# TRIP Database

Mammalian TRansient receptor potential channel-Interacting Protein

TRP channels

- TRPC
  - TRPC1
  - TRPC2
  - TRPC3
  - TRPC4
  - TRPC5
  - TRPC6
  - TRPC7
- TRPV
  - TRPV1
  - TRPV2
  - TRPV3
  - TRPV4
  - TRPV5
  - TRPV6
- TRPM
  - TRPM1
  - TRPM2
  - TRPM3
  - TRPM4
  - TRPM5
  - TRPM6
  - TRPM7
  - TRPM8
- TRPML
  - TRPML1
  - TRPML2
  - TRPML3
- TRPP
  - TRPP1
  - TRPP2
  - TRPP3
- TRPA
  - TRPA1

» Citation

# AT1aR / TRP channels

- Basic Information
- External Database
- PPI pairs (1)
- Biological Process (20)
- Disease (2)

Name: Type-1 angiotensin II receptor (AT1aR)
Official Symbol: AGTR1 provided by HGNC
Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Source: Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 40: D71-D75 (2012).

Species | External DB
Name | Description
--- | ---
Entrez Gene | A database that contains genome-centered information
UniprotKB | The central hub for collection of functional information on proteins
DIP | A database that documents experimentally determined PPIs
IntAct | An open source database and software suite for modeling, storing and analyzing molecular interaction data
MINT | A database that collects experimentally verified PPIs in a binary or complex representation
BioGRID | A database of known and predicted PPIs
STRING | An online interaction repository with data
IUPHAR-DB | Integrated pharmacological and pathophysiological information on GPCR and voltage-gated & ligand-gated ion channels
KEGG | A database resource consisting of 16 main databases, categorized into systems information, genomic information, and chemical information
OMIM | A database of human genes and genetic disorders
Entrez Gene | UniprotKB | DIP | IntAct | MINT | BioGRID | STRING | IUPHAR-DB | KEGG | OMIM
Human | 185 | P30556 | DIP-40937N |  | MINT-107041 | 106691 | P30556 |  | hsa:185 | 106165
Mouse | 11607 | P29754 | DIP-33498N | P29754 | MINT-1339574 | 198029 | P29754 |  | mmu:11607 |
Rat | 24180 | P25095 | DIP-33354N | P25095 | MINT-1503145 | 246370 | P25095 |  | rno:24180 |

PPI pairs:

TRPV4

Biological Process:

- GO:0019722 : calcium-mediated signaling
- GO:0060326 : cell chemotaxis
- GO:0051482 : elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
- GO:0001822 : kidney development
- GO:0034374 : low-density lipoprotein particle remodeling
- GO:0032270 : positive regulation of cellular protein metabolic process
- GO:0010873 : positive regulation of cholesterol esterification
- GO:0050729 : positive regulation of inflammatory response
- GO:0010744 : positive regulation of macrophage derived foam cell differentiation
- GO:0033864 : positive regulation of NAD(P)H oxidase activity
- GO:0032430 : positive regulation of phospholipase A2 activity
- GO:2000379 : positive regulation of reactive oxygen species metabolic process
- GO:0002034 : regulation of blood vessel size by renin-angiotensin
- GO:0001558 : regulation of cell growth
- GO:0042127 : regulation of cell proliferation
- GO:0035813 : regulation of renal sodium excretion
- GO:0019229 : regulation of vasoconstriction
- GO:0042312 : regulation of vasodilation
- GO:0002018 : renin-angiotensin regulation of aldosterone production
- GO:0007266 : Rho protein signal transduction

Source: The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet.. May 2000;25(1):25-9.
World Wide Web URL: http://www.geneontology.org/
Disease:

- OMIM:106165 : Hypertension, essential (OMIM:145500 )
- OMIM:106165 : Renal tubular dysgenesis (OMIM:267430 )

Source: Online Mendelian Inheritance in Man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), May, 2012.
World Wide Web URL: http://omim.org/

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Screening
| Experimental screening | Non-experimental screening | Reference
--- | --- | --- | ---
TRP channel construct | Interactor source
TRP channel |  | Interactor | Method | Species | Region | Species | Organ/tissue | Sample type
TRPV4 |  | AT1aR | Inference |  |  |  |  |  | Prediction | 20650893

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)

Screening Validation: In vitro validation Validation: In vivo validation Characterization Functional consequence | top

Validation: In vivo validation
| Assay with endogenous proteins | Assay with overexpressed proteins | Reference
--- | --- | --- | ---
Cell or tissue | Cell or tissue | TRP channel construct | Interactor construct
TRP channel |  | Interactor | Method | Species | Region | Species | Region
TRPV4 |  | AT1aR | Co-immunofluorescence staining |  | Rat vascular smooth muscle cell | Human | Full-length | Human | Full-length | 20650893
TRPV4 |  | AT1aR | Co-immunoprecipitation |  | Rat vascular smooth muscle cell | Not used |  | Human | Full-length | 20650893
TRPV4 |  | AT1aR | Co-immunoprecipitation |  | HEK293 | Human | Full-length | Human | Full-length | 20650893

(: click the arrow icon to show interactions only between the corresponding TRP channel and the interactor)
Name Email Title* Comment* TRP
/ Interactor
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