# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# KRAS / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (26)
- Disease (8)

Name: GTPase KRas (KRAS)
Official Symbol: KRAS provided by HGNC
Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 3845 | P01116 | DIP-33951N | P01116 | MINT-131580 | 110043 | P01116 |  | hsa:3845 | 190070
Mouse | 16653 | P32883 | DIP-29362N | P32883 | MINT-216577 | 201012 | P32883 |  | mmu:16653 |
Rat | 24525 | P08644 |  |  | MINT-4586724 | 246680 | P08644 |  | rno:24525 |

PPI pairs:

TRPP1

Biological Process:

- GO:0030036 : actin cytoskeleton organization
- GO:0000186 : activation of MAPKK activity
- GO:0007411 : axon guidance
- GO:0007596 : blood coagulation
- GO:0019221 : cytokine-mediated signaling pathway
- GO:0007173 : epidermal growth factor receptor signaling pathway
- GO:0008543 : fibroblast growth factor receptor signaling pathway
- GO:0008286 : insulin receptor signaling pathway
- GO:0050900 : leukocyte migration
- GO:0000165 : MAPK cascade
- GO:0043524 : negative regulation of neuron apoptotic process
- GO:0048011 : nerve growth factor receptor signaling pathway
- GO:0008284 : positive regulation of cell proliferation
- GO:0010628 : positive regulation of gene expression
- GO:0043406 : positive regulation of MAP kinase activity
- GO:0051092 : positive regulation of NF-kappaB transcription factor activity
- GO:0051000 : positive regulation of nitric-oxide synthase activity
- GO:0035022 : positive regulation of Rac protein signal transduction
- GO:0007265 : Ras protein signal transduction
- GO:0048169 : regulation of long-term neuronal synaptic plasticity
- GO:0032228 : regulation of synaptic transmission, GABAergic
- GO:0051384 : response to glucocorticoid stimulus
- GO:0051385 : response to mineralocorticoid stimulus
- GO:0035176 : social behavior
- GO:0051146 : striated muscle cell differentiation
- GO:0008542 : visual learning

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:190070 : Lung cancer (OMIM:211980 )
- OMIM:190070 : Bladder cancer (OMIM:109800 )
- OMIM:190070 : Breast cancer, somatic (OMIM:114480 )
- OMIM:190070 : Pancreatic carcinoma, somatic (OMIM:260350 )
- OMIM:190070 : Gastric cancer (OMIM:137215 )
- OMIM:190070 : Leukemia, acute myelogenous (OMIM: )
- OMIM:190070 : Noonan syndrome 3 (OMIM:609942 )
- OMIM:190070 : Cardiofaciocutaneous syndrome (OMIM:115150 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | KRAS | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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