# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# RPS27A / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (51)
- Disease (0)

Name: Ubiquitin-40S ribosomal protein S27a (RPS27A)
Official Symbol: RPS27A provided by HGNC
Function:
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 6233 | P62979 | DIP-33063N | P62979 | MINT-1138719 | 112147 | P62979 |  | hsa:6233 | 191343
Mouse | 78294 | P62983 |  | P62983 |  | 219309 | P62983 |  | mmu:78294 |
Rat | 81777 100363345 | P62982 |  | P62982 |  | 249649 | P62982 |  | rno:81777 rno:100363345 |

PPI pairs:

TRPV4

Biological Process:

- GO:0000187 : activation of MAPK activity
- GO:0031145 : anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- GO:0002479 : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- GO:0006915 : apoptotic process
- GO:0016044 : cellular membrane organization
- GO:0019221 : cytokine-mediated signaling pathway
- GO:0006977 : DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- GO:0006281 : DNA repair
- GO:0046788 : egress of virus within host cell
- GO:0016197 : endosomal transport
- GO:0007173 : epidermal growth factor receptor signaling pathway
- GO:0008543 : fibroblast growth factor receptor signaling pathway
- GO:0000080 : G1 phase of mitotic cell cycle
- GO:0000082 : G1/S transition of mitotic cell cycle
- GO:0007249 : I-kappaB kinase/NF-kappaB cascade
- GO:0045087 : innate immune response
- GO:0007254 : JNK cascade
- GO:0000216 : M/G1 transition of mitotic cell cycle
- GO:0002755 : MyD88-dependent toll-like receptor signaling pathway
- GO:0042059 : negative regulation of epidermal growth factor receptor signaling pathway
- GO:0000122 : negative regulation of transcription from RNA polymerase II promoter
- GO:0030512 : negative regulation of transforming growth factor beta receptor signaling pathway
- GO:0032480 : negative regulation of type I interferon production
- GO:0051436 : negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- GO:0048011 : nerve growth factor receptor signaling pathway
- GO:0007220 : Notch receptor processing
- GO:0007219 : Notch signaling pathway
- GO:0000184 : nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- GO:0070423 : nucleotide-binding oligomerization domain containing signaling pathway
- GO:0043123 : positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0051092 : positive regulation of NF-kappaB transcription factor activity
- GO:0045944 : positive regulation of transcription from RNA polymerase II promoter
- GO:0051437 : positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- GO:0000209 : protein polyubiquitination
- GO:0042981 : regulation of apoptotic process
- GO:0061418 : regulation of transcription from RNA polymerase II promoter in response to hypoxia
- GO:0000084 : S phase of mitotic cell cycle
- GO:0006614 : SRP-dependent cotranslational protein targeting to membrane
- GO:0050852 : T cell receptor signaling pathway
- GO:0008063 : Toll signaling pathway
- GO:0034130 : toll-like receptor 1 signaling pathway
- GO:0034134 : toll-like receptor 2 signaling pathway
- GO:0034138 : toll-like receptor 3 signaling pathway
- GO:0034142 : toll-like receptor 4 signaling pathway
- GO:0006367 : transcription initiation from RNA polymerase II promoter
- GO:0007179 : transforming growth factor beta receptor signaling pathway
- GO:0006414 : translational elongation
- GO:0006413 : translational initiation
- GO:0006415 : translational termination
- GO:0035666 : TRIF-dependent toll-like receptor signaling pathway
- GO:0019083 : viral transcription

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV4 |  | RPS27A | Affinity purification-mass spectrometry | Mouse | Full-length | Human | HEK293 | Cell lystaes |  | 22492541

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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