# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# E-cadherin / TRP channels

- Basic Information
- External Database
- PPI pairs (2)
- Biological Process (28)
- Disease (5)

Name: Cadherin-1 (E-cadherin)
Official Symbol: CDH1 provided by HGNC
Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 999 | P12830 | DIP-477N | P12830 | MINT-119105 | 107434 | P12830 |  | hsa:999 | 192090
Mouse | 12550 | P09803 | DIP-29635N | P09803 | MINT-121804 | 198631 | P09803 |  | mmu:12550 |
Rat | 83502 | Q9R0T4 |  |  | MINT-4620160 | 249721 | Q9R0T4 |  | rno:83502 |

PPI pairs:

TRPV1 | TRPV4

Biological Process:

- GO:0034332 : adherens junction organization
- GO:0034329 : cell junction assembly
- GO:0006921 : cellular component disassembly involved in execution phase of apoptosis
- GO:0071230 : cellular response to amino acid stimulus
- GO:0071681 : cellular response to indole-3-methanol
- GO:0071285 : cellular response to lithium ion
- GO:0090102 : cochlea development
- GO:0007156 : homophilic cell adhesion
- GO:0022408 : negative regulation of cell-cell adhesion
- GO:0031175 : neuron projection development
- GO:0021983 : pituitary gland development
- GO:0042993 : positive regulation of transcription factor import into nucleus
- GO:0045893 : positive regulation of transcription, DNA-dependent
- GO:0051260 : protein homooligomerization
- GO:0072659 : protein localization to plasma membrane
- GO:0019538 : protein metabolic process
- GO:0060693 : regulation of branching involved in salivary gland morphogenesis
- GO:0043281 : regulation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0050776 : regulation of immune response
- GO:2000008 : regulation of protein localization to cell surface
- GO:0033561 : regulation of water loss via skin
- GO:0042493 : response to drug
- GO:0009636 : response to toxin
- GO:0060662 : salivary gland cavitation
- GO:0007605 : sensory perception of sound
- GO:0007416 : synapse assembly
- GO:0070830 : tight junction assembly
- GO:0001829 : trophectodermal cell differentiation

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:192090 : Endometrial carcinoma, somatic (OMIM:608089 )
- OMIM:192090 : Ovarian carcinoma, somatic (OMIM:167000 )
- OMIM:192090 : Breast cancer, lobular (OMIM:114480 )
- OMIM:192090 : Gastric cancer, familial diffuse, with or without cleft lip and/or palate (OMIM:137215 )
- OMIM:192090 : Prostate cancer, susceptibility to (OMIM:176807 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | E-cadherin | Affinity purification-mass spectrometry | Not used |  | Mouse | Dorsal root ganglion tissue | Lysates |  | 24036102
TRPV1 |  | E-cadherin | Inference |  |  |  |  |  | Prediction | 23345400
TRPV4 |  | E-cadherin | Inference |  |  |  |  |  | Prediction | 20413591

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | E-cadherin | Co-immunofluorescence staining | Rat SMG cell line (SMG-C6) |  |  |  |  |  | 23345400
TRPV1 |  | E-cadherin | Co-immunoprecipitation | Rat SMG cell line (SMG-C6) |  |  |  |  |  | 23345400
TRPV4 |  | E-cadherin | Co-immunoprecipitation | MDCK |  |  |  |  |  | 20413591
TRPV4 |  | E-cadherin | Co-immunoprecipitation | HEK |  |  |  |  |  | 22374181

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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