# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Filamin-A / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (19)
- Disease (10)

Name: Filamin-A (Filamin-A)
Official Symbol: FLNA provided by HGNC
Function:
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 2316 | P21333 | DIP-1136N | P21333 | MINT-118283 | 108605 | P21333 |  | hsa:2316 | 300017
Mouse | 192176 | Q8BTM8 | DIP-44114N | Q8BTM8 | MINT-1867095 | 228662 | Q8BTM8 |  | mmu:192176 |
Rat | 293860 | C0JPT7 |  | C0JPT7 |  | 254490 | C0JPT7 |  | rno:293860 |

PPI pairs:

TRPP1

Biological Process:

- GO:0051764 : actin crosslink formation
- GO:0031532 : actin cytoskeleton reorganization
- GO:0007195 : adenylate cyclase-inhibiting dopamine receptor signaling pathway
- GO:0034329 : cell junction assembly
- GO:0042384 : cilium assembly
- GO:0051220 : cytoplasmic sequestering of protein
- GO:0045022 : early endosome to late endosome transport
- GO:0001837 : epithelial to mesenchymal transition
- GO:0045184 : establishment of protein localization
- GO:0042177 : negative regulation of protein catabolic process
- GO:0043433 : negative regulation of sequence-specific DNA binding transcription factor activity
- GO:0030168 : platelet activation
- GO:0002576 : platelet degranulation
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0042993 : positive regulation of transcription factor import into nucleus
- GO:0034394 : protein localization to cell surface
- GO:0050821 : protein stabilization
- GO:0043113 : receptor clustering
- GO:0090307 : spindle assembly involved in mitosis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:300017 : Heterotopia, periventricular (OMIM:300049 )
- OMIM:300017 : Otopalatodigital syndrome, type I (OMIM:311300 )
- OMIM:300017 : Otopalatodigital syndrome, type II (OMIM:304120 )
- OMIM:300017 : Intestinal pseudoobstruction, neuronal (OMIM:300048 )
- OMIM:300017 : Melnick-Needles syndrome (OMIM:309350 )
- OMIM:300017 : Frontometaphyseal dysplasia (OMIM:305620 )
- OMIM:300017 : Heterotopia, periventricular, ED variant (OMIM:300537 )
- OMIM:300017 : FG syndrome 2 (OMIM:300321 )
- OMIM:300017 : Cardiac valvular dysplasia, X-linked (OMIM:314400 )
- OMIM:300017 : Terminal osseous dysplasia (OMIM:300244 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | Filamin-A | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | Filamin-A | Co-immunoprecipitation | COS-7 |  |  |  |  |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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