# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# PEBP1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (23)
- Disease (0)

Name: Phosphatidylethanolamine-binding protein 1 (PEBP1)
Official Symbol: PEBP1 provided by HGNC
Function:
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5037 | P30086 |  | P30086 | MINT-5002544 | 111076 | P30086 |  | hsa:5037 | 604591
Mouse | 23980 | P70296 |  | P70296 |  | 204834 | P70296 |  | mmu:23980 |
Rat | 29542 | P31044 |  |  |  | 248176 | P31044 |  | rno:29542 |

PPI pairs:

TRPC3

Biological Process:

- GO:0007568 : aging
- GO:0007420 : brain development
- GO:0042755 : eating behavior
- GO:0000165 : MAPK cascade
- GO:0043409 : negative regulation of MAPK cascade
- GO:0001933 : negative regulation of protein phosphorylation
- GO:0060409 : positive regulation of acetylcholine metabolic process
- GO:0043950 : positive regulation of cAMP-mediated signaling
- GO:0045840 : positive regulation of mitosis
- GO:0001505 : regulation of neurotransmitter levels
- GO:0002026 : regulation of the force of heart contraction
- GO:0014823 : response to activity
- GO:0051592 : response to calcium ion
- GO:0051591 : response to cAMP
- GO:0051412 : response to corticosterone stimulus
- GO:0042493 : response to drug
- GO:0051602 : response to electrical stimulus
- GO:0045471 : response to ethanol
- GO:0009408 : response to heat
- GO:0006979 : response to oxidative stress
- GO:0009636 : response to toxin
- GO:0009611 : response to wounding
- GO:0007286 : spermatid development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | PEBP1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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