# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Caspase-1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (20)
- Disease (0)

Name: Caspase-1 (Caspase-1)
Official Symbol: CASP1 provided by HGNC
Function:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 834 | P29466 | DIP-175N | P29466 | MINT-201196 | 107284 | P29466 |  | hsa:834 | 147678
Mouse | 12362 | P29452 | DIP-34659N | P29452 |  |  | P29452 |  | mmu:12362 |
Rat |  | P43527 | DIP-29840N |  |  |  | P43527 |  |  |

PPI pairs:

TRPC1

Biological Process:

- GO:0006919 : activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0006915 : apoptotic process
- GO:0071260 : cellular response to mechanical stimulus
- GO:0071310 : cellular response to organic substance
- GO:0097194 : execution phase of apoptosis
- GO:0045087 : innate immune response
- GO:0032611 : interleukin-1 beta production
- GO:0060081 : membrane hyperpolarization
- GO:0051882 : mitochondrial depolarization
- GO:0035872 : nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB signaling
- GO:0050717 : positive regulation of interleukin-1 alpha secretion
- GO:0050718 : positive regulation of interleukin-1 beta secretion
- GO:0006508 : proteolysis
- GO:0070269 : pyroptosis
- GO:0050727 : regulation of inflammatory response
- GO:0033198 : response to ATP
- GO:0001666 : response to hypoxia
- GO:0032496 : response to lipopolysaccharide
- GO:0007165 : signal transduction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | Caspase-1 | Speculation |  |  |  |  |  | Prediction | 24630989

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | Caspase-1 | Co-immunoprecipitation |  | HEK293T | Not specified | Full-length | Not specified | Full-length | 24630989

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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