# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# GC-A / TRP channels

- Basic Information
- External Database
- PPI pairs (2)
- Biological Process (14)
- Disease (0)

Name: Atrial natriuretic peptide receptor 1 (GC-A)
Official Symbol: NPR1 provided by HGNC
Function:
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4881 | P16066 | DIP-46246N | P16066 | MINT-1192002 | 110941 | P16066 |  | hsa:4881 | 108960
Mouse | 18160 | P18293 |  |  | UNK-5372812 | 201830 | P18293 |  | mmu:18160 |
Rat | 24603 | P18910 |  |  | UNK-5360342 | 246742 | P18910 |  | rno:24603 |

PPI pairs:

TRPC3 | TRPC6

Biological Process:

- GO:0007589 : body fluid secretion
- GO:0042417 : dopamine metabolic process
- GO:0035556 : intracellular signal transduction
- GO:0016525 : negative regulation of angiogenesis
- GO:0030308 : negative regulation of cell growth
- GO:0048662 : negative regulation of smooth muscle cell proliferation
- GO:0030828 : positive regulation of cGMP biosynthetic process
- GO:0035815 : positive regulation of renal sodium excretion
- GO:0035810 : positive regulation of urine volume
- GO:0007168 : receptor guanylyl cyclase signaling pathway
- GO:0008217 : regulation of blood pressure
- GO:0050880 : regulation of blood vessel size
- GO:0043114 : regulation of vascular permeability
- GO:0042312 : regulation of vasodilation

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | GC-A | Inference |  |  |  |  |  | Prediction | 22027011
TRPC6 |  | GC-A | Inference |  |  |  |  |  | Prediction | 22027011

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | GC-A | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011
TRPC3 |  | GC-A | Co-immunoprecipitation |  | Mouse cardiac myocyte lysates | Not used |  | Rat | Full-length | 22027011
TRPC3 |  | GC-A | Fluorescence resonance energy transfer |  | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011
TRPC6 |  | GC-A | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011
TRPC6 |  | GC-A | Co-immunoprecipitation |  | Mouse cardiac myocyte lysates | Not used |  | Rat | Full-length | 22027011

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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