# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# TRF1 / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (15)
- Disease (0)

Name: Telomeric repeat-binding factor 1 (TRF1)
Official Symbol: TERF1 provided by HGNC
Function:
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 7013 | P54274 | DIP-29412N | P54274 | MINT-221323 | 112872 | P54274 |  | hsa:7013 | 600951
Mouse | 21749 | P70371 | DIP-44231N |  | MINT-3379583 | 204116 | P70371 |  | mmu:21749 |
Rat | 297758 | Q5EB98 |  |  | UNK-5438152 | 255652 | Q5EB98 |  | rno:297758 |

PPI pairs:

TRPC5

Biological Process:

- GO:0001309 : age-dependent telomere shortening
- GO:0051301 : cell division
- GO:0000086 : G2/M transition of mitotic cell cycle
- GO:0006917 : induction of apoptosis
- GO:0007067 : mitosis
- GO:0007094 : mitotic cell cycle spindle assembly checkpoint
- GO:0032214 : negative regulation of telomere maintenance via semi-conservative replication
- GO:0032211 : negative regulation of telomere maintenance via telomerase
- GO:0031116 : positive regulation of microtubule polymerization
- GO:0045840 : positive regulation of mitosis
- GO:0045931 : positive regulation of mitotic cell cycle
- GO:0051260 : protein homooligomerization
- GO:0042493 : response to drug
- GO:0007004 : telomere maintenance via telomerase
- GO:0010834 : telomere maintenance via telomere shortening

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease: No information in OMIM
Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPC5 |  | TRF1 | Affinity purification-mass spectrometry | Not used as a bait |  | Human | HEK293T | Cell lystaes |  | 20811636

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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