# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRPA1 / interactors

- At a glance
- In detail

- Basic Information
- External Database
- PPI pairs (8)
- Biological Process (8)
- Disease (0)

Name: Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Official Symbol: TRPA1 provided by HGNC
Function:
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 8989 | O75762 |  |  |  | 114471 | O75762 | 485 | hsa:8989 | 604775
Mouse | 277328 | Q8BLA8 |  |  |  | 234929 | Q8BLA8 |  | mmu:277328 |
Rat | 312896 | Q6RI86 |  |  |  | 260269 | Q6RI86 |  | rno:312896 |

PPI pairs:

AKAP5/AKAP150 | CYLD | Orai1 | STIM1 | Secretogranin3 | TRPC1 | TRPC6 | TRPV1

Biological Process:

- GO:0050968 : detection of chemical stimulus involved in sensory perception of pain
- GO:0050966 : detection of mechanical stimulus involved in sensory perception of pain
- GO:0006811 : ion transport
- GO:0009409 : response to cold
- GO:0042493 : response to drug
- GO:0042542 : response to hydrogen peroxide
- GO:0048265 : response to pain
- GO:0050955 : thermoception

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPA1 |  | AKAP5/AKAP150 | Speculation |  |  |  |  |  | Prediction | 18701070
TRPA1 |  | CYLD | Inference |  |  |  |  |  | Prediction | 16500080
TRPA1 |  | Orai1 | Inference |  |  |  |  |  | Prediction | 23994313
TRPA1 |  | Secretogranin3 | Yeast two-hybrid | Rat | N-terminus | Rat | Brain | cDNA library |  | 18802106
TRPA1 |  | STIM1 | Inference |  |  |  |  |  | Prediction | 23994313
TRPA1 |  | TRPC1 | Inference |  |  |  |  |  | Prediction | 23994313
TRPA1 |  | TRPC6 | Inference |  |  |  |  |  | Prediction | 23994313
TRPA1 |  | TRPV1 | Inference |  |  |  |  |  | Prediction | 20231274

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPA1 |  | AKAP5/AKAP150 | Co-immunoprecipitation |  | HEK293 | Mouse | Full-length | Not used |  | 18701070
TRPA1 |  | CYLD | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 16500080
TRPA1 |  | CYLD | Co-immunoprecipitation |  | MDA-MB-435 | Not used |  | Human | Full-length | 16500080
TRPA1 |  | CYLD | Co-immunoprecipitation | Human Jurkat T cell |  |  |  |  |  | 16500080
TRPA1 |  | Orai1 | Co-immunoprecipitation | MEG-01 |  |  |  |  |  | 23994313
TRPA1 |  | Secretogranin3 | Co-immunoprecipitation | RBL-2H3 |  |  |  |  |  | 18802106
TRPA1 |  | STIM1 | Co-immunoprecipitation | MEG-01 |  |  |  |  |  | 23994313
TRPA1 |  | TRPC1 | Co-immunoprecipitation | MEG-01 |  |  |  |  |  | 23994313
TRPA1 |  | TRPC6 | Co-immunoprecipitation | MEG-01 |  |  |  |  |  | 23994313
TRPA1 |  | TRPV1 | Co-immunoprecipitation |  | CHO | Mouse | Full-length | Rat | Full-length | 20231274
TRPA1 |  | TRPV1 | Co-immunoprecipitation | Mouse trigeminal ganglia lysates |  |  |  |  |  | 20231274

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPA1 |  | CYLD | In vivo PTM assay | De-ubiquitination |  |  | 16500080

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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