# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPP1 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (116)
- Biological Process (41)
- Disease (1)

Name: Polycystin-2 (TRPP1)
Official Symbol: PKD2 provided by HGNC
Function:
Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). Functions as a calcium permeable cation channel.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 5311 | Q13563 | DIP-47455N |  | MINT-6618167 | 111328 | Q13563 | 504 | hsa:5311 | 173910
Mouse | 18764 | O35245 |  |  |  | 202205 | O35245 |  | mmu:18764 |
Rat | 498328 | D4A5F1 |  |  |  | 269638 |  |  | rno:498328 |

PPI pairs:

80K-H | ABHD12 | ATP13A1 | BAG2 | BRI3BP | CD2AP | CDKAL1 | CISD2
Calnexin | Cullin-1 | DHRS7B | DIAP1/DRF1 | EGFR | EPHA2 | ERLIN2 | FAF2
Filamin-A | H2-D1 | H2-K1 | HAX-1 | HDAC6 | HERP | HSP40/DNAJA1 | ID2
IFIT1 | IFT57 | IP3R1 | IP3R3 | KIF3A | KIF3B | KIM1/TIM1 | KRAS
LAP2/TMPO | LETMD1 | MGST1 | NEK8 | Numb | Nup155 | PACS-1 | PACS-2
PDIA3/GRP58 | PERK | PGAM5 | PIGEA-14/CBY1 | PKA | PKD1/Polycystin-1 | PKD1L1/Polycystin-1L1 | PKHD1/FPC
PLCƣ2 | PSMD7 | PTP1B | Paraoxonase 3 | Pericentrin | Piezo1 | RAB12 | RAB14
RAB18 | RAB21 | RAB7 | RAD50 | RCHY1/PIRH2 | RP2 | RTP4 | Ribophorin I
Ribophorin II | RyR2 | SEC22B | SEC61B | SERCA2 | SGPL1 | SKP1 | SRPRB
SSFA2 | ST7 | SUN3 | Syntaxin5 | TAP1 | TAP2 | TAZ/WWTR1 | TBL2
TFRC | TMEM120a | TMEM209 | TMEM48/NDC1 | TMEM59 | TOR1AIP1/LAB1B | TRIM59 | TRPC1
TRPC3 | TRPC4 | TRPC7 | TRPV4 | TTC35 | TYW1 | Tapasin | Tropomyosin 1
Troponin I 1 | Troponin I 2 | Troponin I 3 | UBC | UHRF1 | USE1 | VAMPA | VAMPB
VDAC3 | VRK2 | VTI1B | Viperin | eIF2ơ | p97/VCP | ơ-actinin | ơ-actinin-1
ơ-actinin-2 | Ƣ-Trcp1 | Ƣ-Trcp2 | ƣ-adaptin

Biological Process:

- GO:0035904 : aorta development
- GO:0001658 : branching involved in ureteric bud morphogenesis
- GO:0007050 : cell cycle arrest
- GO:0071498 : cellular response to fluid shear stress
- GO:0071464 : cellular response to hydrostatic pressure
- GO:0071470 : cellular response to osmotic stress
- GO:0034614 : cellular response to reactive oxygen species
- GO:0051298 : centrosome duplication
- GO:0042994 : cytoplasmic sequestering of transcription factor
- GO:0050982 : detection of mechanical stimulus
- GO:0003127 : detection of nodal flow
- GO:0061371 : determination of heart left/right asymmetry
- GO:0001892 : embryonic placenta development
- GO:0007507 : heart development
- GO:0007259 : JAK-STAT cascade
- GO:0001889 : liver development
- GO:0072177 : mesonephric duct development
- GO:0072218 : metanephric ascending thin limb development
- GO:0072214 : metanephric cortex development
- GO:0072219 : metanephric cortical collecting duct development
- GO:0072235 : metanephric distal tubule development
- GO:0072075 : metanephric mesenchyme development
- GO:0035502 : metanephric part of ureteric bud development
- GO:0072284 : metanephric S-shaped body morphogenesis
- GO:0072208 : metanephric smooth muscle tissue development
- GO:0008285 : negative regulation of cell proliferation
- GO:2000134 : negative regulation of G1/S transition of mitotic cell cycle
- GO:0060315 : negative regulation of ryanodine-sensitive calcium-release channel activity
- GO:0021915 : neural tube development
- GO:0060674 : placenta blood vessel development
- GO:0071158 : positive regulation of cell cycle arrest
- GO:0031659 : positive regulation of cyclin-dependent protein kinase activity involved in G1/S
- GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
- GO:0045429 : positive regulation of nitric oxide biosynthetic process
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0090279 : regulation of calcium ion import
- GO:0030814 : regulation of cAMP metabolic process
- GO:0051209 : release of sequestered calcium ion into cytosol
- GO:0061441 : renal artery morphogenesis
- GO:0061333 : renal tubule morphogenesis
- GO:0021510 : spinal cord development

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:173910 : Polycystic kidney disease 2 (OMIM:613095 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | 80K-H | Inference |  |  |  |  |  | Prediction | 19801576
TRPP1 |  | ABHD12 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | ATP13A1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | BAG2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | BRI3BP | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Calnexin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | CD2AP | Yeast two-hybrid | Mouse | 680-968 | Mouse | Embryonic | cDNA library |  | 10913159
TRPP1 |  | CDKAL1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | CISD2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Cullin-1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | cullin-1 | Inference |  |  |  |  |  | Prediction | 17636028
TRPP1 |  | DHRS7B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | DIAP1/DRF1 | Yeast two-hybrid | Human | 851-968 | Mouse | Embryonic | cDNA library |  | 15123714
TRPP1 |  | EGFR | Inference |  |  |  |  |  | Prediction | 16135816
TRPP1 |  | eIF2ơ | Inference |  |  |  |  |  | Prediction | 18664456
TRPP1 |  | EPHA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | ERLIN2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | FAF2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Filamin-A | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | ƣ-adaptin | Inference |  |  |  |  |  | Prediction | 15692563
TRPP1 |  | Ƣ-Trcp1 | Inference |  |  |  |  |  | Prediction | 17636028
TRPP1 |  | Ƣ-Trcp2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Ƣ-Trcp2 | Inference |  |  |  |  |  | Prediction | 17636028
TRPP1 |  | H2-D1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | H2-K1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Mouse | Embryonic | cDNA library |  | 10760273
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Human | Kidney | cDNA library |  | 10760273
TRPP1 |  | HDAC6 | Inference |  |  |  |  |  | Prediction | 24459142
TRPP1 |  | HERP | Inference |  |  |  |  |  | Prediction | 18178578
TRPP1 |  | HSP40/DNAJA1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | ID2 | Yeast two-hybrid | Human | 679-968 | Human | Fetal kidney | cDNA library |  | 16311606
TRPP1 |  | IFIT1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | IFT57 | Inference |  |  |  |  |  | Prediction | 15337773
TRPP1 |  | IP3R1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | IP3R1 | Inference |  |  |  |  |  | Prediction | 16223735
TRPP1 |  | IP3R3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | KIF3A | Inference |  |  |  |  |  | Prediction | 16950792
TRPP1 |  | KIF3B | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library |  | 16950792
TRPP1 |  | KIF3B | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library |  | 17008358
TRPP1 |  | KIM1/TIM1 | Inference |  |  |  |  |  | Prediction | 18273441
TRPP1 |  | KRAS | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | LAP2/TMPO | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | LETMD1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | MGST1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | NEK8 | Inference |  |  |  |  |  | Prediction | 18235101
TRPP1 |  | Numb | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Nup155 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | ơ-actinin | Inference |  |  |  |  |  | Prediction | 15843396
TRPP1 |  | ơ-actinin-1 | Inference |  |  |  |  |  | Prediction | 15843396
TRPP1 |  | ơ-actinin-2 | Yeast two-hybrid | Human | 1-215 | Human | Heart | cDNA library |  | 15843396
TRPP1 |  | p97/VCP | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | p97/VCP | Inference |  |  |  |  |  | Prediction | 18178578
TRPP1 |  | PACS-1 | Inference |  |  |  |  |  | Prediction | 15692563
TRPP1 |  | PACS-2 | Inference |  |  |  |  |  | Prediction | 15692563
TRPP1 |  | Paraoxonase 3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | PDIA3/GRP58 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Pericentrin | Inference |  |  |  |  |  | Prediction | 15337773
TRPP1 |  | PERK | Inference |  |  |  |  |  | Prediction | 18664456
TRPP1 |  | PGAM5 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Piezo1 | Inference |  |  |  |  |  | Prediction | 24157948
TRPP1 |  | PIGEA-14/CBY1 | Yeast two-hybrid | Human | 680-968 | Human | Kidney | cDNA library |  | 15194699
TRPP1 |  | PKD1/Polycystin-1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | PKD1/Polycystin-1 | Inference |  |  |  |  |  | Prediction | 9171830
TRPP1 |  | PKD1L1/Polycystin-1L1 | Inference |  |  |  |  |  | Prediction | 21307093
TRPP1 |  | PKHD1/FPC | Inference |  |  |  |  |  | Prediction | 17008358
TRPP1 |  | PLCƣ2 | Inference |  |  |  |  |  | Prediction | 16135816
TRPP1 |  | PSMD7 | Inference |  |  |  |  |  | Prediction | 18178578
TRPP1 |  | PTP1B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RAB12 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RAB14 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RAB18 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RAB21 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RAB7 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RAD50 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RCHY1/PIRH2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Ribophorin I | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Ribophorin II | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RP2 | Inference |  |  |  |  |  | Prediction | 20729296
TRPP1 |  | RTP4 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | RyR2 | Inference |  |  |  |  |  | Prediction | 17404231
TRPP1 |  | SEC22B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SEC61B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SERCA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SGPL1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SKP1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SRPRB | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SSFA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | ST7 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | SUN3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Syntaxin5 | Yeast two-hybrid | Human | 3-213 | Mouse | Embryonic | cDNA library |  | 18836075
TRPP1 |  | TAP1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TAP2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Tapasin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TAZ/WWTR1 | Inference |  |  |  |  |  | Prediction | 17636028
TRPP1 |  | TBL2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TFRC | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TMEM120a | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TMEM209 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TMEM48/NDC1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TMEM59 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TOR1AIP1/LAB1B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TRIM59 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Tropomyosin 1 | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library |  | 12527301
TRPP1 |  | Troponin I 1 | Inference |  |  |  |  |  | Prediction | 12525172
TRPP1 |  | Troponin I 2 | Inference |  |  |  |  |  | Prediction | 12525172
TRPP1 |  | Troponin I 3 | Yeast two-hybrid | Human | 682-968 | Human | Heart | cDNA library |  | 12525172
TRPP1 |  | TRPC1 | Inference |  |  |  |  |  | Prediction | 10097141
TRPP1 |  | TRPC3 | Inference |  |  |  |  |  | Prediction | 19812035
TRPP1 |  | TRPC4 | Inference |  |  |  |  |  | Prediction | 18256307
TRPP1 |  | TRPC7 | Inference |  |  |  |  |  | Prediction | 19812035
TRPP1 |  | TRPV4 | Inference |  |  |  |  |  | Prediction | 18695040
TRPP1 |  | TTC35 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | TYW1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | UBC | Inference |  |  |  |  |  | Prediction | 18178578
TRPP1 |  | UHRF1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | USE1 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | VAMPA | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | VAMPB | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | VDAC3 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | Viperin | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | VRK2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844
TRPP1 |  | VTI1B | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPP1 |  | CD2AP | Fusion protein-pull down assay | Mouse | 747-968 | E. coli | Mouse | 331-637 | E. coli | 10913159
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Yeast | Mouse | 94-280 | Yeast | 10760273
TRPP1 |  | ID2 | Yeast two-hybrid | Human | 679-968 | Yeast | Human | 1-134 | Yeast | 16311606
TRPP1 |  | KIF3A | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | In vitro translation | 16950792
TRPP1 |  | KIF3A | Yeast two-hybrid | Human | 682-968 | Yeast | Human | Full-length | Yeast | 16950792
TRPP1 |  | KIF3B | Fusion protein-pull down assay | Human | 1-215 | E. coli | Not used |  | Mouse inner medullary collecting duct cell lysates | 17008358
TRPP1 |  | KIF3B | Fusion protein-pull down assay | Human | 682-968 | E. coli | Not used |  | Mouse inner medullary collecting duct cell lysates | 17008358
TRPP1 |  | ơ-actinin-1 | Fusion protein-pull down assay | Human | 1-215 | E. coli | Chicken | Not specified | Not specified | 15843396
TRPP1 |  | ơ-actinin-1 | Fusion protein-pull down assay | Human | 821-968 | E. coli | Chicken | Not specified | Not specified | 15843396
TRPP1 |  | ơ-actinin-2 | Fusion protein-pull down assay | Human | 1-215 | E. coli | Chicken | Not specified | Not specified | 15843396
TRPP1 |  | ơ-actinin-2 | Fusion protein-pull down assay | Human | 821-968 | E. coli | Chicken | Not specified | Not specified | 15843396
TRPP1 |  | PACS-1 | Fusion protein-pull down assay | Human | Full-length | HEK293T lysates | Human | Full-length | Not specified | 15692563
TRPP1 |  | PACS-1 | Fusion protein-pull down assay | Not used |  | Mouse kidney tissue lysates | Human | Full-length | Not specified | 15692563
TRPP1 |  | PACS-2 | Fusion protein-pull down assay | Human | Full-length | HEK293T lysates | Human | Full-length | Not specified | 15692563
TRPP1 |  | PKD1/Polycystin-1 | Yeast two-hybrid | Human | 680-968 | Yeast | Human | 1114-1339 | Yeast | 9192675
TRPP1 |  | PKD1/Polycystin-1 | Yeast two-hybrid | Human | 687-968 | Yeast | Human | 4088-4302 | Yeast | 9171830
TRPP1 |  | RyR2 | Fusion protein-pull down assay | Human | 1-703 | MDCK lysates | Not used |  | Mouse cardiac tissue microsome | 17404231
TRPP1 |  | Syntaxin5 | Fusion protein-pull down assay | Human | 3-213 | E. coli | Mouse | Full-length | Not specified | 18836075
TRPP1 |  | TAZ/WWTR1 | Fusion protein-pull down assay | Mouse | 678-966 | E. coli | Mouse | 1-395 | HEK293 lysates | 17636028
TRPP1 |  | Tropomyosin 1 | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | E. coli | 12527301
TRPP1 |  | Troponin I 3 | Fusion protein-pull down assay | Human | 682-968 | E. coli | Human | Full-length | E. coli | 12525172
TRPP1 |  | TRPC1 | Fusion protein-pull down assay | Human | 680-968 | In vitro translation | Human | 662-750 | E. coli | 10097141

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | 80K-H | Co-immunofluorescence staining |  | HeLa | Human | Full-length | Not used |  | 19801576
TRPP1 |  | 80K-H | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 19801576
TRPP1 |  | CD2AP | Co-immunofluorescence staining | M-1 cell |  |  |  |  |  | 10913159
TRPP1 |  | CD2AP | Co-immunofluorescence staining |  | LLC-PK1 | Human | Full-length | Mouse | Full-length | 10913159
TRPP1 |  | CD2AP | Co-immunoprecipitation | M-1 cell |  |  |  |  |  | 10913159
TRPP1 |  | cullin-1 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 17636028
TRPP1 |  | DIAP1/DRF1 | Co-immunofluorescence staining | LLC-PK1 |  |  |  |  |  | 15123714
TRPP1 |  | DIAP1/DRF1 | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 15123714
TRPP1 |  | EGFR | Co-immunofluorescence staining | LLC-PK1 |  |  |  |  |  | 16135816
TRPP1 |  | EGFR | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 16135816
TRPP1 |  | eIF2ơ | Co-immunofluorescence staining |  | HEK293T | Human | Full-length | Not used |  | 18664456
TRPP1 |  | eIF2ơ | Co-immunoprecipitation | Mouse Inner medullary collecting duct |  |  |  |  |  | 18664456
TRPP1 |  | Filamin-A | Co-immunoprecipitation | COS-7 |  |  |  |  |  | 19879844
TRPP1 |  | ƣ-adaptin | Co-immunoprecipitation | COS M6 kidney cell |  |  |  |  |  | 15692563
TRPP1 |  | Ƣ-Trcp1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028
TRPP1 |  | Ƣ-Trcp2 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028
TRPP1 |  | HAX-1 | Co-immunofluorescence staining |  | HeLa | Human | Full-length | Mouse | Full-length | 10760273
TRPP1 |  | HAX-1 | Co-immunoprecipitation |  | HeLa | Human | Full-length | Mouse | Full-length | 10760273
TRPP1 |  | HDAC6 | Co-immunoprecipitation | MDCK |  |  |  |  |  | 24459142
TRPP1 |  | HERP | Co-immunoprecipitation |  | HeLa | Human | Full-length | Mouse | Full-length | 18178578
TRPP1 |  | HERP | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Mouse | Full-length | 19801576
TRPP1 |  | ID2 | Co-immunofluorescence staining |  | HEK293T | Human | Full-length | Not used |  | 16311606
TRPP1 |  | ID2 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Not used |  | 16311606
TRPP1 |  | IFT57 | Co-immunoprecipitation | Tg737 Mouse 488 epithelial cell |  |  |  |  |  | 15337773
TRPP1 |  | IP3R1 | Co-immunofluorescence staining |  | LLC-PK1 | Human | Full-length | Not used |  | 20375013
TRPP1 |  | IP3R1 | Co-immunoprecipitation |  | COS-7 | Human | Full-length | Not used |  | 16223735
TRPP1 |  | IP3R1 | Co-immunoprecipitation |  | Xenopus oocyte | Human | 1-741 | Not used |  | 16223735
TRPP1 |  | IP3R1 | Co-immunoprecipitation |  | Xenopus oocyte | Human | Full-length | Not used |  | 16223735
TRPP1 |  | IP3R1 | Co-immunoprecipitation |  | LLC-PK1 | Human | Full-length | Not used |  | 20375013
TRPP1 |  | IP3R3 | Co-immunofluorescence staining |  | LLC-PK1 | Human | Full-length | Not used |  | 20375013
TRPP1 |  | IP3R3 | Co-immunoprecipitation |  | LLC-PK1 | Human | Full-length | Not used |  | 20375013
TRPP1 |  | KIF3A | Co-immunofluorescence staining | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 16950792
TRPP1 |  | KIF3A | Co-immunofluorescence staining | MDCK |  |  |  |  |  | 16950792
TRPP1 |  | KIF3A | Co-immunofluorescence staining | LLC-PK1 |  |  |  |  |  | 16950792
TRPP1 |  | KIF3A | Co-immunoprecipitation | MDCK |  |  |  |  |  | 17283055
TRPP1 |  | KIF3B | Co-immunofluorescence staining | Mouse inner medullary collecting duct cell |  |  |  |  |  | 17008358
TRPP1 |  | KIF3B | Co-immunoprecipitation | MDCK |  |  |  |  |  | 17008358
TRPP1 |  | KIF3B | Co-immunoprecipitation | Mouse inner medullary collecting duct cell |  |  |  |  |  | 17008358
TRPP1 |  | KIF3B | Co-immunoprecipitation | Human kidney lysates |  |  |  |  |  | 17008358
TRPP1 |  | KIM1/TIM1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 18273441
TRPP1 |  | NEK8 | Co-immunofluorescence staining | Mouse kidney section |  |  |  |  |  | 18235101
TRPP1 |  | NEK8 | Co-immunoprecipitation | Mouse kidney tissue |  |  |  |  |  | 18235101
TRPP1 |  | NEK8 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 18235101
TRPP1 |  | ơ-actinin-1 | Co-immunofluorescence staining | NIH-3T3 |  |  |  |  |  | 15843396
TRPP1 |  | ơ-actinin-1 | Co-immunofluorescence staining | MDCK |  |  |  |  |  | 15843396
TRPP1 |  | ơ-actinin-1 | Co-immunofluorescence staining | Mouse inner medullary collecting duct cell |  |  |  |  |  | 15843396
TRPP1 |  | ơ-actinin-1 | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 15843396
TRPP1 |  | ơ-actinin-1 | Co-immunoprecipitation | MDCK |  |  |  |  |  | 15843396
TRPP1 |  | ơ-actinin-1 | Co-immunoprecipitation | Rat kidney tissue |  |  |  |  |  | 15843396
TRPP1 |  | ơ-actinin-2 | Co-immunoprecipitation | Rat heart tissue |  |  |  |  |  | 15843396
TRPP1 |  | p97/VCP | Co-immunofluorescence staining |  | MDCK | Human | Full-length | Not used |  | 18178578
TRPP1 |  | p97/VCP | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 18178578
TRPP1 |  | PACS-1 | Co-immunoprecipitation | COS M6 kidney cell |  |  |  |  |  | 15692563
TRPP1 |  | PACS-2 | Co-immunoprecipitation | COS M6 kidney cell |  |  |  |  |  | 15692563
TRPP1 |  | Pericentrin | Co-immunofluorescence staining | RPE1 |  |  |  |  |  | 15337773
TRPP1 |  | Pericentrin | Co-immunoprecipitation | RPE1 |  |  |  |  |  | 15337773
TRPP1 |  | PERK | Co-immunoprecipitation | Mouse Inner medullary collecting duct |  |  |  |  |  | 18664456
TRPP1 |  | PERK | Co-immunoprecipitation |  | HEK293T | Not used |  | Mouse | Full-length | 18664456
TRPP1 |  | PERK | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Not used |  | 18664456
TRPP1 |  | Piezo1 | Co-immunoprecipitation |  | COS | Mouse | Full-length | Not specified | Full-length | 24157948
TRPP1 |  | PIGEA-14/CBY1 | Co-immunofluorescence staining |  | HeLa | Human | Full-length | Human | Full-length | 15194699
TRPP1 |  | PIGEA-14/CBY1 | Co-immunoprecipitation |  | LLC-PK1 | Human | Full-length | Human | Full-length | 15194699
TRPP1 |  | PKD1/Polycystin-1 | Co-immunofluorescence staining |  | CHO | Human | Full-length | Human | Full-length | 15060061
TRPP1 |  | PKD1/Polycystin-1 | Co-immunofluorescence staining |  | CHO | Human | Full-length | Human | Full-length | 11140688
TRPP1 |  | PKD1/Polycystin-1 | Co-immunofluorescence staining |  | PKD2-/- transgenic mouse kidney tissue | Human | Full-length | Mouse | Full-length | 12840011
TRPP1 |  | PKD1/Polycystin-1 | Co-immunofluorescence staining | Mouse vascular smooth muscle cell |  |  |  |  |  | 12937304
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation | COS-1 |  |  |  |  |  | 11901144
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation | Human kidney lysates |  |  |  |  |  | 11901144
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation |  | HEK293T | Human | 680-968 | Human | 1114-1339 | 9192675
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 23390129
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation |  | CHO | Human | Full-length | Human | Full-length | 11140688
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation |  | COS-7 | Human | Full-length | Mouse | 4182-4293 | 12840011
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation | Mouse vascular smooth muscle cell |  |  |  |  |  | 12937304
TRPP1 |  | PKD1L1/Polycystin-1L1 | Co-immunofluorescence staining |  | mIMCD-3 | Mouse | Full-length | Mouse | Full-length | 21307093
TRPP1 |  | PKD1L1/Polycystin-1L1 | Co-immunoprecipitation |  | HEK293T | Mouse | Full-length | Mouse | Full-length | 21307093
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | Mouse kidney tissue |  |  |  |  |  | 18235088
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | 3872-4074 | 18235088
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | Mouse inner medulla collecting duct cell |  |  |  |  |  | 17008358
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | Mouse kidney tissue |  |  |  |  |  | 17283055
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | MDCK |  |  |  |  |  | 17283055
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation |  | HEK293 | Human | 1-215 | Human | 3882-4074 | 18782757
TRPP1 |  | PLCƣ2 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Not specified | Full-length | 16135816
TRPP1 |  | PSMD7 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 18178578
TRPP1 |  | RP2 | Co-immunoprecipitation | Bovine retinal extract |  |  |  |  |  | 20729296
TRPP1 |  | RP2 | Co-immunoprecipitation |  | MDCK | Not used |  | Human | Full-length | 20729296
TRPP1 |  | RyR2 | Co-immunoprecipitation | Mouse heart tissue |  |  |  |  |  | 17404231
TRPP1 |  | Syntaxin5 | Co-immunofluorescence staining |  | LLC-PK1 | Human | Full-length | Mouse | Full-length | 18836075
TRPP1 |  | Syntaxin5 | Co-immunoprecipitation |  | LLC-PK1 | Human | Full-length | Mouse | Full-length | 18836075
TRPP1 |  | TAZ/WWTR1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 17636028
TRPP1 |  | TAZ/WWTR1 | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 17636028
TRPP1 |  | Tropomyosin 1 | Co-immunofluorescence staining |  | NIH-3T3 | Human | Full-length | Human | Full-length | 12527301
TRPP1 |  | Tropomyosin 1 | Co-immunoprecipitation |  | NIH-3T3 | Human | Full-length | Human | Full-length | 12527301
TRPP1 |  | Tropomyosin 1 | Co-immunoprecipitation |  | Xenopus oocyte | Human | Full-length | Human | Full-length | 12527301
TRPP1 |  | Tropomyosin 1 | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 12527301
TRPP1 |  | Tropomyosin 1 | Co-immunoprecipitation | Human kidney tissue |  |  |  |  |  | 12527301
TRPP1 |  | Troponin I 1 | Co-immunoprecipitation |  | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172
TRPP1 |  | Troponin I 1 | Co-immunoprecipitation |  | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172
TRPP1 |  | Troponin I 2 | Co-immunoprecipitation |  | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172
TRPP1 |  | Troponin I 2 | Co-immunoprecipitation |  | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172
TRPP1 |  | Troponin I 3 | Co-immunoprecipitation |  | NIH-3T3 | Human | Full-length | Human | Full-length | 12525172
TRPP1 |  | Troponin I 3 | Co-immunoprecipitation |  | Xenopus oocyte | Human | Full-length | Human | Full-length | 12525172
TRPP1 |  | Troponin I 3 | Co-immunoprecipitation | Human heart tissue |  |  |  |  |  | 12525172
TRPP1 |  | TRPC1 | Co-immunofluorescence staining |  | HEK293 tsA 201 | Human | Full-length | Human | Full-length | 19850920
TRPP1 |  | TRPC1 | Co-immunofluorescence staining | mIMCD-3 |  |  |  |  |  | 18323855
TRPP1 |  | TRPC1 | Co-immunofluorescence staining |  | HEK293T | Human | Full-length | Human | Full-length | 10097141
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | HEK293T | Not specified | Not specified | Human | Full-length | 14530267
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | Human glomerular mesangial cell | Not used |  | Human | Full-length | 18256307
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Mouse | Full-length | 19812035
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | HEK293 tsA 201 | Human | Full-length | Human | Full-length | 19850920
TRPP1 |  | TRPC1 | Co-immunoprecipitation | Rat kidney tissue |  |  |  |  |  | 18323855
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | HEK293 tsA 201 | Human | Full-length | Human | Full-length | 20682256
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | Rat mesenteric artery endothelial cell | Human | Full-length | Human | Full-length | 25114176
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 25114176
TRPP1 |  | TRPC1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 10097141
TRPP1 |  | TRPC1 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Human | Full-length | 25114176
TRPP1 |  | TRPC3 | Co-immunofluorescence staining |  | LLC-PK1 | Human | 1-697 | Not used |  | 19812035
TRPP1 |  | TRPC3 | Co-immunoprecipitation |  | HEK293 | Human | 1-697 | Mouse | Full-length | 19812035
TRPP1 |  | TRPC4 | Co-immunoprecipitation |  | Human glomerular mesangial cell | Not used |  | Bovine | Full-length | 18256307
TRPP1 |  | TRPC7 | Co-immunoprecipitation |  | HEK293 | Human | 1-697 | Mouse | Full-length | 19812035
TRPP1 |  | TRPV4 | Co-immunofluorescence staining | MDCK |  |  |  |  |  | 18695040
TRPP1 |  | TRPV4 | Co-immunofluorescence staining | Mouse orpk collecting duct cell line |  |  |  |  |  | 23977387
TRPP1 |  | TRPV4 | Co-immunoprecipitation |  | HEK293 tsA 201 | Human | Full-length | Mouse | Full-length | 20682256
TRPP1 |  | TRPV4 | Co-immunoprecipitation |  | Rat mesenteric artery endothelial cell | Human | Full-length | Mouse | Full-length | 25114176
TRPP1 |  | TRPV4 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Mouse | Full-length | 25114176
TRPP1 |  | TRPV4 | Co-immunoprecipitation |  | HEK293 | Human | C-terminus | Mouse | C-terminus | 18695040
TRPP1 |  | TRPV4 | Co-immunoprecipitation | Mouse inner medullary collecting duct cell |  |  |  |  |  | 23977387
TRPP1 |  | TRPV4 | Co-immunoprecipitation | Mouse orpk collecting duct cell line |  |  |  |  |  | 23977387
TRPP1 |  | TRPV4 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Mouse | Full-length | 25114176
TRPP1 |  | TRPV4 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Mouse | Full-length | 18695040
TRPP1 |  | UBC | Co-immunoprecipitation | Mouse Inner medullary collecting duct cell |  |  |  |  |  | 18178578

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPP1 |  | CD2AP | Fusion protein-pull down assay | Mouse | 747-968 | Mouse | 331-637 |  |  | 10913159
TRPP1 |  | DIAP1/DRF1 | Co-immunoprecipitation | Human | 679-968 | Mouse | 543-1203 |  |  | 15123714
TRPP1 |  | EGFR | Co-immunoprecipitation | Human | 1-871 | Human | Not determined |  |  | 16135816
TRPP1 |  | HAX-1 | Yeast two-hybrid | Human | 618-658 | Mouse | 179-280 |  |  | 10760273
TRPP1 |  | HERP | Co-immunoprecipitation | Human | 689-968 | Mouse | Not determined |  |  | 18178578
TRPP1 |  | HERP | Co-immunoprecipitation | Human | 1-208 | Mouse | Not determined |  |  | 18178578
TRPP1 |  | ID2 | Yeast two-hybrid | Human | 679-968 | Human | 30-84 |  |  | 16311606
TRPP1 |  | IP3R1 | Fusion protein-pull down assay | Human | Not determined | Human | 1-345 |  |  | 20375013
TRPP1 |  | KIF3A | Fusion protein-pull down assay | Human | 682-968 | Human | 403-702 |  |  | 17008358
TRPP1 |  | KIF3A | Yeast two-hybrid | Human | 872-927 | Human | 403-702 |  |  | 16950792
TRPP1 |  | KIF3B | Fusion protein-pull down assay | Human | 682-968 | Human | 407-747 |  |  | 17008358
TRPP1 |  | KIF3B | Yeast two-hybrid | Human | 1-215 | Human | 407-747 |  |  | 17008358
TRPP1 |  | KIM1/TIM1 | Co-immunoprecipitation | Human | 1-30 | Human | Not determined |  |  | 18273441
TRPP1 |  | ơ-actinin-1 | Fusion protein-pull down assay | Human | 821-878 | Chicken | Not determined |  |  | 15843396
TRPP1 |  | ơ-actinin-1 | Yeast two-hybrid | Human | 821-878 | Human | 334-892 |  |  | 15843396
TRPP1 |  | ơ-actinin-2 | Fusion protein-pull down assay | Human | 821-878 | Chicken | Not determined |  |  | 15843396
TRPP1 |  | ơ-actinin-2 | Yeast two-hybrid | Human | 1-215 | Human | 341-894 |  |  | 15843396
TRPP1 |  | ơ-actinin-2 | Yeast two-hybrid | Human | 1-215 | Human | 596-728 |  |  | 15843396
TRPP1 |  | ơ-actinin-2 | Yeast two-hybrid | Human | 821-878 | Human | 341-894 |  |  | 15843396
TRPP1 |  | PACS-1 | Fluorescence probe labeling |  |  |  |  |  | 14.8 ƬM | 15692563
TRPP1 |  | PACS-1 | Fusion protein-pull down assay | Human | 741-871 | Human | 115-255 |  |  | 15692563
TRPP1 |  | PACS-2 | Fluorescence probe labeling |  |  |  |  |  | 15.4 ƬM | 15692563
TRPP1 |  | PACS-2 | Fusion protein-pull down assay | Human | Not determined | Human | 117-266 |  |  | 15692563
TRPP1 |  | Piezo1 | Co-immunoprecipitation | Mouse | N-terminus | Not specified | Not determined |  |  | 24157948
TRPP1 |  | PIGEA-14/CBY1 | Yeast two-hybrid | Human | 680-968 | Human | 60-112 |  |  | 15194699
TRPP1 |  | PIGEA-14/CBY1 | Yeast two-hybrid | Human | 833-923 | Human | Not determined |  |  | 15194699
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation | Human | 742-968 | Human | 4227-4303 |  |  | 11140688
TRPP1 |  | PKD1/Polycystin-1 | Co-immunoprecipitation | Human | 680-968 | Human | 1227-1339 |  |  | 9192675
TRPP1 |  | PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 681-968 | Not specified | 4077-4302 |  |  | 15692563
TRPP1 |  | PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 742-872 | Human | 4214-4248 |  |  | 9171830
TRPP1 |  | PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 833-895 | Human | 4213-4248 |  |  | 19556541
TRPP1 |  | PKD1/Polycystin-1 | Fusion protein-pull down assay | Human | 821-927 | Mouse | 4183-4270 |  |  | 19726544
TRPP1 |  | PKD1/Polycystin-1 | Yeast two-hybrid | Human | 742-872 | Human | 4214-4248 |  |  | 9171830
TRPP1 |  | PKD1/Polycystin-1 | Yeast two-hybrid | Human | 742-968 | Human | 1227-1339 |  |  | 9192675
TRPP1 |  | PKD1/Polycystin-1 | Yeast two-hybrid | Human | 822-895 | Human | 4124-4303 |  |  | 10097141
TRPP1 |  | PKD1L1/Polycystin-1L1 | Co-immunoprecipitation | Mouse | Full-length | Mouse | 2440-2607 |  |  | 21307093
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | Human | 1-221 | Human | 3872-4074 |  |  | 18235088
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | Human | Not determined | Human | 3850-4074 |  |  | 17008358
TRPP1 |  | PKHD1/FPC | Co-immunoprecipitation | Human | 90-139 | Human | 3903-3964 |  |  | 18782757
TRPP1 |  | PLCƣ2 | Co-immunoprecipitation | Human | 1-379 | Not specified | Not determined |  |  | 16135816
TRPP1 |  | RyR2 | Fusion protein-pull down assay | Human | 703-968 | Mouse | Not determined |  |  | 17404231
TRPP1 |  | RyR2 | Fusion protein-pull down assay | Human | 130-220 | Mouse | Not determined |  |  | 17404231
TRPP1 |  | Syntaxin5 | Co-immunoprecipitation | Human | 5-72 | Mouse | Not determined |  |  | 18836075
TRPP1 |  | Syntaxin5 | Fusion protein-pull down assay | Human | Not determined | Mouse | 256-333 |  |  | 18836075
TRPP1 |  | TAZ/WWTR1 | Fusion protein-pull down assay | Mouse | 678-966 | Mouse | 220-272 |  |  | 17636028
TRPP1 |  | Tropomyosin 1 | Yeast two-hybrid | Human | 821-878 | Human | 152-196 |  |  | 12527301
TRPP1 |  | Troponin I 3 | Yeast two-hybrid | Human | 872-927 | Human | 1-107 |  |  | 12525172
TRPP1 |  | Troponin I 3 | Yeast two-hybrid | Human | 872-927 | Human | 106-158 |  |  | 12525172
TRPP1 |  | TRPC1 | Atomic force microscopy(AFM) analysis |  |  |  |  | 2:2 |  | 19850920
TRPP1 |  | TRPC1 | Atomic force microscopy(AFM) analysis |  |  |  |  | 2:2 |  | 19193631
TRPP1 |  | TRPC1 | Co-immunoprecipitation | Human | 1-643 | Human | Not determined |  |  | 10097141
TRPP1 |  | TRPC1 | Co-immunoprecipitation | Human | 679-968 | Human | Not determined |  |  | 10097141
TRPP1 |  | TRPC1 | Yeast two-hybrid | Human | 822-895 | Human | 639-750 |  |  | 10097141
TRPP1 |  | TRPC3 | Fusion protein-pull down assay | Human | 1-697 | Mouse | 659-753 |  |  | 19812035
TRPP1 |  | TRPV4 | Atomic force microscopy(AFM) analysis |  |  |  |  | 2:2 |  | 20682256

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPP1 |  | 80K-H | Co-immunofluorescence staining |  | Retain in the endoplasmic reticulum |  | 19801576
TRPP1 |  | KIF3A | Patch clamp |  |  | Activation | 16950792
TRPP1 |  | ơ-actinin | Patch clamp |  |  | Activation | 15843396
TRPP1 |  | PKA | In vitro PTM assay | Phosphorylation (Ser-829) |  |  | 23390129
TRPP1 |  | PKD1/Polycystin-1 | Co-immunofluorescence staining |  | Increase in plasma membrane level |  | 11140688
TRPP1 |  | PKD1/Polycystin-1 | Patch clamp |  |  | New channel creation | 11140688
TRPP1 |  | Syntaxin5 | Patch clamp |  |  | Inhibition | 18836075
TRPP1 |  | TRPC1 | Patch clamp |  |  | New channel creation | 18323855
TRPP1 |  | TRPC1 | Patch clamp |  |  | New channel creation | 25114176
TRPP1 |  | TRPV4 | Patch clamp |  |  | New channel creation | 25114176
TRPP1 |  | TRPV4 | Patch clamp |  |  | New channel creation | 18695040

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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