# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# P2RX3 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (15)
- Disease (0)

Name: P2X purinoceptor 3 (P2RX3)
Official Symbol: P2RX3 provided by HGNC
Function:
Receptor for ATP that acts as a ligand-gated ion channel.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5024 | P56373 |  |  |  | 111063 | P56373 |  | hsa:5024 | 600843
Mouse | 228139 | Q3UR32 |  |  |  | 230717 | Q3UR32 |  | mmu:228139 |
Rat | 81739 | P49654 |  |  |  | 249611 | P49654 |  | rno:81739 |

PPI pairs:

TRPV1

Biological Process:

- GO:0048266 : behavioral response to pain
- GO:0007274 : neuromuscular synaptic transmission
- GO:0030432 : peristalsis
- GO:0010524 : positive regulation of calcium ion transport into cytosol
- GO:0050850 : positive regulation of calcium-mediated signaling
- GO:0051260 : protein homooligomerization
- GO:0019228 : regulation of action potential in neuron
- GO:0048167 : regulation of synaptic plasticity
- GO:0033198 : response to ATP
- GO:0009743 : response to carbohydrate stimulus
- GO:0009409 : response to cold
- GO:0009408 : response to heat
- GO:0001666 : response to hypoxia
- GO:0050909 : sensory perception of taste
- GO:0014832 : urinary bladder smooth muscle contraction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | P2RX3 | Inference |  |  |  |  |  | Prediction | 19223122

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | P2RX3 | Co-immunoprecipitation |  | HEK293 | Rat | Full-length | Human | Full-length | 19223122

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
To prevent spam comments, we use reCAPTCHA. Please type correct words into the following box.