# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# SNAP25 / TRP channels

- Basic Information
- External Database
- PPI pairs (2)
- Biological Process (14)
- Disease (0)

Name: Synaptosomal-associated protein 25 (SNAP25)
Official Symbol: SNAP25 provided by HGNC
Function:
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 6616 | P60880 | DIP-34554N | P60880 | MINT-1403389 | 112500 | P60880 |  | hsa:6616 | 600322
Mouse | 20614 | P60879 | DIP-29066N DIP-65N | P60879 | MINT-2411221 | 203362 | P60879 |  | mmu:20614 |
Rat | 25012 | P60881 | DIP-29205N DIP-29593N | P60881 | MINT-95953 | 247095 | P60881 |  | rno:25012 |

PPI pairs:

TRPC1 | TRPC3

Biological Process:

- GO:0007409 : axonogenesis
- GO:0048791 : calcium ion-dependent exocytosis of neurotransmitter
- GO:0016197 : endosomal transport
- GO:0006112 : energy reserve metabolic process
- GO:0014047 : glutamate secretion
- GO:0030252 : growth hormone secretion
- GO:0007616 : long-term memory
- GO:0001504 : neurotransmitter uptake
- GO:0032024 : positive regulation of insulin secretion
- GO:0050796 : regulation of insulin secretion
- GO:0051963 : regulation of synapse assembly
- GO:0030431 : sleep
- GO:0044281 : small molecule metabolic process
- GO:0016081 : synaptic vesicle docking involved in exocytosis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | SNAP25 | Inference |  |  |  |  |  | Prediction | 15121806
TRPC3 |  | SNAP25 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | SNAP25 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 15121806

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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