# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# EPHA2 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (29)
- Disease (2)

Name: Ephrin type-A receptor 2 (EPHA2)
Official Symbol: EPHA2 provided by HGNC
Function:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 1969 | P29317 | DIP-96N | P29317 | MINT-3972729 | 108288 | P29317 |  | hsa:1969 | 176946
Mouse | 13836 | Q03145 | DIP-829N | Q03145 | MINT-3388286 | 199469 | Q03145 |  | mmu:13836 |
Rat | 366492 | D3ZBN3 |  |  |  | 265962 |  |  | rno:366492 |

PPI pairs:

TRPP1

Biological Process:

- GO:0032863 : activation of Rac GTPase activity
- GO:0001525 : angiogenesis
- GO:0006915 : apoptotic process
- GO:0048320 : axial mesoderm formation
- GO:0046849 : bone remodeling
- GO:0060444 : branching involved in mammary gland duct morphogenesis
- GO:0007155 : cell adhesion
- GO:0060326 : cell chemotaxis
- GO:0048013 : ephrin receptor signaling pathway
- GO:0030216 : keratinocyte differentiation
- GO:0070309 : lens fiber cell morphogenesis
- GO:0033598 : mammary gland epithelial cell proliferation
- GO:0051898 : negative regulation of protein kinase B signaling cascade
- GO:0021915 : neural tube development
- GO:0030182 : neuron differentiation
- GO:0060035 : notochord cell development
- GO:0014028 : notochord formation
- GO:0001649 : osteoblast differentiation
- GO:0030316 : osteoclast differentiation
- GO:0090004 : positive regulation of establishment of protein localization to plasma membrane
- GO:0043491 : protein kinase B signaling cascade
- GO:0045765 : regulation of angiogenesis
- GO:0043535 : regulation of blood vessel endothelial cell migration
- GO:0033628 : regulation of cell adhesion mediated by integrin
- GO:0070372 : regulation of ERK1 and ERK2 cascade
- GO:0010591 : regulation of lamellipodium assembly
- GO:0070848 : response to growth factor stimulus
- GO:0001501 : skeletal system development
- GO:0001570 : vasculogenesis

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:176946 : Cataract, posterior polar, 1 (OMIM:116600 )
- OMIM:176946 : Cataract, age-related cortical, 2 (OMIM:613020 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPP1 |  | EPHA2 | Affinity purification-mass spectrometry | Mouse | Not specified | Mouse | Vascular smooth muscle | MOVAS lysates |  | 19879844

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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