# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# CYLD / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (14)
- Disease (3)

Name: Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)
Official Symbol: CYLD provided by HGNC
Function:
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 1540 | Q9NQC7 | DIP-51657N | Q9NQC7 | MINT-6804518 | 107920 | Q9NQC7 |  | hsa:1540 | 605018
Mouse | 74256 | Q80TQ2 | DIP-35656N | Q80TQ2 | MINT-7561827 | 216612 | Q80TQ2 |  | mmu:74256 |
Rat | 312937 | Q66H62 |  |  |  | 260280 | Q66H62 |  | rno:312937 |

PPI pairs:

TRPA1

Biological Process:

- GO:0007049 : cell cycle
- GO:0006917 : induction of apoptosis
- GO:0045087 : innate immune response
- GO:0090090 : negative regulation of canonical Wnt receptor signaling pathway
- GO:0042347 : negative regulation of NF-kappaB import into nucleus
- GO:0032088 : negative regulation of NF-kappaB transcription factor activity
- GO:0032480 : negative regulation of type I interferon production
- GO:0070423 : nucleotide-binding oligomerization domain containing signaling pathway
- GO:2001238 : positive regulation of extrinsic apoptotic signaling pathway
- GO:0070536 : protein K63-linked deubiquitination
- GO:0070507 : regulation of microtubule cytoskeleton organization
- GO:0007346 : regulation of mitotic cell cycle
- GO:0006511 : ubiquitin-dependent protein catabolic process
- GO:0016055 : Wnt receptor signaling pathway

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:605018 : Cylindromatosis, familial (OMIM:132700 )
- OMIM:605018 : Brooke-Spiegler syndrome (OMIM:605041 )
- OMIM:605018 : Trichoepithelioma, multiple familial, 1 (OMIM:601606 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPA1 |  | CYLD | Inference |  |  |  |  |  | Prediction | 16500080

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPA1 |  | CYLD | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 16500080
TRPA1 |  | CYLD | Co-immunoprecipitation |  | MDA-MB-435 | Not used |  | Human | Full-length | 16500080
TRPA1 |  | CYLD | Co-immunoprecipitation | Human Jurkat T cell |  |  |  |  |  | 16500080

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPA1 |  | CYLD | In vivo PTM assay | De-ubiquitination |  |  | 16500080

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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