# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Calbindin-D28K / TRP channels

- Basic Information
- External Database
- PPI pairs (2)
- Biological Process (9)
- Disease (0)

Name: Calbindin (Calbindin-D28K)
Official Symbol: CALB1 provided by HGNC
Function:
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 793 | P05937 | DIP-43886N | P05937 | MINT-2834520 | 107244 | P05937 |  | hsa:793 | 114050
Mouse | 12307 | P12658 |  |  | MINT-4238614 | 198449 | P12658 |  | mmu:12307 |
Rat | 83839 | P07171 |  |  | MINT-4586315 | 249865 | P07171 |  | rno:83839 |

PPI pairs:

TRPV5 | TRPV6

Biological Process:

- GO:0071310 : cellular response to organic substance
- GO:0007611 : learning or memory
- GO:0007626 : locomotory behavior
- GO:0072205 : metanephric collecting duct development
- GO:0072286 : metanephric connecting tubule development
- GO:0072221 : metanephric distal convoluted tubule development
- GO:0035502 : metanephric part of ureteric bud development
- GO:0048167 : regulation of synaptic plasticity
- GO:0010842 : retina layer formation

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV5 |  | Calbindin-D28K | Inference |  |  |  |  |  | Prediction | 16763551
TRPV6 |  | Calbindin-D28K | Inference |  |  |  |  |  | Prediction | 16763551

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPV5 |  | Calbindin-D28K | Fusion protein-pull down assay | Mouse | N-terminus | E. coli | Not specified | Full-length | In vitro translation | 16763551
TRPV5 |  | Calbindin-D28K | Fusion protein-pull down assay | Mouse | C-terminus | E. coli | Not specified | Full-length | In vitro translation | 16763551
TRPV6 |  | Calbindin-D28K | Fusion protein-pull down assay | Mouse | N-terminus | E. coli | Not specified | Full-length | In vitro translation | 16763551
TRPV6 |  | Calbindin-D28K | Fusion protein-pull down assay | Mouse | C-terminus | E. coli | Not specified | Full-length | In vitro translation | 16763551

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV5 |  | Calbindin-D28K | Co-immunofluorescence staining | Mouse kidney section |  |  |  |  |  | 16763551
TRPV5 |  | Calbindin-D28K | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not specified | Full-length | 16763551

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV5 |  | Calbindin-D28K | Patch clamp |  |  | Activation | 16763551

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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