# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# HCK / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (26)
- Disease (0)

Name: Tyrosine-protein kinase HCK (HCK)
Official Symbol: HCK provided by HGNC
Function:
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 3055 | P08631 | DIP-1051N | P08631 | MINT-135300 | 109305 | P08631 |  | hsa:3055 | 142370
Mouse | 15162 | P08103 | DIP-57107N |  | MINT-4097288 | 200249 | P08103 |  | mmu:15162 |
Rat | 25734 | P50545 |  |  | MINT-4592593 | 247762 | P50545 |  | rno:25734 |

PPI pairs:

TRPV4

Biological Process:

- GO:0007155 : cell adhesion
- GO:0050830 : defense response to Gram-positive bacterium
- GO:0006954 : inflammatory response
- GO:0002758 : innate immune response-activating signal transduction
- GO:0007229 : integrin-mediated signaling pathway
- GO:0060333 : interferon-gamma-mediated signaling pathway
- GO:0043299 : leukocyte degranulation
- GO:0002522 : leukocyte migration involved in immune response
- GO:0031663 : lipopolysaccharide-mediated signaling pathway
- GO:0007498 : mesoderm development
- GO:0043066 : negative regulation of apoptotic process
- GO:0018108 : peptidyl-tyrosine phosphorylation
- GO:0006909 : phagocytosis
- GO:2000251 : positive regulation of actin cytoskeleton reorganization
- GO:0030838 : positive regulation of actin filament polymerization
- GO:0008284 : positive regulation of cell proliferation
- GO:0046777 : protein autophosphorylation
- GO:0008360 : regulation of cell shape
- GO:0050690 : regulation of defense response to virus by virus
- GO:0050727 : regulation of inflammatory response
- GO:0050764 : regulation of phagocytosis
- GO:0071801 : regulation of podosome assembly
- GO:0051090 : regulation of sequence-specific DNA binding transcription factor activity
- GO:0045728 : respiratory burst after phagocytosis
- GO:0016032 : viral reproduction
- GO:0019048 : virus-host interaction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV4 |  | HCK | Inference |  |  |  |  |  | Prediction | 12538589

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV4 |  | HCK | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 12538589

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPV4 |  | HCK | Calcium measurement |  |  | Activation | 12538589
TRPV4 |  | HCK | In vitro PTM assay | Phosphorylation (Tyr-273) |  |  | 12538589

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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