# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# SERCA2 / TRP channels

- Basic Information
- External Database
- PPI pairs (4)
- Biological Process (10)
- Disease (2)

Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2)
Official Symbol: ATP2A2 provided by HGNC
Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 488 | P16615 | DIP-33868N | P16615 | MINT-4991144 | 106978 | P16615 |  | hsa:488 | 108740
Mouse | 11938 | O55143 | DIP-32223N | O55143 | MINT-1853527 | 198249 | O55143 |  | mmu:11938 |
Rat | 29693 | P11507 | DIP-36967N | P11507 | MINT-4563897 | 248313 | P11507 |  | rno:29693 |

PPI pairs:

TRPC1 | TRPC3 | TRPC6 | TRPP1

Biological Process:

- GO:0006754 : ATP biosynthetic process
- GO:0007596 : blood coagulation
- GO:0007155 : cell adhesion
- GO:0006874 : cellular calcium ion homeostasis
- GO:0008544 : epidermis development
- GO:0006984 : ER-nucleus signaling pathway
- GO:0045822 : negative regulation of heart contraction
- GO:0002026 : regulation of the force of heart contraction
- GO:0043434 : response to peptide hormone stimulus
- GO:0070296 : sarcoplasmic reticulum calcium ion transport

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:108740 : Darier disease (OMIM:124200 )
- OMIM:108740 : Acrokeratosis verruciformis (OMIM:101900 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC1 |  | SERCA2 | Inference |  |  |  |  |  | Prediction | 18068335
TRPC3 |  | SERCA2 | Affinity purification-mass spectrometry | Not used as a bait |  | Rat | Brain | Crude membranes |  | 18205297
TRPC3 |  | SERCA2 | Inference |  |  |  |  |  | Prediction | 11524429
TRPC6 |  | SERCA2 | Inference |  |  |  |  |  | Prediction | 18191041
TRPP1 |  | SERCA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC1 |  | SERCA2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18068335
TRPC1 |  | SERCA2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18191041
TRPC3 |  | SERCA2 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Not used |  | 11524429
TRPC3 |  | SERCA2 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 18205297
TRPC6 |  | SERCA2 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 18191041

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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