# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# Calreticulin / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (34)
- Disease (0)

Name: Calreticulin (Calreticulin)
Official Symbol: CALR provided by HGNC
Function:
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 811 | P27797 | DIP-104N | P27797 | MINT-101756 | 107262 | P27797 |  | hsa:811 | 109091
Mouse | 12317 | P14211 | DIP-38086N | P14211 | MINT-1679870 | 198458 | P14211 |  | mmu:12317 |
Rat | 64202 | P18418 | DIP-37224N | P18418 | MINT-245423 | 249008 | P18418 |  | rno:64202 |

PPI pairs:

TRPC3

Biological Process:

- GO:0006987 : activation of signaling protein activity involved in unfolded protein response
- GO:0002479 : antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- GO:0055007 : cardiac muscle cell differentiation
- GO:0007050 : cell cycle arrest
- GO:0071285 : cellular response to lithium ion
- GO:0090398 : cellular senescence
- GO:0030866 : cortical actin cytoskeleton organization
- GO:0042921 : glucocorticoid receptor signaling pathway
- GO:0033144 : negative regulation of intracellular steroid hormone receptor signaling pathway
- GO:0045665 : negative regulation of neuron differentiation
- GO:0048387 : negative regulation of retinoic acid receptor signaling pathway
- GO:0000122 : negative regulation of transcription from RNA polymerase II promoter
- GO:0017148 : negative regulation of translation
- GO:0002502 : peptide antigen assembly with MHC class I protein complex
- GO:0045787 : positive regulation of cell cycle
- GO:0008284 : positive regulation of cell proliferation
- GO:2000510 : positive regulation of dendritic cell chemotaxis
- GO:0045740 : positive regulation of DNA replication
- GO:0010628 : positive regulation of gene expression
- GO:0050766 : positive regulation of phagocytosis
- GO:1900026 : positive regulation of substrate adhesion-dependent cell spreading
- GO:0043687 : post-translational protein modification
- GO:0006611 : protein export from nucleus
- GO:0034504 : protein localization to nucleus
- GO:0022417 : protein maturation by protein folding
- GO:0018279 : protein N-linked glycosylation via asparagine
- GO:0050821 : protein stabilization
- GO:0042981 : regulation of apoptotic process
- GO:0040020 : regulation of meiosis
- GO:0042493 : response to drug
- GO:0032355 : response to estradiol stimulus
- GO:0033574 : response to testosterone stimulus
- GO:0051208 : sequestering of calcium ion
- GO:0007283 : spermatogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC3 |  | Calreticulin | Inference |  |  |  |  |  | Prediction | 18215135

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPC3 |  | Calreticulin | Co-immunoprecipitation | Mouse skeletal myotube lysates |  |  |  |  |  | 18215135

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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