# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# PMCA2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (23)
- Disease (1)

Name: Plasma membrane calcium-transporting ATPase 2 (PMCA2)
Official Symbol: ATP2B2 provided by HGNC
Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 491 | Q01814 |  | Q01814 | MINT-470839 | 106981 | Q01814 |  | hsa:491 | 108733
Mouse | 11941 | Q9R0K7 |  | Q9R0K7 |  | 198250 | Q9R0K7 |  | mmu:11941 |
Rat | 24215 | P11506 |  | P11506 | MINT-471009 | 246403 | P11506 |  | rno:24215 |

PPI pairs:

TRPC3

Biological Process:

- GO:0006754 : ATP biosynthetic process
- GO:0060088 : auditory receptor cell stereocilium organization
- GO:0007596 : blood coagulation
- GO:0021707 : cerebellar granule cell differentiation
- GO:0021702 : cerebellar Purkinje cell differentiation
- GO:0046068 : cGMP metabolic process
- GO:0090102 : cochlea development
- GO:0051480 : cytosolic calcium ion homeostasis
- GO:0050910 : detection of mechanical stimulus involved in sensory perception of sound
- GO:0007595 : lactation
- GO:0040011 : locomotion
- GO:0007626 : locomotory behavior
- GO:0003407 : neural retina development
- GO:0050885 : neuromuscular process controlling balance
- GO:0030182 : neuron differentiation
- GO:0006996 : organelle organization
- GO:0045299 : otolith mineralization
- GO:0051928 : positive regulation of calcium ion transport
- GO:0008361 : regulation of cell size
- GO:0048167 : regulation of synaptic plasticity
- GO:0007605 : sensory perception of sound
- GO:0042428 : serotonin metabolic process
- GO:0050808 : synapse organization

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:108733 : Deafness, autosomal recessive 12, modifier of (OMIM:601386 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | PMCA2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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