. TRPV1 - GCN5
560. TRPV1 - Glucose 6 phosphatase
561. TRPV1 - Glycogen phosphorylase
562. TRPV1 - Ƣ-arrestin 2
563. TRPV1 - Ƣ-catenin
564. TRPV1 - Ƣ-tubulin-3
565. TRPV1 - Ƣ-tubulin-5
566. TRPV1 - HAX-1
567. TRPV1 - ITM2C
568. TRPV1 - JMJD2C
569. TRPV1 - KCNQ2
570. TRPV1 - KCNQ3
571. TRPV1 - KIF13B
572. TRPV1 - KIF2A
573. TRPV1 - KIF3B
574. TRPV1 - KPNƢ1
575. TRPV1 - KvƢ2
576. TRPV1 - Neuronatin
577. TRPV1 - NKX2.2
578. TRPV1 - NMDAR1
579. TRPV1 - NMDAR2B
580. TRPV1 - NOMO1
581. TRPV1 - ơ-tubulin-1A
582. TRPV1 - ơ-tubulin-1B
583. TRPV1 - ơENaC
584. TRPV1 - ơII-spectrin
585. TRPV1 - OS-9
586. TRPV1 - P2RX3
587. TRPV1 - PACS-1
588. TRPV1 - PEX10
589. TRPV1 - PI3K-p85Ƣ
590. TRPV1 - PI3K-p85ơ
591. TRPV1 - PIRT
592. TRPV1 - PKA
593. TRPV1 - PKARIIơ
594. TRPV1 - PKC
595. TRPV1 - PKCƢ
596. TRPV1 - PKCƥ
597. TRPV1 - PLAGL1
598. TRPV1 - PLCƣ1
599. TRPV1 - POLR2G
600. TRPV1 - POLR3D
601. TRPV1 - PPARơ
602. TRPV1 - PRKD1/PKCƬ
603. TRPV1 - RAB26
604. TRPV1 - RAB8b
605. TRPV1 - RANBP9
606. TRPV1 - Ribosomal protein L9
607. TRPV1 - RPL12
608. TRPV1 - RyR1
609. TRPV1 - SGT
610. TRPV1 - SMA3
611. TRPV1 - SNAPIN
612. TRPV1 - snRNP 70
613. TRPV1 - Src
614. TRPV1 - Synaptotagmin 1
615. TRPV1 - Synaptotagmin 4
616. TRPV1 - TAK1
617. TRPV1 - TGS1
618. TRPV1 - Thrombospondin-3
619. TRPV1 - TMEM115
620. TRPV1 - TrkA
621. TRPV1 - TRPV2
622. TRPV1 - TRPV3
623. TRPV1 - Tubulin
624. TRPV1 - UBP5
625. TRPV1 - ZBTB17
626. TRPV1 - ZO-1
627. TRPV2 - ACBD3
628. TRPV2 - AKAP5/AKAP150
629. TRPV2 - Calmodulin
630. TRPV2 - PKA
631. TRPV2 - PKARIIơ
632. TRPV2 - RGA/RAG1AP1
633. TRPV2 - SYNE1
634. TRPV2 - UBC
635. TRPV3 - AKAP5/AKAP150
636. TRPV3 - Calmodulin
637. TRPV3 - EGFR
638. TRPV4 - 80K-H
639. TRPV4 - AKAP5/AKAP150
640. TRPV4 - AQP-4
641. TRPV4 - AQP-5
642. TRPV4 - AT1aR
643. TRPV4 - Bkca
644. TRPV4 - Calmodulin
645. TRPV4 - Caveolin-1
646. TRPV4 - E-cadherin
647. TRPV4 - FYN
648. TRPV4 - ƣ-actin
649. TRPV4 - Ƣ-arrestin 1
650. TRPV4 - Ƣ-arrestin 2
651. TRPV4 - Ƣ-catenin
652. TRPV4 - Ƣ-tubulin-5
653. TRPV4 - HCK
654. TRPV4 - IP3R3
655. TRPV4 - ITCH/AIP4
656. TRPV4 - LCK
657. TRPV4 - LYN
658. TRPV4 - MAP7
659. TRPV4 - Myosin-10
660. TRPV4 - Myosin-HIIA
661. TRPV4 - NHERF4
662. TRPV4 - ơ2-integrin
663. TRPV4 - OS-9
664. TRPV4 - PACS-1
665. TRPV4 - Pacsin1
666. TRPV4 - Pacsin2
667. TRPV4 - Pacsin3
668. TRPV4 - RPS27A
669. TRPV4 - Src
670. TRPV4 - TMEM16A/ANO1
671. TRPV4 - Tubulin
672. TRPV4 - UBC
673. TRPV4 - YES
674. TRPV5 - 80K-H
675. TRPV5 - BSPRY
676. TRPV5 - Calbindin-D28K
677. TRPV5 - Calmodulin
678. TRPV5 - Cyclophilin B
679. TRPV5 - EWSR1
680. TRPV5 - FKBP52/FKBP4
681. TRPV5 - Galectin-1
682. TRPV5 - Klotho
683. TRPV5 - NHERF2
684. TRPV5 - NHERF4
685. TRPV5 - Nipsnap1
686. TRPV5 - Rab11a
687. TRPV5 - S100A10
688. TRPV5 - TGM2
689. TRPV5 - TRPV6
690. TRPV6 - BSPRY
691. TRPV6 - Calbindin-D28K
692. TRPV6 - Calmodulin
693. TRPV6 - Cyclophilin B
694. TRPV6 - FYN
695. TRPV6 - I-MFA
696. TRPV6 - Klotho
697. TRPV6 - NHERF4
698. TRPV6 - Nipsnap1
699. TRPV6 - Numb
700. TRPV6 - PTEN
701. TRPV6 - PTP1B
702. TRPV6 - Rab11a
703. TRPV6 - RGS2
704. TRPV6 - RyR1
705. TRPV6 - S100A10
706. TRPV6 - Src

The TRIP Database provides comprehensive information on PPIs of mammalian TRP channels with 4 categories. more info

The TRIP Database provides a detailed summary of PPI data, which fits into 4 categories: screening, validation, characterization, and functional consequence. These categorizations give answers for four basic questions about PPIs: how to identify PPIs (screening); how to confirm PPIs (validation); what are biochemical properties of PPIs (characterization); what are biological meaning of PPIs (functional consequence). Users can find in-depth information specified in the literature on relevant analytical methods, gene constructs, and cell/tissue types. The TRIP Database has a user-friendly interface with several helpful features, including a search engine, an interaction map, and a function for cross-referencing useful external databases.

Major updates in the TRIP Database 2.0:

1. The database contents have updated by manually curating the new publications: 56% increase in the number of indexed articles (431 from 277 peer-reviewed publications), 44% increase in the number of PPI pairs (706 from 490 PPI pairs), and 47% increase in the number of cellular proteins (436 from 297 proteins). In addition, the supplementary data of all referred articles are also scrutinized and curated.
2. The database contents can be downloaded as a MS Excel format or a sif format for network visualization and analysis using "Cytoscape (http://www.cytoscape.org)".
3. Users can make comments on each web page, which enables interactive communication.
4. Users can print each page content of the database.
5. The search system presents information from "Pubmed (http://www.ncbi.nlm.nih.gov/pubmed)" and "PIE the search (http://www.ncbi.nlm.nih.gov/IRET/PIE)" which is the specialized search engine for PPI-related articles as well as information shown in previous version.
6. Users easily grasp overall PPI information through PPI matrix table according to TRP channel subfamily.
7. Accessibility to relevant information has been improved various ways: mouse-over pop-up help messages and integration of new information sources, including GO (Gene Ontology) terms and disease information from OMIM (Online Mendelian Inheritance in Man).

### TRIP Database News

### Citing Articles of TRIP Database

### Useful Links

1. Transporter Classification Database (http://www.tcdb.org)
2. Human Membrane Transporter Database (http://lab.digibench.net/transporter)
3. IUBMB Membrane Transport Protein Nomenclature (http://www.chem.qmul.ac.uk/iubmb/mtp)
4. TransportDB (http://www.membranetransport.org)
5. ΔG prediction of transmembrane helix insertion (http://dgpred.cbr.su.se)
6. Transmembrane helix prediction (http://www.csbio.sjtu.edu.cn/bioinf/MemBrain)
7. Prediction of membrane protein topology and signal peptides (http://octopus.cbr.su.se)
8. Domains and Motifs in Transmembrane Proteins (http://topdom.enzim.hu/?m=search&by=seq)
9. Classification and Secondary Structure Prediction of Membrane Proteins (http://bp.nuap.nagoya-u.ac.jp/sosui)
10. Wikipedia: Transient receptor potential channel-interacting protein database

### Special thanks

We cordially thank many members of the Korean Physiology Society and the Korean Society for Ion Channel Research for helpful discussions and comments on database contents and user-interfaces.

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