# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPC6 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (46)
- Biological Process (6)
- Disease (1)

Name: Short transient receptor potential channel 6 (TRPC6)
Official Symbol: TRPC6 provided by HGNC
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 7225 | Q9Y210 | DIP-35693N | Q9Y210 |  | 113076 | Q9Y210 | 491 | hsa:7225 | 603652
Mouse | 22068 | Q61143 |  |  |  | 204332 | Q61143 |  | mmu:22068 |
Rat | 89823 | Q99N78 |  |  |  | 250145 | Q99N78 |  | rno:89823 |

PPI pairs:

Bkca | Calcineurin | Calmodulin | Cav1.2 | Clathrin-H1 | Drebrin | Dynamin-1 | Epo-R
FKBP12 | FYN | GC-A | Gơq/11 | IP3R2 | IP3R3 | M1 mAChR | MxA
NKAơ1 | Nephrin | Orai1 | Orai2 | Orai3 | PDE3A | PKA | PKCơ
PKG1 | PLCƣ1 | Podocin | RNF24 | Rab9 | S100A10 | SERCA2 | SERCA3
SNAPIN | SNF8 | STIM1 | Src | Syntaxin3 | TRPA1 | TRPC1 | TRPC2
TRPC3 | TRPC4 | TRPC5 | TRPC7 | UBC | ơ-actinin

Biological Process:

- GO:0007411 : axon guidance
- GO:0006812 : cation transport
- GO:0007204 : elevation of cytosolic calcium ion concentration
- GO:0030168 : platelet activation
- GO:0051928 : positive regulation of calcium ion transport
- GO:0032414 : positive regulation of ion transmembrane transporter activity

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:603652 : Glomerulosclerosis, focal segmental, 2 (OMIM:603965 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC6 |  | BKca | Inference |  |  |  |  |  | Prediction | 19052171
TRPC6 |  | Calcineurin | Inference |  |  |  |  |  | Prediction | 15994335
TRPC6 |  | Calmodulin | Inference |  |  |  |  |  | Prediction | 11290752
TRPC6 |  | Cav1.2 | Inference |  |  |  |  |  | Prediction | 21672930
TRPC6 |  | Clathrin-H1 | Speculation |  |  |  |  |  | Prediction | 16025302
TRPC6 |  | Drebrin | Speculation |  |  |  |  |  | Prediction | 16025302
TRPC6 |  | Dynamin-1 | Speculation |  |  |  |  |  | Prediction | 16025302
TRPC6 |  | Epo-R | Inference |  |  |  |  |  | Prediction | 19074769
TRPC6 |  | FKBP12 | Inference |  |  |  |  |  | Prediction | 15994335
TRPC6 |  | FYN | Inference |  |  |  |  |  | Prediction | 14761972
TRPC6 |  | GC-A | Inference |  |  |  |  |  | Prediction | 22027011
TRPC6 |  | Gơq/11 | Inference |  |  |  |  |  | Prediction | 15623527
TRPC6 |  | IP3R2 | Inference |  |  |  |  |  | Prediction | 18191041
TRPC6 |  | IP3R3 | Inference |  |  |  |  |  | Prediction | 10611319
TRPC6 |  | M1 mAChR | Inference |  |  |  |  |  | Prediction | 15994335
TRPC6 |  | MxA | Yeast two-hybrid | Human | 3-259 | Human | Fetal brain | cDNA library |  | 15757897
TRPC6 |  | Nephrin | Inference |  |  |  |  |  | Prediction | 15924139
TRPC6 |  | NKAơ1 | Speculation |  |  |  |  |  | Prediction | 16025302
TRPC6 |  | ơ-actinin | Speculation |  |  |  |  |  | Prediction | 16025302
TRPC6 |  | Orai1 | Inference |  |  |  |  |  | Prediction | 17360584
TRPC6 |  | Orai2 | Speculation |  |  |  |  |  | Prediction | 22640869
TRPC6 |  | Orai3 | Speculation |  |  |  |  |  | Prediction | 22640869
TRPC6 |  | PDE3A | Inference |  |  |  |  |  | Prediction | 21799177
TRPC6 |  | PKA | Inference |  |  |  |  |  | Prediction | 21799177
TRPC6 |  | PKCơ | Inference |  |  |  |  |  | Prediction | 15994335
TRPC6 |  | PKG1 | Inference |  |  |  |  |  | Prediction | 18617565
TRPC6 |  | PLCƣ1 | Inference |  |  |  |  |  | Prediction | 19074769
TRPC6 |  | Podocin | Inference |  |  |  |  |  | Prediction | 15924139
TRPC6 |  | Rab9 | Inference |  |  |  |  |  | Prediction | 20346379
TRPC6 |  | RNF24 | Yeast two-hybrid | Not specified | 3-259 | Human | Fetal brain | cDNA library |  | 17850865
TRPC6 |  | S100A10 | Inference |  |  |  |  |  | Prediction | 23671622
TRPC6 |  | SERCA2 | Inference |  |  |  |  |  | Prediction | 18191041
TRPC6 |  | SERCA3 | Inference |  |  |  |  |  | Prediction | 18191041
TRPC6 |  | SNAPIN | Inference |  |  |  |  |  | Prediction | 17684020
TRPC6 |  | SNF8 | Yeast two-hybrid | Human | 1-406 | Human | Kidney | cDNA library |  | 23171048
TRPC6 |  | SRC | Inference |  |  |  |  |  | Prediction | 16407161
TRPC6 |  | Src | Speculation |  |  |  |  |  | Prediction | 14761972
TRPC6 |  | STIM1 | Inference |  |  |  |  |  | Prediction | 19260825
TRPC6 |  | Syntaxin3 | Inference |  |  |  |  |  | Prediction | 15623527
TRPC6 |  | TRPA1 | Inference |  |  |  |  |  | Prediction | 23994313
TRPC6 |  | TRPC1 | Inference |  |  |  |  |  | Prediction | 12857742
TRPC6 |  | TRPC2 | Inference |  |  |  |  |  | Prediction | 14699131
TRPC6 |  | TRPC3 | Inference |  |  |  |  |  | Prediction | 12032305
TRPC6 |  | TRPC4 | Inference |  |  |  |  |  | Prediction | 12857742
TRPC6 |  | TRPC5 | Inference |  |  |  |  |  | Prediction | 12857742
TRPC6 |  | TRPC7 | Inference |  |  |  |  |  | Prediction | 12032305
TRPC6 |  | UBC | Inference |  |  |  |  |  | Prediction | 17110928

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPC6 |  | BKca | Fusion protein-pull down assay | Not used |  | Mouse podocyte lysates | Chicken | Full-length | E. coli | 19052171
TRPC6 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 828-883 | E. coli | Not specified | Full-length | In vitro translation | 12379180
TRPC6 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 1-396 | In vitro translation | Not specified | Full-length | E. coli | 12601176
TRPC6 |  | FKBP12 | Co-immunoprecipitation | Mouse | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065
TRPC6 |  | FYN | Fusion protein-pull down assay | Mouse | Full-length | HEK293 lysates | Human | 149-257 | E. coli | 14761972
TRPC6 |  | MxA | Fusion protein-pull down assay | Human | 95-243 | In vitro translation | Human | 572-662 | E. coli | 15757897
TRPC6 |  | Orai1 | Fusion protein-pull down assay | Mouse | 1-396 | In vitro translation | Human | Full-length | E. coli | 17360584
TRPC6 |  | Orai1 | Fusion protein-pull down assay | Mouse | 732-930 | In vitro translation | Human | Full-length | E. coli | 17360584
TRPC6 |  | RNF24 | Fusion protein-pull down assay | Not specified | 3-259 | In vitro translation | Human | 98-148 | E. coli | 17850865
TRPC6 |  | RNF24 | Yeast two-hybrid | Not specified | 3-259 | Yeast | Human | 98-148 | Yeast | 17850865
TRPC6 |  | S100A10 | Fluorescence probe labeling | Rat | 801-878 | E. coli | Human | Full-length | E. coli | 23671622
TRPC6 |  | SRC | Fusion protein-pull down assay | Mouse | 1-396 | In vitro translation | Chicken | Full-length | E. coli | 16407161

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC6 |  | BKca | Co-immunofluorescence staining |  | HEK293T | Not specified | Full-length | Not specified | Full-length | 19052171
TRPC6 |  | BKca | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 19052171
TRPC6 |  | BKca | Co-immunoprecipitation |  | HEK293T | Not specified | Full-length | Not specified | Full-length | 19052171
TRPC6 |  | Calcineurin | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335
TRPC6 |  | Calmodulin | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335
TRPC6 |  | Cav1.2 | Co-immunoprecipitation | Chick embryonic heart lysates |  |  |  |  |  | 21672930
TRPC6 |  | Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC6 |  | Drebrin | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC6 |  | Dynamin-1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC6 |  | Epo-R | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 19074769
TRPC6 |  | FKBP12 | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335
TRPC6 |  | FKBP12 | Co-immunoprecipitation | Rat cerebral cortex |  |  |  |  |  | 15199065
TRPC6 |  | FYN | Co-immunofluorescence staining |  | CHO-K1 | Mouse | Full-length | Human | Full-length | 14761972
TRPC6 |  | FYN | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 14761972
TRPC6 |  | FYN | Co-immunoprecipitation |  | COS-7 | Mouse | Full-length | Human | Full-length | 14761972
TRPC6 |  | GC-A | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011
TRPC6 |  | GC-A | Co-immunoprecipitation |  | Mouse cardiac myocyte lysates | Not used |  | Rat | Full-length | 22027011
TRPC6 |  | Gơq/11 | Co-immunoprecipitation | MDCK |  |  |  |  |  | 15623527
TRPC6 |  | IP3R2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18191041
TRPC6 |  | IP3R3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 14505576
TRPC6 |  | IP3R3 | Co-immunoprecipitation |  | HEK293T | Mouse | Full-length | Human | Full-length | 10611319
TRPC6 |  | M1 mAChR | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335
TRPC6 |  | MxA | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 15757897
TRPC6 |  | Nephrin | Co-immunofluorescence staining |  | Mouse podocytes section | Mouse | Full-length | Not used |  | 15924139
TRPC6 |  | Nephrin | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 15924139
TRPC6 |  | Nephrin | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 15924139
TRPC6 |  | Nephrin | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 22155451
TRPC6 |  | Nephrin | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 22155451
TRPC6 |  | NKAơ1 | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 16025302
TRPC6 |  | NKAơ1 | Co-immunoprecipitation | Rat kidney lysates |  |  |  |  |  | 16025302
TRPC6 |  | NKAơ1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC6 |  | ơ-actinin | Co-immunofluorescence staining | Rat ventricular myocytes |  |  |  |  |  | 24146259
TRPC6 |  | ơ-actinin | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC6 |  | Orai1 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 19260825
TRPC6 |  | Orai1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 17360584
TRPC6 |  | Orai2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 22640869
TRPC6 |  | Orai3 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 22640869
TRPC6 |  | PDE3A | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 21799177
TRPC6 |  | PDE3A | Co-immunoprecipitation | Rat aortic smooth muscle cell |  |  |  |  |  | 21799177
TRPC6 |  | PKA | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 21799177
TRPC6 |  | PKA | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Not specified | Not specified | 23645677
TRPC6 |  | PKCơ | Co-immunoprecipitation | PC12D |  |  |  |  |  | 15994335
TRPC6 |  | PLCƣ1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Rat | Full-length | 19074769
TRPC6 |  | Podocin | Co-immunofluorescence staining |  | Mouse podocytes section | Mouse | Full-length | Not used |  | 15924139
TRPC6 |  | Podocin | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Mouse | Full-length | 24596097
TRPC6 |  | Podocin | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 15924139
TRPC6 |  | Podocin | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 15924139
TRPC6 |  | Rab9 | Co-immunofluorescence staining |  | HeLa | Mouse | Full-length | Human | Full-length | 20346379
TRPC6 |  | Rab9 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 20346379
TRPC6 |  | RNF24 | Co-immunofluorescence staining |  | HEK293 | Not specified | Full-length | Human | Full-length | 17850865
TRPC6 |  | SERCA2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18191041
TRPC6 |  | SERCA3 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18191041
TRPC6 |  | SNAPIN | Co-immunoprecipitation | Rat brain cortex |  |  |  |  |  | 17684020
TRPC6 |  | SNF8 | Co-immunofluorescence staining |  | M1R-HEK293T | Human | Full-length | Human | Full-length | 23171048
TRPC6 |  | SNF8 | Co-immunoprecipitation |  | M1R-HEK293T | Human | Full-length | Human | Full-length | 23171048
TRPC6 |  | Src | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 14761972
TRPC6 |  | STIM1 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 19260825
TRPC6 |  | STIM1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 23068106
TRPC6 |  | STIM1 | Co-immunoprecipitation |  |  | Not specified | Full-length (mutant) | Human | Full-length | 24464579
TRPC6 |  | Syntaxin3 | Co-immunoprecipitation | MDCK |  |  |  |  |  | 15623527
TRPC6 |  | TRPA1 | Co-immunoprecipitation | MEG-01 |  |  |  |  |  | 23994313
TRPC6 |  | TRPC1 | Co-immunofluorescence staining | Human glomerular mesangial cell |  |  |  |  |  | 16418302
TRPC6 |  | TRPC1 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18191041
TRPC6 |  | TRPC1 | Co-immunoprecipitation | Human glomerular mesangial cell |  |  |  |  |  | 16418302
TRPC6 |  | TRPC1 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC6 |  | TRPC2 | Co-immunoprecipitation |  | CHO | Mouse | Full-length | Mouse | Full-length | 14699131
TRPC6 |  | TRPC2 | Co-immunoprecipitation | Mouse brain erythroblast |  |  |  |  |  | 14699131
TRPC6 |  | TRPC3 | Co-immunofluorescence staining | MDA-MB-231 |  |  |  |  |  | 19689790
TRPC6 |  | TRPC3 | Co-immunoprecipitation | dnTRPC6 Neonatal rat ventricular myocytes |  |  |  |  |  | 20351294
TRPC6 |  | TRPC3 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 19260825
TRPC6 |  | TRPC3 | Co-immunoprecipitation | MDA-MB-231 |  |  |  |  |  | 19689790
TRPC6 |  | TRPC3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 12032305
TRPC6 |  | TRPC3 | Co-immunoprecipitation | Rat brain synaptome |  |  |  |  |  | 12377790
TRPC6 |  | TRPC3 | Co-immunoprecipitation |  | Sf9 | Mouse | Full-length | Human | Full-length | 12377790
TRPC6 |  | TRPC3 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 16270640
TRPC6 |  | TRPC3 | Co-immunoprecipitation |  | MDCK | Not used |  | Not specified | Full-length | 15623527
TRPC6 |  | TRPC3 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 19074769
TRPC6 |  | TRPC3 | Co-immunoprecipitation | TF-1 |  |  |  |  |  | 19074769
TRPC6 |  | TRPC3 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Human | Full-length | 12032305
TRPC6 |  | TRPC4 | Co-immunoprecipitation |  | HEK293 | Not specifed | Full-length | Mouse | Full-length | 17486119
TRPC6 |  | TRPC4 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC6 |  | TRPC5 | Co-immunoprecipitation | Rabbit coronary artery |  |  |  |  |  | 18356201
TRPC6 |  | TRPC5 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC6 |  | TRPC7 | Co-immunoprecipitation |  | Sf9 | Mouse | Full-length | Mouse | Full-length | 12377790
TRPC6 |  | TRPC7 | Co-immunoprecipitation | Rat brain synaptome |  |  |  |  |  | 12377790
TRPC6 |  | TRPC7 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Mouse | Full-length | 12032305

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC6 |  | Calmodulin | Fluorescence probe labeling |  |  |  |  |  | 320 nM | 19932145
TRPC6 |  | Calmodulin | Fluorescence probe labeling | Mouse | 843-872 | Not specified | Not determined |  | 290 nM | 11290752
TRPC6 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 838-872 | Not specified | Not determined |  |  | 11290752
TRPC6 |  | FYN | Fusion protein-pull down assay | Mouse | 1-388 | Human | 149-257 |  |  | 14761972
TRPC6 |  | IP3R3 | Fusion protein-pull down assay | Mouse | 838-872 | Human | 669-698 |  |  | 11290752
TRPC6 |  | MxA | Fusion protein-pull down assay | Human | 95-243 | Human | 572-662 |  |  | 15757897
TRPC6 |  | MxA | Yeast two-hybrid | Human | 3-259 | Human | 542-662 |  |  | 15757897
TRPC6 |  | Rab9 | Fusion protein-pull down assay | Mouse | 732-835 | Human | Not determined |  |  | 20346379
TRPC6 |  | Rab9 | Fusion protein-pull down assay | Mouse | 828-883 | Human | Not determined |  |  | 20346379
TRPC6 |  | RNF24 | Yeast two-hybrid | Not specified | 3-130 | Human | 98-148 |  |  | 17850865
TRPC6 |  | RNF24 | Yeast two-hybrid | Not specified | 122-259 | Human | 98-148 |  |  | 17850865
TRPC6 |  | S100A10 | Fluorescence probe labeling | Rat | 801-878 | Human | Not determined |  | 310 nM | 23671622
TRPC6 |  | SNF8 | Co-immunoprecipitation | Human | 1-106 | Human | Not determined |  |  | 23171048
TRPC6 |  | SNF8 | Yeast two-hybrid | Human | 1-106 | Human | Not determined |  |  | 23171048
TRPC6 |  | TRPC4 | Co-immunoprecipitation | Mouse | 715-930 | Mouse | 1-304 |  |  | 16916799

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPC6 |  | Calcineurin | In vivo PTM assay | Dephosphorylation |  |  | 24740790
TRPC6 |  | Calmodulin | Calcium measurement |  |  | Activation | 12379180
TRPC6 |  | Calmodulin | Patch clamp |  |  | Activation | 12379180
TRPC6 |  | FYN | In vivo PTM assay | Phosphorylation |  |  | 14761972
TRPC6 |  | FYN | Patch clamp |  |  | Activation | 14761972
TRPC6 |  | M1 mAChR | Calcium measurement |  |  | Activation | 15994335
TRPC6 |  | MxA | Calcium measurement |  |  | Activation | 15757897
TRPC6 |  | PKA | In vitro PTM assay | Phosphorylation (Thr-69) |  |  | 22001259
TRPC6 |  | PKA | In vitro PTM assay | Phosphorylation (Ser-28) |  |  | 22001259
TRPC6 |  | PKA | In vitro PTM assay | Phosphorylation (Thr-70) |  |  | 23645677
TRPC6 |  | PKA | In vivo PTM assay | Phosphorylation (Thr-70) |  |  | 23645677
TRPC6 |  | PKCơ | In vitro PTM assay | Phosphorylation (Ser-714) |  |  | 15994335
TRPC6 |  | PKG1 | In vitro PTM assay | Phosphorylation (Thr-69) |  |  | 18617565
TRPC6 |  | PKG1 | In vivo PTM assay | Phosphorylation (Thr-69) |  |  | 24740790
TRPC6 |  | RNF24 | Cell surface biotinylation |  | Decrease in plasma membrane level |  | 17850865
TRPC6 |  | SNF8 | Patch clamp |  |  | Activation | 23171048
TRPC6 |  | TRPC1 | Patch clamp |  |  | Inhibition | 20660561
TRPC6 |  | TRPC5 | Patch clamp |  |  | Inhibition | 20660561
TRPC6 |  | UBC | In vivo PTM assay | Ubiquitination |  |  | 17110928

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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