# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Nephrin / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (8)
- Disease (1)

Name: Nephrin (Nephrin)
Official Symbol: NPHS1 provided by HGNC
Function:
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 4868 | O60500 | DIP-36424N | O60500 |  | 110928 | O60500 |  | hsa:4868 | 602716
Mouse | 54631 | Q9QZS7 |  |  |  | 207694 | Q9QZS7 |  | mmu:54631 |
Rat | 64563 | Q9R044 |  |  | MINT-8384233 | 249144 | Q9R044 |  | rno:64563 |

PPI pairs:

TRPC6

Biological Process:

- GO:0007155 : cell adhesion
- GO:0007588 : excretion
- GO:0032836 : glomerular basement membrane development
- GO:0072015 : glomerular visceral epithelial cell development
- GO:0007254 : JNK cascade
- GO:0007520 : myoblast fusion
- GO:0030838 : positive regulation of actin filament polymerization
- GO:0044062 : regulation of excretion

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:602716 : Nephrotic syndrome, type 1 (OMIM:256300 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC6 |  | Nephrin | Inference |  |  |  |  |  | Prediction | 15924139

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC6 |  | Nephrin | Co-immunofluorescence staining |  | Mouse podocytes section | Mouse | Full-length | Not used |  | 15924139
TRPC6 |  | Nephrin | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 15924139
TRPC6 |  | Nephrin | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 15924139
TRPC6 |  | Nephrin | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Mouse | Full-length | 22155451
TRPC6 |  | Nephrin | Co-immunoprecipitation | Mouse podocyte lysates |  |  |  |  |  | 22155451

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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