# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPC5 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (59)
- Biological Process (1)
- Disease (0)

Name: Short transient receptor potential channel 5 (TRPC5)
Official Symbol: TRPC5 provided by HGNC
Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 7224 | Q9UL62 | DIP-35696N | Q9UL62 | MINT-3082029 | 113075 | Q9UL62 | 490 | hsa:7224 | 300334
Mouse | 22067 | Q9QX29 | DIP-40847N |  | MINT-144678 | 204331 | Q9QX29 |  | mmu:22067 |
Rat | 140933 | Q8VD38 |  |  |  | 250867 | Q8VD38 |  | rno:140933 |

PPI pairs:

AP2B1 | CAND1 | CaBP1 | CaMKIIƢ | Calmodulin | Cav1.2 | Clathrin-H1 | D2R
Drebrin | Dynamin-1 | EF2 | Enkurin | FKBP52/FKBP4 | Gơi3 | Homer-1 | Homer-3
IP3R3 | Junctate | MxA | Myosin-10 | Myosin-5a | Myosin-HIIA | NCS-1 | NHERF1
NKAơ1 | NKAơ3 | Neurabin-1 | Neurabin-2 | OGDH | RNF24 | RyR1 | SEC31A
SESTD1 | SNAP91 | SRA-1 | STIM1 | Src | Stathmin1 | Stathmin2 | Stathmin3
Stathmin4 | TARBP2 | TRF1 | TRF2 | TRPC1 | TRPC3 | TRPC4 | TRPC6
TRPC7 | TUBGCP2 | TUBGCP3 | UBC | ơ-actinin | ơ-actinin-1 | ơ-actinin-4 | ơ2-actin
ơII-spectrin | ƢII-spectrin | ƢIII-spectrin

Biological Process:

- GO:0007411 : axon guidance

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC5 |  | AP2B1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | CaBP1 | Inference |  |  |  |  |  | Prediction | 15895247
TRPC5 |  | Calmodulin | Inference |  |  |  |  |  | Prediction | 11290752
TRPC5 |  | CaMKIIƢ | Inference |  |  |  |  |  | Prediction | 22135323
TRPC5 |  | CAND1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Cav1.2 | Inference |  |  |  |  |  | Prediction | 21672930
TRPC5 |  | Clathrin-H1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | D2R | Inference |  |  |  |  |  | Prediction | 18261457
TRPC5 |  | Drebrin | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Dynamin-1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | EF2 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Enkurin | Inference |  |  |  |  |  | Prediction | 15385169
TRPC5 |  | FKBP52/FKBP4 | Inference |  |  |  |  |  | Prediction | 15199065
TRPC5 |  | Gơi3 | Inference |  |  |  |  |  | Prediction | 22457348
TRPC5 |  | ƢII-spectrin | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | ƢIII-spectrin | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Homer-1 | Inference |  |  |  |  |  | Prediction | 14505576
TRPC5 |  | Homer-3 | Inference |  |  |  |  |  | Prediction | 14505576
TRPC5 |  | IP3R3 | Inference |  |  |  |  |  | Prediction | 11290752
TRPC5 |  | Junctate | Inference |  |  |  |  |  | Prediction | 16153633
TRPC5 |  | MxA | Inference |  |  |  |  |  | Prediction | 15757897
TRPC5 |  | Myosin-10 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Myosin-5a | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Myosin-HIIA | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | NCS-1 | Inference |  |  |  |  |  | Prediction | 16469785
TRPC5 |  | Neurabin-1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | Neurabin-2 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | NHERF1 | Inference |  |  |  |  |  | Prediction | 10980202
TRPC5 |  | NKAơ1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | NKAơ3 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | ơ-actinin | Speculation |  |  |  |  |  | Prediction | 16025302
TRPC5 |  | ơ-actinin-1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | ơ-actinin-4 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | ơ2-actin | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | OGDH | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | ơII-spectrin | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | RNF24 | Inference |  |  |  |  |  | Prediction | 17850865
TRPC5 |  | RyR1 | Affinity purification-mass spectrometry | Not used as a bait |  | Rabbit | Fast-twitch muscle | Triad vesicles |  | 18215135
TRPC5 |  | SEC31A | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | SESTD1 | Inference |  |  |  |  |  | Prediction | 20164195
TRPC5 |  | SNAP91 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | SRA-1 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | SRC | Inference |  |  |  |  |  | Prediction | 16407161
TRPC5 |  | Stathmin1 | Inference |  |  |  |  |  | Prediction | 12858178
TRPC5 |  | Stathmin2 | Inference |  |  |  |  |  | Prediction | 12858178
TRPC5 |  | Stathmin3 | Yeast two-hybrid | Mouse | 1-333 | Rat | Brain | cDNA library |  | 12858178
TRPC5 |  | Stathmin4 | Inference |  |  |  |  |  | Prediction | 12858178
TRPC5 |  | STIM1 | Inference |  |  |  |  |  | Prediction | 16906149
TRPC5 |  | TARBP2 | Inference |  |  |  |  |  | Prediction | 24563462
TRPC5 |  | TRF1 | Affinity purification-mass spectrometry | Not used as a bait |  | Human | HEK293T | Cell lystaes |  | 20811636
TRPC5 |  | TRF2 | Affinity purification-mass spectrometry | Not used as a bait |  | Human | HEK293T | Cell lystaes |  | 20811636
TRPC5 |  | TRPC1 | Inference |  |  |  |  |  | Prediction | 11301024
TRPC5 |  | TRPC3 | Inference |  |  |  |  |  | Prediction | 12857742
TRPC5 |  | TRPC4 | Inference |  |  |  |  |  | Prediction | 12032305
TRPC5 |  | TRPC6 | Inference |  |  |  |  |  | Prediction | 12857742
TRPC5 |  | TRPC7 | Inference |  |  |  |  |  | Prediction | 18356201
TRPC5 |  | TUBGCP2 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | TUBGCP3 | Affinity purification-mass spectrometry | Endogenous protein |  | Rat | Brain | Cerebral cortex lysates |  | 16025302
TRPC5 |  | UBC | Affinity purification-mass spectrometry | Not used as a bait |  | Human | U2OS osteosarcoma | Cell lystaes |  | 21139048

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vitro validation
| Assay with recombinant proteins | Reference
--- | --- | ---
TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Expression system | Species | Region | Expression system
TRPC5 |  | CaBP1 | Fusion protein-pull down assay | Mouse | Full-length | E. coli | Human | Full-length | E. coli | 15895247
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 1-331 | In vitro translation | Not specified | Not specified | Not specified | 15987684
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 701-807 | In vitro translation | Not specified | Not specified | Not specified | 15987684
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 762-975 | In vitro translation | Not specified | Not specified | Not specified | 15987684
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 1-321 | In vitro translation | Not specified | Full-length | E. coli | 12601176
TRPC5 |  | D2R | Fusion protein-pull down assay | Human | 619-973 | E. coli | Human | 131-151 | E. coli | 18261457
TRPC5 |  | Enkurin | Fusion protein-pull down assay | Mouse | Full-length | E. coli | Mouse | Full-length | HEK293 lysates | 15385169
TRPC5 |  | Enkurin | Yeast two-hybrid | Mouse | N-terminus | Yeast | Mouse | Full-length | Yeast | 15385169
TRPC5 |  | FKBP52/FKBP4 | Co-immunoprecipitation | Mouse | Full-length | Sf9 lysates | Human | Full-length | Sf9 lysates | 15199065
TRPC5 |  | Gơi3 | Fusion protein-pull down assay | Human | Full | E. coli | Human | Full | E. coli | 22457348
TRPC5 |  | Junctate | Fusion protein-pull down assay | Not specified | Full-length | HEK293 lysates | Mouse | Full-length | In vitro translation | 16153633
TRPC5 |  | MxA | Fusion protein-pull down assay | Human | 1-183 | In vitro translation | Human | 572-662 | E. coli | 15757897
TRPC5 |  | NCS-1 | Fusion protein-pull down assay | Human | 619-973 | E. coli | Human | Full-length | E. coli | 16469785
TRPC5 |  | NCS-1 | Yeast two-hybrid | Human | 619-973 | Yeast | Human | Full-length | Yeast | 16469785
TRPC5 |  | NHERF1 | Fusion protein-pull down assay | Mouse | Full-length | In vitro translation | Mouse | 1-107 | E. coli | 10980202
TRPC5 |  | RNF24 | Fusion protein-pull down assay | Not specified | 1-183 | In vitro translation | Human | 98-148 | E. coli | 17850865
TRPC5 |  | SRC | Fusion protein-pull down assay | Mouse | 630-975 | In vitro translation | Chicken | Full-length | E. coli | 16407161
TRPC5 |  | SRC | Fusion protein-pull down assay | Mouse | 1-321 | In vitro translation | Chicken | Full-length | E. coli | 16407161
TRPC5 |  | Stathmin3 | Fusion protein-pull down assay | Not specified | Full-length | In vitro translation | Not specified | Full-length | In vitro translation | 12858178

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC5 |  | CaMKIIƢ | Co-immunoprecipitation | Whole-brain lysates |  |  |  |  |  | 22135323
TRPC5 |  | CaMKIIƢ | Co-immunoprecipitation |  | HEK293T | Mouse | Full-length | Rat | Full-length | 22135323
TRPC5 |  | CaMKIIƢ | Co-immunoprecipitation | cortical neurons |  |  |  |  |  | 22135323
TRPC5 |  | Cav1.2 | Co-immunoprecipitation | Chick embryonic heart lysates |  |  |  |  |  | 21672930
TRPC5 |  | Clathrin-H1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC5 |  | Drebrin | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC5 |  | Dynamin-1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC5 |  | FKBP52/FKBP4 | Co-immunoprecipitation | Rat cerebral cortex |  |  |  |  |  | 15199065
TRPC5 |  | Gơi3 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 22457348
TRPC5 |  | Gơi3 | Co-immunoprecipitation | Rat brain extract |  |  |  |  |  | 22457348
TRPC5 |  | Homer-1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 14505576
TRPC5 |  | Homer-3 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 14505576
TRPC5 |  | IP3R3 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 14505576
TRPC5 |  | NCS-1 | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 16469785
TRPC5 |  | NCS-1 | Co-immunoprecipitation | Rat brain membrane lysates |  |  |  |  |  | 16469785
TRPC5 |  | NKAơ1 | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC5 |  | ơ-actinin | Co-immunofluorescence staining | Rat ventricular myocytes |  |  |  |  |  | 24146259
TRPC5 |  | ơ-actinin | Co-immunoprecipitation | Rat brain lysates |  |  |  |  |  | 16025302
TRPC5 |  | SESTD1 | Co-immunoprecipitation |  | HEK293-HM1 stable cell line | Mouse | Full-length | Human | Full-length | 20164195
TRPC5 |  | Stathmin1 | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not specified | Full-length | 12858178
TRPC5 |  | Stathmin2 | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not specified | Full-length | 12858178
TRPC5 |  | Stathmin3 | Co-immunoprecipitation |  | HEK293T | Not specified | Full-length | Not specified | Full-length | 12858178
TRPC5 |  | Stathmin4 | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not specified | Full-length | 12858178
TRPC5 |  | STIM1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 16906149
TRPC5 |  | STIM1 | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Human | Full-length | 24464579
TRPC5 |  | STIM1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 17486119
TRPC5 |  | STIM1 | Co-immunoprecipitation |  | HEK293T | Rat | Full-length | Rat | Full-length | 22201561
TRPC5 |  | TARBP2 | Co-immunoprecipitation |  | HEK293 | Not specified | Not specified | Mouse | Full-length | 24563462
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 11301024
TRPC5 |  | TRPC1 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Human | Full-length | 11301024
TRPC5 |  | TRPC1 | Co-immunoprecipitation |  | Sf9 | Mouse | Full-length | Human | Full-length | 12377790
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Rat brain synaptome |  |  |  |  |  | 12377790
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Rabbit coronary artery |  |  |  |  |  | 18356201
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Rabbit mesenteric artery |  |  |  |  |  | 18356201
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Rabbit portal vein |  |  |  |  |  | 18356201
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 16270640
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Mouse vascular smooth muscle cell |  |  |  |  |  | 21968068
TRPC5 |  | TRPC1 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC5 |  | TRPC1 | Fluorescence resonance energy transfer |  | HEK293 | Mouse | Full-length | Human | Full-length | 12032305
TRPC5 |  | TRPC3 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC5 |  | TRPC4 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 12032305
TRPC5 |  | TRPC4 | Co-immunoprecipitation |  | Sf9 | Mouse | Full-length | Bovine | Full-length | 12377790
TRPC5 |  | TRPC4 | Co-immunoprecipitation | Rat brain synaptome |  |  |  |  |  | 12377790
TRPC5 |  | TRPC4 | Co-immunoprecipitation | Human platelets |  |  |  |  |  | 16270640
TRPC5 |  | TRPC4 | Fluorescence resonance energy transfer |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 12032305
TRPC5 |  | TRPC4 | Fluorescence resonance energy transfer |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 17624425
TRPC5 |  | TRPC6 | Co-immunoprecipitation | Rabbit coronary artery |  |  |  |  |  | 18356201
TRPC5 |  | TRPC6 | Co-immunoprecipitation | Rat brain microsome |  |  |  |  |  | 12857742
TRPC5 |  | TRPC7 | Co-immunoprecipitation | Rabbit portal vein |  |  |  |  |  | 18356201

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Characterization
| Binding region mapping | Stoichiometry | Affinity (Kd) | Reference
--- | --- | --- | --- | ---
TRP channel | Interactor
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC5 |  | CaBP1 | Fusion protein-pull down assay | Mouse | 1-331 | Human | Not determined |  |  | 15895247
TRPC5 |  | CaBP1 | Fusion protein-pull down assay | Mouse | 721-817 | Human | Not determined |  |  | 15895247
TRPC5 |  | CaBP1 | Fusion protein-pull down assay | Mouse | 791-866 | Human | Not determined |  |  | 15895247
TRPC5 |  | Calmodulin | Fluorescence probe labeling | Mouse | 702-731 | Not specified | Not determined |  | 220 nM | 11290752
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 701-733 | Bovine | Not determined |  |  | 15987684
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 828-854 | Bovine | Not determined |  |  | 15987684
TRPC5 |  | Calmodulin | Fusion protein-pull down assay | Mouse | 701-733 | Not specified | Not determined |  |  | 11290752
TRPC5 |  | CaMKIIƢ | Co-immunoprecipitation | Mouse | N-terminus | Rat | Not determined |  |  | 22135323
TRPC5 |  | CaMKIIƢ | Co-immunoprecipitation | Mouse | Not determined | Rat | C-terminus |  |  | 22135323
TRPC5 |  | D2R | Yeast two-hybrid | Human | 719-738 | Human | 131-151 |  |  | 18261457
TRPC5 |  | Gơi3 | Co-immunoprecipitation | Human | Not determined | Human | Not determined |  |  | 22457348
TRPC5 |  | IP3R3 | Fusion protein-pull down assay | Mouse | 701-733 | Human | 669-698 |  |  | 11290752
TRPC5 |  | MxA | Fusion protein-pull down assay | Human | 1-183 | Human | 572-662 |  |  | 15757897
TRPC5 |  | NCS-1 | Fusion protein-pull down assay | Human | 619-803 | Human | Not determined |  |  | 16469785
TRPC5 |  | NCS-1 | Fusion protein-pull down assay | Human | 803-973 | Human | Not determined |  |  | 16469785
TRPC5 |  | NCS-1 | Yeast two-hybrid | Human | 619-803 | Human | Not determined |  |  | 16469785
TRPC5 |  | NCS-1 | Yeast two-hybrid | Human | 803-973 | Human | Not determined |  |  | 16469785
TRPC5 |  | NHERF1 | Fusion protein-pull down assay | Mouse | 648-975 | Mouse | 1-107 |  |  | 10980202
TRPC5 |  | SESTD1 | Fusion protein-pull down assay | Mouse | 707-735 | Human | 193-406 |  |  | 20164195
TRPC5 |  | STIM1 | Co-immunoprecipitation | Rat | Not determined | Rat | 1798-1887 |  |  | 22201561
TRPC5 |  | TRPC4 | Fluorescence resonance energy transfer | Mouse | 1-308 | Mouse | 1-292 |  |  | 17624425

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPC5 |  | CaBP1 | Patch clamp |  |  | Inhibition | 15895247
TRPC5 |  | Gơi3 | Patch clamp |  |  | Activation | 22457348
TRPC5 |  | NCS-1 | Calcium measurement |  |  | Activation | 16469785
TRPC5 |  | NCS-1 | Patch clamp |  |  | Activation | 16469785
TRPC5 |  | SESTD1 | Calcium measurement |  |  | Activation | 20164195
TRPC5 |  | TRPC1 | Patch clamp |  |  | New channel creation | 11301024
TRPC5 |  | TRPC1 | Patch clamp |  |  | New channel creation | 12857742

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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