# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# AQP-4 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (6)
- Disease (0)

Name: Aquaporin-4 (AQP-4)
Official Symbol: AQP4 provided by HGNC
Function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 361 | P55087 | DIP-48842N |  | MINT-3020799 | 106857 | P55087 |  | hsa:361 |
Mouse | 11829 | P55088 |  |  | MINT-4088102 | 198173 | P55088 |  | mmu:11829 |
Rat | 25293 | P47863 |  |  | MINT-5027530 | 247332 | P47863 |  | rno:25293 |

PPI pairs:

TRPV4

Biological Process:

- GO:0071346 : cellular response to interferon-gamma
- GO:0007588 : excretion
- GO:0050891 : multicellular organismal water homeostasis
- GO:0007399 : nervous system development
- GO:0070295 : renal water absorption
- GO:0007605 : sensory perception of sound

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV4 |  | AQP-4 | Inference |  |  |  |  |  | Prediction | 21262839

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV4 |  | AQP-4 | Co-immunofluorescence staining | Adult rat brain section |  |  |  |  |  | 21262839
TRPV4 |  | AQP-4 | Co-immunoprecipitation | Adult rat brain lysates |  |  |  |  |  | 21262839
TRPV4 |  | AQP-4 | Co-immunoprecipitation |  | DI TNC1 | Human | Full-length | Rat | Full-length | 21262839

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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