# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPC3 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (115)
- Biological Process (6)
- Disease (0)

Name: Short transient receptor potential channel 3 (TRPC3)
Official Symbol: TRPC3 provided by HGNC
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 7222 | Q13507 | DIP-34311N | Q13507 |  | 113073 | Q13507 | 488 | hsa:7222 | 602345
Mouse | 22065 | Q9QZC1 |  |  |  | 204329 | Q9QZC1 |  | mmu:22065 |
Rat | 60395 | Q9JMI9 | DIP-59688N |  |  | 248816 | Q9JMI9 |  | rno:60395 |

PPI pairs:

14-3-3 protein Ƣ/ơ | 14-3-3 protein ƥ | 14-3-3 protein ƨ | ADT1 | ALDOC | AP2A2 | AP2B1 | AQP-2
ATP synthase Ƣ | Aconitase | Annexin 5 | Basp1 | Bkca | CaSR | Calmodulin | Calreticulin
Caskin-1 | Cav1.2 | Caveolin-1 | Citrate synthase | Clathrin-H1 | Cytochrome c oxidase 2 | Cytochrome c oxidase 5A | DRP-2
Dynamin-1 heavy chain 1 | Dynamin-1L | Epo-R | Ezrin | FKBP12 | Fibronectin | Fumarase | GC-A
GLUD1 | GLUT-4 | Gz-ơ | Gơq | Gơq/11 | Homer | Homer-1 | IP3R1
IP3R2 | IP3R3 | Idh3B | Junctate | Junctophilin-2 | LETM1 | MAP2 | MDH1
MDH2 | MG29 | MxA | Myosin-10 | NCAM1 | NCX1 | NKAơ1 | NKAơ2
NKAơ3 | Neurofascin | Neuromodulin | ORP-150 | Orai1 | Orai2 | Orai3 | PDE3A
PEBP1 | PGK1 | PKA | PKCƢ | PKG1 | PLCƢ3 | PLCƣ1 | PLCƣ2
PMCA | PMCA2 | PMCA3 | PMCA4 | Pyruvate kinase M1/M2 | RACK1 | RAP1A | RAP1B
RNF24 | RyR | RyR2 | SERCA2 | SNAP23 | SNAP25 | SOD2 | STIM1
STIM2 | SV2A | Slc1a2 | Slc1a3 | Src | Synapsin1 | Synaptotagmin 1 | Syntaxin1a
Syntaxin3 | TRPC1 | TRPC4 | TRPC5 | TRPC6 | TRPC7 | TRPM4 | TRPP1
Tenascin-R | TrkB | UCH-L1 | VAMP2 | VAT2 | VDAC1 | VDAC3 | WNK4
p97/VCP | ơ-actinin | ơSNAP

Biological Process:

- GO:0007411 : axon guidance
- GO:0007602 : phototransduction
- GO:0030168 : platelet activation
- GO:0010524 : positive regulation of calcium ion transport into cytosol
- GO:0033198 : response to ATP
- GO:0051592 : response to calcium ion

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | 14-3-3 protein Ƣ/ơ | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | 14-3-3 protein ƥ | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | 14-3-3 protein Ƨ | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Aconitase | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | ADT1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | ALDOC | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Annexin 5 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | AP2A2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | AP2B1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | AQP-2 | Inference |  |  |  |  |  | Prediction | 17699554
TRPC3 |  | ATP synthase Ƣ | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Basp1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | BKca | Inference |  |  |  |  |  | Prediction | 19052171
TRPC3 |  | Calmodulin | Inference |  |  |  |  |  | Prediction | 11248050
TRPC3 |  | Calreticulin | Inference |  |  |  |  |  | Prediction | 18215135
TRPC3 |  | Caskin-1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | CaSR | Inference |  |  |  |  |  | Prediction | 22778254
TRPC3 |  | Cav1.2 | Inference |  |  |  |  |  | Prediction | 21672930
TRPC3 |  | Caveolin-1 | Inference |  |  |  |  |  | Prediction | 11524429
TRPC3 |  | Citrate synthase | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Clathrin-H1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Cytochrome c oxidase 2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Cytochrome c oxidase 5A | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | DRP-2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Dynamin-1 heavy chain 1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Dynamin-1L | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Epo-R | Inference |  |  |  |  |  | Prediction | 18276585
TRPC3 |  | Ezrin | Inference |  |  |  |  |  | Prediction | 11524429
TRPC3 |  | Fibronectin | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | FKBP12 | Inference |  |  |  |  |  | Prediction | 15199065
TRPC3 |  | Fumarase | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | GC-A | Inference |  |  |  |  |  | Prediction | 22027011
TRPC3 |  | GLUD1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | GLUT-4 | Inference |  |  |  |  |  | Prediction | 17156765
TRPC3 |  | Gơq | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Gơq/11 | Inference |  |  |  |  |  | Prediction | 11524429
TRPC3 |  | Gz-ơ | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Homer-1 | Inference |  |  |  |  |  | Prediction | 16887806
TRPC3 |  | Idh3B | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | IP3R1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | IP3R1 | Inference |  |  |  |  |  | Prediction | 10518223
TRPC3 |  | IP3R2 | Inference |  |  |  |  |  | Prediction | 11290752
TRPC3 |  | IP3R3 | Inference |  |  |  |  |  | Prediction | 10611319
TRPC3 |  | Junctate | Inference |  |  |  |  |  | Prediction | 15302852
TRPC3 |  | Junctophilin-2 | Inference |  |  |  |  |  | Prediction | 18215135
TRPC3 |  | LETM1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | MAP2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | MDH1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | MDH2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | MG29 | Inference |  |  |  |  |  | Prediction | 18215135
TRPC3 |  | MxA | Inference |  |  |  |  |  | Prediction | 15757897
TRPC3 |  | Myosin-10 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | NCAM1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | NCX1 | Inference |  |  |  |  |  | Prediction | 14736881
TRPC3 |  | Neurofascin | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Neuromodulin | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | NKAơ1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | NKAơ1 | Inference |  |  |  |  |  | Prediction | 17012351
TRPC3 |  | NKAơ2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | NKAơ3 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | ơ-actinin | Speculation |  |  |  |  |  | Prediction | 24146259
TRPC3 |  | Orai1 | Inference |  |  |  |  |  | Prediction | 17360584
TRPC3 |  | Orai2 | Inference |  |  |  |  |  | Prediction | 17360584
TRPC3 |  | Orai3 | Inference |  |  |  |  |  | Prediction | 17360584
TRPC3 |  | ORP-150 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | ơSNAP | Yeast two-hybrid | Human | 1-341 | Rat | Brain | cDNA library |  | 15327778
TRPC3 |  | p97/VCP | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | PDE3A | Inference |  |  |  |  |  | Prediction | 21799177
TRPC3 |  | PEBP1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | PGK1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | PKA | Inference |  |  |  |  |  | Prediction | 21799177
TRPC3 |  | PKCƢ | Inference |  |  |  |  |  | Prediction | 20179100
TRPC3 |  | PKG1 | Inference |  |  |  |  |  | Prediction | 14983059
TRPC3 |  | PLCƢ1 | Inference |  |  |  |  |  | Prediction | 11524429
TRPC3 |  | PLCƣ1 | Inference |  |  |  |  |  | Prediction | 12437926
TRPC3 |  | PLCƣ2 | Inference |  |  |  |  |  | Prediction | 12970180
TRPC3 |  | PLCƢ2 | Inference |  |  |  |  |  | Prediction | 15623527
TRPC3 |  | PLCƢ3 | Inference |  |  |  |  |  | Prediction | 15623527
TRPC3 |  | PMCA | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | PMCA | Speculation |  |  |  |  |  | Prediction | 16887806
TRPC3 |  | PMCA2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | PMCA3 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | PMCA4 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Pyruvate kinase M1/M2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | RACK1 | Yeast two-hybrid | Not specified | 1-341 | Human | Embroynic kidney | cDNA library |  | 18755685
TRPC3 |  | RAP1A | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | RAP1B | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | RNF24 | Inference |  |  |  |  |  | Prediction | 17850865
TRPC3 |  | RyR | Inference |  |  |  |  |  | Prediction | 10983988
TRPC3 |  | RyR2 | Inference |  |  |  |  |  | Prediction | 17012351
TRPC3 |  | SERCA2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | SERCA2 | Inference |  |  |  |  |  | Prediction | 11524429
TRPC3 |  | Slc1a2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Slc1a3 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | SNAP23 | Inference |  |  |  |  |  | Prediction | 15327778
TRPC3 |  | SNAP25 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | SOD2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | SRC | Inference |  |  |  |  |  | Prediction | 16407161
TRPC3 |  | STIM1 | Speculation |  |  |  |  |  | Prediction | 22640869
TRPC3 |  | STIM2 | Speculation |  |  |  |  |  | Prediction | 22640869
TRPC3 |  | SV2A | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Synapsin1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Synaptotagmin 1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Syntaxin1a | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | Syntaxin3 | Inference |  |  |  |  |  | Prediction | 15327778
TRPC3 |  | Tenascin-R | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | TrkB | Inference |  |  |  |  |  | Prediction | 10677043
TRPC3 |  | TRPC1 | Inference |  |  |  |  |  | Prediction | 9215637
TRPC3 |  | TRPC4 | Inference |  |  |  |  |  | Prediction | 16537542
TRPC3 |  | TRPC5 | Inference |  |  |  |  |  | Prediction | 12857742
TRPC3 |  | TRPC6 | Inference |  |  |  |  |  | Prediction | 12032305
TRPC3 |  | TRPC7 | Inference |  |  |  |  |  | Prediction | 12032305
TRPC3 |  | TRPM4 | Yeast two-hybrid | Not used as a bait |  | Human | Brain | cDNA library |  | 18262493
TRPC3 |  | TRPP1 | Inference |  |  |  |  |  | Prediction | 19812035
TRPC3 |  | UCH-L1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | VAMP2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | VAMP2 | Yeast two-hybrid | Human | 1-341 | Rat | Brain | cDNA library |  | 15327778
TRPC3 |  | VAT2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | VDAC1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | VDAC3 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | WNK4 | Inference |  |  |  |  |  | Prediction | 21670282

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPC3 |  | BKca | Fusion protein-pull down assay | Not used |  | Mouse podocyte lysates | Chicken | Full-length | E. coli | 19052171
TRPC3 |  | Calmodulin | Fusion protein-pull down assay | Human | 1-340 | In vitro translation | Not specified | Full-length | E. coli | 12601176
TRPC3 |  | Calmodulin | Fusion protein-pull down assay | Human | 742-795 | E. coli | Rat | Full-length | In vitro translation | 11248050
TRPC3 |  | FKBP12 | Co-immunoprecipitation | Human | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065
TRPC3 |  | Homer-1 | Fusion protein-pull down assay | Human | Full-length | HEK293 lysates | Human | Full-length | E. coli | 16887806
TRPC3 |  | IP3R3 | Fusion protein-pull down assay | Human | 676-848 | In vitro translation | Human | 638-926 | E. coli | 10611319
TRPC3 |  | Junctate | Fusion protein-pull down assay | Bovine | Full-length | HEK293 lysates | Not specified | 1-85 | Not specified | 15302852
TRPC3 |  | Junctophilin-2 | Fusion protein-pull down assay | Not used |  | Rabbit back and leg fast-twich skeletal muscle lysates | Mouse | Full-length | E. coli | 19277847
TRPC3 |  | MxA | Fusion protein-pull down assay | Human | 1-201 | In vitro translation | Human | 572-662 | E. coli | 15757897
TRPC3 |  | NCX1 | Fusion protein-pull down assay | Human | 742-848 | E. coli | Not used |  | HEK293 lysates | 14736881
TRPC3 |  | NCX1 | Fusion protein-pull down assay | Human | 670-848 | E. coli | Not used |  | Rat Cardiomyocyte lysates | 17129578
TRPC3 |  | Orai1 | Fusion protein-pull down assay | Human | 1-340 | In vitro translation | Human | Full-length | E. coli | 17360584
TRPC3 |  | Orai1 | Fusion protein-pull down assay | Human | 676-848 | In vitro translation | Human | Full-length | E. coli | 17360584
TRPC3 |  | PKCƢ | Fusion protein-pull down assay | Mouse | 659-836 | E. coli | Not used |  | DT40 lysates | 20179100
TRPC3 |  | PLCƣ1 | Yeast two-hybrid | Human | 1-340 | Yeast | Rat | 750-1290 | Yeast | 12437926
TRPC3 |  | PLCƣ1 | Yeast two-hybrid | Human | 1-171 | Yeast | Rat | 796-920 | Yeast | 15744307
TRPC3 |  | RNF24 | Fusion protein-pull down assay | Not specified | 1-201 | In vitro translation | Human | 98-148 | E. coli | 17850865
TRPC3 |  | SRC | Fusion protein-pull down assay | Mouse | 1-340 | In vitro translation | Chicken | Full-length | E. coli | 16407161
TRPC3 |  | TRPC1 | Fusion protein-pull down assay | Not specified | Full-length | HEK293 lysates | Not specified | 1-347 | E. coli | 15834157
TRPC3 |  | TRPC1 | Fusion protein-pull down assay | Human | 38-381 | E. coli | Not used |  | Rabbit fast switch muscle lysates | 24613381
TRPC3 |  | TRPC1 | Yeast two-hybrid | Not specified | 642-842 | Yeast | Not specified | 642-842 | Yeast | 15834157
TRPC3 |  | TRPM4 | Yeast two-hybrid | Human | Full-length | Yeast | Human | Full-length | Yeast | 18262493

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | ADT1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | AQP-2 | Co-immunofluorescence staining | Rat kidney medullary collecting duct |  |  |  |  |  | 20107112
TRPC3 |  | AQP-2 | Co-immunofluorescence staining | Rat kidney duct section |  |  |  |  |  | 17699554
TRPC3 |  | AQP-2 | Co-immunoprecipitation | mIMCD-3 |  |  |  |  |  | 17699554
TRPC3 |  | AQP-2 | Co-immunoprecipitation | Rat medulla lysates |  |  |  |  |  | 17699554
TRPC3 |  | BKca | Co-immunofluorescence staining |  | HEK293T | Not specified | Full-length | Not specified | Full-length | 19052171
TRPC3 |  | BKca | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 19052171
TRPC3 |  | BKca | Co-immunoprecipitation |  | HEK293T | Not specified | Full-length | Not specified | Full-length | 19052171
TRPC3 |  | Calmodulin | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135
TRPC3 |  | Calreticulin | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135
TRPC3 |  | CaSR | Co-immunofluorescence staining | Mouse submandibular gland (SMG) ductal tissue section |  |  |  |  |  | 22778254
TRPC3 |  | CaSR | Co-immunoprecipitation | Mouse submandibular gland (SMG) ductal cell lysates |  |  |  |  |  | 22778254
TRPC3 |  | Cav1.2 | Co-immunoprecipitation | Chick embryonic heart lysates |  |  |  |  |  | 21672930
TRPC3 |  | Caveolin-1 | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | Caveolin-1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | DRP-2 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | Dynamin-1 heavy chain 1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | Epo-R | Co-immunofluorescence staining |  | HEK293T | Human | Full-length | Human | Full-length | 19074769
TRPC3 |  | Epo-R | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 21757714
TRPC3 |  | Epo-R | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 18276585
TRPC3 |  | Epo-R | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 19074769
TRPC3 |  | Epo-R | Co-immunoprecipitation | TF-1 |  |  |  |  |  | 19074769
TRPC3 |  | Ezrin | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | FKBP12 | Co-immunoprecipitation | Rat cerebral cortex |  |  |  |  |  | 15199065
TRPC3 |  | GC-A | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011
TRPC3 |  | GC-A | Co-immunoprecipitation |  | Mouse cardiac myocyte lysates | Not used |  | Rat | Full-length | 22027011
TRPC3 |  | GC-A | Fluorescence resonance energy transfer |  | HEK293 | Not specified | Full-length | Rat | Full-length | 22027011
TRPC3 |  | GLUT-4 | Co-immunoprecipitation | Mouse cardiomyocytes |  |  |  |  |  | 17156765
TRPC3 |  | Gơq/11 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | Gơq/11 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | Gz-ơ | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | Homer | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135
TRPC3 |  | IP3R1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | IP3R1 | Co-immunoprecipitation | Rat cerebral arterial lysates |  |  |  |  |  | 20378853
TRPC3 |  | IP3R1 | Co-immunoprecipitation | Rat mesenteric artery lysates |  |  |  |  |  | 23045459
TRPC3 |  | IP3R1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | IP3R1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Rat | Full-length | 10518223
TRPC3 |  | IP3R1 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | IP3R1 | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 20022948
TRPC3 |  | IP3R2 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | IP3R2 | Co-immunoprecipitation | Sheep uterine arterial endothelial cell |  |  |  |  |  | 16899571
TRPC3 |  | IP3R3 | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | IP3R3 | Co-immunofluorescence staining | Mouse pancreatic acini |  |  |  |  |  | 16887806
TRPC3 |  | IP3R3 | Co-immunofluorescence staining | Mouse parotid acini |  |  |  |  |  | 16887806
TRPC3 |  | IP3R3 | Co-immunofluorescence staining | Mouse submandibular gland duct |  |  |  |  |  | 16887806
TRPC3 |  | IP3R3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 14505576
TRPC3 |  | IP3R3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | IP3R3 | Co-immunoprecipitation | Mouse brain tissue |  |  |  |  |  | 16887806
TRPC3 |  | IP3R3 | Co-immunoprecipitation | Mouse pancreatic tissue |  |  |  |  |  | 16887806
TRPC3 |  | IP3R3 | Co-immunoprecipitation | Mouse submandibular gland lysates |  |  |  |  |  | 16887806
TRPC3 |  | IP3R3 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 10611319
TRPC3 |  | IP3R3 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | IP3R3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 10983988
TRPC3 |  | Junctophilin-2 | Co-immunoprecipitation |  | Mouse skeletal muscle myoblast lysates | Not used |  | Mouse | Full-length | 20095964
TRPC3 |  | Junctophilin-2 | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135
TRPC3 |  | MG29 | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135
TRPC3 |  | MxA | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 15757897
TRPC3 |  | NCX1 | Co-immunofluorescence staining | Rat myocyte section |  |  |  |  |  | 17012351
TRPC3 |  | NCX1 | Co-immunofluorescence staining | Rat cardiomyocytes |  |  |  |  |  | 17129578
TRPC3 |  | NCX1 | Co-immunofluorescence staining | dnTRPC3 TG mouse heart myocyte |  |  |  |  |  | 20351294
TRPC3 |  | NCX1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 14736881
TRPC3 |  | NCX1 | Co-immunoprecipitation |  | Sf9 | Mouse | Not specified | Rat | Not specified | 17012351
TRPC3 |  | NCX1 | Co-immunoprecipitation | Rat ventricle lysates |  |  |  |  |  | 17012351
TRPC3 |  | NCX1 | Co-immunoprecipitation | Rat cardiomyocytes |  |  |  |  |  | 17129578
TRPC3 |  | Neuromodulin | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | NKAơ1 | Co-immunofluorescence staining | Rat myocyte section |  |  |  |  |  | 17012351
TRPC3 |  | NKAơ1 | Co-immunoprecipitation | Rat ventricle lysates |  |  |  |  |  | 17012351
TRPC3 |  | NKAơ1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | ơ-actinin | Co-immunofluorescence staining | Rat ventricular myocytes |  |  |  |  |  | 24146259
TRPC3 |  | Orai1 | Co-immunoprecipitation |  | COS-7 | Human | Full-length | Human | Full-length | 17360584
TRPC3 |  | Orai1 | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 20022948
TRPC3 |  | Orai2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 22640869
TRPC3 |  | Orai2 | Co-immunoprecipitation |  | COS-7 | Human | Full-length | Human | Full-length | 17360584
TRPC3 |  | Orai3 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 22640869
TRPC3 |  | Orai3 | Co-immunoprecipitation |  | COS-7 | Human | Full-length | Human | Full-length | 17360584
TRPC3 |  | ơSNAP | Co-immunofluorescence staining | Rat hippocampal neuron |  |  |  |  |  | 15327778
TRPC3 |  | ơSNAP | Co-immunofluorescence staining | HSG cell |  |  |  |  |  | 15327778
TRPC3 |  | ơSNAP | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | ơSNAP | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | PDE3A | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not used |  | 21799177
TRPC3 |  | PKA | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not used |  | 21799177
TRPC3 |  | PKCƢ | Co-immunoprecipitation | DT40 |  |  |  |  |  | 20179100
TRPC3 |  | PLCƣ1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 19289841
TRPC3 |  | PLCƢ1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | PLCƣ1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Rat | Full-length | 21757714
TRPC3 |  | PLCƣ1 | Co-immunoprecipitation | Human erythroid cell |  |  |  |  |  | 18276585
TRPC3 |  | PLCƣ1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Rat | Full-length | 18276585
TRPC3 |  | PLCƣ1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Rat | Full-length | 12437926
TRPC3 |  | PLCƢ1 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | PLCƣ1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Rat | Full-length | 19074769
TRPC3 |  | PLCƣ2 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Chicken | Full-length | 12970180
TRPC3 |  | PLCƣ2 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Rat | Full-length | 19289841
TRPC3 |  | PLCƢ2 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | PLCƣ2 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Chicken | Full-length | 20179100
TRPC3 |  | PLCƢ3 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | PMCA | Co-immunoprecipitation | Mouse brain tissue |  |  |  |  |  | 16887806
TRPC3 |  | PMCA | Co-immunoprecipitation | Mouse pancreatic tissue |  |  |  |  |  | 16887806
TRPC3 |  | PMCA | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | RACK1 | Co-immunofluorescence staining |  | HEK293 | Not specified | Full-length | Not used |  | 18755685
TRPC3 |  | RACK1 | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not used |  | 18755685
TRPC3 |  | RACK1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18755685
TRPC3 |  | RNF24 | Co-immunofluorescence staining |  | HEK293 | Not specified | Full-length | Human | Full-length | 17850865
TRPC3 |  | RyR | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 10983988
TRPC3 |  | RyR2 | Co-immunofluorescence staining | Rat myocyte section |  |  |  |  |  | 17012351
TRPC3 |  | RyR2 | Co-immunoprecipitation | Rat ventricle lysates |  |  |  |  |  | 17012351
TRPC3 |  | SERCA2 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | SERCA2 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | SNAP23 | Co-immunofluorescence staining | Rat hippocampal neuron |  |  |  |  |  | 15327778
TRPC3 |  | SNAP23 | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | SNAP23 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | SRC | Co-immunoprecipitation |  | COS-7 | Mouse | Full-length | Chicken | Full-length | 16407161
TRPC3 |  | STIM1 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 22640869
TRPC3 |  | STIM1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 23068106
TRPC3 |  | STIM1 | Co-immunoprecipitation |  |  | Not specified | Full-length (mutant) | Human | Full-length | 24464579
TRPC3 |  | STIM2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 22640869
TRPC3 |  | Synaptotagmin 1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC3 |  | Syntaxin3 | Co-immunofluorescence staining | Rat hippocampal neuron |  |  |  |  |  | 15327778
TRPC3 |  | Syntaxin3 | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | Syntaxin3 | Co-immunoprecipitation | Rat hippocampal neuron |  |  |  |  |  | 15327778
TRPC3 |  | Syntaxin3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | Syntaxin3 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | TrkB | Co-immunofluorescence staining | Rat brain pontine neuron |  |  |  |  |  | 10677043
TRPC3 |  | TrkB | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 10677043
TRPC3 |  | TRPC1 | Co-immunoprecipitation | HSY cell |  |  |  |  |  | 15834157
TRPC3 |  | TRPC1 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 19260825
TRPC3 |  | TRPC1 | Co-immunoprecipitation | HEK293 |  |  |  |  |  | 15972814
TRPC3 |  | TRPC1 | Co-immunoprecipitation | Rat carotid artery smooth muscle cell |  |  |  |  |  | 19502552
TRPC3 |  | TRPC1 | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135
TRPC3 |  | TRPC1 | Co-immunoprecipitation | Mouse primary skeletal myotubes |  |  |  |  |  | 24613381
TRPC3 |  | TRPC1 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 9215637
TRPC3 |  | TRPC1 | Co-immunoprecipitation | C2C12 |  |  |  |  |  | 21996795
TRPC3 |  | TRPC1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 17486119
TRPC3 |  | TRPC1 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC3 |  | TRPC4 | Co-immunofluorescence staining | Porcine primary aortic endothelial cell |  |  |  |  |  | 16537542
TRPC3 |  | TRPC4 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC3 |  | TRPC4 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Mouse | Full-length | 16537542
TRPC3 |  | TRPC4 | Co-immunoprecipitation | Porcine primary aortic endothelial cell |  |  |  |  |  | 16537542
TRPC3 |  | TRPC4 | Co-immunoprecipitation | TRPC3 dnTRPC4 DTG mouse heart lysataes |  |  |  |  |  | 20351294
TRPC3 |  | TRPC5 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC3 |  | TRPC6 | Co-immunofluorescence staining | MDA-MB-231 |  |  |  |  |  | 19689790
TRPC3 |  | TRPC6 | Co-immunoprecipitation | dnTRPC6 Neonatal rat ventricular myocytes |  |  |  |  |  | 20351294
TRPC3 |  | TRPC6 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 19260825
TRPC3 |  | TRPC6 | Co-immunoprecipitation | MDA-MB-231 |  |  |  |  |  | 19689790
TRPC3 |  | TRPC6 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 12032305
TRPC3 |  | TRPC6 | Co-immunoprecipitation | Rat brain synaptome |  |  |  |  |  | 12377790
TRPC3 |  | TRPC6 | Co-immunoprecipitation |  | Sf9 | Human | Full-length | Mouse | Full-length | 12377790
TRPC3 |  | TRPC6 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 16270640
TRPC3 |  | TRPC6 | Co-immunoprecipitation |  | MDCK | Not specified | Full-length | Not used |  | 15623527
TRPC3 |  | TRPC6 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 19074769
TRPC3 |  | TRPC6 | Co-immunoprecipitation | TF-1 |  |  |  |  |  | 19074769
TRPC3 |  | TRPC6 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Human | Full-length | 12032305
TRPC3 |  | TRPC7 | Co-immunoprecipitation |  | Sf9 | Human | Full-length | Mouse | Full-length | 12377790
TRPC3 |  | TRPC7 | Co-immunoprecipitation | Rat brain synaptome |  |  |  |  |  | 12377790
TRPC3 |  | TRPC7 | Co-immunoprecipitation | Rat ventricular myocytes |  |  |  |  |  | 18502908
TRPC3 |  | TRPC7 | Co-immunoprecipitation |  | CHO | Human | Full-length | Mouse | 1-494 | 15537648
TRPC3 |  | TRPC7 | Fluorescence resonance energy transfer |  | HEK293 | Human | Full-length | Mouse | Full-length | 12032305
TRPC3 |  | TRPM4 | Co-immunofluorescence staining |  | HEK293T | Human | Full-length | Human | Full-length | 18262493
TRPC3 |  | TRPM4 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Human | Full-length | 18262493
TRPC3 |  | TRPP1 | Co-immunofluorescence staining |  | LLC-PK1 | Not used |  | Human | 1-697 | 19812035
TRPC3 |  | TRPP1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | 1-697 | 19812035
TRPC3 |  | VAMP2 | Co-immunofluorescence staining | Rat hippocampal neuron |  |  |  |  |  | 15327778
TRPC3 |  | VAMP2 | Co-immunofluorescence staining | HSG cell |  |  |  |  |  | 15327778
TRPC3 |  | VAMP2 | Co-immunofluorescence staining |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | VAMP2 | Co-immunoprecipitation | Rat hippocampal neuron |  |  |  |  |  | 15327778
TRPC3 |  | VAMP2 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 15327778
TRPC3 |  | WNK4 | Co-immunoprecipitation | Rat aorta lysates |  |  |  |  |  | 21670282
TRPC3 |  | WNK4 | Co-immunoprecipitation |  | HEK293T | Human | Full-length | Mouse | Full-length | 21670282

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | Calmodulin | Fluorescence probe labeling | Human | 764-793 | Bovine | Not determined |  | 100 nM | 11248050
TRPC3 |  | Calmodulin | Fluorescence probe labeling | Human | 764-793 | Not specified | Not determined |  | 100 nM | 11290752
TRPC3 |  | Calmodulin | Fusion protein-pull down assay | Human | 761-795 | Not specified | Not determined |  |  | 11290752
TRPC3 |  | Epo-R | Co-immunoprecipitation | Human | 671-746 | Human | Not determined |  |  | 19074769
TRPC3 |  | IP3R1 | Co-immunoprecipitation | Human | Not determined | Rat | IP3 binding domain |  |  | 10518223
TRPC3 |  | IP3R1 | Fusion protein-pull down assay | Mouse | 725-848 | Not specified | 654-688 |  |  | 11290752
TRPC3 |  | IP3R2 | Fusion protein-pull down assay | Mouse | 725-848 | Not specified | 675-695 |  |  | 11290752
TRPC3 |  | IP3R3 | Co-immunoprecipitation | Human | 775-787 | Rat | Not determined |  |  | 18276585
TRPC3 |  | IP3R3 | Fusion protein-pull down assay | Human | 761-795 | Human | 669-698 |  |  | 11248050
TRPC3 |  | IP3R3 | Fusion protein-pull down assay | Human | 761-795 | Human | 669-698 |  |  | 11290752
TRPC3 |  | IP3R3 | Fusion protein-pull down assay | Mouse | 725-848 | Human | 681-698 |  |  | 11290752
TRPC3 |  | IP3R3 | Fusion protein-pull down assay | Human | 777-797 | Human | 669-698 |  |  | 10611319
TRPC3 |  | IP3R3 | Fusion protein-pull down assay | Human | 777-797 | Human | 751-821 |  |  | 10611319
TRPC3 |  | Junctophilin-2 | Fusion protein-pull down assay | Mouse | Not determined | Mouse | 143-234 |  |  | 19277847
TRPC3 |  | MxA | Fusion protein-pull down assay | Human | 1-201 | Human | 572-662 |  |  | 15757897
TRPC3 |  | NCX1 | Fusion protein-pull down assay | Human | 670-848 | Rat | Not determined |  |  | 17129578
TRPC3 |  | PKCƢ | Fusion protein-pull down assay | Mouse | 659-836 | Chicken | Not determined |  |  | 20179100
TRPC3 |  | PLCƣ1 | Fusion protein-pull down assay | Human | 1-52 | Rat | 794-933 |  |  | 16500902
TRPC3 |  | PLCƣ1 | Fusion protein-pull down assay | Human | 40-48 | Rat | 861-920 |  |  | 15744307
TRPC3 |  | PLCƣ1 | Yeast two-hybrid | Human | 40-46 | Rat | 861-920 |  |  | 15744307
TRPC3 |  | PLCƣ1 | Yeast two-hybrid | Human | 1-340 | Rat | 780-920 |  |  | 12437926
TRPC3 |  | PLCƣ2 | Co-immunoprecipitation | Mouse | Not determined | Chicken | 810-829 |  |  | 12970180
TRPC3 |  | RACK1 | Yeast two-hybrid | Not specified | 221-342 | Human | Not determined |  |  | 18755685
TRPC3 |  | SRC | Co-immunoprecipitation | Mouse | 1-370 | Chicken | SH2 domain |  |  | 16407161
TRPC3 |  | TRPC1 | Yeast two-hybrid | Not specified | 1-341 | Not specified | 1-73 |  |  | 15834157
TRPC3 |  | TRPM4 | Co-immunoprecipitation | Human | Not determined | Human | 858-1188 |  |  | 18262493
TRPC3 |  | TRPP1 | Fusion protein-pull down assay | Mouse | 659-753 | Human | 1-697 |  |  | 19812035
TRPC3 |  | VAMP2 | Yeast two-hybrid | Human | 1-123 | Rat | Not determined |  |  | 15327778
TRPC3 |  | WNK4 | Co-immunoprecipitation | Human | 1-196 | Mouse | 441-799 |  |  | 21670282
TRPC3 |  | WNK4 | Co-immunoprecipitation | Human | 1-196 | Mouse | 441-1032 |  |  | 21670282

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPC3 |  | Calmodulin | Patch clamp |  |  | Inhibition | 11248050
TRPC3 |  | CaSR | Cell surface biotinylation |  | Increase in plasma membrane level |  | 22778254
TRPC3 |  | Epo-R | Calcium measurement |  |  | Activation | 18276585
TRPC3 |  | Epo-R | Patch clamp |  |  | Activation | 18276585
TRPC3 |  | Homer-1 | Cell surface biotinylation |  | Increase in plasma membrane level |  | 16887806
TRPC3 |  | Homer-1 | Patch clamp |  |  | Activation | 16887806
TRPC3 |  | IP3R1 | Calcium measurement |  |  | Activation | 10518223
TRPC3 |  | IP3R1 | Patch clamp |  |  | Activation | 10518223
TRPC3 |  | IP3R3 | Calcium measurement |  |  | Activation | 10611319
TRPC3 |  | IP3R3 | Calcium measurement |  |  | Inhibition | 10611319
TRPC3 |  | IP3R3 | Patch clamp |  |  | Activation | 11248050
TRPC3 |  | Junctate | Patch clamp |  |  | Activation | 15302852
TRPC3 |  | Orai1 | Patch clamp |  |  | Activation | 18287061
TRPC3 |  | PKG1 | In vitro PTM assay | Phosphorylation (Tyr-11) |  |  | 14983059
TRPC3 |  | PKG1 | In vitro PTM assay | Phosphorylation (Ser-263) |  |  | 14983059
TRPC3 |  | PLCƣ1 | Calcium measurement |  |  | Activation | 12437926
TRPC3 |  | PLCƣ1 | Calcium measurement |  |  | Activation | 15744307
TRPC3 |  | PLCƣ2 | Calcium measurement |  |  | Activation | 12970180
TRPC3 |  | PLCƣ2 | Patch clamp |  |  | Activation | 12970180
TRPC3 |  | RNF24 | Cell surface biotinylation |  | Decrease in plasma membrane level |  | 17850865
TRPC3 |  | RyR | Patch clamp |  |  | Activation | 10983988
TRPC3 |  | SRC | Calcium measurement |  |  | Activation | 16407161
TRPC3 |  | SRC | In vivo PTM assay | Phosphorylation (Tyr-226) |  |  | 16407161
TRPC3 |  | TRPC1 | Patch clamp |  |  | New channel creation | 10882720
TRPC3 |  | TRPM4 | Patch clamp |  |  | Inhibition | 18262493
TRPC3 |  | TRPP1 | Calcium measurement |  |  | Activation | 19812035
TRPC3 |  | WNK4 | Cell surface biotinylation |  | Decrease in plasma membrane level |  | 21670282
TRPC3 |  | WNK4 | Ion influx measurement |  |  | Inhibition | 21670282

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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