# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# GJA1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (28)
- Disease (6)

Name: Gap junction alpha-1 protein (GJA1)
Official Symbol: GJA1 provided by HGNC
Function:
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 2697 | P17302 | DIP-36790N | P17302 | MINT-147603 | 108964 | P17302 |  | hsa:2697 | 121014
Mouse | 14609 | P23242 | DIP-29207N | P23242 | MINT-1326689 | 199923 | P23242 |  | mmu:14609 |
Rat | 24392 | P08050 | DIP-34793N | P08050 | MINT-1791096 | 246562 | P08050 |  | rno:24392 |

PPI pairs:

TRPC4

Biological Process:

- GO:0007512 : adult heart development
- GO:0006915 : apoptotic process
- GO:0015867 : ATP transport
- GO:0048514 : blood vessel morphogenesis
- GO:0007267 : cell-cell signaling
- GO:0016044 : cellular membrane organization
- GO:0002070 : epithelial cell maturation
- GO:0016264 : gap junction assembly
- GO:0007507 : heart development
- GO:0001947 : heart looping
- GO:0001701 : in utero embryonic development
- GO:0060174 : limb bud formation
- GO:0006936 : muscle contraction
- GO:0008285 : negative regulation of cell proliferation
- GO:0010629 : negative regulation of gene expression
- GO:0001764 : neuron migration
- GO:0048812 : neuron projection morphogenesis
- GO:0010628 : positive regulation of gene expression
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0045732 : positive regulation of protein catabolic process
- GO:0045844 : positive regulation of striated muscle tissue development
- GO:0051259 : protein oligomerization
- GO:0051924 : regulation of calcium ion transport
- GO:0008016 : regulation of heart contraction
- GO:0043434 : response to peptide hormone stimulus
- GO:0009268 : response to pH
- GO:0043403 : skeletal muscle tissue regeneration
- GO:0010232 : vascular transport

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:121014 : Oculodentodigital dysplasia (OMIM:164200 )
- OMIM:121014 : Syndactyly, type III (OMIM:186100 )
- OMIM:121014 : Hypoplastic left heart syndrome 1 (OMIM:241550 )
- OMIM:121014 : Atrioventricular septal defect 3 (OMIM:600309 )
- OMIM:121014 : Oculodentodigital dysplasia, autosomal recessive (OMIM:257850 )
- OMIM:121014 : Hallermann-Streiff syndrome (OMIM:234100 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC4 |  | GJA1 | Inference |  |  |  |  |  | Prediction | 15540229

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC4 |  | GJA1 | Co-immunofluorescence staining | Human fetal brain astrocytes |  |  |  |  |  | 15540229
TRPC4 |  | GJA1 | Co-immunoprecipitation | Human fetal brain astrocytes |  |  |  |  |  | 15540229

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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