# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# HAX-1 / TRP channels

- Basic Information
- External Database
- PPI pairs (2)
- Biological Process (9)
- Disease (1)

Name: HCLS1-associated protein X-1 (HAX-1)
Official Symbol: HAX1 provided by HGNC
Function:
Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 10456 | O00165 | DIP-36771N | O00165 | MINT-1137395 | 115719 | O00165 |  | hsa:10456 | 605998
Mouse | 23897 | O35387 | DIP-49445N | O35387 | MINT-1592061 | 204783 | O35387 |  | mmu:23897 |
Rat | 291202 | Q7TSE9 | DIP-36767N | Q7TSE9 |  | 253448 | Q7TSE9 |  | rno:291202 |

PPI pairs:

TRPP1 | TRPV1

Biological Process:

- GO:0071345 : cellular response to cytokine stimulus
- GO:2000251 : positive regulation of actin cytoskeleton reorganization
- GO:0030854 : positive regulation of granulocyte differentiation
- GO:0033138 : positive regulation of peptidyl-serine phosphorylation
- GO:0050731 : positive regulation of peptidyl-tyrosine phosphorylation
- GO:0014068 : positive regulation of phosphatidylinositol 3-kinase cascade
- GO:0051897 : positive regulation of protein kinase B signaling cascade
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0030833 : regulation of actin filament polymerization

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:605998 : Neutropenia, severe congenital 3, autosomal recessive (OMIM:610738 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Mouse | Embryonic | cDNA library |  | 10760273
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Human | Kidney | cDNA library |  | 10760273
TRPV1 |  | HAX-1 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Yeast | Mouse | 94-280 | Yeast | 10760273

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | HAX-1 | Co-immunofluorescence staining |  | HeLa | Human | Full-length | Mouse | Full-length | 10760273
TRPP1 |  | HAX-1 | Co-immunoprecipitation |  | HeLa | Human | Full-length | Mouse | Full-length | 10760273

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Mouse | 179-280 |  |  | 10760273

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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