# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# AQP-2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (19)
- Disease (1)

Name: Aquaporin-2 (AQP-2)
Official Symbol: AQP2 provided by HGNC
Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 359 | P41181 |  |  | MINT-7890724 | 106855 | P41181 |  | hsa:359 | 107777
Mouse | 11827 | P56402 | DIP-58509N |  | MINT-7890581 | 198171 | P56402 |  | mmu:11827 |
Rat | 25386 | P34080 | DIP-46223N |  |  | 247424 | P34080 |  | rno:25386 |

PPI pairs:

TRPC3

Biological Process:

- GO:0030042 : actin filament depolymerization
- GO:0007568 : aging
- GO:0006915 : apoptotic process
- GO:0006884 : cell volume homeostasis
- GO:0071280 : cellular response to copper ion
- GO:0071288 : cellular response to mercury ion
- GO:0042631 : cellular response to water deprivation
- GO:0007588 : excretion
- GO:0007565 : female pregnancy
- GO:0006972 : hyperosmotic response
- GO:0072205 : metanephric collecting duct development
- GO:0051928 : positive regulation of calcium ion transport
- GO:0003097 : renal water transport
- GO:0051592 : response to calcium ion
- GO:0033762 : response to glucagon stimulus
- GO:0032496 : response to lipopolysaccharide
- GO:0010226 : response to lithium ion
- GO:0009651 : response to salt stress
- GO:0042594 : response to starvation

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:107777 : Diabetes insipidus, nephrogenic (OMIM:125800 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | AQP-2 | Inference |  |  |  |  |  | Prediction | 17699554

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | AQP-2 | Co-immunofluorescence staining | Rat kidney medullary collecting duct |  |  |  |  |  | 20107112
TRPC3 |  | AQP-2 | Co-immunofluorescence staining | Rat kidney duct section |  |  |  |  |  | 17699554
TRPC3 |  | AQP-2 | Co-immunoprecipitation | mIMCD-3 |  |  |  |  |  | 17699554
TRPC3 |  | AQP-2 | Co-immunoprecipitation | Rat medulla lysates |  |  |  |  |  | 17699554

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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