# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# NKX2.2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (20)
- Disease (0)

Name: Homeobox protein Nkx-2.2 (NKX2.2)
Official Symbol: NKX2-2 provided by HGNC
Function:
Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4821 | O95096 | DIP-58072N |  | UNK-5367814 | 110886 | O95096 |  | hsa:4821 | 604612
Mouse | 18088 | P42586 |  |  | MINT-4103861 | 201776 | P42586 |  | mmu:18088 |
Rat | 366214 | D3ZDQ2 |  |  |  | 265801 |  |  | rno:366214 |

PPI pairs:

TRPV1

Biological Process:

- GO:0048708 : astrocyte differentiation
- GO:0007420 : brain development
- GO:0048565 : digestive tract development
- GO:0031018 : endocrine pancreas development
- GO:0045665 : negative regulation of neuron differentiation
- GO:0048665 : neuron fate specification
- GO:0014003 : oligodendrocyte development
- GO:0003326 : pancreatic A cell fate commitment
- GO:0003329 : pancreatic PP cell fate commitment
- GO:0045666 : positive regulation of neuron differentiation
- GO:0048714 : positive regulation of oligodendrocyte differentiation
- GO:0051091 : positive regulation of sequence-specific DNA binding transcription factor activity
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0007224 : smoothened signaling pathway
- GO:0021522 : spinal cord motor neuron differentiation
- GO:0021530 : spinal cord oligodendrocyte cell fate specification
- GO:0006351 : transcription, DNA-dependent
- GO:0003323 : type B pancreatic cell development
- GO:0003327 : type B pancreatic cell fate commitment
- GO:0060580 : ventral spinal cord interneuron fate determination

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV1 |  | NKX2.2 | Yeast two-hybrid | Rat | 1-432 | Human | Fetal brain | cDNA library |  | 17074976

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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