# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Dystrophin / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (18)
- Disease (3)

Name: Dystrophin (Dystrophin)
Official Symbol: DMD provided by HGNC
Function:
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 1756 | P11532 | DIP-32593N | P11532 | MINT-109755 | 108096 | P11532 |  | hsa:1756 | 300377
Mouse | 13405 | P11531 | DIP-32899N | P11531 | MINT-85369 | 199245 | P11531 |  | mmu:13405 |
Rat | 24907 | P11530 | DIP-33674N | P11530 | UNK-5371352 | 247015 | P11530 |  | rno:24907 |

PPI pairs:

TRPC1

Biological Process:

- GO:0060048 : cardiac muscle contraction
- GO:0043623 : cellular protein complex assembly
- GO:0046716 : muscle cell homeostasis
- GO:0030049 : muscle filament sliding
- GO:0007517 : muscle organ development
- GO:0033137 : negative regulation of peptidyl-serine phosphorylation
- GO:0048812 : neuron projection morphogenesis
- GO:0045213 : neurotransmitter receptor metabolic process
- GO:0021629 : olfactory nerve structural organization
- GO:0043043 : peptide biosynthetic process
- GO:0086001 : regulation of cardiac muscle cell action potential
- GO:0010881 : regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- GO:0002027 : regulation of heart rate
- GO:2000169 : regulation of peptidyl-cysteine S-nitrosylation
- GO:0060314 : regulation of ryanodine-sensitive calcium-release channel activity
- GO:0014809 : regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
- GO:0006355 : regulation of transcription, DNA-dependent
- GO:0007519 : skeletal muscle tissue development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:300377 : Duchenne muscular dystrophy (OMIM:310200 )
- OMIM:300377 : Becker muscular dystrophy (OMIM:300376 )
- OMIM:300377 : Cardiomyopathy, dilated, 3B (OMIM:302045 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | Dystrophin | Inference |  |  |  |  |  | Prediction | 17202249

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | Dystrophin | Co-immunofluorescence staining | SolC57 |  |  |  |  |  | 17202249
TRPC1 |  | Dystrophin | Co-immunoprecipitation | Mouse hind limb muscle |  |  |  |  |  | 17202249
TRPC1 |  | Dystrophin | Co-immunoprecipitation | SolC57 |  |  |  |  |  | 17202249

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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