# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# NMDAR2B / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (40)
- Disease (1)

Name: Glutamate receptor ionotropic, NMDA 2B (NMDAR2B)
Official Symbol: GRIN2B provided by HGNC
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 2904 | Q13224 | DIP-41002N | Q13224 | MINT-127466 | 109161 | Q13224 |  | hsa:2904 | 138252
Mouse | 14812 | Q01097 | DIP-31568N | Q01097 | MINT-135847 | 200069 | Q01097 |  | mmu:14812 |
Rat | 24410 | Q00960 | DIP-33702N | Q00960 | MINT-104014 | 246575 | Q00960 |  | rno:24410 |

PPI pairs:

TRPV1

Biological Process:

- GO:0008306 : associative learning
- GO:0001662 : behavioral fear response
- GO:0048266 : behavioral response to pain
- GO:0071230 : cellular response to amino acid stimulus
- GO:0071359 : cellular response to dsRNA
- GO:0071363 : cellular response to growth factor stimulus
- GO:0071396 : cellular response to lipid
- GO:0010350 : cellular response to magnesium starvation
- GO:0071287 : cellular response to manganese ion
- GO:0021987 : cerebral cortex development
- GO:0050966 : detection of mechanical stimulus involved in sensory perception of pain
- GO:0021766 : hippocampus development
- GO:0001701 : in utero embryonic development
- GO:0007611 : learning or memory
- GO:0007616 : long-term memory
- GO:0010942 : positive regulation of cell death
- GO:0014049 : positive regulation of glutamate secretion
- GO:0050806 : positive regulation of synaptic transmission
- GO:0043113 : receptor clustering
- GO:0001508 : regulation of action potential
- GO:0060079 : regulation of excitatory postsynaptic membrane potential
- GO:0048169 : regulation of long-term neuronal synaptic plasticity
- GO:0043408 : regulation of MAPK cascade
- GO:0001975 : response to amphetamine
- GO:0051592 : response to calcium ion
- GO:0009743 : response to carbohydrate stimulus
- GO:0042220 : response to cocaine
- GO:0034097 : response to cytokine stimulus
- GO:0051602 : response to electrical stimulus
- GO:0045471 : response to ethanol
- GO:0060992 : response to fungicide
- GO:0060416 : response to growth hormone stimulus
- GO:0032026 : response to magnesium ion
- GO:0051597 : response to methylmercury
- GO:0051707 : response to other organism
- GO:0048511 : rhythmic process
- GO:0007423 : sensory organ development
- GO:0001964 : startle response
- GO:0001967 : suckling behavior
- GO:0007268 : synaptic transmission

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:138252 : Mental retardation, autosomal dominant 6 (OMIM:613970 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | NMDAR2B | Inference |  |  |  |  |  | Prediction | 22609428

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV1 |  | NMDAR2B | Co-immunoprecipitation | Rat trigeminal ganglia lysates |  |  |  |  |  | 22609428

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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