# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# 5-HT1B / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (19)
- Disease (0)

Name: 5-hydroxytryptamine receptor 1B (5-HT1B)
Official Symbol: HTR1B provided by HGNC
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 3351 | P28222 | DIP-50302N | P28222 |  | 109583 | P28222 |  | hsa:3351 | 182131
Mouse | 15551 | P28334 |  |  |  | 231585 | P28334 |  | mmu:15551 |
Rat | 25075 | P28564 |  |  |  | 247149 | P28564 |  | rno:25075 |

PPI pairs:

TRPM8

Biological Process:

- GO:0007198 : adenylate cyclase-inhibiting serotonin receptor signaling pathway
- GO:0046849 : bone remodeling
- GO:0071312 : cellular response to alkaloid
- GO:0035690 : cellular response to drug
- GO:0071502 : cellular response to temperature stimulus
- GO:0042756 : drinking behavior
- GO:0002031 : G-protein coupled receptor internalization
- GO:0030818 : negative regulation of cAMP biosynthetic process
- GO:0014063 : negative regulation of serotonin secretion
- GO:0032229 : negative regulation of synaptic transmission, GABAergic
- GO:0051967 : negative regulation of synaptic transmission, glutamatergic
- GO:0007205 : protein kinase C-activating G-protein coupled receptor signaling pathway
- GO:0050795 : regulation of behavior
- GO:0014059 : regulation of dopamine secretion
- GO:0042220 : response to cocaine
- GO:0045471 : response to ethanol
- GO:0051385 : response to mineralocorticoid
- GO:0007268 : synaptic transmission
- GO:0042310 : vasoconstriction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPM8 |  | 5-HT1B | Inference |  |  |  |  |  | Prediction | 24269608

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPM8 |  | 5-HT1B | Co-immunofluorescence staining | Rat dorsal root ganglion neuron |  |  |  |  |  | 24269608
TRPM8 |  | 5-HT1B | Co-immunoprecipitation |  | HEK293 | Not specified | Full-length | Not specified | Full-length | 24269608

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Functional consequence
TRP channel |  | Interactor | Method | Post-translational modification | Subcellular trafficking | Activity | Reference
--- | --- | --- | --- | --- | --- | --- | ---
TRPM8 |  | 5-HT1B | Calcium measurement |  |  | Activation | 24269608

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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