# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# CaSR / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (6)
- Disease (5)

Name: Extracellular calcium-sensing receptor (CaSR)
Official Symbol: CASR provided by HGNC
Function:
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 846 | P41180 | DIP-5975N | P41180 |  | 107296 | P41180 |  | hsa:846 | 601199
Mouse | 12374 | Q9QY96 |  |  |  | 198504 | Q9QY96 |  | mmu:12374 |
Rat | 24247 | P48442 |  | P48442 |  | 246432 | P48442 |  | rno:24247 |

PPI pairs:

TRPC3

Biological Process:

- GO:0009653 : anatomical structure morphogenesis
- GO:0070509 : calcium ion import
- GO:0006874 : cellular calcium ion homeostasis
- GO:0007635 : chemosensory behavior
- GO:0005513 : detection of calcium ion
- GO:0001503 : ossification

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:601199 : Hypocalciuric hypercalcemia, type I (OMIM:145980 )
- OMIM:601199 : Hyperparathyroidism, neonatal (OMIM:239200 )
- OMIM:601199 : Hypocalcemia, autosomal dominant (OMIM:146200 )
- OMIM:601199 : Hypocalcemia, autosomal dominant, with Bartter syndrome (OMIM: )
- OMIM:601199 : Epilepsy, idiopathic generalized, susceptibility to, 8 (OMIM:612899 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | CaSR | Inference |  |  |  |  |  | Prediction | 22778254

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | CaSR | Co-immunofluorescence staining | Mouse submandibular gland (SMG) ductal tissue section |  |  |  |  |  | 22778254
TRPC3 |  | CaSR | Co-immunoprecipitation | Mouse submandibular gland (SMG) ductal cell lysates |  |  |  |  |  | 22778254

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPC3 |  | CaSR | Cell surface biotinylation |  | Increase in plasma membrane level |  | 22778254

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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